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Journal articles on the topic 'Diversité alpha et beta'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Tsuji, Y., M. Tamai, S. Morimoto, et al. "AB1232 ORAL DYSBIOSIS REFLECTS THE IMMUNOLOGICAL ALTERATION OF RA REGARDING TO ACPA AND HLA DRB1*SE: NAGASAKI ISLAND STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1907.2–1907. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5147.

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Background:Anti-citrullinated protein antibody (ACPA) production is observed in several organs even prior to the onset of rheumatoid arthritis (RA), and oral mucosa is considered to be one of the important tissues. The presence of HLA-DRB1*SE closely associates with ACPA production. Saliva is considered to reflect the oral microbiota including periodontal disease. Alteration of oral microbiota of RA becomes to be normalized by DMARDs treatment, however, the interaction of HLA-DRB1*SE, ACPA and oral microbiota of RA patients remains to be elucidated.Objectives:The Nagasaki Island Study, which h
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2

Raes, Eric J., Levente Bodrossy, Jodie van de Kamp, et al. "Oceanographic boundaries constrain microbial diversity gradients in the South Pacific Ocean." Proceedings of the National Academy of Sciences 115, no. 35 (2018): E8266—E8275. http://dx.doi.org/10.1073/pnas.1719335115.

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Marine microbes along with microeukaryotes are key regulators of oceanic biogeochemical pathways. Here we present a high-resolution (every 0.5° of latitude) dataset describing microbial pro- and eukaryotic richness in the surface and just below the thermocline along a 7,000-km transect from 66°S at the Antarctic ice edge to the equator in the South Pacific Ocean. The transect, conducted in austral winter, covered key oceanographic features including crossing of the polar front (PF), the subtropical front (STF), and the equatorial upwelling region. Our data indicate that temperature does not de
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3

Song, W. K., W. Wang, H. Sato, D. A. Bielser, and S. J. Kaufman. "Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases." Journal of Cell Science 106, no. 4 (1993): 1139–52. http://dx.doi.org/10.1242/jcs.106.4.1139.

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We recently reported the cloning and sequencing of the alpha 7 integrin chain and its regulated expression during the development of skeletal muscle (Song et al. (1992) J. Cell Biol. 117, 643–657). The alpha 7 chain is expressed during the development of the myogenic lineage and on adult muscle fibers and this suggests that it participates in multiple and diverse functions at different times during muscle development. One interesting portion of this isoform is its cytoplasmic domain; comprised of 77 amino acids it is the largest in the alpha chains thus reported. In these experiments we begin
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4

Teyssier, Corinne, Hélène Marchandin, and Estelle Jumas-Bilak. "Le génome des alpha-protéobactéries : complexité, réduction, diversité et fluidité." Canadian Journal of Microbiology 50, no. 6 (2004): 383–96. http://dx.doi.org/10.1139/w04-033.

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The alpha-proteobacteria displayed diverse and often unconventional life-styles. In particular, they keep close relationships with the eucaryotic cell. Their genomic organization is often atypical. Indeed, complex genomes, with two or more chromosomes that could be linear and sometimes associated with plasmids larger than one megabase, have been described. Moreover, polymorphism in genome size and topology as well as in replicon number was observed among very related bacteria, even in a same species. Alpha-proteobacteria provide a good model to study the reductive evolution, the role and origi
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5

Alachkar, Houda, Poh-Yin Yew, Rui Yamaguch, et al. "Characterization of Tcra and Tcrb Repertoires in Acute Myeloid Leukemia Patients before and after Combined Haploidentical and Umbilical Cord Blood Transplant." Blood 124, no. 21 (2014): 2503. http://dx.doi.org/10.1182/blood.v124.21.2503.2503.

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Abstract Rationale: Allogeneic hematopoietic stem cell transplantation (HSCT) remains the most effective therapy for patients with acute myeloid leukemia (AML). The graft-versus-leukemia effect (GVL), mediated by the engrafted T lymphocytes targeting leukemic cells, is thought to play an important role in affecting the overall outcome of patients with AML. Umbilical cord blood (UCB) has emerged as an alternative and effective source of hematopoietic stem cells in high risk patients. We previously reported the hematopoietic reconstitution and clinical outcomes in 45 patients undergoing haplo-co
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6

D'Angelo, Christopher, Sailendharan Sudakaran, Peiman Hematti, et al. "Impact of Antibiotics on Gut Microbiota Diversity and the Results of a Prospective Dietary Assessment in Patients with Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 4653. http://dx.doi.org/10.1182/blood-2019-123530.

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Introduction: The gut microbiome is an important mediator of the host immune system, and studies in allogeneic transplantation demonstrate that loss of microbiome diversity is associated with inferior outcomes (Taur et al, Blood 2014). Loss of gut microbial diversity following autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients has been associated with reductions in progression-free survival but lacks clear validation from independent transplant centers, and the factors driving these changes are poorly understood (Khan et al, Blood 2018). Evidence from non-oncologic s
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7

Dehennin, L. "Detection of simultaneous self-administration of testosterone and epitestosterone in healthy men." Clinical Chemistry 40, no. 1 (1994): 106–9. http://dx.doi.org/10.1093/clinchem/40.1.106.

