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Journal articles on the topic 'Diseases of the optic nerve'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Hadhoum, N., J. Hodel, S. Defoort-Dhellemmes, et al. "Length of optic nerve double inversion recovery hypersignal is associated with retinal axonal loss." Multiple Sclerosis Journal 22, no. 5 (2015): 649–58. http://dx.doi.org/10.1177/1352458515598021.

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Objectives: To assess the association between optic nerve double inversion recovery (DIR) hypersignal length and retinal axonal loss in neuroinflammatory diseases affecting optic nerves. Methods: We recruited patients previously affected (> 6 months) by a clinical episode of optic neuritis (ON). We had 25 multiple sclerosis (MS) patients, eight neuromyelitis optica spectrum disorder (NMOSD) patients and two patients suffering from idiopathic caused ON undergo brain magnetic resonance imaging (MRI); including a 3-dimensional (3D) DIR sequence, optical coherence tomography (OCT) examination a

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2

Iester, Michele, and Elisa D’Alessandro. "Different IOP, different diseases?" Modeling and Artificial Intelligence in Ophthalmology 1, no. 2 (2016): 97–102. http://dx.doi.org/10.35119/maio.v1i2.25.

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Glaucoma is a chronic, progressive disease characterized by typical optic nerve head changes and visual field defects. These alterations are caused by an intraocular pressure (IOP) being too high for the wellbeing of the specific optic disc. Typical clinical findings in glaucoma patients include thinning of the optic disc rim (Fig. 1), loss of retinal nerve fibers in the inferior sector with subsequent visual field defects in the superior sector.

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3

Micera, Alessandra, Alessandro Lambiase, Paolo Rama, and Luigi Aloe. "Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis." Multiple Sclerosis Journal 5, no. 6 (1999): 389–94. http://dx.doi.org/10.1177/135245859900500i604.

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In this study we measured with a highly sensitive two-site immunoenzymatic assay the levels of nerve growth factor (NGF) in human optic nerve affected by multiple sclerosis (MS). The result of this study showed an elevated increase of NGF in the MS optic nerves, as compared to the level of NGF found in the optic nerves non-affected by this demyelinating disorder. Moreover, the results showed that the optic nerves also expressed trkA NGF receptor and NGFmRNA, most likely by oligodendrocytes, implying that NGF is locally produced and suggesting that the presence of NGF might be regulated by an a

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4

Viglianesi, A., M. Messina, R. Chiaramonte, et al. "An Interpretation of Optic Nerve Tortuosity." Neuroradiology Journal 22, no. 4 (2009): 381–85. http://dx.doi.org/10.1177/197140090902200403.

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Magnetic resonance imaging disclosed both optic nerve tortuosity and kinking in a 64-year-old man with orbital pain and monolateral abducens nerve palsy. The association between optic nerve tortuosity and abducens nerve palsy is often described in literature reports of idiopathic intracranial hypertension. However the diagnosis of idiopathic intracranial hypertension was excluded in our patient because of the absence of other signs such as papilledema (universally present in the cases of idiopathic intracranial hypertension), visual loss, headache and flattening of the posterior sclera. Other

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5

Margalit, Eyal, and Srinivas R. Sadda. "Retinal and Optic Nerve Diseases." Artificial Organs 27, no. 11 (2003): 963–74. http://dx.doi.org/10.1046/j.1525-1594.2003.07304.x.

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6

Rebhun, William C. "Retinal and Optic Nerve Diseases." Veterinary Clinics of North America: Equine Practice 8, no. 3 (1992): 587–608. http://dx.doi.org/10.1016/s0749-0739(17)30443-1.

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7

Ioyleva, E. E., A. Y. Safonenko, O. V. Golubeva, I. V. Potykun, and A. M. Mitrofanov. "The prospects for the diagnosis of optic neuritis in neuromyelitis optica." Russian ophthalmology of children, no. 1 (March 24, 2023): 45–50. http://dx.doi.org/10.25276/2307-6658-2023-1-45-50.

