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Dissertations / Theses on the topic 'Diseases of the blood system (DBS)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Santos, Fernando dos. "Curso temporal das alterações autonômicas e metabólicas da hipertensão por sobrecarga de frutose: papel do barorreflexo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-02052016-084732/.

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O aumento do consumo de frutose nas últimas décadas está intimamente associado à maior incidência de obesidade e síndrome metabólica e co-morbidades associadas , como , a dislipidemia, a disautonomia e o diabetes. No entanto, a literatura não apresenta caracterização temporal dos eventos que ocorrem até o estabelecimento das doenças. Com base nisso, este trabalho tem como objetivo avaliar as alterações temporais autônomicas e metabólicas em modelo de síndrome metabólica induzida por sobrecarga de frutose, com ênfase no papel do barorreflexo, aqui testado pelo uso da desnervação sinoaórtica. Ad

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2

Lemogoum, Daniel. "Mécanismes des maladies cardiovasculaires chez le sujet noir africain: le vieillissement artériel précoce serait-il un déterminant ?" Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209075.

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RESUME DES TRAVAUX<p><p>La rigidification des gros troncs artériels (GTA) est physiologiquement liée à l’âge et s’accélère sous l’influence de certains facteurs de risque cardiovasculaire tels que l’hypertension artérielle (HTA), le diabète, le tabagisme, la dyslipidémie, l’obésité, la consommation excessive de sel, la sédentarité et l’hérédité. Le vieillissement artériel prématuré est un déterminant majeur du risque d’événements cardiovasculaires. Il se caractérise par une altération des propriétés élastiques des GTA, consécutive à l’épaississement de l’intima et surtout de la média se tradui

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3

Khou, Cécile. "Etude du neurotropisme des Flavivirus neuropathogènes." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC305/document.

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Les Flavivirus neuropathogènes, tels que le virus de l’encéphalite japonaise (JEV), le virus West Nile (WNV), le virus de la fièvre jaune (YFV) et le virus Zika (ZIKV) causent des maladies neurologiques. Ces maladies sont dues à une infection des cellules du système nerveux central (CNS) par ces virus. Le CNS est un organe privilégié, isolé des agents pathogènes par une barrière entre le sang et le cerveau, appelée barrière hémato-encéphalique (BBB). Les Flavivirus neuropathogènes capables de traverser cette BBB afin d’atteindre leurs cellules cibles, localisées dans le CNS, sont neuroinvasifs

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4

Aronson, Ingrid. "The cytopenias in systemic lupus erythematosus." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/26344.

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5

Turnbull, Fiona. "Effects of different blood pressure-lowering regimens on major cardiovascular events in major patient subgroups." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28142.

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Background Cardiovascular disease is a leading cause of mortality and morbidity worldwide. Blood pressure is the single, most important risk factor for cardiovascular disease; nearly two-thirds of all strokes and approximately half of all ischaemic heart disease events are attributable to non-optimal blood pressure. The evidence from individual randomised trials of blood pressure lowering regimens suggests that that protection from major cardiovascular events can be achieved by lowering blood pressure, even among those with so-called ‘normal’ blood pressures. However, many trials are no

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6

Murchie, Karen J. (Karen Jo) 1973. "Arterial function in hypertension and heart failure." Monash University, Faculty of Medicine, 2000. http://arrow.monash.edu.au/hdl/1959.1/8884.

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7

Khan, Hassan. "Markers of glycaemia and risk of cardiovascular disease." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648585.

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8

Moore, Vivienne M. "Fetal growth and cardiovascular risk factors in an Australian cohort /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phm824.pdf.

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9

Shanbhag, Preeti Pandurang. "Role of Mechanical Versus Humoral Effects of Angiotensin II on Vascular Remodeling." Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/10446.

