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Journal articles on the topic 'Disintegrating time'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Rakesh, Pahwa* Shwetakshi Sharma Abhinav Singh Rana Anshul Garg and Inderbir Singh. "EMERGENCE OF NATURAL SUPERDISINTEGRANTS IN THE DEVELOPMENT OF ORALLY DISINTEGRATING TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 03, no. 08 (2016): 777–87. https://doi.org/10.5281/zenodo.153851.

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Orally disintegrating tablets have carved a significant role amongst the oral drug delivery systems owing to their enhanced patient compliance especially in the geriatrics and pediatrics. These tablets offer numerous substantial advantages over conventional dosage forms because of improved efficacy, bioavailability and rapid onset of action. Use of natural superdisintegrants in the development of orally disintegrating tablets has numerous benefits such as chemically inert, non-toxic, less expensive, biodegradable and widely available. The present manuscript is an earnest attempt to illustrate

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Chue, Pierre, Barry Jones, Cindy C. Taylor, and Ruth Dickson. "Dissolution Profile, Tolerability, and Acceptability of the Orally Disintegrating Olanzapine Tablet in Patients with Schizophrenia." Canadian Journal of Psychiatry 47, no. 8 (2002): 771–74. http://dx.doi.org/10.1177/070674370204700809.

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Objectives: This pilot study investigates the dissolution profile, tolerability, and acceptability of an orally disintegrating olanzapine tablet in patients with schizophrenia. Method: Eleven patients with schizophrenia stabilized on oral olanzapine (mean dosage 12.7 mg daily [SD5.2]) were given an orally disintegrating olanzapine tablet, rather than their usual tablet, daily for 7 days. At each visit, visual assessments were made for elapsed time to initial disintegration (every 15 seconds) and complete disintegration (every 1 minute). At the end of the study, patients completed a drug-accept

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3

Arooj Khalid, Roma Qayyum, Minahil Athar, et al. "Formulation and evaluation of fast disintegrating tablet of glimepiride." Journal of Contemporary Pharmacy 2, no. 1 (2018): 12–17. http://dx.doi.org/10.56770/jcp201803.

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Glimepiride is the third generation sulphonylurea agent, used for the treatment of type II diabetes mellitus. Glimepiride is given once daily in doses from 1-4 mg. The objective of the present study was to formulate and evaluate the fast disintegrating tablets of Glimepiride. Method: The fast dissolving tablets of glimepiride were prepared by direct compression method by using different disintegrating agents. The drug and the excipients were evaluated for angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio for the determination of flow property of the powder. The fo

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Gurram, Syam Sundar, Nagaveni P, and Sreevalli Arigela. "Formulation and evaluation of nifedipine fast dissolving tablets." Future Journal of Pharmaceuticals and Health Sciences 4, no. 2 (2024): 32–38. http://dx.doi.org/10.26452/fjphs.v4i2.599.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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Gurram, Syam Sundar. "Formulation and evaluation of nifedipine fast dissolving tablets." Formulation and evaluation of nifedipine fast dissolving tablets 4, no. 2 (2025): 32–38. https://doi.org/10.5281/zenodo.14651206.

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The current study aims to formulate and evaluate the fast-dissolving tablet. The optimal concentration of Guar gum super disintegrate was found to be 20 mg, with a disintegration time of 27 seconds. This study assessed the disintegration time of tablets containing natural super disintegrant for the Disintegration test at various weight concentrations (6,8,10,12,14,16,18, and 20 mg). As a result, the Nifedipine fast dissolving tablets with Guar gum super disintegrant provide a quick therapeutic effect, a high dissolve rate, and a shorter disintegration time. In this study, the use of a natural

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6

Nandhini M, Voleti Vijaya Kumar, Suganya T, et al. "Formulation, development and evaluation of fast disintegrating tablet of dapsone by using natural super disintegrates." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 3 (2024): 239–44. http://dx.doi.org/10.18231/j.ijpca.2024.034.

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The needof the fast-disintegrating tablets ever increasing day by day during the last decade. In this current research study, the effect of the natural super disintegrating agents in the Dapsone fast disintegrating tablets was compared. The natural super disintegrating agents were characterized for different physico chemical methods like Loss on drying, moisture content and Ash values.Dapsone was selected as a model drug, where the dapsone has low bioavailability due to this reason, dapsone solid dispersions were developed and the same was used to formulate the tablets. The formation of the so

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RAHMAWATI, TIAS EKA. "Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method." Media Farmasi Indonesia 19, no. 2 (2024): 130–36. http://dx.doi.org/10.53359/mfi.v19i2.278.

