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Parisi, Joel A. "The United States department of housing and urban development, office of inspector general, office of investigation an examination into why the agency should create a separate division to investigate gun and drug related violent crime in and around public and assisted housing developments /." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 2004. http://www.kutztown.edu/library/services/remote_access.asp.
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Thesis (M.P.A. )--Kutztown University of Pennsylvania, 2004Source: Masters Abstracts International, Volume: 45-06, page: 2955. Typescript. Abstract precedes thesis as 4 preliminary leaves (ii- v). Includes bibliographical references ( leaves 108-111).
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Kelley, Kevin J. "The division of household labor among Black, White and interracial couples." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 1987. http://www.kutztown.edu/library/services/remote_access.asp.
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Zhou, Miao. "Development of peptide-like library." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7232.
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Peptide libraries are important in peptide based drug discovery and investigations of biological targets. Different chemical and biological methods have been developed to screen and decode peptide libraries. mRNA display technology is a biological method that utilizes in vitro translation systems to build peptide libraries, and the screened peptides are decoded by their covalently attached oligonucleotide templates. Like other biological methods, mRNA display technology can generate peptide libraries with high fidelity and speed but the chemical repertoire is limited mostly to natural amino acids. Our research goal is to expand the chemical repertoire of mRNA display technology by using it in combination with an in vitro reconstituted translation system, and build peptides containing stabilizing chemical features such as N-methyl amino acids that would make peptides more proteolytic resistant and drug-like.
Using a streptavidin-dependent gel shift assay, the unnatural amino acids, N-methyl-L-alanine, N-methyl-L-glutamate, N-methyl-L-ornithine, L-abrine, t-butyl-L-glycine, biocytin, and sarcosine were shown to be able to incorporate successively into hexa-peptides in the mRNA display format. The peptides containing unnatural amino acids were shown to be more resistant to proteinase K proteolysis than peptides containing only the natural amino acid L-alanine. Several mRNA libraries were made in accordance with the mRNA display format. Repeated E. coli in vitro reconstituted translations of these mRNA libraries with varying translation conditions fail to yield peptides of significant lengths. However, a library of tetra-peptides was synthesized in the absence of mRNA display format. Thus, the puromycin linker required by mRNA display technology seemed to interfere with proper translations in the E. coli in vitro reconstituted translation system. Experiments showed that E. coli in vitro reconstituted translation system is slow at making full-length peptides in the context of mRNA display technology and a majority of products are prematurely terminated translation products, which could be due to slow peptidyl formation in the E. coli in vitro reconstituted translation system, or the result of undesirable interaction between the E. coli ribosome and puromycin linker that interfere with normal translation. This slow translation kinetic issue needs to be addressed with further experiments in order to successfully pursue the development of this technology.
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Leiboff, Joshua A. "How an NCAA Division II institution can utilize the World Wide Web to promote it's athletics program." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 1998. http://www.kutztown.edu/library/services/remote_access.asp.
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Thesis (M.S.)--Kutztown University of Pennsylvania, 1998.Source: Masters Abstracts International, Volume: 45-06, page: 2713. Typescript. Abstract precedes thesis as preliminary leaves [1-2]. Includes bibliographical references (leaves 37-38).
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Zhong, Sheng. "Software library for reuse-oriented program development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0030/MQ62310.pdf.
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Bieber, Ann D. "A review of the organizational structures of selected Pennsylvania community colleges as it pertains to the noncredit division." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 1989. http://www.kutztown.edu/library/services/remote_access.asp.
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Thesis (M.P.A.)--Kutztown University of Pennsylvania, 1989.Source: Masters Abstracts International, Volume: 45-06, page: 2931. Abstract precedes thesis as [3] preliminary leaves. Typescript. Includes bibliographical references (leaves 92-93).
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Wong, Jessica Karen. "Optimizing a protein-RNA aptamer gene regulatory system using an engineered peptide library." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65513.
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Thesis (M. Eng.)--Harvard-MIT Division of Health Sciences and Technology, June 2011."June 2011." Cataloged from PDF version of thesis.
Includes bibliographical references (p. 75-79).
For this project, N-terminal and C-terminal peptide library fusions were designed,bconstructed, and screened in order to improve the repression achievable with a novel gene regulatory system. This system, based on the interaction between proteins and proteinbinding RNA aptamers, takes advantage of the reversible interaction between TetR and its RNA aptamer binding partner 5-1.2 to modulate gene expression. With no tetracyclines present, TetR preferentially binds to aptamer 5-1.2 in the mRNA of a gene of interest with low nanomolar affinity and represses translation. Tetracyclines such as aTc induce a conformation change in TetR, prevent TetR binding to aptamer 5-1.2, and induce gene expression. Therefore, TetR binds aptamer 5-1.2 in an aTc-dependent manner, allowing inducible control of gene expression through the TetR-aptamer system. Initial characterization showed a regulatory range of 78% or approximately 5 fold in S. cerevisiae. The aim of this project is to improve repression levels achievable with the TetR-aptamer system by creating libraries of N-terminal and C-terminal peptide fusions to TetR and screening for increased repression in S. cerevisiae. The N-terminal and C-terminal library fusions were constructed from synthesized oligonucleotide fragments and a baseline TetR vector containing library insertions sites at both the N-terminal and C-terminal ends. The library fragments contain 20 random amino acids and a standard SSG linker peptide flanked by both single-cutting restriction enzyme sites and 40 bases of homology to the library insertion sites on the baseline TetR vector, allowing for construction by both restriction/ligation cloning in bacteria and yeast homologous recombination. Both libraries were constructed using restriction/ligation cloning after initial experiments determined optimized conditions for PCR, digest, purification, ligation, and electrocompetent bacterial transformation to achieve a maximum efficiency, fidelity, and purity. The N-terminal and C-terminal libraries produced have a combined diversity of 2.5x 105 variants. These library variants were screened using a plate-based assay with URA3 as a reporter gene. A selection with 5-fluoroorotic acid (5-FOA) was performed to identify library variants with improved repression. Since 5-FOA is a competitive inhibitor of URA3, cells that have URA3 expression cannot live on media containing 5-FOA. Preliminary experiments determined that 0.035% 5-FOA is the threshold for growth for the baseline
(cont.) TetR-aptamer system. Library variants containing 5-1.2-URA3 were grown on media containing a gradient of 5-FOA concentrations between 0.03% and 0.06% and compared to baseline TetR growth. Thirty-one library variants grew at a 5-FOA concentration greater than the baseline threshold for growth. These library hits underwent testing to further characterize their repression, inducibility, and library sequence. The 31 colony hits were streaked on discrete concentrations of 5- FOA to determine colony-specific 5-FOA thresholds and on uracil dropout media in the presence and absence of aTc to screen for preserved inducibility. Of the original 31 colonies, 25 passed both plate assays, growing on 0.045% 5-FOA and in a Tc-dependent manner on uracil dropout media. These 25 colonies were sequenced and analyzed using MEME to detect any conserved motifs. Twenty of the 25 sequenced colonies contained correct and unique libraries, 3 with N-terminal libraries and 17 with C-terminal libraries. Both the N-terminal and C-terminal library sequences had significant motifs. For the Nterminal sequences, all three contained the same 14 nucleotide motif, and 16 of the 17 Cterminal sequences also contained a 21 nucleotide motif. However, the unbiased selection for improved TetR functionality likely returned hits that use multiple mechanisms of action to enhance repression. Therefore, out of a diverse library pool containing 2.5x 105 variants, 20 unique library variants conferred increased repression on the TetR-aptamer system while maintaining inducibility in the presence of tetracycline.
by Jessica Karen Wong.
