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Journal articles on the topic 'DKED'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Alabish, Ahmed, Wjdan mohammed, Manal ghoumah, and Ali Dowa. "Evaluating the Accuracy of DKED and Fresnel Diffraction Models for Human Body Blockage in Indoor 5G Band Communications." Academy Journal For Basic and Applied Sciences 7, no. 1 (2025): 1–4. https://doi.org/10.5281/zenodo.15370402.

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<strong>This paper investigates human-induced signal attenuation in indoor mm-wave communications at 32.5 GHz, a critical concern for 5G systems. Two distinct diffraction-based models are applied to the same indoor scenario to assess human blockage effects: one employs the Double Knife-Edge Diffraction (DKED) approach, and the other uses Fresnel diffraction principles with complex Fresnel integrals. Controlled experiments with a human subject moving between a transmitter (TX) and a receiver (RX) reveal that the DKED model consistently underestimates the received power by 2–6 dB, while th

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Dalveren, Yaser, Gokhan Karatas, Mohammad Derawi, and Ali Kara. "A Simple Propagation Model to Characterize the Effects of Multiple Human Bodies Blocking Indoor Short-Range Links at 28 GHz." Electronics 10, no. 3 (2021): 305. http://dx.doi.org/10.3390/electronics10030305.

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This study aims to provide a simple approach to characterize the effects of scattering by human bodies in the vicinity of a short-range indoor link at 28 GHz while the link is fully blocked by another body. In the study, a street canyon propagation characterized by a four-ray model is incorporated to consider the human bodies. For this model, the received signal is assumed to be composed of a direct component that is exposed to shadowing due to a human body blocking the link and a multipath component due to reflections from human bodies around the link. In order to predict the attenuation due

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3

Adelman, Elizabeth. "When the Personal Becomes the Professional: Exploring the Lived Experiences of Syrian Refugee Educators." Special Issue on Refugee Education 5, no. 1 (2019): 94–122. http://dx.doi.org/10.33682/dkey-2388.

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Teachers play a central role in supporting students whose lives have been disrupted by crisis, yet the teachers providing education to refugee students often are refugees themselves. This article explores how being a teacher influences the experience of being a refugee and, conversely, how the experience of being a refugee influences the teacher’s role. I present portraits of two Syrian educators living as refugees in Lebanon who are working to educate refugee students. I find that that these two educators struggle to balance their teaching obligations with the realities of living as refugees

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4

Chen, P. P. S., and R. P. van de Riet. "DKE 40." Data & Knowledge Engineering 41, no. 2-3 (2002): 125–32. http://dx.doi.org/10.1016/s0169-023x(02)00036-8.

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5

Tan, Carlyn, Kylee H. Maclachlan, David Nemirovsky, et al. "Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) and Daratumumab, Carfilzomib, Lenalidomide and Dexamethasone (DKRd) As Induction Therapy in Newly Diagnosed Multiple Myeloma." Blood 142, Supplement 1 (2023): 4744. http://dx.doi.org/10.1182/blood-2023-181868.

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Background: Daratumumab, bortezomib, lenalidomide, dexamethasone (DVRd) and daratumumab, carfilzomib, lenalidomide, dexamethasone (DKRd) are promising induction regimens for newly diagnosed multiple myeloma (NDMM), resulting in deep responses and high minimal residual disease (MRD) negativity rates. Our prior work demonstrated progression-free survival (PFS) benefit in patients with high-risk (HR) NDMM receiving KRd versus VRd. Herein, we examined early outcomes associated with DVRd and DKRd induction in the management of patients with NDMM. Methods: We conducted a chart review study with NDMM

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Harwood, Jake. "Comparing Grandchildren's and Grandparents' Stake in Their Relationship." International Journal of Aging and Human Development 53, no. 3 (2001): 195–210. http://dx.doi.org/10.2190/tunx-h3ge-vf7v-dket.

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7

Hirst, Russel. "Herbert Spencer's Philosophy of Style: Conserving Mental Energy." Journal of Technical Writing and Communication 34, no. 4 (2004): 265–90. http://dx.doi.org/10.2190/d7g5-dkeu-y8a4-uvwu.

