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Journal articles on the topic 'Disintegrant'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Azubuike, Chukwuemeka P., Uloma N. Ubani-Ukoma, Abiola R. Afolabi, and Ibilola M. Cardoso-Daodu. "Evaluation of super-disintegrant potential of acid-modified starch derived from Borassus aethiopum (Aracaceae) shoot in paracetamol tablet formulations." Tropical Journal of Pharmaceutical Research 19, no. 3 (2020): 459–65. http://dx.doi.org/10.4314/tjpr.v19i3.1.

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Purpose: To evaluate the super-disintegrant potentials of acid modified Borassus aethiopum starch (AMS) in comparison with native starch (NS) and commercial disintegrant sodium starch glycolate (SSG). Methods: Compatibility of AMS with paracetamol powder was evaluated using Fourier transform infrared (FTIR) spectrophotometry. Seven batches of paracetamol granules and tablets were prepared by wet granulation. AMS and NS were employed as disintegrants at concentrations of 2.43, 4.86 and 9.72 %w/w, respectively while 4.86 %w/w SSG was used as standard disintegrant. All the batches of the gr

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Soraya, M., R. P. G. Putri, H. Purwoto, et al. "Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant." IOP Conference Series: Earth and Environmental Science 1377, no. 1 (2024): 012003. http://dx.doi.org/10.1088/1755-1315/1377/1/012003.

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Abstract Recently, seaweed-based capsule shells have become more popular because of their reliable quality and animal-free source. But these shells’ prolonged disintegration times are a common problem. This research aims to look for formulations with disintegrant substitution or a combination of several disintegrants to obtain capsule shells that disintegrate quickly. Several studies have explored the incorporation of additional disintegrants such as Polyvinylpyrrolidone (PVP) K-30, Sodium starch glycolate (primogel), Croscarmellose sodium (SSC), and Sodium carboxymethylcellulose (Na-CMC) to a

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Onwuatuegwu, Onyinye D., Chukwuemeka P. Azubuike, Sinmisola Aloko, Modupe O. Ologunagba, and Cecilia I. Igwilo. "Characterization and Disintegrant Potential of Phosphorylated Tiger Nut (Cyperus esculentus) Starch in Immediate Release Ibuprofen Tablet Formulation." Dhaka University Journal of Pharmaceutical Sciences 18, no. 1 (2019): 21–29. http://dx.doi.org/10.3329/dujps.v18i1.41423.

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The study was aimed at evaluating the physicochemical properties of phosphorylated tiger nut starch (TNP) and its disintegrant properties in immediate release ibuprofen tablets. Native tiger nut starch (TNS) was modified by phosphorylation with disodium hydrogen orthophosphate at 130oC and its physicochemical properties were evaluated. Ibuprofen tablets were formulated with TNP and sodium starch glycolate (SSG) at concentrations of 5.0, 7.5, 10.0 and 15.0% as disintegrants. Phosphorylation of TNS led to improved flow properties and swelling and hydration capacities among other changes in the p

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Fahmansyah, Lingga Pratama, Agus S, and Suparman. "REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 857–76. http://dx.doi.org/10.37874/ms.v9i3.1292.

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This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentratio

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J.N., Oraeluno, Obasi J.C, Bamigbola E.A, and Joseph B.A. "Production and Evaluation of Disintegrant Properties of Microcrystalline Cellulose Derived from SaccharumofficinarumL (Poaceae) in Metronidazole Based Formulation." International Journal of Pharmaceutical Sciences and Medicine 6, no. 4 (2021): 42–51. http://dx.doi.org/10.47760/ijpsm.2021.v06i04.004.

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The aim of the study was to produce microcrystalline cellulose from Saccharumofficinarum and to evaluate its use as a disintegrant in metronidazole tablet formulation. Cellulose was produced and characterized. This was followed by a comparative characterization of the tablets formulated by using Saccharumofficinarummicrocrystalline cellulose (SO-MCC), maize starch and crosscarmellose sodium (Ac-di-sol®) as disintegrants. The granules were evaluated for flow properties and the tablet evaluated for hardness, friability, disintegration and dissolution properties. For disintegration studies, the d

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Patel, Ashok, and Pradeep Vavia. "Evaluation of Synthesized Cross Linked Polyvinyl Alcohol as Potential Disintegrant." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 2 (2010): 114. http://dx.doi.org/10.18433/j3xs3d.