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Red ginger (Zingiber officinale Roxb) is one of the medicinal plants that is effective as a medicine for nausea and vomiting. One of the techniques for developing traditional medicinal products is to make fast disintegrating tablets (FDT). This research aims to compare the effect of these various disintegrating materials on the physical properties of FDT. FDT red ginger extract is made using the direct compression method. The tablets obtained were physically evaluated including weight uniformity, hardness, friability, and disintegration time. The statistical results using the one-way ANOVA tes

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A., Deevan Paul* P. Nagaraj E. Reshma T. Mahesh Y. Divyasree. "CHALLENGES IN NANOTECHNOLOGY DRUG DELIVERY SYSTEMS - STATE OF ART TECHNOLOGIES." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1550–58. https://doi.org/10.5281/zenodo.816203.

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The potential challenges to solve the poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome the dosage forms. The performance of ODTs depends on the technology used in their manufacture. The orally disintegrating property of these tablets is attributable to the quick ingress of water into the tablet matri

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Ito, Taketoshi, and Hidehiro Kamiya. "Design of Disintegration Time and Strength of Orally Disintegrating Tablets." Journal of the Society of Powder Technology, Japan 53, no. 10 (2016): 642–49. http://dx.doi.org/10.4164/sptj.53.642.

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10

Kumar, Y. Shravan, Karnakar M, Harika S, and Mounika M. "Formulation and Evaluation of Salbutamol Sulphate Taste Masked Oral Disintegrating Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 4 (2021): 5571–76. http://dx.doi.org/10.37285/ijpsn.2021.14.4.7.

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Salbutamol is a short acting, selective beta2-adrenergic receptor agonist used in the treatment of astama and COPD. The aim of this study is to formulate oral disintegrating tablets of salbutamol sulphate to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. Oral disintegrating tablets of salbutamol sulphate were designed with a view to enhance the patient compliance and provide a quick onset of action. The oral disintegrating tablets were prepared by using different synthetic polymers by direct compression method. Development of the formulation in the

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Patel, Afroza Akbar, Siraj N. Shaikh, Huzaifa Patel, Afzal Band, and Ahmed Shaoor. "Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 95–102. http://dx.doi.org/10.22270/jddt.v9i1.2176.

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The aim of this research work was to design develop & evaluate oral fast disintegrating tablets of Ranitidine HCL. The Orodispersible tablets of Ranitidine HCl were prepared by using direct Compression technique with a Synthetic Superdisintegrant such as Crosspovidone and a natural Superdisintegrant Fenugreek gum in different concentration. 32 factorial designs was applied to study the effect of independent variables, concentration of Crosspovidone & Fenugreek gum on dependent variables like Cumulative % Drug release and Disintegration time by using design expert software. Prepared ora

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Cheina Nazerina Yoshi, Luthfia Raisah Ahyati, Nur Rifa Ashya, Nurul Hasni Julianti, Yenni Hafizah, and Nor Latifah. "Analisis Pengaruh Formulasi dan Bahan Penghancur terhadap Waktu Hancur Tablet." Jurnal Ventilator 2, no. 4 (2024): 109–16. https://doi.org/10.59680/ventilator.v2i4.1533.

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Tablets are solid preparations consisting of active drug substances and fillers. The purpose of adding a crushing agent is to reduce the pressure that occurs in making tablets, especially during the tablet release process which begins with breaking it. This study aims to investigate a number of components that influence the disintegration or breaking time of tablets, such as the choice of disintegrating agent, excipient composition, and environmental conditions such as pH and temperature. The research results show that choosing the right disintegrating agent, such as starch or starch, can acce

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Jadach, Barbara, Martyna Kowalczyk, and Anna Froelich. "Assessment of Alginate Gel Films as the Orodispersible Dosage Form for Meloxicam." Gels 10, no. 6 (2024): 379. http://dx.doi.org/10.3390/gels10060379.

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The aim of this study was to obtain films based on sodium alginate (SA) for disintegration in the oral cavity. The films were prepared with a solvent-casting method, and meloxicam (MLX) as the active ingredient was suspended in a 3% sodium alginate solution. Two different solid-dosage-form additives containing different disintegrating agents, i.e., VIVAPUR 112® (MCC; JRS Pharma, Rosenberg, Germany) and Prosolve EASYtabs SP® (MIX; JRS Pharma, Rosenberg, Germany), were used, and four different combinations of drying time and temperature were tested. The influence of the used disintegrant on the

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Dubey, Abhay Kumar, and ,. Archana. "Development and In-Vitro Evaluation of Plantago ovata Based Rapid Disintegrating Tablets of Labetalol Hydrochloride." Journal of Drug Delivery and Therapeutics 12, no. 4 (2022): 36–42. http://dx.doi.org/10.22270/jddt.v12i4.5430.

