Log in

Relevant bibliographies by topics / Discovery tools / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Discovery tools.

Dissertations / Theses on the topic 'Discovery tools'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Discovery tools.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Howard, Craig M. "Tools and techniques for knowledge discovery." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368357.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Martins, Tânia Cristina Soares. "Exosomes as tools for biomarker discovery." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/21996.

Full text

Abstract:

Mestrado em Biomedicina Molecular<br>Os exossomas são pequenas vesículas extracelulares envolvidas em vários processos fisiológicos e patológicos. O potencial dos exosomas como fontes de biomarcadores para o diagnóstico, prognóstico e mesmo para a terapêutica tem intensificado a investigação nesta área, apoiando o potencial dos exosomas na descoberta de biomarcadores. A centrifugação diferencial é o método mais usado, mas é demorado, requer grandes volumes de amostra e as altas velocidades de centrifugação podem comprometer a integridade dos exossomas. Apesar das várias opções disponíve

APA, Harvard, Vancouver, ISO, and other styles

3

Corbeil, Christopher. "New virtual screening tools for molecular discovery." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40786.

Full text

Abstract:

In the field of molecular discovery, virtually screening large libraries of compounds proved to be often more cost-efficient than the traditional experimental approaches. In fact, it has now become common practice thanks to the virtual screening tools available to chemists in the pharmaceutical industry, specifically docking. Most docking programs do not account for the dynamics associated with protein-ligand binding whether it is protein flexibility or the inclusion of displaceable water molecules. FITTED1.0 was developed to include these specific two features and has been validated on a test

APA, Harvard, Vancouver, ISO, and other styles

4

Cereto, Massagué Adrià. "Development of tools for in silico drug discovery." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/454678.

Full text

Abstract:

El cribratge virtual és un mètode quimioinformàtic que consisteix en cribrar molècules bioactives de grans bases de dades de molècules petites. Això permet als investigadors d’estalviar-se el cost de provar experimentalment cents o milers de compostos candidats, reduïnt-ne el nombre fins a quantitats manejables. Per a la validació dels mètodes de cribratge virtual calen biblioteques de molècules cimbell. El programari DecoyFinder fou desenvolupat com a aplicació gràfica de fàcil ús per a la construcció de biblioteques de molècules cimbell, i fou posteriorment ampliat amb les troballes de recer

APA, Harvard, Vancouver, ISO, and other styles

5

Jones, Neil Christopher. "Computational tools for high-throughput discovery in biology." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3267820.

Full text

Abstract:

Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed August 7, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 115-127).

APA, Harvard, Vancouver, ISO, and other styles

6

Islam, R. S. "Novel engineering tools to aid drug discovery processes." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444794/.

Full text

Abstract:

A major bottleneck in drug discovery is the production of soluble human recombinant protein for functional, biochemical and structural analyses. The level of recombinant protein expression is controlled by a complex relationship between both biological and engineering variables. Due to the inter-play between these variables and standard experimental methods, the identification of the key variables which lead to improved protein expression can sometimes be missed. This thesis presents a framework which underpins the generation of large quantities of soluble recombinant protein in E. coli in a r

APA, Harvard, Vancouver, ISO, and other styles

7

DePasquale, Erica. "Development of Computational Tools for Single-Cell Discovery." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1614021318421845.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Jenkins, Michael Joseph. "Decisional tools for cost-effective bioprocess design for cell therapies and patient-specific drug discovery tools." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046409/.

Full text

Abstract:

A specific challenge to the translation of cell therapies and stem-cell derived products is the ability to develop and manufacture such products in a cost-effective, scalable and robust manner. To this end, this thesis investigates the creation and application of a set of computational tools designed to aid bioprocess design decisions for cell therapy and stem-cell derived research products. The decision-support tools comprise advanced bioprocess economics models with databases tailored to cellular products. These are linked to Monte Carlo simulation for uncertainty analysis and techniques to

APA, Harvard, Vancouver, ISO, and other styles

9

Hesping, Eva M. "New inhibitors and tools to advance HDAC drug discovery for malaria." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/403646.

