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Journal articles on the topic 'Divine twins'
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1
Blickstein, Isaac. "The conjoined twins of Löwen." Twin Research 3, no. 4 (2000): 185–88. http://dx.doi.org/10.1375/twin.3.4.185.
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AbstractThis paper discusses an unusual etching of unlike-sex conjoined twins of the syncephalus type dated 1547. The authenticity of the case is discussed in terms of the biological plausibility of such twins and in the light of mediaeval understanding of the twinning process. Unlike-sex syncephalic twins may occur as a result of dispermic fertilisation, or be an erroneous depiction of an asymmetrical anomaly of the external genitalia of a like-sex pair, mimicking the genitals of the other sex. On the other hand, the Löwen etching conforms with mediaeval beliefs that conjoined twins are divine punishment and therefore were used for ecclesiastical and perhaps commercial purposes. The historical context of the drawing, in which the relation between religion, media, and medicine satisfied the eagerness of the public for curios of Nature, is no longer valid. Thus the Löwen etching opens a window to the past from which modern medicine can be appreciated. Twin Research (2000) 3, 185–188.
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Lloyd, Naomi. "THE UNIVERSAL DIVINE PRINCIPLE, THE SPIRITUAL ANDROGYNE, AND THE NEW AGE IN SARAH GRAND'S THE HEAVENLY TWINS." Victorian Literature and Culture 37, no. 1 (2009): 177–96. http://dx.doi.org/10.1017/s1060150309090111.
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In February 1893 the feminist journal Shafts published two articles by Mrs. A. Phillips the second of which provided an esoteric reading of the crucifixion in which Phillips, making recourse to Sanskrit, argued that Christ's death on the cross symbolized the “perfect marriage union of the male and female” (qtd. in Dixon, Divine Feminine 163). Feminist theosophists such as Phillips believed Christianity's neglect of the Divine Feminine to have resulted in a masculinist ordering of religious authority and in the concomitant subordination of women. The editor of Shafts, Margaret Shurmer Sibthorpe, agreed; she added a note to Phillips's second article urging her readers to work towards the formulation of a gospel that would facilitate women's emancipation. In the same issue of Shafts, Sarah Grand's The Heavenly Twins was reviewed. The reviewer cited at length a passage from the novel's Proem characterizing the divine as the union of the male and female principles and concluded with a discussion of the “heavenly twins” of the novel's title. The Shafts reviewer, however, did not explore the significance of religious allusions in The Heavenly Twins, nor did she examine the relation between the dual-sexed divine of the Proem and the story of the heavenly twins, Angelica and Diavolo Hamilton-Wells. Subsequent Grand scholars have not, for the most part, taken up these questions. The possibility that the novel might constitute an attempt to reconfigure dominant discourses of religion and gender, of the kind Sibthorpe had called for and Phillips undertaken, is largely unconsidered. The New Woman as a “modern maiden” is instead assumed to emerge from a predominantly secular cultural context.
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Alexander Nikolaev. "Avestan Haēcat̰.aspa-, Rigveda 4.43, and the Myth of the Divine Twins." Journal of the American Oriental Society 132, no. 4 (2012): 567. http://dx.doi.org/10.7817/jameroriesoci.132.4.0567.
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Martínez Zepeda, Baruch. "A NOTE ON OVID, HEROIDES 6.117–18." Classical Quarterly 69, no. 2 (2019): 764–68. http://dx.doi.org/10.1017/s000983881900079x.
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At Her. 6.113–18 Hypsipyle lays out for Jason the advantages to be gained by marrying her: the prestige of her noble and even divine family, and the fertile island of Lemnos, which will come as her dowry. She then adds the fact that she is pregnant with twins (6.119–22); this thought introduces a new section, which extends until line 130.
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Blakely, Sandra. "Starry Twins and Mystery Rites: From Samothrace to Mithras." Acta Antiqua Academiae Scientiarum Hungaricae 58, no. 1-4 (2018): 427–63. http://dx.doi.org/10.1556/068.2018.58.1-4.26.
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Summary Iconographic analogies between the Mithraic torchbearers, Cautes and Cautopates, and the Greek Dioscuri encourage a comparative analysis of these figures in context. Previous studies have emphasized the potential for the divine twins to be the origins of the torchbearers: a closer examination of the Dioscuri as they functioned within another mystery cult, the rites of the Great Gods of Samothrace, offers light on both the phenomenology of initiation and the cultural context common to both the Greek and the Roman rituals. Among the numerous visual and conceptual parallels, the strongest commonality between the two sets of youths is a cultural appetite for astral mysticism, which connects the late Republican Roman voices on Samothrace and the later world of the Mithraic caves. The two mysteries served, however, profoundly different functions with respect to Roman identity – a dynamic which the parallel presence of twinned, framing shining lights reveals.
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Sanko, Siarhei. "Reflexes of Ancient Ideas about Divine Twins in the Images of Saints George and Nicholas in Belarusian Folklore." Folklore: Electronic Journal of Folklore 72 (August 2018): 15–40. http://dx.doi.org/10.7592/fejf2018.72.sanko.
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Kaprio, J., R. J. Rose, S. Sarna, et al. "Design and Sampling Considerations, Response Rates, and Representativeness in a Finnish Twin Family Study." Acta geneticae medicae et gemellologiae: twin research 36, no. 1 (1987): 79–93. http://dx.doi.org/10.1017/s000156600000461x.
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AbstractKinships composed of twin parents, their spouses and children, offer a robust and flexible sampling design for research in genetic epidemiology. Families-of-twins designs circumvent some of the sampling problems that arise when independent data sets are combined, and these designs provide unique evaluations of maternal influences, assortative mating and X-linkage. Unfortunately, empirical studies of families of twin parents have been limited by relatively small samples and by the self-selection biases intrinsic in ascertainment of families from volunteer twin registries.A large and representative cohort of monozygotic and dizygotic twin parents, drawn from a population-based twin registry, provides the optimal sampling frame for twin-family research. This paper reviews the sampling considerations underlying the initial family study based on the Finnish Twin Cohort and evaluates the representativeness of the sampled twins. Spouses and adult children (over 18 years) of 236 pairs of twins, about equally divided by gender and zygosity, were evaluated by a postal questionnaire. Individual response rates exceeded 86% and in 464 of the 472 nuclear families (98.3% ), at last one member of the twin's family completed the questionnaire. The sampled twins, selected for fecundity to maximize statistical power of the obtained data, were broadly representative of non-selected twins drawn from the Cohort, with whom they were matched on age, gender, and zygosity. Such results suggest that the Finnish Cohort has excellent potential for extended twin-family research designs.
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Kulikov, Leonid. "The First Woman Yamī, Her Origin and Her Status in Indo-Iranian Mythology: Demigoddess or Half-human? (Evidence from R̥gveda 10.10, Iranian Parallels and Greek Relatives)." Studia Ceranea 8 (December 30, 2018): 43–75. http://dx.doi.org/10.18778/2084-140x.08.03.
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This paper focuses on the mythology of Yamī and her twin-brother Yama (the first humans according to Indo-Iranian mythology), their non-human origin and some aspects of Yamī’s behaviour which presumably betray a number of features of a female half-deity. The relationships between Yamī and Yama are the central topic of the dialogue hymn Rgveda 10.10, where Yamī attempts to seduce her twin to incest in order to produce offspring and thus continue the human race. This offer is refused by Yama, who refers to the inappropriateness of incest. Although Yamī and Yama are humans according to the Vedic tradition, their origin from two half-deities – a Gandharva father and an Apsara mother – remains inexplicable: how could a couple of non-human beings (half-deities or demons) give birth to humans? Obviously, the mythological status of the twins should be reconsidered. I argue that at least one of them, Yamī, retains immortality and some other features of the non-human (semi-divine) nature. On the basis of the analysis of the Yama and Yamī hymn and some related Vedic texts, I argue that this assumption may account for certain peculiarities of Yamī’s behaviour – particularly her hypersexuality (which can be qualified as demonic type of behaviour), as opposed to the much more constrained, human type of conduct displayed by Yama. Given the notoriously lustful character of the Gandharvas, an origin from this semi-divine creature may account for Yamī’s hypersexuality. Although the word gandharvá- does not have Indo-European etymology, we can find possible Indo-European parallels. In particular, the Gandharvas are comparable with the Centaurs, which cannot be etymologically related but possibly originate in the same non-Indo-European source. There are some reasons to assume that both words are borrowed from the Kassite language and mythology, which, in turn, may have been related to the language and culture of the Proto-North-Caucasians. Although we do not find exact equivalents of Yamī outside of the Indo-Iranian pantheon, indirect parallels can be found in other Indo-European traditions. The Apsaras (water nymphs) can be compared to a variety of water deities (nymphs) in Greek mythology, such as the Naiads, or to the Slavic rusalki.
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Andújar, Rosa. "UNCLES EX MACHINA: FAMILIAL EPIPHANY IN EURIPIDES’ ELECTRA." Ramus 45, no. 2 (2016): 165–91. http://dx.doi.org/10.1017/rmu.2016.9.