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The review presents data on the prospects for the diagnosis of optic neuritis in neuromyelitis optica (NMO). The differential diagnosis of NMO with multiple sclerosis and other autoimmune diseases is complicated by the similarity of the clinical manifestations of optic neuritis. The diagnostic approach, tactics of using and interpreting the results of modern laboratory, instrumental and hardware research methods are described. Additional diagnostic criteria are described for AQPR4-IgGseronegative patients with clinical symptoms of acute urinary tract infections. NMO is characterized by severe

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8

Meng, Zhaoyang, Ran You, Arif Mahmood, Fancheng Yan, and Yanling Wang. "Application of Proteomics Analysis and Animal Models in Optic Nerve Injury Diseases." Brain Sciences 13, no. 3 (2023): 404. http://dx.doi.org/10.3390/brainsci13030404.

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Optic nerve damage is a common cause of blindness. Optic nerve injury is often accompanied by fundus vascular disease, retinal ganglion cell apoptosis, and changes in retinal thickness. These changes can cause alterations in protein expression within neurons in the retina. Proteomics analysis offers conclusive evidence to decode a biological system. Furthermore, animal models of optic nerve injury made it possible to gain insight into pathological mechanisms, therapeutic targets, and effective treatment of such injuries. Proteomics takes the proteome as the research object and studies protein

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9

Buonfiglio, Francesco, Elsa Wilma Böhm, Norbert Pfeiffer, and Adrian Gericke. "Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?" Antioxidants 12, no. 7 (2023): 1465. http://dx.doi.org/10.3390/antiox12071465.

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Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber’s heredi

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10

Iskhakova, R. R., and F. R. Saifullina. "Diseases of the eye in chronic alcoholism." Kazan medical journal 94, no. 1 (2013): 101–5. http://dx.doi.org/10.17816/kmj1780.

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Chronic alcoholism is a disease affecting all the vital organs, including development of functional and organic eye disorders in 2-70% of cases. Alcoholic (ethanol) amblyopia with such features as slow gradient visual acuity decrease in both eyes (although visual acuity can decrease down do a very low grade, the complete blindness is rare) is among the disorders in patients with chronic alcoholism. Fundus of the eye at the beginning of the disease is normal in most of the cases, sometimes an optic nerve congestion and mild features of optic neuritis can be observed. Sometimes optic nerve hyper

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11

Yamamoto, Etsuko, Naoichi Horio, Hiroko Terasaki, and Yozo Miyake. "Evaluation of optic nerve function by flicker adaptation in optic nerve diseases." Neuro-Ophthalmology 26, no. 1 (2001): 35–41. http://dx.doi.org/10.1076/noph.26.1.35.8052.

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12

Nishimuta, Mari, and Kenji Kitahara. "Color discrimination in optic nerve diseases." Neuro-Ophthalmology 5, no. 4 (1985): 253–58. http://dx.doi.org/10.3109/01658108509004938.

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13

Mansour, Ahmad M., and Latif M. Hamed. "Racial variation of optic nerve diseases." Neuro-Ophthalmology 11, no. 6 (1991): 319–23. http://dx.doi.org/10.3109/01658109109036975.

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14

Levkovitch-Verbin, H. "Animal models of optic nerve diseases." Eye 18, no. 11 (2004): 1066–74. http://dx.doi.org/10.1038/sj.eye.6701576.

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15

R, Elif, MURAT BAYKARA, Adil AN, and Seda K. "Evaluation of the optic nerve with MRI histogram analysis in Behçet's disease." Annals of Medical Research 31, no. 1 (2024): 58. http://dx.doi.org/10.5455/annalsmedres.2024.11.312.

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Abstract Aim: The objective of the present study is to analyze whether the optic nerve is affected using histogram analysis on conventional MRI images in patients with Behçet’s disease. Material and Methods: Gender and age matched patients between the ages of 21 and 75 and a healthy control group were included in the study. Right and left optic nerves of all patients were evaluated by a neuroradiologist using T2-weighted MR images. The optic nerve examination data of the patients were evaluated by histogram analysis. The workstation was a 27 inch iMac computer manufactured by Apple Inc. Cupert

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16

Pateyuk, L. S., A. K. Drakon, V. M. Sheludchenko, and N. B. Korchazhkina. "The Role of Electrical Stimulation in Management of Retinal and Optic Nerve Degenerative and Dystrophic Disorders. Literature Review." Ophthalmology in Russia 18, no. 3S (2021): 673–80. http://dx.doi.org/10.18008/1816-5095-2021-3s-673-680.