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In this study, we investigated the role of Ang II in pathological vascular remodeling. We sought to determine whether the humoral or the mechanical effects of Ang II are the dominant factor driving the remodeling process. The following experimental groups were used: control group (untreated mice), mice treated with an angiotensin receptor blocker (Candesartan, 0.5 mg/kg/day,SQ), an ACE inhibitor (Captopril, 6 mg/kg/day), and a calcium-channel blocker (Amlodipine, 7.5 mg/kg/day). All mice (n=6 per experimental group) were from the C57Bl/6 background. The carotid ligation model was implemen

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10

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies." Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb578.pdf.

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"May 2002" Includes bibliographical references (leaves 229-251) Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.

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11

Cole, Sarajane. "The effects of supervisor intervention on hypertensive employees' blood pressure in an industrial hypertension program." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/43391.

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12

Dai, Yuk-ling Eunice, and 戴毓玲. "Effect of coenzyme Q10 supplementation on mitochondrial function and vascular function in patients with cardiovascular disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45152949.

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13

Chan, Hoi Huen. "The vascular modulation effect of Panax ginseng." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1518.

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14

Osburg, Berit. "Drug delivery of oligonucleotides at the blood brain barrier a therapeutic strategy for inflammatory diseases of the central nervous system /." [S.l.] : [s.n.], 2003. http://archiv.ub.uni-marburg.de/diss/z2003/0551/.

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15

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies / Tina Bianco-Miotto." Thesis, Adelaide, S.A, 2002. http://hdl.handle.net/2440/21857.

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"May 2002"<br>Includes bibliographical references (leaves 229-251)<br>xv, 251 leaves : ill. (some col.) ; 30 cm.<br>Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2003

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16

Wang, Siqi. "NONINVASIVE ASSESSMENT AND MODELING OF DIABETIC CARDIOVASCULAR AUTONOMIC NEUROPATHY." UKnowledge, 2012. http://uknowledge.uky.edu/cbme_etds/5.

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Noninvasive assessment of diabetic cardiovascular autonomic neuropathy (AN): Cardiac and vascular dysfunctions resulting from AN are complications of diabetes, often undiagnosed. Our objectives were to: 1) determine sympathetic and parasympathetic components of compromised blood pressure regulation in patients with polyneuropathy, and 2) rank noninvasive indexes for their sensitivity in diagnosing AN. Continuous 12-lead electrocardiography (ECG), blood pressure (BP), respiration, regional blood flow and bio-impedance were recorded from 12 able-bodied subjects (AB), 7 diabetics without (D0), 7

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17

Hurley, Nicole Elizabeth. "Modulating the Functional Contributions of c-Myc to the Human Endothelial Cell Cyclic Strain Response." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19822.

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With each heartbeat, major arteries experience circumferential expansion due to internal pressure changes. This pulsatile force is called cyclic strain and has been implicated in playing a pivotal role in the genetic regulation of vascular physiology and pathology. This dissertation investigates the hypothesis that in human umbilical vein endothelial cells (HUVEC), pathological levels of cyclic strain activate the c-Myc promoter, leading to c-Myc transcription and downstream gene induction. To determine expression and time-dependency of c-Myc in HUVEC, mRNA and protein expression of c-My

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18

Hou, Tianfei. "MECHANISMS AND POTENTIAL THERAPY ON DISRUPTED BLOOD PRESSURE CIRCADIAN RHYTHM IN DIABETES." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/26.

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Arterial blood pressure (BP) undergoes a 24-hour oscillation that peaks in the active day and reaches a nadir at night during sleep in humans. Reduced nocturnal BP fall (also known as non-dipper) is the most common disruption of BP circadian rhythm and is associated with increased risk of untoward cardiovascular events and target organ injury. Up to 75% of diabetic patients are non-dippers. However, the mechanisms underlying diabetes associated non-dipping BP are largely unknown. To address this important question, we generated a novel diabetic db/db-mPer2Luc mouse model (db/db-mPer2Luc) that

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19

Kim, Sungho. "Influence of biomechanical force and mass transfer on the progression of atherosclerosis in human carotid arteries." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41192.

