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Relevant bibliographies by topics / Dispersible tablets

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Academic literature on the topic 'Dispersible tablets'

Author: Grafiati

Published: 3 June 2025

Last updated: 6 July 2025

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Journal articles on the topic "Dispersible tablets"

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Nutan, Prakash Sharma, Pandey Shivam, and Sharma |. Jaya Singh Hariom. "A Review on Dispersible Tablets A Novel Drug Delivery System for Pedietrics and Geriatrics." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1188–92. https://doi.org/10.5281/zenodo.3590783.

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Novel Drug Delivery system offer great chance to invent new drug delivery system for the betterment of the life. Oral dispersible tablets are modern day technology and extensively used for those formulations which are required for pediatrics and geriatrics. Dispersible tablet disintegrates rapidly into the mouth in presence of saliva, as they don't require water for disintegration. Such rapid disintegration is helpful for the person having problem of dysphasia. Dispersible tablet requires a key ingredient called supradisintegrants for such rapid and effective disintegration. There are various methodologies used for preparing such effective dispersible tablets like - Compaction method, Freeze Drying, Molding Method, Sublimation, all such methods are effective to make dispersible tablets. There is need of evaluation of each and every tablet after manufacturing which requires evaluation parameters such as weight variation, Disintegration test, Dissolution Test, Hardness, and Thickness. This article discuss about dispersible tablets, methods of preparation for dispersible tablets, evaluation parameters and advantages and disadvantages. Nutan Prakash Sharma | Shivam Pandey | Hariom Sharma | Jaya Singh "A Review on Dispersible Tablets: A Novel Drug Delivery System for Pedietrics and Geriatrics" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25098.pdf

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Wang, Yifei, Zhisheng Wu, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, and Yanjiang Qiao. "Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI." Journal of Innovative Optical Health Sciences 09, no. 02 (2016): 1550016. http://dx.doi.org/10.1142/s1793545815500169.

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The present study aimed at investigating the relationship between tablet hardness and homogeneity of different Yinhuang dispersible tablets by near-infrared chemical imaging (NIR-CI) technology. The regularity of best hardness was founded between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets. The ingredients homogeneity of Yinhuang dispersible tablets could be spatially determined using basic analysis of correlation between analysis (BACRA) method and binary image. Then different hardnesses of Yinhuang dispersible tablets were measured. Finally, the regularity between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets was illuminated by quantifying the agglomerate of polyvinyl poly pyrrolidone (PVPP). The result demonstrated that the distribution of PVPP was unstable when the hardness was too large or too small, while the agglomerate of PVPP was smaller and more stable when the best tablet hardness was 75[Formula: see text]N. This paper provided a novel methodology for selecting the best hardness in the tabletting process of Chinese Medicine Tablet.

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Shivam, Pandey, Hariom Sharma Dr., and Singh Jaya. "Review on Novel Drug Delivery System and Antihypertensive Tablets." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1283–86. https://doi.org/10.5281/zenodo.3590981.

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Novel drug delivery system offers excellent opportunity to the inventors for developing new technologies for drug administration, dispersible tablets are come under this category as it offers various advantages over conventional tablets. Dispersible tablets offer rapid disintegration in the mouth while came in contact with saliva. It is good find and rapid solution for the problem of dysphasia among geriatrics, as they feel some problem in swallowing a tablet. This article discuss about dispersible tablets, dysphasia, advantages and disadvantages of dispersible tablets. It also discuss about hypertension and antihypertensive tablets. Shivam Pandey | Dr. Hariom Sharma | Jaya Singh "Review on Novel Drug Delivery System and Antihypertensive Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25120.pdf

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Wademan, D. T., H. R. Draper, S. E. Purchase, et al. "Acceptability of levofloxacin dispersible and non-dispersible tablet formulations in children receiving TB preventive treatment." IJTLD OPEN 1, no. 2 (2024): 69–75. http://dx.doi.org/10.5588/ijtldopen.23.0462.

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<sec><title>BACKGROUND</title>We evaluated the palatability and acceptability of a 100 mg dispersible and a non-dispersible 250 mg levofloxacin (LVX) tablet formulation in children.</sec><sec><title>METHODS</title>Perform was a randomised, open-label, cross-over trial of the relative bioavailability of LVX dispersible vs. crushed non-dispersible tablets in children aged <6 years routinely receiving TB preventive treatment. Children and caregivers completed Likert- and ranking-type measures on the acceptability of both formulations. We used summary, comparative and ranking statistics to characterise formulation acceptability.</sec><sec><title>RESULTS</title>A total of 25 children were enrolled (median age: 2.6 years, IQR 1.6–4.0). Caregivers reported frequent challenges with preventive therapy in routine care prior to study entry, including taste of tablets (n = 14, 56%), vomiting/spitting out medicines (n = 11, 44%), and children refusing medicines (n = 10, 40%). Caregivers reported that the dispersible formulation was easier for their child to take than the non-dispersible formulation (P = 0.0253). Mean ranks for caregiver’s formulation preferences (dispersible tablets: 1.48, SD ±0.71; non-dispersible tablets: 2.12, SD ±0.67; routinely available formulations: 2.40 SD ±0.82) differed significantly (Friedman’s F 11.120; P < 0.0038); post-hoc testing showed dispersible tablets were preferred over non-dispersible (P = 0.018) and routinely available LVX formulations (P < 0.001).</sec><sec><title>CONCLUSIONS</title>The dispersible LVX 100 mg tablet formulation was preferred and should be prioritised for integration into routine care.</sec>

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Jangid, Shubham, Akash Yadav, and Dinesh Kumar Jain. "DISPERSIBLE TABLET AS A FORMULATION FOR ORAL DRUG DELIVERY SYSTEM." Journal of Advanced Scientific Research 14, no. 01 (2023): 08–14. http://dx.doi.org/10.55218/jasr.202314102.

