Log in

Relevant bibliographies by topics / Dissolution study of methyldopa and Hydrochlorothiazide / Journal articles

To see the other types of publications on this topic, follow the link: Dissolution study of methyldopa and Hydrochlorothiazide.

Journal articles on the topic 'Dissolution study of methyldopa and Hydrochlorothiazide'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 42 journal articles for your research on the topic 'Dissolution study of methyldopa and Hydrochlorothiazide.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

H.N, Khan* Kodli Puja Sana Javeria MD Zameeruddin A. G. Mangulkar V.B Bharkad. "STABITY INDICATING DISSOLUTION METHOD DEVELOPMENT FOR ESTIMATION OF METHYLDOPA AND HYDROCHLOROTHIAZIDE IN COMBINE DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3024–32. https://doi.org/10.5281/zenodo.910187.

Full text

Abstract:

The aim of this work was to develop validate a dissolution test for Methyldopa and Hydrochlorothiazide in combination tablets using spectrophotometric method. The dissolution established conditions were 900 mL of 0.1M HCl pH 1.0 as dissolution medium, using a paddle apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method the areas of solution were recorded at 274-284 nm and266-276 nm for Methyldopa and Hydrochlorothiazide respectively. It can be concluded that the method developed consists in an efficient alternative for assay of dissolution for t

APA, Harvard, Vancouver, ISO, and other styles

2

H.N, Khan* Kodli Puja Sana Javeria MD Zameeruddin A. G. Mangulkar V.B Bharkad. "STABITY INDICATING DISSOLUTION METHOD DEVELOPMENT FOR ESTIMATION OF METHYLDOPA AND HYDROCHLOROTHIAZIDE IN COMBINE DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3024–32. https://doi.org/10.5281/zenodo.897504.

Full text

Abstract:

The aim of this work was to develop validate a dissolution test for mthyldopa and Hydrochlorothiazide in combination tablets using spectrophotometric method. The dissolution established conditions were 900 mL of 0.1M HCl pH 1.0 as dissolution medium, using a paddle apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method the area of solution were recorded at 274-284 nm and266-276 nm for MD and HCTZ respectively . it can be concluded that the method developed consists in an efficient alternative for assay of dissolution for tablets. The method was v

APA, Harvard, Vancouver, ISO, and other styles

3

Fernandez, P. G., W. Snedden, J. W. Snellen, A. B. Galway, and C. Nath. "Increased metabolic heat production following chronic alpha-methyldopa therapy in hypertensives." Canadian Journal of Physiology and Pharmacology 64, no. 2 (1986): 138–44. http://dx.doi.org/10.1139/y86-021.

Full text

Abstract:

The objective of this study was to measure metabolic heat production in mild-moderate hypertensives when given chronic alpha-methyldopa for control of hypertension and to compare this with hydrochlorothiazide. Four men and one woman, age range 29–55 years, euthyroid, and not previously on alpha-methyldopa, had their drugs replaced by placebo for 4 weeks, and then alpha-methyldopa or hydrochlorothiazide was randomized single blindedly to patients. The dose of each drug was increased until the ambulatory diastolic blood pressure was less than 95 mmHg (1 mmHg = 133.322 Pa), and then the dose was

APA, Harvard, Vancouver, ISO, and other styles

4

Ammanage, Anand Shripal, Yojana Dadasaheb Patil, Jagadish Kamalanath Saboji, Amolkumar Ashok Kempwade, and Ravindra Durdundayya Hiremath. "EXPLORING THE POTENTIAL OF ORODISPERSIBLE TABLET OF ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE DRUG COMBINATION." INDIAN DRUGS 57, no. 03 (2020): 47–54. http://dx.doi.org/10.53879/id.57.03.11333.

Full text

Abstract:

The objective of the present work was to formulate and evaluate orodispersible tablets of enalapril maleate and hydrochlorothiazide combination to overcome the shortcomings of conventional dosage forms and improve patient compliance. Eleven formulations were prepared by wet granulation method using sodium starch glycolate as superdisintegrant and microcrystalline cellulose and Pearlitol 200 SD as diluents. The process variables were optimized to get desired characteristics. Various pre-compression and post-compression quality control parameters were evaluated. The wetting and disintegration ti

APA, Harvard, Vancouver, ISO, and other styles

5

Talele, Swati, Priyanka Kajale, Shital Bhil, Amit Gaikwad, and Laxmikant Borse. "Formulation of Drug-polyelectrolyte Complex for Enhancement of Solubility of Hydrochlorthiazide." Biosciences Biotechnology Research Asia 20, no. 4 (2023): 1291–302. http://dx.doi.org/10.13005/bbra/3176.