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Atherosclerosis is a vascular degenerative disease leading to progressive thickening in the intima of large and medium sized arteries through the formation of plaque that is very rich with cholesterol. The cholesterol is carried by LDL (low density lipoprotein) particles which pass through the endothelium and accumulate in the intima. The passage of LDL is influenced by wall shear stress which activates physiological responses of the endothelium. However, the causal relationship between the physiological responses and their effect on LDL mass transport is not fully understood. To obtain blood

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20

Lucca, Julie Ann. "ASSOCIATIONS BETWEEN ALCOHOL CONSUMPTION AND FASTING BLOOD GLUCOSE IN YOUNG ADULTS." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1057.

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Current research shows moderate alcohol consumption is associated with decreased risk of diabetes and excessive consumption or binge drinking can cause insulin resistance and diabetes. In 2010, diabetes was the seventh leading cause of death in the United Statesand was responsible for significant health complications: blindness, kidney failure, and limb amputations, and is a large national economic burden. Fasting blood glucose (FBG) is a tool used to help diagnose diabetes. Abnormally high FBG, ≥100 mg/dl, is indicative of diabetes and pre-diabetes. Few studies have observed diabetic prevalen

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21

Acevedo, Lipes Andrea Milena. "Deep Learning System for the Automatic Classification of Normal and Dysplastic Peripheral Blood Cells as a Support Tool for the Diagnosis." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/671387.

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Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of serious diseases. Disadvantages of visual morphological analysis are that it is time consuming, needs expertise to perform an objective review of the smears and is prone to inter-observer variability. Also, most of the morphological descriptions are given in qualitative terms and there is a lack of quantitative measures. The general objective of this thesis is the automatic recognition of no

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22

Zarini, Gustavo G. "The Effect of Vitamin D3 Supplementation on Kidney Function and Cardiovascular Disease Markers among Hispanics and African Americans with Type 2 Diabetes." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3376.

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Serum vitamin D deficiency/insufficiency, Chronic Kidney Disease (CKD) and elevated blood pressure are important health concerns especially among minorities with type 2 diabetes. The effect of vitamin D3 supplementation (cholecalciferol) at 6,000 IU/day (d) vs. 4,000 IU/d on kidney function and cardiovascular disease markers among Hispanics and African Americans with type 2 diabetes and hypovitaminosis D (/ml) was evaluated. Subjects (n=63) were recruited from two clinics in Miami-Dade County, FL. Fasting venous blood and fresh, single-voided first morning urine samples were collected from eac

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23

Möllsten, Anna. "Factors influencing the risk of diabetic nephropathy : analyses of genes, smoking and diet." Doctoral thesis, Umeå universitet, Pediatrik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-911.

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Diabetic long-term complications, despite intensive treatment, cause serious handicaps at relatively young age in diabetic patients. Diabetic nephropathy (DN) develops in up to 30% of patients with type 1 diabetes (T1D). Besides the eventual loss of kidney function, with need for dialysis treatment and transplantation, this complication also increases the risk of early death from cardiovascular disease. In addition to hyperglycaemia, the risk of developing DN is influenced by a number of life-style related factors, such as smoking and diet, but the mechanisms of action of these factors are lar

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24

ELIAS, CAROLINE C. "Obtenção, caracterizações estruturais e atividade enzimática do sítio C-catalítico da enzima conversora de angiotensina I - região ALAsup(959) até SERsup(1066)." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/25320.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-12-17T09:13:12Z No. of bitstreams: 0<br>Made available in DSpace on 2015-12-17T09:13:12Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado em Tecnologia Nuclear)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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25

Allen, Nancy A. "Changing Physical Activity Behavior with Continuous Glucose Monitoring: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsn_diss/2.

