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Nutan, Prakash Sharma, Pandey Shivam, and Sharma |. Jaya Singh Hariom. "A Review on Dispersible Tablets A Novel Drug Delivery System for Pedietrics and Geriatrics." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1188–92. https://doi.org/10.5281/zenodo.3590783.
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Novel Drug Delivery system offer great chance to invent new drug delivery system for the betterment of the life. Oral dispersible tablets are modern day technology and extensively used for those formulations which are required for pediatrics and geriatrics. Dispersible tablet disintegrates rapidly into the mouth in presence of saliva, as they don't require water for disintegration. Such rapid disintegration is helpful for the person having problem of dysphasia. Dispersible tablet requires a key ingredient called supradisintegrants for such rapid and effective disintegration. There are various methodologies used for preparing such effective dispersible tablets like - Compaction method, Freeze Drying, Molding Method, Sublimation, all such methods are effective to make dispersible tablets. There is need of evaluation of each and every tablet after manufacturing which requires evaluation parameters such as weight variation, Disintegration test, Dissolution Test, Hardness, and Thickness. This article discuss about dispersible tablets, methods of preparation for dispersible tablets, evaluation parameters and advantages and disadvantages. Nutan Prakash Sharma | Shivam Pandey | Hariom Sharma | Jaya Singh "A Review on Dispersible Tablets: A Novel Drug Delivery System for Pedietrics and Geriatrics" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25098.pdf
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Wang, Yifei, Zhisheng Wu, Zhaoyi Wang, Manfei Xu, Xinyuan Shi, and Yanjiang Qiao. "Rapid analysis of spatial distribution of PVPP and hardness of Yinhuang dispersible tablets by NIR-CI." Journal of Innovative Optical Health Sciences 09, no. 02 (2016): 1550016. http://dx.doi.org/10.1142/s1793545815500169.
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The present study aimed at investigating the relationship between tablet hardness and homogeneity of different Yinhuang dispersible tablets by near-infrared chemical imaging (NIR-CI) technology. The regularity of best hardness was founded between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets. The ingredients homogeneity of Yinhuang dispersible tablets could be spatially determined using basic analysis of correlation between analysis (BACRA) method and binary image. Then different hardnesses of Yinhuang dispersible tablets were measured. Finally, the regularity between tablet hardness and the spatial distribution uniformity of Yinhuang dispersible tablets was illuminated by quantifying the agglomerate of polyvinyl poly pyrrolidone (PVPP). The result demonstrated that the distribution of PVPP was unstable when the hardness was too large or too small, while the agglomerate of PVPP was smaller and more stable when the best tablet hardness was 75[Formula: see text]N. This paper provided a novel methodology for selecting the best hardness in the tabletting process of Chinese Medicine Tablet.
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Shivam, Pandey, Hariom Sharma Dr., and Singh Jaya. "Review on Novel Drug Delivery System and Antihypertensive Tablets." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1283–86. https://doi.org/10.5281/zenodo.3590981.
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Novel drug delivery system offers excellent opportunity to the inventors for developing new technologies for drug administration, dispersible tablets are come under this category as it offers various advantages over conventional tablets. Dispersible tablets offer rapid disintegration in the mouth while came in contact with saliva. It is good find and rapid solution for the problem of dysphasia among geriatrics, as they feel some problem in swallowing a tablet. This article discuss about dispersible tablets, dysphasia, advantages and disadvantages of dispersible tablets. It also discuss about hypertension and antihypertensive tablets. Shivam Pandey | Dr. Hariom Sharma | Jaya Singh "Review on Novel Drug Delivery System and Antihypertensive Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25120.pdf
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Wademan, D. T., H. R. Draper, S. E. Purchase, et al. "Acceptability of levofloxacin dispersible and non-dispersible tablet formulations in children receiving TB preventive treatment." IJTLD OPEN 1, no. 2 (2024): 69–75. http://dx.doi.org/10.5588/ijtldopen.23.0462.
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<sec><title>BACKGROUND</title>We evaluated the palatability and acceptability of a 100 mg dispersible and a non-dispersible 250 mg levofloxacin (LVX) tablet formulation in children.</sec><sec><title>METHODS</title>Perform was a randomised, open-label, cross-over trial of the relative bioavailability of LVX dispersible vs. crushed non-dispersible tablets in children aged <6 years routinely receiving TB preventive treatment. Children and caregivers completed Likert- and ranking-type measures on the acceptability of both formulations. We used summary, comparative and ranking statistics to characterise formulation acceptability.</sec><sec><title>RESULTS</title>A total of 25 children were enrolled (median age: 2.6 years, IQR 1.6–4.0). Caregivers reported frequent challenges with preventive therapy in routine care prior to study entry, including taste of tablets (n = 14, 56%), vomiting/spitting out medicines (n = 11, 44%), and children refusing medicines (n = 10, 40%). Caregivers reported that the dispersible formulation was easier for their child to take than the non-dispersible formulation (P = 0.0253). Mean ranks for caregiver’s formulation preferences (dispersible tablets: 1.48, SD ±0.71; non-dispersible tablets: 2.12, SD ±0.67; routinely available formulations: 2.40 SD ±0.82) differed significantly (Friedman’s F 11.120; P < 0.0038); post-hoc testing showed dispersible tablets were preferred over non-dispersible (P = 0.018) and routinely available LVX formulations (P < 0.001).</sec><sec><title>CONCLUSIONS</title>The dispersible LVX 100 mg tablet formulation was preferred and should be prioritised for integration into routine care.</sec>
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Jangid, Shubham, Akash Yadav, and Dinesh Kumar Jain. "DISPERSIBLE TABLET AS A FORMULATION FOR ORAL DRUG DELIVERY SYSTEM." Journal of Advanced Scientific Research 14, no. 01 (2023): 08–14. http://dx.doi.org/10.55218/jasr.202314102.
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Dispersible drug delivery methods are widely utilized nowadays to increase patient compliance and bioavailability. Overthe past years, dispersible tablets have gained a lot of attention as a preferable alternative to conventional tablets andcapsules due to increased patient compliance, improved solubility, and improved stability profiles. Dispersible tabletsmay be a better option, particularly for medications that react negatively to GI fluids, to cover up a medication's bittertaste, and for patients, who fall into the paediatric or geriatric categories, are bedridden, have recently undergonesurgery, or may have trouble swallowing conventional tablets and capsules. These tablets instantly break down in thewater to create the suspension. The key component of a dispersible tablet is the super disintegrants. When a dispersibletablet comes into touch with water, it becomes moist and swells significantly, quickly disintegrating.
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Khan, Sohail, Farya Zafar, Huma Ali, et al. "WATER DISPERSIBLE TABLETS." Professional Medical Journal 23, no. 09 (2016): 1022–25. http://dx.doi.org/10.29309/tpmj/2016.23.09.1688.
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Water dispersible tablets are considered to be an attractive alternate tothe conventional tablets. In this review we reported the information related to the desiredcharacteristic and formulation challenges of these formulations.
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Barge, Kajal, Shivali Tank, Bhagyashri Parab, Mangal Nagarsenkar, and Supriya Shidhaye. "Fexofenadine Hydrochloride Dispersible Tablets: A Taste Masking Strategy using Ion Exchange Resin." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 846–53. http://dx.doi.org/10.25258/ijddt.13.3.12.