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Objectives: To avoid swallowing problems of conventional tablets and improved patient compliance Plantago Ovata based Labetalol HCl Rapid disintegrating tablets have been prepared. Methods: Six different (F1 to F6) batches of Labetalol HCl Rapid disintegrating tablets were developed by ‘direct compression method’ using Plantago ovata as a natural super-disintegrating agent. The formulated RDT were tested for angle of repose’, densities like tapped and bulk density, Hausner’s ratio, Carr’s index like pre-compression parameters and for thickness, weight variation or weight uniformity, tablet har

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Dang, Yen N. T., Phuong H. L. Tran, and Thao T. D. Tran. "Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets." Recent Patents on Drug Delivery & Formulation 14, no. 1 (2020): 40–47. http://dx.doi.org/10.2174/1872211313666191029144038.

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Background: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. Objective: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS), in Orally Disintegrating Tablets (ODTs). Methods: The OGS was investigated with four different modification processes including only milling, swelling, swelling/milling, and swelling/milling/incubation. The ODTs containing the modified OGS as a disintegrant were prepared by the wet granulation method. Furthermore, an evaluation to assess parameters of tabl

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16

Chinnala, Krishna Mohan, and Sirish Vodithala. "FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF CINITAPRIDE HYDROGEN TARTARATE BY USING DIRECT COMPRESSION TECHNIQUE." International Journal of Current Pharmaceutical Research 9, no. 6 (2017): 98. http://dx.doi.org/10.22159/ijcpr.2017v9i6.23659.

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Objective: In the present study, efforts were taken to develop fast disintegrating tablets of Cinitapride hydrogen tartrate, is a gastro-prokinetic agent and antiulcer agent with an objective to achieve rapid disintegration, and further improving the bioavailability of the drug. Also, to resolve the swallowing problems (Dysphasia) in pediatric, geriatric patients by rapid disintegration in saliva and improve the patient compliance.Methods: Fast disintegrating tablets were prepared by direct compression method using superdisintegrants like crospovidone (CP), croscarmellose sodium (CCS), sodium

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17

Khatal, Hrishikesh K., Smita P. Borkar, Prakash D. Jadhav, and Vishal D. Yadav. "Formulation and Evaluation of Fast Disintegrating Tablets Containing Sertraline Solid Dispersion Using Plantago Ovata." Asian Journal of Pharmaceutical Research and Development 10, no. 2 (2022): 23–28. http://dx.doi.org/10.22270/ajprd.v10i2.1102.

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The aim of the present research is to formulate Sertraline Hydochloride solid dispersion (SRT-SD) fast disintegrating tablets. The speed of onset of action of antidepressant drug is clinically important for several reasons. Fast disintegrating tablets of SRT-SD was formulated by using natural superdisintegrant adopting direct compression method to minimize time of onset of action and also become economic. The study describes formulation of solid dispersion of SRT using HPMC E5 as a carrier and further converting SRT-SD into fast disintegrating tablets utilizing Plantago ovata mucilage as natur

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Puri, Anchal, Dhruv Dev, D. N. Prasad, Shabnam Hira, and Rajni Sharma. "THE Modified Okra Gum with Silica: A Novel Superdisintegrant for Fast Disintegrating Tablet." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 206–11. http://dx.doi.org/10.22270/jddt.v9i3-s.3002.

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The present work on the fast disintegrating tablet of Atenolol was done to formulate a dosage form which can release the active ingredient at the faster rate. The fast disintegrating tablet was made by wet granulation method, the natural gum was used (Modified Okra Gum (Abelmoschus esculentus)). The gum in a modified form is a combination with the silica which increases the disintegration rate of the gum. The swelling index of Modified gum was found as 205. The pH of the gum was found as 6.1, in the gum no microbial growth was found during the study. In the contact with the water, due to high

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J.Nasser, Saddam, Laith H. Sameen, and Mowafaq M.Ghareeb. "Preparation and Evaluation of Oral Disintegrating Tablets of Ketoprofen by Dirct Compression." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 2 (2017): 63–68. http://dx.doi.org/10.31351/vol21iss2pp63-68.

