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Dissertations / Theses on the topic 'Dissociation constant of inhibitor'

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Published: 4 June 2021

Last updated: 20 February 2023

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1

Mann, Maretta Clare, and n/a. "Sialylmimetics as Potential Inhibitors fo Vibrio Cholerae Sialidase." Griffith University. Institute for Glycomics, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20061006.083947.

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Cholera is an epidemic infectious diarrhoeal disease that for centuries has proven its frightening ability to cause rapid and widespread loss of human life. All symptoms associated with cholera are a result of rapid dehydration due to infection by pathogenic strains of the bacterium Vibrio cholerae. The damaging effects associated with cholera are mainly attributed to the toxin, which is secreted by the bacterium and infects cells lining the gastrointestinal tract. A sialidase, also secreted by the bacterium, is believed to facilitate toxin uptake by the gastrointestinal epithelium. V. cholera

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Mann, Maretta Clare. "Sialylmimetics as Potential Inhibitors fo Vibrio Cholerae Sialidase." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367187.

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Cholera is an epidemic infectious diarrhoeal disease that for centuries has proven its frightening ability to cause rapid and widespread loss of human life. All symptoms associated with cholera are a result of rapid dehydration due to infection by pathogenic strains of the bacterium Vibrio cholerae. The damaging effects associated with cholera are mainly attributed to the toxin, which is secreted by the bacterium and infects cells lining the gastrointestinal tract. A sialidase, also secreted by the bacterium, is believed to facilitate toxin uptake by the gastrointestinal epithelium. V. cholera

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3

Sooväli, Lilli. "Spectrophotometric measurements and their uncertainty in chemical analysis and dissociation constant measurements /." Online version, 2006. http://dspace.utlib.ee/dspace/bitstream/10062/627/5/soovalililli.pdf.

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4

Ronneburg, Henrike [Verfasser], Jürgen [Akademischer Betreuer] Dittmer, and Kurt [Akademischer Betreuer] Engeland. "Prognostische Relevanz von Rho-GDP dissociation inhibitor Proteinen beim Mammakarzinom / Henrike Ronneburg. Betreuer: Jürgen Dittmer ; Kurt Engeland." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024895807/34.

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5

Evangelista, Jaqueline Pesciutti. "Selenoproteínas: Seril-tRNA Sintetase e as selenoproteínas do Trypanosoma brucei." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-13112014-171709/.

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O aminoácido selenocisteína (Sec) representa a principal forma biológica de selênio sendo requerida uma complexa maquinaria molecular para sua síntese e incorporação co-traducional em selenoproteínas. A Seril-tRNA sintetase (SerRS) inicia essa via, aminoacilando o Ser-tRNASec (SelC) com uma serina e também aminoacila os tRNAsSer. Sendo assim, um dos focos deste trabalho foi estudar a interação da SerRS de Trypanosoma brucei (T. brucei) com os tRNAsSer e o SelC utilizando a técnica de anisotropia de fluorescência para determinar suas constantes de dissociação. Em Kinetoplastidae, além da via de

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6

Karbanová, Kateřina. "Disociační chování přírodních biokoloidů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316163.

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This diploma thesis is focused on the study of dissociation behaviour of natural biocolloids, namely humic acids and fulvic acids. Humic and fulvic acids are natural, heterogeneous, high molecular weight substances which behave as weakly acidic polyelectrolytes and they have complex not exactly described structure. They are formed by biochemical transformations of organic residues (mainly plants). They are part of the soil, water, peat, sediments and coal. Solubility of humic acids is affected by pH value. The higher the pH value is the higher the solubility is. Fulvic acids are soluble in who

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7

Viktorinová, Jana. "Využití chronopotenciometrické titrace v huminovém výzkumu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2013. http://www.nusl.cz/ntk/nusl-216933.