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Abstract Combined self-administration of testosterone (T) and epitestosterone (ET) by athletes counteracts the efficiency of the corresponding urinary glucuronides (G) ratio, (T/ET)G, as an indicator of T abuse. I therefore propose 5-androstene-3 beta, 17 alpha-diol (5A3 beta 17 alpha), the immediate metabolic precursor of ET, as a new reference compound for the expression of relative excretions of T and ET. Thus (T/5A3 beta 17 alpha)G and (ET/5A3 beta 17 alpha)G become potential criteria to indicate joint administration of T and ET, since their respective threshold values (2.5 and 1.5) are ex
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8

Ong, Michelle Shuling, and Vinay Tergaonkar. "When alpha meets beta, mast cells get hyper." Journal of Experimental Medicine 216, no. 10 (2019): 2229–30. http://dx.doi.org/10.1084/jem.20191169.

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The evolutionary conservation of the catalytically inactive α-tryptase gene has remained a mystery. In this issue of JEM, Le et al. (2019. J. Exp. Med. https://doi.org/10.1084/jem.20190701) unveil the existence of a novel but natural tryptase, heteromeric α/β-tryptase, a critical mediator of α-tryptase–associated diseases.
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9

NASTASE, D. "Les débuts de l'Eglise moldave et le siège de Constantinople par Bajazet Ier." BYZANTINA SYMMEIKTA 7 (September 29, 1987): 205. http://dx.doi.org/10.12681/byzsym.717.

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  <p>Δ. Ναστάσε</p><p>  Oἱ ἀπαρχὲς τῆς Μολδαβικῆς Ἐκκλησίας καὶ ἡ πολιορκία τῆς Κωνστα&nu
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10

Jaunin, P., F. Jaisser, A. T. Beggah, et al. "Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps." Journal of Cell Biology 123, no. 6 (1993): 1751–59. http://dx.doi.org/10.1083/jcb.123.6.1751.

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The ubiquitous Na,K- and the gastric H,K-pumps are heterodimeric plasma membrane proteins composed of an alpha and a beta subunit. The H,K-ATPase beta subunit (beta HK) can partially act as a surrogate for the Na,K-ATPase beta subunit (beta NK) in the formation of functional Na,K-pumps (Horisberger et al., 1991. J. Biol. Chem. 257:10338-10343). We have examined the role of the transmembrane and/or the ectodomain of beta NK in (a) its ER retention in the absence of concomitant synthesis of Na,K-ATPase alpha subunits (alpha NK) and (b) the functional expression of Na,K-pumps at the cell surface
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11

Adachi, Y., H. Inufusa, M. Yamashita, et al. "Clinical application of serum bilirubin fractionation by simplified liquid chromatography." Clinical Chemistry 34, no. 2 (1988): 385–88. http://dx.doi.org/10.1093/clinchem/34.2.385.

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Abstract Serum bilirubin was fractionated by a new reversed-phase "high-performance" liquid-chromatographic (HPLC) procedure, on Micronex RP-30, a polyacryl ester. The five fractions were: delta (delta-bilirubin, B delta), gamma (bilirubin diglucuronide, BDG), beta (bilirubin monoglucuronide, BMG), beta' [(Z,E)- and (or) (E,Z)-bilirubin IX alpha], and alpha [(Z,Z)-bilirubin IX alpha]. We found close correlation with results of the modified HPLC fractionation of Lauff et al. (J Chromatogr 1981;226:391-402), except for the beta' fraction, which was eluted after beta. The Micronex HPLC involves a
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12

Hoang, Huy N., Timothy A. Hill, Gloria Ruiz-Gómez, et al. "Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides." Chemical Science 11, no. 28 (2020): 7511. http://dx.doi.org/10.1039/d0sc90138e.

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13

NASTASE, D. "La chronique de Jean Chortasménos et le dernier siècle d᾽historiographie byzantine." BYZANTINA SYMMEIKTA 8 (September 29, 1989): 389. http://dx.doi.org/10.12681/byzsym.734.

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  <p>Δ. Ναστάσε</p><p>Τὸ χρονικὸ τοῦ Ἰωάννη Χορτασμένου καὶ ὁ τελευταῖος αἰώνας τῆς βυζ&alp
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14

Sun, D. Y., J. Z. Guo, H. A. Hartmann, H. Uno, and L. E. Hokin. "Differential expression of the alpha 2 and beta messenger RNAs of Na,K-ATPase in developing brine shrimp as measured by in situ hybridization." Journal of Histochemistry & Cytochemistry 40, no. 4 (1992): 555–62. http://dx.doi.org/10.1177/40.4.1313064.

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We used in situ hybridization histochemistry with synthetic oligonucleotide probes to localize the mRNAs encoding the alpha 2- and beta-mRNAs of Na,K-ATPase during development of the brine shrimp Artemia. The mRNAs of the alpha 2- and beta-subunit were of low abundance in the cysts; in addition, less mRNA of the beta-subunit was localized. During emergence (12 hr), there was an increase in alpha 2-subunit mRNA in the gut mucosa, but there was a burst in beta-subunit mRNA throughout. As development progressed, the mRNAs of both the alpha 2- and beta-subunits showed a distinct pattern of express
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15

Gu, M., W. Wang, W. K. Song, D. N. Cooper, and S. J. Kaufman. "Selective modulation of the interaction of alpha 7 beta 1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation." Journal of Cell Science 107, no. 1 (1994): 175–81. http://dx.doi.org/10.1242/jcs.107.1.175.

