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Dissertations / Theses on the topic 'Disease of the cervix'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Hughes, Rhona Grace. "The local response to human papillomavirus infection and neoplastic disease of the uterine cervix." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/18973.

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2

Burgess, Carolyn E. "Sexual Function in Women Following Treatment for Cervical Dysplasia and Microinvasive Cervical Carcinoma." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc331592/.

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One hundred women aged 20 to 50 were asked to compare their sexual experience before diagnosis and following treatment for benign and malignant cervical disease. The subjects were divided into five groups: three groups had definite cervical intraepithelial neoplasia (CIN), (Class II or III). Two groups were treated with cryotherapy, and one with hysterectomy. One group had a provisional diagnosis of CIN I, but received no treatment. Subjects in the last group had microinvasive cervical carcinoma and were also treated with hysterectomy. All subjects had ovarian function; all were sexually activ

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3

Odunsi, Adekunle Omatayo. "Immunogenetic analysis of HLA Class II in premalignant disease of the cervix and correlation with HPV status." Thesis, Open University, 1999. http://oro.open.ac.uk/54556/.

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The human papilloma virus (HPY) infection has a causal association with cervical intraepithelial neoplasia (CIN) and cervical cancer. However, pre-malignant or malignant transformation is not always observed with HPY infection. lILA molecules are important in the regulation of the immune response to foreign antigens. The role of genetic variation at the HLA class II loci (DR and DQ) in CIN was investigated in 176 British Caucasian patients and 420 controls (normal cervical cytology and negative for HPY 16, 18, 31 and 33). HLA DQB 1 *03 typing was performed by a novel polymerase chain reactionr

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4

Addae, Haleema. "The impact of positive margins and crypt involvement in excisional procedures of the cervix on recurrence rates of premalignant diseases of the cervix." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33427.

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BACKGROUND Recurrent disease after cervical excisional procedures has been linked to many factors. We aim to determine if positive margins and crypt involvement increased the rate of recurrence of premalignant disease in patients who had excisional procedures. METHODS In this retrospective review of the colposcopy database, patient records and pathology database, women who had cervical excisional procedures at the Groote Schuur Hospital colposcopy clinic in 2010 were followed up until 2015. Recurrence was based on high grade cytology or histology at follow up. Chi-square tests were used to com

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5

Kay, Patti Sheryl. "Typing of human papillomavirus in Western Cape women with cervical intraepithelial neoplasia." Thesis, Cape Technikon, 2002. http://hdl.handle.net/20.500.11838/1471.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, Cape Town, 2002<br>Infection \\'ith specific high risk human papilloma"iruses (HPV) has been shown to play a causal role in the development of ceJVical intraepithelial neoplasia (CIN) and cenical cancer in women. The development of a prophylactic vaccine to immull.ize women against HPV infection would play a \'ita! role in protecting women against HPV infection and ultimately ceMcal cancer. Despite cancer of the cer\'ix being the second most common cancer in South African women, a literature search reveals that few studies have

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6

Chiu, Man-kin, and 趙文健. "Comparison of the efficacy of sample collection for cervical cytology between the application of Cervex-Brush and Clover Brush in ThinPrepliquid-based cervical cytology." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153449.

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7

Сумцов, Георгій Олексійович, Георгий Алексеевич Сумцов, Heorhii Oleksiiovych Sumtsov та ін. "Конусовидная диатермоэксцизия в лечении заболеваний шейки матки". Thesis, Издательство СумГУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27219.

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Проанализированы результаты лечения 120 случаев заболеваний шейки матки методом конусовидной диатермоэксцизии. В плане подготовки к операции всем больным проведенакольпоскопия, цитологическое исследование мазков из цервикального канала и шейки матки, стандартное бактериоскопическое исследование влагалищных мазков. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/27219

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8

Eaker, Sonja. "Optimization of compliance in epidemiologic research and disease prevention : with special emphasis on PAP-smear screening /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-454-2/.

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9

Brestovac, Brian. "Human papillomavirus and cervical cancer in Western Australia." University of Western Australia. School of Biomedical and Chemical Sciences, 2005. http://theses.library.uwa.edu.au/adt-WU2006.0037.

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10

Drezek, Rebekah Anna. "The biophysical origins of cervical tissue fluorescence and reflectance spectra modeling, measurements, and clinical implications /." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3031044.