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This article presents actual data on the retinal and optic nerve electrical stimulation. The physical basics of the electrical stimulation biological effect on cellular elements and nerve fibers are discussed. Ocular indications for electrical stimulation, as well as local and general contraindications are listed. Strategies of delivery and brief historical overview are given. The article presents current data on the electrical stimulation clinical effectiveness in the management of patients with degenerative and dystrophic diseases of the retina and optic nerve: age-related macular degenerati

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Khabazova, M. R., E. E. Ioyleva, N. A. Gavrilova, N. S. Gadzhieva, and T. V. Seryogina. "Combined corneal and optic nerve pathology." Russian ophthalmology of children, no. 1 (April 2, 2021): 28–32. http://dx.doi.org/10.25276/2307-6658-2021-1-28-32.

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A case with ophthalmological manifestations of two genetically determined diseases in one patient with a progressive decrease in visual functions is considered. The clinical picture and modern diagnostic methods necessary for the clinical diagnosis are reflected. The rare occurrence of combinations of congenital diseases of the cornea and optic nerve disc requires special attention during ophthalmological examination. Key words: corneal dystrophy, comorbidity, inherited diseases, optic nerve atrophy, optic disc drusen.

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18

Grishina, E. E., A. A. Ryabtseva, O. M. Andryuhina, and A. A. Kovrizhkina. "The role of optical coherence tomography in the diagnosis of the leukemic infiltration of the optic nerve and retina." Russian Ophthalmological Journal 14, no. 4 (2021): 46–51. http://dx.doi.org/10.21516/2072-0076-2021-14-4-46-51.

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Even though there are multiple diseases of the optic nerve and the retina in patients with hemoblastosis, their ophthalmoscopic picture is similar in many respects. The purpose of this study is to determine the role of optical coherence tomography (OCT) in the differential diagnosis of various manifestations of hemoblastosis in the fundus. Material and methods. From Jan. 2015 to Jan. 2019, 9 patients (5 men and 4 women aged 29 to 72) with hemoblastosis and lesions of the optic nerve and retina were examined. Results. 5 patients were diagnosed with leukemic infiltration of the optic nerve. The

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19

GÜNGÖR, Kıvanç, and Sevim Ayça SEYYAR. "Optic Nerve Head in Case of Increased Intraocular Pressure, High Intracranial Pressure and Increased Intracranial Pressure with Simultaneous Intraocular Pressure." Güncel Retina Dergisi (Current Retina Journal) 9, no. 2 (2024): 164–68. http://dx.doi.org/10.37783/crj-0451.

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The optic nerve, as part of the central nervous system, is surrounded by meninges and cerebrospinal fluid (CSF). This review discusses the effects of increased intraocular pressure (IOP), elevated intracranial pressure (ICP), and the simultaneous rise in both pressures on the optic nerve head (ONH). Increased IOP, caused by the balance of aqueous humor production and drainage, can lead to glaucomatous optic neuropathy, particularly through mechanical and ischemic damage to the lamina cribrosa. Elevated ICP, characterized by increased CSF pressure, can result in optic nerve edema, impairing axo

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Abdusalamova, Azizakhon Ibrohimjon kizi. "MODERN TREATMENT METHODS FOR CHRONIC ISCHAEMIC OPTICAL NEUROPATHY OF VASCULAR ORIGIN." CENTRAL ASIAN JOURNAL OF EDUCATION AND INNOVATION 1, no. 1 (2022): 10–14. https://doi.org/10.5281/zenodo.7306617.

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Vascular diseases of the optic nerve are one of the most important problems of ophthalmology. In spite of the undoubted progress achieved in the recent decades in diagnostics and treatment of ophthalmological diseases the number of patients with optic nerve affection of vascular genesis is increasing. Modern methods of treatment of chronic ischemic optic neuropathy of vascular genesis are analyzed in the article.

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21

Poonia, Kavita, Rajeev Tuli, Gaurav Sharma, and Amit Bhardwaj. "To study visual evoked potential in patients with optic nerve diseases." Journal of Clinical Ophthalmology and Research 12, no. 2 (2024): 105–9. http://dx.doi.org/10.4103/jcor.jcor_58_22.