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Ketoprofen is a non-steroidal anti-inflammatory (NSAID) drug with analgesic, anti-inflammatory, and antipyretic effects. It is widely used in the treatment of inflammation and pain associated with rheumatic disorders such as rheumatoid arthritis, osteoarthritis, and in soft tissue injury. The purpose of this study was to prepare an oral disintegrating tablets of ketoprofen by simple method. The tablets were prepared by direct compression method and different ratios of various subliming agents or superdisintegrants were incorporated. Then these tablets were evaluated for hardness, friability, w

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Anjali, T., P. SS Prasanna Kumar, N. Srinivas, and K. Shivaji. "Formulation and evaluation of aceclofenac fast disintegrating tablets using sida acuta powder." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 1 (2024): 77–84. http://dx.doi.org/10.18231/j.ijpca.2024.011.

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Aceclofenac is a NSAID with anti-inflammatory, analgesic activity. The aim is to develop the Aceclofenac tablets with sida acuta powder that exhibit rapid disintegration, dissolution and showing maximum pharmacological activity in less time. This is desirable for improving patient compliance. The present study was to formulate and evaluate the fast-disintegrating tablets of Aceclofenac using Sida acuta powder by direct compression technique with varying concentrations. Each formulation was evaluated for pre and post evaluation tests such as Flow property, Bulk density, tapped density, Weight v

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M T, Ranjitha, and C. N. Somashekhar. "PREPARATION AND EVALUATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE AS ORAL DISINTEGRATING TABLET BY DIRECT COMPRESSION METHOD." Journal of Pharmaceutical and Scientific Innovation 10, no. 4 (2021): 94–101. http://dx.doi.org/10.7897/2277-4572.104211.

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A new dosage form, Oral disintegrating tablets (ODT’s) as a replacement to conventional oral dosage forms. ODT’s are dosage forms they disintegrate in mouth offering various advantages such as better mouth feel, dose accuracy, improved stability and convenient dosing as compared to oral liquids. So, there is need to designed oral disintegrating tablet to release the medicaments with an enhanced rate. Mefenamic acid is an anti- inflammatory drug while Dicyclomine HCl is anti-cholinergic drug. The combination of Mefenamic acid & Dicyclomine HCl controls pain very effectively, also relaxes bo

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Eremin, V. A., and E. V. Blynskaya. "Modern approaches to assessing the quality of orally disintegrating tablets." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 6 (December 19, 2023): 8–17. http://dx.doi.org/10.33920/med-13-2306-01.

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Orally disintegrating tablets (ODTs) are the preferred and accepted solid dosage forms by patients. These tablets disintegrate in the oral cavity within a short period, providing an advantage for individuals who have difficulty swallowing. Quality control of ODTs can be achieved through measures such as friability, porosity, hardness, wetting time, water absorption capacity, in vitro disintegration test, and dissolution test. This article summarizes the advantages and in vitro quality control tests of orally disintegrating tablets.

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Kumar, Y. Shravan, Prashanthi Patel, Sravanthi Ch, and Rashmi B. "Formulation and Evaluation of Taste Masked Oral Disintegrating Tablets of Aripiprazole." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 1 (2015): 2723–34. http://dx.doi.org/10.37285/ijpsn.2015.8.1.4.

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 Aripiprazole is an atypical antipsychotic agent used for treatment of schizophrenia, bipolar disorder and major depressive disorders. In the present work, oral disintegrating tablets of aripiprazole were developed to enhance the patient compliance and provide rapid onset of action. The efficacy of aripiprazole is mediated through a combination of partial agonist activity at dopamine D2 and serotonin 5HT-1A receptors and antagonist activity at 5HT-2A receptors. It has a bitter taste and poor-solubility in water. Thus, the main objective of the study is to formulate taste masked oral disi

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Sanskruti Vilas Pawshe and Bhavana Dnyandeo Tambe. "Development and evaluation of anti-hemorrhoid alum suppositories." International Journal of Science and Research Archive 12, no. 1 (2024): 131–41. http://dx.doi.org/10.30574/ijsra.2024.12.1.0760.

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Rectal suppositories of Alum were prepared using different bases and polymers like Shea butter, and PEG-4000 and its effect on the In-vitro release of Alum was studied. The Agar-based suppositories were non-disintegrating, and non-dissolving, whereas PEG-4000 based were disintegrating and dissolving. The Fusion Method and Trituration Method were used for the formulation of the suppositories. In-vitro tests were carried out on the formulations. All the formulated suppositories were tested for several physical parameters namely weight variation, drug content of suppositories, disintegration test

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Akanksha, Sharma, Garg Vishal, Kumar Gupta Manish, and Sharma Vijay. "A Consensus Review on Fast Disintegrating Tablets." Pharmaceutical and Chemical Journal 5, no. 1 (2018): 240–60. https://doi.org/10.5281/zenodo.13895816.