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The alpha 7 beta 1 integrin was originally identified and isolated from differentiating skeletal muscle and shown to be a laminin-binding protein (Song et al. (1992) J. Cell Biol. 117, 643–657). Expression of the alpha 7 gene and protein are developmentally regulated during skeletal muscle differentiation and have been used to identify cells at distinct stages of the myogenic lineage (George-Weinstein et al. (1993) Dev. Biol. 156, 209–229). The lactoside-binding protein L-14 exists as a dimer and has been localized on a variety of cells, in association with extracellular matrix. During myogene
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16

Galanello, Renzo, Serena Sanna, Lucia Perseu, et al. "Genetic Modifiers of Homozygous Beta Zero Thalassemia." Blood 112, no. 11 (2008): 1874. http://dx.doi.org/10.1182/blood.v112.11.1874.1874.

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Abstract Introduction: Extensive studies over the last 50 years have derived two major modifiers of the clinical expression of beta-thalassemia: innate ability to produce fetal hemoglobin (Hb F) and co-inheritance of alpha-thalassemia. Recently genetic variants at the BCL11A locus and HBS1L-MYB intergenic region, that can modulate Hb F levels have been identified ( Thein et al 2007, Menzel et al 2007). Moreover, BCL11A variant has been shown to moderate the phenotype of homozygous beta-thalassemia (Uda et al 2008). In this study we evaluated the contribution of these Hb F modulating genetic ma
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17

Castro-Medina, F., S. R. Mohali, J. R. Úrbez-Torres, and W. D. Gubler. "First Report of Lasiodiplodia pseudotheobromae Causing Trunk Cankers in Acacia mangium in Venezuela." Plant Disease 98, no. 5 (2014): 686. http://dx.doi.org/10.1094/pdis-02-13-0160-pdn.

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In May 2010, canker and wood stain symptoms in trunks and stems of 125 Acacia mangium were observed during a survey conducted in the Uverito plantations, Monagas State, Venezuela. Cankers were 20 to 65 cm long and were brownish on the margins and dark brown in the center. Many of the cankers had swollen margins and in some cases a black exudate could be seen leaking from the most severe cankers. Small pieces (4 to 5 mm) of necrotic tissues from the cankers were surface sterilized for 1 min in 1.5% NaOCl, washed twice with sterile distilled water, and plated onto potato dextrose agar amended wi
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18

Galanello, Renzo, Stefania Satta, Maria Dolores Cipollina, Chiara Perra, and Luciana Perseu. "AHSP Promoter Homopolymer in Beta-Thalassemia Syndromes." Blood 108, no. 11 (2006): 3821. http://dx.doi.org/10.1182/blood.v108.11.3821.3821.

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Abstract Alpha hemoglobin stabilizing protein (AHSP) is an erythroid protein that binds specifically to the alpha globin chains to form a stable complex, preventing their precipitation before the assembly of the hemoglobin tetramere. Studies have shown that AHSP is required for normal erythropoiesis, knock-out mice has a phenotype similar to beta thalassemia, loss of AHSP worsens the severity of the disease in thalassemic mice. Therefore, altered AHSP expression or function could account for some of the variability in beta-thalassemia phenotype. At position -160bp upstream of exon 1 of the AHS
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19

Tang, M. J., and A. A. McDonough. "Low K+ increases Na(+)-K(+)-ATPase alpha- and beta-subunit mRNA and protein abundance in cultured renal proximal tubule cells." American Journal of Physiology-Cell Physiology 263, no. 2 (1992): C436—C442. http://dx.doi.org/10.1152/ajpcell.1992.263.2.c436.

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Studies from this laboratory demonstrate that LLC-PK1/Cl4 cells, a cultured renal cell line, respond to incubation in low-K+ medium by coordinately increasing abundance of both alpha- and beta-subunits of Na(+)-K(+)-ATPase but increase only beta- and not alpha-mRNA levels (Lescale-Matys et al. J. Biol. Chem. 265: 17935-17940, 1990) and that alpha-abundance is likely increased as a result of increased efficiency of alpha-mRNA translation (L. Lescale-Matys and A. A. McDonough. J. Cell Biol. 111: 311A, 1990). The aim of this report was to determine if nontransformed kidney cells would respond to
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20

Pachter, J. A., R. Mayer-Ezell, R. M. Cleven та A. B. Fawzi. "Endothelin (ETA) receptor number and calcium signalling are up-regulated by protein kinase C-β 1 overexpression". Biochemical Journal 294, № 1 (1993): 153–58. http://dx.doi.org/10.1042/bj2940153.