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Background: To study Visual Evoked Potential in patients with Optic Nerve diseases. Study design and settings: Cross – Sectional study. Material and Methods: 72 patients were included in our study, aged 12 years and above, diagnosed as optic nerve diseases like optic neuritis, Nonarteritc ischemic optic neuropathy (NAION), hereditary, nutritional and compressive optic neuropathy etc. Flash and Pattern VEPs were used. VEP amplitude and latency were noted. Results: Out of total 144 eyes, 107 eyes were affected. Ethambutol induced Toxic optic neuropathy was the most common etiology, followed by s

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22

Josef, Finstere. "Whole-Brain Contrast-Enhanced 3D TSE T1WI Should Be Preferred Over Orbits Contrast-Enhanced 2D Coronal T1WI for the Detection of Optic Nerve Enhancement in Patients with Acute Vision Loss." Sarcouncil Journal of Medical Series 3, no. 8 (2024): 27–28. https://doi.org/10.5281/zenodo.13370220.

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We were interested to read the article by Prillard <em>et al</em>. on a retrospective study comparing contrast-enhanced 3D TSE-T1WI with contrast-enhanced coronal 2D T1WI of the orbits for the detection of optic nerve enhancement in patients with acute vision loss but without obvious ophthalmologic involvement [Prillard, D. <em>et al</em>., 2024]. It was found that there was a strong agreement between 3D TSE-T1WI and 2D coronal T1WI with regard to the detection of optic nerve enhancement [Prillard, D. <em>et al</em>., 2024]. In patients with canalicular involvement, 3D TSE-T1WI had a higher se

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LIBBY, RICHARD T., MICHAEL G. ANDERSON, IOK-HOU PANG, et al. "Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration." Visual Neuroscience 22, no. 5 (2005): 637–48. http://dx.doi.org/10.1017/s0952523805225130.

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The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our

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YILDIZ, Veysi. "Optical Coherence Tomography and Optical Coherence Tomography Angiography in Optic Nerve Disorders." Güncel Retina Dergisi (Current Retina Journal) 9, no. 2 (2024): 187–95. http://dx.doi.org/10.37783/crj-0454.

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Optic nerve disorders encompass a wide range of diseases. While it may be an isolated disease, such as optic disc drusen, it may also occur as a symptom of pathology in the central nervous system, such as multiple sclerosis. Optical coherence tomography (OCT) is an important auxiliary test used in optic nerve disorders as it allows cross-sectional imaging of the retina and optic nerve head at high resolution. OCT is used in the diagnosis of optic nerve disorders, evaluation of response to treatment, and prediction of visual prognosis by measuring retinal layers such as the ganglion cell layer

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Čelakovský, P., J. Vokurka, L. Školoudík, and J. Růžička. "Optic neuritis and paranasal sinus diseases." Open Medicine 6, no. 1 (2011): 117–19. http://dx.doi.org/10.2478/s11536-010-0069-7.

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AbstractThe relationship of sinusitis and paranasal sinus mucoceles to optic neuritis (ON) remains a challenge for both the otolaryngologist and the ophthalmologist. Currently, ON is assumed to be a rare complication of paranasal sinus diseases. Three new cases of ON associated with paranasal sinus diseases are described. We postulate different pathophysiologic mechanisms of ON in our three patients: compression of optic nerve due to sphenoid mucocele in the first patient; extension of bacterial infection to the optic nerve in the second patient; and invasion of aspergillosis to the orbital ap

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Olefir, I. S. "THE EFFICIENCY OF CYTOKINE THERAPY IN TREATING DEGENERATIVE DISEASES OF THE OPTIC NERVE." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 2 (2024): 40–43. http://dx.doi.org/10.31718/2077-1096.24.2.40.

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Degenerative diseases of the optic nerve can result from a variety of causes, including increased intraocular pressure, impaired blood supply, and physical trauma (e.g. due to retroorbital hemorrhage and traumatic brain injury). As the optic nerve is composed of retinal ganglion cell axons, primary retinal lesions (especially those affecting the ganglion cells and nerve fiber layers) often result in concomitant optic nerve pathology, including degeneration. The aim of this study is to assess the effectiveness of treating degenerative diseases of the optic nerve with the drug cytocholine based

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Paudel, Sharma, Sweta Joshi, Durga Pandey, and Prakash Kayastha. "Measurement of Optic Nerve and Optic Nerve Sheath Diameter in MRI Brain." Journal of Institute of Medicine Nepal 45, no. 3 (2023): 36–41. http://dx.doi.org/10.59779/jiomnepal.1277.