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PURPOSE: The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant.  METHODS: Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of the disintegrant (including sedimentation volume, hydration capacity, specific surface area and bulk and tap density) were determined and compared to the known disintegrants. Characterization was ca

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Muhangi, Rodgers, Albert N. Onchweri, Maniga Josephat, Tenywa Mercy, Jacqueline Njeri Muchiri, and Ugwu Okechukwu Paul-Chima. "Effect of Musa acuminata Starch concentration on the Disintegrant Activity of Paracetamol Tablets." IDOSR JOURNAL OF APPLIED SCIENCES 8, no. 2 (2023): 122–33. http://dx.doi.org/10.59298/idosr/2023/10.1.7009.

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Today, tablets are one of the most widely used pharmaceutical dosage forms. Both active pharmaceutical ingredients (API) and inactive ingredients such as disintegrants are found in pharmaceutical dosage forms. Disintegrants are essential for dissolving the tablet into small particles and increasing the surface area of the API when it is exposed to gastrointestinal fluids. As a result, choosing the right type and concentration of disintegrant is often the most important aspect in determining tablet quality. Effect of Musa acuminata starch concentration on the disintegrant activity of paracetamo

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Immaculate, Ssemakula. "Comparative Evaluation of Sweet Potato and Peas Starches as Disintegrants in the Foundation of Paracetamol Tablets." IDOSR JOURNAL OF SCIENTIFIC RESEARCH 8, no. 3 (2023): 84–98. http://dx.doi.org/10.59298/idosrjsr/2023/00.7.6000.

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Starch is used as an excipient in pharmaceutical dosage forms such as binder, diluent, disintegrant, absorbent, glidant and sweetener. Starch also has industrial applications as a viscosifier, defoaming and emulsifying agent. However, most of the starch used for these purposes is corn starch and is obtained by importation into Uganda from other countries, which results in a lot of money being utilized in importation of the corn starch which affects the cost of the final products formulated from this starch. The purpose of this research was to determine the disintegrant properties of sweet pota

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Puri, Abhijeet Vishnu, Prakash D. Khandagale, Ankita U. Tiwari, Rekhadevi H. Chaudhary, and Sonam B. Kartan. "Synthesis and Physicochemical Characterization of Banana Starch Tartrate and its Application as Disintegrant in Telmisartan Tablets." Journal of Drug Delivery and Therapeutics 10, no. 3 (2020): 65–72. http://dx.doi.org/10.22270/jddt.v10i3.4089.

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The present investigation was aimed to isolate banana starch (BS), synthesis of banana starch tartrate (BST), characterization, and application as a novel disintegrant in telmisartan tablets. Starch tartrate was synthesized by the esterification process by the treatment of tartaric acid on the backbone of the BS. Synthesized BST was found to be fine, slightly free-flowing and crystalline powder. The synthesized BST was subjected to Scanning Electron Microscopy (SEM) and micrometric evaluation. Flow properties of BS and BST were determined as an angle of repose, bulk density, tapped density, Ca

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Okpanachi, Gideon O., Amodu Yakubu, Hassan Musa, and Ademola R. Oduola. "Evaluation of millet (Pennisetum glaucum and Pennisetum americanum) starches as tablet disintegrants." Journal of Science and Practice of Pharmacy 5, no. 2 (2018): 231–39. http://dx.doi.org/10.47227/jsppharm.v5i2.1.

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Purpose: This study is aimed at evaluating the disintegrant property of locally sourced millet (Pennisetum glaucum (PG) and Pennisetum americanum (PA)) starches in comparison with maize starch BP (MS). Methods: The millet starches were extracted by the wet extraction method and compared with MS as disintegrants at various concentrations (0-12.5%w/w) in the preparation of paracetamol granules and tablets. The granules were analyzed for their physicochemical properties such as; flow rate, moisture content, angle of repose, Carr’s index (CI), Hausner ratio (HR) and sieve analysis while the tablet

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Raziya, Begum Sheikh. "Development and Assessment of Naproxen Mouth Dissolving Tablets." medtigo Journal of Pharmacology 1, no. 1 (2024): e13377773. https://doi.org/10.5281/zenodo.13377773.

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The market demand for orally disintegrating tablets has experienced a significant surge over the past decade. This intervention is particularly beneficial for geriatric and pediatric patients who experience challenges in ingesting traditional tablets and capsules. The utilization of a fast dissolving or fast disintegrating dosage form confers advantages to patients in this context. Fast dissolvable or fast disintegrating dosage forms are designed to rapidly disintegrate upon exposure to saliva, resulting in accelerated drug release within the oral cavity. The administration of fast-disintegrat

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12

Zheng, Audrey Yi, Paul Wan Sia Heng, and Lai Wah Chan. "Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure." Pharmaceutics 14, no. 12 (2022): 2725. http://dx.doi.org/10.3390/pharmaceutics14122725.