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At the close of Euripides’ Electra, the Dioscuri suddenly appear ‘on high’ to their distraught niece and nephew, who have just killed their mother, the divine twins’ mortal sister. This is in fact the second longest extant deus ex machina (after the final scene in Hippolytus), and the only scene in which a tragedian attempts to resolve directly the aftermath of the matricide. In this article, I argue that Castor's and Polydeuces’ sudden apparition to Orestes and Electra constitutes a specialised point of intersection between the mortal and immortal realms in Greek tragedy: familial epiphany, an appearance by a god who has an especially intimate relationship with those on stage. Euripides’ focus on the familial divine as a category accentuates various contradictions inherent to both ancient Greek theology and dramaturgy. The Dioscuri are a living paradox, ambiguously traversing the space between dead heroes and gods, managing at the same time to occupy both. They oscillate uniquely between the mortal and immortal worlds, as different sources assign different fathers to each brother, and others speak of each one possessing divinity on alternate days. As I propose, the epiphany of these ambiguous brothers crystallises the problem of the gods’ physical presence in drama. Tragedy is the arena in which gods burst suddenly into the mortal realm, decisively and irrevocably altering human action. The physical divine thus tends to be both marginal and directorial, tasked with reining in the plot or directing its future course. The appearance of the familial divine, on the other hand, can in fact obscure the resolution and future direction of a play, undermining the authority of the tragic gods. In the specific case of Electra, I contend that the involvement of the Dioscuri, who are Electra's and Orestes’ maternal uncles, produces a sense of claustrophobia at the close of the play, which simultaneously denies the resolution that is expected from a deus ex machina while also revealing the pessimistic nature of what is typically considered a reassuringly ‘domestic’ and character driven drama.
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Siribaddana, Sisira Hemananda, Waduthanthrige Danushki Siriwardane, Suwin Nilanga Hewage, Athukoralage Don Manjula Deshapriya Athukorale, Athula Sumathipala, and Matthew Hotopf. "Update From Sri Lankan Twin Registry: Establishment of a Population-Based Twin Register and Ongoing Project on Common Mental Disorders, Alcohol Abuse and Suicidal Ideations." Twin Research and Human Genetics 9, no. 6 (2006): 868–74. http://dx.doi.org/10.1375/twin.9.6.868.
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AbstractThe Sri Lankan Twin Registry began as a volunteer register in 1997. Previously, we have shown door-to-door surveys as the best option to build a population-based twin register of older, adult twins. Our aim was to build a population-based twin register in the Colombo district and use it for twin studies on common mental disorders. We aimed to identify a random sample of 4000 twins ascertained through the twin census. The Colombo district is divided into 13 divisional secretariat divisions (DSDs) and each division is further divided into Grama Niladari divisions administratively. Grama niladaris (GNs) are civil servants and visit each household in order to update the electoral register. GNs were used to do a census of twins while they updated the electoral register. The correlation between population density and twin rate among DSDs was .81, and between twin rate and the percentage of returned forms (from each DSD) was .74. We received 9648 forms notifying about twins and multiples. After removing the duplicates and information about twins who live in other districts, there were 17,406 multiples remaining. After incorporating twins and multiples from various other feasibility studies we now have 19,040 multiples with 8.46 twins per 1000 people in the Colombo district.
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Kato, Noriko, and Tomohiro Matsuda. "The Relationship Between Birthweight Discordance and Perinatal Mortality of One of the Twins in a Twin Pair." Twin Research and Human Genetics 9, no. 2 (2006): 292–97. http://dx.doi.org/10.1375/twin.9.2.292.
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AbstractThis study aimed to evaluate the prevalence of birth-weight discordance among twins, to determine the risk cut-off point for birthweight discordance, and to clarify whether perinatal deaths are aggravated by birthweight discordance or by low birthweight itself. A population-based analysis of all twins born between 1995 and 1999 in Japan was conducted using data collected from national birth, death and stillbirth certificates. Birthweight discordance was determined as: higher birthweight minus lower birthweight divided by higher birthweight multiplied by 100. Among twins with a birthweight discordance of more than 15%, the fetal and perinatal mortality rate was higher than that of twins with a discordance of less than 15%. Ninety per cent of the relative cumulative frequency of twin live-births were within 25% of the birthweight discordance. Logistic regression analysis showed that the stillbirth of at least one of the twins is associated with the birthweight of the larger twin and birthweight discordance. It also showed that the stillbirth of both twins in the twin pair is associated with the birth-weight of larger twins and the gestational weeks. It was clarified that birthweight discordance was associated with the stillbirth of only one twin in the twin pair, and the stillbirth of both twins in the twin pair was associated with low birthweight itself.
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Jaszczyński, Maciej. "Indo-European Roots of the Helen of Troy." Studia Ceranea 8 (December 30, 2018): 11–22. http://dx.doi.org/10.18778/2084-140x.08.01.
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As a part of the series on female deities and demons in the Indo-European culture, the article begins by establishing Helen’s divine character in the Greek tradition and religion. The first area where the Indo-European character of Helen is displayed concerns the etymology of her name, which has been the subject of discussion and controversy throughout several decades. The most prominent theories are presented, including the concept of Pokorny and West to explain her name as ‘Lady of Light’ from the Proto-Indo-European root *swel- or *swelh1-, the idea of Skutsch to connect Helen with Vedic Saṛanyū, the etymology by Clader relying on the local Greek ritual practices and finally the new etymology provided by Pinault explaining the name as ‘having a year like a thread’ from Proto-Indo-European *suh1-l̥-h1eno. The second part of the article deals with the cultural, literary and religious attributes of Helen which connect her with the Indo-European world, especially with the Vedic tradition. The most interesting aspects include the issue of Helen’s parenthood and her birth, her relationship with her brothers – the Dioskouroi – the prototypical Indo-European Divine Twins, as well as similarities with Vedic goddesses Uṣās – Dawn and Sūryā́ – the Sun Princess. The final part of the article establishes Helen as the Greek representation of the Indo-European myth of an abducted wife. Relying heavily on the analysis of Jamison, it draws on the similarities between the passages in the book III of the Mahābhārata and the book III of the Iliad, which from the comparative perspective explains well the inclusion of this scene in the Homeric epic and Helen’s role in it as well as sheds more light on the Indo-European practices regarding marriage. Lastly, the article mentions a connection between Helen and Vedic Saṛanyū by the story of eidolon – a phantom, which both characters created at certains points in some literary traditions.
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Zhang, Min, Xiaomin Hang, Jing Tan, and Hong Yang. "The Host Genotype and Environment Affect Strain Types of Bifidobacterium longum subsp. longum Inhabiting the Intestinal Tracts of Twins." Applied and Environmental Microbiology 81, no. 14 (2015): 4774–81. http://dx.doi.org/10.1128/aem.00249-15.
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ABSTRACTTo investigate the influences of host genotype and environment onBifidobacterium longumsubsp.longuminhabiting human intestines at the strain level, six pairs of twins, divided into two groups (children and adults), were recruited. Each group consisted of two monozygotic (MZ) twin pairs and one dizygotic (DZ) twin pair. Child twins had been living together from birth, while adult twins had been living separately for 5 to 10 years. A total of 345B. longumsubsp.longumisolates obtained from 60 fecal samples from these twins were analyzed by multilocus sequence typing (MLST), and 35 sequence types (STs) were finally acquired. Comparison of strains within and between the twin pairs showed that no strains with identical STs were observed between unrelated individuals or within adult DZ twin pairs. Eight STs were found to be monophyletic, existing within MZ twins and child DZ twins. The similarity of strain types within child cotwins was significantly higher than that within adult cotwins, which indicated that environment was one of the important determinants inB. longumsubsp.longumstrain types inhabiting human intestines. However, although these differences between MZ and DZ twins were observed, it is still difficult to reach an exact conclusion about the impact of host genotype. This is mainly because of the limited number of subjects tested in the present study and the lack of strain types tracing in the same twin pairs from birth until adulthood.
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Chang, Yao-lung, Shuenn-dyh Chang, An-shine Chao, Chao-nin Wang, Tzu-hao Wang, and Po-jen Cheng. "The Relationships of Umbilical Venous Volume Flow, Birthweight and Placental Share in Monochorionic Twin Pregnancies With and Without Selective Intrauterine Growth Restriction." Twin Research and Human Genetics 14, no. 2 (2011): 192–97. http://dx.doi.org/10.1375/twin.14.2.192.
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This study was conducted to investigate the relationship among umbilical venous volume flow, birthweight and placental share in monochorionic twins with or without selective growth restriction. Having excluded cases complicated with twin-to-twin transfusion syndrome and one co-twin suffering intrauterine fetal death, a total of 51 monochorionic twin pregnancies were divided into two groups as with (group 1) and without (group 2) selective intrauterine growth restriction. Umbilical venous volume flow was calculated by multiplying the umbilical vein cross-sectional area by half of the maximal velocity around mid-trimester. The placentas were cut along the vascular equator into two individual placental masses. The discordance of birthweight was calculated as [(birthweight of larger twin—birthweight of smaller twin)/birthweight of larger twin 100%]. The discordances of umbilical venous volume flow and placental share were calculated in a similar fashion. The median umbilical venous volume flow discordances (68.4% and 15.3% in groups 1 and 2 monochorionic twins, respectively) were similar and correlated well with the placental share discordances (66.6% and 18.5% in groups 1 and 2 monochorionic twins, respectively) but not with the birthweight discordance (28.6% and 6.4% in groups 1 and 2 monochorionic twins, respectively) in both groups. We concluded that the umbilical venous volume flow discordance reflects the placental share discordance rather than the birthweight discordance in monochorionic twin pregnancies.
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Hur, Yoon-Mi. "Common Genetic Influences on Age at Pubertal Voice Change and BMI in Male Twins." Twin Research and Human Genetics 23, no. 4 (2020): 235–40. http://dx.doi.org/10.1017/thg.2020.65.