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The pediatric population is more sensitive to allergies. Fexofenadine hydrochloride (FXD-HCL), a non-sedative antihistaminic drug, was chosen to create taste-masked patient-compliant pediatric dispersible tablets. Due to its bitter taste, fexofenadine hydrochloride is unsuitable for the formulation of dispersible tablets; therefore, Kyron T-134®, cation exchange resin was used to form a taste-masked complex with the drug to overcome its bitterness. The FXD HCL-resin complex was prepared using a kneading method and the complexation was confirmed by differential scanning calorimetry and FTIR studies. The FXD HCL-resin complex was evaluated for flow properties, degree of bitterness, assay and release study. Dispersible tablets were formulated by using a co-processed excipient, Granfiller-D211® containing croscarmellose sodium and crosspovidone, microcrystalline cellulose and mannitol. 22 factorial designs with two replicates optimized the dispersible tablets. The tablets, prepared using the direct compression technique on a single-stroke tablet compression machine, were elegant in appearance. Various pre and post-compression tests were conducted on all formulations. The tablets of hardness 3.5 kg/cm2 showed friability, disintegration time, assay within the compendial limit and showed immediate release of a drug (NLT 60% in 10 min and NLT 80% in 30 minutes) in 0.001 N HCl (pH 3). The DSC thermogram indicated partial amorphization of the FXD HCL. Dispersible tablets of fexofenadine hydrochloride and Granfiller-D®211 at 1:4 proportion was stable for one month at ambient and accelerated storage conditions.
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Schiermeier, Simone, and Peter Christian Schmidt. "Fast dispersible ibuprofen tablets." European Journal of Pharmaceutical Sciences 15, no. 3 (2002): 295–305. http://dx.doi.org/10.1016/s0928-0987(02)00011-8.
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Kumar, Voleti Vijaya, Nandhini M, Sreelekhaa T, et al. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Future Journal of Pharmaceuticals and Health Sciences 4, no. 1 (2024): 1–13. http://dx.doi.org/10.26452/fjphs.v4i1.548.
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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally liked because of their convenience, higher bioavailability, quick disintegration and breaking down of the medication. The various technologies utilized in the formulation of Orodispersible tablets (ODT) and their evaluation are the primary focus of this review.
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V, Vijaya Kumar. "Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants." Comprehensive Review of Oro Dispersible Tablets and Co Processed Super disintegrants 4, no. 1 (2024): 1–13. https://doi.org/10.5281/zenodo.14649969.
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Due to their ease of administration, self-administration, and improved patient compliance, solid dosage forms are most popular. The most normally utilized strong dose structures are tablets and capsules, which is challenging for pediatric and geriatric patients. Considering these prerequisites endeavors have been made to foster rapid dissolving Tablets. The solid dosage form of a medicine that dissolves in a matter of seconds when swallowed is known as orodispersible tablet. The utilization of Superdisintegrants improves the crumbling season of the tablet. Fast Dissolving Tablets are generally liked because of their convenience, higher bioavailability, quick disintegration and breaking down of the medication. The various technologies utilized in the formulation of Orodispersible tablets (ODT) and their evaluation are the primary focus of this review.
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Ms., Remya S. B., Subash Chandran M. P. Dr., and Aparna P. Ms. "Formulation and Evaluation of Cefixime Trihydrate Dispersible Tablets." International Journal of Trend in Scientific Research and Development 4, no. 1 (2019): 602–11. https://doi.org/10.5281/zenodo.3606058.
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Therapeutically active ingredients like tablet and capsule are conventional pharmaceutical dosage forms for manufacture, storage and ensure dosage uniformity. However, this dosage forms like capsules and tablets, often present ingestion problems such as difficulty in swallowing for the debilitated patients, particularly for paediatric and geriatric populations. This may result in a high incidence of non compliance and ineffective therapy, which may prove to be fatal in case of serious conditions. Suspension dosage forms could solve this problem, but they have other associated drawbacks like lower physical and chemical stability and high cost of manufacturing. Suspensions are also inconvenient to carry while travelling and also involve the risk of inaccurate measurement and dosing. Thus, there is a need for oral pharmaceutical composition, which can be taken orally without the need of swallowing it and act as a viable substitute for suspensions. Accordingly, provided are water dispersible tablet compositions, which can either be chewed or can be readily dispersed in water before oral administration. One of the key requirements of water dispersible tablet is they could dissolve in an aqueous medium within a short time period for example, less than three minutes, to form a smooth suspension without any coarse lumps. Dispersible tablets provide advantages of both tablets and liquid formulations. These are convenient to carry, easy to manufacture and more stable dosage forms. Ms. Remya S. B | Dr. Subash Chandran M. P | Ms. Aparna P "Formulation and Evaluation of Cefixime Trihydrate Dispersible Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29627.pdf
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Qureshi, Aminabi, Umaima Shaikh, Mehrunnisa Shaikh, Wafa Parkar, Maria Lal, and Mirza Salman Baig. "Solid Dispersion Incorporated Indomethacin Oro- Dispersible Tablet." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 5 (2024): 7580–88. https://doi.org/10.37285/ijpsn.2024.17.5.4.
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Aim: This study aimed to enhance the dissolution profile of indomethacin by formulating oro-dispersible tablets, using the Solid Dispersion technique and PEG 6000 and PVP K-30 as carriers. Method: Solid Dispersion (SD) of indomethacin were prepared using the kneading method. Pre-compression studies include evaluating granules' density and flow properties, while post-compression studies assessed tablet properties such as hardness, friability, wetting time, dissolution, drug content and material interactions. Result: All pre- and post-compressional parameters were found within pre-determined limits. FTIR indicated no remarkable interaction between the polymers and the drug in the SDs. The dissolution study showed that the formulation with a 1:1 ratio of indomethacin to PVP K-30 and PEG 6000 exhibited the fastest dissolution rate, releasing 99.53% of the drug within 15 minutes. Conclusion: The study successfully formulated oro-dispersible tablets of indomethacin using the SD technique with PVP K-30 and PEG 6000 as carriers. These SD granules exhibited excellent flow properties. Whereas tablets showed appropriate physical characteristics, and rapid dissolution rates, which can improve effectiveness of the drugs like indomethacin. This approach offers a promising solution for patients who have trouble taking tablets.
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Agarwal, Shivendra, and Raghvendra Misra. "A REVIEW ON: FORMULATION, TECHNOLOGICAL AND BENEFICIAL ASPECTS OF ORAL DISPERSIBLE TABLETS." International Journal of Pharma Professional’s Research (IJPPR) 14, no. 1 (2023): 92–99. http://dx.doi.org/10.48165/ijppronline.2023.14108.
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This review is about oral dispersible tablets a novel approach in drug delivery systems that are now a day’s more focused in formulation world, and laid a new path that, helped the patients to build their compliance level with the therapy, also reduced the cost and ease the administration especially in case of pediatrics and geriatrics. Oral dispersible tablets are advantageous for pediatric, geriatric mentally ill, nausea patients who have difficulty in swallowing conventional tablets and capsules. Using various excipients, evaluation tests marketed formulation and drugs used in the research area. The advantages of mouth dissolving dosage form are increasingly being recognized in both, industry and academia. Their growing importance has been underlined recently when European Pharmacopoeia adopted the term “Oral dispersible Tablet” as tablet that is to be place in the mouth where it disperses rapidly before swallowing. When ODTs are put on tongue they disintegrate instantaneously, releasing the drug which dissolve or disperses in the saliva. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down in to the stomach. In such cases, bioavailability of a drug is significantly greater than those observed from conventional tablet dosage form.
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Monika, Leel, Singh Priya, Verma Muskan, and Sharma Mohit. "A Review: Oral Dispersible Tablets." International Journal of Current Pharmaceutical Review and Research 13, no. 04 (2022): 25–34. https://doi.org/10.5281/zenodo.12664607.
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AbstractThe oral route of drug administration is speculated as one of the most acceptable route fordrug delivery. Recently the orally dispersible tablets have become the most desirable dosageforms especially for a special category of patients i.e. pediatric, geriatric, bedridden, mentallyill, and uncooperative patients. Quick disintegration, better patient compliance, enhancedbioavailability are some of the vital characteristics of orally dispersible tablets which makesit superior from other traditional dosage forms. It is the most prominent dosage form for thepatients which face difficulty in swallowing other conventional dosage forms. Basically theoro-dispersible tablets are defined as novel solid dosage form that provide the rapiddisintegration or dissolution of solid medicament to exhibit it as a solution or in suspensionform before administration. Reportedly, there are numerous drug candidates, which havebeen successfully formulated as orally dispersible tablets and have resulted in satisfactory invitro as well as in-vivo results. By going through this review, a researcher can easily becomefamiliar to this novel formulation, as this review gives an quick insight of the advantages,disadvantages, ideal characteristics, method of preparation, and evaluation parameters ofthe oral dispersible tablets.