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Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet disintegratability to gain deeper insights into superdisintegrant sensitivity and function. Tablets with either sodium starch glycolate or crospovidone as disintegrant were prepared at various compaction pressures and subjected to the disintegration test using different medium temperatures. Preheating o

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Vishwasrao, S. S., and A. Jadhav. "STUDIES ON FORMULATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS USING MUSA ACUMINATA AS A NATURAL DISINTEGRANT FOR PAEDIATRIC USE." INDIAN DRUGS 53, no. 12 (2016): 55–58. http://dx.doi.org/10.53879/id.53.12.10628.

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The aim of the present study was to optimize an orally disintegrating tablet of ibuprofen (~100mg) using Musa acuminata (dehydrated banana powder) as a natural super disintegrant. In this work, dehydrated banana powder was used as pharmaceutical excipient because of natural origin and high nutrition properties for paediatric formulation. These tablets were prepared by direct compression technique and compared with formulations made by using synthetic super disintegrants Croscarmellose sodium, micro crystalline cellulose and Cross povidone. FTIR studies of formulations have shown no interaction

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Okunlola, Adenike, and Oluwatoyin A. Odeku. "Effects of Water Yam and Corn Starches on the Interacting Variables Influencing the Disintegration of Chloroquine Phosphate Tablets." Dhaka University Journal of Pharmaceutical Sciences 10, no. 1 (2012): 21–28. http://dx.doi.org/10.3329/dujps.v10i1.10011.

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The individual and effects of interaction of nature (X) and concentration (Y) of disintegrant and the relative density (Z) on the mechanical and release properties of chloroquine phosphate tablets were studied using a 23 factorial experimental design. Water yam starch (“low” level) and corn starch (“high” level) were used as disintegrants at concentrations of 5.0% and 20.0% w/w. The mechanical properties were assessed using the crushing strength (CS) and friability (F) and the release properties by the disintegration time (DT) and dissolution time (t80). Increasing the concentration of disinte

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15

Than, Yee Mon, Sarisa Suriyarak, and Varin Titapiwatanakun. "Rheological Investigation of Hydroxypropyl Cellulose–Based Filaments for Material Extrusion 3D Printing." Polymers 14, no. 6 (2022): 1108. http://dx.doi.org/10.3390/polym14061108.

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The rheological properties of drug–polymer mixtures have a significant influence on their processability when using transformative techniques, such as hot-melt-extrusion and material-extrusion 3D printing; however, there has been limited data on printable systems. This study investigated the rheological properties of 17 formulations of successful printed tablets for both immediate and controlled release. Hydroxypropyl cellulose was used in various ratios to obtain printable filaments in combination with various drugs (indomethacin or theophylline), polymers and disintegrants. The complex visco

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Prasada Kumar, Mahapatra Abikesh, Puranik Sangamesh B, Panigrahy Subodhkant, Paul Basudev Paul, and Ekambaram Vijay Kumar. "Application of Lepidium sativum Seed Mucilage as a Disintegrant in Pharmaceuticals Formulations: Exploring the Myth vs. the Reality." International Journal of Current Research and Review 13, no. 22 (2021): 129–32. http://dx.doi.org/10.31782/ijcrr.2021.132223.

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Introduction: The uses of Lepidium sativum seed mucilage (LSSM) as a disintegrant in various pharmaceutical formulations were already discussed. Researchers claimed that the different functional properties of the seed mucilage of Lepidium sativum enable it to use as a natural disintegrant. Furthermore, scientific research on the disintegrant activity of the LSSM has revealed that it could be effectively used as an alternative to synthetic disintegrant. However, certain factors restrict its use as a disintegrant on the large scale. Aim: In the current scientific discussion, we technically analy

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Nabila Nabila and Sry Ulina Karo-Karo. "Exploring natural disintegrant as alternative excipients sources for tablet formulation: A systematic review." International Journal of Science and Research Archive 13, no. 2 (2024): 3296–305. https://doi.org/10.30574/ijsra.2024.13.2.2530.

