Relevant bibliographies by topics / Dithane

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Dithane'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Dithane"

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Arya, Shashi Kiran, Ilika Ghosh, Ritesh Banerjee, and Anita Mukherjee. "Malathion and dithane induce DNA damage in Vicia faba." Toxicology and Industrial Health 33, no. 11 (September 26, 2017): 843–54. http://dx.doi.org/10.1177/0748233717726877.

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The increasing use of pesticides such as malathion and dithane in agriculture causes environmental mutagenicity. However, their genotoxicity in edible crops is seldom assessed. In this study, the genotoxic potential of malathion and dithane was evaluated in the roots of Vicia faba L. All three concentrations (0.05, 0.1, and 0.2%) of malathion and dithane tested resulted in a significant decrease in root length and inhibited seed germination. Cytological observations showed that the mitotic frequency in the root meristematic cells decreased parallel to the increase in concentrations, and the increase in chromosome aberrations and micronuclei frequency was concentration dependent. Alkaline comet assay revealed significant onset of DNA damage at all tested concentrations. For the randomly amplified polymorphic (RAPD)-polymerase chain reaction (PCR) analyses, 10 random RAPD primers were found to produce 116 unique polymorphic RAPD band fragments of 223–3139 bp. Each primer generated 3–15 RAPD bands on an average. The percentage of polymorphic DNA fragments was higher in malathion-exposed plants than dithane ones. The changes in RAPD profiles included disappearance and/or appearance of DNA bands in malathion and dithane treatment. Hence, DNA damage observed by the cytogenetic endpoints and comet assay corroborated with RAPD-PCR analysis. A total of 15 new protein bands of molecular weight ranging 11.894–226.669 kDa were observed in roots of Vicia plants that were exposed to the pesticides. The number of new protein bands was higher in malathion-treated DNA samples than in dithane-treated ones. Based on the results, we conclude that the pesticides can alter genomic template stability and change protein profiles. Malathion was more genotoxic than dithane. Therefore, RAPD assays can be useful in determining genotoxicity of pesticides in V. faba and other crops along with other quantitative parameters.
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Rokib, A., and MS Monjil. "Fungicidal seed treatment on germination and seedling vigour of lentil var. BINA Masur-3." Asian Journal of Medical and Biological Research 3, no. 1 (April 14, 2017): 140–44. http://dx.doi.org/10.3329/ajmbr.v3i1.32050.

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Effectiveness of six fungicides viz., Provax-200 (Carboxin+Thiram), Bavistin DF (Carbendazim), Dithane M-45 (Mancozeb), Secure (Mancozeb+Fenamidone), Antracol (propineb) and Daconil (Chlorothalonil) were evaluated to improve seed germination and seedling vigour of lentil variety BINA Masur-3. The experiment was conducted in the Green House of Seed Pathology Centre, Bangladesh Agricultural University, Mymensingh. Positive effect of seed treatment with fungicides on seed germination and seedling vigour of lentil was recorded. At 20 DAS, increased seed germination over control was observed in treated seeds with Deconil (10.40%) and Antracol (10.00%) followed by Dithane M-45 (7.20%). Seeds treated with Deconil and Dithane M-45 produced seedlings with higher shoot length, root length and seedling vigour. At 20 DAS, higher percent increased vigour index over control was found in Dithane M-45 (24.64%) and Deconil (22.44%), respectively.Asian J. Med. Biol. Res. March 2017, 3(1): 140-144
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Rai, I. Nyoman, I. Made Sudana, I. Nyoman Gede Astawa, and Rindang Dwiyani. "The effect of chopped corm sizes and types of soaking material on growth seedling of kepok banana (Musa paradisiaca L. ABB Kepok)." International journal of life sciences 4, no. 2 (July 20, 2020): 32–41. http://dx.doi.org/10.29332/ijls.v4n2.432.

