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Journal articles on the topic 'DL-penicillamine'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Bhushan, Ravi, and Rajender Kumar. "Enantioresolution of dl-penicillamine." Biomedical Chromatography 24, no. 1 (2010): 66–82. http://dx.doi.org/10.1002/bmc.1355.

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2

Kodama, Hiroko, Yasumi Anan, Yoichi Izumi, Yasuhiro Sato, and Yasumitsu Ogra. "Copper and zinc concentrations in the breast milk of mothers undergoing treatment for Wilson’s disease: a prospective study." BMJ Paediatrics Open 5, no. 1 (2021): e000948. http://dx.doi.org/10.1136/bmjpo-2020-000948.

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ObjectiveTo evaluate the concentrations of copper and zinc in the breast milk of mothers undergoing treatment for Wilson’s disease (WD) and clarify whether they can safely breast feed their infants.DesignThis was an observational and prospective study in an individual-based case series.SettingBreast milk samples were collected from participants across Japan from 2007 to 2018 at the Department of Pediatrics, Teikyo University in Tokyo. This was a primary-care level study. Clinical data were collected from the participants’ physicians.PatientsEighteen Japanese mothers with WD who were treated wi

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3

Badsar, Alireza, Zeynab Gholami, Morteza Rahbar Taramsari, Zahra Atrkar Roshan, Hamid Mohammadi Kojidi, and Monireh Aghajany Nasab. "The Biochemical Outcome of two Treatment Protocols in Patients With Opium-associated Lead Poisoning: A Cross-sectional Study in North of Iran." International Journal of Medical Toxicology and Forensic Medicine 11, no. 1 (2021): 32329.1–32329.8. http://dx.doi.org/10.32598/ijmtfm.v11i1.32329.

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Background: Lead is a potent toxin that targets heme synthesis and some antioxidant enzymes that induce oxidative stress. Lead exposure remains one of the significant health concerns all over the world. Chelating agents have been used as antidotes for acute and chronic lead poisoning. The present study was conducted to evaluate the biochemical outcome of two different chelating therapies. Methods: This descriptive cross-sectional study was performed in the Razi University Hospital, Rasht, Guilan. Fifty-six patients with a history of opium use were enrolled in the study who were treated symptom

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4

Røgeberg, E., J. Aaseth, and W. Lund. "CHEMICAL AFFINITY OF METHYLMERCURY TO D-PENICILLAMINE, GLUTATHIONE AND N-ACETYL-DL-PENICILLAMINE." Acta Pharmacologica et Toxicologica 59 (March 13, 2009): 555–57. http://dx.doi.org/10.1111/j.1600-0773.1986.tb02824.x.

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5

Heaster, Hope, and Patrick E. Hoggard. "d- and dl-penicillamine complexes of chromium(III)." Polyhedron 13, no. 3 (1994): 333–37. http://dx.doi.org/10.1016/s0277-5387(00)81641-1.

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6

Lifshitz, Matitiahu, and Jacov Levy. "Efficacy of d-Penicillamine in Reducing Lead Concentrations in Children: A Prospective, Uncontrolled Study." Journal of Pharmacy Technology 16, no. 3 (2000): 98–101. http://dx.doi.org/10.1177/875512250001600306.

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Objective: To evaluate the efficacy of oral d-penicillamine therapy in children with high blood lead concentrations. Design: A prospective, uncontrolled study. Methods and Patients: Seven children (2–16 y old; mean 8.7) with elevated blood lead concentrations but no symptoms of lead poisoning were treated with oral d-penicillamine. Lead-contaminated homemade flour as found to be the source of poisoning. Mean ± SD blood lead concentrations prior to therapy were 60.3 ± 12.9 μg/dL (range 47.8–83). Mean blood zinc protoporphyrin (ZPP) was 337.86 ± 58.55 μmol/mol hemoglobin (Hb) (range 247–394). Re

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7

Pandey, D. S., and U. C. Agarwala. "N-Acetyl-Dl-Penicillamine Thionitrite - A Potential Nitrosylating Agent." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 21, no. 3 (1991): 361–74. http://dx.doi.org/10.1080/15533179108018345.