Full text

Abstract:

ABSTRACT: The objective of this work is to formulate Nanoplex formulation which enhances the drug solubility and also to enhance the dissolution rate of the formulation which were prepared. Complex nanoplex is formed when positively or negatively charged molecules of the drug react with oppositely charged polyelectrolyte. In this study, we use hydrochlorothiazide as a study drug and dextran sulphate as anionic polyelectrolyte. During the procedure crystalline nanoplex is formed due to electrostatic interactions between API and polyelecrolyte. The nanoplex shaped by this method upgrades dissolv

APA, Harvard, Vancouver, ISO, and other styles

6

Al-Kubati, Sana Saleh, and Fairoz Adel Hammed. "Pharmaceutical Study to Assess the Equivalence of the Commercial Brands of Losartan Potassium Tablets Available in Aden Governorate, Yemen." University of Aden Journal of Natural and Applied Sciences 28, no. 2 (2025): 75–85. https://doi.org/10.47372/uajnas.2024.n2.a07.

Full text

Abstract:

Losartan potassium, a non-peptide angiotensin II receptor antagonist, is prescribed by the physicians for hypertension treatment. In Aden governorate, Yemen, losartan is available as oral tablets and tablets combining losartan potassium and hydrochlorothiazide. A study comparing generic brands of 50 mg Losartan potassium tablets to their reference brand was conducted to determine their pharmaceutical equivalency. The study involved quality control parameters and in vitro dissolution studies using the USP method. The results showed that the seven brands of losartan potassium tablets met the spe

APA, Harvard, Vancouver, ISO, and other styles

7

Povetkin, S. V., V. I. Gikavyj, N. G. Bachinski, et al. "Comparative Pharmacoepidemiological Assessment of Antihypertensive Drugs Administration Structure in Pregnant Women in Routine Medical Practice in Kursk and Chisinau." Rational Pharmacotherapy in Cardiology 18, no. 5 (2022): 571–77. http://dx.doi.org/10.20996/1819-6446-2022-10-02.

Full text

Abstract:

Aim. To study the structure of antihypertensive drugs prescription in pregnant women in routine practice in Kursk and Chisinau.Material and methods. The study design was observational descriptive cross-sectional. Authors conducted a survey of doctors in medical organizations in Kursk and Chisinau in 2017-2018.Results. Respondents from Kursk and Chisinau preferred methyldopa in prescriptions of central alpha-adrenergic receptor agonists. Doctors from Chisinau used clonidine in 14.3% of cases. The leading place in the group of calcium channel blockers belonged to short-acting nifedipine. Among b

APA, Harvard, Vancouver, ISO, and other styles

8

Leon, Rosmery Merma, Michele Georges Issa, Marcelo Dutra Duque, Josiane Souza Pereira Daniel, and Humberto Gomes Ferraz. "Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and Valsartan Tablets." Pharmaceutics 15, no. 6 (2023): 1735. http://dx.doi.org/10.3390/pharmaceutics15061735.

Full text

Abstract:

Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products marketed in Brazil and Peru. Firstly, in vitro dissolution tests were performed using a fractional factorial design 33−1. Then, DDDPlus™ was used to carry out experimental design assays of a complete factorial design 33. Data from the first stage were used to obtain calibration constants for in silico simu

APA, Harvard, Vancouver, ISO, and other styles

9

Kathpalia, H., and K. Jogi. "DESIGN AND OPTIMIZATION OF IMMEDIATE RELEASE TABLETS OF HYDROCHLOROTHIAZIDE USING THE DESIGN OF EXPERIMENTS APPROACH." INDIAN DRUGS 53, no. 09 (2016): 27–33. http://dx.doi.org/10.53879/id.53.09.10562.

Full text

Abstract:

The aim of the present study was to develop and optimize immediate release tablets using hydrochlorothiazide (HCTZ) as a model drug candidate applying Design of Experiments (DoE) approach. Immediate release tablets were prepared using corn starch as a disintegrant and Polysorbate 80 as a solubilizer. Risk assessment was carried out with subsequent application of 22 factorial design in duplicate for evaluating the interactions and effects of the design factors on critical quality attributes. The design space was obtained by applying DOE and multivariate analysis, so as to ensure desired disinte

APA, Harvard, Vancouver, ISO, and other styles

10

Fadhilla, Salma Nara, and Dharma Permana. "The use of antihypertensive drugs in the treatment of essential hypertension at outpatient installations, Puskesmas Karang Rejo, Tarakan." Yarsi Journal of Pharmacology 1, no. 1 (2020): 7–14. http://dx.doi.org/10.33476/yjp.v1i1.1209.