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Shah, Ria, Disha Patel, Dhruvanshi Kothari, et al. "Formulation and Evaluation of Oral dispersible Tablet of Paroxetine Hydrochloride." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 41–47. http://dx.doi.org/10.22270/jddt.v11i4.4921.
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Orodispersible tablets (ODTs) is one such novel approach which helps to increase user acceptance by virtue of rapid disintegration, self-administration without water or chewing. ODTs are solid unit dosage forms like the conventional tablets containing super disintegrants, which help them to disintegrate and/or disperse rapidly in the mouth within few seconds. The orodispersible tablet of Paroxetine hydrochloride was prepared by using direct compression method and the tablet were formulated using various concentration of Kyron T-314 as disintegrating agent, PVP K-30 as binder, F melt Type C as diluent, Sodium Saccharin as sweetening agent, talc as lubricant and Aerosil as glidant respectively. All the batches were prepared according to Factorial design. The prepared tablets were evaluated for various parameters like hardness, dissolution, friability, weight variation, disintegration time. Batch F5 was found to be the best batch as the disintegration time is minimum (26seconds) and better drug release profile. Orodispersible tablets of Paroxetine Hydrochloride were successfully formulated by which first pass metabolism could be avoided and faster onset of action could be achieved.
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Rohana, Evieta, Nuraini Ekawati, and Insilia Ivanna Hapsari. "Development and validation of a dissolution test for andrographolide dispersible tablets using UV-Vis spectrophotometry." Pharmacy Education 24, no. 6 (2024): 28–34. http://dx.doi.org/10.46542/pe.2024.246.2834.
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Background: Andrographolide, a terpenoid in an herbal plant, potentially has antidiabetic properties. Dispersible tablets are one of the pharmaceutical dosage forms used to improve acceptability. It is necessary to evaluate the dissolution profile to ensure the drug’s efficacy. Objective: This study aimed to determine the optimum condition of a dissolution test and its analysis for andrographolide dispersible tablets. Method: The optimisation process involves varying solvents, pH, and mole ratio of ARS-Cu(II)-andrographolide to determine the best conditions for the dissolution test of andrographolide dispersible tablets. Validation and analysis are conducted using spectrophotometry UV-Vis. Results: The optimal condition for the dissolution test was obtained with type II at 75 rpm, 900ml of citrate buffer medium with pH 3.1, and a temperature of 37±0.5ºC. The optimal analysis condition for the aliquot was obtained with Cu(II) metal and ARS reagents at pH 7, mole ratio 6:1:1.8, and a 15-minute optimum time. The maximum wavelength was 518nm using a UV-Vis spectrophotometer. The validation method has met the requirements. Conclusion: A dissolution test and its analytical method of andrographolide dispersible tablet have been validated.
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Khan, MD Abdul Aali, M. S. Sudheesh, and Rajesh Singh Pawar. "Formulation Development and Evaluation of Oro-Dispersible Tablets Based On Solid Dispersion of Cimetidine." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 42–46. http://dx.doi.org/10.22270/jddt.v12i6-s.5696.
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The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. The objective of present study was to formulate directly compressible orodispersible tablets of cimetidine with improved solubility and bioavailability by using solid dispersion technique. Cimetidine is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease and erosive esophagitis. Solid dispersion of cimetidine was prepared by anti-solvent addition method and physical mixture using novel polymer eudragit E 100. Saturation solubility of drug was determined in physical mixture and solid dispersion formulation. The prepared solid dispersion formulations were further characterized by drug contents, HPLC, and encapsulation efficiency. Orodispersible tablets of cimetidine were prepared by direct compression method and blend was evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The tablets were prepared by using selected solid dispersion formulation and excipients with sodium starch glycolate as a superdisintegrant and evaluated for hardness, friability, weight variation, content uniformity, wetting time, dispersion time and in-vitro drug release. Orodispersible tablet shows wetting time 27±1 seconds and in-vitro drug release 93.20±3.181%, which is better as compare to tablet containing pure drug (82.36±1.986) within 20min. Thus formulation of orodispersible tablet of cimetidine solid dispersion showed increased solubility and bioavailability with patient complies and convenience.
 Keywords: Cimetidine, Orodispersible tablets, Solid dispersion, Anti solvent addition method, Superdisintegrant
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Nimisha Solanki, Arpit Gawshinde, Komal Tikariya, Umesh K. Atneriya, and Dharmendra Solanki. "A Review on Orodispersible tablet." IJPAR JOURNAL 12, no. 3 (2023): 358–61. http://dx.doi.org/10.61096/ijpar.v12.iss3.2023.358-361.
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The oral route is the most important and recommended route of drug administration. Oral route is the safest and convenient route of drug delivery because of wide range of drugs are administered through this route. Oro dispersible tablets are novel oral drug-delivery system as they have improved patient compliance and have some additional advantages compared to other oral formulation. Oral dispersible tablet are solid unit dosage forms, which disintegrate or dissolves quickly in the mouth within a minute in the presence of saliva without chewing or water. The dosage form containing super disintegrates which impart the quality of quick disintegration in the presence of saliva and also play an important role in the formulation of oral dispersible tablets. The present review is focused on ideal properties, objective, advantages and disadvantages and evaluation parameters.
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Djimdé, Abdoulaye A., Mamadou Tekete, Salim Abdulla, et al. "Pharmacokinetic and Pharmacodynamic Characteristics of a New Pediatric Formulation of Artemether-Lumefantrine in African Children with Uncomplicated Plasmodium falciparum Malaria." Antimicrobial Agents and Chemotherapy 55, no. 9 (2011): 3994–99. http://dx.doi.org/10.1128/aac.01115-10.
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ABSTRACTThe pharmacokinetic and pharmacodynamic properties of a new pediatric formulation of artemether-lumefantrine, dispersible tablet, were determined within the context of a multicenter, randomized, parallel-group study. In an exploratory approach, we compared a new pediatric formulation with the tablet formulation administered crushed in the treatment of African children with uncomplicatedPlasmodium falciparummalaria. Patients were randomized to 3 different dosing groups (weights of 5 to <15 kg, 15 and <25 kg, and 25 to <35 kg). Treatment was administered twice daily over 3 days. Plasma concentrations of artemether and its active metabolite, dihydroartemisinin (DHA), were determined at 1 and 2 h after the first dose of dispersible (n= 91) and crushed (n= 93) tablets. A full pharmacokinetic profile of lumefantrine was reconstituted on the basis of 310 (dispersible tablet) and 315 (crushed tablet) plasma samples, collected at 6 different time points (1 sample per patient). Dispersible and crushed tablets showed similar artemether and DHA maximum concentrations in plasma (Cmax) for the different body weight groups, with overall means of 175 ± 168 and 190 ± 168 ng/ml, respectively, for artemether and 64.7 ± 58.1 and 63.7 ± 65.0 ng/ml, respectively, for DHA. For lumefantrine, the populationCmaxwere 6.3 μg/ml (dispersible tablet) and 7.7 μg/ml (crushed tablet), whereas the areas under the concentration-time curves from time zero to the time of the last quantifiable plasma concentration measured were 574 and 636 μg · h/ml, respectively. For both formulations, descriptive quintile analyses showed no apparent association between artemether/DHACmaxand parasite clearance time or between the lumefantrineCmaxand the occurrence of adverse events or corrected QT interval changes. The results suggest that the dispersible tablet provides adequate systemic exposure to artemether, DHA, and lumefantrine in African children with uncomplicatedP. falciparummalaria.
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Khobragde, Deepak, Arun Kotha, K. Ravalika, Richa Gupta, and P. Vasu Kumar. "Oro-Dispersible Tablets of Ayurvedic Powder For improving Taste, Compliance, Ease and Accuracy of administration." International Journal of Advances in Scientific Research 2, no. 6 (2016): 131. http://dx.doi.org/10.7439/ijasr.v2i6.3458.