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Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researcher developed the fast disintegrating tablets with improved patient compliance and convenience. Fast disintegrating tablets are solid dosage forms which dissolve rapidly in saliva without chewing and additional water. Fast disintegrating tablets overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in pediatric and geriatric patients. Fast disintegrating tablets have received ever-incr

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Fitriana, Mia, Muhammad Habibie, Abidzar Mirza, and Rafli Al Anshari. "Formulasi Fast Disintegrating Tablet Ekstrak Etanol Avicennia marina fructus dengan Metode Granulasi Basah." Jurnal Pharmascience 9, no. 1 (2022): 89. http://dx.doi.org/10.20527/jps.v9i1.12853.

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Avicennia marina fructus mengandung kandungan senyawa berupa alkaloid, flavonoid, saponin, glikosida yang terbukti memiliki aktivitas antidiabetes. Prevalensi diabetes melitus semakin meningkat pada pasien geriatri. Pasien geriatri cenderung mengalami kesulitan menelan tablet konvensional sehingga perlu dibuat sediaan yang lebih cepat hancur seperti fast disintegrating tablet. Salah satu metode granulasi yang dapat digunakan untuk membuat fast disintegrating tablet adalah menggunakan metode granulasi basah. Penelitian ini bertujuan untuk Penelitian ini bertujuan untuk menentukan formula fast d

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Dr. Usha D S, Jadav Prakruti Kishorchandra, Dr. V. Antony Asir Daniel, et al. "Formulation And Evaluation Of Fast Disintegrating Tablets Of Herbal Powder Extracts For Headache." International Journal of Environmental Sciences 11, no. 9s (2025): 924–34. https://doi.org/10.64252/2ytpqg04.

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Oral medication administration is perhaps the most common method of the dosage form. Researchers have been encouraged by recent technological advancements to produce Fast disintegrating tablets (FDTs) to enhance patient compliance and accessibility. The study was designed to evaluate the composition and efficacy of herbal fast disintegrating tablets for headache care. Herbal powder extracts of Salix alba L (White Willow bark), Tinospora cordifolia (Guduchi), Achyranthes aspera (Latjira), Cyprus rotundus (Nagarmotha), and Withania somnifera (Ashwagandha) are produced and processed into fast dis

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Jain, P., A. Mishra, and A. Pathak. "PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD." INDIAN DRUGS 52, no. 12 (2015): 60–62. http://dx.doi.org/10.53879/id.52.12.10465.

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Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating

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Sharma, Deepak, Gurmeet Singh, Dinesh Kumar, and Mankaran Singh. "Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate, Cetirizine Hydrochloride in Combined Pharmaceutical Dosage Form: A New Era in Novel Drug Delivery for Pediatrics and Geriatrics." Journal of Drug Delivery 2015 (February 25, 2015): 1–10. http://dx.doi.org/10.1155/2015/640529.

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The objective of the present study was to prepare the fast disintegrating tablet of Salbutamol Sulphate, Cetirizine Hydrochloride in combined tablet dosage form for respiratory disorders such as bronchitis, asthma, and coughing for pediatrics and geriatrics. The tablets were prepared by direct compression technique. Superdisintegrant such as Sodium Starch Glycolate was optimized as 4% on the basis of least disintegration time. Different binders such as MCC and PVP K-30 were optimized along with optimized superdisintegrant concentration. 1% MCC was selected as optimum binder concentration on th

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Jaya, S., and V. Amala. "FORMULATION AND IN VITRO EVALUATION OF ORAL DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 49. http://dx.doi.org/10.22159/ijap.2019v11i1.28457.

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Objective: The present investigation was undertaken with an objective of formulating oral disintegrating tablets of amlodipine besylate to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy.Methods: The tablets were prepared by using direct compression method and evaluated for weight variation, hardness, friability, wetting time, disintegration time and in vitro drug release study. Prepared tablets were evaluated for compatibility by Fourier transform infrared spectroscopy.Results: Fourier transform infrared spectroscopy studies revealed th

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Que, Li, Wei Wu, Xiaofeng Cheng, and Tao Hu. "Evaluation of Disintegrating Time of Rapidly Disintegrating Tablets by a Paddle Method." Pharmaceutical Development and Technology 11, no. 3 (2006): 295–301. http://dx.doi.org/10.1080/10837450600767649.

