Relevant bibliographies by topics / Distribution/partition coefficient

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Academic literature on the topic 'Distribution/partition coefficient'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Distribution/partition coefficient"

1

Davies, Matthew N., and Darren R. Flower. "A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides." Dataset Papers in Biology 2013 (May 16, 2013): 1–4. http://dx.doi.org/10.7167/2013/976758.

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Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure-activity relationship (QSAR) lags far behind the QSAR analysis of drug-like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of hydrophobicity. A partition coefficient () is the ratio between the concentrations of an uncharged chemical substance in two immiscible phases: most typically water and an organic solvent, usually 1-octanol. A distribution coefficient () is the equivalent ratio for charged molecules. We report here a compilation of partition and distribution coefficients for linear peptides compiled from literature reports, suitable for the development and benchmarking of peptide and prediction algorithms.
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2

Baláž, Štefan, Anton Kuchár, Ernest Šturdík, Michal Rosenberg, Ladislav Štibrányi, and Dušan Ilavský. "Interphase distribution of 2-furylethylenes." Collection of Czechoslovak Chemical Communications 50, no. 8 (1985): 1642–47. http://dx.doi.org/10.1135/cccc19851642.

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The distribution kinetics of 35 2-furylethylene derivatives in two-phase system 1-octanol-water was investigated. The transport rate parameters in direction water-1-octanol (l1) and backwards (l2) are partition coefficient P = l1/l2 dependent according to equations l1 = logP - log(βP + 1) + const., l2 = -log(βP + 1) + const., const. = -5.600, β = 0.261. Importance of this finding for assesment of distribution of compounds under investigation in biosystems and also the suitability of the presented method for determination of partition coefficients are discussed.
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3

Yang, Shi Ruo, and Dan Qing Chen. "Railway Steel Truss Coefficient of Lateral Force Distribution." Advanced Materials Research 304 (July 2011): 359–65. http://dx.doi.org/10.4028/www.scientific.net/amr.304.359.

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This paper illustrates the internal force calculation of the railway steel truss girder under the action of lateral load q by using the finite element method for truss segment. Load q is distributed with partition coefficients a1, a2 respectively on the top and bottom longitudinal bracing in conventional way and calculated as planar articulate. When two forces calculated respectively by using the spatial analysis and planar structure method are equal, lateral force distribution coefficient a1, a2 can be obtained. In the end of this paper we take examples of simple through beam of 48m, 64m, 80m, 144m, 192m, continuous through beam of 2×64m,3×64m, dual continuous deck beam of 2×64m and dual simple through beam of 64m and get the partition coefficient of the floor system plane, 0.77, and the other plane is 0.39.
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4

Schwarzenbach, R. P., and J. Westall. "Sorption of Hydrophobic Trace Organic Compounds in Groundwater Systems." Water Science and Technology 17, no. 9 (1985): 39–55. http://dx.doi.org/10.2166/wst.1985.0081.

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Factors influencing the subsurface sorption behavior of neutral and ionizable trace organic compounds are discussed. At equilibrium, the sorption of a neutral hydrophobic organic compound can be expressed by a simple partition coefficient. Partition coefficients, and thus retardation factors, may be estimated from the octanol/water partition coefficient of the compound and the organic carbon content of the aquifer material, if the organic carbon content exceeds 0.1%. For ionizable (anionic) hydrophobic compounds (represented by chlorinated phenols), the distribution ratio depends on both the pH and ionic strength of the aqueous phase, in contrast to the partitioning model for neutral compounds in which the composition of the aqueous phase is relatively unimportant.
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5

Berthod, Alain, and Nazim Mekaoui. "Distribution ratio, distribution constant and partition coefficient. Countercurrent chromatography retention of benzoic acid." Journal of Chromatography A 1218, no. 36 (2011): 6024–30. http://dx.doi.org/10.1016/j.chroma.2010.12.027.

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6

Aryani, Ni Luh Dewi. "PENETAPAN NILAI PARAMETER LIPOFILISITAS (LOG P, JUMLAH TETAPAN  HANSCH DAN TETAPAN f REKKER) ASAM PIPEMIDAT." Sains & Teknologi 1, no. 2 (2019): 17. http://dx.doi.org/10.24123/jst.v1i2.2224.

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Lipophilicity is the most often used physicochemical property in quantitative structure-activity relationships (QSAR) studies because it is related to the absorption across biological membrane and the distribution between body fluid and lipid-rich phase of drugs. Its quantitative descriptor is the octanol-water partition coefficient (usually expressed as log P). The 1-octanol-water partition coefficient of pipemidic acid was determined by an experimental using the shake-flask method and by calculating from p Hansch and f Rekker constant. The values of logarithmic intrinsic partition coefficient (IPC) and apparent partition coefficient (APC) of pipemidic acid were -2,03 ± 0,25 and -3,932 ± 0,25. The values of logarithmic partition coefficient, which were obtained by calculating of p Hansch and f Rekker constant were -1,65 and -1,981, respectively.
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7

Mäntylä, M., J. Perkkiö, and J. Heikkonen. "Partition Coefficient Ratios and Tumour Perfusion Studied with 85mKr and 133Xe." Nuklearmedizin 26, no. 06 (1987): 253–57. http://dx.doi.org/10.1055/s-0038-1628899.