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Most of the ayurvedic medicines are in the form of powder. Being in powder form the administration of accurate dose with ease is a problem. They may have some kind of unacceptable bitter taste. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Oro-dispersible tablet which rapidly disintegrating in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Talisadi. Talisadi is a traditional Ayurvedic powder preparation well known and effective in various disorders of respiratory and digestive system. Using various excipients like super-disintegrants and sweeteners, different formulation of polyherbal drug Talisadi were formulated by direct compression method. The acceptable formulation, among all the developed formulations of oro-dispersible tablet was having a disintegrating time of 1 min and 10 sec and acceptable taste. Thus the study concludes that formulation of oro-dispersible tablets of ayurvedic powder preparation can be a good option to enhance acceptability, efficiency and easy and accurate administration of powder ayurvedic preparations like Talisadi.
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Pokhrel, Gopal, Ganga Kunwar, Jun Devi Rai, Sheela Thapa, Sudip Dhakal, and Prashant Basnet. "Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin." Nepal Journal of Health Sciences 2, no. 1 (2022): 90–97. http://dx.doi.org/10.3126/njhs.v2i1.47172.
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Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and are beneficial for renal impaired, bedridden and psychiatric patients. Objective: The study aimed to formulate oro-dispersible tablets of indomethacin with reduced adverse effects, better patient compliance, faster action, and convenience for patients. Methods: Oro-dispersible tablets of indomethacin were prepared using three different super disintegrants; crospovidone, croscarmellose sodium and sodium starch glycolate with three different concentrations (2.5%, 5.2%, and 7.7%) by direct compression method. The prepared tablets were evaluated for pre and post-compression parameters including bulk density, tapped density, compressibility index, angle of repose, Hausner's ratio, hardness, friability, wetting time, in vitro disintegration time, and in vitro drug release. Results: The percentage of drug released in 5 minutes of all formulations of Oro-dispersible tablets of Indomethacin was found to be 74.36% to 80.16% and the percentage of drug released in 10 minutes was 96.18% to 100%. All formulations showed disintegration time in the range of 19-78 seconds. The tablets prepared with 7.7% crospovidone (F6) shows faster disintegration (19 seconds) as compared to tablets prepared with sodium starch glycolate and croscarmellose sodium. The in-vitro dissolution studies showed that tablets of formulations batch containing 7.7% crospovidone releases 100% of the drug after 10 minutes which was fast released as compared to sodium starch glycolate and croscarmellose sodium. Conclusions: Oro-dispersible tablets of indomethacin prepared with crospovidone showed better disintegration time and dissolution profile as compared to other superdisintegrants.
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Bommana, Anusha* Girija Karike Koppula Maheshwari Ramya Sri Sura. "FORMULATION AND IN VITRO EVALUATION OF ORO DISPERSIBLE TABLETS OF LORAZEPAM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3945–53. https://doi.org/10.5281/zenodo.1249808.
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<em>The present investigation was done on lorazepam orodispersible tablets using super disintegrants. The prepared powder blend for all formulations was found to be within limits. Tablets were compressed using rotary tablet compression machine. Post compression studies like weight variation, hardness, thickness, friability, drug content, in vitro disintegration time were carried out which were found to be within limits. In vitro drug release studies revealed that Among all formulations F4 formulation were shown maximum drug release(99.99%) at 45 min. Among these three formulations F4 was considered as optimised formulation due to 2 mg of croscarmellose sodium.</em> <strong>Key words: </strong><em>Lorazepam, Super disintegrants, Orodispersble tablets.</em>
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Nandhini, J., and AN Rajalakshmi. "Formulation development of methylprednisolone dispersible tablets using quality by design approach." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 229–39. http://dx.doi.org/10.22270/jddt.v9i1-s.2328.
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The objective of this study was to enhance the solubility of Methylprednisolone by choosing micronized form of drug and to enhance patient compliance by formulating it as dispersible tablets using quality by design (QbD) approach. Dispersible tablets of Methylprednisolone were developed by 23 factorial design. In this study independent variables were concentrations of MCC 102, CCS and Magnesium stearate and dependent variables were disintegration time, hardness and dissolution. The resulting data was fitted into Design Expert Software (Trial Version) and analyzed statistically using analysis of variance (ANOVA). The response surface plots were generated to determine the influence of concentration of MCC 102, CCS and magnesium stearate on responses. The tablets were prepared by direct compression method by choosing micronized form of drug and formulations were evaluated for the standard of dispersible tablets. Results showed that no significant drug-polymer interactions in FTIR studies. According to QbD suggestion the formulation O1 (Desirability- 0.73) with MCC-38mg, CCS-3.5mg and magnesium stearate-2.5mg was formulated and evaluated. The disintegration time was found to be 69 seconds, hardness was found to be 64N and in vitro dissolution with in 30minutes. Optimized O1 formulation was within the limits of standards of dispersible tablets with increased water solubility and better patient compliance. Stability study on optimized O1 formulation showed that there is no significant changes during study period. Thus, O1 formulation was found to be stable. The study indicates that formulation of Methylprednisolone dispersible tablets by using QbD approach is a promising formulation development method.
 Keywords: Dispersible tablets, Methylprednisolone, Direct compression, Quality by Design and ANOVA.
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&NA;. "Azithromycin dispersible tablets approved in China." Inpharma Weekly &NA;, no. 1630-1631 (2008): 18. http://dx.doi.org/10.2165/00128413-200816300-00055.
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Fini, Adamo, Valentina Bergamante, Gian Carlo Ceschel, Celestino Ronchi, and Carlos Alberto Fonseca de Moraes. "Fast dispersible/slow releasing ibuprofen tablets." European Journal of Pharmaceutics and Biopharmaceutics 69, no. 1 (2008): 335–41. http://dx.doi.org/10.1016/j.ejpb.2007.11.011.
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Nilausen, D., R. Linde, and J. van Gerven. "Theperception of a new orally dispersible escitalopram tablet - in a bioequivalence study." European Psychiatry 26, S2 (2011): 1270. http://dx.doi.org/10.1016/s0924-9338(11)72975-3.
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IntroductionRapidly dissolving oral dispersible tablets (ODT) have been developed to overcome problems related to swallowing.ObjectivesEstablish bioequivalence between ODT and the immediate release (IR) escitalopram tablet and determine its perception by healthy subjects.MethodsIn a randomized, open-label, cross-over design, 30 healthy men received 20 mg escitalopram as ODT tablets (2 × 10 mg or 1 × 20 mg) or conventional tablets. Twenty blood samples were collected after each dose administration and pharmacokinetic parameters were determined using non-compartmental methods. Safety was assessed by self-reported adverse events (AE) and vital signs. Subjects completed a questionnaire relating to their perception of the ODT.ResultsStatistical analysis of systemic exposure to escitalopram showed that ODT was bioequivalent to IR escitalopram for the primary (log-transformed AUC0-inf and Cmax) and secondary parameters (Table 1). AE incidence was similar for both dosage forms and all AEs considered related to escitalopram were mild. There were no serious AEs. Subjects found the ODT to have a pleasant texture (98%), size (95%), a pleasant mint/peppermint taste (86%), and suitable for long-term treatment (96%).ConclusionODT escitalopram was bioequivalent to the conventional tablet. Based on the subjects’ perception of taste, texture and size ODT escitalopram is a convenient and pleasant alternative to the conventional tablet.[Table 1]
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Elawni, Alaa E., Zuheir Osman, Mohammed Salih, Waleed Elballa, and Mohammed Shayoub. "Implementation and comparison of different taste masking techniques to design and assess dispersible tablet formulations." Journal of Applied Pharmaceutical Research 10, no. 4 (2022): 1–13. http://dx.doi.org/10.18231/j.joapr.2022.10.4.1.13.