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This research was conducted to study the effect of chopped corm sizes and types of soaking material on growth seedling of Kepok banana. The study was conducted at green house used a factorial randomized block design with 2 treatment factors. The first factor was chopped corm sizes (in length x width x height), consists of 3 levels i.e. small size 5 x 5 x 5 cm (B1), medium size 7 x 7 x 7 cm (B2), and large size 9 x 9 x 9 cm (B3). The second factor was types of soaking material, consists of 4 levels i.e. soaked in water only (R0), soaked with Dithane M-45 fungicide 2g/l (R1), soaked with Dithane M-45 fungicide 2 g/l + NAA hormone 100 ppm (R2), soaked with Dithane M-45 fungicide 2 g/l + BA hormone 75 ppm (R3), and soaked with the Dithane M-45 fungicide 2 g/l + NAA hormone 100 ppm + BA 75 ppm (R4).
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Vukovic, Slavica, Dusanka Indjic, and Sonja Gvozdenac. "Phytotoxic effects of fungicides, insecticides and nonpesticidal components on pepper depending on water quality." Pesticidi i fitomedicina 29, no. 2 (2014): 145–53. http://dx.doi.org/10.2298/pif1402145v.

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Modern agriculture relies on simultaneous application of fungicides, insecticides, fertilizers and adjuvants. The selection of compounds for tank-mixes has been rarely studied and it presents a risk in the application of pesticides but the quality of water should also be considered. The aim of this study was to assess the phytotoxic effects of several fungicides, insecticides, a complex fertilizer, an adjuvant and their mixtures on pepper (Capsicum annuum L.) as a test plant, depending on water quality. The effects of the pesticides: azoxystrobin (Quadris, 0.75 l/ha), mancozeb (Dithane M-70, 2.5 kg/ha), thiamethoxam (Actara 25-WG, 0.07 kg/ha) and cypermethrin (Cipkord EC-20, 0.3 l/ha), a complex fertilizer (Mortonijc plus /hereinafter: M+/ 3kg/ha), an adjuvant (Sillwet 77-L, 0.1 l/ha) and their mixtures, were assessed depending on the quality of water (well water - slightly alkaline, very hard and with high nitrite content; tap water - neutral and slightly hard; surface water - alkaline, slightly hard and with high content of nitrite and ammonia) using a puncture method. The effects were assessed after seven days by measuring the diameter of chlorosis and/or necrosis around puncture sites, and were expressed in mm2. The significance of differences between treatments was analyzed using a one-way ANOVA (LSD 0.05 %). In the slightly alkaline and very hard well water, all spray liquids containing Dithane M-70 caused a significant increase in leaf chlorosis area (from 6.0 to 25.2 mm2), compared to the control and other treatments. In the neutral and slightly hard tap water, all spray liquids containing Dithane M-70 caused a significant increase in leaf chlorosis (5.3 to 7.9 mm2) compared to the control and the other spray liquids, although its phytotoxicity in that water was at a lower level than it was in well water. However, in the weakly alkaline and slightly hard surface water from the river Sava, Dithane M-70, Dithane M-70 + Actara WG-25, Dithane M-70 + Sillwet L-77, and Dithane M-70 + Actara 25-WG + M+ showed a significant increase in phytotoxicity, compared to the control.
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PUSHPARAJ, VIVEK RAJ. "Cost effective and ex-situ (Seed Germination) conservation of Cullenia exarillata Robyns.an Endemic and Keystone species in Western Ghats, South India." International Journal of Advances in Scientific Research 1, no. 10 (December 30, 2015): 365. http://dx.doi.org/10.7439/ijasr.v1i10.2670.

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The Western Ghats is a chain of mountains and is one of the 33 recognized ecologically sensitive zones in the world. There are several centres of plant endemism and species richness within the Western Ghats. Cullenia exarillata Robyns is a large evergreen tree in the mid-elevation evergreen forests which is endemic to Western Ghats. This tree acts as a hot bed of activity when in flower and functions as a keystone resource for several species of arboreal mammals, including the endangered primate Lion tailed macaque and Nilgiri langur. A preliminary attempt is carried out to regenerate and restore the populations of C.exarillata. Seed germination studies were performed and seeds were treated using 3 different pre-sowing treatments. Seeds were soaked in Dithane-45 for 5minutes, in cow dung extract for two nights and in gibberillic acid (100 ppm) for 24 hours. Untreated seeds were also used as control. Dithane-45 treatment showed 80% seed germination and the cow dung extract treatment showed 20% seed germination. Dithane-45 treatment promotes speedy seed germination when compared to other treatments. Therefore, pre-sowing treatment with Dithane-45 for 5 minutes was more effective for this plant.
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Vieira, Alcílio, Carlos Ruggiero, and Sérgio Lucio David Marin. "Fitotoxicidade de fungicidas, acaricidas e inseticidas sobre o mamoeiro (Carica papaya L.) cultivar sunrise solo improved line 72/12." Revista Brasileira de Fruticultura 25, no. 1 (April 2003): 175–78. http://dx.doi.org/10.1590/s0100-29452003000100048.