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AbstractThe present study aimed to explore secular trends in age at voice change (AVC), estimate heritability of AVC and investigate to what extent common genes influence the association between AVC and body mass index (BMI) in South Korean males. The sample of 955 male twins consisted of 241 pairs and 118 co-twin missing monozygotic (MZ) twins, 82 pairs and 50 co-twin missing dizygotic (DZ) twins and 141 male members of opposite-sex DZ twins who participated in telephone surveys in the South Korean Twin Registry. AVC was asked of twins during the surveys. The mean (SD) age of the sample was 18.92 (2.42) years (range: 16.00–29.25 years). The birth years of the twins were divided into two groups (1988–1993, 1994–2001). Kaplan–Meyer survival analyses were conducted to compute the mean age of AVC in the total sample as well as to test mean differences between the two birth cohorts. Maximum likelihood twin correlations and univariate and bivariate model-fitting analyses were performed. The mean AVC in the total sample was 14.19 (95% CI [14.09, 14.29]) years. The mean AVC significantly declined from 14.38 to 14.02 years from 1988 to 2001, confirming downward trends in AVC in recent years. Heritability for AVC was .59 (95% CI [.50, .67]), which was within the range reported in most Western twin studies. Although the phenotypic correlation between AVC and BMI was modest (r = −.14; 95% CI [−.07, −.21]), it was entirely mediated by common genes, similar to what has been found in females in prior twin studies. In conclusion, the present twin study underscores the importance of genetic influences on pubertal timing and its association with BMI in South Korean males.
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Cochrane, Andrew D., Samuel Menahem, and Roger B. B. Mee. "Divided left atrium with absence of the interatrial septum in monozygotic twins." Cardiology in the Young 3, no. 1 (1993): 51–54. http://dx.doi.org/10.1017/s1047951100010623.
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AbstractDivision of the left atrium is a rare congenital lesion, but one which is amenable to complete surgical correction. We describe twin brothers, demonstrated to be monozygotic, who presented in infancy with cardiac failure, pulmonary congestion and mild cyanosis. Both were found to have systemic and pulmonary venous return to a common atrial chamber, separated from the left atrial appendage and the vestibule supporting the mitral valve by a typical muscular diaphragm with a single small orifice. In one twin, there was also persistence of the left superior caval vein, while, in the other twin, a remnant of the primary atrial septum was present. Excision of the diaphragm and neoseptation of the atrial chambers was performed in both infants. At 10 years after surgery, there was normal growth and development in both twins, with no evidence of recurrent obstruction.
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Konno, Hiroko, Takeshi Murakoshi, Kiyonori Miura, and Hideaki Masuzaki. "The Incidence of Dichorionic Diamniotic Twin Pregnancy After Single Blastocyst Embryo Transfer and Zygosity: 8 Years of Single-Center Experience." Twin Research and Human Genetics 23, no. 1 (2020): 51–54. http://dx.doi.org/10.1017/thg.2020.5.
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AbstractDichorionic diamniotic (DCDA) twin pregnancies after single blastocyst embryo transfer have been reported recently, although a blastocyst ovum is generally believed to divide into monochorionic twin pregnancy. We investigated the incidence of DCDA twin pregnancy after single blastocyst embryo transfer and their zygosity. This prospective cohort study included 655 consecutive twin pregnancies that were managed from 2006 to 2014 at our institution. Chorionicity and amnionicity were determined using first-trimester ultrasonography and/or placental pathology. Zygosity was analyzed if the cases were DCDA twins after single blastocyst embryo transfer. Among 655 twin pregnancies, there were 348 DCDA cases, 295 monochorionic diamniotic (MCDA) cases and 12 monochorionic monoamniotic cases. Single blastocyst embryo transfer was performed in 43 cases. Six out of the 43 (14%) cases involved DCDA twin pregnancies and the other 37 cases involved MCDA twin pregnancies. Three DCDA twins born after single blastocyst embryo transfer, wherein frozen embryo transfer (FET) was performed in the natural cycle, were dizygotic, and the other three cases, wherein FET with hormone replacement therapy was performed, were monozygotic. DCDA twin pregnancy occurred in 14% (7% for monozygotic and 7% for dizygotic) of twin pregnancies after single blastocyst embryo transfer cases.
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Darvin, Alexey Leonidovich. "Origin of Spartan kings from Heracles." RUDN Journal of World History 10, no. 3 (2018): 237–49. http://dx.doi.org/10.22363/2312-8127-2018-10-3-237-249.
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The descent of Spartan kings from Heracles is considered to be the secondary myth interpretation about the “Return of the Heracledae”. It was associated with Dorian conquest of the Peloponnese in the ancient tradition (Tyrtaeus, Pindar, Herodotus, Isocrates, Ephor). The myth of the “Return of the Heracledae” is known to be one of the genealogical fiction what was invented in Argos and developed further in Sparta. There was a powerful argument for inheritance the rights of the royal title and performing the functions of the high priest in the community if the person was known as the descendant of Heracles belonging to the royal dynasties (Agiades and Euripontides). Apart from that, the power of Spartan kings outside Sparta could be justified if they were related to Heracles. In addition, this belonging to the descendants of Heraclides was above everything. It was one of the most important propaganda arguments to substantiate the legitimacy of the possession of conquered lands in Laconia and Messenia and provide “pro-Achaean” policy by the authorities of Sparta. However, the image of Heracles and his cult did not have the essential meaning in the religious life of the Spartan polis. The heavenly patrons of the kings were “divine twins” - the Dioscuri (Tindaridae). To conclude, it seems to be very controversial that the philosophical and ethical image of Heracles (as the main cynic hero) had a great influence on the representatives of the royal diarchy of the late classical and hellenistic periods.
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A., Gigi, Rachel Alexander, and Radhamani K. "Effects of twin pregnancy chorionic properties on fetal outcomes: a comparative study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 9 (2020): 3802. http://dx.doi.org/10.18203/2320-1770.ijrcog20203860.
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Background: Twins carry significant risks to both mothers and babies. The purpose of this study was to evaluate chorionicity and its impact on perinatal outcomes in twins.Methods: This prospective observational study was conducted in the department of obstetrics and gynecology, Government T. D. Medical College, Alappuzha, Kerala. A total of 106 cases of twin pregnancies were included in the prospective descriptive study. Based on the ultrasound results and methods of the postpartum pathologic examination of the placental membranes, the cases were divided into the twin group with monochorionic diamniotic (MCDA) and twin group with dichorionic diamniotic (DCDA group). The relationships of different chorionic properties and fetal outcomes were determined by comparing various fetal outcomes.Results: Among 106 twin pregnancies, 61.3% were DCDA twins, 38.7% were MCDA. Average maternal age of monochorionic twin was 25 and that of dichorionic twin was 27. Perinatal mortality of monochorionic twin was 14.7% when compared to 8.6% for dichorionic twin. The mean gestational age for monochorionic twin pregnancy was 34.78 weeks whereas it was 35.91 weeks for dichorionic pregnancy. Elective and emergency LSCS was done more for dichorionic twin pregnancies compared to monochorionic twin pregnancies. Low Apgar scores were seen in monochorionic twins compared to dichorionic twins.Conclusions: The incidence of fetal outcomes in the monochorionic group was inferior to those in the dichorionic group. The fetal outcomes may be improved by determining the chorionic properties in early pregnancy by using ultrasound and consequently planning for pregnancy monitoring and intervention.
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Chang, Yao-Lung, An-Shine Chao, Hsiu-Huei Peng, et al. "Increased Fetal Plasma Erythropoietin in Monochorionic Twin Pregnancies With Selective Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler." Twin Research and Human Genetics 19, no. 4 (2016): 383–88. http://dx.doi.org/10.1017/thg.2016.38.
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Hypoxia is the primary stimulus for the production of erythropoietin (EPO) in both fetal and adult life. Here, we investigated fetal plasma EPO concentrations in monochorionic (MC) twin pregnancies with selective intrauterine growth restriction (sIUGR) and abnormal umbilical artery (UA) Doppler. We diagnosed sIUGR in presence of (1) birth-weight discordance >20% and (2) either twin with a birth weight <10th percentile. An abnormal UA Doppler was defined as a persistent absent-reverse end diastolic flow (AREDF). The intertwin EPO ratio was calculated as the plasma EPO level of the smaller (or small-for-gestational-age) twin divided by the EPO concentration of the larger (or appropriate-for-gestational-age (AGA)) twin. Thirty-two MC twin pairs were included. Of these, 17 pairs were normal twins (Group 1), seven pairs were twins with sIUGR without UA Doppler abnormalities (Group 2), and eight pairs were twins with sIUGR and UA Doppler abnormalities (Group 3). The highest EPO ratio was identified in Group 3 (p< .001) but no significant differences were observed between Groups 1 and 2. Fetal hemoglobin levels did not differ significantly in the three groups, and fetal EPO concentration did not correlate with gestational age at birth. We conclude that fetal plasma EPO concentrations are selectively increased in MC twin pregnancies with sIUGR and abnormal UA Doppler, possibly as a result of uncompensated hypoxia.
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Witalisz, Władysław. "“I cluppe and I cusse as I wood wore”: Erotic Imagery in Middle English Mystical Writings." Text Matters, no. 3 (November 1, 2013): 58–70. http://dx.doi.org/10.2478/texmat-2013-0026.