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To evaluate the role of protein kinase C (PKC) in regulation of cellular responsiveness to mitogens, we used rat 6 (R6) fibroblasts that stably overexpress the beta 1 isoenzyme of protein kinase C (PKC-beta 1). The potent vasoconstrictor and mitogen endothelin-1 (ET-1; 100 nM) was substantially more effective in stimulating InsP3 accumulation in PKC-beta 1-overexpressing fibroblasts (PKC3 cells) than in control fibroblasts lacking the PKC-beta 1 cDNA insert. PKC3 cells were found to express a 7-fold greater number of endothelin receptors than did control cells, whereas both cell lines showed e
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21

Zanetti, A., G. Conforti, S. Hess, et al. "Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane." Blood 84, no. 4 (1994): 1116–23. http://dx.doi.org/10.1182/blood.v84.4.1116.1116.

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Abstract In previous work (Conforti et al, Blood 80:437, 1992), we have shown that integrins in endothelial cells (EC) are not polarized to the basal cell membrane, but are also exposed on the apical cell surface, in contact with blood. Therefore, endothelial integrins might be available for binding circulating plasma proteins. However soluble plasma vitronectin (vn) bound very poorly to EC apical surface and this interaction was unaffected by Arg-Gly-Asp (RGD) peptides or an anti- alpha v beta 3 serum. In contrast, beads (diameter, 4.5 microns) coupled with plasma vn associated to EC apical s
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22

Zanetti, A., G. Conforti, S. Hess, et al. "Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane." Blood 84, no. 4 (1994): 1116–23. http://dx.doi.org/10.1182/blood.v84.4.1116.bloodjournal8441116.

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In previous work (Conforti et al, Blood 80:437, 1992), we have shown that integrins in endothelial cells (EC) are not polarized to the basal cell membrane, but are also exposed on the apical cell surface, in contact with blood. Therefore, endothelial integrins might be available for binding circulating plasma proteins. However soluble plasma vitronectin (vn) bound very poorly to EC apical surface and this interaction was unaffected by Arg-Gly-Asp (RGD) peptides or an anti- alpha v beta 3 serum. In contrast, beads (diameter, 4.5 microns) coupled with plasma vn associated to EC apical surface in
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23

McDonough, A. A., C. E. Magyar, and Y. Komatsu. "Expression of Na(+)-K(+)-ATPase alpha- and beta-subunits along rat nephron: isoform specificity and response to hypokalemia." American Journal of Physiology-Cell Physiology 267, no. 4 (1994): C901—C908. http://dx.doi.org/10.1152/ajpcell.1994.267.4.c901.

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The activity of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase), the sodium pump, which drives active Na+ reabsorption along the nephron, varies over an order of magnitude, depending on the nephron segment, and activity is increased in the outer medullary collecting tubule (MCT) during hypokalemia. The aims of the present study were to assess abundance of sodium pump alpha 1- and beta 1-subunits in dissected nephron segments of the rat by immunoblotting, to determine if alpha 2- or alpha 3-protein could be detected in the collecting tubules, as suggested by Barlet-Bas et al. (C. Barlet-
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24

Petrenko, Volodymyr, Camille Saini, Laurianne Giovannoni, et al. "CO-52: Rôles de l'horloge circadienne dans la fonction des cellules alpha et beta d'îlot pancréatique murine et humain." Diabetes & Metabolism 42 (March 2016): A16. http://dx.doi.org/10.1016/s1262-3636(16)30070-2.

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25

Simon-Assmann, P., C. Leberquier, N. Molto, T. Uezato, F. Bouziges, and M. Kedinger. "Adhesive properties and integrin expression profiles of two colonic cancer populations differing by their spreading on laminin." Journal of Cell Science 107, no. 3 (1994): 577–87. http://dx.doi.org/10.1242/jcs.107.3.577.

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The mostly undifferentiated parental HT29 (HT29p) human colonic adenocarcinoma cell line and a differentiated subpopulation selected by the anti-cancer drug 5-fluorouracil (HT29-Fu) (Lesuffleur et al. (1991) Int. J. Cancer 49, 721–730) display strikingly different behavior when grown on laminin coatings: the former grows as aggregates while the latter grows as monolayers. In an attempt to explain this difference, we performed a comparative study of cell adhesion properties and of expression, involvement and localization of the alpha 6, beta 1 and beta 4 subunits constituting the integrin famil
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26

Chang, M., Y. Suen, SM Lee, et al. "Transforming growth factor-beta 1, macrophage inflammatory protein-1 alpha, and interleukin-8 gene expression is lower in stimulated human neonatal compared with adult mononuclear cells." Blood 84, no. 1 (1994): 118–24. http://dx.doi.org/10.1182/blood.v84.1.118.118.

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Abstract Hematopoiesis is developmentally immature in the newborn compared with the adult. Diminished gene expression of several positive hematopoietic regulators has been observed in activated cord compared with adult peripheral blood mononuclear cells (MNC; Cairo et al. Pediatr Res, 30:362, 1991 and Cairo et al, Pediatr Res, 31:574, 1992). However, altered expression of negative hematopoietic regulators during states of increased demand may also contribute to the pathogenesis of newborn dyshematopoiesis. To test this hypothesis, we measured protein levels of transforming growth factor-beta 1
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27

Chang, M., Y. Suen, SM Lee, et al. "Transforming growth factor-beta 1, macrophage inflammatory protein-1 alpha, and interleukin-8 gene expression is lower in stimulated human neonatal compared with adult mononuclear cells." Blood 84, no. 1 (1994): 118–24. http://dx.doi.org/10.1182/blood.v84.1.118.bloodjournal841118.