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Optimizing the disintegration and dissolution of orally administered tablets is crucial for releasing active pharmaceutical ingredients (APIs) for absorption. This review explores disintegrant research, focusing on natural super disintegrants and co-processed excipients that collected from 2010-2024. Natural disintegrants such as Silicified Oryza Sativa Starch, Plantago ovata mucilage, and gum karaya show promising results. Silicified Oryza Sativa Starch enhances paracetamol tablet disintegration, while Plantago ovata mucilage outperforms Crosspovidone. Gum karaya offers a cost-effective, bioc

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Ilango, Kumbakonam Balachandran, Senguttuvan Gowthaman, Kumbakonam Ilango Seramaan, et al. "Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient." Polymers 14, no. 1 (2022): 215. http://dx.doi.org/10.3390/polym14010215.

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Natural eco-friendly materials are recently employed in products to replace synthetic materials due to their superior benefits in preserving the environment. The herb Coccinia grandis is widely distributed in continents like Asia and Africa and used traditionally to treat fever, leprosy, asthma, jaundice, and bronchitis. Mucilage of Coccinia grandis was accordingly extracted, isolated by a maceration technique, and precipitated. The mucilage was evaluated for its physicochemical, binding, and disintegrant properties in tablets using paracetamol as a model drug. The crucial physicochemical prop

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Binti Sarun, Nur Hanisah, Archadian Nuryanti, and Ika Dewi Ana. "The Effect of Chitosan Concentration on Disintegration Time of Amoxicillin Tablet." Key Engineering Materials 884 (May 2021): 298–303. http://dx.doi.org/10.4028/www.scientific.net/kem.884.298.

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The most often prescribed antibiotics by dentists to patients is Amoxicillin. It is usually in the form of capsules and tablets which are hard to swallow, especially for geriatric and pediatric patients. Orally disintegrating tablet (ODT) with the capability to disintegrate inside oral cavity without the need of water required disintegrant agent in its formulation. In this study, chitosan as the product of deacetylation of chitin which originated from exoskeleton of crustacean shells was considered as suitable disintegrant because its swelling characteristic. The aim of this research was to st

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Ch., Taraka Ramarao* K. Reshma. "FORMULATION AND DEVELOPMENT OF TELMISARTAN TABLETS EMPLOYING FACTORIAL DESIGNS AND STABILITY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2029–35. https://doi.org/10.5281/zenodo.834606.

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The individual main effect and combined effect of commonly used β Cyclodextrin, Binders, disintegrants on the dissolution rate of telmisartan tablets were studied in 23 factorial designs employing selected combinations of 3 factors (β Cyclodextrin, Binders, disintegrants) of eight formulations of telmisartan tablets were prepared and evaluated All the telmisartan tablets were prepared good quality with regard to drug content, hardness, friability and disintegration time to fulfill official (IP) specifications of uncoated tablets. Many variations were observed in all the dissolution parameters

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Yash, Paul, Tyagi Sarvan, and Singh Bhupinder. "Formulation and Evaluation of Oral Dispersible Tablets of Zidovudine with different Superdisintegrants." International Journal of Current Pharmaceutical Review and Research 2, no. 2 (2011): 82–91. https://doi.org/10.5281/zenodo.12698580.

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Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate ordispersed in mouth without the need of water. In the present investigation eight ODTformulations of zidovudine, an antiretroviral drug, were prepared using differentsuperdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) andsodium starch glycollate by direct compression method. The effects of disintegrants indifferent concentration on the release profile of zidovudine ODTs were studied. DevelopedODTs were studied for their physicochemical properties and in vitro drug release pro

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Amruta, Pol*1 Rachana Sarawade2. "Development And Evaluation Of Sublingual Tablets Of Levodopa." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 125–40. https://doi.org/10.5281/zenodo.11109715.

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The objective of the development of this formulation was to develop a suitable drug delivery system that would bypass the hepatic metabolism and increase the bioavailability of Levodopa. Even though Levodopa exhibits low oral bioavailability it is the widely used drug for Parkinson’s disease treatment. By preparing the sublingual tablets that dissolve and disintegrate in the oral cavity, this method may overcome the limitations of low oral bioavailability and poor brain uptake of levodopa. Levodopa Sublingual tablets were prepared by direct compression method using different types of sup

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Kute, S. Shivaji*1 Sonwane Sonali S*2 Jadhav Vaibhav A2. "Super Disintegrants: An Overview." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 77–89. https://doi.org/10.5281/zenodo.10464297.