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The objective of this study was to assess the efficacy of several taste-masking techniques and to study the impact of different formulation variables on the physicochemical properties of dispersible tablets containing Ranitidine as a model drug. Ranitidine powder was taste masked using various techniques. Factorial design (24) was applied to design the set of tablet formulations. The four factors implemented were the manufacturing method, filler type, superdisintegrant type and superdisintegrant concentration. Levels selected were direct compression and wet granulation for the manufacturing method, microcrystalline cellulose and mannitol for the diluent type, sodium starch glycolate and croscarmellose sodium for superdisintegrant type, and 2% and 10% for superdisintegrant concentration. Granulation with calcium carbonate (ratio of 1:8) was the taste-masking method of choice to be implemented. The formulated tablets results revealed that the manufacturing method has a significant influence on all the tested physicochemical properties (p-values < 0.05) such as tablet’s weight variation, hardness, friability, and disintegration time. Croscarmellose sodium obtained better results than sodium starch glycolate. Both fillers obtained good properties when implementing direct compression method with croscarmellose sodium concentration of 2%, or wet granulation method with croscarmellose sodium concentration of 10%. Drug release was also increased by increasing concentration of croscarmellose sodium. These findings represent an easy manufacturing procedure with relatively low-cost materials that can be implemented to formulate dispersible tablets of bitter tasting drugs that will enhance patient compliance and lead to faster onset of action.
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Saini, Jyoti, and Megha Parashar. "Development and Evaluation of Polyherbal Dispersible Tablets Using Aqueous Leaf Extracts." Journal of Pharmaceutical Research International 37, no. 4 (2025): 79–86. https://doi.org/10.9734/jpri/2025/v37i47680.
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The increasing demand for natural and herbal medicines has prompted the exploration of polyherbal formulations as viable therapeutic options. Dispersible tablets offer advantages such as ease of administration and rapid onset of action. The objective of this study was to develop and evaluate polyherbal dispersible tablets incorporating aqueous leaf extracts of Camellia sinensis, turmeric, grape seed, oregano, and Salvia officinalis. Polyherbal dispersible tablets were formulated and evaluated for their physicochemical properties, disintegration, and stability. Various extracts, including those from Camellia sinensis, turmeric, grape seed, oregano, and Salvia officinalis, were used. Micromeritic properties, such as angle of repose, bulk density, and Hausner ratio, were assessed. The results revealed that the prepared polyhedral dispersible tablets were non-sticky and looked high-quality. The maximum weight variation obtained was 2.50%, which falls within the acceptable weight variation range, i.e., ±5%, hence passing the weight variation test. The hardness of prepared tablets was in the range of 2.94 to 3.02 kg/cm2, which falls within the limit of not < 3.0 kg/cm2. All the tablets showed a friability value at most 0.90%, which is less than the ideal limit, i.e., 1%. Formulation AP4 exhibited superior characteristics, with rapid disintegration time and stable drug release profile. Stability studies further validated the formulation's consistency under varying storage conditions. Preliminary phytochemical screening of the individual drugs and polyherbal formulation confirmed the presence of phytoconstituents such as flavonoids, alkaloids, carbohydrates, gums & mucilage, fats & fixed oils, steroids, glycosides, phenols, saponins but no volatile oils. The findings underscore the potential of polyherbal dispersible tablets as efficient delivery systems for medicinal herbs. Carr's index and Hauser’s ratio showed that the powder mixtures possess good flow properties. AP1 to AP9 were determined for the uniformity in weight, hardness, drug content and friability, which complied with the official requirements and the official limits mentioned in IP 2010.
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Ostrowski, Michał, Ewa Wilkowska, and Tomasz Bączek. "Impact of pharmaceutical dosage form on stability and dissolution of roxithromycin." Open Medicine 5, no. 1 (2010): 83–90. http://dx.doi.org/10.2478/s11536-009-0113-7.
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AbstractThe behavior of dispersible tablets containing enteric-coated pellets and oral suspension, both containing roxithromycin, was investigated using dissolution tests in different media. The dissolution test was performed under different pH conditions. For both dosage forms investigated, the test was conducted at pH 1.2, 4.5, and 6.8. Additionally, for dispersible tablets, the test involving increasing pH was performed at pH 1.2 (acid stage) and afterwards at pH 6.8 (buffer stage). The extent of dissolution was measured using high-performance liquid chromatography (HPLC). In all cases tested, roxithromycin underwent rapid degradation at pH 1.2. Dispersible tablets displayed the features of modified release preparations with a non-complete dissolution during the test times in all media. Conversely, the oral suspension behaved as an immediate release preparation, with degradation at pH 1.2. However, the dissolution of the oral suspension at pH 4.5 and 6.8 was rapid and complete. The role of enteric-coated pellets is to mask the bitter taste of the active substance upon administration. However, the coating showed lack of resistance to media at pH 1.2. Therefore, dispersible tablets containing enteric-coated pellets are not pharmaceutically equivalent to the immediate-release oral suspension.
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Akshay Kumar S, Gowda D V, Sharadha M, and Akhila A R. "The insights on Oro-dispersible tablet." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 260–73. http://dx.doi.org/10.26452/ijrps.v11i1.1815.
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Orodispersible tablets (ODTs) were the conventional product that disintegrates or dissolves into the buccal mucosa in less than 1mins in the absence of water and without chewing. They were first acquainted with the market during the 1980s, and end up one of the quickest developing subdivisions of the oral medication conveyance industry and their items are creating at an extraordinary rate. New orodispersible tablet innovations address numerous pharmaceutical and need of patients, extending from upgraded life-cycle the executives for reasonable medicating for pediatric, aged, and mental patients with trouble in swallowing. These supposedly affect about 35% of the all-inclusive community and related to various ailments like Parkinsonism, mental incapacity, motion sickness, obviousness, water inaccessibility, and so on. Other individuals possibly will face difficulties by utilizing control release solid oral product comprise the psychologically ill, partially developed patients, and rare patients those are unco-operative, on taking place diminished fluid consumption and are nauseated. To defeat such troubles, orodispersible tablets have been formulated. In this dosage form, the property of ODTs can be reached by the expansion of various additives such are super- the disintegrating agent is the main excipient. This has been motivated by both industry and academia to develop advanced orally dispersible products and advanced methodologies in the market. The ODTs are the most extensively implemented marketable products than others. The main purpose of this review paper is to provide the complete information of ODTs formulation
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R, Yogaraj, Surinder Kaur, and Padmaa M. Paarakh. "A Brief Introduction on Oro Dispersible Tablets." April-May 2023, no. 33 (April 10, 2023): 9–16. http://dx.doi.org/10.55529/jcpp.33.9.16.
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Oro dispersible tablets (ODTs), which have improved solubility and stability over the past three decades, have drawn a lot of interest as a superior alternative to traditional tablets and capsules. ODTs—solid dosage forms with medications that dissolve on the tongue fast, usually in a few seconds. New ODT technologies answer a wide range of pharmaceutical preparations and patient needs, to enhance the lifecycle management to straightforward dosage regimen for dysphagic, children, old, and mentally imbalanced patients. Methods for administering orally dispersible drugs are frequently used to improve patient compliance and bioavailability. Researchers in academia and business have been motivated by this to create novel technologies and orally disintegrating formulations in this field. This article's main objective was to cover the development of ODTs, formulation concerns, novel oral dispersible technology, different types of methodology to evaluate, the selection of drug candidates, and novel possibilities in future.
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M., Anusha, Varun Raj S., Krishna Srewe P.V., Divya Deepthi N., Evanjiline Ch., and Roopa Koteswari Ch. "Formulation and Development of Rosuvastatin Fast Dissloving Tablets using Natural Super Disintegrates." Research & Review: Drugs and Drugs Development 1, no. 2 (2019): 61–77. https://doi.org/10.5281/zenodo.3271091.