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Dispersible drug delivery methods are widely utilized nowadays to increase patient compliance and bioavailability. Overthe past years, dispersible tablets have gained a lot of attention as a preferable alternative to conventional tablets andcapsules due to increased patient compliance, improved solubility, and improved stability profiles. Dispersible tabletsmay be a better option, particularly for medications that react negatively to GI fluids, to cover up a medication's bittertaste, and for patients, who fall into the paediatric or geriatric categories, are bedridden, have recently undergonesurgery, or may have trouble swallowing conventional tablets and capsules. These tablets instantly break down in thewater to create the suspension. The key component of a dispersible tablet is the super disintegrants. When a dispersibletablet comes into touch with water, it becomes moist and swells significantly, quickly disintegrating.

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Khan, Sohail, Farya Zafar, Huma Ali, et al. "WATER DISPERSIBLE TABLETS." Professional Medical Journal 23, no. 09 (2016): 1022–25. http://dx.doi.org/10.29309/tpmj/2016.23.09.1688.

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Water dispersible tablets are considered to be an attractive alternate tothe conventional tablets. In this review we reported the information related to the desiredcharacteristic and formulation challenges of these formulations.

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Barge, Kajal, Shivali Tank, Bhagyashri Parab, Mangal Nagarsenkar, and Supriya Shidhaye. "Fexofenadine Hydrochloride Dispersible Tablets: A Taste Masking Strategy using Ion Exchange Resin." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 846–53. http://dx.doi.org/10.25258/ijddt.13.3.12.

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The pediatric population is more sensitive to allergies. Fexofenadine hydrochloride (FXD-HCL), a non-sedative antihistaminic drug, was chosen to create taste-masked patient-compliant pediatric dispersible tablets. Due to its bitter taste, fexofenadine hydrochloride is unsuitable for the formulation of dispersible tablets; therefore, Kyron T-134®, cation exchange resin was used to form a taste-masked complex with the drug to overcome its bitterness. The FXD HCL-resin complex was prepared using a kneading method and the complexation was confirmed by differential scanning calorimetry and FTIR studies. The FXD HCL-resin complex was evaluated for flow properties, degree of bitterness, assay and release study. Dispersible tablets were formulated by using a co-processed excipient, Granfiller-D211® containing croscarmellose sodium and crosspovidone, microcrystalline cellulose and mannitol. 22 factorial designs with two replicates optimized the dispersible tablets. The tablets, prepared using the direct compression technique on a single-stroke tablet compression machine, were elegant in appearance. Various pre and post-compression tests were conducted on all formulations. The tablets of hardness 3.5 kg/cm2 showed friability, disintegration time, assay within the compendial limit and showed immediate release of a drug (NLT 60% in 10 min and NLT 80% in 30 minutes) in 0.001 N HCl (pH 3). The DSC thermogram indicated partial amorphization of the FXD HCL. Dispersible tablets of fexofenadine hydrochloride and Granfiller-D®211 at 1:4 proportion was stable for one month at ambient and accelerated storage conditions.

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Schiermeier, Simone, and Peter Christian Schmidt. "Fast dispersible ibuprofen tablets." European Journal of Pharmaceutical Sciences 15, no. 3 (2002): 295–305. http://dx.doi.org/10.1016/s0928-0987(02)00011-8.

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Kumar, Voleti Vijaya, Nandhini M, Sreelekhaa T, et al. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Future Journal of Pharmaceuticals and Health Sciences 4, no. 1 (2024): 1–13. http://dx.doi.org/10.26452/fjphs.v4i1.548.

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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally liked because of their convenience, higher bioavailability, quick disintegration and breaking down of the medication. The various technologies utilized in the formulation of Orodispersible tablets (ODT) and their evaluation are the primary focus of this review.

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V, Vijaya Kumar. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants 4, no. 1 (2024): 1–13. https://doi.org/10.5281/zenodo.14649969.

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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally liked because of their convenience, higher bioavailability, quick disintegration and breaking down of the medication. The various technologies utilized in the formulation of Orodispersible tablets (ODT) and their evaluation are the primary focus of this review.

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Dissertations / Theses on the topic "Dispersible tablets"

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Strachan, Christine Elizabeth. "The formulation technology of dispersible tablets." Thesis, Liverpool John Moores University, 2000. http://researchonline.ljmu.ac.uk/5071/.

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Van, Vuuren Carin Eloïse Jansen. "Formulation and evaluation of diclofenac sodium dispersible tablets / Carin-Eloïse Jansen van Vuuren." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1053.