Full text

Abstract:

Malaria is a leading cause of morbidity and mortality, causing more than 400,000 deaths per year. Malaria is caused by parasites of the Plasmodium genus with most deaths due to P. falciparum infection. The control of malaria is complicated by the lack of a widely effective vaccine, the spread of mosquito resistance to insecticides and Plasmodium parasite resistance to available drugs, including the gold standard artemisinin-combination therapies. Thus, there is an urgent requirement for the development of new antimalarials, in particular those with different modes of action to existing drugs t

APA, Harvard, Vancouver, ISO, and other styles

10

Carrascosa, Baena María Carmen 1972. "Next generation of informatics tools for big data analytics in drug discovery." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/586011.

Full text

Abstract:

El paradigma clàssic on un medicament interacciona amb un únic target biològic vinculat a una malaltia es posa en dubte. Actualment es reconeix que un medicament interacciona amb múltiples targets biològics i que aquests targets estan involucrats en multitud de pathways i que s’expressen en una varietat d’òrgans. Amb el creixent reconeixement d’aquesta complexitat, la estratègia reduccionista del procés de descoberta de nous medicaments ha evolucionat cap a estratègies sistèmiques multinivell. Gràcies als avenços tecnològics, hi ha hagut un gran increment de les dades generades en les diverse

APA, Harvard, Vancouver, ISO, and other styles

11

Matela, Braquehais Rudy. "Tools for discovery, refinement and generalization of functional properties by enumerative testing." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19178/.

Full text

Abstract:

This thesis presents techniques for discovery, refinement and generalization of properties about functional programs. These techniques work by reasoning from test results: their results are surprisingly accurate in practice, despite an inherent uncertainty in principle. These techniques are validated by corresponding implementations in Haskell and for Haskell programs: Speculate, FitSpec and Extrapolate. Speculate discovers properties given a collection of black-box function signatures. Properties discovered by Speculate include inequalities and conditional equations. These properties can cont

APA, Harvard, Vancouver, ISO, and other styles

12

Hodges, Emily Carol. "High resolution genomic tools for the discovery of protein function in mammalian cells /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-775-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Hill, Nathan Stuart. "Development of new knowledge discovery tools to explore biomedical datasets in breast cancer." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/54473/.

Full text

Abstract:

The explorative power of high throughput technologies in cancer research has become well established in recent years, exemplified by diverse gene microarray studies. However, development of the necessary biomedical data analysis tools has historically been confined to a commercial environment, while comprehensive, user-friendly analysis approaches are still needed. Availability of freely-available software, notably the 'R' project statistical programming language, allowed development of a user-friendly multivariate statistics application - Informatics Tenovus (I-10) - in this project. I-10 pro

APA, Harvard, Vancouver, ISO, and other styles

14

Mezzanotte, Laura <1982&gt. "Bioanalytical applications of multicolour bioluminescence imaging: new tools for drug discovery and development." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3536/1/Mezzanotte_Laura_TESI.pdf.

Full text

Abstract:

The subject of this thesis is multicolour bioluminescence analysis and how it can provide new tools for drug discovery and development.The mechanism of color tuning in bioluminescent reactions is not fully understood yet but it is object of intense research and several hypothesis have been generated. In the past decade key residues of the active site of the enzyme or in the surface surrounding the active site have been identified as responsible of different color emission. Anyway since bioluminescence reaction is strictly dependent from the interaction between the enzyme and its substrate D-lu

APA, Harvard, Vancouver, ISO, and other styles

15

Mezzanotte, Laura <1982&gt. "Bioanalytical applications of multicolour bioluminescence imaging: new tools for drug discovery and development." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3536/.

Full text

Abstract:

The subject of this thesis is multicolour bioluminescence analysis and how it can provide new tools for drug discovery and development.The mechanism of color tuning in bioluminescent reactions is not fully understood yet but it is object of intense research and several hypothesis have been generated. In the past decade key residues of the active site of the enzyme or in the surface surrounding the active site have been identified as responsible of different color emission. Anyway since bioluminescence reaction is strictly dependent from the interaction between the enzyme and its substrate D-lu

APA, Harvard, Vancouver, ISO, and other styles

16

Mathew, Mark. "High throughput imaging for anthelmintic discovery and Caenorhabditis elegans genetic tools for target elucidation." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/56407.