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The mutual influences of the medieval discourse of courtly love and the literary visions of divine love have long been recognized by readers of medieval lyrical poetry and devotional writings. They are especially visible in the affinities between the language used to construct the picture of the ideal courtly lady and the images of the Virgin Mary. Praises of Mary’s physical beauty, strewn with erotic implications, are an example of a strictly male eroticization of the medieval Marian discourse, rooted in Bernard of Clairvaux’s allegorical reading of the Song of Songs, where Mary is imagined as the Bride of the poem, whose “breasts are like two young roes that are twins” (Cant. of Cant. 4:5). Glimpses of medieval female erotic imagination, also employed to express religious meanings, can be found in the writings of the mystical tradition: in England in the books of visions of Margery Kempe, in the anonymous seers of the fourteenth century, and, to some extent, in Julian of Norwich. Though subdued by patriarchal politics and edited by male amanuenses, the female voice can still be heard in the extant texts as it speaks of mystical experience by reference to bodily, somatic and, sometimes, erotic sensations in a manner different from the sensual implications found in the poetry of Marian adoration. The bliss of mystic elation, the ultimate union with God, is, in at least one mystical text, confidently metaphorized as an ecstatic, physical union with the human figure of Christ hanging on the cross.
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Canpolat, Fuat Emre, Murat Yurdakök, Ayse Korkmaz, Sule Yigit, and Gülsevin Tekinalp. "Birthweight Discordance in Twins and the Risk of Being Heavier for Respiratory Distress Syndrome." Twin Research and Human Genetics 9, no. 5 (2006): 659–63. http://dx.doi.org/10.1375/twin.9.5.659.
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AbstractTwin pregnancies are becoming common as a result of increased assisted reproduction. Studies have shown that the smaller twin of a pair is at greater risk of morbidity and mortality. Our aim was to determine if there is a relation between birth-weight discordancy and neonatal morbidity and mortality and to test the occurrence of respiratory distress syndrome (RDS) in discordant twins. For 5 years all twins admitted to our intensive care unit were included in the study. Discordance was calculated as the difference between twins' weights divided by the heavier weight. Diagnosis of RDS was made by typical clinical and radiographic methods. Multiple logistic regression was performed with gender, weight order and birth order as the independent variables and RDS as the dependent variable. Two hundred and sixty-six twin pairs with a mean gestation of 33 weeks and a mean birthweight of 1890 g were evaluated. Multiple logistic regression revealed that being the heavier twin was a more important risk factor for RDS (odds ratio 4.5; 95% confidence interval 2.2–9.2) than being the male or second-born twin. Based on neonatal outcomes a birthweight discordance equal or greater than 20% in twin pairs was accepted as the discordance criterion. Discordant and concordant groups were statistically different in neonatal mortality, necrotizing enterocolitis, polycytemia and hypoglycemia. Our data demonstrated that being the heavier twin is a risk factor for RDS and a birth-weight difference of 20% or more in twin pairs should be accepted as discordance.
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Robinson, Julian, Daniela Carusi, Sarah Little, and Sarah Easter. "The U.S. Twin Delivery Volume and Association with Cesarean Delivery Rates: A Hospital-Level Analysis." American Journal of Perinatology 35, no. 04 (2017): 345–53. http://dx.doi.org/10.1055/s-0037-1607316.
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Objective The objective of this study was to test whether hospitals experienced in twin delivery have lower rates of cesarean delivery for twins. Methods We divided obstetric hospitals in the 2011 National Inpatient Sample by quartile of annual twin deliveries and compared twin cesarean delivery rates between hospitals with weighted linear regression. We used Pearson's coefficients to correlate a hospital's twin cesarean delivery rate to its overall cesarean delivery and vaginal birth after cesarean (VBAC) rates. Results Annual twin delivery volume ranged from 1 to 506 across the 547 analyzed hospitals with a median of 10 and mode of 3. Adjusted rates of cesarean delivery were independent of delivery volume with a rate of 75.5 versus 74.8% in the lowest and highest volume hospitals (p = 0.09 across quartiles). A hospital's cesarean delivery rate for twins moderately correlated with the overall cesarean rate (r = 0.52, p < 0.01) and inversely correlated with VBAC rate (r = − 0.42, p < 0.01). Conclusion Most U.S. obstetrical units perform a low volume of twin deliveries with no decrease in cesarean delivery rates at higher volume hospitals. Twin cesarean delivery rates correlate with other obstetric parameters such as singleton cesarean delivery and VBAC rates suggesting twin cesarean delivery rate is more closely related to a hospital's general obstetric practice than its twin delivery volume.
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Wheeler, Lucy. "P019 Treating conjoined twins." Archives of Disease in Childhood 104, no. 7 (2019): e2.22-e2. http://dx.doi.org/10.1136/archdischild-2019-nppc.29.
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SituationD and M are conjoined twins born without an antenatal diagnosis and assessed as not suitable for separation. At the time of admission they were 21 months old with a combined weight of 17.1 Kg. D presented unwell with a raised heart rate and respiratory rate. A working diagnosis of sepsis (possibly urinary tract infection) was made. Advice was sought from pharmacy on the doses of ceftriaxone and paracetamol. Peripheral intravenous (IV) access was only available in twin M.BackgroundThe twins are joined side by side from the upper chest to the pelvis. They have separate heads, three arms and 2 legs. They have 2 hearts with a fused aorta, a shared liver, 2 gallbladders, 2 stomachs, 3 kidneys and a single bladder. D has a complex congenital heart condition and a poor prognosis. On admission, D was receiving propranolol, but M was not. The dose was based on the combined weight of the twins divided by 2. Conjoined twins are a rare phenomenon, occurring 1 in 50,000 to 100,000 births.1 Around 60% of these are stillborn or die shortly after birth. There are many different types of join with differences in shared organs and limbs. Consequently each twin pair is almost unique and consideration must be given as to how medication is dosed according to pharmacokinetic principles.OutcomeOpinion of the multidisciplinary team was that the twins have relatively separate circulations, although some cross-circulation would be expected. On admission, saturations in the right arm (twin D) were 75%. On the left side (twin M) this was 95%. Ceftriaxone is a highly protein bound, hydrophilic antibiotic,2 The degree of cross circulation (how much blood volume is shared between the twins) would affect the volume of distribution and hypoalbuminaemia was likely to increase the apparent volume of distribution. Based on this, ceftriaxone dosing was advised on the combined weight of the twins and given at 50 mg/Kg to M only. Ceftriaxone is excreted mainly unchanged in the urine and bile with little renal clearance or hepatic metabolism so this was not a concern. After 2 days, Ds CRP had reduced and the twins were switched to oral amoxicillin. Dosing was based on the combined weight of the twins and each was given half the dose. As each twin has a separate stomach, it was assumed relatively individual enteral absorption occurs. Ds CRP continued to drop and the twins were discharged home on day 4 with a further 3 days of oral amoxicillin. Paracetamol dosing was advised at 15 mg/kg based on the combined weight and half given to each twin. As required use was agreed, as there was uncertainty over the amount of hepatic metabolism that would occur by the twins shared liver.Lessons learntConjoined twins are a complex yet interesting challenge in terms of medication dosage and administration. There is a lack of evidence and dosing has been based on pharmacokinetic principles and adjusted according to clinical response.ReferencesOwolobi AT, Oseni SB, Sowande OA, et al. Dicephalus dibrachius dipus conjoined twins in a triplet pregnancy. Tropical Journal of Obstetrics and Gynaecology 2005;22:87–88.Electronic Medicines Compendium: Rocephin 1g powder for solution for injection or infusion - Summary of Product Characteristics. http://www.emc.org.uk/(Accessed 12 Jun 2018)
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Rönnemaa, Tapani, Jukka Marniemi, Markku J. Savolainen, et al. "Serum Lipids, Lipoproteins, and Lipid Metabolizing Enzymes in Identical Twins Discordant for Obesity." Journal of Clinical Endocrinology & Metabolism 83, no. 8 (1998): 2792–99. http://dx.doi.org/10.1210/jcem.83.8.4998.
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abstract Obesity is associated with adverse changes in plasma lipoprotein metabolism, but it is not known completely how this association is modified by genetic factors. We assessed the contribution of obesity to serum lipid and lipoprotein levels and lipid metabolizing enzyme activities by examining 23 identical twin pairs (9 male, 14 female) who had, on the average, an 18-kg intrapair difference in BW. Compared with lean co-twins, obese co-twins had approximately 20% higher low-density lipoprotein (LDL) cholesterol (P &lt; 0.01), 20% lower high-density lipoprotein2 cholesterol (P = 0.010), and 90% (men) or 35% (women) higher (P ≤ 0.06) total, very-low-density lipoprotein and LDL triglycerides. The pairs were divided into subgroups by the gender-specific median value of abdominal visceral fat (AVF) area in the obese co-twin and by apolipoprotein E 4 phenotype. The intrapair differences in serum cholesterol fractions were similar in twin pairs with high or low AVF, whereas only high AVF pairs showed significant differences in triglyceride fractions. The greatest intrapair differences in total, very-low-density lipoprotein and LDL triglycerides were observed in apolipoprotein E 4-positive pairs expressing high AVF. Compared with lean co-twins, lecithin cholesterol acyltransferase activity was 18% higher (P &lt; 0.001) and hepatic lipase activity was 38% higher (P = 0.016) in obese co-twins with high AVF. When genetic factors are identical, obesity is associated with an atherogenic lipid profile, especially in subjects with high visceral fat accumulation.