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Humic acids are natural substances belonging to the group of humic substances. They arise mainly decomposition of plant residues. They are contained in soils, peat, sediments, young coal, water and even in the air. Humic acids are only partially soluble in water with increasing pH increases their solubility. Diploma thesis focuses on the use of chronopotentiometric titration of humic research. This method is mainly used for the determination of trace concentrations of analytes. This work is focused on the determination of acidity by potentiometric titration and the determination of dissociatio

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8

Chaudhury, Chaity. "Identification and biochemical characterization of a novel receptor:ligand interaction between FcRn and albumin." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1110211148.

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9

Smallman, Matthew John. "Spatial regulation of Rho GTPase signalling during root hair development in Arabidopsis thaliana is reliant upon the guanine nucleotide dissociation inhibitor SCN1." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496221.

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The scn1-1 mutants of Arabidopsis are characterised by spatially deregulated sites of root hair growth. This studydemonstrates that this phenotype is the result of the loss of regulation of members of the plant specific sub-family of Rho small GTPases by the Guanine nucleotide Dissociation Inhibitor (GDI), encoded by SCN1. The small GTPases R0P2, R0P4 and R0P5 of Arabidopsis are members of the I subset of type I ROPs that terminate with a conserved CXXL box and undergo 3 prenylation. These small GTPases are expressed in trichoblasts, and localize in patters suggestive of specific roles through

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10

Li, Muchen. "Determination of dissociation constant of DNA/DNA hybridization by three different surface techniques : comparison of surface plasmon resonance, fluorescent microarray and evanescent field fluorescence." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEC028/document.

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Les biocapteurs sont des outils de détection et d'analyse puissants qui ont été largement utilisés dans les domaines de la santé, de la recherche biomédicale et de l’environnement. Cependant, différents biocapteurs utilisent différents transducteurs qui varient par la nature des substrats utilisés et par la chimie de surface. Tous ces paramètres peuvent avoir un effet sur les réactions biomoléculaires aux interfaces et conduire à des variations de la mesure de la constante de dissociation Kd. Dans ce contexte, ce travail de thèse visait à comparer trois techniques différentes : biopuce avec un

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11

Truttmann, Anita Carmen. "Apparent MG[hoch]2plus-Adenosine 5-Triphosphate dissociation constant measured with Mg[hoch]2plus-Macroelectrodes under conditions pertinent ot [hoch]31P NMR ionized magnesium determinations /." [S.l.] : [s.n.], 1997. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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12

MEDA, PHILIPPE. "Etude de la liaison de la tubuline au centrosome." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10189.

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Le centrosome est le centre majeur d'organisation des microtubules dans les cellules eucaryotes. Le mecanisme de nucleation de la tubuline sur le centrosome est encore mal compris, bien que le modele le plus probable implique une liaison initiale des dimeres de la tubuline sur le centrosome. Ce travail demontre que la liaison tubuline-centrosome est specifique et que le centrosome possede en moyenne 25. 000 sites de liaison, avec une constante de dissociation (kd) d'environ 5,5 micromolaires. Une banque de peptides de tubuline produite par digestions endoproteasiques a ete utilisee, avec d'aut

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13

Annala, Suvi Katariina [Verfasser]. "FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq : mechanism of action and relevance for treating Gq-driven cancers / Suvi Katariina Annala." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1194464807/34.

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14

Martins, Nádia Helena. "Ensaios enzimáticos de proteases de HIV-1 de subtipos brasileiros." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-27042008-122417/.

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Mesmo com o grande número de estudos relacionados à proteases do subtipo B e de como suas mutações podem interferir na estrutura, na resistência a inibidores e na eficiência catalítica da enzima, existe ainda uma lacuna de como as mudanças polimórficas de proteases de HIV de outros subtipos de HIV-1 interferem nesses fatores. Nesse contexto insere-se esse trabalho, que utilizou proteases de HIV-1 isoladas de pacientes brasileiros HIV-1 infectados com o subtipo F, e outros dois mutantes, sendo que um do subtipo F e outro do subtipo B para ensaios frente a seis inibidores comercialmente disponív

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15

Obame, Nkoghe Germain. "Synthèse et étude cinétique de l'homolyse de biomolécules utilisables comme agents théranostiques." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4367.