Full text

Abstract:

Background: Essential hypertension is the most common type of hypertension, affecting 95% of hypertensive patients. Essential hypertension can be managed through a combination lifestyle changes and antihypertensive drugs. The aim of this study was to know the use of antihypertensive drugs in the treatment of essential hypertensive at outpatient installations, Puskesmas Karang Rejo, Tarakan.Methods: The research method is descriptive by using secondary data from complete patient medical records of the essential hypertension patients undergoing outpatient treatment at Puskesmas Karang Rejo, Tara

APA, Harvard, Vancouver, ISO, and other styles

11

Blatnik, Sandra Urek, Rok Dreu, and Stanko Srčič. "Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets." Acta Pharmaceutica 65, no. 4 (2015): 383–97. http://dx.doi.org/10.1515/acph-2015-0031.

Full text

Abstract:

Abstract During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance. The demographic shift toward older population increases the use of combination therapy as polypharmacy. Hydrochlorothiazide (HCTZ), as a model drug, is most commonly used in the treatment of hypertension, congestive heart failure and as a diuretic. The aim of the present study is to investigate the effect of the local environment on dissolution and stability behaviour of HCTZ in fixed m

APA, Harvard, Vancouver, ISO, and other styles

12

Khan, Hamid, Mushir Ali, Alka Ahuja, Javed Ali, and Sayeed Ahmad. "Application of Validated HPTLC Method for Dissolution Study of FDC Tablets Containing Telmisartan and Hydrochlorothiazide." Research Journal of Pharmacy and Technology 10, no. 4 (2017): 1149. http://dx.doi.org/10.5958/0974-360x.2017.00207.4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Shaik, Ameer Pasha, and Vinod Naidu. "Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes." Future Journal of Pharmaceuticals and Health Sciences 4, no. 1 (2024): 69–79. http://dx.doi.org/10.26452/fjphs.v4i1.566.

Full text

Abstract:

One of the many different carriers for getting a drug molecule to its site of action is a niosome, also known as a nonionic surfactant vesicle. Hydrophilic and hydrophobic medicines can both be trapped by them. The primary purpose of the medication hydrochlorothiazide, an angiotensin II type 1 receptor (AT1) antagonist, is to treat high blood pressure. Using cholesterol and nonionic surfactants (span 60) at varying concentrations, niosomes containing hydrochlorothiazide were created by the thin film hydration method. FTIR investigations, in vitro release studies, vesicular diameter, drug conte

APA, Harvard, Vancouver, ISO, and other styles

14

Sk, Ameer Pasha. "Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes." Formulation, Evaluation and Characterization of Hydrochlorothiazide Niosomes 4, no. 1 (2025): 69–79. https://doi.org/10.5281/zenodo.14649643.

Full text

Abstract:

One of the many different carriers for getting a drug molecule to its site of action is a niosome, also known as a nonionic surfactant vesicle. Hydrophilic and hydrophobic medicines can both be trapped by them. The primary purpose of the medication hydrochlorothiazide, an angiotensin II type 1 receptor (AT1) antagonist, is to treat high blood pressure. Using cholesterol and nonionic surfactants (span 60) at varying concentrations, niosomes containing hydrochlorothiazide were created by the thin film hydration method. FTIR investigations, in vitro release studies, vesicular diameter, drug conte

APA, Harvard, Vancouver, ISO, and other styles

15

Patel, Ravikumar, and Jayvadan Patel. "Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide." Acta Pharmaceutica 61, no. 1 (2011): 73–82. http://dx.doi.org/10.2478/v10007-011-003-9.

Full text

Abstract:

Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide In situ forming intragastric controlled-release formulation is a new technology in the field of oral controlled-release delivery systems. The objective of this study was to develop formulations that can control drug release up to 24 hours. In addition, a combination of appropriate polymers and solvents was selected that could form a drug loaded gel at the process temperature of 60-70 °C, which gel could turn into a rigid mass upon exposure to dissolution fluid at body temperature. The

APA, Harvard, Vancouver, ISO, and other styles

16

Sonpal, Rakshit N., Pragna Shelat, and Anita Lalwani. "Solubility Enhancement of Hydrochlorothiazide using a Novel Drug-Drug Solid Dispersion Technology." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2924–36. http://dx.doi.org/10.37285/ijpsn.2015.8.3.6.