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<em>Rosuvastatin is in category of the drug class. It is used to treat high cholesterol and to block cardiovascular disease. The main aim of this study is to develop oral dispersible tablets of Rosuvastatin using different types of super disintegrates to enhance the disintegration and dissolution of Rosuvastatin to improve bioavailability of the drug. Many trials were made to prepare a satisfactory rosuvastatin oral dispersible tablet using direct compression and wet granulation method. Formulate tablets were examine with different parameters such as weight variation, hardness, friability, wetting time, in vitro disintegration time, drug content, water absorption ratio and in vitro drug release. Formulas prepared by direct compression showed good flowability, while formulas were prepared by wet granulation showed with very poor flow properties. Numerous super disintegrates were used such as cross carmellose (CCS), sodium starch glycolate (SSG) and cross povidone (CP), then latter found to be the best in term of showing the fastest disintegration time. Among the two-diluents mannitol was found to be the best one in preparing rosuvastatin tablet with fastest disintegration time in mouth. The optimized selected formula (F11) was prepared by using 15% w/w cross povidone, by direct compression resulted that the shortest disintegration time in mouth (11 seconds), superior drug release profile [the time required for 80% of the drug to be released (t80%) and percent drug dissolved in 2 min (D2min) were 6 min. and 56 %respectively]. In addition to that the selected formula had shown acceptable hardness and friability, hence it is selected as the best formula. The overall results showed that cross povidone was the best super disintegrate of showing the shortest disintegration time while mannitol was the best diluent in preparing Rosuvastatin oral dispersible tablet and this suggested the possibility of utilizing the selected best formula (F11) in the preparation of Rosuvastatin oral dispersible tablet as a new dosage form for oral administration.</em>
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Yavagal, K., B. U. Bolmal, and A. P. Gadad. "FORMULATION AND OPTIMIZATION OF CEFIXIME TRIHYDRATE DISPERSIBLE TABLETS BY DIRECT COMPRESSION TECHNIQUE." INDIAN DRUGS 52, no. 07 (2015): 36–38. http://dx.doi.org/10.53879/id.52.07.10347.
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The optimized formulation of cefixime dispersible tablets were developed using super disintegrants sodium starch glycolate and crospovidone. D-optimal design is used to optimize the formulation of cefixime dispersible tablet to study the effective concentration of independent variables SSG, crospovidone and MCC on responses (dependent variables) i.e. dispersion time, % drug release and % friability. Twelve formulations were prepared and evaluation of pre-compression and post compression parameters of tablets was perfomed. Analysis of variance (ANOVA) probability (p) < 0.05 for responses was found to be significant. A response surface plot is also presented graphically to represent the effect of the independent variables on the dispersion time, % friability and % drug release. Finally, a checkpoint batch is prepared to prove the validity of evolved method. The stability studies of the optimized formulation F13 were carried as per ICH guidelines proved that the optimized formulation was stable even after 2 months.
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M. G., Mowafaq. "Development and evaluation of or dispersible tablet of Propranolol Hydrochloride by sublimation technique." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 2 (2013): 65–72. http://dx.doi.org/10.32947/ajps.v13i2.202.
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Propranolol Hydrochloride (PHCl) is a synthetic beta adrenergic receptor blockingagent used widely in the treatment of angina pectoris, cardiac arrhythmias and hypertension.The purpose of this study was to develop PHCl orodispersible tablet of fast disintegration inmouth with high mechanical strength to withstand handling during manufacturing and patientuse.Sublimation technique was used to prepare the orodispersible tablets of PHCl using foursubliming agents; camphor, thymol, ammonium bicarbonate and menthol by directcompression method in presence of 2.5%w/w crospovidone as superdisintegrant. The product isof high porosity after sublimation of agent from the tablets. To mask the bitter taste of the drug,increase sweetness and to provide acceptable feeling in mouth, aspartame, saccharin sodium, and citric acid were added. Mannitol was used as sugar based multifunctional diluents. The formulas powder blend was evaluated before compression for angle of repose and compressibility index while the post-compression parameters were evaluated for weight variation, content uniformity, hardness, friability, disintegration time, and drug in vitro release of the formulated tablets. The weight and drug content of tablets of all batches were within the acceptable limits. The in vitro disintegration time was less than 62.8 seconds for all batches except that containing 2.5% w/w menthol shows disintegration in 202.73 sec.Menthol 15% w/w shows the shortest disintegration time among subliming agents with acceptable friability and hardness, thus selected as the best formula (F9). The optimized formulation showed faster release profile in comparison to the conventional tablets.
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Khan, Sohail, Dr Farya Zafar, Dr Huma Ali, et al. "WATER DISPERSIBLE TABLETS; FEATURES AND DEVELOPMENTAL CHALLENGES." PROFESSIONAL MEDICAL JOURNAL 23, no. 09 (2016): 1022–25. http://dx.doi.org/10.17957/tpmj/16.3412.
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KONG, Bin, XinXia LI, YongXiang GAN, XinWen QI, and WenJun LI. "Investigation on the dissolubility of bezafibrate tablets and bezafibrate dispersible tablets." Pharmaceutical Care and Research 16, no. 3 (2016): 230–33. http://dx.doi.org/10.5428/pcar20160319.
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Samran, Samran, and Hari Ronaldo Tanjung. "Metoclopramide-OROS Dispersible Tablets Optimized Formula Bioavailability Study." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 338–41. http://dx.doi.org/10.3889/oamjms.2020.3353.
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BACKGROUND: Bioavailability and bioequivalence studies required by regulations to ensure therapeutic equivalence between a pharmaceutically equivalent test product and a reference product.
 AIM: This study aimed to evaluate the bioavailability performance between the optimum formula of OROS dispersible tablet-metoclopramide dosage forms (FCL-6) and the Primperan® as the reference product.
 METHODS: The FCL-6 formula was design by simplex lattice design model with a three components mixture of excipients: Solid tapai extract, corn starch, and Avicel. The optimum formula of OROS dispersible tablet (ODT)-metoclopramide consists of solid tapai extract (27.038 mg), corn starch (27.407 mg), and Avicel (53.555 mg), metoclopramide hydrochloric acid (HCl) (10.00 mg), LH-11 (22.50 mg), aspartame (5.00 mg), talcum BP (3.00 mg), and Mg stearate (1.50 mg). The in vivo test was done by cross-over design method using six rabbits. The level of metoclopramide concentration from in vivo test was measured by high-performance liquid chromatography instrument.
 RESULTS: The study revealed that the tmax, Cmax, and area under curve (AUC) of ODT-metoclopramide FCL-6 were 60 min, 1.95 ± 0.13 μg/mL, and 1118.20 ± 150 μg/mL. min consecutively. The Cmax and the concentration of the drug absorbed in the blood (AUC) of ODT-metoclopramide were larger than Primperan® tablets. Statistical data of the optimized ODT-metoclopramide compared with Primperan® showed that the Cmax and AUC significance values were <0.05 (p < 0.05).
 CONCLUSION: The optimized formula of ODT-metoclopramide revealed a better characteristic of Cmax and AUC concentration compared with Primperan®. The optimized ODT-metoclopramide with tapai extract was found to be promising to improved bioavailability of metoclopramide.
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A., Deevan Paul* P. Nagaraj E. Reshma T. Mahesh Y. Divyasree. "CHALLENGES IN NANOTECHNOLOGY DRUG DELIVERY SYSTEMS - STATE OF ART TECHNOLOGIES." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1550–58. https://doi.org/10.5281/zenodo.816203.
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The potential challenges to solve the poor solubility, limited chemical stability in vitro and in vivo after administration (i.e. short half-life), poor bioavailability and potentially strong side effects requiring drug enrichment at the site of action (targeting). This review describes the use of nanoparticulate carriers, developed in our research group, as one solution to overcome the dosage forms. The performance of ODTs depends on the technology used in their manufacture. The orally disintegrating property of these tablets is attributable to the quick ingress of water into the tablet matrix, which creates porous structure and results in rapid disintegration. Hence, the basic approaches to develop ODTs include maximizing the porous structure of the tablet matrix, incorporating the appropriate disintegrating agent and using highly water-soluble excipients in the formulation. Fast disintegrating tablets have better patient acceptance, compliance and possibly will tender enhanced biopharmaceutical properties, superior efficacy, and enhanced safety compared to conventional oral dosage forms. The perspective for such dosage forms is promising because of the accessibility of new technologies combined with strong market/patient acceptance. Keywords: Oro dispersible tablets, Bioavailability, Conventional films, Disintegrating time.