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Up to 60% of individuals with type 2 diabetes (T2DM) do not participate in regular physical activity (PA) despite the known benefits. To encourage these individuals to increase PA behavior, this study tested the feasibility and implementation of a nurse-directed counseling intervention using continuous glucose monitoring system (CGMS). The study used a framework derived from self-efficacy theory to 1) compare changes in self-efficacy, BP and activity counts between participants receiving CGMS counseling and standard T2DM counseling, 2) examine relationships between PA self-efficacy and BP and

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26

Viljoen, Janet Erica. "Strength training and cardiovascular risk post-menses, with particular emphasis on the plasma lipoproteins: a controlled trial." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1013578.

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Introduction: Cardiovascular disease affects a greater proportion of females than it does males, and is responsible for an estimated 52 percent of female deaths per annum, globally. Due to the loss of oestrogen associated with the menopause, post-menopausal females are at elevated risk for hypercholesterolaemia which is a primary risk factor for cardiovascular disease. It has not yet been conclusively established whether resistance training can be used to ameliorate hypercholesterolaemia. Aim: This randomized controlled trial investigated what effect 12 weeks of progressive resistance training

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27

Sayyad, Megan R. "The role of Syndecan-1 and extracellular vesicles in breast cancer brain metastasis." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5874.

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Breast cancer metastasizes to the brain in 15-30% of all breast cancer cases, and metastasis is the predominant cause of breast cancer-related deaths. Patients with HER2-enriched and triple-negative breast cancers (TNBCs) are more likely to develop brain metastases. While targeted therapies exist for HER2-enriched breast cancers, there are no effective treatments for TNBCs. Thus, a greater understanding of how these cancers spread to the brain is critical. In order to spread to the brain, disseminated breast cancer cells must overcome 2 major steps—crossing the blood-brain barrier (BBB) and su

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28

Crymble, Tegan. "Cardiovascular disease risk in Black African females and the efficacy of a walking programme on blood pressure in a sub-sample." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1013234.

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The purpose of the study was to investigate the cardiovascular disease (CVD) risk profile of black African females in the Makana region, Eastern Cape, South Africa. Baseline measures from 40 participants, who met the criteria, were compared against the 2003 South African Demographic and Health Survey (SADHS) and the 2013 South African National Health and Nutritional Examination Survey (SANHANES-1). The risk factors measured were anthropometric (stature, body mass and body mass index (BMI)), morphological (waist circumference (WC), fat mass and lean mass), cardiovascular (heart rate and blood p

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29

Rodrigues, Sara. "Avaliação da rigidez arterial e da resistência vascular periférica em pacientes recém-diagnosticados com síndrome metabólica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-24102016-115125/.

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Além das alterações autonômicas, a síndrome metabólica (SMet) causa disfunção vascular relacionada a eventos cardiovasculares e morte. Considerando que a resistência à insulina é associada à hiperativação simpática, testamos a hipótese de que a presença da glicemia de jejum alterada (GLI) é a principal causa das alterações estruturais e funcionais em grandes e pequenos vasos, via aumento do tônus simpático nesses pacientes. Foram avaliados pacientes com SMet recém diagnosticados (ATP-III) e não medicados, divididos em: glicemia de jejum alterada >=100mg/dL (SMet+GLI, n=35; 50±1 anos) e glicemi

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30

Amante, Daniel J. "Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/848.

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Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters. Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients wi

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31

Amante, Daniel J. "Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/848.

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Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters. Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients wi

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32

Bhagavatheeshwaran, Govind. "Magnetic Resonance Imaging of the Rat Retina." Worcester, Mass. : Worcester Polytechnic Institute, 2008. http://www.wpi.edu/Pubs/ETD/Available/etd-041608-144837/.

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Thesis (Ph.D.)--Worcester Polytechnic Institute.<br>Keywords: Mn54-autoradiography, rat retina, manganese enchanced mri, rcs rat, magnetic resonance imaging, retinal degeneration, high-resolution mri, blood volume imaging Includes bibliographical references (leaves 211-226).