Full text

Abstract:

Nearly three billion humans worldwide have helminth infections, which accounts for a global disease burden of 5.2 million disability-adjusted life years. Parasitic nematodes also have a great affect on agriculture, annually destroying 12.3% of global food crops and accounting for an annual loss of approximately $10 billion (USD) worldwide in the sheep and cattle industry. There is widespread resistance to all classes of anthelmintic drugs. The last drug to enter human clinical trials was 35 years ago. There is a great need for new anthelmintics and this concern has been strongly voiced by the

APA, Harvard, Vancouver, ISO, and other styles

17

Santiago, Daniel Navarrete. "Use and Development of Computational Tools in Drug Discovery: From Small Molecules to Cyclic Peptides." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4398.

Full text

Abstract:

The scope of this work focuses on computationally modeling compounds with protein structures. While the impetus of drug discovery is the innovation of new therapeutic molecules, it also involves distinguishing molecules that would not be an effective drug. This can be achieved by inventing new tools or by refining old tools. Virtual screening (VS, also called docking), the computational modeling of a molecule in a receptor structure, is a staple in predicting a molecule's affinity for an intended target. In our Virtual Target Screening system (also called inverse-docking), VS is used to fin

APA, Harvard, Vancouver, ISO, and other styles

18

Patel, Hitesh [Verfasser], and Irmgard [Akademischer Betreuer] Merfort. "Use and development of chem-bioinformatics tools and methods for drug discovery and target identification." Freiburg : Universität, 2015. http://d-nb.info/1115495917/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Reed, Keith Gregory. "The development and implementation of high-throughput tools for discovery and characterization of proton exchange membranes." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31719.

Full text

Abstract:

Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Meredith, Carson; Committee Member: Bucknall, David; Committee Member: Fuller, Tom; Committee Member: Griffin, Anselm; Committee Member: Koros, William. Part of the SMARTech Electronic Thesis and Dissertation Collection.

APA, Harvard, Vancouver, ISO, and other styles

20

Alanjary, Mohammad [Verfasser], and Nadine [Akademischer Betreuer] Ziemert. "Developing genome mining tools for the discovery of bioactive secondary metabolites / Mohammad Alanjary ; Betreuer: Nadine Ziemert." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1170672264/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Langron, E. "Drug-discovery tools for cystic fibrosis : optical probes to quantify gating and trafficking of ΔF508-CFTR". Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1538676/.

Full text

Abstract:

Cystic fibrosis (CF) is a debilitating disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for the CFTR anion channel. ΔF508, the most common CF-associated mutation, causes both a gating and a trafficking defect in the CFTR protein. This thesis describes the optimisation and use of two fluorescence assays, capable of measuring the two defects caused by the ΔF508 mutation. Yellow fluorescent protein (YFP)-CFTR, in which halide sensitive YFP is tagged to the Nterminal of the CFTR coding sequence, is a functional assay, used to test for

APA, Harvard, Vancouver, ISO, and other styles

22

COLOMBO, ELEONORA. "RATIONAL DESIGN, SYNTHESIS AND NANOTECHNOLOGIES AS TOOLS IN EARLY DRUG DISCOVERY: CANCER AND NEURODEGENERATION AS TARGETS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/818993.

Full text

Abstract:

Rational design, synthesis and nanotechnologies as tools in early drug discovery: cancer and neurodegeneration as targets The rubric “multifactorial” has been applied to several diseases spanning multiple therapeutic areas, e.g. schizophrenia, autism, depression, epilepsy, diabetes, rheumatoid arthritis, hypertension, cancer, Alzheimer's and Parkinson's disease, multiple sclerosis and probably hundreds of other conditions; such label entails that the disease is influenced by multiple genetic and environmental factors, and that its progression is also influenced by a plethora of elements.1 D

APA, Harvard, Vancouver, ISO, and other styles

23

Cornet, Bartolomé Carles 1991. "Novel tools in drug discovery : optimising the use of zebrafish for assessing drug safety and antitumoral efficacy." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668470.