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Diclofenac sodium is a non-steroidal, anti-inflammatory drug used for the relief of pain and inflammation. Many patients have difficulty swallowing tablets and consequently do not take medication as prescribed. To achieve optimum benefit of a drug, it is desirable to present it in a formulation which can rapidly disperse in water. This formulation is easier to swallow, therefore enhancing patient compliance. The aim of this study was to develop a stable diclofenac sodium dispersible tablet for easier oral administration. The first step in the product development was an investigative study into the physico-chemical properties, indications, side-effects and contra-indications of diclofenac sodium. Diclofenac sodium - excipient compatibility studies were performed as part of a preformulation study. Methods of evaluation included differential scanning calorimetry (DSC) and high performance liquid chromatography (HPLC). Four dispersible tablet formulations were developed. Kollidon CL-M (crospovidone) and Disolcel (croscarmellose sodium) were used as disintegrants in concentrations of 2% and 5% of the tablet mass. Tabletting was performed using a Cadmach® (India) single-punch tabletting machine. The four formulations were put on accelerated stability according to ICH guidelines for three months at 25°C/60%RH, 30°C/65%RH and 40°C/75%RH. HPLC was used to determine the identification, chromatographic purity and concentration of diclofenac sodium. Other tests included uniformity of mass, hardness, friability, disintegration, fineness of dispersion, loss on drying and dissolution. Thermal compatibility studies revealed potential interactions between diclofenac sodium and the excipients. Since DSC results only serve as a rough indication of possible interactions, accelerated stability testing using HPLC was used as a more selective method to identify potential interactions between diclofenac sodium and excipients. The HPLC results revealed that no interactions exist between diclofenac sodium and the chosen excipients. At the end of the stability period, no change in the physical appearance of the tablets was observed, except for the samples stored at 40°C/75% RH which showed a colour change from white to a very light brown after 3 months. Uniformity of mass remained within specification and average tablet mass and diameter remained relatively constant during stability testing. There was an increase in average thickness, hardness, disintegration time and percentage loss on drying with time and increased stress conditions. This correlates with the decrease in friability observed with time. Differences in the disintegration times were noted between Kollidon CL-M® and Disolcel® formulations. The only formulation that disintegrated within 3 minutes was formulation B. Very few particles of formulation B were retained on the 710 urn sieve, indicating a homogeneous dispersion. Assay results for all four formulations were within specification throughout stability and no extra peaks ascribed to diclofenac related compound A or any other impurity were observed. After 30 minutes, more than 85% of diclofenac sodium in formulations A, B and D was dissolved. The diclofenac sodium in formulation C did not dissolve well. This correlates with the slow disintegration times of formulation C's tablets. Dissolution rates of formulations C and D decreased with time and increased stress conditions, with the effect more pronounced in the case of formulation C. It can be concluded from the stability results that 5% Disolcel® as disintegrant was superior to a 2% concentration and to Kollidon CL-M® in concentrations of 2% and 5% of the tablet mass. Formulation B (5% Disolcel®) was chosen as the most favourable formulation with the best marketing possibilities. Stability results were also used to determine storage conditions and set specifications for batch release and stability to ensure that all batches tested against these specifications, meet the requirements for quality, safety and efficacy.<br>Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2008.

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Noutchang, Yves Roland Tchakounte. "Design and evaluation of fast dispersible tablets of lamivudine using selected natural superdisintegrants." University of the Western Cape, 2018. http://hdl.handle.net/11394/6781.

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Magister Pharmaceuticae - MPharm<br>Fast dispersible tablets (FDTs) are solid single-unit dosage forms that are placed in the mouth and allowed to disperse or dissolve in the saliva without the need of water. The basic approach to formulating FDTs consists of adding a superdisintegrant to a tablet formulation. These tablets offer both the advantages of conventional tablets and liquid dosage forms along with distinctive properties which include accurate dosing, ease of administration, quick onset of action, enhanced bioavailability, and increased patient adherence. FDTs have been found to be effective in remedying therapeutic in-adherence caused by dysphagia (swallowing difficulties) particularly in paediatric and geriatric subjects. There is a strong correlation between therapeutic success and patient adherence especially with HIV/AIDS treatment regimens, consequently the dosage form should be patient friendly and devoid of unappealing characteristics. This study aimed at developing a cost effective fast dispersible tablet of lamivudine using alternative excipients and conventional techniques. Only conventional tablets and oral liquid dosage forms of lamivudine are available on the South African market. Two natural polymers reported to have superdisintegrating properties were selected to serve as multipurpose excipients in this study. The polymers were identified, characterised and compared using thermal, spectroscopic and micromeritic analytical tools. The polymer that displayed the best characteristics in terms of micromeritic, tableting and disintegrating properties was retained and used for the optimum formulation. The optimum formulation was composed of 150 mg of lamivudine, 23% w/w unripe banana powder and 2% w/w magnesium stearate. FDTs of lamivudine were obtained using the compression technique with and without wet granulation. The tablets were assessed as per the United States Pharmacopoeia (USP) guidelines and other evaluation procedures pertaining to FDTs. The wet granulated tablets were found to be less friable and thus more resilient than the directly compressed tablets. In-vitro disintegration of the wet granulated tablets occurred within 50±3 sec in deionised water (pH 7) and 35±2 sec in a phosphate buffer solution (pH 6.8). Consequently, the innovative tablets fulfilled the core requirement of FDTs i.e. rapid disintegration. Drug release studies were carried out by analysing dissolution aliquots of the innovative tablets using a validated High Performance Liquid Chromatography (HPLC) method, and comparing them to Aspen Lamivudine®, a conventional tablet of lamivudine presently on the South African market. Complete dissolution in deionised water (pH 7) was attained within 10 minutes and 30 minutes for the innovative tablets and Aspen Lamivudine® respectively.