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Yang, Hyoin, Young Sik Choi, Ka Hyun Nam, Ja Young Kwon, Yong Won Park, and Young Han Kim. "Obstetric and Perinatal Outcomes of Dichorionic Twin Pregnancies According to Methods of Conception: Spontaneous Versus In-Vitro Fertilization." Twin Research and Human Genetics 14, no. 1 (2011): 98–103. http://dx.doi.org/10.1375/twin.14.1.98.
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We have observed the inconsistent findings from various studies on twin pregnancy outcomes obtained by assisted reproductive technology and spontaneous conception. In most studies, however, the concrete chorionicity, regarded as a confounding factor for predicting the perinatal outcomes of twin pregnancies, has not been determined. The purpose of this study was to compare obstetric and perinatal outcomes of only the dichorionic twin pregnancies according to the methods of conception: spontaneous and in-vitro fertilization (IVF). The twin pairs with dichorionicity reported from 1995 to 2008 were investigated and we divided them into two groups which consisted of 286 and 134 twins by spontaneous conception and IVF, respectively. Odds ratios for associations between IVF and pregnancy outcomes were analyzed after adjustment for maternal age and parity. There were no risk differences between the two groups regarding the obstetric complications, which include preterm delivery, preterm labor, preterm premature rupture of membranes, preeclampsia, placenta previa, and abruption. Any differences were not shown in the two groups for the risk estimates of perinatal outcomes, such as low birthweight, very low birthweight, small for gestational age, Apgar scores of < 7 at 5 minutes, discordance in birthweights, congenital anomalies and mortality. However, twins conceived after IVF were less likely to be admitted to the neonatal intensive care unit than those conceived spontaneously (adjusted OR 0.488; 95% confidence interval 0.261–0.910). In the cases of dichorionic twins, IVF may not be associated with adverse perinatal and obstetric outcomes compared with spontaneous conception.
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Schneuber, Susanne, Eva Magnet, Josef Haas, et al. "Twin-to-Twin Delivery Time: Neonatal Outcome of the Second Twin." Twin Research and Human Genetics 14, no. 6 (2011): 573–79. http://dx.doi.org/10.1375/twin.14.6.573.
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Objective: To examine the effect of twin-to-twin delivery time (TTDT) on neonatal outcome. Methods: We evaluated twin deliveries >34 weeks of gestation. Twin pregnancies with both twins delivered by cesarean section and pregnancies with antenatal complications were excluded. We analyzed TTDT and neonatal outcomes of the second twin (umbilical arterial pH value (pHart), Apgar scores at 1, 5 and 10 minutes, need for intensive care). The study population was divided into two homogenous groups based on the mode of delivery: (A) vertex presentation and vaginal delivery of both twins, (B) vertex presentation and vaginal or vaginal operative delivery of twin I, breech or transverse presentation and vaginal breech delivery or cesarean section (CS) of twin II. Results: A total of 207 twin pairs were included in our study. In Group A (n = 151) there were no significant correlations between TTDT and pHart or Apgar scores at 1, 5 and 10 minutes of twin II (p = .156; 0.861; 0.151 and 0.384, respectively). In Group B (n = 56), the mean pHart of twin II was inversely correlated to TTDT, but not significantly (p = .417). TTDT was inversely related to 1-min and 5-min Apgar scores, but not significantly (p = .330; p = .138, respectively). The 10-min Apgar score showed no correlation with TTDT (p = .638). Conclusion: Increasing TTDT was not associated with adverse fetal outcome. Expectant management of the second twin appears possible and elapsed time alone does not appear to be an indication for intervention.
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Charlemaine, C., M. Duyme, F. Guis, et al. "Twin Differences and Similarities of Birthweight and Term in the French Romulus Population." Acta geneticae medicae et gemellologiae: twin research 47, no. 1 (1998): 1–12. http://dx.doi.org/10.1017/s0001566000000325.
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AbstractThis study was performed to examine the main characteristics of the French Romulus twin population: zygosity, chorionicity, sex, term and birthweight. A sample of 104 pairs of twins was distinguished by zygosity, chorionicity and sex, and divided into concordant and discordant birthweight groups. Fifty-three % (n = 55) of the fetus pairs studied were born at “ideal term” (35-38 weeks), and 25% (n = 26) were delivered at “preterm” (28-34 weeks). The very preterm (< 28 weeks), and “postterm” (> 38 weeks) represented altogether 22% (n = 23) of the sample. Of the 104 twin pairs, 68% (n = 71) differ by less than 15% in birthweight, and 32% (n = 33) have a birthweight difference higher than 15%. In dizygotic (DZ) pairs females had more tendency to be in the discordant group (p = 0.01) while in monochorionic-monozygotic (MC-MZ) pairs males were more discordant (p = 0.07). We found a significant interaction between sex and zygosity type (p = 0.02). Males had a birthweight difference significantly weaker than that of females in dichorionic-monozygotic (DC-MZ) and DZ twins whereas it was higher than that of females in MC-MZ twins. There were no MZ twin pairs with DC placentation over than 15% birthweight difference. Log linear analysis demonstrated a three-way interaction (p < 0.05) between term type, zygosity type and hypotrophy. Our data indicate that in the group of twins born between 35 and 38 weeks' gestation the crucial question still remains unsettled on how term and birhweight are related to zygotism and/or chorionicity.
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Lykken, David T. "A More Accurate Estimate of Heritability." Twin Research and Human Genetics 10, no. 1 (2007): 168–73. http://dx.doi.org/10.1375/twin.10.1.168.
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AbstractAll psychological and psychophysiological traits vary, often widely, about their stable set-point values, due to transitory environmental influences. Because it is this stable set-point that embodies the genetically determined component of the trait, twin and family data based on one-time trait measurements must underestimate true trait heritability. The means of multiple measurements, taken months or years apart, then correlated within pairs of monozygotic twins, would yield an accurate estimate of the broad heritability of the set-point value, but such data are rare and expensive. Given just two measurements sufficiently far apart, the cross-twin cross-time correlation (RCT), divided by the retest or within-twin cross-time correlation (RWT), provides a valid estimate of set-point heritability. This article examines data from young and middle-aged twins who were tested twice, 3 or more years apart, on heart rate and blood pressure, personality traits, self-rating items, occupational and recreational interests, as well as on Wechsler Intelligence Scales. In every case, the disattenuated RCT revealed substantially higher heritability than indicated by correlations based on single measurements.
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KENDLER, KENNETH S., STEVEN H. AGGEN, CAROL A. PRESCOTT, KRISTEN C. JACOBSON, and MICHAEL C. NEALE. "Level of family dysfunction and genetic influences on smoking in women." Psychological Medicine 34, no. 7 (2004): 1263–69. http://dx.doi.org/10.1017/s0033291704002417.
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Background. An adoption study of alcoholism suggests that in women, the impact of genetic risk factors become greater in the presence of conflict in the family of origin. Is the same true for cigarette smoking (CS)?Method. We obtained, in a sample of 1676 twins from female–female twin pairs from a population-based register, a measure of maximum lifetime CS (divided into six ordinal categories) and family dysfunction (FD) assessed as the mean report of up to four informants (twin, co-twin, mother, father). Statistical analysis was conducted by traditional regression analysis and a moderator structural equation twin model using the computer program Mx.Results. With increasing levels of FD, maximum CS increased substantially while correlations for CS in monozygotic (MZ) and dizygotic (DZ) twins decreased modestly. Regression analyses demonstrated reduced twin-pair resemblance for CS with increasing levels of FD. The best-fit structural equation model found high levels of heritability for CS and no evidence for a role of shared environment. With increasing levels of FD, the proportion of variance in CS due to genetic factors (i.e. heritability) decreased while that due to unique environmental effects increased.Conclusions. Several different statistical methods suggested that, contrary to prediction, heritability of CS decreased rather than increased with higher levels of dysfunction in the family of origin. The hypothesis that genetic effects for psychiatric and drug-use disorders become stronger in more adverse environments is not universally true.
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Barbero, A., C. Porcu, A. Spezzigu, et al. "Changes in renal hemodynamics of undernourished fetuses appear earlier than IUGR evidences." Journal of Developmental Origins of Health and Disease 9, no. 3 (2018): 338–43. http://dx.doi.org/10.1017/s204017441800003x.
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AbstractThe present study used a sheep model of intrauterine growth restriction, combining maternal undernutrition and twinning, to determine possible markers of early damage to the fetal kidney. The occurrence of early deviations in fetal hemodynamics which may be indicative of changes in blood perfusion was assessed by Doppler ultrasonography. A total of 24 sheep divided in two groups were fed with the same standard grain-based diet but fulfilling either their daily maintenance requirements for pregnancy (control group; n=12, six singleton and six twin pregnancies) or only the 50% of such quantity (food-restricted group; n=12; four singleton and eight twin pregnancies). All the fetuses were assessed by both B-mode and Doppler ultrasonography at Day 115 of pregnancy. Fetal blood supply was affected by maternal undernutrition, although there were still no evidences of brain-sparing excepting in fetuses at greatest challenge (twins in underfed pregnancies). However, there were early changes in the blood supply to the kidneys of underfed fetuses and underfed twins evidenced decreases in kidney size.
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Voracek, Martin, and Tanja Haubner. "Twin—Singleton Differences in Intelligence: A Meta-Analysis." Psychological Reports 102, no. 3 (2008): 951–62. http://dx.doi.org/10.2466/pr0.102.3.951-962.