Full text

Abstract:

High drug attrition rate during clinical and post market phases is one of the major factors contributing to the pharmaceutical industry productivity crisis. This problem is especially worrisome in the cancer field, where it is two to four times higher than in other health sectors. Most of the drugs are discarded due to safety (mainly cardio-, neuro-, and hepato-toxicities) and efficacy issues, which reflect the limitations of current preclinical models in anticipating such drawbacks. In this context, new models are needed in order to tackle these problems and to accomplish with the new demands

APA, Harvard, Vancouver, ISO, and other styles

24

Abshire, James R. (James Robbins). "Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98921.

Full text

Abstract:

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Malaria remains a major burden to global public health. Antimalarial drugs are a mainstay in efforts to control and eventually eradicate this disease. However, increasing drug resistance threatens to reverse recent gains in malaria control, making t

APA, Harvard, Vancouver, ISO, and other styles

25

Caie, Peter David. "Discovery of novel prognostic tools to stratify high risk stage II colorectal cancer patients utilising digital pathology." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19527.

Full text

Abstract:

Colorectal cancer (CRC) patients are stratified by the Tumour, Node and Metastasis (TNM) staging system for clinical decision making. Additional genomic markers have a limited utility in some cases where precise targeted therapy may be available. Thus, classical clinical pathological staging remains the mainstay of the assessment of this disease. Surgical resection is generally considered curative for Stage II patients, however 20-30% of these patients experience disease recurrence and disease specific death. It is imperative to identify these high risk patients in order to assess if further t

APA, Harvard, Vancouver, ISO, and other styles

26

Liu, Xiaolin. "Novel bioinformatics tools for elementary repeat assembly, repeat domain discovery, and TE-based analysis of substitution rates." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1525308930990689.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Torabi, Moghadam Behrooz. "Computational discovery of DNA methylation patterns as biomarkers of ageing, cancer, and mental disorders : Algorithms and Tools." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320720.

Full text

Abstract:

Epigenetics refers to the mitotically heritable modifications in gene expression without a change in the genetic code. A combination of molecular, chemical and environmental factors constituting the epigenome is involved, together with the genome, in setting up the unique functionality of each cell type. DNA methylation is the most studied epigenetic mark in mammals, where a methyl group is added to the cytosine in a cytosine-phosphate-guanine dinucleotides or a CpG site. It has been shown to have a major role in various biological phenomena such as chromosome X inactivation, regulation of gen

APA, Harvard, Vancouver, ISO, and other styles

28

Davis, Nicholas Gregory. "Application of Next-Generation Transcriptomic Tools for Non-Model Organisms: Gene Discovery and Marker DevelopmentWithin Plecoptera (Insecta)." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4265.

Full text

Abstract:

Phylogenetic research on non-model organisms has been hindered by limited marker availability. Next generation sequencing techniques are eliminating that barrier. Using Illumina sequencing technology, Trinity assembly software, custom Perl reciprocal BLAST scripts, and Primer3 primer prediction software, we produced and analyzed 7 Plecopteran transcriptomes, representing 7 of the 16 total families, in an attempt to identify and develop conserved orthologous genetic markers. The transcriptomes were used to reconstruct a gene content phylogeny using a simple distance matrix generated from recipr

APA, Harvard, Vancouver, ISO, and other styles

29

Gee, Sally. "The case of research tools for drug discovery : evolving user-producer inter-dependencies and the exchange of knowledge." Thesis, University of Manchester, 2007. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:80887.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Zoccarato, Anna <1991&gt. "L’uso dei discovery tools nelle biblioteche universitarie: indirizzare gli studenti ad un nuovo concetto di ricerca e “scoperta”." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/20063.