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Ce travail est présenté en 2 parties. La première partie aborde la synthèse stéréocontrôlée de 2 séries de carbonucléosides de structures méthylènecyclopropane. Les molécules cibles sont des analogues de l’entécavir, une prodrogue utilisée en trithérapie pour lutter contre le VHB. Les synthèses des carbonucléosides cibles de la série I utilisent un chiron commun, un alcool obtenu par désymétrisation enzymatique d’un diol méso. La transformation chimique de cet intermédiaire clé permet d’obtenir le carbonucléoside (+)-17 en 8 étapes mettant en œuvre comme étapes cruciales un réarrangement de Cu

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16

Le, Bonniec Bernard. "Contribution à l'études des sérine protéases de la coagulation et de la fibrinolyse." Paris 6, 1986. http://www.theses.fr/1986PA066414.

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17

Suchá, Šárka. "Studium acidobazických a elektrolytických vlastností hyaluronanu v roztoku." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2015. http://www.nusl.cz/ntk/nusl-217088.

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This diploma thesis deals with acid-base and electrolytic behavior of hyaluronan solutions at different ionic strength. Acid-base behavior of hyaluronan was investigated by acid-base titrations which were carried out with two different methods, acid and alkaline acid-base titration. Dissociation constants at different ionic strength at zero degree of dissociation and at 50% degree of dissociation were evaluated from the results of acid-base titrations. Dissociation constants obtained from acid acid-base titrations have values between 3,0 and 3,6. Dissociation constants obtained from alkaline a

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18

Mahé-Gouhier, Nicole. "Etude des interactions lipase/colipase par chromatographie d'affinite conventionnelle (cac) et haute performance (cahp)." Paris 7, 1987. http://www.theses.fr/1987PA077062.

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Cette these repose sur l'application de la chromatographie d'affinite (zonale) conventionnelle (cac) et haute performance (cahp) a l'etude des interactions de la lipase (ou ses isolipases, ou sa sequence c terminale) d'une part, et la colipase, d'autre part. Les constantes de dissociations k::(d) du complexe calculees en cac et cahp sont voisines des valeurs mesurees par d'autres techniques non chromatographiques dans des conditions operatoires similaires. La cahp est une technique qui permet de determiner rapidement la stabilite du complexe lipase/colipase. L'influence de parametres physiques

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19

Pavanelli, Jéssyca Cristine. "Modularidade gênica das famílias da dissulfeto isomerase proteica e do inibidor da dissociação de guanina: estudos computacionais, moleculares e funcionais." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-06022017-153111/.

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Vias redox são importantes reguladores da homeostase e sinalização celular, mas o entendimento dos mecanismos desses processos é incompleto. Tiol-proteínas como a dissulfeto isomerase proteica (PDI) podem ser moduladores dessas vias. A PDI(PDIA1) é o protótipo da família das PDIs, cuja função canônica é o enovelamento redox de proteínas no retículo endoplasmático. Além disso, PDI exerce regulação de NADPH oxidases, as principais fontes de oxidantes celulares, e é necessária para ativação de RhoGTPases, organização do citoesqueleto e migração de células vasculares. No estudo de mecanismos pelos

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20

Adamczyk, Katrin. "Ultrafast charge transfer processes in solution." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16202.