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Since the emergence of twin studies in the 1920s, time and again the question of possible twin-singleton differences in intelligence has been posed. This study addressed the issue through a meta-analysis of published studies on this theme. Twins on the average seem to have lower IQs than singletons. The best estimate for this group difference is 4.2 IQ points (less than one-third of a standard deviation), with a great divide between study outcomes of less vs more recent birth cohorts (5.1 vs 0.5 IQ points, respectively). The evidence is based on studies from six countries (including population-based ones of entire birth cohorts), a massive database (comparisons of more than 30,000 twins with nearly 1.6 million singletons), a variety of intelligence tests, and birth cohorts spanning most of the 20th century, but, for the most part, on an age range limited to children and adolescents. The effect shows considerable between-study heterogeneity but appears robust (fail-safe N calculations), not due to influential individual studies (sensitivity analysis) or publication bias, was present since the very first published studies (cumulative meta-analysis), and appears generalizable across sex, zygosity, and other intelligence domains beyond the verbal. There are insufficient data as to whether the effect persists over the lifespan, exists as well within families, or has ceased in recent birth cohorts of highly developed countries (Denmark and The Netherlands). Likely causes of the effect appear to be prenatal and perinatal factors (reduced fetal growth and shorter gestation for twins).
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Zhang, Jin-Wen, Ware Branch, Matthew Hoffman, et al. "In which groups of pregnant women can the caesarean delivery rate likely be reduced safely in the USA? A multicentre cross-sectional study." BMJ Open 8, no. 8 (2018): e021670. http://dx.doi.org/10.1136/bmjopen-2018-021670.
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ObjectivesTo identify obstetrical subgroups in which (1) the caesarean delivery (CD) rate may be reduced without compromising safety and (2) CD may be associated with better perinatal outcomes.DesignA multicentre cross-sectional study.Setting19 hospitals in the USA that participated in the Consortium on Safe Labor.Participants228 562 pregnant women in 2002–2008.Main outcome measuresMaternal and neonatal safety was measured using the individual Weighted Adverse Outcome Score.MethodsWomen were divided into 10 subgroups according to a modified Robson classification system. Generalised estimated equation model was used to examine the relationships between mode of delivery and Weighted Adverse Outcome Score in each subgroup.ResultsThe overall caesarean rate was 31.2%. Repeat CD contributed 29.5% of all CD, followed by nulliparas with labour induction (15.3%) and non-cephalic presentation (14.3%). The caesarean rates in induced nulliparas with a term singleton cephalic pregnancy and women with previous CD were 31.6% and 82.0%, respectively. CD had no clinically meaningful association with perinatal outcomes in most subgroups. However, in singleton preterm breech presentation and preterm twin gestation with the first twin in non-cephalic presentation, CD was associated with substantially improved maternal and perinatal outcomes.ConclusionsWomen with repeat CD, term non-cephalic presentation, term twins or other multiple gestation and preterm births may be the potential targets for safely reducing prelabour CD rate, while nulliparas or multiparas with spontaneous or induced labour, women with repeat CD, term non-cephalic presentation, term twins or other multiple gestation and preterm births are potential targets for reducing intrapartum CD rate without compromising maternal and neonatal safety in the USA. On the other hand, CD may still be associated with better perinatal outcomes in women with singleton preterm breech presentation or preterm twins with the first twin in non-cephalic presentation.
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Martin, N. G., U. Kehren, D. Battistutta, and J. D. Mathews. "Iatrogenic Influences on the Heritability of Childhood Tonsillectomy: Cohort Differences in Twin Concordance." Acta geneticae medicae et gemellologiae: twin research 40, no. 2 (1991): 165–72. http://dx.doi.org/10.1017/s0001566000002609.
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AbstractIn 1980-82, a mailed questionnaire was completed by 3,810 pairs of adult twins enrolled on the Australian NH&MRC Twin Register. Twins were asked whether they had had their tonsils out and, if so, at what age. The sample was divided into four birth cohorts of approximately equal size, and only childhood tonsillectomy (to the age of 18) was considered. The prevalence of tonsillectomy differed markedly between cohorts, being highest in those born in the 1940s and early 1950s. Within each cohort, the prevalence was very similar in MZ and DZ twins, yet concordance was much higher in MZ twins, indicating the importance of genetic factors in predisposition to tonsillectomy. However, the proportions of variance in liability due to genetic and shared environmental factors differed markedly between cohorts. In the 1950s, when tonsillectomy was fashionable, shared environment accounted for 60% of variance and genetic factors for only 29%. However, by the early 1960s, when tonsillectomy was going out of fashion, heritability was up to 0.82 and shared environment accounted for only 10% of variance. Our results illustrate, once again, that heritability is not a constant, but depends on the precise characteristics of the population and the time at which it is studied.
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Bucholz, Richard D., Kong-Woo Yoon, and Raymond E. Shively. "Temporoparietal craniopagus." Journal of Neurosurgery 66, no. 1 (1987): 72–79. http://dx.doi.org/10.3171/jns.1987.66.1.0072.
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✓ A case of craniopagus twins joined in the temporoparietal area is presented, along with a review of the literature on craniopagus. A large area of brain was shared between the neurologically normal infants, with defects in the scalp, skull, and dura. The twins were separated in a three-step procedure. First, areas of shared brain were divided and separated with silicone sheets. The second procedure consisted of the insertion of scalp expanders to allow primary skin closure. In the third procedure complete separation was performed which was complicated by severe hypotension in one infant that was due to dural sinus hemorrhage. Cerebrospinal fluid leak was the most difficult problem encountered in the postoperative period; this was treated with lumboperitoneal and ventriculoperitoneal shunts. After 2 years, one twin is neurologically normal; the other is severely developmentally delayed, possibly related to the severe hypotension experienced during the third procedure. A review of the literature on craniopagus is presented. Analysis of data in the literature suggests that the area involved in the craniopagus as well as the venous connections are closely related to survival following separation of craniopagus twins.
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Devlieger, Roland G. L., Thomas Demeyere, Jan A. Deprest, et al. "Ultrasound Determination of Chorionicity in Twin Pregnancy: Accuracy and Operator Experience." Twin Research 4, no. 4 (2001): 223–26. http://dx.doi.org/10.1375/twin.4.4.223.
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AbstractTo evaluate the accuracy of ultrasound in early detection of chorionicity and amnionicity in twin pregnancies and evaluate the role of operator-experience, a prospective follow up of 87 consecutive twin pregnancies was performed. Chorionicity and amnionicity were determined by 17 different observers, divided in 2 groups on the basis of their experience, using a composite of US markers at the first US examination confirming a viable intrauterine twin pregnancy. Accuracy of prediction was determined for both groups by comparison with postnatal pathology. From the 87 pregnancies examined at 10.1 (minimum 5.5 weeks, maximum 26.0) weeks of gestation, pathology was available in 82 cases and a correct prediction of chorionicity was made in all but two cases, both being diagnosed as monochorionic while dichorionic by observers belonging the more experienced group. No monochorionic pregnancy was missed and amnionicity was correctly diagnosed in all cases, including two monoamniotic twins. We conclude that use of a composite of ultrasound markers for early detection of chorionicity and amnionicity is reliable in a clinical setting where physicians with a variable degree of experience perform ultrasound examination.
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Bhandari, Shilpa, Pallavi Agrawal, Ishita Ganguly, Aparna Singh, and Nitika Gupta. "Perinatal Outcome in Assisted Reproductive Pregnancies: Comparative Analysis of Reduced versus Unreduced Gestation." International Journal of Reproductive Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7504609.
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Objectives. This study aims to evaluate perinatal outcomes such as gestational age at delivery and live birth rate in singleton and twin gestation with or without fetal reduction. Method. A retrospective analysis was done on patients which were divided into reduced and unreduced groups on the basis of order of reduction of one or more fetuses between 6 and 13 weeks of gestation. Patients records were studied to note gestational age at delivery/abortion, birth weight, and neonatal outcome. Result. The cohort included a total of 292 patients: 102 singletons and 190 twins. 52 pregnancies were reduced in singleton cohort and 68 were reduced in twin cohort. No statistical difference was observed in live birth rate, gestational age at delivery, and birth weight and significant higher incidence of IUGR was observed in reduced and unreduced twin gestation. In singleton pregnancies however preterm delivery rate increased with fetal reduction. Conclusion. Although reduction does not reduce the live birth rate, it does reduce gestation age of delivery and birth weight of newborn. This effect is more apparent when multiple gestation is reduced to singleton.
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WANG, GUOYONG, ZHONGHAO JIANG, and JIANSHE LIAN. "ENHANCED TENSILE DUCTILITY IN AN ELECTRODEPOSITED CU WITH NANO-SIZED GROWTH TWINS." International Journal of Modern Physics B 24, no. 15n16 (2010): 2537–42. http://dx.doi.org/10.1142/s0217979210065222.
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A fully dense electrodeposited microcrystalline copper with nano-scale twins was synthesized by electrodeposition. The microstructure of this copper was analyzed X-ray diffractometer (XRD) and by transmission electron microscopy (TEM). The grains of mean size about 2mm were divided by high density of growth twins with mean lamellar thickness of about 90 nm. Tensile tests at different strain rates and room temperature showed that the strength increased from 379 MPa to 458 MPa with strain rate increasing from 10-5 s-1 to 0.1 s-1. The elongations to fracture were in the range of 13.6~15.5%. So this Cu has good combination of strength and ductility. The strengths are much higher than that determined by Hall-Petch relation with the same grain size, which means that twin boundaries are effective in blocking dislocation motion. The strain rate sensitivity and activation volume estimated from the flow stress versus strain curves was 0.016 and 84 b3~69b3, respectively. Such a large activation volume indicates that the deformation of this copper was controlled by dislocation process.