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11

Nikitina-Zake, Liene. "Immunogenetic markers in immune-mediated diseases /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-718-5/.

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12

Tsun, Ka-lai Obe, and 秦家麗. "Cervical cytology screening in pregnant women." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B4501100X.

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13

Knecht, Vicky Marie. "PATIENTS WITH GYNECOLOGICAL CANCER: COMPARISON OF LEARNING NEEDS OF PATIENTS AND THEIR SIGNIFICANT OTHERS." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/292091.

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14

Wong, Ting-yin, and 王婷妍. "HPV 16 and HPV 18 detection in cytology sample of follicular cervicitis using LAMP assay." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632761.

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15

Lensink, Ingrid. "Characterisation of the Batten disease gene, CLN3 /." Title page, abstract and contents only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phl573.pdf.

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Thesis (Ph.D.)-- University of Adelaide, Dept. of Cytogenetics and Molecular Genetics, 2000.<br>Copies of author's previously published articles inserted. Errata sheets pasted onto front end papers. Bibliography: leaves 156-182.

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16

Gu, Zhengming. "Studies on molecular mechanisms of transformation by human papillomavirus : the role of E6 and E5 oncogenes." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40133.

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The ability of the HPV-18 E6 gene to impair p53-mediated transcriptional activity induced by DNA damaging agents was investigated. It is demonstrated that E6 can abolish DNA damage induced p53-mediated transcription and that a region from amino acid residue 113 to 117 of HPV-18 E6 protein was necessary for E6 to direct the degradation of p53. The biological importance of the E6/p53 interaction was then directly examined in HPV-16 containing cervical carcinoma derived cells by introducing the monomeric p53 mutant which is resistant to E6 mediated degradation. The two major observations made fro

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17

Lee, Yick-Kwong Chris, and 李亦剛. "A follow-up study of "atypical cells" in gynecologic cytology: the impact of the Bethesda System 2001." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010286.

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18

Calvi, Alessandra. "The cell biology underlying juvenile ceroid lipofuscinoses (Batten Disease)." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444129/.

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The juvenile form of Batten Disease (JNCL) is an autosomal recessive neurodegenerative disease caused by mutations in the CLN3 protein, an integral membrane protein of unknown function. The hallmark of JNCL is the accumulation of storage material in lysosomes consisting predominantly of subunit c of mitochondrial ATP synthase. CLN3 protein is present primarily in endosomes and lysosomes in non- neuronal cells, whereas in neuronal cells it is also reported to be in presynaptic vesicles and along the neurites. The current best evidence is that it traffics through the endoplasmic reticulum and Go

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19

Heneghan, Nicola R. "Chronic obstructive pulmonary disease and cervico-thoracic musculoskeletal dysfunction." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4779/.

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Conservative non-pharmacological evidence-based management options for Chronic Obstructive Pulmonary Disease (COPD) primarily focus on developing physiological capacity. With co-morbidities, including those of the musculoskeletal system, contributing to the overall disease severity, further research was needed. This thesis presents a critical review of musculoskeletal management approaches used in COPD, which concluded there is insufficient evidence for using musculoskeletal interventions in COPD management. With a paucity of literature exploring chest wall flexibility and clinical guidelines

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20

Harris, Karol Kaye. "Psychological and contextual correlates of women's gynecological health screening /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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21

Vale, Diama Bhadra Andrade Peixoto do 1978. "Avaliação do rastreamento do câncer do colo do útero na estratégia de saúde da família no município de Amparo, São Paulo, Brasil." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310559.

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Orientador: Luiz Carlos Zeferino<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T19:33:51Z (GMT). No. of bitstreams: 1 Vale_DiamaBhadraAndradePeixotodo_M.pdf: 6577919 bytes, checksum: 70e533105be682a7083418f3bad0b3a0 (MD5) Previous issue date: 2010<br>Resumo: O rastreamento do câncer do colo do útero no Brasil não tem sido efetivo em reduzir as altas taxas de incidência e mortalidade desta neoplasia, apesar de o Ministério da Saúde ter estabelecido há mais de 20 anos as normas definindo a população-alvo e

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22

Lange, Jenny. "Neuron-glia interactions in infantile neuronal ceroid lipofuscinosis (CLN1 disease)." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/neuronglia-interactions-in-infantile-neuronal-ceroid-lipofuscinosis-cln1-disease(ceed9c8f-f40d-4796-be7b-e799fe88b431).html.