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Estudaram-se os efeitos fitotóxicos de fungicidas, acaricidas e inseticidas e algumas associações entre eles, em plantas de mamoeiros (Carica papaya L.) cv. Sunrise Solo Improved Line 72/12, em condições de verão, no município de São Mateus - ES, localizado na região produtora do Estado. O experimento foi arranjado em delineamento de blocos casualizados, com 4 repetições e 03 plantas úteis por parcela experimental. Foram utilizados os seguintes produtos, com as respectivas doses, para cada 100 l de água: abamectin (Vertimec 18 CE - 50 ml); dicofol + tetradiphon (Carbax - 200 ml), fenbutatin oxide (Torque 500 SC - 60 ml); mancozeb (Dithane PM - 200g); oxicloreto de cobre (Reconil - 400g) e thiabendazole (Tecto 450 - 100ml). Analisou-se a fitotoxicidade dos produtos em relação à altura da planta, nº de folhas, número de flores e frutos ; diâmetro do caule e queimaduras ou injúrias foliares. As medições e contagens foram feitas um dia antes das pulverizações, 15 e 30 dias após. Constatou-se que o Vertimec 18 CE, associado ao Reconil ou ao Tecto 450, ocasionou leves injúrias foliares, detectadas aos 15 dias após as pulverizações, que se tornaram praticamente imperceptíveis, aos 30 dias após as pulverizações; e que Dithane PM, Reconil, Tecto 450, Carbax, Torque 500 SC, Dithane PM + Carbax, Dithane PM + Torque 500 SC, Dithane PM + Vertimec 18 CE, Reconil + Carbax, Reconil + Torque 500 SC, Tecto 450 + Carbax e, Tecto 450 + + Torque 500 SC não interferiram nos parâmetros de desenvolvimento e de produção estudados, bem como não causaram injúrias ou queimaduras nas folhas dos mamoeiros.
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Barczyński, Stanisław, Zofia Machowicz-Stefaniak, and Piotr Sobiczewski. "The effect of selected fungicides on survival of Agrobacterium tumefaciens in various kinds of soils." Acta Agrobotanica 55, no. 1 (2013): 27–39. http://dx.doi.org/10.5586/aa.2002.003.

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The effect of 10 fungicides on survival of A. tumefaciens in various types of soils was studied. In fertile, nonsterile soil Dithane M-45 (mancozeb), Euparen 50 WP (tolyfluanid), Kaptan 50 WP (captan) and Ridomil Gold 80 WP (metalaxyl) at concentration of 1000 ppm showed the highest antibacterial activity. Similar trends in activity of these fungicides occurred in fertile, sterile soil, however a little lower in case of Kaptan and Euparen. In most of investigated soils Befran 25 SL (imimnoctadyne), Syllit 65 WP (dodine) and Thiram Granulfo 80 WG (thiram) increased bacteria number. In sandy acidic soil (pH 3,5) all tested fungicides totally eliminated bacteria. On the other hand in sandy neutral soil only Dithane, Euparen, Kaptan and Ridomil showed such activity. Ten fold decrease of fungicides concentration generally did not influence Kaptan and Ridomil effectiveness but it decreased the activity of Dithane and Euparen.
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Khan, A. A., K. U. Sarker, M. F. Hossain, M. M. Haque, and I. H. Mian. "Pre-Storage Fungicidal Treatment Effects on Prevalence of Seed-Borne Fungi and Quality of Onion (Allium cepa L.) Seed." Agriculturists 15, no. 2 (January 26, 2018): 52–58. http://dx.doi.org/10.3329/agric.v15i2.35464.

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Effect of pre-storage fungicidal treatment on prevalence of seed-borne fungi and quality of onion (Allium cepa L.) seeds was evaluated under laboratory condition. Seeds were treated separately with five fungicides namely Bavistin 50 WP (Carbendazim) and Dithane M-45 (Mancozeb) @ 2.2 g/kg, Homai (Thiophanate) and Rovral (Iprodione) @ 2.0 g/kg and Provax-200 (Carboxin) @ 3.0 g/kg of seeds before storage. Prevalence of seed-borne fungi, percent seeds germination and vigor index were evaluated just before storage, 75 and 150 days after storage. Fungicides produced significant negative impact on seed-borne fungi and positive impact in maintaining quality during storage. Provax-200, Rovral, Dithane M-45 and Bavistin effectively reduced seed-borne fungi and performed better for germination and vigor of seeds. Seed treatment with Provax-200, Rovral, Bavistin or Dithane M-45 would therefore be suggested as effective fungicides to control seed-borne fungal infection and maintain better germination and vigor of onion seed in storage.The Agriculturists 2017; 15(2) 52-58
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Karimova, N. M., L. P. Kuzina, and O. V. Kil'disheva. "1,4-dithane-2,5-dicarboxylic acid." Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 34, no. 11 (November 1985): 2437–39. http://dx.doi.org/10.1007/bf00956824.