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8

Subhasis, Mallick, Mandal Arup, K. Bera Biplab, et al. "Kinetic and mechanistic studies on the interaction of DL-penicillamine with di-µ-hydroxobis(bipyridyl)dipalladium(II) ion in aqueous solution." Journal of Indian Chemical Society Vol. 88, Jun 2011 (2011): 859–63. https://doi.org/10.5281/zenodo.5770231.

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Department of Chemistry, The University of Burdwan, Burdwan-713 104, West Bengal, India <em>E-mail</em> : alakghosh2002@yahoo.co.in Department of Chemistry, National Institute of Technology, Durgapur-713 209, West Bengal, India <em>Manuscript received 09 April 2010, revised 05 October 2010, accepted 28 October 2010</em> The kinetics of interaction between DL-penicillamlne and the title complex is a two-step process in which the first step is ligand dependent, but the second step is ligand independent and is assigned to ring closure. The rate and activation parameters, conductivity studies, IR

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9

PANDEY, D. S., and U. C. AGARWALA. "ChemInform Abstract: N-Acetyl-DL-penicillamine Thionitrite. A Potential Nitrosylating Agent." ChemInform 23, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199211090.

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10

Adrie, Christophe, Christoph Richter, Maria Bachelet, et al. "Contrasting effects of NO and peroxynitrites on HSP70 expression and apoptosis in human monocytes." American Journal of Physiology-Cell Physiology 279, no. 2 (2000): C452—C460. http://dx.doi.org/10.1152/ajpcell.2000.279.2.c452.

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The free radicals nitric oxide (·NO) and superoxide (O2 −·) react to form peroxynitrite (ONOO−), a highly toxic oxidant species. In this study we investigated the respective effects of NO and ONOO− in monocytes from healthy human donors. Purified monocytes were incubated for 6 or 16 h with a pure NO donor ( S-nitroso- N-acetyl-dl-penicillamine, 0–2 mM), an ·NO/ONOO− donor (3-morpholinosydnonimine chlorhydrate, 0–2 mM) with and without superoxide dismutase (200 IU/ml), or pure ONOO−. We provide evidence that 3-morpholinosydnonimine chlorhydrate alone represents a strong stress to human monocyte

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11

Perez-Benito, Joaquin F., Driss Lamrhari, and Conchita Arias. "Oxidation of DL-penicillamine by chromium(VI). Kinetics of formation of the thioester intermediate." Canadian Journal of Chemistry 72, no. 7 (1994): 1637–44. http://dx.doi.org/10.1139/v94-206.

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The kinetics of formation of the thioester involved as an intermediate in the reaction between chromium(VI) and DL-penicillamine in aqueous media (pH = 1–8) containing different buffers (acetate, citrate, and phosphate) has been studied by monitoring the disappearance of chromium(VI) at 370 nm and application of the initial-rates method. The initial rate is directly proportional to the initial concentrations of both oxidant and reductant, and the rate vs. pH plots show bell-shaped profiles. The reaction is catalyzed by the buffer present in the medium, the catalytic power of each buffer increa

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12

Komarova, A. D., A. S. Potapov, K. V. Savostyanov, et al. "Challenges in the diagnosis of Wilson’s disease in young children." Voprosy detskoj dietologii 22, no. 2 (2024): 13–21. https://doi.org/10.20953/1727-5784-2024-2-13-21.