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Labuschagne, Joseph Willem. "The formulation and stability of dispersible or chewable tablets containing anti retroviral drugs / Joseph Willem Labuschagne." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1638.

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Uslu, Sibel. "Formulation development and characterization of liquisolid tablets containing clozapine." Thèse, 2014. http://hdl.handle.net/1866/11571.

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L’objectif de ce projet était de développer une formulation liquisolide (LS) de clozapine ayant des propriétés de dissolution améliorées et évaluer sa stabilité et ainsi que sa robustesse à la modification d’excipients. Le propylène glycol (PG), la cellulose microcrystalline (MCC) et le glycolate d’amidon sodique (SSG) ont été utilisés respectivement en tant que véhicule liquide non volatile, agent de masse et agent désintégrant pour la préparation de comprimés LS. Le dioxyde de silicium colloïdal (CSD), le silicate de calcium (CS) et l'aluminométasilicate de magnésium (MAMS) ont été choisis comme agents d’enrobage sec. La caractérisation complète des mélanges et des comprimés a été effectuée. Le taux de libération des comprimés LS était statistiquement supérieur à celui des comprimés réguliers. La surface spécifique des matériaux d’enrobage avait un effet sur les propriétés d’écoulement des mélanges et la taille des particules des matériaux d’enrobage a eu un effet sur la vitesse de dissolution. Le ratio support/enrobage du mélange de poudres (valeur de R) était un paramètre important pour les systèmes LS et devait être plus grand que 20 afin d’obtenir une meilleure libération du médicament. La formulation choisie a démontré une stabilité pour une période d’au moins 12 mois. La technique LS s’est avéré une approche efficace pour le développement de comprimés de clozapine ayant des propriétés de dissolution améliorées. Les comprimés oro-dispersibles (ODT) sont une formulation innovante qui permettent de surmonter les problèmes de déglutition et de fournir un début d'action plus rapide. Dans l’optique d’améliorer les propriétés de dissolution, un essai a été effectué pour étudier la technique LS dans la formulation des ODT de clozapine. Le PG, la MCC, le CSD et la crospovidone (CP) ont été utilisés respectivement en tant que véhicule liquide non volatile, agent de masse, agent d’enrobage sec et agent superdésintégrant pour la préparation de comprimés oro-dispersibles liquisolides (OD-LST). Le mannitol a été choisi comme agent de masse et agent édulcorant. La saccharine de sodium a été utilisée comme agent édulcorant. La caractérisation complète des comprimés a été effectuée. Le taux de libération des OD-LSTs était statisquement supérieur comparativement aux comprimés ODTs. La formulation choisie a démontré une stabilité pour une période d’au moins 6 mois. Il a été conclu que des ODT de clozapine peuvent être préparés avec succès en utilisant la technologie LS dans le but d’améliorer la désintégration et le taux de dissolution de la clozapine dans la cavité orale.<br>The objective of this research was to develop a liquisolid (LS) formulation of clozapine with improved dissolution properties and evaluate its robustness to excipient modifications as well as its stability. Propylene glycol (PG), microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) were employed as non-volatile liquid vehicle, carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxide (CSD), calcium silicate (CS) and magnesium aluminometasilicate (MAMS) were selected as coating materials. Complete characterisation of the blends and tablets was performed. The drug release rates of LS compacts were distinctly higher as compared to regular tablets. The specific surface areas of coating materials had an effect on the flow properties of the blends and the particle sizes of coating materials affected the dissolution rate. The carrier : coating ratio of the powder system (R value) was an important parameter for LS systems and had to be larger than 20 to obtain enhanced drug release. The selected formulation demonstrated stability for a period of at least 12 months. The LS technique was an effective approach to prepare clozapine tablets with enhanced dissolution properties. Orally disintegrating tablets (ODT) constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing dissolution properties an attempt has been made to study LS technique in formulation of ODT of clozapine. PG, MCC, CSD and crospovidone (CP) were employed as non-volatile liquid vehicle, carrier material, coating material and superdisintegrant respectively for preparing orally disintegrating liquisolid tablets (OD-LST). Mannitol was selected as a carrier material and sweetening agent. Sodium saccharin (SS) was employed as a sweetening agent. Complete characterisation of the tablets was performed. The drug release rates of OD-LSTs were distinctly higher as compared to regular ODTs. The selected formulation demonstrated stability for a period of at least 6 months. It was concluded that the ODT of clozapine can be successfully prepared using LS technology in order to improve disintegration and dissolution rate of clozapine in oral cavity.