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Introduction: Many diseases affect the size of the optic nerve and optic nerve sheath, measurement of which is important for the diagnosis and treatment of different pathologies of the brain and orbit. This study aimed to measure the diameter of the optic nerve and optic nerve sheath in MRI brain examinations. We also studied their variation according to age, gender, and laterality. Methods: This cross-sectional, quantitative study was performed in the Radiology Department of Tribhuvan University Teaching Hospital (TUTH). The diameter of the optic nerve and optic nerve sheath were measured in

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Zăvoi, Andreea A., and Andra Elena Enache. "Glaucoma in Dogs." Cluj Veterinary Journal 26, no. 3 (2021): 8–22. http://dx.doi.org/10.52331/cvj.v26i3.34.

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Glaucoma is a group of diseases commonly defined by an increased intraocular pressure (IOP) which interferes with normal function of the optic nerve and retina. Characteristic changes of glaucoma include reduced axoplasmic flow in the optic nerve head, retinal ganglion cells death, cupping of the optic disc and visual damage or blindness due to retinal and optic nerve atrophy.  Glaucoma with a normal intraocular pressure (normotensive glaucoma) has been described in human patients, however not in animals so far.

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Astakhov, Yu S., S. N. Tultseva, and A. I. Titarenko. "The role of endothelium dysfunction in the pathogenesis of vascular ocular diseases." Regional blood circulation and microcirculation 15, no. 4 (2016): 5–16. http://dx.doi.org/10.24884/1682-6655-2016-15-4-5-16.

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Vascular endothelium plays the key role in the control of vascular tone due to release of vasoactive substances. Reduction of retinal, choroidal and optic nerve head blood flow is above all a result of misbalance between endothelium-produced vasoconstrictors and vasodilators mainly ET-1 and NO. NO is involved in the maintenance of choroidal, optic nerve head and retinal basal blood flow. Combination of NO deficiency and overproduction of ET-1 is accompanied by diabetic retinopathy, glaucomatous optic nerve atrophy, retinal vascular occlusion and other ocular disease. In the review, the role of

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Saidasheva, E. I. "NEURORETINOPROTECTION IN TREATMENT AND REHABILITATIONOF EYE DISEASES IN CHILDREN’S AGE." HERALD of North-Western State Medical University named after I.I. Mechnikov 9, no. 3 (2017): 24–31. http://dx.doi.org/10.17816/mechnikov20179324-31.

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Presented of own long-term experience and the generalized results of the researches devoted to use of domestic drugs of peptide structure in complex therapy of a number of diseases of an optic nerve and a retina at patients of children's age. Clinical efficiency of a retinalamin as retinoprotector and cortexin as neuroprotector in treatment and rehabilitation the disabling diseases shown: atrophy of the optic nerve, retinopathy of prematurity and degenerative myopia.

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Bhatt, Jyoti. "Optic nerve head: A diagnostic Saga!" Indian Journal of Clinical and Experimental Ophthalmology 10, no. 3 (2024): 603–8. http://dx.doi.org/10.18231/j.ijceo.2024.104.

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Optic nerve head assessment can be a window to diagnosing a plethora of diseases. It can provide us with a hint into glaucoma as well as many non glaucomatous optic neuropathies associated with neurological conditions like space occupying lesion, raised intracranial tension, demyelination, & systemic diseases like uncontrolled hypertension, diabetes, vascular auto- dysregulation, as well as toxic dietary influences & deficiencies, which can have serious consequences in terms of not just a threat to vision, but also systemic morbidity & mortality.

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Aghsaei Fard, Masoud. "Clinical Applications of Optical Coherence Tomography in Ophthalmology." Journal of Guilan University of Medical Sciences 32, no. 1 (2023): 2–7. http://dx.doi.org/10.32598/jgums.32.1.2024.2.