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Hematopoiesis is developmentally immature in the newborn compared with the adult. Diminished gene expression of several positive hematopoietic regulators has been observed in activated cord compared with adult peripheral blood mononuclear cells (MNC; Cairo et al. Pediatr Res, 30:362, 1991 and Cairo et al, Pediatr Res, 31:574, 1992). However, altered expression of negative hematopoietic regulators during states of increased demand may also contribute to the pathogenesis of newborn dyshematopoiesis. To test this hypothesis, we measured protein levels of transforming growth factor-beta 1 (TGF-bet
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28

Nakamura, T., I. Ebihara, M. Fukui, et al. "Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice." Journal of the American Society of Nephrology 4, no. 4 (1993): 1064–72. http://dx.doi.org/10.1681/asn.v441064.

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The renal mRNA levels of endothelin (ET)-1 and ET-3 and for ET receptors A and B were measured in the cystic kidneys of cpk/cpk mice at 1, 2, and 3 wk of age. At 1 wk of age, renal ET-1 mRNA was 3.2-fold greater in cystic mice than in controls and continued to increase with the progression of cyst formation to reach 10.4-fold more than controls at 3 wk. ET-3 mRNA levels did not differ between cystic and control mice. Renal ETA and ETB receptor mRNA increased gradually in cystic mice with the progression of their cysts, reaching 4.2- and 6.3-fold increases over controls, respectively, at 3 wk.
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29

Daniel, Dr Yvonne, Stephen Obaro, John Dada, Juliana Olufunke Lawson, and Baba PD Inusa. "Use of HbA2 As a Discriminator for S/Beta Thalassaemia in a Nigerian Setting,." Blood 118, no. 21 (2011): 4206. http://dx.doi.org/10.1182/blood.v118.21.4206.4206.

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Abstract Abstract 4206 An integral part of an EU-UNDP funded pilot sickle cell screening project, was the installation, in Abuja (Federal Capital Territory) Nigeria, June 2010, of a High Performance Liquid Chromatography (HPLC) instrument. Prior to the installation, haemoglobinopathy screening was carried out using only unstained paper electrophoresis. Minor bands were difficult to visualise and the proportions of haemoglobins were not measured. Full blood count (FBC) data was also not routinely available. Therefore awareness of both alpha and beta thalassaemia was low as was the implications
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30

Sun, Y., and W. J. Ball. "Determination of Na(+)-K(+)-ATPase alpha- and beta-isoforms and kinetic properties in mammalian liver." American Journal of Physiology-Cell Physiology 262, no. 6 (1992): C1491—C1499. http://dx.doi.org/10.1152/ajpcell.1992.262.6.c1491.

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While Western blot analysis clearly revealed the presence of the alpha- and beta-subunits of Na(+)-K(+)-ATPase in a variety of rat tissues, beta was not readily detectable in liver. This observation was consistent with a previous report indicating that Na(+)-K(+)-ATPase immunoprecipitated from rat liver gives no clear evidence for the presence of a beta-subunit (Hubert et al. Biochemistry 25: 4156-4163, 1986). However, Western blot analysis of density gradient-purified lamb and rat liver microsomes showed the presence of a protein with an approximate molecular mass of 42 kDa that was immunorea
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31

Lavoie, L., D. Roy, T. Ramlal, et al. "Insulin-induced translocation of Na(+)-K(+)-ATPase subunits to the plasma membrane is muscle fiber type specific." American Journal of Physiology-Cell Physiology 270, no. 5 (1996): C1421—C1429. http://dx.doi.org/10.1152/ajpcell.1996.270.5.c1421.

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We have previously shown that an acute insulin treatment induces redistribution of the alpha 2- and beta 1- isoforms of the Na(+)-K(+)-ATPase from intracellular membranes to plasma membranes detected on subcellular fractionation of mixed muscles and immunoblotting with isoform-specific antibodies (H. S. Hundal et al. J. Biol. Chem. 267: 5040-5043, 1992). In the present study we give both biochemical and morphological evidence that this insulin effect is operative in muscles composed mostly of oxidative (red) fibers but not in muscles composed mostly of glycolytic (white) fibers. The redistribu
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32

Santoro, S. A., J. J. Walsh, W. D. Staatz, and K. J. Baranski. "Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation." Cell Regulation 2, no. 11 (1991): 905–13. http://dx.doi.org/10.1091/mbc.2.11.905.