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Nevle, Shyamkant S., and Santosh R. Butle. "Formulation Development and Evaluation of Taste-masked Moxifloxacin Dispersible Tablets for the Treatment of Pediatric Tuberculosis." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 02 (2023): 169–75. http://dx.doi.org/10.25004/ijpsdr.2023.150208.
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Moxifloxacin (MOX) is a fluoroquinolone antibiotic, a second-line anti-TB drug widely used in the treatment of multidrug-resistant tuberculosis (MDR TB) and drug-susceptible TB. MOX have taste and smell issues with low patient compliance, especially in the pediatric population. MOX taste-masked dispersible tablets were developed by direct compression method using mannitol, aspartame as a sweetening agent and lemon flavor as a flavoring agent. The prepared granules were evaluated for flow properties and compressed tablets for hardness, friability, content uniformity, weight variation, DT and in-vitro drug release. Instrumental analysis like FTIR, DSC and XRD was also performed. The flow properties of the granules of batch F6 were found to be excellent based on the results obtained. The weight variation and content uniformity of the tablets was found to be excellent F6 due to the excellent flow properties of the granules. All of the tablets in the study disintegrated between 22 (F6) to 135 seconds (F1), meeting the official requirement (3 minute) for dispersible tablets. The optimized batch showed complete drug release within 10 minutes time period. The FTIR and DSC study found no incompatibility between the drug excipients. The MOX in the final formulation was present in crystalline form, as shown by XRD. The dispersible MOX tablets could be a better option for treating pediatric TB.
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Karpishchenko, Sergey A., Marina А. Ryabova, Olga M. Kolesnikova, and Mikhail Yu Ulupov. "Antibacterial therapy for acute streptococcal tonsillopharyngitis: results of a randomized comparative clinical trial with amoxicillin + clavulanic acid EXPRESS." Terapevticheskii arkhiv 96, no. 3 (2024): 273–79. http://dx.doi.org/10.26442/00403660.2024.03.202653.
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Background. Acute tonsillopharyngitis is one of the most common types of respiratory tract infections. In case of bacterial etiologies of the disease, penicillin antibiotics are prescribed, in particular amoxicillin + clavulanic acid. Dispersible forms of antibiotics have a number of advantages over film-coated tablets and are characterized by better pharmacokinetic parameters that increase the effectiveness and safety of treatment, as well as patient compliance.
 Aim. To compare the effectiveness and safety of Amoxicillin + Clavulanic acid EXPRESS in the form of dispersible tablets and amoxicillin with clavulanic acid in film-coated tablets in the treatment of acute streptococcal tonsillopharyngitis.
 Materials and methods. A randomized comparative clinical study involved 60 adult patients diagnosed with acute streptococcal tonsillopharyngitis. Group 1 (n=30) received the Amoxicillin + Clavulanic acid EXPRESS, dispersible tablets, 875+125 mg 2 times a day at the beginning of meals. Group 2 (n=30) received Amoxiclav, film-coated tablets, 875+125 mg 2 times a day at the beginning of meals. The duration of the treatment was 10 days. The following procedures were performed to all participants: general clinical and otorhinolaryngological examinations, an express test to detect group A streptococcal antigens in a smear from the posterior pharyngeal wall (streptatest), assessment of symptoms of acute tonsillopharyngitis on the McIsaac scale, severity of sore throat, difficulty swallowing, swelling of the throat, measurement of body temperature, assessment of the clinical global impression of the therapy, adherence to treatment, frequency of the adverse reactions before treatment, 3 days after the beginning of therapy and after the course completion (day 10).
 Results. Recovery occurred in 96.6% of patients in group 1 according to examination on the 10th day of treatment and in 93.3% of patients in group 2. The rate of fever regression was higher in group 1 – on the 3rd day of treatment, normalization of temperature was observed in 36.6% and 30% of patients in the comparison group. Pain syndrome, symptoms of throat swelling and difficulty swallowing significantly (p0.01) regressed by the 10th day in patients of both treatment groups. The incidence of adverse reactions on the 10th day of treatment in group 1 was 10%, in group 2 – 33.3% (p=0.03).
 Conclusion. Amoxicillin + Clavulanic acid EXPRESS has high therapeutic efficacy in the treatment of acute streptococcal tonsillopharyngitis, comparable to the Amoxiclav in film-coated tablets. At the same time, dispersible tablets of Amoxicillin + Clavulanic acid EXPRESS demonstrated a significantly higher safety profile compared to the simple tablet form.
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Baliga, S. B., B. P. Manjula, and M. Geetha. "FORMULATION AND EVALUATION OF MICROSPHERE BASED ORO DISPERSIBLE TABLETS OF SUMATRIPTAN SUCCINATE." INDIAN DRUGS 54, no. 03 (2017): 28–38. http://dx.doi.org/10.53879/id.54.03.10794.
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Sumatriptan succinate (SS) is a drug used in the treatment of migraine headaches, but suffers from low patient compliance due to its unpalatable bitter taste. The purpose of the present work was to prepare taste-masked oro dispersible tablets (ODTs) of SS by incorporating drug loaded microspheres into tablets for use in patients experiencing difficulty in swallowing. Microspheres loaded with SS were prepared by solvent evaporation technique. Eudragit EPO, a pH-sensitive aminoalkylmethacrylate copolymer, was used for coating the drug particles, acetone as solvent for the polymer and light liquid paraffin as an encapsulating medium. Drug : polymer ratio of 1:1 was considered to be optimized formulation with a yield of 99.96%, entrapment efficiency of 61.55%, particle size ranging from 30.32 – 90.96μm and in vitro drug release of 85.06% within an hour. FTIR studies suggested absence of drug-excipient interaction. Tablets prepared by direct compression containing microspheres and effervescent agents were evaluated for pre-compression and post-compression parameters. The wetting time, in vitro dispersion time and in vitro disintegration time of the tablets were found to be 39 sec, 35 sec and 32 sec, respectively. The drug release from the tablet was about 85.44% within an hour. The SEM of final ODTs revealed that the microspheres remained intact even after compression. Stability studies indicated that the selected formulation was stable. The results obtained suggested that effective taste-masking was achieved for SS using the technique of microencapsulation and ODTs of acceptable characteristics were obtained by adding effervescent agents followed by direct compression.
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Fraser, Jacqueline, Rowena Brook, Tony He, and Diana Lewis. "Deferasirox-induced liver injury and Fanconi syndrome in a beta-thalassemia major male." BMJ Case Reports 13, no. 7 (2020): e234542. http://dx.doi.org/10.1136/bcr-2020-234542.
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A 33-year-old male presenting with subacute abdominal pain was found to have hyperbilirubinaemia, hypokalaemia and hyponatraemia. This was in the setting of transitioning between deferasirox iron chelator formulations, from dispersible tablets to film-coated tablets for ongoing treatment of chronic iron overload secondary to transfusion requirement for beta-thalassemia major. A liver biopsy demonstrated acute cholestasis with patchy confluent hepatocellular necrosis and mild to moderate microvesicular steatosis. Based on the histological, biochemical and clinical findings, the diagnosis of hepatotoxicity and Fanconi-like syndrome was made. The patient improved clinically and biochemically with cessation of the deferasirox film-coated tablets and supportive management. To our knowledge, this is the first case report of hepatotoxicity and Fanconi-like syndrome occurring due to deferasirox film-coated tablets with previous tolerance of dispersible deferasirox tablets. It is important to raise clinical awareness of this potentially severe complication.
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Reddy, P. Srikanth, V. Alagarsamy, P. Subhash Chandra Bose, V. Sruthi, and D. Saritha. "DESIGN AND CHARACTERIZATION OF NATEGLINIDE ORAL DISPERSIBLE TABLETS BY SOLID DISPERSION TECHNIQUE." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (2022): 72–77. http://dx.doi.org/10.7897/2277-4343.130491.