Full text

Abstract:

A partire dall’origine e dagli sviluppi odierni dell’università e della biblioteca universitaria, l’elaborato si concentra sulla recente introduzione dei Web scale discovery services per la ricerca bibliografica in ambito accademico, considerati in particolare dal punto di vista dell’interfaccia utente. Vengono perciò esposte le caratteristiche generali di tali strumenti, le attuali considerazioni in merito e le possibili implementazioni future. Inoltre, sono presentati alcuni esempi di discovery tool, sia proprietari che open source, al fine di delineare pro e contro dei nuovi strumenti di “s

APA, Harvard, Vancouver, ISO, and other styles

31

Kamal, Ahmed [Verfasser], and Rolf W. [Akademischer Betreuer] Hartmann. "From Small Organic Molecules to Peptides As Tools For Anti-infectives Drug Discovery / Ahmed Kamal ; Betreuer: Rolf W. Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1152095374/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Kamal, Ahmed Verfasser], and Rolf W. [Akademischer Betreuer] [Hartmann. "From Small Organic Molecules to Peptides As Tools For Anti-infectives Drug Discovery / Ahmed Kamal ; Betreuer: Rolf W. Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1152095374/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Hsing, Michael. "Developing bioinformatics tools and analyses on protein indels and protein-protein interactions : novel applications for drug discovery in Staphylococcus aureus." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/18714.

Full text

Abstract:

Infectious diseases caused by bacterial pathogens continue to be major public health concerns affecting millions of human lives annually, as conventional treatment via antibiotics has lost its effectiveness due to growing problems of drug resistance. Recent advancements in systems biology, high-throughout sequencing, protein interaction study and computer-aided drug development can offer possible solutions to antibiotic resistance through discovery of novel antimicrobials. The thesis describes several bioinformatics approaches that focus on protein interaction network (PIN) studies, analyses

APA, Harvard, Vancouver, ISO, and other styles

34

González, Obando Daniel Felipe. "From digital to computational pathology for biomarker discovery." Electronic Thesis or Diss., Université Paris Cité, 2019. http://www.theses.fr/2019UNIP5185.

Full text

Abstract:

L'histopathologie a pour objectif d'analyser des images de tissus biologiques pour évaluer l’état pathologique d'un organe et établir un diagnostic. L'apparition des scanners de lames a haute résolution a ouvert la voie a des nouvelles possibilités d'acquisition de très grandes images (whole slide imaging), de multiplexage de marquages, d'extraction exhaustive d'informations visuelles et d'annotations multiples a large échelle. Cette thèse propose un ensemble de méthodes algorithmiques visant a faciliter et optimiser ces différents aspects. Dans un premier temps, nous proposons une méthode de

APA, Harvard, Vancouver, ISO, and other styles

35

Khashan, Raed Saeed Tropsha Alexander. "Development and application of ligand-based and structure-based computational drug discovery tools based on frequent subgraph mining of chemical structures." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1243.

Full text

Abstract:

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Pharmacy (Division of Medicinal Chemistry and Natural Products)." Discipline: Medicinal Chemistry and Natural Products; Department/School: Pharmacy.

APA, Harvard, Vancouver, ISO, and other styles

36

Yglesias, Tatiana. "Application of process analysis and optimization tools in hit-to-lead and lead optimization phases of drug discovery at EPP, NIBR." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59882.

Full text

Abstract:

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; and, (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; in conjunction with the Leaders for Global Operations Program at MIT, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 82-84).<br>Given that research is based on innovation, it has been believed that its activities can only be optimized with equipment upgrade, increment in personnel scientific knowledge, development of new analytical software and/or changing the areas of study. After reali

APA, Harvard, Vancouver, ISO, and other styles

37

Goumatianos, Nikitas. "Improving government's retirement plan investments by using mining tools for discovery of price patterns and combining methods of fundamental and technical analysis." Thesis, Monterey, Calif. : Naval Postgraduate School, 2008. http://handle.dtic.mil/100.2/ADA483662.

Full text

Abstract:

Thesis (M.B.A.)--Naval Postgraduate School, June 2008.<br>Thesis Advisor(s): Airola, James. "June 2008." Description based on title screen as viewed on August 22, 2008. Includes bibliographical references (p. 101). Also available in print.