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Objective. To evaluate the clinical course of Wilson’s disease (WD) and the effectiveness of a scoring algorithm for diagnosis in children with early onset of the disease. Patients and methods. Data from 85 case histories of children with WD observed at the National Medical Research Center for Children’s Health between 2012 and 2023 were retrospectively analyzed. Results. Clinical and laboratory manifestations of WD at the age of 5 years and under were observed in 36 children. The mean ransaminase level was 128 U/L for alanine aminotransferase and 82 U/L for aspartate aminotransferase. Cerulop

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13

Salas, E., M. A. Moro, S. Askew, et al. "Comparative pharmacology of analogues of S-nitroso-N-acetyl-dl-penicillamine on human platelets." British Journal of Pharmacology 112, no. 4 (1994): 1071–76. http://dx.doi.org/10.1111/j.1476-5381.1994.tb13192.x.

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14

Mocanu, Cristina-Manuela. "Occupational lead intoxication from terracotta tiles manufacturing: a case study." Romanian Journal of Occupational Medicine 73, no. 1 (2022): 12–17. http://dx.doi.org/10.2478/rjom-2022-0002.

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Abstract We report the case of a 63-year-old terracotta tiles manufacturer who presented with acute abdomen and normocytic anaemia. The patient presented with elevated levels of urinary delta-aminolaevulinic acid without any increase in the levels of urine porphobilinogen or urine coproporphyrin. Detection of elevated lead blood levels (1939 µg/dL one month before hospital admission in the occupational medicine clinic and 44.70 µg/dL at hospital admission, values come from two different laboratories) confirmed the diagnosis of chronic lead poisoning due to occupational exposure. Chelation ther

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15

Dixon, Donovan A., Tara P. Dasgupta, and Novelette P. Sadler. "Mechanism of the oxidation of DL-penicillamine and glutathione by chromium(VI) in aqueous solution." Journal of the Chemical Society, Dalton Transactions, no. 13 (1995): 2267. http://dx.doi.org/10.1039/dt9950002267.

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16

Kwiatkowski, P. A., J. Puc, W. Rowinski, and P. Fiedor. "Effects of DL-Penicillamine on Cytotoxic Reaction between Baboon Performed Xenoantibodies and Pig Endothelial Cells." International Journal of Artificial Organs 20, no. 7 (1997): 375–78. http://dx.doi.org/10.1177/039139889702000704.

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The purpose of this study was to evaluate effects of DL-Penicillamine (DLP), a compound interrupting S-S bonds (IgM pentamers) on binding and cytotoxicity of adult baboon performed xenoantibodies to pig endothelial cells. Pooled baboon serum was treated with different concentrations of DLP during various periods of time. Complement-mediated cytotoxicity assay was used to determine the reactivity of baboon xenoantibodies to pig aortic endothelial cells (PAEC). To assess IgM and IgG binding to PAEC, ELISA method was applied. Serum treated with DLP revealed significant reduction of cytotoxicity i

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17

Buglyó, Péter, Eszter Márta Nagy, and Imre Sóvágó. "Vanadium(III) binding strengths of small biomolecules." Pure and Applied Chemistry 77, no. 9 (2005): 1583–94. http://dx.doi.org/10.1351/pac200577091583.

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The hydrolysis of vanadium(III) and the complex formation reactions between V(III) and weakly coordinating [glycine (GLY), DL-aspartic acid (ASP), D-penicillamine (PEN), DL-histidine (HIS)] or strongly coordinating [N,O] donor [picolinic (PIC) or 6-methylpicolinic acid (MePIC)] and [O,O] donor [maltol (MALT), 1,2-dimethyl-3-hydroxy-4-(1H)-pyridinone (DHP), tiron (TIR)] ligands were studied at 25.0 °C and an ionic strength of 0.20 M (KCl) in aqueous solution using combined pH-potentiometric and UV-vis spectroscopic techniques. Although some interaction between the amino acids and V(III) was fou

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18

Chowdhury, Shahed Haider, Khondoker Ehsanul Arefin, and Mohsina Akter Lucky. "Wilson’s Disease- A Child with An Atypical Presentation." Scholars Journal of Medical Case Reports 12, no. 03 (2024): 271–73. http://dx.doi.org/10.36347/sjmcr.2024.v12i03.009.