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Die Reaktionspfade und Reaktionsdynamik photoinduzierter bimolekularer Ladungstransferreaktionen werden mit Hilfe der ultraschnellen polarisationsabhängigen UV-Pump/IR-Probe-Spektroskopie charakterisiert. Allgemein akzeptierte Modelle zur Beschreibung von bimolekularen Elektrontranserreaktionen nehmen an, dass Ladungstrennung in polaren Lösungsmitteln zu zwei Arten von Ionenpaaren führt, den lockeren (LIPs) und den engen Ionenpaaren (TIPs). TIPs und LIPs können durch die Beobachtung von Schwingungsmoden spektroskopisch unterschieden werden. Allerdings deuten die multiplen Zeitskalen sowohl für

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21

Norberg, Daniel. "Quantum Chemical Studies of Radical Cation Rearrangement, Radical Carbonylation, and Homolytic Substitution Reactions." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8178.

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22

Debord, Jean. "Relation structure chimique-activité biologique pour quelques phosphoramides et benzamides." Poitiers, 1988. http://www.theses.fr/1988POIT2331.

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Les constantes d'inhibition reversible de la butylcholinesterase par une serie de 16 phosphoramides aliphatiques ont ete determinees par spectrophotometrie et par microcalorimetrie. L'activite des substituants amines augmente avec la lipophilie. L'inhibition irreversible de la butylcholinesterase par le thio-tepa et le methyl-parathion a ete etudiee en suivant l'hydrolyse d'une faible concentration de substrat en presence de l'inhibiteur

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23

Cheleski, Juliana. "Planejamento de inibidores da enzima diidroorotato desidrogenase de Trypanosoma cruzi por biocalorimetria." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/75/75131/tde-19052011-110337/.

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A doença de Chagas, causada pelo protozoário flagelado Trypanosoma cruzi, é uma doença tropical que enseja morte/morbidade de milhões de pessoas na América Latina. Por processos migratórios, vem-se estendendo ao sul dos Estados Unidos, Canadá, Europa, Austrália e Japão. Essa doença tem sido considerada super-negligenciada pela indústria farmacêutica, já que os dois fármacos disponíveis para o seu tratamento foram introduzidos há mais de quarenta anos e apresentam baixa eficácia com vários efeitos colaterais severos. Mais recentemente, a Organização Mundial da Saúde considerou a doença de Chaga

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Gottschalk, Ingo. "Chromatographic Studies of Solute Interactions with Immobilized Red Blood Cells and Biomembranes." Doctoral thesis, Uppsala University, Department of Biochemistry, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2668.

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<p>Specific and non-specific interactions of solutes with immobilized biomembranes were studied using chromatographic methods. Liposomes, proteoliposomes and red blood cell (RBC) membrane vesicles were immobilized by a freeze-thawing procedure, whereas whole RBCs were adsorbed in the gel beds using electrostatic interaction, binding to wheat germ agglutinin (WGA) or the streptavidin-biotin interaction. </p><p>Superporous agarose gel with coupled WGA was the most promising matrix for RBC adsorption and allowed frontal chromatographic analyses of the cells for about one week. Dissociation consta

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DEGORRE, CECCALDI FRANCOISE. "Synthese, structure, proprietes physicochimiques et etude "in vitro" du pouvoir reactivateur de nouveaux antidotes de l'acetylcholinesterase inhibee par des organophosphores." Paris 6, 1988. http://www.theses.fr/1988PA066182.

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26

Lagerquist, Hägglund Christine. "Affinity-, Partition- and Permeability Properties of the Human Red Blood Cell Membrane and Biomembrane Models, with Emphasis on the GLUT1 Glucose Transporter." Doctoral thesis, Uppsala University, Department of Biochemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3525.

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<p>The human glucose transporter GLUT1 is abundant in red blood cells, the blood-brain barrier and epithelial cells, where it mediates the transport of the energy metabolite, glucose. In the present work some properties of GLUT1, including affinity binding of both substrates and inhibitors, transport rates as well as permeabilities of aromatic amino acids and drug-membrane interactions were analyzed by chromatographic methods.</p><p>Reconstitution by size-exclusion chromatography on Superdex 75 from a detergent with a low CMC that provides monomeric GLUT1 was examined regarding D-glucose- and

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27

Gong, Yun. "Structure-property relationships of dyes as applied to dye-sensitized solar cells." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275007.