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Andrew, Martin, Peter McGuffin, and Randy Katz. "Genetic and non-genetic subtypes of major depressive disorder." British Journal of Psychiatry 173, no. 6 (1998): 523–26. http://dx.doi.org/10.1192/bjp.173.6.523.
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BackgroundWe aimed to examine the hypotheses that major depression is aetiologically heterogeneous consisting of a mixture of ‘genetic’ and ‘non-genetic’ forms or, alternatively, a mixture of one form that is ‘pure’ depression and another that has a familial relationship with alcohol dependency or other disorders.MethodOne hundred and eleven twin pairs (44 monozygotic, 67 dizygotic) where the proband had received treatment for DSM–IV major depression were ascertained via a hospital register. Family history information on parents and siblings was obtained from the proband, co-twin or both. Diagnoses on parents and siblings were made blind to twin zygosity or concordance and compared in the relatives of concordant versus discordant twins.ResultsThe lifetime prevalence and age-corrected risk of depression were no different in the relatives of concordant and discordant twin pairs. There was a marginally significant increase in the rate of alcohol abuse or dependence among the relatives of concordant twins but no difference between concordant and discordant pairs in respect of other axis I diagnosis among family members.ConclusionsThe results argue against genetic heterogeneity and suggest that major depression cannot usefully be divided into genetic and non-genetic forms or into ‘pure’ depression and depression associated with other disorders such as alcohol dependency.
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Alia-García, Esther, Manuel Ponce-Alonso, Claudia Saralegui, et al. "Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children." Diagnostics 11, no. 5 (2021): 835. http://dx.doi.org/10.3390/diagnostics11050835.
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In recent years, the etiology of caries has evolved from a simplistic infectious perspective based on Streptococcus mutans and/or Lactobacillus activity, to a multifactorial disease involving a complex oral microbiota, the human genetic background and the environment. The aim of this work was to identify bacterial markers associated with early caries using massive 16S rDNA. To minimize the other factors, the composition of the oral microbiota of twins in which only one of them had caries was compared with their healthy sibling. Twenty-one monozygotic twin pairs without a previous diagnosis of caries were recruited in the context of their orthodontic treatment and divided into two categories: (1) caries group in which only one of the twins had caries; and (2) control group in which neither of the twins had caries. Each participant contributed a single oral lavage sample in which the bacterial composition was determined by 16S rDNA amplification and further high-throughput sequencing. Data analysis included statistical comparison of alpha and beta diversity, as well as differential taxa abundance between groups. Our results show that twins of the control group have a closer bacterial composition than those from the caries group. However, statistical differences were not detected and we were unable to find any particular bacterial marker by 16S rDNA high-throughput sequencing that could be useful for prevention strategies. Although these results should be validated in a larger population, including children from other places or ethnicities, we conclude that the occurrence of caries is not related to the increase of any particular bacterial population.
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Chang, Yao-Lung, Shuenn-Dyh Chang, An-Shine Chao, Reyin Lien, Po-Jen Cheng, and Ho-Yen Chueh. "Low Rate of Cerebral Injury in Monochorionic Twins With Selective Intrauterine Growth Restriction." Twin Research and Human Genetics 13, no. 1 (2010): 109–14. http://dx.doi.org/10.1375/twin.13.1.109.
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AbstractThis study was conducted to determine the incidence of cerebral injury as detected by postnatal brain scan in monochorionic twins with selective intrauterine growth restriction. Having excluded cases complicated with twin-to-twin transfusion syndrome and one co-twin suffering intrauterine fetal death, a total of 73 monochorionic twin pregnancies divided into absence (group I,n= 46) or presence (group II,n= 27) of selective intrauterine growth restriction. Mild cerebral injury was defined as presenting one of the following abnormal cranial scan findings: intraventricular hemorrhage grade I, grade II, lenticulostiate vasculopathy and/or subependymal pseudocysts, while severe cerebral injury was defined as presenting intraventricular hemorrhage grade III, grade IV, cystic periventricular leukomalacia (PVL) grade II or higher, porencephalic cysts, and/or ventricular dilatation. The incidence of mild cerebral injury was not significantly different between these two groups (eight cases in group I and six cases in group II). Except for one case that later developed a seizure, the majority (13 out of 14) of cases with minor brain scan anomalies were only transient, without significant clinical impact. There was only one case diagnosed with a major brain scan anomaly (periventricular leukomalacia) in group II. One severe brain injury and three neonatal deaths all belonged to group II with abnormal umbilical artery Doppler in the growth restricted twin. In conclusion, the incidence of severe cerebral injury in monochorionic twin pregnancies with selective intrauterine growth restriction was low, at 3.7%.
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Park, Jeong Woo, Seung Mi Lee, Hye-Sim Kang, Soon-Sup Shim, and Jong Kwan Jun. "Spontaneous Version of Fetal Presentation in Twin Pregnancies During Third Trimester: Longitudinal Assessment." Twin Research and Human Genetics 21, no. 3 (2018): 269–74. http://dx.doi.org/10.1017/thg.2018.24.
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Little is known about longitudinal changes of the first twin presentation in twin gestations. This is a retrospective cohort study including 411 women who were admitted consecutively and delivered live-born twins at 36 weeks of gestation or more. Longitudinal assessment of the first twin presentation was conducted during gestation and at birth in all cases. Gestational age at antenatal assessment was divided into two intervals: early-third trimester (28–31 weeks) and mid-third trimester (32–35 weeks). Fetal presentation was categorized as vertex or non-vertex. We analyzed change of fetal presentation between antepartum intervals and birth. First twin presentation at early-third trimester had the same presentation at birth in 87.6% (360/411) of the study population. In this ‘no change’ group, vertex presentation was seen in 95.6% (283/296) and non-vertex was seen in 67.0% (77/115) of cases. In total, 96.1% (395/411) of the study population maintained their presentation between mid-third trimester and birth. Vertex presentation was seen in 98.4% (310/315) and non-vertex was seen in 88.5% (85/96) of cases. When comparing vertex with non-vertex, vertex presentation during third trimester was a more reliable predictor of presentation at birth (p < .001). The only factor that contributed significantly to spontaneous version of the first twin during mid-third trimester and birth was a lower birth weight of the first twin compared with the second twin. In conclusion, first twin presentation with vertex during third trimester is not likely to change into non-vertex at birth. We concluded that vertex presentation in twin gestations at early- and mid-third trimester is very predictable. In contrast, a non-vertex first twin presentation is relatively unstable.
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Hannukainen, Jarna C., Urho M. Kujala, Jyri Toikka, et al. "Cardiac structure and function in monozygotic twin pairs discordant for physical fitness." Journal of Applied Physiology 99, no. 2 (2005): 535–41. http://dx.doi.org/10.1152/japplphysiol.00107.2005.
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Cross-sectional studies in athletes and untrained subjects suggest that exercise training induces adaptations in cardiac structure and function. However, the role of genetic variation on the results has largely been ignored in these studies. The purpose of this study was to investigate the effects of long-term volitionally increased physical activity on electrocardiographic and echocardiographic parameters in male monozygotic twin pairs discordant for physical activity and fitness. On the basis of the mailed questionnaires, a telephone interview, and the inclusion criteria, 12 pairs of young adult male monozygotic twins were recruited from a Finnish twin cohort. All subjects completed a maximal oxygen uptake (V̇o2 max) test and electrocardiography and echocardiography studies. Nine pairs had at least 9% difference in V̇o2 max and were selected for further analysis and for a second echocardiography study. Twins were divided into the more (MAG) and less active group (LAG), according to their V̇o2 max. On average, MAG had 18% higher V̇o2 max compared with LAG. In electrocardiography, MAG had 29% ( P = 0.02) higher Cornell voltage and 37% ( P = 0.01) higher right-side hypertrophy index. In echocardiography, no significant differences were observed between the groups, and left ventricular mass index was only 7% ( P = 0.16) higher in MAG. These results show that the volitionally increased physical activity that has led to an 18% increase in cardiorespiratory fitness induces greater changes in electro- than echocardiographic parameters. Electrocardiographic changes were suggestive of left ventricular hypertrophy, and echocardiography showed a similar but statistically nonsignificant trend.
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Perek-Nowak, Małgorzata, and Marek S. Szczerba. "Structure Refinement Induced by Deformation Twinning in 77K Tensile Cu-8%at.Al Single Crystals." Materials Science Forum 674 (February 2011): 61–69. http://dx.doi.org/10.4028/www.scientific.net/msf.674.61.
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In the paper the concept of structure refinement due to mechanical twinning is discussed. It is postulated that the process of structure refinement may occur when dominant crystal shear proceeds across twin-matrix interface (Mode 2). Contrary, if the crystal shear proceeds parallel to the interface (Mode 1) no condition for structure refinement is satisfied. The conditions of the structure refinement and no structure refinement are shown taking example of tensile Cu-8%at. Al single crystals of two orientations [1 4 5] and [1 1 2] tested in liquid nitrogen. The tensile characteristics are therefore divided into stages associated with the Mode 1 and Mode 2, which correspond to the fact whether refinement of single crystal structure is present or not, as it is proved by the EBSD analysis. The performed analysis showed that structure refinement consists of formation of regions of new orientations, where the most common feature is the II order twinning (the case [1 4 5]) supported by other regions of specific orientations necessary to accommodate mainly the transfer of crystal twin shear across the twin-matrix interface. Moreover, if the II order twinning plays the dominating function (the case [1 1 2]) higher order twins are to bring into operation to assure further ductility of a deformed sample.