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8

Escriche, I., J. A. Serra, M. Gómez, and M. J. Galotto. "Effect of Ozone Treatment and Storage Temperature on Physicochemical Properties of Mushrooms (Agaris bisporus)." Food Science and Technology International 7, no. 3 (2001): 251–58. http://dx.doi.org/10.1106/6a9r-dkev-adv7-y30x.

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The aim of this paper was to determine the effect of ozone, storage time and temperature on postharvest quality of mushroom ( Agaris bisporus var. Gurelan 55). Mushrooms, treated with ozone (100 mg/h) during 0, 15 or 25 minutes, were packed in polystyrene packs, overwrapped with PVC plastic film, and stored at 5, 15 or 25 °C for seven days. Internal and external lightness ( L*) texture properties, maturity index and weight loss were analyzed during storage. Ozone treatment on mushrooms prior to packaging caused an increase in external browning rate and a reduction of the internal browning rate

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9

Allison, Susan. "Protective circulating proteins in DKD." Nature Reviews Nephrology 17, no. 9 (2021): 572. http://dx.doi.org/10.1038/s41581-021-00467-7.

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10

Fessler, Beate. "DKD-Phänotypen und renale Hypoxie." CardioVasc 22, no. 6 (2022): 17. http://dx.doi.org/10.1007/s15027-022-2933-1.

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11

Abe, Takaaki. "Therapy for CKD and DKD." Folia Pharmacologica Japonica 158, no. 4 (2023): 319–25. http://dx.doi.org/10.1254/fpj.22133.

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12

Scilletta, Sabrina, Maurizio Di Marco, Nicoletta Miano, et al. "Update on Diabetic Kidney Disease (DKD): Focus on Non-Albuminuric DKD and Cardiovascular Risk." Biomolecules 13, no. 5 (2023): 752. http://dx.doi.org/10.3390/biom13050752.

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The classic description of diabetic kidney disease (DKD) involves progressive stages of glomerular hyperfiltration, microalbuminuria, proteinuria, and a decline in the estimated glomerular filtration rate (eGFR), leading to dialysis. In recent years, this concept has been increasingly challenged as evidence suggests that DKD presents more heterogeneously. Large studies have revealed that eGFR decline may also occur independently from the development of albuminuria. This concept led to the identification of a new DKD phenotype: non-albuminuric DKD (eGFR < 60 mL/min/1.73 m2, absence of albumi

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13

Du, Hongxuan, Kaiying He, Jing Zhao, Qicai You, Xiaochun Zhou, and Jianqin Wang. "Co-differential genes between DKD and aging: implications for a diagnostic model of DKD." PeerJ 12 (February 29, 2024): e17046. http://dx.doi.org/10.7717/peerj.17046.

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Objective Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM) that is closely related to aging. In this study, we found co-differential genes between DKD and aging and established a diagnostic model of DKD based on these genes. Methods Differentially expressed genes (DEGs) in DKD were screened using GEO datasets. The intersection of the DEGs of DKD and aging-related genes revealed DKD and aging co-differential genes. Based on this, a genetic diagnostic model for DKD was constructed using LASSO regression. The characteristics of these genes were investigated using

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14

Sun, Zhenzhen, Kun Wang, Joshua D. Miller, Xiaodan Yuan, Yau-Jiunn Lee, and Qingqing Lou. "External validation of the risk prediction model for early diabetic kidney disease in Taiwan population: a retrospective cohort study." BMJ Open 12, no. 12 (2022): e059139. http://dx.doi.org/10.1136/bmjopen-2021-059139.

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ObjectivesThis study aims to independently and externally validate the Risk Prediction Model for Diabetic Kidney Disease (RPM-DKD) in patients with type 2 diabetes mellitus (T2DM).DesignThis is a retrospective cohort study.SettingOutpatient clinics at Lee’s United Clinics, Taiwan, China.ParticipantsA total of 2504 patients (average age 55.44 years, SD, 7.49 years) and 4455 patients (average age 57.88 years, SD, 8.80 years) were included for analysis in the DKD prediction and progression prediction cohorts, respectively.ExposureThe predicted risk for DKD and DKD progression for each patient wer

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15

Tofilski, Adam. "DKey software for editing and browsing dichotomous keys." ZooKeys 735 (February 6, 2018): 131–40. http://dx.doi.org/10.3897/zookeys.735.21412.