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I read the study conducted by Alizade et al. [1] which was interesting. I need to indicate some points about the use of Optical Coherence Tomography (OCT) in ophthalmology and optic nerve diseases. As Alizadeh et al. [1] stated, OCT has become popular for the diagnosis and follow-up of retinal and optic nerve diseases due to its high reproducibility. In this letter, I discuss the role of OCT in optic nerve ischemia and share my experiences in this field. Then, I review the role of OCT angiography (OCT-A) and recent developments in this field, as well as the role of artificial intelligence in o

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Kobak, Joanna, Magdalena Tyczyńska, Alicja Forma, et al. "Optic nerve neuropathies – causative factors, methods of diagnostics, current and future possibilities of treatment." Journal of Education, Health and Sport 12, no. 4 (2022): 44–61. http://dx.doi.org/10.12775/jehs.2022.12.04.004.

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Introduction: Optic neuropathies are a broad group of diseases in which the dominant disturbance is damage to the optic nerve, often irreversible. Underlying causes of neuropathy are both genetic and environmental. Despite limited treatment options, much research is currently being done on substances that could improve optic nerve function and alleviate the clinical consequences of optic nerve damage. Purpose: This article describes current findings in both the optic nerve neuropathy pathophysiology and diagnosis of the disorder, as well as treatment options and future perspectives.&#x0D

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Machida, Shigeki. "Clinical Applications of the Photopic Negative Response to Optic Nerve and Retinal Diseases." Journal of Ophthalmology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/397178.

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The photopic negative response (PhNR) in response to a brief flash is a negative-going wave following the b-wave of the cone electroretinogram (ERG) that is driven by retinal ganglion cells (RGCs). The function of RGCs is objectively evaluated by analysing the PhNR. We reviewed articles regarding clinical use of the PhNR. The PhNR was well correlated with the visual sensitivity obtained by standard automated perimetry and morphometric parameters of the inner retina and optic nerve head in optic nerve and retinal diseases. Moreover, combining the PhNR with focal or multifocal ERG techniques ena

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Bambo, M. P., E. Garcia-Martin, J. M. Larrosa, V. Polo, L. E. Pablo, and M. González-de la Rosa. "Evaluation of optic nerve perfusion in optic neuropathies and neurodegenerative diseases." Archivos de la Sociedad Española de Oftalmología (English Edition) 90, no. 4 (2015): 153–55. http://dx.doi.org/10.1016/j.oftale.2015.04.002.

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Ferreira, João Marcos Campos, Cristiane Rebello Gomes de Souza Fontes, Carolina do Val Ferreira Ramos, and Osvaldo J. M. Nascimento. "Optic neuritis in demyelinating diseases: study of 38 cases." Arquivos de Neuro-Psiquiatria 82, no. 12 (2024): 001–7. https://doi.org/10.1055/s-0044-1792093.

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Abstract Background Optic neuritis is an inflammation of the optic nerve caused by genetic factors, external influences, and the activation of cross-reactive immune responses to infections. Objective To describe the clinical and epidemiological characteristics of patients presenting optic neuritis as the initial symptom of some demyelinating diseases, divided among multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated disorders (MOGADs). Methods Thirty-eight patients who had optic neuritis as their

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Nizamova, Shakhnoza Zariboy Kizi. "PECULIARITIES OF THE COURSE IN PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA WITH HYPERTENSION." zamonaviy dunyoda innovatsion tadqiqotlar 2, no. 11 (2023): 34–35. https://doi.org/10.5281/zenodo.7793779.

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Glaucoma is a group of diseases differing in pathophysiology, risk factors, manifestations, treatment and prognosis. Progressive degeneration of the optic nerve with the loss of retinal ganglion cells, thinning of the retinal nerve fiber layer and progressive optic disc excavation are their common feature.

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Dr., Nimmy Davis*. "NEUROMYELITIS OPTICA SPECTRUM DISORDER: A CASE REPORT." World Journal of Pharmaceutical Science and Research 2, no. 4 (2023): 18–20. https://doi.org/10.5281/zenodo.10897592.

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Neuromyelitis optica spectrum disorder (NMOSD), formerly known as neuromyelitis optica (NMO) or Devic’s syndrome or Devic’s disease, was initially considered as part of multiple sclerosis (MS) because the symptoms were considered overlapping. But now, it is known that the pathophysiology of these two diseases is different.<sup>[2] </sup>Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease that causes severe demyelination, especially in the optic nerve and spinal cord with typical clinical manifestations of acute optic neuritis and transverse myelitis. The symptom

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Gaspar, A. Z., J. Flammer, and PH Hendrickson. "Influence of Nifedipine on the Visual Fields of Patients with Optic-Nerve-Head Diseases." European Journal of Ophthalmology 4, no. 1 (1994): 24–28. http://dx.doi.org/10.1177/112067219400400105.