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Disintegrants play a crucial role as excipients in solid oral formulations. In immediate release and oral dispersible tablet formulations, super disintegrants like croscarmellose sodium, sodium starch glycolate, crospovidone, and polacrilin potassium are added in small quantities to counteract the effects of compression and binder after administration. The hygroscopic nature of these super disintegrants facilitates the penetration of water into the tablet matrix, while their cross-linkage reduces solubility in water. This article provides an overview of various factors that can influence the f

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Pagtalunan, Elizabeth A., Judson Lowie T. Ramos, and Gerard Q. De Guzman. "Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form." Journal of Pharmacy & Pharmacognosy Research 10, no. 4 (2022): 701–16. http://dx.doi.org/10.56499/jppres22.1377_10.4.701.

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Context: The modification of starch from the grains of NSICRc222 rice variety may provide a new material with enhanced disintegrating functionality in compressed solid dosage forms. Aims: To synthesize hydroxypropylated crosslinked rice starch that may possess characteristics of a good disintegrant. Methods: Starch was isolated by the wet milling method. The crosslinking was performed using trisodium trimetaphosphate as crosslinking agent, and successively hydroxypropylated by using phosphorous oxychloride. The evidences of chemical modifications were determined by FTIR, TGA, and DSC. The appl

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Sallam, E., H. Ibrahim, R. Abu Dahab, M. Shubair, and Enam Khalil. "Evaluation of Fast Disintegrants in Terfenadine Tablets Containing a Gas-Evolving Disintegrant." Drug Development and Industrial Pharmacy 24, no. 6 (1998): 501–7. http://dx.doi.org/10.3109/03639049809085650.

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Gurram, Syam Sundar, Nagaveni P, and Sreevalli Arigela. "Formulation and evaluation of nifedipine fast dissolving tablets." Future Journal of Pharmaceuticals and Health Sciences 4, no. 2 (2024): 32–38. http://dx.doi.org/10.26452/fjphs.v4i2.599.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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Gurram, Syam Sundar. "Formulation and evaluation of nifedipine fast dissolving tablets." Formulation and evaluation of nifedipine fast dissolving tablets 4, no. 2 (2025): 32–38. https://doi.org/10.5281/zenodo.14651206.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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Sahoo, Suvendu, and Samyuktha Metta. "An Exploration of The Potential of Natural Super Disintegrating Agents in Pharmaceutical Formulations: A Review." Journal of Pharmacological and Pharmaceutical Research 1, no. 1 (2024): 21. http://dx.doi.org/10.5455/jppr.20240107023841.

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This review delves into the use of natural super disintegrating agents in pharmaceutical drug formulations. Disintegrants are incorporated into these formulations to aid in breaking down tablets and capsules, promoting rapid dissolution by facilitating their dispersion into smaller particles. Super disintegrants, distinguished by their notable swelling capacity, play a pivotal role in expediting drug disintegration within the gastrointestinal tract. The selection of an appropriate super disintegrant hinges on several factors, including chemical compatibility, swelling potential, disintegration

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Pratama, Adam Ferdian Sigit, Setia Budi, and Melviani Melviani. "Formulation and Evaluation of Chitosan as Disintegrant for Fast Disintegrating Tablet with Fennel Seed Extract (Foeniculum vulgare)." Jurnal Ilmu Farmasi dan Farmasi Klinik 20, no. 1 (2023): 28. http://dx.doi.org/10.31942/jiffk.v20i1.7272.

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Kitosan merupakan polimer yang berasal dari cangkang hewan laut yang berpotensi digunakan sebagai disintegran. Kitosan diformulasikan dengan ekstrak biji adas menjadi sediaan Fast Disintegrating Tablet (FDT) ini untuk meningkatkan efektifitas terapi pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh kitosan sebagai disintegran pada sifat fisik FDT Ekstrak Biji Adas. Metode penelitian menggunakan metode quasi experimental dengan rancangan one-group post-test only. Dibuat 4 formula FDT dengan variasi jumlah kitosan yaitu 6 (F1), 12 (F2), 18 (F3) dan 24 (F4). Tablet dievaluasi secara

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Okafo, Sinodukoo Eziuzo, Emmanuel Agbamu, Ogheneyerhovwome Naomi Bazunu, and Ojogbane Joel Onoja. "Evaluation of the Binding Property of Irvingia Gabonesis Gum in Paracetamol Tablet Formulations Produced using Two Different Disintegrants." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND BIO-MEDICAL SCIENCE 03, no. 02 (2023): 38–44. https://doi.org/10.5281/zenodo.7599070.