Full text

Abstract:

Fixed dose combination (FDC) is commonly used in pharmaceuticals to reduce pill burden and optimize the drug therapy. The recent advancements in combinatorial chemistry often lead to drugs with low aqueous solubility. Many FDC’s contain at least one drug with suboptimal physicochemical properties like BCS class II drugs for which its poor aqueous solubility may often be a limiting factor to its bioavailability. Considering the above fact, a novel drug – drug solid dispersion has been developed in present study, wherein a poorly soluble drug hydrochlorothiazide has been solid dispersed in a hyd

APA, Harvard, Vancouver, ISO, and other styles

17

Murillo-Fernández, Mac Arturo, Ernesto Montero-Zeledón, Ariadna Abdala-Saiz, José Roberto Vega-Baudrit, and Andrea Mariela Araya-Sibaja. "Interaction and Compatibility Studies in the Development of Olmesartan Medoxomil and Hydrochlorothiazide Formulations under a Real Manufacturing Process." Pharmaceutics 14, no. 2 (2022): 424. http://dx.doi.org/10.3390/pharmaceutics14020424.

Full text

Abstract:

A drug–drug and drug–excipient interactions and compatibilities study was conducted for two fixed-dose combination (FDC) products containing olmesartan medoxomil (OLM)/hydrochlorothiazide (HCT) 20/12.5 mg and OLM/HCT 40/12.5 mg during their development including storage. The study consisted of the evaluation of samples retrieved during all stages of a real manufacturing process. Powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR), and contact angle techniques were applied to the samples to determine i

APA, Harvard, Vancouver, ISO, and other styles

18

Dhekale, Pallavi Shrirang. "Spectroscopic Investigation for Photo stability of Hydrochlorothiazide Complexes with β-Cyclodextrin and HPMC." Asian Journal of Pharmaceutical and Clinical Research 10, № 7 (2017): 314. http://dx.doi.org/10.22159/ajpcr.2017.v10i7.18874.

Full text

Abstract:

Hydrochlorothiazide (HCT) is a poorly water-soluble drug. The aim of this study was to determine whether inclusion complexes between β-cyclodextrin and HCT are formed and also studied effect of auxiliary substance (HPMC) on HCT, photo-stability of HCT and to characterize these. Equimolar HCT/ βCD solid systems in the presence or absence of 0.2% (w/v) of HPMC were prepared by kneading method. The systems were characterized by phase solubility, Dissolution study, FTIR, DSC and the photo-stability test followed by u.v. spectroscopy. The results suggest that true binary and ternary inclusion compl

APA, Harvard, Vancouver, ISO, and other styles

19

R, Natarajan, N. Patel, Rajendran N N, and M. Rangapriya. "Formulation and Evaluation of Immediate Release Bilayer Tablets of Telmisartan and Hydrochlorothiazide." International Journal of Pharmaceutical Sciences and Nanotechnology 4, no. 3 (2011): 1477–83. http://dx.doi.org/10.37285/ijpsn.2011.4.3.6.

Full text

Abstract:

The main goal of this study was to develop a stable formulation of antihypertensive drugs telmisartan and hydrochlorothiazide as an immediate-release bilayer tablet and to evaluate the dissolution profile in comparison with a reference product. The formulation development work was initiated with wet granulation. Telmisartan was converted to its sodium salt by dissolving in aqueous solution of sodium hydroxide to improve solubility and drug release. Lactose monohydrate and microcrystalline cellulose were used as diluents. Starch paste is prepared in purified water and was used as the binder. So

APA, Harvard, Vancouver, ISO, and other styles

20

Hasan, Md Asif, Sabiha Sultana, Sabiha Sultana, Md Masud Kaisar Bhuiyan, Md Selim Reza, and Mohammad Salim Hossain. "Formulation and In vitro Characterization of Hydrochlorothiazide Gastroretentive Floating Drug Delivery System." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (2016): 163–70. http://dx.doi.org/10.3329/dujps.v14i2.28506.

Full text

Abstract:

The purpose of the study was to develop and optimize floating bioadhesive gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach, using hydrochlorothiazide (HCTZ) as a model drug. Formulated matrix tablets were prepared by direct compression method with two different rate controlling polymer HPMC K4M and Carbopol 971. The formulated tablets were evaluated for physical characterization, floating lag time, swelling index and drug content uniformity. The drug release study was carried out in 0.1N HCl as the me

APA, Harvard, Vancouver, ISO, and other styles

21

Ikonen, Jenni, Ilpo Nuutinen, Marjo Niittynen, et al. "Presence and Reduction of Anthropogenic Substances with UV Light and Oxidizing Disinfectants in Wastewater—A Case Study at Kuopio, Finland." Water 13, no. 3 (2021): 360. http://dx.doi.org/10.3390/w13030360.