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Wilson’s disease is a hereditary disorder of copper metabolism which leads to copper overload in different tissues of the body. Clinical presentation of Wilson disease can vary widely; therefore, diagnosis is not always straightforward. Here we report a 13-year-old girl presented with diffuse persistent stabbing pain in the abdomen, jaundice & dark urine. She had no history of unconsciousness, convulsion, deterioration of school performance, or alteration of sleep pattern. On examination, she was ill-looking, pale, and icteric. The liver was enlarged. Higher psychic Function was intact, wi

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19

Altun, Ahmet, Mustafa Ergül, Ali Kemal Filiz, Mesut Parlak, Merve Ergül, and Tijen Kaya Temiz. "The Effects of Daily Repeated Magnetic Field on S-Nitroso-N-acetyl-DL penicillamine Induced Hyperalgesia." Cumhuriyet Medical Journal 36, no. 3 (2014): 310. http://dx.doi.org/10.7197/cmj.v36i3.1008002547.

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20

Monroy, A., C. Ríos, and S. Montes. "Additive effect of dl-penicillamine plus Prussian blue for the antidotal treatment of thallotoxicosis in rats." Toxicology Letters 196 (July 2010): S303. http://dx.doi.org/10.1016/j.toxlet.2010.03.958.

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21

Montes, Sergio, Gabriela Pérez-Barrón, Moisés Rubio-Osornio, et al. "Additive effect of dl-penicillamine plus Prussian blue for the antidotal treatment of thallotoxicosis in rats." Environmental Toxicology and Pharmacology 32, no. 3 (2011): 349–55. http://dx.doi.org/10.1016/j.etap.2011.07.002.

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22

Gigante, A., C. Chillemi, D. Quaglino, M. Miselli, and I. Pasquali-Ronchetti. "DL-penicillamine induced alteration of elastic fibers of periosteum-perichondrium and associated growth inhibition: an experimental study." Journal of Orthopaedic Research 19, no. 3 (2001): 398–404. http://dx.doi.org/10.1016/s0736-0266(00)90033-0.

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23

Aaseth, Jan. "Mobilization of Methyl Mercury in Vivo and in Vitro using N-acetyl-DL-penicillamine and other Complexing Agents." Acta Pharmacologica et Toxicologica 39, no. 3 (2009): 289–301. http://dx.doi.org/10.1111/j.1600-0773.1976.tb03180.x.

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24

Frost, Megan C., and Mark E. Meyerhoff. "Controlled Photoinitiated Release of Nitric Oxide from Polymer Films ContainingS-Nitroso-N-acetyl-dl-penicillamine Derivatized Fumed Silica Filler." Journal of the American Chemical Society 126, no. 5 (2004): 1348–49. http://dx.doi.org/10.1021/ja039466i.

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25

Glotzer, Deborah E., and Howard Bauchner. "Management of Childhood Lead Poisoning: A Survey." Pediatrics 89, no. 4 (1992): 614–18. http://dx.doi.org/10.1542/peds.89.4.614.

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Published recommendations (1985) for the management of childhood lead poisoning suggest the use of ethylenediaminetetraacetic acid (EDTA)provocation testing and chelation as the mainstay of treatment for blood lead levels between 25 and 55 μg/dL. Since 1985 evidence has accumulated indicating that (1) levels of blood lead less than 25 μg/dL are detrimental to cognitive development, (2) EDTA provocation testing may result in potentially harmful shifts in the body lead burden, and (3) oral agents such as penicillamine and 2,3-dimercaptosuccinic acid are effective in reducing elevated lead levels

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26

Zastelo, Elena S., Elvira N. Fedulova, Anastasiya N. Gabrikevich, Tatiana V. Skochilova, and Anatoly I. Khavkin. "Wilson’s Disease. Onset and Complex Diagnosis: Clinical Case." Current Pediatrics 23, no. 6 (2025): 483–88. https://doi.org/10.15690/vsp.v23i6.2834.