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Várnagy, L., P. Budai, and E. Molnár. "One-generation reproduction toxicity study of Dithane M-45 (mancozeb) and lead acetate." Acta Veterinaria Hungarica 50, no. 3 (July 1, 2002): 365–71. http://dx.doi.org/10.1556/avet.50.2002.3.12.

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The reproductive toxicity of lead acetate and of a fungicide formulation (Dithane M-45) containing 80% mancozeb was studied on rats. Lead acetate was applied in the feed in the following dose groups: control, 1,000, 5,000 and 10,000 mg/kg of diet. The three treatment groups received, in addition to the above doses of lead acetate, 4,500 mg/kg Dithane M-45 in the diet. The method was based on the OECD Guideline for Testing of Chemicals No. 415 (1981). Clinical symptoms and mortality were not found in the parent generation. The body weight of female animals decreased significantly before the pregnancy period. This tendency was also seen in males after the combination treatment. At the two high dose levels a remarkable body weight increase was seen in the female animals during the lactation period. As a result of treatment, decreased body weight of offspring was measured during the lactation period. No gross pathological changes were seen. Histological examination showed general tubulonephrosis in the experimental animals. It can be established that the administration of Dithane M-45 did not enhance the reproductive toxicity of lead acetate.
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Dissertations / Theses on the topic "Dithane"

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Williams, Nadia. "An investigation into the parameters affecting the stability of Dithane." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/645.

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Plant diseases caused by fungi are the number one cause of crop loss worldwide. The application of a fungicide which is a toxic substance applied either to prevent the growth of, or to kill fungi is one of the methods by which plant diseases are controlled. Ethylenebisdithiocarbamate fungicides are a group of surface acting fungicides which control a broad spectrum of fungi and their associated plant diseases. Mancozeb, also commonly known as Dithane, falls under the polymeric Dithiocarbamate fungicides which have several sites of toxicity to the fungal cell. The use of Mancozeb as a fungicide is increasing worldwide due to the advantages of low acute toxicity, low production and short environmental persistence. However, it has one major disadvantage, namely its lack of oxidative stability under ambient conditions. One of the objectives of this study was to characterize the Dithane samples supplied by Dow AgroSciences in terms of their active ingredient, metal and stabilizer content, and to study the thermal decomposition behaviour of Dithane. An attempt was made to correlate the active ingredient analyses with the TGA and DSC results to establish whether the thermal stability and active ingredient content of Dithane could be simultaneously determined by thermal analysis. This approach offered the attractive advantage of shorter analysis times thus allowing the elimination of the more tedious analytical methods employed by Dow AgroSciences. Furthermore, Fourier Transform infra-red characterization of Dithane samples and metal complexes containing HMT, Mn and/or Zn was carried out in order to identify the presence of functional groups and to gain some insight into the nature of the bonding of HMT, sulfate and water. A study of the nature of the bands in the FTIR spectra of these complexes was able to highlight the nature of the bonding but could not give confirmation of the structures of these complexes. In addition to this, the amount of HMT present in the said complexes was determined by the FTIR using the standard addition method. A final objective of the study was to investigate the reconstitution of Dithane by investigating the influence of the addition order of the various constituents on the stability of the final product. The addition order was found to have a definite influence on the thermal stability of the final product as well as on the percentage of fixed HMT in the product, and the kinetics of the Mn/Zn exchange.
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Klair, Sukhbinder S. "Stereoselective enolate alkylation of acyl dithiane oxides." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314512.

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Allin, Steven M. "Applications of 1,3-dithiane 1-oxide asymmetric building block." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357285.

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Westwood, Donald. "An approach to asymmetric synthesis using 1,3-dithiane derivatives." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316685.