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An ideal dosage regimen in the drug therapy of any disease is the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment. The main objective of the present work is to investigate the possibility of obtaining an immediate release tablet of Nateglinide with improved dissolution using the Solid dispersion technique. Solid dispersions preparations containing different weight ratios of Nateglinide in PEG6000 (1:1, 1:3, 1:5) were prepared by the melting method and characterized for drug content, phase solubility study, and dissolution study. Immediate release tablets were prepared using various polymers, and the prepared tablets were evaluated for weight variation, friability, assay, hardness, thickness, disintegration test and dissolution test. The Nateglinide immediate release tablet (F2) showed 58.72% drug release within the first 5 min. and 99.50% drug release within 30 min. The results showed that the formulation satisfied the objective of fast disintegration, dissolution, % friability, hardness, wetting time, water absorption ratio, ease of administration and safety. The success of the present study recommends a detailed investigation into in-vivo studies for its effective use in clinical practice.
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Goncharov, A. S., A. Grigoriev, A. Globenko, et al. "Investigation of pharmacokinetics and drug-drug interactions of melatonin and memantine as components of the new original combination drug Miladean®." Clinical pharmacology and therapy 37, no. 2 (2023): 59–65. http://dx.doi.org/10.32756/0869-5490-2023-2-59-65.
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To compare pharmacokinetics and evaluate drug-drug interactions of the studied drug Miladean® oral dispersible tablets 3 mg + 5 mg (JSC Valenta Pharm, Russia) and reference products Akatinol Memantine 10 mg film-coated tablets (Merz Pharma GmbH & Co. KGaA, Germany) and Melaxen 3 mg film-coated tablets (Unipharm Inc., USA).
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P. Samba Siva Rao, P. Samba Siva Rao, Dr G. Nagaraju Dr. G. Nagaraju, A. Sanjay A. Sanjay, et al. "Review on Formulation and Evaluation of Voglibose Mouth Dissolving Tablets." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 309–17. https://doi.org/10.35629/4494-1002309317.
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Mouth dissolving tablets are solid dosage forms which break down in the oral cavity less than one minute without using of water. These dosage forms are placed in the mouth, allowable to diffuse or melt in the saliva. The purpose of this article is to review potential advancements of Oral Dispersible Tablet technology in drug delivery applications. Mouth dissolving Voglibose tablets offer a convenient and patient-friendly alternative to traditional tablets for the management of type 2 diabetes mellitus. With their rapid disintegration and absorption, these tablets provide a quick and effective way to control postprandial blood glucose levels. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The blend was evaluated for angle of repose, bulk density, tapped density, Carr‟s index, Hausner‟s ratio and IR studies. The tablets were evaluated for hardness, friability, weight variation, content uniformity test, disintegration test, wetting time.
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Prajapat, Abhishek, Akash Yadav, and Dinesh Kumar Jain. "An Overview of Natural Disintegrating Agent Used in Dispersible Tablets." Asian Pacific Journal of Health Sciences 10, no. 2 (2023): 47–54. http://dx.doi.org/10.21276/apjhs.2023.10.2.12.
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The oral therapy is the most commonly used method for administering many medications since it is thought to be the safest, most practical, and least expensive method. Fast dissolving pills are highly popular right now because they dissolve or easily dissolve in the mouth after administration without the need for water. Fast dissolving tablets have been developed to address the drawbacks of conventional dose forms, particularly dysphagia (refers to problem in which it becomes difficult to swallow), in pediatric and geriatric patients. Natural materials offer an advantage in comparison to the synthetic ones since they are more easily accessible, cost effective, not harmful, and chemically inert. By acting as a binder, diluent, and superdisintegrant, natural polymers such as locust bean gum, banana powder, mango peel pectin, Mangifera indica gum, and Hibiscus rosa-sinensis mucilage improve tablet properties, increase the solubility of drugs which are insoluble or poorly soluble, helps in reducing the disintegration time, and aid as nutritional supplements. Natural polymer is derived from natural source, are economical, not harmful, decomposable, and environmentally helpful, free of negative effects, restorable, and serve as nutritional supplements. Studies have shown that natural polymers are more effective and safer than manufactured polymers. The aim of the current article is to study and examine natural polymers which have been approved by Food and Drug Administration for use in quick dissolving tablets.
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Hong, Xiaoxuan, Xiaolu Han, Xianfu Li, Jiale Li, Zengming Wang, and Aiping Zheng. "Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures." Pharmaceutics 13, no. 11 (2021): 1780. http://dx.doi.org/10.3390/pharmaceutics13111780.
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Three-dimensional (3D) printing is an emerging technology that has high application potential for individualized medicines and complex solid dosage forms. This study is designed to explore binder jet 3D printing (BJ-3DP) for the development of high-precision and repeatable compound levetiracetam-pyridoxine hydrochloride (LEV-PN) multicompartmental structure dispersible tablets. PN was dissolved in printing ink directly and accurately jetted into the middle, nested layer of the tablet, and precise control of the drug dose was achieved through the design of printing layers. With modification of the drying method, the “coffee ring” effect caused by drug migration during the curing and molding of the tablets was overcome. Furthermore, 3D topography showed that the tablets have a promising surface morphology. Scanning electron microscopy and porosity results indicated that the tablets have a loose interior and tight exterior, which would ensure good mechanical properties while enabling the tablet to disintegrate quickly in the mouth and achieve rapid release of the two drugs. This study used BJ-3DP technology to prepare personalized multicompartmental structures of drug systems and provides a basis for the development of complex preparations.
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Niu, Ben, and Lan Li. "Study on the Clinical Efficacy of Megestrol Acetate Dispersible Tablets in Adjuvant Treatment of Acute Leukemia." Journal of Clinical and Nursing Research 7, no. 4 (2023): 194–97. http://dx.doi.org/10.26689/jcnr.v7i4.5154.
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Objective: To analyze the clinical efficacy of megestrol acetate dispersible tablets in the adjuvant treatment of acute leukemia. Methods: 80 patients with acute leukemia admitted from December 2021 to December 2022 were randomly divided into two groups. The control group underwent chemotherapy, and the observation group took megestrol acetate dispersible tablets and underwent chemotherapy. The effect of the treatments were evaluated by analyzing the albumin (Alb) and prealbumin (Palb) indicators, and the adverse reactions were observed. Results: There was no significant difference in Alb and Palb indexes between the two groups before treatment (P > 0.05). After treatment, Alb and Palb indexes in the observation group were greater than those in the control group (P < 0.05). The incidence of adverse reactions in the control group was 20.00%, which was significantly higher than the observation group (5.00%), with P < 0.05. Conclusion: The combination of megestrol acetate dispersible tablets and chemotherapy is more effective in treating patients with acute leukemia, and the Alb and Palb indexes can be optimized. Besides, there are fewer adverse reactions, which means that the treatment is relatively safe.
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Seal, Rupam, and Dr Soundrapandian Chidambaram. "A Comprehensive Review on Progress and Challenges in Technology of Orodispersible Tablets." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 475–83. https://doi.org/10.35629/4494-0906475483.
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Numerous medications that absorb through the buccal cavity have been explored in connection to orodispersible tablet dosage forms because of their many benefits, which include stability, fast onset of action, water-free administration, precise dosing, ease of production, better bioavailability, compact packaging, and easy handling (1–5). Conventional Oro dispersible tablets have been linked to drawbacks such a lack of mechanical strength, an inclination for sugar, and the absence of an option for regulated or delayed release, if not cooked properly, an unpleasant flavor and grittiness on the tongue (5–8). Oro dispersible tablets are solid dose forms that dissolve quickly in saliva and are not likely to cause drowsiness or a delayed start to action.(8–10) They have been researched to increase bioavailability with the goal of either increased compliance effects or a quick onset of action.(11–14) In order to obtain successful outcomes, precise and intricate manufacturing and characterization processes must be taken into account throughout the design and development of innovative Orodispersible drug delivery systems.
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J., Nandhini, and Rajalakshmi A. N. "Formulation development and evaluation of methylprednisolone dispersible tablets." Asian Journal of Pharmacy and Pharmacology 4, no. 4 (2018): 514–21. http://dx.doi.org/10.31024/ajpp.2018.4.4.20.
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