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Recent studies have revealed that the sequence of amino acids asp-gly-glu-ala represents an essential determinant of the site within the alpha 1(I)-CB3 fragment of collagen recognized by the alpha 2 beta 1 integrin cell surface collagen receptor (Staatz et al., 1991). Studies employing chemical modifications of collagen amino acid side chains confirm both the essential nature of the acidic side chains of aspartic acid and glutamic acid residues and the nonessentiality of lysine epsilon-amino groups in supporting adhesion mediated by the alpha 2 beta 1 integrin. The approach also indicates the
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33

Picken, Christie, Adam R. Clarke, Robert J. Barry, Rory McCarthy, and Mark Selikowitz. "The Theta/Beta Ratio as an Index of Cognitive Processing in Adults With the Combined Type of Attention Deficit Hyperactivity Disorder." Clinical EEG and Neuroscience 51, no. 3 (2019): 167–73. http://dx.doi.org/10.1177/1550059419895142.

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An elevated theta/beta ratio in the EEG has long been observed among individuals with Attention Deficit Hyperactivity Disorder (ADHD). The theta/beta ratio was previously hypothesised to be an index of arousal, but a number of studies failed to find any association between the ratio and indices of arousal, instead proposing that the theta/beta ratio may actually be indicative of cognitive processing. This hypothesis was tested by Clarke et al using a sample of healthy adults, with results indicating that the theta/beta ratio correlated with a marker of cognitive processing (P300 latency in an
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34

Bhutada, A., and F. Ismail-Beigi. "Serum and growth factor induction of Na(+)-K(+)-ATPase subunit mRNAs in Clone 9 cells: role of protein kinase C." American Journal of Physiology-Cell Physiology 261, no. 4 (1991): C699—C707. http://dx.doi.org/10.1152/ajpcell.1991.261.4.c699.

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In a previous study, we found that addition of serum to confluent Clone 9 cells, a nontransformed rat liver cell line, increased the abundance of mRNA alpha 1 and mRNA beta 1 at 3 h by 2- and 2.7-fold, respectively [Bhutada et al. Am. J. Physiol. 258 (Cell Physiol. 27): C1044-C1050, 1990]. We now report that exposure of these cells to 160 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 6 h increases mRNA alpha 1 and mRNA beta 1 by 1.7 +/- 0.2- and 2.1 +/- 0.3-fold, respectively. Incubation in the presence of 160 nM TPA for 24 h reduced high-affinity phorbol dibutyrate-binding sites [dissocia
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35

Passam, Freda H., Lin Lin, Mingdong Huang, Jonathan M. Gibbins, Bruce Furie, and Barbara C. Furie. "Role of Thiol Isomerase ERp5 in Thrombus Formation." Blood 118, no. 21 (2011): 370. http://dx.doi.org/10.1182/blood.v118.21.370.370.

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Abstract Abstract 370 Protein disulfide isomerase is required for thrombus formation in various in vivo models of thrombosis. Another member of the thiol isomerase family, endoplasmic reticulum protein 5 (ERp5), is released from activated platelets and co-immunoprecipitates with beta 3 integrin (Jordan et al, 2005). We further investigated the association of ERp5 with the platelet fibrinogen receptor alpha IIb beta 3 and the significance of ERp5 release in thrombus formation in vivo. Recombinant purified ERp5 was labeled with Alexa 488 and used in direct binding assays to CHO cells expressing
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36

Kirsch, G. E., A. Yatani, J. Codina, L. Birnbaumer, and A. M. Brown. "Alpha-subunit of Gk activates atrial K+ channels of chick, rat, and guinea pig." American Journal of Physiology-Heart and Circulatory Physiology 254, no. 6 (1988): H1200—H1205. http://dx.doi.org/10.1152/ajpheart.1988.254.6.h1200.

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A specific guanine nucleotide-binding protein, Gk, is the link by which muscarinic receptors activate atrial potassium channels (Science Wash. DC 235: 207-211, 1987). In adult guinea pigs, the alpha-subunit at picomolar concentrations mediates the holo-G protein effect (Science Wash. DC 236: 442-445, 1987), but in chick embryo it has been reported that the beta gamma-dimer at nanomolar concentrations rather than the alpha-subunit is the effective mediator (Nature Lond. 325: 321-326, 1987). This difference might have a phylogenetic or ontogenetic basis, and the present experiments tested these
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37

Hood, J. S., B. D. Nossaman, I. N. Ibrahim, T. J. McMahon, C. R. Babycos, and P. J. Kadowitz. "Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat." Journal of Applied Physiology 72, no. 6 (1992): 2305–10. http://dx.doi.org/10.1152/jappl.1992.72.6.2305.

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The influence of daltroban (BM13.505; SK&F 96148), a thromboxane (Tx) A2-receptor-blocking agent, on responses to the TxA2 mimics U-46619 and U-44069 was investigated in the pulmonary vascular bed of the intact-chest cat under constant-flow conditions. Daltroban (5 mg/kg iv) had no significant effect on mean baseline vascular pressures but significantly decreased responses to the TxA2 mimics without altering responses to prostaglandin (PG) F2 alpha or PGD2 or the PGD2 metabolite 9 alpha, 11 beta-PGF2. Dose-response curves for U-46619 and U-44069 were shifted to the right in a parallel mann
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38

Woo, Andrew J., Jonghwan Kim, Jian Xu, Hui Huang, and Alan Cantor. "Role of the Krüppel-Type Zinc Finger Transcription Factor ZBP-89 In Human Globin Gene Regulation and Erythroid Development." Blood 116, no. 21 (2010): 2067. http://dx.doi.org/10.1182/blood.v116.21.2067.2067.