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The relative partition coefficients of krypton and xenon, and the regional blood flow in 27 superficial malignant tumour nodules in 22 patients with diagnosed tumours were measured using the 85mKr- and 133Xe-clearance method. In order to minimize the effect of biological variables on the measurements the radionuclides were injected simultaneously into the tumour. The distribution of the radiotracers was assumed to be in equilibrium at the beginning of the experiment. The blood perfusion was calculated by fitting a two-exponential function to the measuring points. The mean value of the perfusion rate calculated from the xenon results was 13 ± 10 ml/(100 g-min) [range 3 to 38 ml/(100 g-min)] and from the krypton results 19 ± 11 ml/(100 g-min) [range 5 to 45 ml/(100 g-min)]. These values were obtained, if the partition coefficients are equal to one. The equations obtained by using compartmental analysis were used for the calculation of the relative partition coefficient of krypton and xenon. The partition coefficient of krypton was found to be slightly smaller than that of xenon, which may be due to its smaller molecular weight.
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8

Liu, Chi-Hsien, Hao-Che Chiu, Wei-Chi Wu, Soubhagya Laxmi Sahoo, and Ching-Yun Hsu. "Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution." Journal of Ophthalmology 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/304694.

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Topical delivery has the advantages including being user friendly and cost effective. Development of topical delivery carriers for lutein is becoming an important issue for the ocular drug delivery. Quantification of the partition coefficient of drug in the ocular tissue is the first step for the evaluation of delivery efficacy. The objectives of this study were to evaluate the effects of lipid nanoparticles and cyclodextrin (CD) on the corneal lutein accumulation and to measure the partition coefficients in the porcine cornea. Lipid nanoparticles combined with 2% HPβCD could enhance lutein accumulation up to209.2±18(μg/g) which is 4.9-fold higher than that of the nanoparticles. CD combined nanoparticles have 68% of drug loading efficiency and lower cytotoxicity in the bovine cornea cells. From the confocal images, this improvement is due to the increased partitioning of lutein to the corneal epithelium by CD in the lipid nanoparticles. The novel lipid nanoparticles could not only improve the stability and entrapment efficacy of lutein but also enhance the lutein accumulation and partition in the cornea. Additionally the corneal accumulation of lutein was further enhanced by increasing the lutein payload in the vehicles.
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9

Mochalski, Paweł, Julian King, Alexander Kupferthaler, Karl Unterkofler, Hartmann Hinterhuber, and Anton Amann. "Human Blood and Plasma Partition Coefficients for C4-C8 n-alkanes, Isoalkanes, and 1-alkenes." International Journal of Toxicology 31, no. 3 (2012): 267–75. http://dx.doi.org/10.1177/1091581812442689.

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Human blood:air and plasma:air partition coefficients for C4-C8 n-alkanes, isoalkanes, and 1-alkenes were determined using multiple headspace extraction coupled with solid phase microextraction and gas chromatography. Mean blood:air partition coefficients expressed in the form of dimensionless blood-to-air concentration ratio (g/mLb/g/mLa) were 0.183, 0.416, 1.08, 2.71, and 5.77 for C4-C8 n-alkanes; 0.079, 0.184, 0.473, 1.3, and 3.18 for C4-C8 isoalkanes; and 0.304, 0.589, 1.32, 3.5, and 7.01 for C4-C8 1-alkenes, respectively (n = 8). The reported partition coefficient values increased exponentially with boiling points, molecular weights, and the carbon atoms in the particle. The solubility of 1-alkenes in blood was higher than in plasma, whereas the blood:air and plasma:air partition coefficients of n-alkanes and isoalkanes did not differ significantly. Consequently, additional interactions of 1-alkenes with whole blood seem to occur. The presented findings are expected to be particularly useful for assessing the uptake, distribution, and elimination of hydrocarbons in human organism.
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10

Aliyu, Ahmed Sidi, Nuhu Musa Waziri, Hadiza Liman Mohammad, and Mohammed Abubakar Mohammed. "Partition behaviour of iron and zinc in the catchment alluvial sediments of River Gbako flood plains around Baddegi, central Bida basin, Nigeria." Scientia Bruneiana 18, no. 2 (2020): 32–39. http://dx.doi.org/10.46537/scibru.v18i2.94.

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Partition behaviors of iron (Fe) and zinc (Zn) were studied in the alluvial sediments of River Gbako floodplains around Baddegi using empirical formulas. The samples were cored from three pits locations (TR-1, TR-2, and TR-3). Particle size distribution and geochemical analysis were performed. Particle size distribution results indicated that the sediments are sand dominated. They have more than 50% sand with smaller percentages of clay and silt. Average partition coefficient values of Fe in the sediments are 1.02, 0.83, and 0.88 for TR-1, TR-2, and TR-3, respectively, and for Zn are 1.02, 0.95, and 0.83, for TR-1, TR-2 and TR-3, respectively. The average velocities of Fe mobilization in the sediments are 0.08 m/day, 0.07 m/day and 0.09 m/day for TR-1, TR-2 and TR-3, respectively, and for Zn mobilization are 0.07 m/day, 0.07 m/day and 0.09 m/day, for TR-1, TR-2, and TR-3, respectively. The metals were preferentially partitioned in the sediments than the water percolating through them, with average hydraulic conductivity (K) of 4.2 m/day. The partition behavior of the metals is used to explain contaminant transportation in the alluvial sediments of the River Gbako floodplains around Baddegi and the principle behind groundwater purification in the shallow alluvial aquifers of these floodplains.
 
 Index Terms: Partition coefficient, hydraulic conductivity, alluvial sediments, floodplain, Nigeria
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