M.Eng.
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Johnson, Jimmy. "What is the process for producing a weekly magazine-format video Webcast intended to promote a Division II athletic program?" Instructions for remote access, 2009. http://www.kutztown.edu/library/services/remote_access.asp.
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Chang, Naicheng. "The impact of XML in digital library development." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445715/.
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This thesis examines the strength of Extensible Markup Language (XML) technology and explores the impact of the implementation of XML in three digital library initiatives which are used as case studies by examining in depth their digital library development. In part I, metadata issues are covered and the different kinds of metadata and metadata systems available for use in digital libraries are evaluated. Different models of storing the data and their relationship with XML are evaluated. The role of SGML in the early development of digital libraries is covered. To illustrate data manipulation, the author experiments with a digital library of images and their evaluations which use an XML-aware relational database. This part also concludes content management of both text and non-text which have used XML or may in the future move towards XML. In part II, three case studies are examined and the results of interviews done by the author when visiting them assist in a detailed evaluation of the three examples. The three digital libraries are: the Library of Congress National Digital Library Program (NDLP), the University of Michigan Digital Library Services (DLS) and the Perseus Digital Library (PDL). Each digital library is evaluated in depth taking into account the digitization processes used, the metadata systems they employ and how the metadata are created, and the delivery systems. The HTTP usage statistics of the three case studies are also analyzed. The on-going work required for the maintenance of the digital libraries, managerial aspects relating to staff management, information on users and their usage and organizational aspects are covered and evaluated. The author evaluates in what ways in each of those aspects the use of XML could benefit the digital library's development. The thesis finishes with a number of recommendations that could be taken up by digital libraries to their benefit.
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Dworaczyk, William J. "Use of Stufflebeam's CIPP Model to Assess a Change Effort in a Division of a University Library." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc277820/.
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Reorganization efforts within colleges and universities are increasingly considered as institutions look for ways to streamline operations for financial cost savings or competitive advantage. The purpose of this study was to assess a particular change effort in a university library which took place between August, 1996 and July, 1997. A team was formed to manage the change effort, and an outside consultant was hired to facilitate the process and guide the team. Stufflebeam's evaluation model was used as a conceptual framework to evaluate the entire process which included a particular change management model brought in by the consultant. The entire change effort was described by the author as a participating member of the team and assessed by gathering feedback from team members, library staff members affected by the effort, and members of the library administration.
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Tantsuyev, Andriy. "Perspectives for logistics clusters development in Russia." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77470.
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Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2012.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 63-66).
This thesis is a normative work aimed at identifying locations in Russia with high, medium and unclear potentials for logistics cluster development. As a framework this work uses four different models of logistics clusters: Major Seaport, Auxiliary Seaport, Major Inland and Auxiliary Inland logistics clusters. Conclusions are based on analysis of port connectivity, population incomes within eight hours of driving from a specific location, auto roads accessibility, economic effectiveness of local government and quality of auto roads. This paper provides guidelines for decision makers about how to set up the rail infrastructure in order to support the logistics development across different parts of Russia. Furthermore, this work suggests where future research should be amplified, especially concerning the quality of input data.
by Andriy Tantsuyev.
M.Eng.in Logistics
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Correa, Jane. "Young children's understanding of the division concept." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259886.
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Keiser, Nishla 1978. "Development of novel analytical tools for complex carbohydrates." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28525.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.Includes bibliographical references.
Complex carbohydrates such as the heparin/heparan sulfate glycosaminoglycans (HSGAGs) and the asparagine linked glycans (N-glycans) have emerged as crucial components of many human biological systems. Both classes of molecules have diverse roles in normal and pathological processes including development, cell growth, wound healing, angiogenesis, viral entry, and cancer. Taking advantage of the ability of carbohydrates to affect biological outcomes, several companies have already begun developing sugar-based structures as therapeutics for malaria and breast cancer, among others. However, the structural complexity that allows HSGAGs and N-glycans to exhibit such a wide array of activities also makes them more difficult to study than their protein and nucleotide counterparts. There are currently no effective methods for rapid synthesis of specific HSGAG or N-glycan structures, and until recently, most common analytical techniques were not useful in this field due to sensitivity constraints. Now, with advances in separation techniques and mass spectrometry, the fundamental roles of biological carbohydrates can be elucidated more efficiently. However, there is still a need for improved methodologies for studying these classes of molecules. This thesis describes the development of a novel technique for the direct isolation and sequencing of protein-binding HSGAG oligosaccharides. As a proof-of-concept, we used heparin and HSGAG-binding proteins of known specificity (fibroblast growth factor and antithrombin III), then utilized the technique to identify an oligosaccharide binder for a protein with unknown HSGAG binding specificity (endostatin). Furthermore, this technique can be readily applied to carbohydrate material from the cell surface. We have
(cont.) optimized methods for harvesting and purifying cell surface HSGAGs that are suitable for use in many experimental procedures. Taken together, these methods will allow for the rapid identification of HSGAG sequences from biologically relevant sources that bind to proteins of interest, potentially leading to new pharmaceutical targets. Not only do carbohydrates represent a huge potential drug market, they have an enormous role in the development of protein therapeutics. Since N-glycans can significantly alter the activity and half-life of proteins, it is essential to have the appropriate glycosylation for maximum effect. We therefore optimized a method for analyzing the carbohydrate component of N-glycans from mass-produced proteins, and compared the glycosylation patterns of the same protein produced in different types of bioreactors. Further, we built upon the methods for analyzing N-glycans from single proteins to obtain a complete N-glycan profile from total serum glycoproteins. Searching for patterns in these profiles may yield new information on N-glycan changes in disease states, and lead to more sensitive diagnostic testing.
by Nishla Keiser.
Ph.D.
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Manuel, Sue. "Strategic management and development of UK university library websites." Thesis, Loughborough University, 2012. https://dspace.lboro.ac.uk/2134/10958.