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Background. The low prevalence of Wilson’s disease, diversity of clinical signs, long latent course, inheritance features make it difficult to diagnose and require multidisciplinary approach from doctors. Clinical case description. This article describes a clinical case of Wilson’s disease, rare hereditary multisystem disease, diagnosed in patient F., 13 years old. The disease onset was at the age of 6 masked by gastroesophageal reflux disease. Hepatomegaly, cytolysis, and cholestasis were diagnosed 4 years later, thus diagnosis of hepatitis of unknown origin was established requiring further

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27

Rao, Janapareddy Vijaya Bhaskara, Bhuma Vengamma, Thota Naveen, and Vandanapu Naveen. "Lead encephalopathy in adults." Journal of Neurosciences in Rural Practice 5, no. 02 (2014): 161–63. http://dx.doi.org/10.4103/0976-3147.131665.

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Lead poisoning is a common occupational health hazard in developing countries. We report the varied clinical presentation, diagnostic and management issues in two adult patients with lead encephalopathy. Both patients worked in a battery manufacturing unit. Both patients presented with seizures and one patient also complained of abdominal colic and vomiting. Both were anemic and a lead line was present. Blood lead level in both the patients was greater than 25 μg/dl. Magnetic resonance imaging of brain revealed bilateral symmetric involvement of the thalamus, lentiform nucleus in both patients

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28

Aaseth, Jan, Axel Wannag, and Tor Norseth. "The Effect of N-acetyJated DL-penicillamine and DL-homocysteine Thiolactone on the Mercury Distribution in Adult Rats, Rat Foetuses and Macaca Monkeys after Exposure to Methyl Mercuric Chloride." Acta Pharmacologica et Toxicologica 39, no. 3 (2009): 302–11. http://dx.doi.org/10.1111/j.1600-0773.1976.tb03181.x.

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29

Shi, Tiesheng, Johan Berglund, and Lars I. Elding. "Kinetics and Mechanism for Reduction oftrans-Dichlorotetracyanoplatinate(IV) by Thioglycolic Acid,l-Cysteine,dl-Penicillamine, and Glutathione in Aqueous Solution." Inorganic Chemistry 35, no. 12 (1996): 3498–503. http://dx.doi.org/10.1021/ic951598s.

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30

Askew, Stuart C., Anthony R. Butler, Frederick W. Flitney, Graham D. Kemp, and Ian L. Megson. "Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso-N-acetyl-dl-penicillamine and S-nitrosoglutathione." Bioorganic & Medicinal Chemistry 3, no. 1 (1995): 1–9. http://dx.doi.org/10.1016/0968-0896(94)00139-t.

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31

Pantel, Priya, and Swati Nagpal. "AYURVEDIC PROTOCOL FOR THE MANAGEMENT OF WILSON’S DISEASE – A CASE REPORT." International Ayurvedic Medical Journal 9, no. 7 (2021): 1593–96. http://dx.doi.org/10.46607/iamj4509072021.

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Wilson’s disease (hepatolenticular degeneration) is a rare important autosomal recessive disorder caused by dys- function of the copper transporter ATP7B, which leads to snagging in copper transport by the hepatic lysosomes resulted in the deposition of copper in the brain, liver, kidney, or skeletal system. The symptoms are jaundice, Kayser-Fleischer rings, dysarthria, ataxia, and muscle spasticity etc. Current therapeutic modalities for the manage- ment of Wilson's disease include zinc, trientine, penicillamine etc. In Ayurvedic classics there is no exact correlation is available for this di

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32

Bhushan, Ravi, та Rajender Kumar. "Analytical and preparative enantioseparation of dl-penicillamine and dl-cysteine by high-performance liquid chromatography on α-acid glycoprotein and β-cyclodextrin columns using ninhydrin as a reversible tagging reagent". Journal of Chromatography A 1216, № 15 (2009): 3413–17. http://dx.doi.org/10.1016/j.chroma.2009.02.015.