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Paracetamol is mainly used as analgesic and antipyretic drug. This study was conducted to evaluate the binding property of Irvingia gabonensis gum (IGG) in paracetamol tablet formulations in the presence of either maize starch or microcrystalline cellulose as disintegrant. IGG was isolated by acetone precipitation of the filtrate from the maceration of the powdered seeds of Irvingia gabonensis (Irvingiaceae) in distilled water for 24 h. Paracetamol granules were prepared using the wet granulation method. They were produced by using various concentration of IGG as binder, maize starch or microc

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Nwachukwu, Nkemakolam, and Edwin Aboje Ubieko. "Disintegrant Properties of Native Starches obtained from Cassava, Sweet Potato and Corn in Ibuprofen Tablet Formulations." Journal of Drug Delivery and Therapeutics 10, no. 5 (2020): 264–73. http://dx.doi.org/10.22270/jddt.v10i5.4324.

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This study is aimed at evaluating the disintegrant properties of starches obtained from cassava (Manihot esculenta), sweet potato (Ipomoea batatas) and yellow corn (Zea mays). Matured tubers of cassava and potato were peeled, cut into smaller pieces, wet milled and their slurries washed severally with distilled water to obtain cassava and potato starches respectively. Matured seeds of yellow corn were steeped in distilled water for 24 h, wet milled and washed to separate the starch from the cellulose. The starches were dried at 50 ˚C after which they were characterized using standard methods.

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Nor Aida, Nafach Olya Warasky, Laila manada, Annur tasya alfiati, and Sofi agustia putri. "Formulasi Dan Evaluasi Sediaan Tablet Ibuprofen Menggunakan Berbagai Bahan Pengikat Dalam Metode Granulasi Basah." Jurnal Sains Farmasi Dan Kesehatan 2, no. 2 (2024): 99–103. https://doi.org/10.62379/jfkes.v2i2.1787.

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The aim of this research is to conduct a study on the Formulation and Evaluation of Ibuprofen Tablet Preparations Using Various Binder Materials in the Wet Granulation Method. The method used in this research is a systematic literature review. The results of this study indicate that research on ibuprofen tablet formulations shows that the physical quality of tablets is greatly influenced by the selection of binders, disintegrants, lubricants, and other excipients. The appropriate binder ensures that the tablet has the correct hardness and can disintegrate properly, allowing the active ingredie

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Yeo, Sooho, Jieun An, Changhee Park, Dohyun Kim, and Jaehwi Lee. "Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution." Pharmaceutics 12, no. 5 (2020): 407. http://dx.doi.org/10.3390/pharmaceutics12050407.

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This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When fabricating the PC-based solid dispersion, we employed mesoporous microparticles, as an adsorbent, and disintegrants to improve the sticky nature of PC and dissolution of aprepitant, respectively. The solid dispersions were prepared by a solvent evaporation technique and characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry, and X-ray powder diffraction. The FTIR results s

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Katewongsa, Prachya, and Thawatchai Phaechamud. "Influence of Disintegrant on Properties of Fast Disintegrating Tablet Containing Xylitol." Advanced Materials Research 581-582 (October 2012): 1141–44. http://dx.doi.org/10.4028/www.scientific.net/amr.581-582.1141.

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Disintegrants had influence on disintegration time and dissolution for fast disintegrating tablet (FDTs). Therefore, the purpose of this study was to evaluate the effect of disintegrant type on the characteristics of FDTs. In this research, the tablets were fabricated by direct compression with the compression force of 1.5 tons and using the different disintegrants components (chitin, chitosan, xylitol, microcrystalline celluloses, white bentonite and magnabite F). The physical properties of these tablets were determined. The xylitol tablets were rapidly disintegrated within 7+1 s, whereas tha

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Hemant Agrawal. "To prepare and evaluate orodispersible tablet of anti-inflammatory drug." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 165–73. http://dx.doi.org/10.30574/wjbphs.2022.12.1.0161.

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Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. Orodispersible tablets are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orodispersible tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes the various formulation aspects, dis

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Hemant, Agrawal. "To prepare and evaluate orodispersible tablet of anti-inflammatory drug." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 165–73. https://doi.org/10.5281/zenodo.7602741.

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Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. Orodispersible tablets are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orodispersible tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes the various formulation aspects, dis

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Amber, Zunaira Imtiaz, Amina Kanwal, Iqra Akram, and Kanwal Latif. "Formulation of extended release orphenadrine citrate tablets to treat muscle spasm and pain." Journal of Contemporary Pharmacy 4, no. 2 (2021): 30–33. http://dx.doi.org/10.56770/jcp2020421.