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Abstract Abstract 2067 The molecular mechanisms underlying developmental globin gene regulation remain incompletely understood. Prior studies have identified key cis-regulatory elements within the beta globin locus that contain core regions of closely spaced functional binding sites for GATA, NF-E2p45/maf and GT/GC box binding transcription factors. We recently identified the GT/GC-box binding transcription factor ZBP-89 as a novel GATA-1 interacting partner, and showed that it is involved in erythroid development in mice (Woo et al. 2008. Mol. Cell Bio. 28:2675-2689). Brand et al. independent
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39

Querfeld, Christiane, Xiwei Wu, Hanjun Qin, Chingyu Su, Zhen Han, and Steven T. Rosen. "Paired Single Cell RNA and TCR Sequencing Analysis Following PD-L1 Blockade in Cutaneous T-Cell Lymphoma." Blood 136, Supplement 1 (2020): 21–22. http://dx.doi.org/10.1182/blood-2020-139992.

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Introduction: T cell exhaustion is a hallmark of CTCL and alterations in mRNA profiles correlate with immune checkpoint expression, with potential clinical relevance (Querfeld et al. 2018). There is no immunophenotypic marker that can distinguish malignant CD4+ T cells from benign CD4+ T cells in the infiltrate and intratumoral heterogeneity poses a major challenge to treatments and long-term remissions. The microenvironment in CTCL harbors multiple immune cells that may contribute to the development of resistance to drug treatments; however, the genomic and molecular determinants of response
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40

Hill, S. L., K. Krishnan, and J. R. Ferraro. "The Characterization Of Organic Charge Transfer Superconductors By Microreflectance Spectroscopy." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 2 (1990): 272–73. http://dx.doi.org/10.1017/s042482010013496x.

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Certain classes of organic charge-transfer salts demonstrate superconducting behavior at liquid helium temperatures. Single crystal x-ray diffraction and infrared microreflectance analysis have been performed on several conducting systems to associate the nature of the crystalline structure with the electrical conductivity. The infrared spectrum for a single crystal salt exhibits absorptions which correlate with superconducting behavior.Discussion Williams and coworkers have performed x-ray Crystallography experiments to demonstrate the presence of an anion cavity between radical cation stacks
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41

Wileman, T., LP Kane, J. Young, GR Carson, and C. Terhorst. "Associations between subunit ectodomains promote T cell antigen receptor assembly and protect against degradation in the ER." Journal of Cell Biology 122, no. 1 (1993): 67–78. http://dx.doi.org/10.1083/jcb.122.1.67.

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The T cell antigen receptor (TCR) is an oligomeric protein complex made from at least six different integral membrane proteins (alpha beta gamma delta epsilon and zeta). The TCR is assembled in the ER of T cells, and correct assembly is required for transport to the cell surface. Single subunits and partial receptor complexes are retained in the ER where TCR alpha, beta, and CD3 delta chains are degraded selectively. The information required for the ER degradation of the TCR beta chain is confined to the membrane anchor of the protein (Wileman et al., 1990c; Bonifacino et al., 1990b). In this
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42

Nakamura, T., D. M. Donovan, K. Hamada, et al. "Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes." Molecular and Cellular Biology 10, no. 7 (1990): 3700–3708. http://dx.doi.org/10.1128/mcb.10.7.3700.

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We have shown by site-directed mutagenesis that the sequence between positions -69 and -40 of the mouse alpha A-crystallin gene is crucial for tissue-specific gene expression in a transfected mouse lens epithelial cell line transformed with the early region of simian virus 40. Gel retardation experiments with synthetic oligodeoxynucleotides revealed a mouse lens nuclear protein which bound specifically to the palindromic sequence 5'-GGGAAATCCC-3' at positions -66 to -57 in the alpha A-crystallin promoter. By screening a bacteriophage lambda gt11 expression library of the transformed lens cells
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43

Nakamura, T., D. M. Donovan, K. Hamada, et al. "Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes." Molecular and Cellular Biology 10, no. 7 (1990): 3700–3708. http://dx.doi.org/10.1128/mcb.10.7.3700-3708.1990.

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We have shown by site-directed mutagenesis that the sequence between positions -69 and -40 of the mouse alpha A-crystallin gene is crucial for tissue-specific gene expression in a transfected mouse lens epithelial cell line transformed with the early region of simian virus 40. Gel retardation experiments with synthetic oligodeoxynucleotides revealed a mouse lens nuclear protein which bound specifically to the palindromic sequence 5'-GGGAAATCCC-3' at positions -66 to -57 in the alpha A-crystallin promoter. By screening a bacteriophage lambda gt11 expression library of the transformed lens cells
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44

Saini, Neeraj, Chia-Chi Chang, Paolo Strati, et al. "Gut Bacterial Diversity Associates with Efficacy of Anti-CD19 CAR T-Cell Therapy in Patients with Large B-Cell Lymphoma." Blood 136, Supplement 1 (2020): 34–35. http://dx.doi.org/10.1182/blood-2020-136756.