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16

Guo, Xiaobo, Wenfang Lin, Youru Li, et al. "DKEN: Deep knowledge-enhanced network for recommender systems." Information Sciences 540 (November 2020): 263–77. http://dx.doi.org/10.1016/j.ins.2020.06.041.

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Tofilski, Adam. "DKey software for editing and browsing dichotomous keys." ZooKeys 735 (February 6, 2018): 131–40. https://doi.org/10.3897/zookeys.735.21412.

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Despite advances in computer technology and the increasing availability of multiple-access taxonomic keys, traditional dichotomous keys remain the most often used taxonomic identification tools. On the other hand, there seems to be a lack of an editor of dichotomous keys, which is both freely available and easy to use. The DKey software was developed in order to alleviate this problem. A taxonomic key in text format can be imported to the software in order to edit it. Various editing options are possible, including: moving couplets, removing couplets, combining keys and renumbering keys. The s

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18

Fabre, Larissa, Juliana Figueredo Pedregosa-Miguel, and Érika Bevilaqua Rangel. "Proteinuric and Non-Proteinuric Diabetic Kidney Disease: Different Presentations of the Same Disease?" Diabetology 5, no. 4 (2024): 389–405. http://dx.doi.org/10.3390/diabetology5040030.

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Background: Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease (ESKD) worldwide. This review examines the potential differences in clinical presentation, outcomes, and management between individuals with proteinuric DKD (P-DKD) and non-proteinuric DKD (NP-DKD). Methods: We analyzed articles published globally from 2000 and 2024. Results: Individuals with NP-DKD generally have lower blood pressure levels and a more favorable lipid profile. In contrast, histological studies show that P-DKD is associated with more severe glomerulosclerosis, mesangial expansion, arteriola

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19

Gao, Tianrui, Jia Lv, Lizhen Lu, et al. "Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis." BMJ Open Diabetes Research & Care 12, no. 6 (2024): e004454. https://doi.org/10.1136/bmjdrc-2024-004454.

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IntroductionThe balance of trace elements plays an important role in diabetic kidney disease (DKD) patients. However, studies on the differences in urinary trace elements across different DKD stages are scarce. This study aimed to explore the associations between nine essential trace elements and DKD.Research design and methodsThis cross-sectional analysis included 830 diabetic patients. Participants were classified into non-DKD (NDKD) and DKD, the latter was further grouped into mid and end DKD based on estimated glomerular filtration rate (eGFR), and the case and control were matched based o

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20

Tserga, Aggeliki, Despoina Pouloudi, Jean Sébastien Saulnier-Blache, et al. "Proteomic Analysis of Mouse Kidney Tissue Associates Peroxisomal Dysfunction with Early Diabetic Kidney Disease." Biomedicines 10, no. 2 (2022): 216. http://dx.doi.org/10.3390/biomedicines10020216.

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Background: The absence of efficient inhibitors for diabetic kidney disease (DKD) progression reflects the gaps in our understanding of DKD molecular pathogenesis. Methods: A comprehensive proteomic analysis was performed on the glomeruli and kidney cortex of diabetic mice with the subsequent validation of findings in human biopsies and omics datasets, aiming to better understand the underlying molecular biology of early DKD development and progression. Results: LC–MS/MS was employed to analyze the kidney proteome of 2 DKD models: Ins2Akita (early and late DKD) and db/db mice (late DKD). The a

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21

Habsari, Pusparini, Dian Ariningrum, and Laily Shofiyah. "Serum Angiopoeitin Like-4 As An Early Detection Marker Of Diabetic Kidney Disease." Eduvest - Journal of Universal Studies 4, no. 6 (2024): 5398–415. http://dx.doi.org/10.59188/eduvest.v4i6.1459.

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Diabetic kidney disease (DKD) is a long-term complication of diabetes mellitus (DM). The gold standard for diagnosis of DKD is kidney biopsy, but it is difficult to perform. Several clinical conditions have found an association between higher ANGPTL4 plasma levels in DKD. Methods: A total of 87 patients with Type 2 DM were analysed using an observational analytic method with a cross-sectional design. The study subjects were divided into DKD and non DKD groups, then serum ANGPTL4 was measured using the sandwich ELISA method. Furthermore, ANGPTL index cutoff was determined. Several other variabl

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22

Leitgeb, Stefan, Grit D. Straganz, and Bernd Nidetzky. "Biochemical characterization and mutational analysis of the mononuclear non-haem Fe2+ site in Dke1, a cupin-type dioxygenase from Acinetobacter johnsonii." Biochemical Journal 418, no. 2 (2009): 403–11. http://dx.doi.org/10.1042/bj20081161.