APA, Harvard, Vancouver, ISO, and other styles

38

Murray, Kathleen R. "Students' Criteria for Course Selection: Towards a Metadata Standard for Distributed Higher Education." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2619/.

Full text

Abstract:

By 2007, one half of higher education students are expected to enroll in distributed learning courses. Higher education institutions need to attract students searching the Internet for courses and need to provide students with enough information to select courses. Internet resource discovery tools are readily available, however, users have difficulty selecting relevant resources. In part this is due to the lack of a standard for representation of Internet resources. An emerging solution is metadata. In the educational domain, the IEEE Learning Technology Standards Committee (LTSC) has specifie

APA, Harvard, Vancouver, ISO, and other styles

39

Goldflam, Michael. "Combined use of NMR and computational tools for fragment based drug discovery targeting protein-protein interactions VEGF protein surface recognition as a case study." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/123711.

Full text

Abstract:

The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or biochemical tools.The use of biologics to target protein-protein interfaces is relatively advanced; suffer although from some intrinsic drawbacks as the danger of immunogenicity, the inability to cross biological barriers efficiently and high production costs. Small molecule inhibitors do not necessarily share these drawbacks. Unfortunately the druggability of protein-protein int

APA, Harvard, Vancouver, ISO, and other styles

40

Mahout, Maxime. "Logic programming tools for metabolic fluxes analysis and biological applications." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASG086.

Full text

Abstract:

En biologie des systèmes, l'analyse des voies métaboliques est une méthode essentielle pour étudier le métabolisme et améliorer la compréhension du fonctionnement des systèmes vivants. Deux concepts clés sont l'analyse des modes élémentaires de flux (EFMs), qui permet de décrire les réseaux métaboliques en termes de voies minimales, et les Minimal Cut Sets (MCSs), représentant les coupures minimales de flux du réseau en termes de réactions. Dans le cadre de cette thèse, nous avons développé une méthode de programmation logique pour le calcul des modes élémentaires de flux: aspefm. L'outil est

APA, Harvard, Vancouver, ISO, and other styles

41

Lindkvist, Christoffer, and Stjernberg Niclas. "Customer and product validation for physical product development in a startup context : A study on Lean Startup methods and Design For Six Sigma tools." Thesis, Uppsala universitet, Industriell teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275359.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Guidotti, Laura <1987&gt. "Design and synthesis of small molecules as tools for drug discovery and chemical biology: identification of new LDH-A inhibitors and development of fluorescent probes to investigate neurogenesis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8438/1/Laura%20Guidotti%20Tesi.pdf.

Full text

Abstract:

The present work includes distinct research projects having as common platform the design and synthesis of biologically active small molecules, useful as tools both for drug discovery and chemical biology studies. The main project (Part I) focused on the identification of LDH-A inhibitors as hit candidates in the discovery of new anticancer agents. My work aimed to explore the chemical space around galloflavin (GF) by synthesizing a small library of analogs to perform structure-activity relationships (SAR) studies. GF, LDH-A inhibitor previously identified and synthesized by our group, wa

APA, Harvard, Vancouver, ISO, and other styles

43

Altindis, Emrah <1982&gt. "MetaVaccinology: a new vaccine discovery tool." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3908/2/Emrah_Altindis_MetaVaccinology_Bologna_University_PhD_thesis.pdf.

Full text

Abstract:

In the last decade, the reverse vaccinology approach shifted the paradigm of vaccine discovery from conventional culture-based methods to high-throughput genome-based approaches for the development of recombinant protein-based vaccines against pathogenic bacteria. Besides reaching its main goal of identifying new vaccine candidates, this new procedure produced also a huge amount of molecular knowledge related to them. In the present work, we explored this knowledge in a species-independent way and we performed a systematic in silico molecular analysis of more than 100 protective antigens, loo

APA, Harvard, Vancouver, ISO, and other styles

44

Altindis, Emrah <1982&gt. "MetaVaccinology: a new vaccine discovery tool." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3908/.