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The neuronal ceroid lipofuscinoses (NCLs) are the most common cause of childhood dementia and are invariably fatal. Early, localised glial activation occurs in all forms of NCL and has been shown to be an accurate predictor of areas in which neuronal loss is most pronounced. Indeed, in a tissue culture model of juvenile NCL, glial cells have been shown to actively contribute to neuronal dysfunction and death. So far the role of glial cells has not been established in other forms of NCL and in order to assess glial function in infantile NCL (INCL, CLN1 disease), a series of different tissue cul

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23

Zeier, Michele D. "The effect of highly active antiretroviral therapy on Human Papilloma Virus Infection and Cervical Dysplasia in women living with HIV." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86158.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Title The Effect of Highly Active Antiretroviral Therapy on Human Papilloma Virus Infection and Cervical Cytological Abnormalities in Women Living With HIV Background Human Papillomavirus (HPV) infection causes cervical cancer. The prevalence of HPV-related dysplastic lesions is significantly higher in patients co-infected with the HI virus and thought to be linked to possible more persistent HPV infection. There is, however, conflicting evidence as to whether treatment of Human Immunodeficiency Virus (HIV) infection with

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24

Lai, Kai-yan, and 黎啟欣. "Estimating the age-specific risk of human papillomavirus infection andthe effectiveness of cytology screening in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45172523.

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25

Holtzhausen, Tresia Louisa. "A mathematical investigation of the effects of sexual orientation and HIV status on HPV transmission and vaccination." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/3946.

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The effect of the inclusion of sexual behaviour, particularly three sexual orientation classes, on the transmission dynamics of HPV and cervical cancer incidence was investigated. A comprehensive literature review of mathematical models of HPV transmission and the natural history of cervical cancer was concluded. A mathematical model using ordinary differential equations was developed, which incorporated the three sexual orientation classes, and a sexual mixing algorithm for modelling the transmission dynamics. Reproduction numbers, determined through a simplified version of the developed mode

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26

Long, Deirdré. "An analysis of dose effectiveness and incidence of late rectal complications of high dose-rate brachytherapy in the radical treatment of cervical cancer." Thesis, Bloemfontein : Central University of Technology, Free State, 2007. http://hdl.handle.net/11462/94.

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27

McDonald, Louise Ann. "A Comparison Of The Detection Of Tumour Cells In Cervical Lymph Nodes Of Patients With Head And Neck Squamous Cell Carcinoma By Testing For Spliced Transcripts Of Cytokeratin 5 Immunohistochemistry Or Light Microscopy; And The Prognostic Effect Compared With That Of Other Factors." Thesis, The University of Sydney, 2002. http://hdl.handle.net/2123/4456.

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28

Arnall, Jennifer K. "Susceptibily of colostrum-deprived lambs and lambs receiving colostrum to the cervid adenovirus that causes hemorrhagic disease in deer." Laramie, Wyo. : University of Wyoming, 2007. http://proquest.umi.com/pqdweb?did=1495962561&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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29

Pearse, Yewande Elizabeth Oluwashubomi. "Exploring the potential for gene therapy in multiple forms of neuronal ceroid lipofuscinosis (Batten disease)." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/exploring-the-potential-for-gene-therapy-in-multiple-forms-of-neuronal-ceroid-lipofuscinosis-batten-disease(745c7347-c316-4d7a-9ef4-c2264e746a7d).html.

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The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited lysosomal storage disorders that cause profound neurodegeneration and predominantly affect children. Currently, there are no effective treatments available for any form of NCL. This thesis focuses on novel applications of gene therapy for CLN1 disease, which is caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1) and CLN3 disease, which results from mutations in CLN3, which encodes a lysosomal transmembrane protein of unknown function. Therapy for transmembrane protein-deficient NCLs is complic

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30

Cotterill, Gavin G. "Disease Ecology and Adaptive Management of Brucellosis in Greater Yellowstone Elk." DigitalCommons@USU, 2020. https://digitalcommons.usu.edu/etd/7709.