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β-Diketone-cleaving enzyme Dke1 is a homotetrameric Fe2+-dependent dioxygenase from Acinetobacter johnsonii. The Dke1 protomer adopts a single-domain β-barrel fold characteristic of the cupin superfamily of proteins and features a mononuclear non-haem Fe2+ centre where a triad of histidine residues, His-62, His-64 and His-104, co-ordinate the catalytic metal. To provide structure–function relationships for the peculiar metal site of Dke1 in relation to the more widespread 2-His-1-Glu/Asp-binding site for non-haem Fe2+, we replaced each histidine residue individually with glutamate and asparagi

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23

Roy, Satyajeet, Olga Schweiker-Kahn, Behjath Jafry, et al. "Risk Factors and Comorbidities Associated with Diabetic Kidney Disease." Journal of Primary Care & Community Health 12 (January 2021): 215013272110485. http://dx.doi.org/10.1177/21501327211048556.

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Introduction/objectives: Diabetic Kidney Disease (DKD) is the leading cause of end-stage kidney disease. Despite optimal glycemic control and blood pressure management, progression to DKD cannot be halted in some patients. We aimed to find the association of modifiable and non-modifiable risk factors and comorbid conditions in patients with DKD. Methods: Retrospective medical record review of adult patients with diabetes mellitus (DM) was performed who visited our internal medicine office between January 1, 2020 and December 31, 2020. Results: Among 728 patients with DM, 471 (64.7%) patients h

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Bae, Jaehyun, and Byung-Wan Lee. "Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease." Biomedicines 11, no. 7 (2023): 1928. http://dx.doi.org/10.3390/biomedicines11071928.

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Metabolic-associated fatty liver disease (MAFLD) and diabetic kidney disease (DKD) share various pathophysiological factors, and epidemiological evidence suggests that these two diseases are associated. Albuminuria and the estimated glomerular filtration rate, which are conventional biomarkers of DKD, are reportedly associated with the risk or severity of MAFLD. Recently, novel DKD biomarkers reflecting renal tubular injury have been introduced to complement conventional DKD markers. In this article, we looked at previous studies that showed an association between MAFLD and DKD, and also revie

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Kelsey, Rebecca. "ASK1 inhibition shows potential in DKD." Nature Reviews Nephrology 14, no. 11 (2018): 658. http://dx.doi.org/10.1038/s41581-018-0063-x.

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26

van de Riet, R. P. "Notes on a classification for DKE." Data & Knowledge Engineering 41, no. 2-3 (2002): 133–39. http://dx.doi.org/10.1016/s0169-023x(02)00037-x.

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27

Sakashita, Midori, Tetsuhiro Tanaka, and Reiko Inagi. "Metabolic Changes and Oxidative Stress in Diabetic Kidney Disease." Antioxidants 10, no. 7 (2021): 1143. http://dx.doi.org/10.3390/antiox10071143.

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Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease, and it is crucial to understand the pathophysiology of DKD. The control of blood glucose levels by various glucose-lowering drugs, the common use of inhibitors of the renin–angiotensin system, and the aging of patients with diabetes can alter the disease course of DKD. Moreover, metabolic changes and associated atherosclerosis play a major role in the etiology of DKD. The pathophysiology of DKD is largely attributed to the disruption of various cellular stress responses due to metabolic changes, especially an increase

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Wang, Ling, Jia-Fen Cheng, Li-Ping Sun, et al. "Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/732317.

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Purpose.To investigate the relationship between uric acid and renal microvascular perfusion in diabetic kidney disease (DKD) using contrast-enhanced ultrasound (CEUS) method.Materials and Methods.79 DKD patients and 26 healthy volunteers were enrolled. Renal function and urine protein markers were tested. DKD patients were subdivided into two groups including a normal serum uric acid (SUA) group and a high SUA group. Contrast-enhanced ultrasound (CEUS) was performed, and low acoustic power contrast-specific imaging was used for quantitative analysis.Results.Normal controls (NCs) had the highes

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Watanabe, Kimio, Emiko Sato, Eikan Mishima, Mariko Miyazaki, and Tetsuhiro Tanaka. "What’s New in the Molecular Mechanisms of Diabetic Kidney Disease: Recent Advances." International Journal of Molecular Sciences 24, no. 1 (2022): 570. http://dx.doi.org/10.3390/ijms24010570.