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Oliveira, Tânia Patrícia Abreu. "Preparation of scored orodispersible tablets with a new type of punches using design of experiments." Master's thesis, 2016. http://hdl.handle.net/10451/35894.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Oral drug delivery continues to be the most preferred route for administration of various therapeutic agents. A lot of research has been done in the sense of discovery and develop new drug delivery systems. This work focus on the development of orodispersible tablets as an alternative to other solid dosage forms, especially for people who have difficulty in swallowing (dysphagia) or who need a rapid onset of therapeutic action in order to increase bioavailability. Quick absorption, rapid onset of action and increased bioavailability (by decreasing the first-pass effect) are the main advantages associated to this dosage form. The objective of the present study was to optimize, formulate and evaluate orally dispersible tablets (ODTs) of Furosemide presenting score lines using a new type of punches (Easy Breakable Tablet -EBT). Tablets were prepared by Direct Compression at relatively low pressure forces. Afterwards, the tablets obtained were evaluated in terms of weight variation, thickness, diameter, friability, hardness, disintegration time, wetting time, water absorption ratio, effervescence time and uniformity content. Through Design of Experiments (DoE), was evaluated the relationship between factors or independent variables (force, weight, speed and punch type) and the response variables or dependent variables (e.g. tablets thickness). Taking into consideration the desirability approach, the desired levels for each factor were determined to obtain ODTs with the most convenient characteristics. The tablets obtained revealed good mechanical properties but prolonged disintegration times. Considering that they are orodispersible tablets which are intended to be dispersed in the mouth in a matter of seconds, these results arise the need to realize further studies in order to improve the tablets disintegration efficacy.<br>A via de administração oral continua a ser a preferida para a administração de diversos agentes terapêuticos. Muitas pesquisas têm sido feitas no sentido de descobrir e desenvolver novos sistemas de veiculação de fármacos. Este trabalho centra-se no desenvolvimento de comprimidos orodispersíveis como alternativa a outras formas farmacêuticas sólidas, principalmente em pessoas que apresentam dificuldade em deglutir (disfagia) ou que precisam de um rápido início de ação terapêutica de forma a aumentar a adesão à mesma. Rápida absorção, rápido início de ação e aumento da biodisponibilidade (por redução do efeito de primeira passagem) são as principais vantagens associadas a esta forma farmacêutica. O objetivo do presente trabalho foi otimizar, formular e avaliar comprimidos orodispersíveis de Furosemida contendo linhas de quebra utilizando um novo tipo de punções (Easy Breakable Tablets- EBT). Os comprimidos orodispersíveis foram produzidos por compressão direta utilizando forças de compressão relativamente baixas. De seguida, os comprimidos preparados foram avaliados em termos de variação de massa, espessura, diâmetro, friabilidade, resistência ao esmagamento, tempos de desintegração, de molhamento e de efervescência, quantidade de água absorvida e uniformidade de teor. Através do desenho experimental, foi avaliada a relação entre os fatores ou variáveis independentes (força, massa, velocidade e tipo de punção) e as variáveis de reposta ou variáveis dependentes (ex. espessura dos comprimidos). Por fim, através da metodologia desirability foram determinados os níveis ideais para cada fator de forma a obter os comprimidos com as características mais convenientes. Os comprimidos obtidos mostraram ter boa resistência mecânica, mas tempos de desintegração muito prolongados. Considerando que se tratam de comprimidos orodispersíveis destinados a dispersarem na cavidade oral em segundos, estes resultados levantam a necessidade de realizar mais estudos no sentido de melhorar a velocidade de desintegração dos comprimidos.

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Books on the topic "Dispersible tablets"

1

Appapurapu, Ashok kumar. Oro dispersible tablets: Effect of superdisintegrants. LAP Lambert Academic Publishing, 2015.

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Rao, Tentu Nageswara, Shradha Devi Kappari, and Sai Raj Kappari. Formulation development of deferasirox dispersible tablet. LAP Lambert Academic Publishing, 2015.

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Book chapters on the topic "Dispersible tablets"

1

Buras, B., W. I. F. David, L. Gerward, J. D. Jorgensen, and B. T. M. Willis. "Energy-dispersive techniques." In International Tables for Crystallography. International Union of Crystallography, 2006. http://dx.doi.org/10.1107/97809553602060000580.

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B., Raja Narender, and T. Gayathri. "Design and Evaluation of Oro-Dispersible Tablets of Tramadol Hydrochloride." In Advanced Concepts in Pharmaceutical Research Vol. 9. B P International, 2024. http://dx.doi.org/10.9734/bpi/acpr/v9/3764g.

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N'Goran, Eliézer, N'da Angbeletchi David Aka, Mamadou Ouattara, Eric Huber, Deon Bezuidenhout, and Elly Kourany-Lefoll. "Challenges and Lessons From Conducting A Paediatric Clinical Trial in Sub-Saharan Africa: The Case of the Praziquantel Oral Dispersible Tablets Phase II Study in Côte d’Ivoire." In Highlighting Operational and Implementation Research for Control of Helminthiasis. Elsevier, 2019. http://dx.doi.org/10.1016/bs.apar.2018.09.002.

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"Table of Contents." In Dispersione Ordine Distanza. Quodlibet, 2020. http://dx.doi.org/10.2307/j.ctv17z842c.2.

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Pascarelli, Sakura, and Olivier Mathon. "Energy-scanning and energy-dispersive spectrometers for XAFS." In International Tables for Crystallography. International Union of Crystallography, 2023. http://dx.doi.org/10.1107/s1574870722003160.

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Biborski, Marcin, and Mateusz Biborski. "Badania składu chemicznego oraz technologia wykonania wybranych zabytków ze stopu miedzi." In Ocalone Dziedzictwo Archeologiczne. Wydawnictwo Profil-Archeo; Muzeum im. Jacka Malczewskiego w Radomiu, 2020. http://dx.doi.org/10.33547/oda-sah.10.zn.11.