Full text

Abstract:

Anthropogenic substances are a major concern due to their potential harmful effects towards aquatic ecosystems. Because wastewater treatment plants (WWTPs) are not designed to remove these substances from wastewater, a part of the anthropogenic substances enter nature via WWTP discharges. During the spring 2019, the occurrence of anthropogenic substances in the municipal wastewater effluent in Kuopio, Finland, was analysed. Furthermore, the capacity of selected disinfection methods to reduce these substances from wastewater was tested. The disinfection methods were ozonation (760 mL min−1) wit

APA, Harvard, Vancouver, ISO, and other styles

22

Ranjous, Yasmin, Géza Regdon, Klára Pintye-Hódi, et al. "Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites." Nanomaterials 9, no. 10 (2019): 1406. http://dx.doi.org/10.3390/nano9101406.

Full text

Abstract:

Recently, there has been an increasing interest in the application of nanotubular structures for drug delivery. There are several promising results with carbon nanotubes; however, in light of some toxicity issues, the search for alternative materials has come into focus. The objective of the present study was to investigate the influence of the applied solvent on the composite formation of titanate nanotubes (TNTs) with various drugs in order to improve their pharmacokinetics, such as solubility, stability, and bioavailability. Composites were formed by the dissolution of atenolol (ATN) and hy

APA, Harvard, Vancouver, ISO, and other styles

23

Gonzalez-Alvarez, Isabel, Alejandro Ruiz-Picazo, Ruben Selles-Talavera, et al. "In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug." Pharmaceutics 16, no. 3 (2024): 390. http://dx.doi.org/10.3390/pharmaceutics16030390.

Full text

Abstract:

The purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products with hydrochlorothiazide (HCTZ, BCS class III) (Co-Diovan® Forte as reference and two generic formulations in development) by conducting in vivo predictive dissolution with a gastrointestinal simulator (GIS) and a physiologically based biopharmaceutic model (PBBM). In the first BE study, the HCTZ failed, but the VALS 90% CI of Cmax and the AUC were within the acceptance limits, while, in the second BE study, the HCTZ 90% CI of Cmax and th

APA, Harvard, Vancouver, ISO, and other styles

24

Shabana, Md Khatija, Devadasu Chapala, and Puttagunta Srinivasa Babu. "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF AMLODIPINE AND HYDROCHLOROTHIAZIDE IN TABLETS: APPLICATION TO DISSOLUTION STUDY." INTERNATIONAL RESEARCH JOURNAL OF PHARMACY 4, no. 8 (2013): 177–83. http://dx.doi.org/10.7897/2230-8407.04835.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Ermawati, Dian Eka, Anif Nur Artanti, Dyah Ayu Ambarwati, Niken Rosyana Dewi Septini, Sholichah Rohmani, and Wisnu Kundarto. "STUDY OF KINETICS MODEL OF FLAVONOID TOTAL RELEASE IN PATCH OF ANTIHYPERTENSIVE HERBS." Journal of Pharmaceutical Sciences and Community 18, no. 1 (2021): 7–14. http://dx.doi.org/10.24071/jpsc.002203.

Full text

Abstract:

The liquid extract of antihypertensive herbs could reduce blood pressure equivalent to Hydrochlorothiazide 25 mg based on research conducted in “Hortus Medicus” clinic, Tawangmangu, Central Java, but parameters of herbal medicine taste, design, and packaging had the lowest scores. Transdermal patch was chosen as an alternative to resolve those problems. Polymers determined the effectiveness of the active substance release from the formula. Patch was formulated from combination of hydrophilic hydroxy methylcellulose (HPMC) and carboxymethylcellulose natrium (CMC-Na) polymer which would produce

APA, Harvard, Vancouver, ISO, and other styles

26

Choncheewa, Chai Ek, and Thawatchai Phaechamud. "Simultaneous Determination of Hydrochlorothiazide and Propranolol Hydrochloride in Powder Mixture and Matrix Tablet Using First Derivative Ultraviolet Spectrophotoscopy." Advanced Materials Research 581-582 (October 2012): 150–53. http://dx.doi.org/10.4028/www.scientific.net/amr.581-582.150.

Full text

Abstract:

Normal UV-spectrophotoscopy [D0] cannot determine the combined drug in the formulation due to overlapping of the absorbance of each compound hence the derivative UV-spectrophotoscopy is used to determine the combined drug simultaneously. For determination of both hydrochlorothiazide [HCT] and propranolol hydrochloride [Pro] in powder mixture and matrix tablet, the first order derivative UV-spectrophotoscopy [D1] was employed in this study. This method showed good accuracy and precision for simultaneous determination of both drugs. Recovery was 106.59% and 97.11% for Pro and HCT, respectively.