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Objective: Orphenadrine is an anticholinergic, antimuscarinic, centrally acting skeletal muscle relaxant. It presentsin the form of citrate and HCl salts which are used in treatment of the symptoms of mild Parkinson's disease andalso it is used as adjuvant with other drugs in the therapy. Method: Many trials were made to formulate orphenadrine citrate as tablet using wet granulation or direct compression technique in order to get a satisfactoryformula through studying the effect of various factors such as binders, diluents and disintegrants types. The bestformula was obtained by using poly vin

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Mehta, Dharmik M., P. K. Shelat, P. B. Parejiya, A. J. Patel, and B. Barot. "Investigations of Plantago ovata husk Powder as a Disintegrating Agent for Development of Famotidine Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 2 (2011): 1412–17. http://dx.doi.org/10.37285/ijpsn.2011.4.2.7.

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The main objective of this study is to explore development of pharmaceutical excipients from the husk obtained from the seeds of Plantago ovata. Husk shows very good swelling property in water due to the major part of mucilage in it. Since swelling is one of the mechanisms of action of some tablet disintegrants, it is thought that the husk powder of Plantago ovata would be able to act as a tablet disintegrant. The powder obtained from the Plantago ovata husk was characterized for micromeritical properties, swelling capacity, hydration capacity, LOD, pH, particle size, foreign particles, ash va

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Aakanksha, Pagar *. Jayshree Bhadane. "Development and Assessment of Naturally Derived Tamarind Kernel Powder as Disintegrant in Beta-Blocker Atenolol Tablet." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2133–43. https://doi.org/10.5281/zenodo.15077194.

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One common cardiovascular condition that needs to be effectively managed is hypertension. A beta-blocker called atenolol is frequently used to treat hypertension. Using tamarind seed kernel powder (TSKP) as a natural disintegrant, the study sought to create and assess atenolol tablets. TSKP was used in the formulation of the tablets, and their physical properties, dissolves profile, and disintegration time were assessed. The tablets quick and total dissolving, as demonstrated by the results, suggested that TSKP might be used as a natural disintegrant. By demonstrating the feasibility of using

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Qureshi, Muhammad Saquib, Farya Zafar, Huma Ali, et al. "SUPERDISINTEGRANT ON DISINTEGRANT AND DISSOLUTION." PROFESSIONAL MEDICAL JOURNAL 23, no. 10 (2016): 1167–70. http://dx.doi.org/10.17957/tpmj/16.3413.

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Qureshi, Muhammad Saquib, Farya Zafar, Huma Ali, et al. "SUPERDISINTEGRANT ON DISINTEGRANT AND DISSOLUTION." Professional Medical Journal 23, no. 10 (2016): 1167–70. http://dx.doi.org/10.29309/tpmj/2016.23.10.1716.

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In tablet formulation superdisintegrants are added to accelerate the rate of tabletdeaggregation and thus enhancing the rate of tablet dissolution. In this review article we gatherthe information related to the superdisintegrants, their mechanism of actions and their impacton disintegration and dissolution processes. The easiest way to achieve quick release is to usea superdisintegrants with appropriate concentrations of excipients. Different superdisintegrantsare usually added to facilitate the tablet disintegration, thus increasing the rate of tabletdissolution.

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Desai, Parind Mahendrakumar, Celine Valeria Liew, and Paul Wan Sia Heng. "Understanding Disintegrant Action by Visualization." Journal of Pharmaceutical Sciences 101, no. 6 (2012): 2155–64. http://dx.doi.org/10.1002/jps.23119.

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Chaheen, Mohammad, Ian Soulairol, Bernard Bataille, Ahmad Yassine, Emmanuel Belamie, and Tahmer Sharkawi. "Chitin’s Functionality as a Novel Disintegrant: Benchmarking Against Commonly Used Disintegrants in Different Physicochemical Environments." Journal of Pharmaceutical Sciences 106, no. 7 (2017): 1839–48. http://dx.doi.org/10.1016/j.xphs.2017.03.037.

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Chansatidkosol, Siraprapa, Praneet Opanasopit, and Prasert Akkaramongkolporn. "Tablet Disintegrant Derived from Crosslinked Methacrylic Acid and Divinylbenzene Copolymers." Advanced Materials Research 1060 (December 2014): 168–71. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.168.