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41 artefacts recovered from the Przeworsk culture cemetery in Żelazna Nowa were originally selected for archaeometric examination. Of that number, 24 brooches and 13 various objects made from copper alloy were analysed. The choice was dictated by their good state of preservation, allowing for reliable results. The method applied was non-destructive energy dispersive X-ray fluorescence analysis (ED-XRF), using an X-ray spectrometer operating at 45kV. In addition, selected artefacts were examined using a scanning electron microscope. The results of chemical analyses are presented in Tables 11.1 and 11.2, with weight percent values given, while the raw material and technical data are shown in Tables 11.3 and 11.4. The results indicate that among the 24 brooches and their fragments analysed, 16 were made of brass, including eight made of multi-component tin brass, one made of tinlead brass, and one made of tin-silver brass. Among the remaining eight brooches one was made of iron and seven were bronze pieces, including two made of multi-component zinc bronze, one of lead bronze, and one of silver bronze (inv. no. CCXXIII/15). The addition of lead had significant technological impact on the alloys used for creating the brooches. Even in small quantities, even far below 1%, this element improves the castability and workability of the metal. Zinc, in turn, is added to bronzes as a reducing agent, making the alloy self-reducible. This also makes it possible to reduce the contents of phosphorus. Moreover, the addition of zinc to bronze significantly lowers its melting temperature. The remaining alloying additions (apart from elements recorded in trace amounts, like Ag, Sb, and Fe, which naturally occurred in copper alloys) have had no significant impact on the quality of the raw material used for manufacturing the artefacts under discussion. The presence of silver (a few percent) recorded in two brooches (inv. nos XXXIII/15 and CCXXIII/15) indicates they may have originally been silver-plated. Two brooches (inv. nos XCIX/15 and 21/08) were inlaid with silver wire. The first one was cast from tin bronze and adorned with a filigree wire (Fig. 11.1) in the type of a simple braid, made of highquality (92.99%) silver (Fig. 11.2). The silver wire with a diameter of merely 338.38 μm (Fig. 11.3) was produced by drawing through a die, and it was later braided and hammered into grooves previously prepared on the two crests of the brooch. The second brooch, made of iron (inv. no. 21/08), was adorned with silver of a similarly high quality (91.85%). In this case, however, the exposure to fire resulted in complete destruction of the decoration: its traces only remained in a few places in the form of tiny melt-down droplets. It is worth noting the similar standard of silver used as inlays in both brooches. This seems to corroborate the assumption that the standards of silver used in trade were generally similar over larger areas. It is worth noting two brooches which, despite representing different types, are made of chemically very similar alloys (Tables 11.1–3). One (inv. no. CCIX/15) belongs to type A.III.58, while another represents group A.IV (inv. no. CIX/17). This may indicate that both were manufactured in the same workshop. Except for one brooch forged from iron, all the remaining brooches were cast using the lost wax technique (Table 11.3). Cast pieces also prevail among other artefacts, especially those having profiled surfaces (Table 11.4). Examples include a fragment of a J.7 shield grip (inv. no. XVI/15), a belt finial of type “O” (inv. no. CCXLIX/15), and fragments of bracelets with round terminals (inv. nos XIII/15 and LXXXVI/17). The performed raw material analysis of copper alloy artefacts from Żelazna Nowa produced interesting findings. The results confirm that during the Older Roman Period brass artefacts prevailed among small metal dress items in the Przeworsk culture. Among the 37 copper alloy artefacts analysed, as many as 27 (75%) are brass objects. A similar picture was observed in other sites, with a prevalence of brass artefacts recorded in cemeteries such as those in Karczyn/Witowy, Sadłów, and Szarbia.

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"The non-dispersive interaction energy between glass and water as a function of pH is expected to reflect the surface charge generated by the exposed chemical functions on the clean glas s surface. The variations in surface charge, generated by the exposed SiOH and aluminum oxide groups, is expected to give rise to fea-tures representing the surface chemistry of the clean glass. The scatter i n the data shown in Figures 4 and 5 allows only general trends to be discerned. The p.z.c.'s at pH 3 and 9 have been described in the preceding paragraphs. It is interesting to note that the chromic acid cleaned glass surfaces behave in a similar manner, showing virtually identical trends. The pyrolysis cleaned glass surfaces show dif-ferences in their behavior across the different glass compositions. These trends correlate with those observed for organic contamination of these surfaces, as de-scribed in Section 3.1, where the chromic acid cleaned glass surfaces all showed similar behavior, while the pyrolyzed glass showed significant differences in its sensitivity to contamination. In particular, the pyrolyzed silica surface shows far lower non-dispersive interaction energy with water than the pyrolyzed Corning code 1737 or sodalime glasses. This features correlates with the high degree of adsorbed contamination, described in Section 3.1, for the pyrolyzed silica surface. The datum in Figure 5 for the non-dispersive interaction energy between a py-rolyzed silica surface and water at pH 7 corresponds to a contact angle of 31°. This is significantly higher than the contact angle of water on a pyrolyzed silica surface freshly immersed into liquid octane. While the surface cleanliness was measured after cleaning, it was not measured after substrate immersion in the acidic or alkaline solutions. It is possible that the comparatively low non-dispersive interaction energy observed for pyrolyzed silica is partially an artifact caused by contamination of the cleaned silica before immersion into liquid oc-tane. Figure 4 shows similar behavior fo r the glass surfaces, suggesting that the alu-minoborosilicate and sodalime glasses show behavior similar to that of a silica surface. This phenomenon may be due to the leaching of soluble alkaline oxides from the glass surfaces during chromic acid cleaning, leaving a surface enriched in silica that behaves essentially in the same way as a chromic acid cleaned silica surface. In Figure 5, the minimum in the non-dispersive interaction energy between glass and water at pH 9 is not present for pyrolyzed sodalime glass. This mini-mum was presumed to be associated with a high sodium ion concentration in solution, neutralizing the SiO" groups at the glass surface. The presence of sodium oxide (see Table 1) in the sodalime glass composition may generate a high so-dium environment for the the silano l groups at the glass surface. The high sodium concentration in the glass may thus be equivalent to a high sodium concentration in solution, neutralizing the p.z.c." In Surface Contamination and Cleaning. CRC Press, 2003. http://dx.doi.org/10.1201/9789047403289-16.