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Choudhary, Nilesh, and Jasmine Avari. "Formulation and evaluation of taste mask pellets of granisetron hydrochloride as oro dispersible tablet." Brazilian Journal of Pharmaceutical Sciences 51, no. 3 (2015): 569–78. http://dx.doi.org/10.1590/s1984-82502015000300009.

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Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest compliance of the patients, especially the geriatrics and pediatrics. In addition, patients suffering from dysphagia, motion sickness, repeated emesis and mental disorders prefer these medications because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in these dosage forms. However, the requirements of formulating these dosage forms with m

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Alejandro, Blasco, Torrado Guillermo, and Peña M. Ángeles. "Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets." Pharmaceuticals 13, no. 5 (2020): 100. http://dx.doi.org/10.3390/ph13050100.

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This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The res

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Shaikh, Siraj Nawaj* Shaikh Heena Kausar G. J. Khan Tajammul Khan. "INSIGHT IN TO USE OF CO PROCESS EXCIPIENTS IN ORAL DISINTEGRATING TABLETS-REVIEW ARTICLE." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2622–26. https://doi.org/10.5281/zenodo.858669.

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Fast Disintegrating tablets have started gaining popularity and acceptance as new drug delivery systems, because t hey are easy to administer. Recent development in fast disintegrating technology mainly works to improve the disint egration quality of these delicate dosage forms without affecting their integrity. Oral disintegrating dosage form have facing many challenges which can be overcome by upcoming newly emerging approach of use of coprocess adujants in it. The developments or improvements in pharmaceutical process and equipments, particularly increase in production rates at low cost, le

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Singh, Sudarshan, S. S. Shyale, and P. Karade. "Formulation and Evaluation of Orally Disintegrating Tablets of Lamotrigine." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (2015): 2881–88. http://dx.doi.org/10.37285/ijpsn.2015.8.2.11.

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The aim of this study was to design orally disintegrating tablet (ODT) of Lamotrigine. It is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.46 mg/ml). Thus, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:1 molar ratios). The orally disintegrating tablet of lamotrigine was prepared by direct compression method using different concentration of superdisintegrants such as Sodium starch glycollate, croscarmell

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Aslani, Abolfazl, Alireza Ghasemi, and Shekofeh Karbasizadeh Esfahani. "Design, Formulation and Physicochemical Evaluation of Dimenhydrinate Orally Disintegrating Tablets." Galen Medical Journal 7 (May 27, 2018): e936. http://dx.doi.org/10.31661/gmj.v7i0.936.

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Background: Design, formulation and physicochemical evaluation of dimenhydrinate 25 mg oral tablets that disintegrate in oral cavity in a proper time. This product is easy to use for babies, geriatrics and people who have difficulty in swallowing. Materials and Methods: 31 formulations were designed in 3 categories via Design-Expert software version 7. Group 1 consist of super-disintegrating bases, group 2 consist of effervescent bases and group 3 consist of super-disintegrating and effervescent bases together. Proposed by Design-Expert software, the optimum formulations were selected in each

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Sharma, Deepak, Mankaran Singh, Dinesh Kumar, and Gurmeet Singh. "Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Pediatrics and Geriatrics." Journal of Pharmaceutics 2014 (February 18, 2014): 1–8. http://dx.doi.org/10.1155/2014/808167.

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Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptab

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Sharma, Deepak. "Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders." ISRN Pharmaceutics 2013 (July 15, 2013): 1–8. http://dx.doi.org/10.1155/2013/674507.

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Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of salbutamol sulphate for respiratory disorders for pediatrics. As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s acceptabil

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Bafail, Rawan SM. "Disintegration testing for orally disintegrating tablets (ODTs): An overview." Tropical Journal of Pharmaceutical Research 22, no. 11 (2024): 2399–406. http://dx.doi.org/10.4314/tjpr.v22i11.21.

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Prescribing orally disintegrating tablet (ODT) dosage form is a common practice. For several populations, including geriatrics and pediatrics, ODTs are one of the most desired dosage forms. They are solid dosage forms designed to disintegrate or dissolve very quickly in contact with saliva as soon as they are placed in oral cavity of a patient. According to United States Pharmacopeia (USP), every dosage form has to pass some quality control tests to ensure uniformity and performance of this dosage form. For ODTs, disintegration test is fundamental to ascertain time required for tablets to brea

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Kundawala, Aliasgar, Pratik Patel, Khushbu Chauhan, Anjali Desai, and Dhwani Kapadia. "Formulation and Optimization of Orodispersible Tablet of Loratadine Using Box Behnken Design." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 86–94. http://dx.doi.org/10.22270/jddt.v9i4-a.3402.