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33

Gellar, Lauren A. "The Effect of Glycemic Index and Glycemic Load on Glucose Control, Lipid Profiles and Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/522.

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Background The incidence of type 2 diabetes has increased dramatically, particularly among Latinos. While several studies suggest the beneficial effect of lowering glycemic index and glycemic load in patients with type 2 diabetes, no data exists regarding this issue in the Latino population. The purpose of this study was to determine the effect of lowering glycemic index and glycemic load on diabetes control, lipid profiles and anthropometrics among Latinos with type 2 diabetes. Methods Subjects participated in a 12 month randomized clinical trial. The intervention targeted diabetes knowledge,

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34

Pizzi, Oswaldo Luiz. "Velocidade da onda de pulso em adultos jovens acompanhados por 18 anos: impacto de variáveis pressóricas, antropométricas, metabólicas, inflamatórias e de função endotelial. Estudo do Rio de Janeiro." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4851.

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Dados sobre a avaliação não invasiva da rigidez vascular e suas relações com variáveis de risco cardiovascular são escassos em jovens. Objetiva avaliar a relação entre a velocidade de onda de pulso (VOP) e a pressão arterial (PA), variáveis antropométricas, metabólicas, inflamatórias e de disfunção endotelial em indivíduos adultos jovens. Foram estudados 96 indivíduos (51 homens) do Estudo do Rio de Janeiro, em duas avaliações, A1 e A2, com intervalo de 17,691,58 anos (16 a 21 anos). Em A1 foram avaliados em suas escolas (10-15 anos - média 12,421,47 anos) e em A2 foram novamente avaliados em

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35

Henninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.

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Traumatic brain injury (TBI) is a leading cause of disability worldwide. Annually, 150 to 200/1,000,000 people become disabled as a result of brain trauma. Axonal degeneration is a critical, early event following TBI of all severities but whether axon degeneration is a driver of TBI remains unclear. Molecular pathways underlying the pathology of TBI have not been defined and there is no efficacious treatment for TBI. Despite this significant societal impact, surprisingly little is known about the molecular mechanisms that actively drive axon degeneration in any context and particularly followi

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36

PILLAI, Vinoshene. "Intravital two photon clcium imaging of glioblastoma mouse models." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/109211.

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37

Ji, Hayeun. "In vitro microphysiological system for modeling vascular disease." Thesis, 2018. https://doi.org/10.7916/D8B29C6G.

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In vitro microphysiological system utilizes engineered tissue constructs from human cells to model functional activity of human tissues or organs in both healthy and diseased state, thereby providing a more accurate drug screening than animal models prior to clinical trials. One essential component of an in vitro microphysiological system is a tissue engineered blood vessel (TEBV) that can accurately recapitulate the functional vasculature in vivo. This thesis first explores two most important considerations to a successful TEBV generation, the cell source and the fabrication method. To engine

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38

Moore, Vivienne Marie. "Fetal growth and cardiovascular risk factors in an Australian cohort / Vivienne Moore." Thesis, 1997. http://hdl.handle.net/2440/19017.

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Bibliography: leaves 192-212.<br>xv, 212 leaves ; 30 cm.<br>The present study investigates the relationships between fetal growth, as manifest in size and shape at birth, and later blood pressure and blood lipids, in an Australian cohort. Data on these outcomes for cohort members at age 8 years are available from a previous study. Birth details (body weight, placental weight, head circumference, chest circumference and length) are abstracted from hospital records. In addition, a follow up of cohort members is undertaken to collect new data pertaining to the two cardiovascular risk factors at 2

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39

"Application of copper vapour laser in gastrointestinal tract-experimental studies in animal models." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5887190.