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Introduction: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has improved survival outcomes in patients with relapsed/refractory (r/r) large B-cell lymphoma (LBCL). However, many patients experience systemic toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) and about 60% relapse. Recent studies indicate that the gut microbiome can modulate tumor response and also influence toxicities associated with immune checkpoint inhibitor therapy. However, the influence of gut microbiome has not been well-studied in patients rec
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45

Ojakian, G. K., and R. Schwimmer. "Regulation of epithelial cell surface polarity reversal by beta 1 integrins." Journal of Cell Science 107, no. 3 (1994): 561–76. http://dx.doi.org/10.1242/jcs.107.3.561.

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The role of extracellular matrix in the regulation of epithelial cell surface polarity development was studied using MDCK cells. Previous work has demonstrated that MDCK cells cultured in suspension form epithelial cysts having polarized cell surface distributions of several membrane proteins. When MDCK suspension cysts are incubated within collagen gel, a dynamic epithelial membrane remodeling occurs that is accompanied by the reversal of cell surface polarity (Wang et al., 1990b, J. Cell Sci. 95, 153–165), suggesting that extracellular matrix is important in the modulation of epithelial pola
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46

Neer, E. J., L. G. Wolf, and D. M. Gill. "The stimulatory guanine-nucleotide regulatory unit of adenylate cyclase from bovine cerebral cortex ADP-ribosylation and purification." Biochemical Journal 241, no. 2 (1987): 325–36. http://dx.doi.org/10.1042/bj2410325.

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Hormonal stimulation of adenylate cyclase from bovine cerebral cortex is mediated by a guanine-nucleotide regulatory protein (Gs). This protein contains at least three polypeptides: a guanine nucleotide-binding alpha s component and a beta X gamma component, which modulates the function of alpha s. The alpha s component from many tissues can be ADP-ribosylated with cholera toxin, but has been unusually difficult to modify in brain. We have improved incorporation of ADP-ribose by including isonicotinic acid hydrazide to inhibit the potent NAD glycohydrolase activity of brain. ADP-ribosylation i
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47

Makropoulos, Dorie, Ram Achuthanandam, Patricia Rafferty, et al. "Activity of CNTO 530 in a Murine Model of Sickle Cell Anemia." Blood 114, no. 22 (2009): 4606. http://dx.doi.org/10.1182/blood.v114.22.4606.4606.

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Abstract Abstract 4606 CNTO 530 is an erythropoietin receptor agonist MIMETIBODYTM construct. CNTO 530 has been shown to be active in a number of rodent models of acquired anemia (e.g. renal insufficiency and chemotherapy induced anemia) and in a model of beta-thalassemia. Here we report on the activity of CNTO 530 in murine globin KO-human HbS transgenic (sickle cell) mice. Berkeley mice, as originally described by Pászty et al (Pászty et al. Science 1997), are knocked out for murine alpha and beta globin and are transgenic for human alpha, beta (sickle) and gamma globin genes. Thus, these
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48

Knight, Andrea, Stephen Mackinnon та Mark W. Lowdell. "CMV-Reactive γ/δ T Cells Are Equivalent to Their α/β Counterparts In the Lysis of CMV-Infected Targets – Potential for Post Transplant Adoptive Immunotherapy." Blood 116, № 21 (2010): 1277. http://dx.doi.org/10.1182/blood.v116.21.1277.1277.

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Abstract Abstract 1277 Reactivation of cytomegalovirus (CMV) post allogeneic stem cell transplantation (SCT) can be prevented and treated by adoptive immunotherapy with donor-derived alpha/beta CMV-reactive T cells (CMV-T). We have reported that VD1+ gamma/delta T cells arising post allogeneic SCT are also CMV-reactive and that these cells can be identified in and isolated from CMV-seronegative donors (Knight et al 2010). The relative ability of VD1 gamma/delta cells to lyse CMV-infected targets compared to CMV-reactive alpha/beta T cells has not been determined. Here we have isolated gamma/de
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49

Mudhar, H. S., R. A. Pollock, C. Wang, C. D. Stiles, and W. D. Richardson. "PDGF and its receptors in the developing rodent retina and optic nerve." Development 118, no. 2 (1993): 539–52. http://dx.doi.org/10.1242/dev.118.2.539.

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We have used in situ hybridization to visualize cells in the developing rat retina and optic nerve that express mRNAs encoding the A and B chains of platelet-derived growth factor (PDGF-A and PDGF-B), and the alpha and beta subunits of the PDGF receptor (PDGF-alpha R and PDGF-beta R). We have also visualized PDGF-A protein in these tissues by immunohistochemistry. In the retina, PDGF-A mRNA is present in pigment epithelial cells, ganglion neurons and a subset of amacrine neurons. PDGF-A transcripts accumulate in ganglion neurons during target innervation and in amacrine neurons around the time
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50

Weinberg, J. Brice, Danielle M. Brander, Dale J. Christensen, and Daphne R. Friedman. "Post‐translational regulation could be determine functional differences between SET alpha and beta isoform – Response to Cristóbal et al." British Journal of Haematology 186, no. 4 (2019): 637. http://dx.doi.org/10.1111/bjh.15934.

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