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33

Pope, M., P. A. Marsden, E. Cole, et al. "Resistance to Murine Hepatitis Virus Strain 3 Is Dependent on Production of Nitric Oxide." Journal of Virology 72, no. 9 (1998): 7084–90. http://dx.doi.org/10.1128/jvi.72.9.7084-7090.1998.

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ABSTRACT The strain-specific spectrum of liver disease following murine hepatitis virus type 3 (MHV-3) infection is dependent on inflammatory mediators released by macrophages. Production of nitric oxide (NO) by macrophages has been implicated in resistance to a number of viruses, including ectromelia virus, vaccinia virus, and herpes simplex virus type 1. This study was undertaken to define the role of NO in MHV-3 infection. Gamma interferon-induced production of NO inhibited growth of MHV-3 in a murine macrophage cell line (RAW 264.7). Viral inhibitory activity was reproduced by the NO donor

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34

Mang, Christian F., and Heinz Kilbinger. "Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP)." British Journal of Pharmacology 131, no. 1 (2000): 94–98. http://dx.doi.org/10.1038/sj.bjp.0703531.

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35

IOANNIDIS, Iosif, Michael BÄTZ, Thomas PAUL, Hans-Gert KORTH, Reiner SUSTMANN, and Herbert de GROOT. "Enhanced release of nitric oxide causes increased cytotoxicity of S-nitroso-N-acetyl-dl-penicillamine and sodium nitroprusside under hypoxic conditions." Biochemical Journal 318, no. 3 (1996): 789–95. http://dx.doi.org/10.1042/bj3180789.

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S-Nitroso-N-acetyl-dl-penicillamine (SNAP) and sodium nitroprusside (SNP), both of which are known to release nitric oxide (•NO), exhibited cytotoxicity against cultivated endothelial cells. Under hypoxic conditions 5 mM SNAP and 20 mM SNP induced a loss in cell viability of about 90% and 80% respectively, after an 8 h incubation. Under normoxic conditions, cell death was only 45% and 42% respectively within the same time period. Concentrations of •NO liberated from SNAP and SNP were measured by the oxyhaemoglobin method and by two of the recently developed nitric oxide cheletropic traps (NOCT

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36

Pravdic, Danijel, Nikolina Vladic, Ivan Cavar, and Zeljko J. Bosnjak. "Effect of nitric oxide donorsS-nitroso-N-acetyl-dl-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes." Clinical and Experimental Pharmacology and Physiology 39, no. 9 (2012): 772–78. http://dx.doi.org/10.1111/j.1440-1681.2012.05734.x.

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37

Shi, Tiesheng, Johan Berglund, and Lars I. Elding. "Kinetics and mechanisms for reduction of trans-dichlorotetracyanoplatinate(IV) by thioglycolic acid, L-cysteine, DL-penicillamine and glutathione in aqueous solution." Journal of Inorganic Biochemistry 59, no. 2-3 (1995): 277. http://dx.doi.org/10.1016/0162-0134(95)97380-9.

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38

Karmakar, Parnajyoti, Biplab K. Bera, Kanai L. Barik, Sudip K. Mukhopadhyay, and Alak K. Ghosh. "Kinetics and mechanism of the interaction of DL-penicillamine with cis-diaqua(cis-1,2-diaminocyclohexane)platinum(II) perchlorate in aqueous medium." Journal of Coordination Chemistry 63, no. 12 (2010): 2158–71. http://dx.doi.org/10.1080/00958972.2010.498910.

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39

Fa, Xinmeng, Shaowei Lin, Jianghua Yang, et al. "−808 nm-activated Ca²⁺ doped up-conversion nanoparticles that release no inducing liver cancer cell (HepG2) apoptosis." Methods and Applications in Fluorescence 10, no. 2 (2022): 024003. http://dx.doi.org/10.1088/2050-6120/ac5524.