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In present study Orodispersible tablets (ORDT) of Loratadine were prepared and optimized. Solid dispersion of Loratadine- β cyclodextrin complex were prepared and used in preparation of Orodispersible tablets. Various super-disintegrating agent like Cross carmellose sodium, Cross povidone and Kyron T-314 were employed for faster disintegrating effect. The 24 factorial and Box-Behnken design were utilized to optimize the tablet formulation. The Orodispersible tablet of Loratadine was optimized by Box Behnken Design, where concentrations Kyron T-314, CRP and Pearlitol SD200 were employed and its

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Rédai, Emőke Margit, Emese Sipos, Robert Alexandru Vlad, Paula Antonoaea, Nicoleta Todoran, and Adriana Ciurba. "Development of Co-Amorphous Loratadine–Citric Acid Orodispersible Drug Formulations." Processes 10, no. 12 (2022): 2722. http://dx.doi.org/10.3390/pr10122722.

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This study aimed at the preparation and characterization of co-amorphous loratadine–citric acid orally disintegrating dosage forms (ODx). A co-amorphous loratadine–citric acid was prepared by solvent evaporation method in three different molecular ratios. DSC, FTIR, and dissolution studies have been conducted for the binary system. The co-amorphous system was used to obtain oral lyophilizates and orally disintegrating tablets by direct compression. Diameter, thickness, hardness, disintegration time, uniformity of mass, and dissolution was determined for the dosage forms. DSC curves showed a la

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Mane, Swapna, Ritesh Bathe, and Sandhyarani Awatade. "Formulation and Evaluation of Fast Disintegrating Tablets of Atenolol Using Natural and Synthetic Superdisintegrants." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 150–58. http://dx.doi.org/10.22270/jddt.v9i2-s.2476.

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Oral disintegrating tablet (ODT) is defined as “A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. The aim of the present research is to formulate Atenolol fast disintegrating tablets. Atenolol is β1- cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension, angina pectoris, arrhythmias and myocardial infarction. It works by slowing down the heart and reducing the work load of the heart. The conventional tablets of atenolol are reported to exhibit f

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Sarfaraz, Mohammed, and Surendra Kumar Sharma. "FORMULATION AND EVALUATION OF FLURBIPROFEN FAST DISINTEGRATING TABLETS USING NATURAL SUPERDISINTEGRANTS." Asian Journal of Pharmaceutical and Clinical Research 9, no. 6 (2016): 247. http://dx.doi.org/10.22159/ajpcr.2016.v9i6.14303.

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ABSTRACTObjective: The main objective of this research was to formulate Fast disintegrating tablets of Flurbiprofen incorporating superdisintegrants, isolated from natural sources like Plantago ovata (PO) seeds, Lepidium sativum (LS) seeds and agar-agar.Methods: Superdisintegrants were isolated from their natural sources using reported methods. Swelling index and hydration capacity was determined for the natural superdisintegrants to know their disintegration capacity. The tablet formulations were designed using isolated natural superdisintegrants. The powder blends were evaluated for pre-comp

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Wang, Rui, Mingjie Zheng, Bin Ao, Hongqing Liu, and Peifeng Cheng. "Disintegration Characteristics Investigation of Carbonaceous Shale in High-Latitude Cold Regions." Buildings 13, no. 2 (2023): 466. http://dx.doi.org/10.3390/buildings13020466.

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To investigate the disintegration and microstructure characteristics of carbonaceous shale in high-latitude cold regions, indoor, outdoor, initial particle size, and freeze–thaw disintegration experiments were conducted concerning dry–wet cycles. Two tests were performed: sieving and microscopic scanning electron analysis. The carbonaceous shale disintegration, particle size variation rule, disintegration resistance, and fractal characteristics were studied. The microstructure variations of carbonaceous rock before and after water immersion were compared, and the microscopic mechanism of calvi

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Kanke, Pralhad K., Pankaj Sawant, Ajit Jadhav, and Md Rageeb Md Usman. "A REVIEW ON DISINTEGRATION CONTROL MATRIX TABLETS." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 19–22. http://dx.doi.org/10.22270/jddt.v8i5.1852.