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This research assessed website management and development practices across the United Kingdom university library sector. As a starting point, the design and features of this group of websites was recorded against criteria drawn from the extant literature. This activity established core content and features of UK library websites as: a search box or link for searching the library catalogue, electronic resources or website; a navigation column on the left and breadcrumb trail to aid information location and website orientation; homepage design was repeated on library website sub-pages; university brand elements appeared in the banner; and a contact us link was provided for communication with library personnel. Library websites conformed to 14 of the 20 homepage usability guidelines examined indicating that web managers were taking steps to ensure that users were well served by their websites. Areas for improvement included better navigation support (sitemap/index), greater adoption of new technologies and more interactive features. Website management and development practices were established through national survey and in-depth case studies. These illustrated the adoption of a team approach to website management and development; formal website policy and strategy were not routinely created; library web personnel and their ability to build effective links with colleagues at the institution made a valuable contribution to the success of a library website; corporate services and institutional practices played an important part in library website development; library staff were actively engaged in consultations with their website audience; and a user focused approach to website development prevailed. User studies and metric data were considered in the website evaluation and development process. However, there were some issues with both data streams and interpreting metric data to inform website development. Evaluation and development activities were not always possible due to staff/time shortages, technical constraints, corporate website templates, and, to a lesser extent, lack of finance.
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Davis, Roger R. "Development of the Richard J. Brown Library information kiosk." Online version, 2002. http://www.uwstout.edu/lib/thesis/2002/2002davisr.pdf.
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Swanson, Alan D. "International human rights law and development : a human rights way to development." Thesis, University of Essex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341236.
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Eralp, Ziya Deniz. "Assessment of performance in the domain of product development." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/83789.
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Thesis (S.M. in Engineering and Management)--Massachusetts Institute of Technology, Engineering Systems Division, 2012.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 98-102).
Improvement of business performance is an enduring subject of research across a diverse set of disciplines such as accounting, operations management, marketing, finance, economics and even psychology and sociology. In any discipline the ability to create self-awareness, a capacity to evaluate and compare their own behavior to internal standards and values, is a pre-requisite of improvement. In an organization, self-awareness is created with assessments. The results of assessments can help the organization to adapt to changing market conditions by defining more valuable objectives to direct its new businesses as well as to restructure its operations for eliminating deficiencies that limit its abilities to achieve its business goals at lower costs. For an organization with core businesses in product development (PD), assessment of PD is an essential element of all business improvement initiatives. However, in order to perform a focused PD assessment, the analysis needs to be structured with a systematic top-down approach which relates the findings of evaluations starting from high-level business goals down to the metrics for the most detailed operational activities. In this thesis, an existing Product Development Self-Assessment tool is integrated into this context, and implementation of a top-down assessment is presented using a three-step process. Other supplemental tools and methods are also incorporated into the discussion of the implementation framework such as; Goal-Question-Metric (GQM) and IDEFO function modeling methodologies. With the use of illustrative examples, the application steps of the framework and the use of supplemental methods are presented.
by Ziya Deniz Eralp.
S.M.in Engineering and Management
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Zelkha, Sassan. "Benchmarking of a medical device company's product development process." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/79426.
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Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, 2012.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (p. 88-90).
In todays' global economy, having a lean operation is no longer considered a competitive edge; rather has become the new necessity and norm [15]. The new source of this competitive edge is innovation [15]. What sets an organization apart from its competitors is the ability to develop products that constantly meet customers' demands. An organization must have a New Product Development Process (NPDP) that enhances, expedites and fosters development of innovative products on consistent basis in order to tie innovation to market success. Many organizations have a difficult time determining whether or not the NPDP they are using is adequate because there are no standard methods or processes that organization can use to assess their NPDP [16]. In order to assist a specific medical device organization to assess its NPDP, a partnership with Performance Measure Group (PMG) was established. PMG is a leader in benchmarking and performance measurement. This thesis gives insight into the various new product development and benchmarking processes that are in practice today. It also explores the challenges and benefits associated with conducting benchmarking. Finally, this thesis reveals some of the challenges that this particular medical device company confronts with their NPDP.
by Sassan Zelkha.
S.M.
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Zamora, Torres Carlos Xavier. "Engineering work breakdown and assignment for global product development." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79533.
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Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, 2013.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 107-110).
Companies are always looking for ways to reduce their costs, cost reductions which allow companies to increase their overall profits. There are various cost reductions strategies, such as: change materials and/or design of the products, change suppliers, and offshore engineering. This last strategy, offshore engineering, is a common practice in today's global industries. This thesis applies the cost-reduction strategy of offshore engineering to the automotive industry. Specifically, this thesis presents an analysis of the Seat Subsystem, which assists the corporation in selecting which components of the subsystem are optimal to be offshored. Based on product architecture design structure matrices, this analysis identifies clusters of components within the Seat Subsystem which are highly interrelated. After adding three variables: experience needed to develop each of the components, current experience of the offshore office, and supplier location of these components, a proposal of which components should be offshored is presented. Further, in this thesis a Process/Organization DSM is used to identify when in the seat development process the Seat Engineers have closer relations with other departments within the organization. The results of this Process/Organization DSM will assist the company in creating travel plans for the engineers. After establishing which components of the seat should be offshored, an additional analysis is presented which assists the organization in determining where to offshore these components. This analysis is based on three frameworks: CAGE, ADDING, and Porter's and virtual diamond. A summary of the results of this analysis presents a quantitative evaluation of three offshoring options: China, India, and Mexico. In addition, in this thesis an analysis is presented to determine how the Seat Organization Architecture needs to be adapted in order to support the Offshore Strategy. This organization transformation is based on three methodologies: Enterprise Architecture Sequence Model, 4P's of Strategy, and Seven Strategy Questions. At the end of this thesis, a six-step process is presented to assist other organizations when an offshore strategy is needed to breakdown the development of a product or system and determine where to offshore each of the components.
by Carlos Xavier Zamora Torres.
S.M.
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Castro, João Nuno Lopes. "Individuals in product development : interactions with teams and products." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62758.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Engineering Systems Division, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 107-116).
This dissertation focuses on how individuals involved in complex product development operate and interact with other people in the project and how they perceive and modify the product. Complex product development requires the collaboration of multiple individuals who are specialists in different disciplines. One of the challenges with the execution of design and development projects is coordinating the contributions of each individual to guarantee an aligned, seamless fit. I review a selection of the literature on team frameworks, coordination methods and empirical product development studies which address teams, individuals and product architectures and structures. I then conduct two studies. One focuses on individual to individual communication requirement stability and the other on individual interaction with product structure over the development period. In the first, I examine how the most important communication channels between individuals in multifunctional teams compare across thirteen different projects. In this study I found a direct correlation between functionally similar projects and their network of important communication links between individuals. This indicates that when faced with a problem of similar nature the profile of connections between individuals - which ones are more or less important - will also be similar. In the second, I study how individuals interact with the structure of a product in four software development projects. I found that most individual work is localized and consists of internal improvement work. When work is done that requires simultaneous modifications of several components, I found that the associations made between components does not follow the existing structural dependencies as indicated by the function calls between components. This behavior is consistent throughout the development of the projects and is not dependent on the design state of the product. The associations made between components are also not a good indicator of future structural dependencies. These observations do not follow the indications from previous work on team interactions and product structure, revealing that individuals make associations beyond those suggested by just the structural connections. It was also observed that individuals are able to identify and work on the most important components in a product and that work is conducted on components irrespective of their age in the system. Finally, a real-time observation of project execution method is proposed based on the several analysis steps developed within this thesis. The use of this method can be advantageous for practitioners to verify the progress of project and control deviations from plan. This thesis contributes directly to the stream of research of coordination in product development and contributes to the practice with new methods to help those involved in large-scale complex product development filter the extensive work done by many individuals and find areas of possible intervention.
by João Nuno Lopes Castro.