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Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease, including end-stage kidney disease, and increases the risk of cardiovascular mortality. Although the treatment options for DKD, including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, sodium-glucose cotransporter 2 inhibitors, and mineralocorticoid receptor antagonists, have advanced, their efficacy is still limited. Thus, a deeper understanding of the molecular mechanisms of DKD onset and progression is necessary for the development of new and innovative treatments for DKD. The complex

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Raj, S. Baldha, P. SRINIVAS NAYAK S, Kamleshbhai Pandya Maulik, Buddhadev Mohit, and Chakraborthy Gunosindhu. "DIFFERENT METABOLIC PATHWAYS IN DIABETIC KIDNEY DISEASE AND RECENT ADVANCES IN SLOWING DISEASE PROGRESSION." EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH 8, no. 11 (2021): 269–76. https://doi.org/10.5281/zenodo.5641313.

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Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, clinical problem in terms of its diagnosis and management. Intensive glucose control in DKD could slow down but not significantly halt disease progression. Revisiting the tremendous advances that have occurred in the field would enhance recognition of DKD pathogenesis as well as improve our understanding of translational science in DKD in this new era. In this review, we summarize advances in the understanding the local microenviro

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Guo, Jia, Zhangsuo Liu, and Rujun Gong. "Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease." Clinical Science 133, no. 12 (2019): 1321–39. http://dx.doi.org/10.1042/cs20190372.

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AbstractDiabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in developed countries, with no definitive therapy yet available. It is imperative to decipher the exact mechanisms underlying DKD and identify novel therapeutic targets. Burgeoning evidence indicates that long non-coding RNAs (lncRNAs) are essential for diverse biological processes. However, their roles and the mechanisms of action remain to be defined in disease conditions like diabetes and DKD. The pathogenesis of DKD is tw

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32

Krisp, Jukka Matthias, and Stefan Peters. "Directed kernel density estimation (DKDE) for time series visualization." Annals of GIS 17, no. 3 (2011): 155–62. http://dx.doi.org/10.1080/19475683.2011.602218.

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Wang, Qi, Juyan Li, Zhedong Wang, and Yanfeng Zhu. "Revocable-Attribute-Based Encryption with En-DKER from Lattices." Mathematics 11, no. 24 (2023): 4986. http://dx.doi.org/10.3390/math11244986.

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Cloud computing offers abundant computing resources and scalable storage, but data leakage in the cloud storage environment is a common and critical concern due to inadequate protection measures. Revocable-attribute-based encryption (RABE) is introduced as an advanced form of identity-based encryption (IBE), which encrypts sensitive data while providing fine-grained access control and an effective user revocation mechanism. However, most existing RABE schemes are not resistant to quantum attacks and are limited in their application scenarios due to the revocation model. In this paper, we propo

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Lin, Huan-Tang, Mei-Ling Cheng, Chi-Jen Lo, Gigin Lin, and Fu-Chao Liu. "Metabolomic Signature of Diabetic Kidney Disease in Cerebrospinal Fluid and Plasma of Patients with Type 2 Diabetes Using Liquid Chromatography-Mass Spectrometry." Diagnostics 12, no. 11 (2022): 2626. http://dx.doi.org/10.3390/diagnostics12112626.

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Diabetic kidney disease (DKD) is the major cause of end stage renal disease in patients with type 2 diabetes mellitus (T2DM). The subtle metabolic changes in plasma and cerebrospinal fluid (CSF) might precede the development of DKD by years. In this longitudinal study, CSF and plasma samples were collected from 28 patients with T2DM and 25 controls, during spinal anesthesia for elective surgery in 2017. These samples were analyzed using liquid chromatography-mass spectrometry (LC-MS) in 2017, and the results were correlated with current DKD in 2017, and the development of new-onset DKD, in 202

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Zhao, Yunyun, Guanchi Yan, Jia Mi, et al. "The Impact of lncRNA on Diabetic Kidney Disease: Systematic Review and In Silico Analyses." Computational Intelligence and Neuroscience 2022 (April 27, 2022): 1–17. http://dx.doi.org/10.1155/2022/8400106.