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Brucellosis is a bacterial infection that primarily affects livestock and can also be transmitted to humans. In the Greater Yellowstone Ecosystem (GYE), elk (Cervus canadensis) and bison (Bison bison) are habitual carriers of Brucella abortus, which arrived to the region with cattle over a century ago. The disease was eliminated from cattle in the United States through widespread control efforts, but is now periodically transmitted back to cattle on open rangelands where they can come into contact with fetal tissues and fluids from disease-induced abortions that occur among elk during the late

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31

Anjos, Bruno Leite dos. "Doen?a do armazenamento lisossomal causada pela ingest?o espont?nea de Sida carpinifolia em cervos Sambar (Cervus unicolor) cativos no Rio de Janeiro." Universidade Federal Rural do Rio de Janeiro, 2010. https://tede.ufrrj.br/jspui/handle/jspui/2252.

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Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2018-04-11T13:17:41Z No. of bitstreams: 1 2010 - Bruno Leite dos Anjos.pdf: 12893665 bytes, checksum: 99b4dd0f8ecdebb1f227aa0522ac061f (MD5)<br>Made available in DSpace on 2018-04-11T13:17:42Z (GMT). No. of bitstreams: 1 2010 - Bruno Leite dos Anjos.pdf: 12893665 bytes, checksum: 99b4dd0f8ecdebb1f227aa0522ac061f (MD5) Previous issue date: 2010-08-17<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico, CNPq, Brasil.<br>Cases of diseases induced by toxic plants in domestic herbivores are well reported throughout the world and ha

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32

Petcherski, Anton [Verfasser], Mika [Akademischer Betreuer] Ruonala, Susan [Akademischer Betreuer] Cotman, Walter [Gutachter] Volknandt, and Paul [Gutachter] Dierkes. "Identification of disease modulating compounds in juvenile neuronal ceroid lipofuscinosis (JNCL) / Anton Petcherski. Betreuer: Mika Ruonala ; Susan Cotman. Gutachter: Walter Volknandt ; Paul Dierkes." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/1108411401/34.

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33

Smith, Jye Geoffrey. "Bioimpedance mapping of the cervix." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/17782/1/Jye_Smith_Thesis.pdf.

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Bioimpedance spectroscopy has shown potential as a method for characterising biological tissue with the use of a tetrapolar electrode configuration. Brown et al. (2000) demonstrated that the configuration is capable of distinguishing between normal squamous epithelium and Cervical Intra-epithelial Neoplasia (CIN). However little has been done to identify the volumes of tissue that contribute to the measured impedance. Brown et al. employed a probe with a single tetrapolar electrode set thus analysing single points of tissue. The probe was required to be moved in order to "sample" other areas o

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34

Smith, Jye Geoffrey. "Bioimpedance mapping of the cervix." Queensland University of Technology, 2008. http://eprints.qut.edu.au/17782/.

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Bioimpedance spectroscopy has shown potential as a method for characterising biological tissue with the use of a tetrapolar electrode configuration. Brown et al. (2000) demonstrated that the configuration is capable of distinguishing between normal squamous epithelium and Cervical Intra-epithelial Neoplasia (CIN). However little has been done to identify the volumes of tissue that contribute to the measured impedance. Brown et al. employed a probe with a single tetrapolar electrode set thus analysing single points of tissue. The probe was required to be moved in order to "sample" other areas o

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35

Macdonald, Robert Duncan. "The cervix in pregnancy : an ultrasonographic investigation of the cervix and cervical change through pregnancy." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/cdf0c3f4-5f40-4465-bcbc-a2cabdfa6d33.

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36

Karnaki, Panagiota. "Attitudes, practices and knowledge regarding cervical cancer screening among Greek women in the area of Perth." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2000. https://ro.ecu.edu.au/theses/1373.

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The purpose of this thesis is to study the attitudes, practices and knowledge of Greek women in Perth, Western Australia, regarding cervical cancer screening. This is important because no study has yet examined the cervical screening pattern of this group, despite their low participation rate in screening programs. Qualitative semi-structured interviews among 15 Greek women in Perth were used for data collection. Interviews were conducted both in English and Greek. Eight out of the 15 women interviewed did not participate in frequent screening and many had had only one Pap test in their life.

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37

Wendt, Kristy. "Phenotypic characterization of mouse models for the neuronal ceroid lipofuscinoses /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1426114.

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38

Beaudenon, Sylvie. "Clonage moleculaire et caracterisation du genome de quatre papillomavirus humains associes a des lesions benignes ou a des neoplasies des muqueuses." Paris 6, 1988. http://www.theses.fr/1988PA066048.