Ph.D.
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Rupani, Sidharth. "Standardization of product development processes in multi-project organizations." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/91082.
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Thesis: Ph. D., Massachusetts Institute of Technology, Engineering Systems Division, 2011.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 120-126).
An important question for a large company with multiple product development projects is how standard or varied the sets of activities it uses to conceive, design, and commercialize products should be across the organization. To help address this question, this project is comprised of three research activities to improve understanding of the influence of standardization of product development processes on performance. Previous research indicates that process standardization has many positive (improved efficiency, knowledge transfer, decision making and resource allocation) and negative (reduced creativity, innovation, adaptation and learning, employee satisfaction) performance effects. Even focusing on specific performance outcomes, the influence of process standardization is contested. The first phase was a set of theory-building case studies at five large companies that develop electromechanical assembled products. One important lesson from the case studies was that to appropriately evaluate the impact of standardization on performance it is essential to disaggregate the process into its individual 'dimensions' (activities, deliverables, tools, etc.) because standardization on different dimensions of the process impacts performance outcomes quite differently. Another lesson was that companies differ in their process standardization approach because of differences in their portfolio characteristics and in their strategic priorities across performance outcomes. Based on the importance of focusing on individual process dimensions, a broad and systematic literature study was conducted with the aim of better capturing the current state of knowledge. This literature study resulted in a framework to characterize the problem space, a comprehensive set of relevant project characteristics, process dimensions, and performance outcomes and a summary of the established links, contested links, and unexplored links between these elements. Focusing on one set of contested links from the literature, the final research activity was a detailed empirical study at one company. The goal was to study the effect of variation in project-level product development processes, operating under the guidance of an established process standard, on project performance. The purpose-assembled data set includes measures of project characteristics, process dimensions, and project performance outcomes for 15 projects. Statistical analyses were performed to examine the relationships between process variation and project performance outcomes. Where possible, the statistical analyses were supported and enriched with available qualitative data. The results indicated that, at this company, process variation in the form of both customization and deviation was associated with negative net outcomes. Customization (in the form of combining project reviews) was associated with reduced development time and development cost, but also with lower quality, likely because of reduced testing. On net, in dollar terms, combining reviews was associated with negative outcomes. Specific deviations (in the form of waived deliverables) were also associated with negative performance consequences. Results also supported the lessons from Phase 1. Variation on different process dimensions was associated with different performance outcomes. Disaggregation was important, with many insights lost when deviations were aggregated. This project enhanced our understanding of the performance impacts of product development process standardization. The case studies highlighted the importance of disaggregating to individual process dimensions to correctly evaluate the effects of standardization. The systematic literature study resulted in a framework for organizational decision making about process standardization and a summary of the current state of knowledge - elements, established links, contested links, and unexplored links. The detailed empirical study at one company examined one set of contested links - between process standardization and project performance - and found that process variation in the form of both customization and deviation was associated with net negative effects on project performance.
by Sidharth Rupani.
Ph. D.
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Quesada, Hernandez Elena. "The Role of Cell Division Orientation during Zebrafish Early Development." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-64735.
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The development of multicellular organisms is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape.
However, the actual contribution of stereotypical cell division orientation (SDO) to tissue morphogenesis is unclear. In zebrafish, cell divisions with stereotypical orientation have been implicated in both body axis elongation and neural rod formation, although there is little direct evidence for a critical function of SDO in either of these processes.
Making use of extended time-lapse, multi-photon microscopy and a careful three-dimensional analysis of cell division orientation, we show that SDO is required for neural rod midline formation during neurulation, but dispensable for body axis elongation during gastrulation. Our data indicate that SDO during both gastrulation and neurulation is dependent on the non-canonical Wnt receptor Frizzled 7 (Fz7), and that interfering with cell division orientation leads to severe defects in neural rod midline formation, but not body axis elongation.
These findings suggest a novel function for Fz7 controlled cell division orientation in neural rod midline formation during neurulation. They also shed new light on the field of cell division orientation by uncoupling it from tissue elongation.
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Kessler, Sharon Ann. "Molecular mechanisms controlling cell division and differentiation during maize development /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.
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Chu, Calvin School of Biomedical Engineering UNSW. "Development of a semi-automatic method for cellular migration and division analysis." Awarded by:University of New South Wales. School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/20543.
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Binary image processing algorithms have been implemented in this study to create a background subtraction mask for the segmentation of cellular time lapse images. The complexity in the development of the background subtraction mask stems from the inherent difficulties in contrast resolution at the cellular boundaries. Coupling the background subtraction mask with the path reconstruction method via superposition of overlapping binary segmented objects in sequential time lapse images produces a semi-automatic method for cellular tracking. In addition to the traditional center of mass or centroid approximation, a novel quasi-center of mass (QCM) derived from the local maxima of the distance transformation (DT) has also been proposed in this study. Furthermore, image isolation and separation between spreading/motile and mitotic cells allows the extraction of both migratory and divisional cellular information. DT application to isolated mitotic cells permits the ability to identify distinct morphologic phases of cellular division. Application of standard bivariate statistics allows the characterization of cellular migration and growth. Determination of Hotelling???s confidence ellipse from cellular trajectory data elucidates the biased or unbiased migration of cellular populations. We investigated whether it was possible to describe the trajectory as a simple binomial process, where trajectory directions are classified into a sequence of (8) discrete states. A significant proportion of trajectories did not follow the binomial model. Additionally, a preliminary relationship between the image background area, approximate number of counted cells in an image frame, and imaging time is proposed from the segmentation of confluent monolayer cellular cultures.
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Camp, James (James Patrick) 1977. "Development of simple 3D-printed scaffolds for liver tissue engineering." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/16864.