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Manjusha, KK, K. Jyothindrakumar, A. Nishad, and K. Madhav Manoj. "Growth and Development of Dentofacial Complex influenced by Genetic and Environmental Factors using Monozygotic Twins." Journal of Contemporary Dental Practice 18, no. 9 (2017): 754–58. http://dx.doi.org/10.5005/jp-journals-10024-2121.
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ABSTRACT Aim The purpose of this study was to determine the possible effects of genetic and environmental factors on dentofacial complex using monozygotic twins. Materials and methods The study sample was made of 21 pairs of monozygotic twins (14 female pairs and seven male pairs) between 10 and 25 years. Pretreatment lateral cephalograms were used which were traced and digitized, and various landmarks to determine the anteroposterior and vertical proportions were marked. Samples were divided into two groups. The correlation between groups was found by calculating Pearson's product moment correlation coefficients. Results The range of the correlation coefficient was from 0.705 to 0.952. Gonial angle showed the highest correlation coefficient (0.952), while saddle angle showed the lowest correlation coefficient (0.705). Conclusion The growth and development of craniofacial complex is under mutifactorial control. However, genetic influences do tend to play a dominant role. Clinical significance By studying identical twins, we can study about the interaction of the environment with the genes and how it affects the growth and development of the body in general and dentofacial complex in particular. By utilizing twin studies, we can identify whether a particular trait, disease, or disorder is influenced more strongly by genetics or by the environment. Success of orthodontic treatment depends on a proper diagnosis of the problem including its etiological factors. Genetic studies let the orthodontists to understand the effects of genetic and environmental factors in the growth and development of dentofacial complex better and allows to prevent or treat malocclusions and skeletal anomalies in better ways. How to cite this article Manjusha KK, Jyothindrakumar K, Nishad A, Manoj KM. Growth and Development of Dentofacial Complex influenced by Genetic and Environmental Factors using Monozygotic Twins. J Contemp Dent Pract 2017;18(9):754-758.
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Pasquini, Lucia, Silvia Conticini, Tiziana Tomaiuolo, et al. "Application of Umbilical Artery Classification in Complicated Monochorionic Twins." Twin Research and Human Genetics 18, no. 5 (2015): 601–5. http://dx.doi.org/10.1017/thg.2015.54.
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We report our experience on the application of Gratacos’ classification in a cohort of monochorionic pregnancies complicated by selective intra-uterine growth retardation based on the Doppler assessment of the umbilical artery. Materials and methods: A retrospective study was conducted on 52 cases of monochorionic twin pregnancies, in which one twin presented an abdominal circumference at or below the 10th percentile for gestational age. Cases were classified into three types according to the umbilical artery Doppler in the smaller twin. Subsequently, patients were divided into two groups: the selective IntraUterine Growth Retardation group and the Twin-to-Twin Transfusion Syndrome (TTTS) group. Results: Of the total 52 cases, 37 were classified as Type I, 12 as Type II, and 3 as Type III cases. In the total group, progressive fetal deterioration of the smaller fetus requiring active management was observed in 66.7% of Type II and 11.1% of Type I cases (p < .001), and in no Type III case. Unexpected fetal death of the smaller twin was observed more frequently in Type III (two cases, 66.7%) than in Types I and II cases (5% and 33%, respectively). Among the 52 cases, TTTS with oligo-polyhydramnios sequence was diagnosed in 10 cases. The remaining 42 cases were therefore defined as selective intra-uterine growth retardation. In the selective IntraUterine Growth Retardation group, results were similar to those obtained for the whole population. Conclusions: Classification of complicated monochorionic twins based on the umbilical artery Doppler is particularly important for counseling, even when we include TTTS cases, and permits the prediction of clinical evolution and perinatal outcome.
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Sung, Su Jin, Seung Mi Lee, Sohee Oh, et al. "Mid-pregnancy cervical length as a risk factor for cesarean section in women with twin pregnancies." Journal of Perinatal Medicine 46, no. 7 (2018): 780–85. http://dx.doi.org/10.1515/jpm-2017-0302.
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Abstract Objective: It is well known that a short cervix at mid-pregnancy is a risk factor for spontaneous preterm birth in both singleton and twin gestations. Recent evidence also suggests that a long cervix at mid-pregnancy is a predictor of the risk of cesarean section (C/S) in singleton gestation. The purpose of this study was to determine whether a long cervix at mid-pregnancy was associated with an increased risk of C/S in women with twin pregnancies. Methods: We enrolled 746 women pregnant with twins whose cervical length was measured by trans-vaginal ultrasonography at a mean of 22 weeks of gestation and who delivered in our institution. Cases with a short cervix [cervical length (CL) <15 mm] were excluded. Cases were divided into four groups according to the quartile of CL. Results: The rate of C/S increased according to the quartile of CL (47% in the 1st quartile, 51% in the 2nd quartile, 56% in the 3rd quartile and 62% in the 4th quartile, P<0.005, χ2 for trend). CL was an independent risk factor for C/S even after adjustment for confounding variables. When confining analysis to women who delivered after a trial of labor (n=418), to nulliparous women (n=633) or to those who delivered at late preterm or full term (n=666), the rate of C/S also increased according to the quartile of CL, and the relationship between CL and the risk of C/S remained significant after adjustment in each group. Conclusion: In women pregnant with twins, long CL at mid-pregnancy was a risk factor for C/S.
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Luke, Barbara, Morton B. Brown, Ruta B. Misiunas, et al. "The Hispanic Paradox in Twin Pregnancies." Twin Research and Human Genetics 8, no. 5 (2005): 532–37. http://dx.doi.org/10.1375/twin.8.5.532.
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AbstractThe objective of this study was to compare length of gestation, fetal growth, and birthweight by race/ethnicity and pregravid weight groups in twin pregnancies. Three thousand and thirty-six twin pregnancies of 28 weeks or more gestation were divided by race/ethnicity (White, Black and Hispanic), and pregravid body mass index (BMI) groups (less than 25.0 vs. 25.0 or more). Outcomes were modeled using multiple regression, controlling for confounders, with White non-Hispanic women as the reference group. Hispanic women had the highest average birthweight and the longest gestation, as well as the lowest proportions of low birthweight, very low birthweight, preterm and early preterm births of the 3 race/ethnicity groups. In the multivariate analyses, Hispanic women had significantly longer gestations (by 7.8 days) and faster rates of fetal growth midgestation (20 to 28 weeks, by 17.4 g/week) and late gestation (after 28 weeks, by 5.3 g/week), whereas Black women had significantly slower rates of fetal growth (by 5.7 g/week and by 4.5 g/week, respectively). These findings in twins reflect the racial and ethnic disparities previously shown in singletons, including the Hispanic paradox of longer gestations and higher rates of fetal growth.
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KENDLER, K. S., K. SHETH, C. O. GARDNER, and C. A. PRESCOTT. "Childhood parental loss and risk for first-onset of major depression and alcohol dependence: the time-decay of risk and sex differences." Psychological Medicine 32, no. 7 (2002): 1187–94. http://dx.doi.org/10.1017/s0033291702006219.
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Background. Whereas a number of studies have suggested that parental loss is associated with increased risk for major depression (MD), much less is known about possible gender differences, diagnostic specificity and the time course of the impact of loss.Method. First-onsets for MD and alcohol dependence (AD) were assessed at personal interviews in 5070 twins from same-sex (SS) and 2118 from opposite-sex (OS) twin pairs ascertained from a population-based registry. Cox Proportional Hazard (PH) and Non-Proportional Hazard (NPH) models, examining first onsets of MD and AD, were used with twins from SS pairs and conditional logistic regression for OS pairs. Parent–child separations prior to age 17 were divided into death and separation from other causes.Results. The PH assumptions of constant increased risk were rejected for the impact of loss on risk for MD but not for AD. NPH models found significantly increased risk for MD after both death and separation with the risk lasting much longer for separations. For AD, the PH model found significantly increased risk after parental separation but not death. In both SS and OS twin pairs, no sex differences were seen in the impact of parental loss on risk for MD whereas the association between separation and risk for AD was significantly stronger in females than in males.Conclusion. Consistent sex differences in the association with parental loss were seen for AD but not MD. The analysis of the time-course of increased risk after loss suggests three different patterns which may reflect different relationships: parental death and MD (return to baseline within ∼12 years), separation and MD (return to baseline within ∼30 years) and separation and AD (no change in risk over time).
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Zolnikov, K. P., D. S. Kryzhevich, and A. V. Korchuganov. "Nucleation and development of plasticity in nanocrystalline BCC iron under shear loading." Izvestiya vysshikh uchebnykh zavedenii. Fizika, no. 11 (2020): 17–22. http://dx.doi.org/10.17223/00213411/63/11/17.
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The features of the nucleation and development of plasticity in nanocrystalline iron with BCC lattice under shear were studied. The mechanisms of plastic deformation playing the main role in the development of structural rearrangements during loading were revealed. It was shown that the development of plasticity can be conditionally divided into several stages. The first stage of plasticity development is associated with the formation and propagation of dislocations and twins. At the second stage, intraganular slip and intergranular sliding begin to make the main contribution to plastic deformation. These processes initiate a change in the shape of the grains. At large shear, the deformation behavior of the sample is governed by the migration of the interfaces. Not only grain boundaries migrate but also twin ones do. As a result of migration processes, the grain sizes of the nanocrystalline sample are enlarged.