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This work investigates the correlation of structural and photovoltaic properties of dyes used in dye-sensitized solar cells. Experimental methods, including ultraviolet-visible spectroscopy, fluorescence spectroscopy, cyclic voltammetry and electrochemical impedance spectroscopy are employed to study optical and electrochemical properties of dye molecules. Computational methods, including density functional theory and time-dependent density functional theory, are used to validate and predict the optical and electronic properties of dye molecules, in their isolated state and once embedded into

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28

Neubauer, Svetlana. "Untersuchungen von inter- und intramolekularen Interaktionen des globalen Regulators AbrB und dessen Antirepressors AbbA." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16887.

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Aus den frühen Bindungsstudien des globalen Regulators AbrB mit der ausgedehnten phyC-Promotorregion von Bacillus amyloliquefaciens FZB45 konnte ein mehrstufiger kooperativer Bindungsprozess abgeleitet werden. Dabei verlangt die AbrB-vermittelte Repression von phyC nach Integrität zweier großer Bindungsstellen, ABS1 und ABS2, die 162 bp voneinander entfernt liegen. In der vorliegenden Arbeit wurden die ersten Echtzeitkinetiken zur DNA-AbrB-Interaktion mittels der Oberflächenplasmonresonanz (SPR) gemessen und analysiert. AbrB zeigte hohe Affinitäten zu den 40 bp langen Oligonukleotiden, die de

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Tsai, Lily, and 蔡苓莉. "A human rab GDP-dissociation inhibitor homolog from Trichoderma koningii G-39. Sequencing and analysis." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/34943280901841870491.

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Gulbrandsen, Ann Cecilie, and Thor Martin Svartaas. "INFLUENCE OF MELTING RATE ON THE DISSOCIATION OF GAS HYDRATES WITH THE KINETIC INHIBITOR PVCAP PRESENT." 2008. http://hdl.handle.net/2429/1072.

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The kinetic inhibitor Poly Vinyl Caprolactam (PVCap) was added as a kinetic inhibitor to the gas-water system. Different hydrate formers were used in order to obtain formation of the different hydrate structures (sI, sII and sH). All hydrate structures were formed with PVCap. The effect of applying different melting rates was investigated. The isochoric technique was used to obtain dissociation temperatures and corresponding pressures. The melting rate was found to be a parameter influencial for the dissociation temperature. Even for very slow melting rates such as 0.0125 Kelvin per hour, the

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Ray, Paresh Chandra. "Measurement Of Dissociation Constant (Ka) And Partition Coefficient (KP) Of Weak Organic Acids From Their First Hyperpolarizabilities." Thesis, 1996. http://etd.iisc.ernet.in/handle/2005/1731.

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Jeřábková, Kateřina. "Vliv dlouhodobého podávání morfinu na opioidní receptory v mozkové kůře potkana." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-307435.

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-5- ABSTRACT A huge effort has been put in determining the mechanism of the development of tolerance and dependence in context of clinical use of morphine for treatment of severe pain. Understanding of this mechanism would help to design new and more efficient pharmaceuticals. This diploma paper discus the opiate receptors with a special focus on long-term effect of chronic morphine treatment, which was determined using a radioligand binding assays with a non-selective antagonist [3 H]Diprenorphine. One of the goals of this work was to create and optimise a method for preparation of pure plasm

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Gulbrandsen, Ann Cecilie, and Thor Martin Svartaas. "INFLUENCE OF FORMATION TEMPERATURE AND INHIBITOR CONCENTRATION ON THE DISSOCIATION TEMPERATURE FOR HYDRATES FORMED WITH POLY VINYL CAPROLACTAM." 2008. http://hdl.handle.net/2429/1071.