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Thesis (S.M. in Bioengineering)--Massachusetts Institute of Technology, Biological Engineering Division, 2002.Includes bibliographical references (leaves 51-52).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
One solution to the increasing need for liver transplants is to grow implantable liver tissue in the lab. A tissue-engineered liver for transplantation will require complex structures to support cell differentiation and integration with surrounding vasculature. Recent developments in 3D-printing (3DP™) technology allow the construction of such geometrically complex scaffolds out of biodegradable polymers. These artificial tissues should maintain healthy, functional hepatocytes in proper contact with supporting cell types in the context of proper flow cues. This project comprises three major efforts. First, the design and development of a 3D-printed scaffold, constructed of a porous biodegradable polymer matrix, for flow bioreactor culture. Second, the development of protocols for the production, preparation, and flow support of these scaffolds. And third, the employment of standard cell culture methodologies to test the ability of these scaffolds to support liver tissue cultures. Initial cell culture experiments showed similar rates of albumin production in the polymer disk scaffolds compared to cells in silicon-chip scaffolds under appropriately scaled flow conditions, indicating that the polymer scaffolds maintain functioning liver tissue. Further, histology sections of liver tissue grown on these polymer scaffolds show organization of cells into structures reminiscent of in vivo liver. The results of this study show that 3D-printed porous polymer scaffolds have great potential for use as biodegradable tissue culture support devices. It is believed that, combined with printing technologies now under development, the technologies developed in this thesis will help facilitate the construction of an implantable tissue engineered liver.
by James Camp.
S.M.in Bioengineering
26
Kashyap, Pankaj Kumar. "Goal setting for improvement in product development performance of organizations." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83792.
Full textAbstract:
Thesis (S.M. in Engineering and Management)--Massachusetts Institute of Technology, Engineering Systems Division, February 2013.Cataloged from PDF version of thesis. "Sep 2012."
Includes bibliographical references (pages 107-109).
Companies have been constantly trying for ways and means to improve R&D performance as it is one of the most important competitive advantage tools of an organization. Literature review on R&D performance improvement suggests that, lot of focus is on measuring R&D performance and on specific problem solving approaches like six sigma and lean. Frameworks like capability maturity model integration (CMMI) and product development self-assessment tool (PDSAT) provide holistic performance assessment, but fall short on providing clear guidance for performance improvement interventions. Goal setting theory, a proven theory that is widely applied in individual performance improvement has got limited attention in R&D performance improvement approaches and frameworks. Practitioners in the industry point to the need for goal setting in R&D and identify that as a gap in current performance improvement methodologies. This thesis attempts to fill this gap by proposing DEAL framework, a practical approach for defining future goals in R&D performance improvement efforts.
by Pankaj Kumar Kashyap.
S.M.in Engineering and Management
27
Townsend, Seth A. (Seth Alan). "Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45948.
Full textAbstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.Includes bibliographical references (p. 224-236).
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with diagnostics and treatments that are ineffective at stopping the progression. This thesis examines new ways of both diagnosing and treating ALS, including 1) a gadolinium tetanus toxin C fragment (Gd-TTC) biomarker for axonal retrograde transport, 2) TTC-conjugated biodegradable nanoparticles, and 3) poly(glycerol-co-sebacate) acrylate (PGSA) and 3D scaffolds for human embryonic stem cell (hESC) and neuronal encapsulation.A Gd-TTC conjugate was developed and characterized that was shown to be highly visible under MRI and preserved the functionality of the native TTC protein in vitro. Live animal MRI imaging and immuno fluorescent staining of the spinal cord showed that the conjugate was transported to the central nervous system (CNS) and localized in motor neurons. H&E staining and biodistribution studies showed that GdTTC was well tolerated and bio available. Quantification of MRI and staining images showed that Gd-TTC was retrograde transported and that that this rate decreased during the disease progression of ALS in a transgenic mouse model, suggesting that Gd-TTC could be used as a biomarker for neurodegenerative diseases.TTC-conjugated nanoparticles were developed by synthesizing PLGA-PEG-biotin and using biotin binding proteins (avidin, streptavidin, and neutravidin) to specifically conjugate TTC to the nanoparticle surface. TTC nanoparticles were shown to selectively target neurons and not other cell types in vitro.
(cont.) Subsequent in vivo experiments showed that nanoparticles were well tolerated and that TTC was co-localized with neurons unilaterally, suggesting that TTC-conjugated nanoparticles may be a useful drug delivery system. Porous PGSA scaffolds were prepared and characterized by porosity, swelling, mass loss, toxicity and mechanical properties, and subsequently used to encapsulated hESC and neuroblastoma cells in vitro. Neuroblastoma cells proliferated and formed matrix fibrils, and fluorescent staining of undifferentiated hESCs showed the presence of all three germ layers. In vivo experiments showed that porous PGSA scaffolds were well-tolerated and promoted vascular ingrowths.
by Seth A. Townsend.
Ph.D.
28
Makumbe, Pedzisayi O. "System development technical interactions and innovation : a network-based investigation." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34552.
Full textAbstract:
Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, 2006.Includes bibliographical references (leaves 70-77).
The development of complex engineering systems such as aircraft engines involves many cross functional teams that are usually geographically distributed. These teams interact in several ways but one of the most important set of interactions during the product development phase is the flow of technical information which is largely used for coordination and problem solving. For analytical purposes, these technical information flows can be represented as a directed network. This thesis develops a context and a research design that can help one investigate the impact of the resultant network structure on innovation in complex engineering systems. The broad context can be divided into two: theoretical and real world contexts. The theoretical context is developed by reviewing literature at the intersection of networks and innovation, and the real world context is typified by a modular enterprise developing a complex engineering system. Within this broad context, the research area of interest is framed by a set of hypotheses that lead to precise innovation measures and characterizations. The research design is motivated by the context and intended theoretical contributions. It consists of two major sections.
(cont.) The first section discusses and critiques methodologies for constructing networks and proposes a methodology more suited to this engineering systems development context. The second section describes a two-stage model whose variables include network structural properties such as structural holes, nodal degree, tie strength, and innovation output. It also describes a methodology for investigating the relationship between network density and the innovation development subprocess. Finally, the context and research design are tied together to create an instantiation of the measurement and characterization of innovation in complex engineering systems development. The characterization considers product innovation as radical, architectural, modular or incremental, and process innovation as organizational / coordination-based or technical. The measures of innovation include granted patents, implemented employee suggestions, product literature based innovation counts and results from structured interviews with the two leaders from each node in the network.
by Pedzisayi O. Makumbe.
S.M.
29
Kurapov, Herman Alex. "Analysis of supplier involvement in new product development and launch." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/35614.
Full textAbstract:
Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2006.Includes bibliographical references (leaves 78-91).
New or innovative products are growing in importance both in numbers and revenues, putting an extra stress on most current supply chains - defined conceptually as a buyer with a network of suppliers - as those were originally designed for efficiency purposes and existing products. While new products due to their characteristics, such as short life cycle, demand variability, and high investment risk, require responsive, flexible, adaptable supply chains and relevant practices. Those practices need to be properly tailored for specific different types of new products, perceived as a continuum of newness and change. This thesis examines supply chain management and supplier management practices for new products across different industries. This study has been conducted within the MIT Supply Chain 2020 Initiative using the academic and business literature research and an online survey as the methodology, and new product analytical framework as the study deliverable.
(cont.) The results of this study demonstrate that though there is a pronounced tendency to use suppliers more extensively to improve new product performance and general competitiveness, companies approach the supplier new product involvement very differently - depending on the type of new product in question and the specific mix of its key activity categories, which were identified in this study and corresponding framework as Flexibility, Control, Technology and Cost Focus.
by Herman Alex Kurapov.