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by Ng Chung Ying Davy.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 91-103).<br>ACKNOWLEDGMENT --- p.1<br>ABSTRACT --- p.2<br>Chapter CHAPTER 1 : --- INTRODUCTION --- p.3<br>Chapter CHAPTER 2 : --- LITERATURE REVIEW --- p.5<br>Chapter 2.1. --- The History of Laser --- p.5<br>Chapter 2.1.1 --- Pre-Maser History (1917 - 1952) --- p.5<br>Chapter 2.1.2. --- The Development of the Maser (1953 - 1959) --- p.6<br>Chapter 2.1.3. --- The Development of the Laser (1960 - 1961) --- p.7<br>Chapter 2.1.4. --- Expanding the Laser Concept

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40

Wu, Shih-Ying. "Neuronavigation-Guided Transcranial Ultrasound: Development towards a Clinical System and Protocol for Blood-Brain Barrier Opening." Thesis, 2016. https://doi.org/10.7916/D8RV0P6F.

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Brain diseases including neurological disorders and tumors remain undertreated due to the challenge in accessing the brain, and blood-brain barrier (BBB) restricting drug delivery, which also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with acoustic agents including microbubbles and nanodroplets remains as the only method to open the BBB noninvasively, locally, and transiently to assist drug delivery. For an ideal medical system to serve a broad patient population, it requires precise and flexible targeting with simulation to personalize treatment,

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Osburg, Berit [Verfasser]. "Drug delivery of oligonucleotides at the blood brain barrier : a therapeutic strategy for inflammatory diseases of the central nervous system / Berit Osburg." 2003. http://d-nb.info/972856692/34.

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42

O'Keefe, Denise Susan. "Molecular analysis of changes in ABO blood group antigen expression in haematological malignancy / Denise S. O'Keefe." 1995. http://hdl.handle.net/2440/18642.

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Errata inserted on back end paper.<br>Bibliography: leaves 226-254.<br>xviii, 261 leaves : ill. ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Describes the development of techniques to genotype and simultaneously assess allele dosage at the ABO locus using PCR and allele-specific restriction enzyme digestion.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1996

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"A simulation system of vascular interventional radiology procedures for training endovascular skills." 2012. http://library.cuhk.edu.hk/record=b5549396.

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近年来，血管类疾病已经成为人类健康的第一杀手。每年有成百上千万人死于血管疾病。血管介入术是一种非常有前景的血管类疾病的治疗手段。血管介入术是一种微创手术，它已经被广泛的用于治疗中风，血管狭窄，血管瘤等疾病。相对于传统的开放式手术，它具有风险低，恢复快，住院时间短等优点。该疗法通常在透视影像的引导下由导管和导线在血管内协同完成手术过程。因为介入术的复杂性和特殊性，作为介入手术医生的必要技能，掌握手术中手眼协同，各种手术器具的使用和复杂细致的手术流程无疑是一个巨大的挑战。因此，迫切地需要一种高效、安全的训练系统。相对于传统的训练方法，基于虚拟现实技术的训练系统是一种非常好的训练手段。<br>为了建立一套高仿真的介入手术训练模拟器，首先，我们要为病人的血管网重建三维模型。我们提出了一种自动的提取中心线的方法，用来从分割好的CTA/MRA体数据中获取病人血管网的中心线。基于改进的平行传递算法，沿着这些中心线，生成了一系列连续的标架。根据这些标架，我们构造了血管的横截面，并在此基础上生成了光滑连续的三维血管模型。<br>其次，作为血管介入术中最基础和最重要的手术器械，我们为导管和导线建立了物理模型。我们提出了一种基于最小势能原理的可变形的模型用于模拟导管和导线对于受力的反应。我们还提出了一个快速并且稳定的多网格算法来保证模拟的真实性和严格的实时交互要求。另外，我们做了几组实验。通过这些实验，

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Πολυχρονόπουλος, Παναγίωτης. "Παράγοντες κινδύνου αγγειακού εγκεφαλικού επεισοδίου". Thesis, 1994. http://nemertes.lis.upatras.gr/jspui/handle/10889/2949.