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Milsom, Greig. "Synthetic approaches to the asymmetric synthesis of #alpha#-keto and #beta#-hydroxy esters." Thesis, Kingston University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285949.

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Franklin, Richard. "Trans-1,3-dithiane-1,3-dioxide, a chiral carbonyl anion equivalent." Thesis, University of Bath, 1993. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357289.

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Prodger, Jeremy C. "Stereoselective reactions controlled by the 1,3-dithiane 1-oxide building block." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291877.

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Purdie, Mark. "Stereoselective control by the 1,3-dithiane 1-oxide asymmetric building block." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262490.

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Wilkes, Robin David. "The preparation and applications of optically enriched 1,3-dithiane 1-oxides." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240840.

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Millar, Andrea P. "Synthetic applications of, and biological approaches to 1,3-dithiane 1-oxides." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365907.

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Books on the topic "Dithane"

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Zakhmi, Barinder Singh. Akhin ditha Lebanon. Leeds: [s.n.], 1992.

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Nāzu, Sanāʼī, Sanāʼī Nāzu, and Sanāʼī Nāzu, eds. Mūn sī d̤iṭhā māʼu: Yādgīriyūn, k̲h̲ākā = Moon say ditha maou : memories and skeches. Ḥaidarābād, Sindh: Sindhī Sāhata Gharu, 2015.

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Ghlinn, Áine Nı́. Daoine agus dithe. An Gm, 1995.

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Koca Rajabamsira Kamatapura: Sapona, dithaka ne mantho itihasa. Guwāhāṭi: Blu Spera' Bukac, 2015.

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Asinger, Dr Friedrich. Synthesen und Reaktionsfähigkeit von 2.5-Endoxi- und 2.5-Endimino-1.4-Dithianen ... des Landes Nordrhein-Westfalen ). VS Verlag für Sozialwissenschaften, 2013.

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Book chapters on the topic "Dithane"

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Kuhlman, Thomas Scheby. "Dithiane." In Springer Theses, 99–103. Heidelberg: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-00386-3_9.

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Salan, J. "From 1,3-Dithiane." In Ketones, 1. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-026-00400.

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Sato, R., and T. Kimura. "1,2-Dithianes." In Sulfur, Selenium, and Tellurium, 1. Georg Thieme Verlag KG, 2008. http://dx.doi.org/10.1055/sos-sd-039-01107.

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Whitehead, A., S. R. Sieck, S. Mukherjee, and P. R. Hanson. "Dithiane Alkylation, Followed by Hydrolysis." In Three Carbon-Heteroatom Bonds: Esters and Lactones; Peroxy Acids and R(CO)OX Compounds; R(CO)X, X=S, Se, Te, 1. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-021-00915.

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Parrain, J. L., and J. Thibonnet. "Enolates Bearing α-Dithiane Sulfoxides." In Ketones, 1. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-026-00738.

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Aitken, R. A., and K. M. Aitken. "Using 1,3-Dithianes." In Nitro, Nitroso, Azo, Azoxy, and Diazonium Compounds, Azides, Triazenes, and Tetrazenes, 1. Georg Thieme Verlag KG, 2010. http://dx.doi.org/10.1055/sos-sd-041-00302.

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Anderson, E. A., and B. Gockel. "Variation 1: Using Dithiane-Stabilized Carbanions." In Science of Synthesis Knowledge Updates KU 2011/1, 1. Georg Thieme Verlag KG, 2010. http://dx.doi.org/10.1055/sos-sd-129-00065.

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Kosarev, S. A. "Synthesis from 1,4-Dithiane-2,5-diol." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-116-00706.

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Taber, Douglass F. "The Thomson Synthesis of (–)-GB17." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0096.