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Conference papers on the topic "Dispersible tablets"

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Ochoa, Maité, Silvia B. Farina, and Martín A. Rodríguez. "Crevice Corrosion of Copper as an Engineering Barrier of High-Level Radioactive Waste Containers." In CORROSION 2017. NACE International, 2017. https://doi.org/10.5006/c2017-09162.

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Abstract This work is aimed at determining the viability of oxygen-free copper as an engineering barrier of high-level radioactive waste containers. This material stands out because of its excellent resistance to generalized and localized corrosion in aqueous electrolytes; particularly in reducing environments as the ones expected in repository sites located below the water table. As the first part of a more general analysis, the corrosive effects of different ions potentially in contact with the barrier were studied. Eight systems with different concentrations of chloride, sulfate and bicarbonate (0.001 to 1 M) and different temperatures (30 to 90 °C) were selected. Open circuit potential tests and Potentiodynamic-Galvanostatic-Potentiodynamic tests were performed to determine the existence of crevice corrosion. Artificial crevice formers were used. Scanning electron microscopy and optical microscopy were used to characterize the creviced specimens after testing. Corrosion products composition was determined by Energy Dispersive Microanalysis. The crevice corrosion tests showed that crevice corrosion is observed only in some of the 8 selected solutions. The corrosion was not very deep and it occurred below the edges of the crevice formers. Some corrosion was observed out of the crevices, in the bulk zone, indicating the possible occurrence of inverse crevice corrosion.

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Saricimen, H., N. R. Jarrah, and I. M. Allam. "Investigation of Corrosion of Commercial Grade AISI 316L Stainless Steel Liner Plates in Desalination Plant Conditions." In CORROSION 1994. NACE International, 1994. https://doi.org/10.5006/c1994-94505.

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Abstract The corrosion of AISI Type 316L stainless steel (316L SS) liner plates in the flash chambers of a multistage flash (MSF) desalination plant, located on the Arabian Gulf coast was investigated. The 316L SS liner plates developed severe corrosion within six years of operation. This study was conducted to develop an understanding of the mode and causes of corrosion of the liner plates, and to determine the effect of heat treatment (annealing or heat effect during welding) and temperature of salt solution on corrosion of the liner plates. Specimens of the liner plates were studied in as-received (AR) condition and after being heat treated (HT) at 900°C in air and air-cooled to room temperature. Electrochemical techniques were used to measure the corrosion of the specimens. Scanning electron microscope (SEM) installed with energy dispersive (ED) X-ray diffraction capability was used for identification of compositional and structural changes in the specimens during heat treatment and corrosion. The results showed that:(1) Commercial grade 316L SS is susceptible to pitting, crevice and grain boundary corrosion under the operating conditions in the desalination plant. The heat-affected-zone (HAZ) had larger grains and corroded more severely than other parts of the liner plates. (2) The liner plates had randomly distributed inclusions containing Ti, Cr, Mo, Mn, and S in the structure. (3) Measurement of the corrosion rate, and (4) Metallographic investigation of the AR and HT samples. Sample Preparation The test samples were machined from 2 mm thick 316L SS liner plates, in circular shape with 16 mm diameter. The samples were prepared from weld zone including HAZ and normal liner plates. Some of the samples, both from HAZ and plate, were studied in as-received condition. The remaining of the liner plate samples were investigated after a heat treatment to simulate welding conditions in the SS samples. Table 1 shows elemental analysis of 316L SS samples used in this investigation. Five samples were prepared for metallographic examination: All of the specimens (AR, HAZ and HT) used for electrochemical testing were polished with SiC paper to 600 grit finish. They were then degreased with acetone, washed with distilled water, and dried in air. Heat Treatment The heat treatment was designed to simulate, as closely as possible, the conditions that HAZ is subjected during welding. The 316L SS plate samples were first solution annealed at 900°C for 20h or 120h in air in a laboratory furnace to ensure dissolution of carbide precipitates, if any, and cause appreciable grain growth. Following the solution annealing the samples were cooled in air to simulate the cooling rate during welding and induce sensitization at grain boundaries. The samples were then polished to 0.5 micron surface finish prior to electrochemical tests. (3) The corrosion rate of the AR samples of the liner plates was the lowest. It was followed by corrosion rates of HT and HAZ samples respectively in ascending order.