M.Eng.in Logistics
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Eide, Jan. "Rethinking CCS - strategies for technology development in times of uncertainty." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/81119.
Full textAbstract:
Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, 2013.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 115-119).
Concerns over climate change and a reliance on CO₂-emitting fossil fuels for a majority of the world's energy supply have motivated the development of carbon dioxide capture and storage (CCS). However, CCS is not yet commercially available, and key technical roadblocks remain. However, the external circumstances for developing the technology, such as weak climate policy and tight public finances, have changed dramatically over the past four years and current RD&D roadmaps are poorly adapted to the new realities. In order to rethink U.S. CCS policy, and to provide a realistic roadmap for technology development, this thesis provides an overview of the key technical roadblocks, an analysis of the impact of the new realities on CCS investments, and a novel method for finding the optimal way of allocating scarce public resources to CCS RD&D. The U.S. has responded to the changing political context in two notable ways. First, Enhanced Oil Recovery (EOR) has received increased attention due to the positive value that EOR storage puts on CO₂. Second, the EPA has proposed a 1000 lbs CO₂/MWh emission standard that would require new coal plants to install CCS. Using a stochastic generation expansion model, this thesis concludes that low natural gas prices make fuel switching rather than CCS investment the most likely compliance method. Moreover, should these standards be gradually tightened, CCS will likely be deployed on natural gas plants before coal plants. More generally, the model highlights the importance of considering uncertainty when analyzing CCS investments, and results differ notably depending on whether probability distributions over parameters are considered or not. With limited funds available for technology development there is a striking need to ensure that limited resources are allocated strategically. Whereas designing optimal technology RD&D portfolios has traditionally been dealt with qualitatively, this thesis develops a quantitative model for choosing optimal portfolios of demonstration projects. The strength of new model is how it incorporates the different uncertainties associated with CCS, allowing decision makers to observe how different underlying assumptions affect project choices. Based on my analyses, I make six recommendations for CCS technology development in times of uncertainty, many of which are major departures from current U.S. CCS policy. First, the U.S. should focus more on pilot-scale development of novel capture concepts promising to significantly reduce cost. Second, if gradually tightening emission standards is to be the primary mechanism to reduce power sector CO2 emissions, then the U.S. should also demonstrate CCS on natural gas plants. Third, granting a limited number of coal plants a higher CO₂ emission standard could help bring CCS plants online in challenging times. Fourth, relying almost exclusively on projects with EOR storage is unlikely to be a sound long-term policy. Because of the significant variability across geologic storage reservoirs, at least some demonstration projects must focus on CO₂ storage in saline formations. Finally, with tightening public finances it becomes increasingly important to coordinate demonstration efforts globally to avoid unproductive overlap.
by Jan Eide.
S.M.in Technology and Policy
31
Lyons, Reneé C. "Education Resource Guide: Part III Annexation and Division – Our White House, Looking In, Looking Out." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2398.
Full textAbstract:
This education resource guide is designed to augment the content included in Part III of the NCBLA’s anthology Our White House: Looking In, Looking Out. Included on these pages are engaging activities and discussion questions regarding some of the articles and stories in Part III of Our White House.
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Chang, Durk Hyun. "Knowledge, culture, and identity : American influence on the development of library and information science in South Korea since 1945 /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
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Muchie, Mammo. "Capitalist technology and socialist development." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382455.
Full textAbstract:
This thesis is essentially about the theory of the transition to socialism and aims at comprehending the Soviet experience of attempting to re-mould the relations of production and the forces of production mainly at the level of Soviet labour processes. The main finding is that the Soviet Union was rich in debate in the 20s but short in actually pioneering new labour processes in the years of construction and accelerated industrialization. As a by-product of this larger project, the thesis has begun to demarcate the division of labour from technology by constructing models on the basis of their shared characteristics of efficiency, output, cost, control and welfare. It is argued- that an attempt to 'abolish' the fragmentation of tasks arising from the technical . division of labour would require a redirection of the physical organization of technology itself. The thesis emphasizes the importance not only the re-arranging of macro-societal-level social relations but also micro production unit level changes. The socialist project ought to include simultaneous interventions at the micro and macro levels of reality. It is suggested that despotic control at both the society and production-unit levels would hardly expand the emancipatory possibilities for labour. Nor democratization at one or the other level alone whilst keeping despotic control will do. Only simultaneous democratizations at the enterprise and society levels will make the socialist development attractive. The thesis concludes by stressing the need to reinstate democracy in relation to the organization of the labour process pointing out the responsibility of the Gorbachov leadership in relation to the democratization of Soviet society and enterprises.
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Tobias, Irene S. (Irene Sophie). "Design and in vitro development of resorbable urologic drug delivery device." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44882.
Full textAbstract:
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.Includes bibliographical references (leaves 57-62).
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous maintenance of plasma and tissue drug levels and the potential for reduced side effects or toxicity. Urology has emerged as a unique field in which minimally invasive implantation techniques are available and such devices could provide improved beneficial therapies over conventional treatments. Urological indications for which localized drug therapy is already being advocated and investigated are highly suitable for treatment with implantable controlled release devices. This thesis describes the in vitro performance evaluation of an implantable, bio-resorbable device that can provide localized drug therapy of ciprofloxacin (CIP) to the seminal vesicle and nearby prostate gland for treatment of chronic prostatitis (CP). The device functions as an elementary osmotic pump (EOP) to release CIP for a period of 2-3 weeks after implantation in the seminal vesicle (SV) through transrectal needle injection or cystoscopic methods. The device is composed of an elastomeric, resorbable polymer cast in a tubular geometry with solid drug powder packed into its core and a micromachined release orifice drilled through its wall. Drug release experiments were performed to determine the effective release rate from a single orifice and the range of orifice size in which osmotic-controlled zero-order release was the dominant mechanism of drug delivery from the device. Device stability and function in an alkaline environment of similar pH to that of the SVs and infected prostate gland was also assessed in vitro. The device was found to function well in both de-ionized water and NaOH pH-8 solution with a sustained zero-order release rate of 2.47 ± 0.29 jtg/hr when fabricated with an orifice of diameter 100-150pm.
by Irene S. Tobias.
M.Eng.
35
Davidz, Heidi L. "Enabling systems thinking to accelerate the development of senior systems engineers." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34200.
Full textAbstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Engineering Systems Division, 2006.Includes bibliographical references (p. 210-213).
As engineering systems become more complex, the roles involved in developing and managing such systems also become more complex. Thus, there is increasing interest in educating and training engineering professionals to think more systemically. In particular, there is an increasing need to accelerate the development of senior systems engineers. As new educational degree programs in systems rapidly emerge and as companies scurry to establish systems training programs to meet this need, fundamental questions still remain about how systems thinking develops in engineers. Increased understanding of the mechanisms that develop systems thinking will enable effective and efficient development of senior systems professionals. After reviewing related literature, an exploratory and inductive study was designed to gather data on enablers, barriers, and precursors to systems thinking development in engineers. In a field study conducted primarily in the United States aerospace sector, 205 interviews were conducted in 10 host companies. Senior systems engineers were studied to better understand how they developed systems thinking, and information was collected on company procedures for developing systems engineers. Using interview and survey data, comparisons were made of two control groups and senior systems engineers.