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(–)-GB17 3 is one of the Galbulimima alkaloids, a family that shows a wide range of interesting physiological activity. Regan J. Thomson of Northwestern University devised (Angew. Chem. Int. Ed. 2012, 51, 2481) a convergent assembly of 3, a key step of which was the intramolecular Michael cyclization of 1 to 2. The hydroxy aldehyde 6 was prepared by alkylation of the dithiane 4 with 5, followed by hydrolysis. The preparation of 9, by condensation of 8 with 7 followed by hydrogenation and protection, had been reported by Lhommet. Condensation of 9 with the linchpin reagent 10 gave an intermediate keto phosphonate, which was combined with 6 to give, after oxidation, the aldehyde 1. Two new stereogenic centers are created in the course of the cyclization of 1. The authors found that the TFA salt 11 of the Hayashi catalyst delivered 2 with high diastereocontrol. Control experiments showed that the buttressing effect of the dithiane was required for the cyclization. The authors then explored the next intramolecular Michael cyclization of 13 to 14. In this cyclization, the stereogenic center at 6 is in jeopardy by elimination and readdition. Cyclization of the trans unsaturated ester led to the wrong diastereomer of 14, but cyclization of the cis ester 13, prepared by the Still-Gennari protocol, cleanly gave the desired diastereomer. The reaction worked best with the free amine. Under the conditions of the reaction the Michael addition product spontaneously cyclized to the lactam 14. The ketone of 14 was selectively enolized, then converted to its enol triflate, which under Pd-mediated reduction gave the alkene 15. Alkylation of 15 with 16 predominantly gave the diene 18. Hydrolysis of the dithiane to the ketone followed by reduction gave mainly the desired equatorial alcohol, which was cleaved oxidatively to (–)-GB17 3. Although there have been many isolated reports of the utility of intramolecular Michael addition as a synthetic method, there has been little systematic investigation. The optimization studies that are the heart of this work are a welcome addition.
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Sato, R. "Oxidation of 1,4-Dithianes." In Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00119.

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Conference papers on the topic "Dithane"

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Ju, Johnny, Jae G. Kim, Jangwoen Lee, Sari Mahon, Daniel Lemor, Steven Patterson, and Matt Brenner. "3- Mercaptopyruvate Dithiane In The Treatment Of Cyanide Toxicity In A Rabbit Model." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4557.

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Jamaluddin, Moideen P., C. Sreedevi, Ancy Thomas, and Lissy K. Krishnan. "A MOLECULAR MECHANISM FOR THE DITHI0THREIT0L-MEDIAT5D PLATELET AGGREGATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644495.

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Biochemical mechanisms of stimulus response coupling is an intricate problem in platelet biochemistry. Recently we obtained evidence that support the view that conformational changes of an (unsaturated fatty acid – and U46619-binding) haemoprotein induced by the binding of arachidonic acid, H2O2 or PGH2 liberated in apparently different platelet compartments in response to different stimuli could constitute a mechanism (L.K. Krishnan … M.P. Jamaluddin, FEBS Lett, in the press). We investigated the effect of dithiothreitol (DTT), a platelet agonist whose mechanism of action is unknown, on the purified haemoprotein. DTT was found by spectral measurements and gelfiltration experiments to bring about a slow time-dependent conformational .change and oligomerization of the protein concomitantly with its oxidation. Oxidised DTT (trans-4,5-dihy-droxy-1,2-dithiane) was found to induce a similar conformational change by binding to the protein (halfsaturation cancn. 2 mM). Oligomerization changed the charge characteristics of the protein, from net positive to net negative, ait pH 7.4. Protein-protein association is associated with large volume increases. Excluded volume effects and changes in charge distribution at the side of protein conformational change could trigger actin polymerization, pseudopod formation and aggregation, modulated by protein phosphorylation and Ca2+ concentration. In conformity with these ideas oxidized DTT near its half-maximal saturation concentration for the protein, was found to aggregate gelfiltered calf platelets. Presumably it functions as a thioanalogue of PGH2. Oxidized glutathione or oxidized 2-mercaptoethanol could also bring about protein conformational change and platelet aggregation.
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Kim, Jae G., Jangwoen Lee, Sari Mahon, Daniel Lemor, Bruce J. Tromberg, Steven Patterson, and Matt Brenner. "Differential Effects Of The Novel Cyanide Antidote, 3-Mercaptopyruvate Dithiane, On Brain And Muscle Tissue In The Treatment Of Cyanide Toxicity In A Rabbit Model." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4584.

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Chen, Ziqiu, Daniel Zindel, Georg Seyfang, Martin Quack, Lubos Horny, Csaba Fábri, Irina Bolotova, and Sieghard Albert. "HIGH RESOLUTION GHZ AND THZ (FTIR) SPECTROSCOPY AND THEORY OF PARITY VIOLATION AND TUNNELING FOR 1,2-DITHIINE (C4H4S2) AS A CANDIDATE FOR MEASURING THE PARITY VIOLATING ENERGY DIFFERENCE BETWEEN ENANTIOMERS OF CHIRAL MOLECULES." In 71st International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2016. http://dx.doi.org/10.15278/isms.2016.fa06.

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