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Zhao, Jiangli, Xiangyang Wu, Dongsheng Jia, Yanmin Zou, Ye Zhou, and Liuqing Yang. "Study on preparation of Prunella dispersible tablets." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5965245.

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Liuqing Yang, Wenwen Wang, Ye Zhou, et al. "Simultaneous determination of schisantherin and deoxyschizandrin in dispersible tablets of Fructus Schisandrae Sphenanthera." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5965514.

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Guo, Wanwei. "IDDF2023-ABS-0142 Observation of the clinical therapeutic effect of mosapride citrate dispersible tablets in combination with flupentixol and melitracen tablets in the treatment of functional dyspepsia in the elderly." In Abstracts of the International Digestive Disease Forum (IDDF), Hong Kong, 10–11 June 2023. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2023. http://dx.doi.org/10.1136/gutjnl-2023-iddf.81.

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Pakhlavonova, Aziza, Valentina Aksenova, Nadezhda Klevno, and Alexey Kazakov. "Acceptability of a new child-friendly dispersible tablet for drug-sensitive pulmonary tuberculosis in children." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.1564.

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Carpenter, Joshua H., Dean Hazineh, Michael E. Gehm, and Joel A. Greenberg. "Quantifying crystalline texture with a tabletop energy and angle dispersive diffractometer for material identification (Conference Presentation)." In Anomaly Detection and Imaging with X-Rays (ADIX) V, edited by Amit Ashok, Michael E. Gehm, and Joel A. Greenberg. SPIE, 2020. http://dx.doi.org/10.1117/12.2560077.

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Schmale, I., F. van Raay, and G. Kompa. "Dispersive table-based large-signal FET model validated in analysis of MMIC frequency doubler." In 26th European Microwave Conference, 1996. IEEE, 1996. http://dx.doi.org/10.1109/euma.1996.337567.

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Yulianto, Agus, Agung Setyo Darmawan, A'an Candra Mustika, Bambang Waluyo Febriantoko, and Patna Partono. "Characterization of Gray Cast Iron with the Addition of 3 Wt.% FeMn in the Casting Process with Metal Molds and Sand Molds." In 6th International Conference on Advanced Materials Science. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-rt48g1.

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This study aims to determine how the effect of inoculation of manganese (FeMn) on the hardness value, the results of microstructure photos, and the results of the Scanning Electron Microscopy Energy Dispersive X-ray Spectroscopy, test on gray cast iron material with the addition of 3% FeMn. In this casting process using an induction smelting furnace with a temperature of 1300 – 1400 C the material used for smelting is iron (Fe), melted and then mixed with 3%. FeMn after mixed poured into metal molds and prepared sand. The results of the hardness test showed that the hardness values vary in the upper, lower, and intermediate metal molds. The results of microstructure testing of metal molds, transitional molds, and sand molds at the bottom are the hardest because the graphite is neatly arranged and clearly visible. The results of the Scanning Electron Microscopy Energy Dispersive X-ray Spectroscopy test of the Mn element in the metal mold was detected at 3.45% and in the sand mold at 0.00%, the Mn sand mold was actually detected on the graph but did not appear in the data table because it was covered by Fe, C, and Si elements.

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Vardanyan, A. G., N. F. van Hulst, J. Ranger, C. Otto, and J. Greve. "Polarisation-sensitive coherent anti-Stokes and spontaneous Raman spectroscopy of caiix[4]arene films." In The European Conference on Lasers and Electro-Optics. Optica Publishing Group, 1994. http://dx.doi.org/10.1364/cleo_europe.1994.cwf93.

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Novel organic molecules with high nonlinear optical properties are an important subject of investigation because of their potential application in optical communication, frequency conversion, etc.1 Here, we present the experimental results of spontaneous Raman, polarisation sensitive CARS (PS-CARS) and waveguide CARS of the newly synthesised organic molecule tetranitro-tetra-(n-propoxy)calix[4]arene (c40h44n4o12) in thin films. For assignment of most specific strong Raman bands of calix[4]arene, a comparative analysis and different derivatives of this molecule were used. In addition, the depolarisation ratios for most of the bands were estimated by polarisation sensitive spontaneous Raman and CARS independently. Several strong bands are present in the Raman spectrum of calix[4]arene: Ω = 1095 cm−1, Ω = 1265 cm−1, Ω = 1340 cm−1, Ω = 1584 cm−1. The strongest band at Ω = 1344 cm−1 (ρ = 0.25) corresponds to the symmetric NO2 stretch. In Fig. 1 the PS-CARS spectrum for calix[4]arene in chloroform (C = 20 mg/ml) is shown. The result of fitting the spectrum with depolarisation ratios, taking into account the various settings of the polarizers is also shown. The observed line shape changes at different analyser settings around the position of background suppression illustrate the polarised character of the different bands. For example, the different dispersive shape of the chloroform band at Ω = 1214 cm−1 with ρ = 0.7 deviates from the bands of calix[4]arene with ρ < 0.7. In Table 1 the depolarisation ratios for calix[4]arene, as determined from the polarised Raman and PS-CARS spectra are summarised. The values agree well for both techniques.

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