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Methacrylic acid copolymers crosslinked with 0.25-16 % divinylbenzene were synthesized by free radical polymerization using benzoyl peroxide as an initiator. The products were washed, dried and passed through a 80-mesh sieve prior to determining their infrared spectra, swelling capacity in water and disintegrant efficacy for microcrystalline cellulose (MCC) placebo tablet. The crosslinked methacrylic acid and divinylbenzene copolymers were successfully prepared as indicated by IR spectra, yielding around 50-80 %. The sieved particles of copolymers were white to faint yellow. In contact with wa

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Prastika, Delia Ayu, Endang Sri Rejeki, and Widodo Priyanto. "Formulasi Orally Disintegrating Tablet (ODT) Furosemide Menggunakan Fast Disintegrant Crospovidone dan Croscarmellose Sodium dengan Metode Kempa Langsung." Jurnal Farmasi & Sains Indonesia 7, no. 1 (2024): 17–27. http://dx.doi.org/10.52216/jfsi.vol7no1p17-27.

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Orally Disintegrating Tablet (ODT) merupakan tablet yang akan hancur atau terurai dalam waktu kurang dari satu menit. Furosemid adalah diuretik kuat (loop diuretik) yang digunakan dalam pengobatan edematous yang berhubungan dengan hipertensi, jantung kongestif, gagal jantung, sirosis hati dan penyakit ginjal. Crospovidon merupakan fast disintegrant yang sangat berpori sehingga mampu mempercepat waktu hancur tablet. Croscarmellose sodium mampu menyerap air dan membengkak dengan cepat sehingga mempercepat hancurnya tablet Tujuan penelitian ini adalah mengetahui pengaruh fast dis integrant crospo

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Karandule, Akshay, Komal Madake, Rajeshwari Khairnar, and Rupali Tasgaonkar. "Tablet Binders." International Journal for Research in Applied Science and Engineering Technology 11, no. 1 (2023): 675–81. http://dx.doi.org/10.22214/ijraset.2023.48663.

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Abstract: The tablet formulation contains binders that increase the interparticulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay table

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Rajeshwari Gokul Khairnar, Ashwini Ramdas Darade, and Rupali Rajesh Tasgaonkar. "A review on tablet binders as a pharmaceutical excipient." World Journal of Biology Pharmacy and Health Sciences 17, no. 3 (2024): 295–302. http://dx.doi.org/10.30574/wjbphs.2024.17.3.0142.

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The tablet formulation contains binders that increase the inter-particulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay tablet disinte

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Rajeshwari, Gokul Khairnar, Ramdas Darade Ashwini, and Rajesh Tasgaonkar Rupali. "A review on tablet binders as a pharmaceutical excipient." World Journal of Biology Pharmacy and Health Sciences 17, no. 3 (2024): 295–302. https://doi.org/10.5281/zenodo.11365349.

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The tablet formulation contains binders that increase the inter-particulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay tablet disinte

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Gupta, Vandana, and Ashish Manigauha. "Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation." Journal of Drug Delivery and Therapeutics 11, no. 2 (2021): 42–50. http://dx.doi.org/10.22270/jddt.v11i2.4586.

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The purpose of present exploration was to modify kappa (k)-Carrageenan, by crosslinking, and assessed it as a tablet disintegrant to strengthen the solubility of the drug (aceclofenac) in tablet formulation. Modified k-Carrageenan was synthesized by reacting it with epichlorhydrin at heterogenous conditions. The swelling action of the product was investigated in order to optimize reaction circumstances for chemical cross-linking. Best modified k-Carrageenan procured by optimizing the reaction conditions and it was characterized for swelling index, particle size distribution, solubility, viscos

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Rupali, Patel, Upadhyay Nikita, Sonartiya Sunita, Jain Sourabh, and Dubey P.K. "Formulation and Evaluation of Gastro Retentive Drug Delivery System of Domperidone Mouth Dissolving Tablet by using Super Disintegrating Agents." International Journal of Pharmaceutical Sciences and Medicine 8, no. 3 (2023): 42–66. http://dx.doi.org/10.47760/ijpsm.2023.v08i03.004.

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Direct compression method can be considered as an important method for the formulation of fast dissolving tablets of Domperidone compare to wet granulation method. The rank order for the best 3 formulations is F2>F1. Formulation F2 having DCP as the super disintegrant is the best formulation of all. Higher the concentration of the lubricating agent (Magnesium Stearate or Talc), higher will be the disintegration time. Formulation having the better Super disintegrants (Ac-Di-Sol) will have better in vitro disintegration time and dissolution along with lesser friability and weight variation. T

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