(cont.) Proven stellar systems thinkers were also interviewed. To summarize the results, even though systems thinking definitions diverge, there is consensus on primary mechanisms that enable or obstruct systems thinking development in engineers. In order to reconcile the divergent definitions observed, a systems thinking framework, definition, and accompanying conceptual illustration are given. The data show that the primary mechanisms that enable systems thinking development include experiential learning, specific individual characteristics, and a supporting environment. This document defines the research space on this topic and suggests applications for the results. Better understanding of systems thinking development provides a foundation for educational interventions and employee development in systems thinking for engineering professionals across industry, government, and academia.
by Heidi Leoti Davidz.
Ph.D.
36
Åström, Fredrik. "The social and intellectual development of library and information science." Doctoral thesis, Umeå University, Sociology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-943.
Full textAbstract:
The background of the project is partly found in a long tradition within library and information science (LIS) of meta-analyses on the field, partly in a science studies discussion on research fields and their contextual relation to wider academia, fields of professional
practices and professionalization processes. The general purpose of the project is to analyze the social and intellectual development and organization of LIS; and to investigate the impact of the close relation to the practice field, as well as the relation to the academic world in general. Based on the general purpose of the project and results and interpretations of the four articles attached to the thesis, three questions were stated for discussion in the thesis proper, concerning: the effects of a dual origin and LIS as a discipline, a field of research and a field of practice, the purpose of meta-studies and implications in terms of identity and perception of LIS; and competition and cooperation with other fields of research. Because of the heterogeneous nature of LIS, a variety of methods and materials was used in the different articles; and methodological issues on limits and bias in bibliographic databases – and the implications on the perception of research areas with varying publication and citation behaviour – were discussed. The analyses were performed against a theoretical framework, providing key organizational characteristics of scientific fields, relating to social, intellectual and contextual aspects, in combination with theories on scientific and disciplinary development, professionalization and interdisciplinarity; but also, for analytical contrast: alternate theories on the development of the sciences since 1945. LIS shows two distinct paths of development: research areas developing out of other fields of research; and a disciplinary development originating out of the field of practice and institutions for educating practitioners. Analyzing meta-studies of LIS, the picture of a field with a vague identity and a diverse self-understanding, even in terms of core characteristics, emerges. The relation to the wider academic community is characterized by diffuse boundaries towards, and competition from, other fields of research. In general, LIS is a fragmented field with a multitude of wildly varying research areas; and with large variations in terms of organizational setting; which together with a vague identity and diffuse boundaries, as well as the close connections to the field of practice, might contribute towards explaining problems LIS have been experiencing, establishing itself in academia. However, there are also signs towards an integration of a number of LIS research areas, as well as an increase in interdisciplinary cooperation, contradicting theories suggesting a further fragmentation; and supporting ideas on the sciences developing towards e.g. interdisciplinarity and applicability of results.
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Celik, Makbule Filiz. "Development Of A Library For Automated Verification Of Uml Models." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/2/12607256/index.pdf.
Full textAbstract:
Software designs are mostly modeled as Unified Modeling Language (UML) diagrams when object oriented software development is concerned. Some popular topics in the industry such as Model Driven Development, generating test cases automatically in the early phases of software development, automated generation of code from design model etc. use the benefits of UML designs. All of these topics have something in common which is the need for accuracy against the meta-model not to face problems in the latter phases of the development process. Support on the full checking of the design models is necessary for the detection of design inconsistencies.
This thesis presents an approach for automated verification of UML design models and explains the implementation of the library called UMLChecker.
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Åström, Fredrik. "The social and intellectual development of library and information science /." Umeå : Department of Sociology, Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-943.
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De, Dios Bettina G. "Development of an object library for a design support system." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03242009-040459/.
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Leung, Wai-shing Raymond. "The development of a computerized library in a primary school." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B40039845.
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Leung, Wai-shing Raymond, and 梁偉城. "The development of a computerized library in a primary school." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B40039845.
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Liu, Tao. "Development Of Cyclic Peptidyl Ligands Through A Combinatorial Library Approach." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306865559.
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Jain, Saurabh. "Development of multi-element fibres for applications in space-division multiplexing." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/391292/.
Full textAbstract:
This thesis presents a novel multi-element fibre (MEF) technology for implementing space-division multiplexing (SDM) in optical fibres. MEF comprises multiple fibre-elements that are drawn and coated together using a common polymer coating. In MEF, the fibre-elements are compatible with current technology i. e. the fibre-elements can be directly fusion spliced to standard single mode pigtail fibre. Thus, a smooth upgrade from WDM based systems to SDM system is possible. In this work, MEF technology has been implemented for both, passive SDM fibres and SDM amplifiers. Erbium-doped Core-pump MEF amplifiers have been demonstrated exhibiting similar gain and noise figure performance to conventional Er-doped fibre amplifier while maintaining ultralow crosstalk levels. In addition, an Erbium/Ytterbium-doped cladding-pumped MEF amplifier has been developed, and a novel technique to achieve a broadband gain has been demonstrated which could cover wavelength region of 1536nm-1615nm using a single multimode pump. Furthermore, MEF technology has been combined with mode-division multiplexing to show that higher spatial multiplicity could be achieved by implementing the MEF with other SDM technologies. In passive MEFs, the fabricated fibres have been characterised for their loss and transmission properties, showing low loss and error-free transmission. Also, the MEFs are proof-tested showing high strength. The compatibility of MEF fibres have been tested in a concatenated SDM system demonstrating their flexibility in the telecom network.
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Surineni, Shravan Kumar. "Venture Capital and private equity in India : systems analysis and development framework." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/83801.
Full textAbstract:
Thesis (S.M. in Engineering and Management)--Massachusetts Institute of Technology, Engineering Systems Division, 2012.Cataloged from PDF version of thesis. "June 2012."
Includes bibliographical references.
Venture Capital (VC) has been an important driver of innovation, entrepreneurship and economic growth in the U.S. and around the world for the past few decades. The astounding success of Venture Capital prompted various countries' attempts to emulate the U.S. model and create an indigenous venture capital industry. Several attempts are being pursued to emulate this success and create an indigenous Venture Capital industry in India. This thesis examines efforts to create a Venture Capital and Private Equity industry in India and the various factors that influence this process.
by Shravan K. Surineni.
S.M.in Engineering and Management
45
Song, Jaemin. "The road to the successful clean development mechanism : lessons from the past." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62763.
Full textAbstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Engineering Systems Division, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references.