APA, Harvard, Vancouver, ISO, and other styles

27

Khan, Amjad, Zafar Iqbal, Yasar Shah, et al. "Enhancement of dissolution rate of class II drugs (Hydrochlorothiazide); a comparative study of the two novel approaches; solid dispersion and liqui-solid techniques." Saudi Pharmaceutical Journal 23, no. 6 (2015): 650–57. http://dx.doi.org/10.1016/j.jsps.2015.01.025.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Vlachou, Marilena, and Vangelis Karalis. "An In Vitro–In Vivo Simulation Approach for the Prediction of Bioequivalence." Materials 14, no. 3 (2021): 555. http://dx.doi.org/10.3390/ma14030555.

Full text

Abstract:

The aim of this study was to develop a new in vitro–in vivo simulation (IVIVS) approach in order to predict the outcome of a bioequivalence study. The predictability of the IVIVS procedure was evaluated through its application in the development process of a new generic product of amlodipine/irbesartan/hydrochlorothiazide. The developed IVIVS methodology is composed of three parts: (a) mathematical description of in vitro dissolution profiles, (b) mathematical description of in vivo kinetics, and (c) development of joint in vitro–in vivo simulations. The entire programming was done in MATLAB®

APA, Harvard, Vancouver, ISO, and other styles

29

Adamov, Ivana, Đorđe Medarević, Branka Ivković, Aleksandar Ivković, and Svetlana Ibrić. "Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill." Arhiv za farmaciju 72, no. 6 (2022): 674–88. http://dx.doi.org/10.5937/arhfarm72-40365.

Full text

Abstract:

Ever since 3D printing was introduced to the field of pharmacy, it has caused a paradigm shift from the manufacturing of large-scale to small batches of medicines tailored accordingly to the specific needs of patients. This study aimed to formulate and fabricate two-layered 3D tablets using the digital light processing (DLP) technique. Hydrochlorothiazide (HHT,5%,w/w) and warfarin sodium (WS,5%,w/w) were selected as model drugs. The printing process was initiated with 0.1% of photoinitiator, at a constant ratio of poly(ethylene glycol)diacrylate and poly(ethylene glycol) 400, 1:1, with the add

APA, Harvard, Vancouver, ISO, and other styles

30

Edueng, Khadijah, Denny Mahlin, Johan Gråsjö, Olivia Nylander, Manish Thakrani, and Christel A. S. Bergström. "Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage." Molecules 24, no. 15 (2019): 2731. http://dx.doi.org/10.3390/molecules24152731.

Full text

Abstract:

This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibenclamide, hydrocortisone, hydrochlorothiazide, ketoconazole, and sulfathiazole were used as model APIs. The parameters used to assess the supersaturation potential and crystallization kinetics were the maximum supersaturation concentration (Cmax,app), the area under the curve (AUC), and the crystallization rate constant (k). These were compared for fr

APA, Harvard, Vancouver, ISO, and other styles

31

Salim, Shah Afrin. "Formulation and evaluation of novel orodispersible tablet by drug-drug solid dispersion of metoprolol tartrate and hydrochlorothiazide." Biochemical and Cellular Archives, September 13, 2024. http://dx.doi.org/10.51470/bca.2024.24.2.3133.

Full text

Abstract:

This study investigates the effect of a novel drug-drug solid dispersion approach on the dissolution of hydrochlorothiazide in a fixed-dose combination with metoprolol tartrate. Solid dispersions of hydrochlorothiazide and metoprolol tartrate (12.5 mg: 25 mg) were prepared using the solvent evaporation technique. These dispersions were characterized by differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR). The prepared solid dispersions, along with selected excipients, were compressed into orodispersible tablets and evaluated for precompression and post compre

APA, Harvard, Vancouver, ISO, and other styles

32

Lee, M. S., C. L. Huang, S. H. Huang, Y. P. Chen, C. J. Chen, and K. C. Wen. "A comparative study on the dissolution profiles of commercial hydrochlorothiazide tablets." Journal of Food and Drug Analysis 10, no. 1 (2020). http://dx.doi.org/10.38212/2224-6614.2772.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Raut, Prabhakar V., Sudhakar L. Padwal, Madhusudhan T. Bachute, and Satish A. Polshettiwar. "Development and Validation of RP-HPLC Chromatographic Dissolution Method for the Simultaneous Estimation of Ramipril and Hydrochlorothiazide from Solid Dosage Formulation." Journal of Pharmaceutical Research International, September 1, 2021, 203–17. http://dx.doi.org/10.9734/jpri/2021/v33i42b32440.