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Inhibitor containing systems were investigated for hydrate structures I and II. The kinetic inhibitor PVCap was added to the water phase for each hydrate structure. Dissociation temperatures were determined for various formation temperatures and PVCap concentrations. Obtained dissociation temperatures were compared with corresponding values calculated with CSMHYD. Differences between experimental and calculated values were compared for various formation temperatures and inhibitor concentrations. Comparison revealed that these parameters (formation temperature and concentration) had an eff

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Chu, Chi-Shuen, та 朱祁舜. "β2-glycoprotein I is involved in the up-regulation of Rho guanine nucleotide dissociation inhibitor-α in Huh7 cells". Thesis, 2005. http://ndltd.ncl.edu.tw/handle/89350256785856709970.

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碩士<br>國立陽明大學<br>生物化學研究所<br>93<br>Beta-2-glycoprotein I (β2-GPI) is a human plasma protein mainly produced by the liver. Although various pathological properties have been attributed to this protein, its biological role and intracellular distribution still remain unclear. In our previous study, β2-GPI was proved to protect cells from apoptosis in J774A.1 macrophages and human coronary artery smooth muscle cells (HCASMCs) treated with nitric oxide donors. The aim of this study was to investigate the proteomic profile in β2-GPI over-expressed cells, and to clarify the role of β2-GPI in apoptosis.

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Suchý, Miroslav. "Fyzikálně chemické vlastnosti léčiv." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-345322.

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1. Abstract Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Biophysics and Physical Chemistry Candidate: Miroslav Suchy Supervisor: Ing. Vladimir Kubicek, CSc. Title of Diploma Thesis: Physico-Chemical properties of drugs To test physico-chemical properties of new molecules is necessary during drug development. It could be helpful to understand or predict the pharmacokinetic parametres of a new drug in vivo/in vitro experiments. One of this parameters is a dissociation constant (pK). Dissociation constant is defined as " Number on pH scale, wherein is just fift

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Ou, Yung, та 區永. "To investigate the role of arginine methylation of Rho GDP dissociation inhibitor α (RhoGDIα) in megakaryocytic differentiation of K562 cells". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/74531624675471808738.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>101<br>Megakaryocytes are the precursors of platelets and thus play an essential role in blood clotting. K562 is a human leukemia cell line that can be induced by PMA (phorbol 12-myristate 13-acetate) to undergo megakaryocytic (MK) differentiation and has been used as a cell model for studying MK differentiation. The Rho family belongs to the small GTPase superfamily and GDP-dissociation inhibitor α (RhoGDIα) suppresses the activity of Rho. Our previous study has shown that RhoGDIα promoted MK differentiation. RhoGDIα has been reported to contain three di-methylated

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Gulbrandsen, Ann Cecilie, and Thor Martin Svartaas. "INFLUENCE OF A SYNERGIST ON THE DISSOCIATION OF HYDRATES FORMED IN THE PRESENCE OF THE KINETIC INHIBITOR POLY VINYL CAPROLACTAM." 2008. http://hdl.handle.net/2429/1070.

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Laboratory tests have been performed using a stirred cell where SI and SII gas hydrates have been formed under the presence of the kinetic inhibitor Poly Vinyl Caprolactam (PVCap) and INHIBEX. The latter is a mixture containing 50wt% PVCap 2k and 50wt% butyl glycol. The effect of PVCap is enhanced by the presence of butyl glycol; the latter acts as a synergist for the former. Dissociation temperatures were obtained and compared for hydrates formed 1) in presence of PVCap and 2) in presence of INHIBEX. The effect of INHIBEX concentration on the temperature of dissociation was also investig