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Background. Long noncoding RNA (lncRNA) is involved in the occurrence and development of diabetic kidney disease (DKD). It is necessary to identify the expression of lncRNA from DKD patients through systematic reviews, and then carry out silico analyses to recognize the dysregulated lncRNA and their associated pathways. Methods. The study searched Pubmed, Embase, Cochrane Library, WanFang, VIP, CNKI, and CBM to find lncRNA studies on DKD published before March 1, 2021. Systematic review of the literature on this topic was conducted to determine the expression of lncRNA in DKD and non-DKD contr

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Li, Yangyang, Li Jin, Jing Yan, Hong Zhang, Rong Zhang, and Cheng Hu. "CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study." Mediators of Inflammation 2021 (April 17, 2021): 1–10. http://dx.doi.org/10.1155/2021/5521050.

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Few studies have illuminated the genetic role of T cell costimulatory molecule CD28/CD80/CTLA4 variants in diabetic kidney disease (DKD) susceptibility. We aimed to investigate the causal role of genetic polymorphisms in CD28/CD80/CTLA4 with DKD susceptibility in patients with T2DM. A total of 3253 patients with T2DM were recruited for genotyping: including 204 DKD patients and 371 controls in stage 1 and 819 DKD patients and 563 controls in stage 2; besides, 1296 T2DM patients were selected for the analysis of association between loci and DKD-related traits. A subset of 227 T2DM patients (118

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Liu, Yan, Chanyue Zhao, Xiaofen Xiong, Ming Yang, and Lin Sun. "Insulin therapy in diabetic kidney disease." Diabetic Nephropathy 1, no. 2 (2021): 67–76. http://dx.doi.org/10.2478/dine-2022-0006.

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Abstract Diabetic kidney disease (DKD) is the main cause of end-stage renal disease (ESRD). The use of insulin represents a challenge in patients with DKD due to the patient and medication issues. Insulin regimens, insulin dosing, and titration need to be individualized based on the patient's age, renal function, and comorbidities to improve glycemic control and reduce the risk of hypoglycemia. Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) and DKD. For patients with type 2 diabetes mellitus (T2DM) and early stage of DKD, basal insulin combined with oral

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Tziastoudi, Maria, Georgios Pissas, Spyridon Golfinopoulos, et al. "Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study." International Journal of Molecular Sciences 25, no. 20 (2024): 10906. http://dx.doi.org/10.3390/ijms252010906.

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Diabetic kidney disease (DKD) is a serious microvascular complication of type 2 diabetes mellitus (T2DM). Despite the numerous genetic loci that have been associated with the disease in T2DM, the genetic architecture of DKD remains unclear until today. In contrast to SERPINE1, the contribution of SERPINB2 has not been examined in DKD. Therefore, we conducted the first genetic association study of SERPINB2 to elucidate its role in DKD. In total, the study involved 197 patients with DKD, 155 patients with T2DM without microvascular complications (diabetic kidney disease, diabetic retinopathy, an

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Matoba, Keiichiro, Yusuke Takeda, Yosuke Nagai, Daiji Kawanami, Kazunori Utsunomiya, and Rimei Nishimura. "Unraveling the Role of Inflammation in the Pathogenesis of Diabetic Kidney Disease." International Journal of Molecular Sciences 20, no. 14 (2019): 3393. http://dx.doi.org/10.3390/ijms20143393.

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Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease (ESRD) and is therefore a major burden on the healthcare system. Patients with DKD are highly susceptible to developing cardiovascular disease, which contributes to increased morbidity and mortality rates. While progress has been made to inhibit the acceleration of DKD, current standards of care reduce but do not eliminate the risk of DKD. There is growing appreciation for the role of inflammation in modulating the process of DKD. The focus of this review is on providing an overview of the current status of know

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Ghotekar, L. H., and Monika Yadav. "Current Strategies for Preventing Diabetic Kidney Disease." International Journal of Advanced Medical and Health Research 12, no. 1 (2025): 4–11. https://doi.org/10.4103/ijamr.ijamr_153_24.