Full text

Abstract:

The present study describes the dissolution method development and validation of Ramipril and Hydrochlorothiazide in tablet dosage form by HPLC Method. A simple, rapid, selective, reproducible and isocratic reversed-phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated as per ICH guidelines. Analysis was performed on a Thermo, Sunniest C8 (150 mm x 4.6 mm, 5 µm) with the mobile phase consisting of mixing 500 mL of buffer solution and 500 mL of acetonitrile at a flow rate of 1.0mL/min. UV detection was performed at 210nm and the Run time for

APA, Harvard, Vancouver, ISO, and other styles

34

Wang, Yuanjian, Ruixun Wang, Huijia Wang, Ran Liu, Kaishun Bi, and Qing Li. "A Rapid, Sensitive, and High-throughput Method for the Simultaneous Determination of Antihypertensive Drug Combinations in Dog Plasma by UHPLC-MS/MS: The Assessment of Predicable Bioequivalence of In-vitro Dissolution Condition." Current Pharmaceutical Design 30 (July 2, 2024). http://dx.doi.org/10.2174/0113816128295265240613061905.

Full text

Abstract:

Background: Essential hypertension is a common clinical disease and a risk factor for cardiovascular and cerebrovascular diseases. Olmesartan medoxomil, amlodipine, and hydrochlorothiazide are commonly used antihypertensive drugs. The aim of this study was to establish a robust UPLC-MS/MS method for the simultaneous determination of olmesartan medoxomil, amlodipine, and hydrochlorothiazide in dog plasma. At the same time, the release in vivo and in vitro studies were conducted, and a preliminary in vitro-in vivo correlation (IVIVC) evaluation was performed. Methods: The bioequivalence experime

APA, Harvard, Vancouver, ISO, and other styles

35

Yadav, Akash. "Patient Centric Approach to Hypertension Fast Disintegrating Hydrochlorothiazide ODTs for Better Adherence." Journal of Pharmaceutical Research & Reports, April 30, 2025, 1–13. https://doi.org/10.47363/jprsr/2025(6)169.

Full text

Abstract:

The development of Oral Disintegrating Tablets (ODTs) for antihypertensive drugs represents a promising approach to improve patient adherence, especially for those with difficulty swallowing traditional tablets. This study focuses on the formulation and optimization of hydrochlorothiazide (HCTZ) ODT using Box-Behnken Design (BBD) for process optimization. The research employs excipients such as fenugreek seed powder, Cross-povidone and Locust bean gum as a superdisintegrant, Banana powder as binders, corn starch as a glidant, magnesium stearate as a lubricant, Microcrystalline Cellulose (MCC)

APA, Harvard, Vancouver, ISO, and other styles

36

Chou, Joe, Roger Lai, Jason Chou, Shelly Fu, and Li Chuan Chung. "Improve Bioequivalence predictions with PAMPA Dissolution using Etoricoxib and five other Drug Formulations." Research Journal of Pharmaceutical Dosage Forms and Technology, November 9, 2023, 223–28. http://dx.doi.org/10.52711/0975-4377.2023.00036.

Full text

Abstract:

In the generic drug formulation development, pilot bioequivalence (BE) study with a small group of subjects is the current practice for oral formulation prediction. However, due to the difficulty in differentiating the variation between subject and drug formulation with the current BE practice，a new instrument called PAMPA Dissolution is proposed to eliminate the subjects variation and to enhance the correlation between in vitro to in vivo absorption in BE study. PAMPA Dissolution simultaneously measures drug dissolution (Cb) and permeation (Pe), following the validated oral drug absorption eq

APA, Harvard, Vancouver, ISO, and other styles

37

Leonard, Stephanie A., Sara Siadat, Elliott K. Main, et al. "Chronic Hypertension During Pregnancy: Prevalence and Treatment in the United States, 2008–2021." Hypertension, June 17, 2024. http://dx.doi.org/10.1161/hypertensionaha.124.22731.

Full text

Abstract:

BACKGROUND: Treatment of chronic hypertension during pregnancy has been shown to reduce the risk of adverse perinatal outcomes. In this study, we examined the prevalence and treatment of chronic hypertension during pregnancy and assessed changes in these outcomes following the release of the updated 2017 hypertension guidelines of the American College of Cardiology and American Heart Association. METHODS: We analyzed the Merative TM Marketscan ® Research Database of United States commercial insurance claims from 2007 to 2021. We assessed the prevalence of chronic hypertension during pregnancy

APA, Harvard, Vancouver, ISO, and other styles

38

Da Silva Ferreira, Matheus, Gilmar Antônio De Carvalho Teles Júnior, Carlos Magno Ramos Carvalho Júnior, et al. "Evaluation of physicochemical properties and dissolution studies on quality control of low water solubility drugs (raw materials and pharmaceutical formulations)." Revista Colombiana de Ciencias Químico-Farmacéuticas 49, no. 2 (2020). http://dx.doi.org/10.15446/rcciquifa.v49n2.89486.