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A number of sustained release formulations are available in the market which successfully sustained the drug release over a prolonged period of time by different mechanisms. The new approach for sustaining the drug release is disintegration control matrix tablet which sustained the drug release up to 24hrs by controlling the disintegration rate of tablet. Disintegration control matrix tablet (DCMT) mainly forms the granules containing drug and disintegrating agent such as low substituted hydroxyl propyl cellulose by various methods such as solid dispersion technique. The sustained release of d

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Budipratiwi Wisudyaningsih, Lusia Oktora Kumala Sari, and Tiara Puspita Arisanti. "OPTIMASI SODIUM STARCH GLYCOLATE DAN POLYVINYLPYRROLIDONE K-30 DALAM SEDIAAN ORALLY DISINTEGRATING TABLET SALBUTAMOL SULFAT." Jurnal Kesehatan Islam : Islamic Health Journal 12, no. 2 (2023): 19–27. http://dx.doi.org/10.33474/jki.v12i2.20838.

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ABSTRACT Difficulty in swallowing drug and slow onset of action of drug are common problems of conventional tablet. Orally disintegrating tablet (ODT) is an innovative dosage form to overcome the problem of swallowing drug and provide quick onset of action of drug because it can disintegrates quickly when contact with saliva in less than 3 minutes. This study formulate and evaluate ODT containing salbutamol sulphate to relieve the respiratory disorders immediately. Materials that affect the disintegration time of ODT are superdisintegrants and binders. Sodium Starch Glycolate (SSG) is a superd

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Amrutkar, Samiksha S., Shivam K. Navale, Deepak S. Bhambere, Pooja Birari, Shweta Shevatkar та Sapana P. Ahirrao. "Development and Assessment of Loratadine Fast-Disintegrating Tablets via β-Cyclodextrin Complexation with Superdisintegrants". Biosciences Biotechnology Research Asia 21, № 3 (2024): 1211–26. http://dx.doi.org/10.13005/bbra/3298.

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ABSTRACT: This study aimed to enhance the solubility and consequent bioavailability of Loratadine, a widely used medication for seasonal allergic rhinitis and chronic idiopathic urticaria. The approach involved complexation with β-cyclodextrin to improve solubility and the formulation of fast-disintegrating tablets via the sublimation method. Crosspovidone acted as a superdisintegrant, while camphor served as a sublimating agent. Methodology: Pre-compression parameters were assessed to ensure adequate flow properties, while post-compression parameters were evaluated against IP acceptable limit

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Dhruv, Dev, Rai Diksha, and Prasad D. N. "CALCIUM SALT OF CARBOXYMETHYLED AEGLE MARMELOS (BAEL FRUIT) GUM: A NOVEL SUPERDISINTEGRANT FOR FAST DISINTEGRATING TABLETS." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (2018): 73–80. http://dx.doi.org/10.22270/ajprd.v6i4.384.

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The present study was carried out for the preparation of modified Aegle marmelos gum as natural superdisintegrant and assessed it on various parameters for preparing fast dissolving dosage form. The extracted gum from Aegle marmelos fruit is chemically modified by carrying out its carboxymethylation and further complexed with Calcium chloride. Therefore, the natural Superdisintegrant prepared from Aegle marmelos gum followed swelling and wetting mechanism for disintegration of the dosage form. The change in the functional groups of the extracted gum, carboxymethyled gum and the calcium complex

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Nestorovska-Gjosevska, Biljana Nestorovska-Gjosevska, Marija Glavas-Dodov, and Katerina Goracinova. "Orally disintegrating tablet: formulation design and optimisation using Response Surface Methodology." Macedonian Pharmaceutical Bulletin 51 (2005): 15–22. http://dx.doi.org/10.33320/maced.pharm.bull.2005.51.003.

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The objective of this study was to develop diazepam orally disintegrating tablets and to optimize tablets characteristics using response surface methodology (RSM). Tablets were prepared by direct compression of mixture containing mannitol, copovidone, crosspovidone flavor and lubricant. A full factorial design for 2 factors at 3 levels each was applied to investigate the influence of 2 formulation variables on the mechanical strength/hardness, the percent of friability, disintegration time and dissolution of the poorly soluble active ingredient. The amounts of copovidone and crosspovidone were

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Oral, disintegrating film Hydroxypropyl methylcellulose Solvent casting Brivaracetam. "Formulation And Evaluation of Oral Disintegrating Film Containing Brivaracetam." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 556–65. https://doi.org/10.5281/zenodo.14106902.

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Oral disintegrating films (ODFs) are innovative drug delivery systems designed to dissolve rapidly in the oral cavity without the need for water. These films are particularly beneficial for patients who have difficulty swallowing traditional dosage forms, such as the elderly and paediatric populations. This study aims to develop ODF containing Brivaracetam were formulated using a different grade of HPMC E15 and HPMC E50 and plasticizers like polyethylene glycol and propylene glycol using solvent casting method. The formulated films were evaluated for thickness, folding endurance, weight variat

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