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Diabetes is the most common cause of chronic kidney disease worldwide. Since there is a substantial increase in the prevalence of type 2 diabetes, it is likely that cases of diabetic kidney disease (DKD) will also rise unless some preventive measures are taken. DKD is associated with higher cardiovascular and all-cause mortality and morbidity; hence, prevention of DKD is essential. Classically, DKD evolves through several stages of normoalbuminuria, moderately increased albuminuria, and severely increased albuminuria. However, a substantial proportion of DKD has a nonproteinuric phenotype. Alb

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Guo, Man, Fangfang He, and Chun Zhang. "Molecular Therapeutics for Diabetic Kidney Disease: An Update." International Journal of Molecular Sciences 25, no. 18 (2024): 10051. http://dx.doi.org/10.3390/ijms251810051.

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Diabetic kidney disease (DKD) is a common microvascular complication of diabetes mellitus (DM). With the increasing prevalence of DM worldwide, the incidence of DKD remains high. If DKD is not well controlled, it can develop into chronic kidney disease or end-stage renal disease (ESRD), which places considerable economic pressure on society. Traditional therapies, including glycemic control, blood pressure control, blood lipid control, the use of renin–angiotensin system blockers and novel drugs, such as sodium–glucose cotransporter 2 inhibitors, mineralocorticoid receptor inhibitors and gluca

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Sultana, Dr Naznin, Dr Jamsed Faridi, Dr Md Mahboobur Rahman Bhuyan, Dr Md Mahfuzul Alam, Dr Md Abdul Khaleque, and Dr Tariq Reza Ali. "Effect of Intravitreal Bevacizumab (Anti VEGF) Injection on Renal Function." Saudi Journal of Medical and Pharmaceutical Sciences 10, no. 11 (2024): 782–88. http://dx.doi.org/10.36348/sjmps.2024.v10i11.002.

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Background: Vascular endothelial growth factor (VEGF) plays an important role in the development of both Proliferative Diabetic Retinopathy (PDR) & Diabetic Macular Odema (DMO). An intravitreal anti-VEGF agent is an effective new modality of treatment. Some studies have dealt with systemic effects of intravitreal injection of anti-VEGF. However, decreasing renal function has been reported recently. Aims: To investigate the effect of intravitreal bevacizumab (anti VEGF) injection on renal function. Methods: This quasi-experimental study was carried out in the Department of ophthalmology, Ba

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Tan, Ken-Soon, Stephen McDonald, and Wendy Hoy. "The Diagnostic Performance of a Clinical Diagnosis of Diabetic Kidney Disease." Life 13, no. 7 (2023): 1492. http://dx.doi.org/10.3390/life13071492.

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Background: Diabetic kidney disease (DKD), a common cause of CKD and kidney failure, is usually diagnosed clinically. However, there is little evidence comparing the performance of a clinical diagnosis to biopsy-proven diagnosis. Purpose of the study: Diagnostic performance of a clinical diagnosis was determined in a group of patients with diabetes and chronic kidney disease who underwent kidney biopsy after an initial clinical diagnosis. Methods: A data analysis of 54 patients who were part of a study cohort for a prospective analysis of cardiovascular and kidney outcomes and who had undergon

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Ghafoor, AtaUllah, Muhammad Sher, Muhammad Imran, and Imran Baig. "Disjoint Key Establishment Protocol for Wireless Sensor and Actor Networks." Journal of Sensors 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/5071617.

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Key distribution is essential for providing secure communication between commercial and sensitive applications of wireless sensor and actor networks (WSANs). It becomes more challenging when any of the intermediate sensor nodes is compromised by the adversaries as the messages carrying secure keys will be exposed and links will be unreliable. This paper presents a Disjoint Key Establishment Protocol (DKEP) that does not require transmitting keys across the nodes. In DKEP, each node is preloaded with one row and one column from a matrix. After the deployment, indices for row and column are exch

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Shang, Jianan, Yixuan Zheng, Meng Zhang, et al. "Lower Free Thyroxine Levels Are Associated with Diabetic Kidney Disease in Males with Type 2 Diabetes Mellitus: An Observational Cross-Sectional Study." Biomedicines 12, no. 10 (2024): 2370. http://dx.doi.org/10.3390/biomedicines12102370.