The Clean Development Mechanism (CDM) has evolved at a surprising speed since 2003 and is considered to have made positive contributions to the development of greenhouse-gas-reducing projects in developing countries. Taking into account its historical significance as the first effort of its kind and its current success, a thorough evaluation of its system and its effectiveness is of critical importance. Against this backdrop, this study closely investigates each stage of the CDM project cycle from development and registration of projects to issuance of certified emission reductions and identifies influential factors for the successful CDM implementation. For the analysis, we performed an extensive quantitative analysis augmented by a descriptive study, based on information of approximately 5000 CDM project. Our findings suggest that the development of CDM projects is stimulated by favorable economic, social and technical environments in host countries as well as supportive CDM administration. This explains why projects are currently concentrated in certain countries such as China and India. Once projects are developed and submitted for validation, the success of the CDM projects at the next stages of project cycle related to registration and Certified Emission Reduction (CER) issuance is influenced by their types and a choice of Designated Operational Entities and project consultants. In particular, significant difference in registration success exists across project types, which calls for special attention of both the CDM authority and project participants to projects with high risks like energy efficiency, fossil fuel switch and biomass projects. Lastly, we found that performance of projects is affected by very project-specific conditions. For many of the most poorly performing projects, failure is attributable to technical and operational problems at the initial stage of project implementation, which highlights the importance of well-prepared PDDs. Based on the findings, the thesis concludes with policy recommendations to enhance the capacities and improve the performance of the major players under the CDM.
by Jaemin Song.
Ph.D.
46
Kwak, Eugene. "Innovation in the design and development of a commercial flight termination system." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83795.
Full textAbstract:
Thesis (S.M. in Engineering and Management)--Massachusetts Institute of Technology, Engineering Systems Division, June 2013.Cataloged from PDF version of thesis. "December 2012."
Includes bibliographical references (page 89).
With the ramp up of commercial spaceflight over the last decade with the assistance of the US Government and NASA, commercial spaceflight companies such as Space Exploration Technologies (SpaceX) and Orbital Sciences have taken significant strides in reducing the overall cost of space travel. The overall cost per launch goes far beyond the actual cost of the materials and labor associated with each launch vehicle, and must include all the political, environmental and social costs, which often amount to more than the actual cost of the vehicle itself. The main focus of my thesis is the Flight Termination System (FTS) which is the system used to terminate the flight of the launch vehicle in the event the vehicle veers off course or experiences any anomalies, which would impede its mission and cause a threat to human assets. Because of my work as the lead engineer of the FTS system at SpaceX, this thesis will mainly cover the system used at SpaceX. The FTS system is unique in that the approval of the system is as political and social as it is technical. Systems engineering is applied throughout the process of architecting, designing, testing, and manufacturing, where all stakeholders have a part in the success of each step of the product design. The key to the success of SpaceX lies in innovation, and as this thesis outlines, the FTS system has many innovative products and processes in place, including the establishment of many key relationships with stakeholders.
by Eugene Kwak.
S.M.in Engineering and Management
47
Moreno, Jorge (Jorge Alejandro Moreno de la Carrera). "Sociotechnical complexities associated with the development of Building Integrated Photovoltaic fac̦ade systems." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/79527.
Full textAbstract:
Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, February 2013."December 2012." Page 112 blank. Cataloged from PDF version of thesis.
Includes bibliographical references (p. 101-111).
Significant opportunities to improve the energy use in buildings open remarkable possibilities for innovation over the next two decades. Particularly in the United States, 41% of primary energy consumption in 2010 went into buildings. This work has applied a broad perspective that combines management, technology, and social sciences to analyze the development and integration challenges of emerging Building Integrated Photovoltaic (BIPV) systems that would likely be integrated into building fac̦ades as part of a portfolio of alternatives that might contribute to the development of zero-energy buildings. The analysis contributes to identify some sociotechnical complexities associated with the development of BIPV systems. In addition, it characterizes different products' architectures based on their technical performance, technical complexity, perceived complexity, and exposure to subjective judgment. It shows that the resolution of the friction between the aesthetic and the electricity generation function is one of the early-stage design decisions that may have significant influence on the adoption of the system.
by Jorge Moreno.
S.M.
48
Haddad, Marc George. "Knowledge integration for problem solving in the development of complex aerospace systems." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43853.
Full textAbstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Engineering Systems Division, 2008.Includes bibliographical references (p. 238-248).
The development of complex products requires widespread knowledge interactions among a significant number of individuals and teams designing numerous interrelated components. Increasing product complexity typically leads to a corresponding increase in the types and sources of knowledge that need to be tapped during development, and a common strategy for managing product complexity is to outsource parts and components to external suppliers. As a result, the knowledge required for development is increasingly specialized and distributed across multiple boundaries spanning large-scale organizational networks, thus requiring the subsequent integration of this knowledge in order to accomplish the development task. A framework for knowledge integration in the development of complex systems in a large-scale organizational context is proposed in this thesis using an extensive review of the pertinent literature. The framework consists of the main channels, strategies, practices and mechanisms most commonly used to transfer, share and apply knowledge in the course of complex technical problem solving. The framework is progressively refined using empirical data collected through several rounds of interviews and a questionnaire instrument administered across three major aircraft programs in the defense aerospace industry. We find that knowledge integration in routine problem solving situations is most efficiently and effectively accomplished through extensive transfer and sharing of codified information using formal mechanisms such as information systems, while knowledge integration for major non-routine troubleshooting events requires extensive integration of individual expertise and know-how through both formal and informal advice sharing as well as direct assistance across internal and external organizational boundaries.
(cont.) A principal contribution of this research is in demonstrating how different characteristics of the engineering artifact defined in terms of product complexity, architecture and technology newness, and different aspects of problem solving including problem type and novelty, drive the knowledge integration process and the organizational system. We conclude that permeability of cross-program boundaries, direct relationships with functional groups and rich tacit knowledge flow from suppliers are critical for countering rampant firefighting in complex product development.
by Marc George Haddad.
Ph.D.
49
Woodward, Claire J. D. A. "Identifying genes that mediate shoot meristemless function during meristem development in Arabidopsis thaliana." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268550.
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Muñoz, Daniel M. Eng Massachusetts Institute of Technology, and Virgüez Myriam Liliana Rivera. "Development of Panama as a logistics hub and the impact on Latin America." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61183.
Full textAbstract:
Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 82-86).
The Panamanian government is executing an aggressive economic growth initiative to transform the country into a regional logistics hub, like Singapore or Dubai. Two elements of the initiative are expansion of the Panama Canal and development of the Panama Pacifico Project, a large logistics park. The government initiative is analyzed with respect to the logistics hubs in Singapore and Dubai by 1) identifying a structure of critical factors for developing a logistics cluster, 2) using this structure to analyze the feasibility of Panama becoming a major logistics hub, and 3) exploring the impact of a logistics_hub in Panama on the Latin American network of ports. We make recommendations so that Panama can speedily develop its logistics hub, and so that Latin American ports whose existence is threatened by this development can adapt.
by Daniel Muñoz and Myriam Liliana Rivera.
M.Eng.in Logistics