Full text

Abstract:

In the last decade, the reverse vaccinology approach shifted the paradigm of vaccine discovery from conventional culture-based methods to high-throughput genome-based approaches for the development of recombinant protein-based vaccines against pathogenic bacteria. Besides reaching its main goal of identifying new vaccine candidates, this new procedure produced also a huge amount of molecular knowledge related to them. In the present work, we explored this knowledge in a species-independent way and we performed a systematic in silico molecular analysis of more than 100 protective antigens, loo

APA, Harvard, Vancouver, ISO, and other styles

45

Kanjariya, Mitesh Mukesh. "Discovery Tool: A Framework for Accelerating Academic Collaborations." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374029435.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Gu, Wenqing. "Tool Integration: Model-based Tool Adapter Construction and Discovery Conforming to OSLC." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169430.

Full text

Abstract:

Tool Integration is a vital part in the modern IT industry. With the ever increasing complexity in reality, more tools in different domains are needed in research and development process. However, currently no vendor has a complete solution for the whole process, and no mature solution to integrate different tools together, thus tools are still used separately in the industry. Due to this separation, the same information is created more than once for different tools, which is both time wasting and error prone.This thesis is part of the research to deliver a model-based tool integration framewo

APA, Harvard, Vancouver, ISO, and other styles

47

Vendlinski, Terry P. (Terry Paul) 1957. "Affecting U.S. education through assessment : new tools to discover student understanding." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8592.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, Technology, Management, and Policy Program, 2001.<br>Includes bibliographical references (p. 173-183).<br>We may have a serious problem with education in the United States. However, the literature suggests one can arrive at differing conclusions about the efficacy of the American educational system depending on what we measure, how we measure it, when we decide to measure, and why we measure. As will be shown, many testing methods currently in vogue in the United States generate data that can lead policy makers

APA, Harvard, Vancouver, ISO, and other styles

48

Basa, Srinivas, and Naveen Ganji. "Enhanced NMS Tool Architecture for Discovery and Monitoring of Nodes." Thesis, Blekinge Tekniska Högskola, Avdelningen för för interaktion och systemdesign, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5473.

Full text

Abstract:

The thesis work intends to provide an architecture for discovery and monitoring of nodes in a network with improved performance and security. The proposed work addresses limitations identified within the scope of this thesis. The limitations are identified by analyzing some of the better existing monitoring tools in the market with the use of different protocols. The proposed work use different protocols depending on the situation of the problem that exists in a network. Analyze the existing network monitoring tools, by performing metrics and overcoming the limitations. We proposed a new archi

APA, Harvard, Vancouver, ISO, and other styles

49

Hatherley, Rowan. "Structural bioinformatics studies and tool development related to drug discovery." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1020021.

Full text

Abstract:

This thesis is divided into two distinct sections which can be combined under the broad umbrella of structural bioinformatics studies related to drug discovery. The first section involves the establishment of an online South African natural products database. Natural products (NPs) are chemical entities synthesised in nature and are unrivalled in their structural complexity, chemical diversity, and biological specificity, which has long made them crucial to the drug discovery process. South Africa is rich in both plant and marine biodiversity and a great deal of research has gone into isolatin

APA, Harvard, Vancouver, ISO, and other styles

50

Gabridge, Tracy, Nicole Hennig, Rebecca Lubas, and Sarah Wenzel. "When a Librarian's Not There to Ask: Creating an Information Resource Advisory Tool." Association of College & Research Libraries, 2005. http://hdl.handle.net/1721.1/32545.

Full text

Abstract:

It is 2am. A professor wakes up with a new direction for her research; she must immediately learn about bioethics. In a dorm a student is finally ready to begin a paper on Cuba. Where do they turn? The library web site presents them with a bewildering array of resources and no librarian on hand to serve as intermediary. How can librarians facilitate research in their absence? What interfaces can be designed to educate users in their search? What metadata is needed to enable accurate retrieval? What is the librarian’s role in the increasingly indirectly-mediated information-seeking env

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!