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Objectives: We aimed to explore the correlation between thyroid function and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 7516 T2DM patients were enrolled and grouped according to DKD status. Clinical parameters, including blood glucose parameters, thyroid function, and indicators of renal impairment, were collected and compared between the DKD and Non-DKD groups. Correlation analysis and univariate/multivariate logistic regression analyses were performed. Results: Age, T2DM duration, the use of insulin and lipid-lowering drugs, systolic a

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Yang, Yichen, Jiahui Liu, Qiling Shi, et al. "Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy." Biomolecules 14, no. 6 (2024): 733. http://dx.doi.org/10.3390/biom14060733.

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Diabetic kidney disease (DKD) is a common microvascular complication of diabetes and the main cause of end-stage renal disease around the world. Mitochondria are the main organelles responsible for producing energy in cells and are closely involved in maintaining normal organ function. Studies have found that a high-sugar environment can damage glomeruli and tubules and trigger mitochondrial dysfunction. Meanwhile, animal experiments have shown that DKD symptoms are alleviated when mitochondrial damage is targeted, suggesting that mitochondrial dysfunction is inextricably linked to the develop

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Wang, Yiting, Junlin Zhang, Yingwang Zhao, et al. "COL4A3 Gene Variants and Diabetic Kidney Disease in MODY." Clinical Journal of the American Society of Nephrology 13, no. 8 (2018): 1162–71. http://dx.doi.org/10.2215/cjn.09100817.

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Background and objectivesDespite advances in identifying genetic factors of diabetic kidney disease (DKD), much of the heritability remains unexplained. Nine maturity-onset diabetes in young (MODY) probands with kidney biopsy-proven DKD were selected and included in this study. The probands had more severe DKD compared with their parents with MODY, with overt proteinuria or rapid progression to ESKD. We aimed to explore the contribution of the variants in susceptibility genes of DKD to the severity of kidney phenotype between the probands and their parents.Design, setting, participants, &

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Li, Jiaqi, Keyu Guo, Junlin Qiu, et al. "Epidemiological status, development trends, and risk factors of disability-adjusted life years due to diabetic kidney disease: A systematic analysis of Global Burden of Disease Study 2021." Chinese Medical Journal, January 24, 2025. https://doi.org/10.1097/cm9.0000000000003428.

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Abstract Background: Approximately 40% of individuals with diabetes worldwide are at risk of developing diabetic kidney disease (DKD), which is not only the leading cause of kidney failure, but also significantly increases the risk of cardiovascular disease, causing significant societal health and financial burdens. This study aimed to describe the burden of DKD and explore its cross-country epidemiological status, predict development trends, and assess its risk factors and sociodemographic transitions. Methods: Based on the Global Burden of Diseases (GBD) Study 2021, data on DKD due to type 1

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Yan, Pijun, Yuxia Yang, Xing Zhang, et al. "Association of systemic immune-inflammation index with diabetic kidney disease in patients with type 2 diabetes: a cross-sectional study in Chinese population." Frontiers in Endocrinology 14 (January 4, 2024). http://dx.doi.org/10.3389/fendo.2023.1307692.

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ObjectiveSystemic immune-inflammation index (SII), a novel inflammatory marker, has been reported to be associated with diabetic kidney disease (DKD) in the U.S., however, such a close relationship with DKD in other countries, including China, has not been never determined. We aimed to explore the association between SII and DKD in Chinese population.MethodsA total of 1922 hospitalized patients with type 2 diabetes mellitus (T2DM) included in this cross-sectional study were divided into three groups based on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (A

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Wang, Jingyu, Juhong Yang, Wenhui Jiang, et al. "Effect of semaglutide on primary prevention of diabetic kidney disease in people with type 2 diabetes: A post hoc analysis of the SUSTAIN 6 randomized controlled trial." Diabetes, Obesity and Metabolism, August 27, 2024. http://dx.doi.org/10.1111/dom.15860.

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AbstractAimEfficient primary prevention of diabetic kidney disease (DKD) is currently lacking. The identification of people at high DKD risk and timely intervention are key to preventing DKD. Therefore, a model to classify people according to their risk for developing DKD was developed previously and used in the current analysis to assess the effect of semaglutide versus placebo on primary DKD prevention.MethodsParticipants with type 2 diabetes from the randomized, double‐blind, placebo‐controlled SUSTAIN 6 trial without DKD at baseline who received 0.5/1.0 mg semaglutide or placebo were group

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