Full text

Abstract:

The purpose of this study was to evaluate physicochemical properties and dissolution studies of furosemide (FUR), hydrochlorothiazide (HCTZ) and nifedipine (NIF), low water solubility drugs, in raw materials and pharmaceutical formulations. Surface and physicochemical characterization techniques -scanning electronic microscopy (SEM), thermogravimetry (TG), X-ray diffraction (XRD) and infrared (IR) spectrometry- as well as physical and physicochemical tests on tablets and capsules were applied as supporting information on drug quality control. Simple, rapid, and efficient UV-Vis methods were de

APA, Harvard, Vancouver, ISO, and other styles

39

Sarafan, Negar, Afra Alipour, and Akram Shariati. "Drug-induced oral lichenoid reactions in patients consuming antihypertensive drugs." Cardiovascular Biomedicine Journal, March 11, 2023. http://dx.doi.org/10.18502/cbj.v2i2.12155.

Full text

Abstract:

Objectives: High blood pressure (HBP) is a persistent and widespread condition, and increasing numbers of patients are taking medication to reduce HBP symptoms and control blood pressure. Patients taking specific antihypertensive medications have been reported to experience oral lichenoid reactions. Various antihypertensive drugs have entered the market, and it is essential to study how they may affect the occurrence of oral lichenoid reactions. This study aimed at assessing the frequency of drug-induced oral lichenoid responses in patients receiving antihypertensive medications. Methods

APA, Harvard, Vancouver, ISO, and other styles

40

VINAYATA ATTAL and KRATIKA DANIEL. "IN VITRO, EX-VIVO, AND DISSOLUTION KINETIC STUDIES OF MOUTH-DISSOLVING SUBLINGUAL FILMS CONTAINING LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE." Asian Journal of Pharmaceutical and Clinical Research, July 7, 2025, 80–85. https://doi.org/10.22159/ajpcr.2025v18i7.54864.

Full text

Abstract:

Objectives: Sublingual films were designed for easy administration, rapid as well as slow drug absorption for obtaining controlled release action through the oral mucosa, bypassing the gastrointestinal tract and hepatic first-pass metabolism. This can result in a faster onset of action, enhanced bioavailability, and patient convenience since water isn’t required for administration. Films also offer precise dosing, enhanced drug stability, and targeted therapy for localized treatment within the oral cavity. These features make a non-invasive and painless alternative to injections, improving the

APA, Harvard, Vancouver, ISO, and other styles

41

Anumah, F. O., N. Ezeigwe, R. Mpazanje, et al. "Assessment of Primary Healthcare Centres for Care of NonCommunicable Diseases in the Federal Capital Territory, Abuja, Nigeria." Journal of Community Medicine and Primary Health Care 36, no. 2 (2024). http://dx.doi.org/10.4314/jcmphc.v36i2.2.

Full text

Abstract:

Background: Non-communicable diseases are the world’s biggest killers with an upward trajectory in the deleterious effect on global health burden. The aim of this study was to assess the capacity of the primary healthcare centres (PHCs) in the Federal Capital Territory (FCT) to implement WHO Essential Package for NCDs (WHOPEN) Methodology: This was a cross-sectional health facility-based survey conducted in 32 selected PHCs in the FCT. The WHO rapid assessment tool for primary healthcare facility capacity assessment for NCDs was adapted and used for data collection. Data was analysed using SPS

APA, Harvard, Vancouver, ISO, and other styles

42

Suslina, Svetlana, and Аhmed Alkhodri. "Preparation, Evaluation and Development Celecoxib Prolonged Release (PR) Tablets by using Cellulose Polyacrylic acid – based polymers." Research Journal of Pharmacy and Technology, April 23, 2022, 1727–31. http://dx.doi.org/10.52711//0974-360x.2022.00289.

Full text

Abstract:

Adilakshmi, D. et al. Simultaneous Formulation, Estimation and Evaluation of Allopurinol Sustained Release Tablets using various suitable Excipients. Asian Journal of Pharmaceutical Analysis. 2016; 6(3), 155-166.‏ DOI: 10.5958/2231-5675.2016.00025.9 James, H. P. et al. Smart polymers for the controlled delivery of drugs–a concise overview. Acta Pharmaceutica Sinica B. 2014; 4(2), 120-127. doi: 10.1016/j.apsb.2014.02.005 Salve, P. et al. Development and Evaluation of Sustained Release Dosage Form using Hydrophilic and Hydrophobic Materials. Research Journal of Pharmacy and Technology. 2016; 9(5

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!