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Lin, Wen-Ling, та 林玟伶. "To investigate the potential role of Rho GDP dissociation inhibitor α (RhoGDIα) in PMA-induced megakaryocytic differentiation of K562 cells". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/e8svf9.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>99<br>The mitogen-activated protein kinase (MAPK) pathways regulate various cellular functions, including differentiation. Activation of Erk MAPK pathway promotes megakaryocytic (MK) differentiation and p38 MAPK pathway plays a negative role in MK differentiation. K562 is a multipotent human leukemia cell line which can be induced to differentiate into various lineages including megakaryocytes. Upon PMA (phorbol 12-myristate 13-acetate) treatment, K562 cells display characteristics of MK and are often used as a model cell line. Our previous study demonstrated that PR

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Kawamura, Taro, Michika Ohtake, Yasuhide Sakamoto, Yoshitaka Yamamota, Hironori Haneda, Takeshi Komai, and Satoru Higuchi. "EXPERIMENTAL STUDY OF ENHANCED GAS RECOVERY FROM GAS HYDRATE BEARING SEDIMENTS BY INHIBITOR AND STEAM INJECTION METHODS." 2008. http://hdl.handle.net/2429/1401.

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The inhibitor and steam injection methods have been examined using a laboratory-prepared methane hydrate bearing sediment. New experimental apparatuses have been designed and constructed. In the case of inhibitor injection, the measurement of gas production vs. time suggested that the inhibitor increased dissociation rate. Core temperature decreased upon the inhibitor injection, in contrast to that in the case of pure water injection. The observed pressure differentials between the inlet and outlet of the core sample suggest that the inhibitor effectively prevented the hydrate reformation with

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Kwasek, Anna. "Kinetyczne i termodynamiczne badania oddziaływań hemu z ludzką $\alpha_{1}$-mikroglobuliną." Praca doktorska, 2011. https://ruj.uj.edu.pl/xmlui/handle/item/274859.

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Boyle, David. "Surface Complexation Modelling of the Adsorption of Cd(II), Cu(II), and Ni(II) to the Roots of Triticum turgidum." Thesis, 2012. http://hdl.handle.net/10214/5315.

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The goal of this study was to characterize the binding sites on the surface of wheat roots, Triticum turgidum, involved in the adsorption of protons and metals, and quantify the thermodynamic constants needed for a surface complexation model to predict metal binding. The adsorption of protons, Cd(II), Cu(II), and Ni(II) to the root surface as a function of pH and ionic strength in single metal exposure scenarios was quantitatively described using potentiometric titrations, batch metal adsorption experiments, and the least squares fitting program FITEQL. Model predictions from single metal ex

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Raina, Anupam. "Neurodegeneration induced by ß-synuclein in the context of the neurotransmitter dopamine." Doctoral thesis, 2019. http://hdl.handle.net/00-1735-0000-0003-C011-0.

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Lorinčíková, Kateřina. "Stanovení a porovnání elektromigračních vlastností markerů pro izoelektrickou fokusaci." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-448696.

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The dependencies of electrophoretic mobility on pH were measured for a set of 14 markers used for isoelectric focusing that were developed by the group of Šlais and that are based on substitutions on the nitrophenol core, and for a kit consisting of 5 pI markers developed by Shimura, which have an oligopeptide structure. The dissociation constants and limiting electrophoretic mobilities of these compounds were obtained from the dependencies with the use of the program AnglerFish. The isoelectric point values of the compounds were consequently calculated using the obtained data. A comparison of

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Tummanapelli, Anil Kumar. "Ab Initio Molecular Dynamics Studies of Bronsted Acid-Base Chemistry in Aqueous Solutions." Thesis, 2015. http://etd.iisc.ernet.in/2005/3943.

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Knowledge of the dissociation constants of the ionizable protons of weak acids in aqueous media is of fundamental importance in many areas of chemistry and biochemistry. The pKa value, or equilibrium dissociation constant, of a molecule determines the relative concentration of its protonated and deprotonated forms at a speciﬁed pH and is therefore an important descriptor of its chemical reactivity. Considerable eﬀorts have been devoted to the determination of pKa values by deferent experimental techniques. Although in most cases the determination of pKa values from experimental is straightforw

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