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"Effect of oxidized LDL and oxidized cholesterol on cardiovascular system." 2005. http://library.cuhk.edu.hk/record=b5892329.

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Ng Chi Ho.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 147-160).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGMENTS --- p.I<br>ABSTRACT --- p.II<br>LIST OF ABBREVIATIONS --- p.VII<br>TABLE OF CONTENTS --- p.IX<br>Chapter CHAPTER 1 --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Introduction of Low-density lipoprotein --- p.1<br>Chapter 1.1.1 --- What are lipids? --- p.1<br>Chapter 1.1.2 --- Function and structure of cholesterol --- p.1<br>Chapter 1.1.3 --- Function and classification of lipoprotein --- p.1<br>Chapter 1.2 -

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Kemp, Arika D. "Peripheral Venous Retroperfusion: Implications for Critical Limb Ischemia and Salvage." Thesis, 2014. http://hdl.handle.net/1805/6452.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Peripheral arterial disease is caused by plaque buildup in the peripheral arteries. Standard treatments are available when the blockage is proximal and focal, however when distal and diffuse the same type of the treatment options are not beneficial due to the diseased locations. Restoration of blood flow and further salvaging of the limb in these patients can occur in a retrograde manner through the venous system, called retroperfusion or arteriovenous reversal. Retroperfusion has been explored over the last century, where early side

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Nyathi, Leoba. "Rural women's perpectives of cardiovascular diseases: A study of Gwanda South Rural District, Zimbabwe." Thesis, 2019. http://hdl.handle.net/11602/1476.

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Institute for Gender and Youth Studies<br>PHDGS<br>Historically, the cardiovascular disease (CVD) has internationally been viewed as a man’s disease. This is witnessed by the high number of males who have fallen victim to this scourge. However, with rapid changes in today’s societies, the disease has increasingly become a public health concern among women also. This study aimed to explore rural women’s perspectives of CVD in Gwanda South Rural District. The study was guided by a feminist perspective where theories of gender such as social construction feminism, intersectionality and standpoint

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Xu, Haifeng. "Custom-Designed Biohybrid Micromotor for Potential Disease Treatment." 2019. https://monarch.qucosa.de/id/qucosa%3A71048.

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Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo transport. Their future application is, however, hindered by the low efficiency of drug encapsulation and their poor adaptability in physiological conditions. To address these challenges, one potential solution is to incorporate micromotors with biological materials as the combination of functional biological entities and smart artificial parts represents a manipulable and biologically friendly approach. This dissertation focuses on the development of custom-designed micromotors combined

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Noblet, Jillian Nicole. "Coronary perivascular adipose tissue and vascular smooth muscle function: influence of obesity." Diss., 2016. http://hdl.handle.net/1805/9815.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Factors released from coronary perivascular adipose tissue (PVAT), which surrounds large coronary arteries, have been implicated in the development of coronary disease. However, the precise contribution of coronary PVAT-derived factors to the initiation and progression of coronary vascular dysfunction remains ill defined. Accordingly, this investigation was designed to delineate the mechanisms by which PVAT-derived factors influence obesity-induced coronary smooth muscle dysfunction. Isometric tension studies of coronary arteries fro

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Moberly, Steven Paul. "Impaired cardiovascular responses to glucagon-like peptide 1 in metabolic syndrome and type 2 diabetes mellitus." Thesis, 2013. http://hdl.handle.net/1805/3216.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Recent advancements in the management of systemic glucose regulation in obesity/T2DM include drug therapies designed to utilize components of the incretin system specifically related to glucagon-like peptide 1 (GLP-1). More recently, GLP-1 has been investigated for potential cardioprotective effects. Several investigations have revealed that acute/sub-acute intravenous administration of GLP-1 significantly reduces myocardial infarct size following ischemia/reperfusion injury and improves cardiac contractile function in the settings o

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