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Calcium-channel blockers have long been employed in coronary disease, and recent investigations have indicated their efficacy in improving the visual field in low-tension glaucoma or presumed vasospasm, possibly by enhancing ocular circulation. We evaluated the short-term influence of a typical calcium-channel blocker, nifedipine, on 59 patients with visual-field defects, some with optic-nerve-head pathology (n = 38) and some with normal-appearing optic nerve heads (n = 21). On the average, a statistically significant improvement of 1.2 dB was observed. Different types of patients, however, be

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Marmoy, Oliver R., and Suresh Viswanathan. "Clinical electrophysiology of the optic nerve and retinal ganglion cells." Eye 35, no. 9 (2021): 2386–405. http://dx.doi.org/10.1038/s41433-021-01614-x.

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AbstractClinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised techniques. In this review, we describe these electrophysiological techniques and their application in diseases affecting the optic nerve and retinal ganglion cells with the exception of glaucoma. The disease groups discussed include hereditary, compressive, toxic/nutritional, traumatic, vascular, inflammatory and intracranial causes f

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Tokuhisa, Teruaki, Takaaki Hayashi, Shusaku Omoto, Ai Kozaki, Toshu Inoue, and Tadashi Nakano. "Dysthyroid Optic Neuropathy Complicated by Neuromyelitis Optica Spectrum Disorder: A Case Report." Case Reports in Ophthalmology 15, no. 1 (2024): 621–27. http://dx.doi.org/10.1159/000540496.

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Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder that principally targets the central nervous system, specifically the spinal cord and optic nerves. NMOSD is often associated with thyroid pathologies such as Graves’ disease or Hashimoto’s thyroiditis. Thyroid eye disease (TED) is an autoimmune condition characterized by inflammation and hypertrophy of the extraocular muscles. Dysthyroid optic neuropathy (DON), a critical complication of TED, may lead to irreversible visual loss. We report a case of DON complicated by NMOSD. Case Presentation: We report a c

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Shimo-Oku, Masashi, Shigeo Miyazaki, Kahoru Shiraki, Taeko Sugimoto, and Haruyuki Sotani. "Optic nerve involvement in posterior paranasal sinus diseases." Neuro-Ophthalmology 9, no. 3 (1989): 147–55. http://dx.doi.org/10.3109/01658108909010468.

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Aliyeva, G. A. "EVALUATION OF OPTIC NERVE CHANGES IN PATIENTS WITH MULTIPLE SCLEROSIS USING OPTICAL COHERENCE TOMOGRAPHY." National Journal of Neurology 1, no. 23 (2023): 90. http://dx.doi.org/10.61788/njn.v1i23.16.

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Introduction. Multiple sclerosis (MS) is an inflammatory disease of the nervous system, characterized by damage to the myelin sheath of nerve cells in the brain and spinal cord. 60% of patients suffering from MS have visual impairments. Optical coherence tomography (OCT) examination helps to analyse neurodegeneration in patients with multiple sclerosis. Thinning of the retinal nerve fibre layer (RNFL) is observed in these patients, which is greater than the thinning observed in normal age-related thinning. Material and methods. During the study, 20 patients were examined. Of these 7 patients (

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Юсупов, А. Ф., М. Х. Каримова, Д. К. Махкамова та М. С. Мухиддинова. "Васкулиты зрительного нерва: обзор литературы". Офтальмология. Восточная Европа 15, № 2 (2025): 234–47. https://doi.org/10.34883/pi.2025.15.2.024.

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Цель работы – проведение анализа литературных данных о васкулите зрительного нерва. Васкулиты зрительного нерва представляют собой редкую, но клинически значимую группу заболеваний, характеризующихся воспалительным поражением сосудов, которые снабжают зрительный нерв. В литературе они известны под различными названиями, такими как папиллофлебит, васкулит диска зрительного нерва, ангиит, флебит и другие. Эти заболевания могут приводить к значительным зрительным нарушениям, вплоть до полной слепоты. Васкулиты зрительного нерва могут возникать в любом возрасте и поражать как мужчин, так и женщин.