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39

Somogyi, Aleksandra [Verfasser], Walter [Gutachter] Volknandt, and Paul [Gutachter] Dierkes. "Disruption of the intracellular trafficking of ganglioside GM1 in a genetically accurate model of the neurodegenerative storage disease juvenile neuronal ceroid-lipofuscinosis / Aleksandra Somogyi. Gutachter: Walter Volknandt ; Paul Dierkes." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/1108411495/34.

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40

Whittaker, Judith Alice. "A critical analysis of the grading system at present in use at Groote Schuur hospital cytology laboratory for endocervical glandular atypical changes with recommendations for improved criteria and terminology." Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/26266.

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41

Busby-Earle, R. M. Camille. "Carcinoma of the cervix : molecular genetic analysis." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20359.

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RFLP analysis was used to detect loss of heterozygosity in tumour/blood pairs, from patients with cervical carcinoma, to examine the role of commonly implicated tumour suppressor genes in cervical carcinogenesis. Allele losses were detected less frequently than has been reported in many other common solid tumours. This relatively low level of allele loss was supported by the infrequent genetic alteration identified when comparison was made between tumour/blood DNA fingerprints from cervical carcinoma patients and those with cancers of non-cervical origin. No correlation was found between allel

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42

Weyn, Christine. "Human papillomavirus prevalence and expression in trophoblastic and cervical cells." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210012.

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Human papillomavirus (HPV) is a double-stranded DNA virus, typically infecting mucosal or cutaneous epithelial keratinocytes. Today, more than 118 different HPV types have been formally described. Sexual transmission of mucosal HPVs is very common and generally asymptomatic, but HPV infection can be associated with benign lesions such as condylomata acuminata or, in rare cases, with malignant lesions such as cervical cancer. Two prophylactic vaccines are currently available in Europe, protecting against HPV-16 and HPV-18 (Cervarix&63720;) or against HPV-6, HPV-11, HPV-16 and HPV-18 (Gardasil&6

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43

Liu, Po-Ching. "Molecular genetic investigation of animal models for human neuronal ceroid lipofuscinoses /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841169.

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44

Williams, Lynda Ann. "Students first : a trans-disciplinary team approach to the education of a student with Battens disease : a dissertation submitted in partial fulfilment of the requirements for the degree of Master of Teaching and Learning in the University of Canterbury /." Thesis, University of Canterbury. Educational Studies and Human Development, 2008. http://hdl.handle.net/10092/2647.

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This New Zealand case study explored how ten members in one trans-disciplinary team perceive and meet the educational needs of a student with Batten’s disease in an inclusive school setting and uses qualitative methodology. This report details the results of ten semi-structured interviews that were conducted with the trans-disciplinary team members. There were three themes that emerged from this research. Firstly, all the team members were in agreement that the student’s happiness was of paramount importance and they wanted her to be included with her peers. Secondly, the family’s goals and as

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45

Guerrero, Cynthia. "Cervical cancer risk behaviors in women attending a dysplasia clinic in Chihuahua City." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2008. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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46

Galbraith, Kevin. "Cervical cancer screening in Hong Kong : addressing inequity /." Thesis, Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/b39724104.

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47

Tse, Chi-ying, and 謝志英. "Quantitative analysis of oncostatin M receptor (OSMR) status in normalcervix and different stages of cervical carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44658862.

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48

Sanford, Tiffany Casandra. "Psychosocial factors associated with cervical dysplasia /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3099630.

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49

ALFRED, VICTOR IFEOLUWA. "GENETIC SCREENING TO IDENTIFY INTERACTORS OF ESCRT-II SUBUNIT, VPS25, AND PRELIMINARY CHARACTERISATION OF CANDIDATES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/560382.

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ESCRT (Endosomal Sorting Complex Required for Transport) proteins regulate cell surface receptor degradation by sorting and packaging ubiquitinated cargoes into the intraluminal vesicles of multivesicular bodies (MVBs). A range of human diseases including cancer, and neurodegeneration display altered expression or are caused by mutations of ESCRT subunits. Studies have shown that Drosophila tissues lacking ESCRTs display neoplastic-like features like overproliferation and polarity defects, partly due to aberrant signalling including Notch signalling. To understand ESCRT-regulated processes in

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Tsun, Ka-lai Obe. "Cervical cytology screening in pregnant women /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36586547.

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