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Vorobyeva, I. V. "Prediction of the course of primary open-angle glaucoma in combination with diabetic retinopathy using a mathematical model." E3S Web of Conferences 224 (2020): 03021. http://dx.doi.org/10.1051/e3sconf/202022403021.

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It is possible to accurately diagnose diseases in the early stages using optical coherence tomography. A mathematical model has been developed for two diseases: glaucoma and diabetic retinopathy. The model takes into account digital data of ophthalmological equipment obtained from the optic nerve disk and macular area. Criteria that take into account the thickness of the macular zone and the parameters of the optic nerve disc were developed (integral volume and area of the neuroretinal rim, the area of the optic disc excavation). The proposed mathematical model gives the opportunity to predict

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GÜLMEZ SEVİM, Duygu, and Furkan OZER. "Posterior Optic Neuropathies." Güncel Retina Dergisi (Current Retina Journal) 9, no. 2 (2024): 152–59. http://dx.doi.org/10.37783/crj-0449.

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Posterior optic neuritis refers to a group of rarer diseases of optic neuritis. Similar to anterior optic neuropathies, they can cause decreased visual acuity and optic nerve dysfunction. Although they can be caused by various causes, corticosteroids are important in their treatment. A multidisciplinary approach with ophthalmologists may be required in their management.

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Kang, Eugene Yu-Chuan, Pei-Kang Liu, Yao-Tseng Wen, et al. "Role of Oxidative Stress in Ocular Diseases Associated with Retinal Ganglion Cells Degeneration." Antioxidants 10, no. 12 (2021): 1948. http://dx.doi.org/10.3390/antiox10121948.

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Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most common neurodegenerative disorder that causes irreversible blindness worldwide. It is characterized by visual field defects and progressive optic nerve atrophy. The underlying pathophysiology and mechanisms of RGC degeneration in several ocular diseases remain largely unknown. RGCs are a population of central nervous system neurons, with their soma located in the retina and long axons that extend through the optic nerve to form distal terminals and connections in the brain. Because of this unique cytoarchitect

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Ioyleva, E. E., A. А. Bratchuk, and M. R. Khabazova. "Toxic damage of the optic nerve by smoking a tobacco mixture using a hookah." Russian Ophthalmological Journal 15, no. 3 (2022): 157–62. http://dx.doi.org/10.21516/2072-0076-2022-15-3-157-162.

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Recent years have seen an increase in tobacco mixture smokers using hookahs. Dangerous substances released during smoking cause substantial harm to the entire body, and bring about visual impairment with toxic optical neuropathy. Eye structures which are the most susceptible to toxin damage are the cells of the optic nerve and retina. Substances released when smoking hookah tobacco mixtures have a direct neurotoxic impact on the optic nerve and cause metabolic damage to the retinal nerve fiber layer and ganglion cells. Timely detection of this damage is complicated by the similarity of its cli

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Wong, Kimberly A., and Larry I. Benowitz. "Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Injury: Role of Inflammation and Other Factors." International Journal of Molecular Sciences 23, no. 17 (2022): 10179. http://dx.doi.org/10.3390/ijms231710179.

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The optic nerve, like most pathways in the mature central nervous system, cannot regenerate if injured, and within days, retinal ganglion cells (RGCs), the neurons that extend axons through the optic nerve, begin to die. Thus, there are few clinical options to improve vision after traumatic or ischemic optic nerve injury or in neurodegenerative diseases such as glaucoma, dominant optic neuropathy, or optic pathway gliomas. Research over the past two decades has identified several strategies to enable RGCs to regenerate axons the entire length of the optic nerve, in some cases leading to modest

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Yoshida-Hata, Natsuyo, Naomichi Katai, and Toshiyuki Oshitari. "Ophthalmic Manifestations of Hematopoietic Malignancy." Case Reports in Ophthalmological Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/6074968.

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Purpose. To report the ocular findings in patients with hematopoietic malignancy with optic nerve involvement and abducens nerve palsy.Methods. The medical records of all cases of hematopoietic cancer with ophthalmic involvements seen in the Department of Ophthalmology of the National Center for Global Health and Medicine between 2009 and 2014 were reviewed.Results. Eight patients with hematopoietic cancer with optic nerve invasion or abducens nerve palsy were studied. The primary diseases were 3 cases of multiple myeloma, 1 case of acute lymphocytic leukemia, 1 case of follicular lymphoma, an

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