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Abstract A near-infrared (NIR) light-triggered release method for nitric oxide (NO) was developed utilizing core/shell NaYF4: Tm/Yb/Ca@NaGdF4: Nd/Yb up-conversion nanoparticles (UCNPs) bearing a mesoporous silica (mSiO2) shell loaded with the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP). To avoid overheating in biological samples, Nd3+ was chosen as a sensitizer, Yb3+ ions as the bridging sensitizer, and Tm3+ ions as UV-emissive activator while co-doping with Ca2+ was done to enhance the luminescence of the activator Tm3+. NO release from SNAP was triggered by an NIR-UV up-conversion pr

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40

Yeh, Jui-Ning. "Combination of melatonin-delivered endothelial progenitor cells with S-nitroso-N-acetyl-DL-penicillamine for improving critical limb ischemia in the rat." American Journal of Translational Research 16, no. 9 (2024): 5020–37. http://dx.doi.org/10.62347/ocft1003.

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41

Hua, Jinsheng, Hui Yang, Xiufang Li, et al. "Cu(II)-functionalized silk fibroin films for the catalytic generation of nitric oxide." Biointerphases 17, no. 3 (2022): 031001. http://dx.doi.org/10.1116/6.0001690.

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In situ release of nitric oxide (NO) has been suggested to be a potential functionalization strategy for blood-contacting implants. In this study, the NO generation capability catalyzed by the copper ion-incorporated silk fibroin (SF) films in the presence of S-nitroso- N-acetyl-dl-penicillamine (SNAP) is demonstrated. Cu(II) is effectively bound to the surface of the SF film based on metal–protein coordination. The x-ray photoelectron spectroscopy results indicate that copper ions may exist on the surface of the SF film in the form of Cu(II)/Cu(I) coexistence. The degradation behavior showed

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42

Takhampunya, Ratree, R. Padmanabhan, and Sukathida Ubol. "Antiviral action of nitric oxide on dengue virus type 2 replication." Journal of General Virology 87, no. 10 (2006): 3003–11. http://dx.doi.org/10.1099/vir.0.81880-0.

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Recently, nitric oxide (NO) has been shown to suppress dengue virus (DENV) RNA and protein accumulation in infected cells. In this report, the potential target of the inhibitory effect of NO was studied at the molecular level. The NO donor, S-nitroso-N-acetylpenicillamine (SNAP), showed an inhibitory effect on RNA accumulation at around 8–14 h post-infection, which corresponded to the step of viral RNA synthesis in the DENV life cycle. The activity of the viral replicase isolated from SNAP-treated DENV-2-infected cells was suppressed significantly compared with that of the negative-control N-a

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Bayes, Farhana, ASM Bazlul Karim, Laila Helaly, et al. "Spectrum of Hepatic Presentation of Wilsons Disease in Children Attending A Tertiary Care Centre of Dhaka City." Bangladesh Journal of Child Health 38, no. 2 (2014): 86–93. http://dx.doi.org/10.3329/bjch.v38i2.21142.

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Background: The incidence of Wilsons disease (WD) is increasing day by day in every ethnic group worldwide. WD has been found as a common cause of chronic liver disease in children. This study was undertaken to find out the occurrence and different types of hepatic presentation of Wilsons disease in children admitted with liver diseases at a tertiary care centre of Bangladesh. Methodology: This cross sectional descriptive study was carried out at the department of Paediatric Gastroenterology and Nutrition, BSMMU during the period from March 2008 through April 2010. A total number of 71 child

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Haftu, Hansa, Mohammed Mustefa, and Teklu Gebrehiwot. "Zinc Monotherapy as an Alternative Treatment Option for Decompensated Liver Disease due to Wilson Disease?" Case Reports in Hepatology 2020 (January 14, 2020): 1–5. http://dx.doi.org/10.1155/2020/1275940.

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Background. Wilson disease is a rare metabolic disorder involving copper metabolism, and patients may present with a variable degree of hepatic, neurologic, and psychiatric manifestations. In the case of hepatic presentation, treatment is usually initiated with potentially toxic copper chelators (D-penicillamine or Trenton). Although zinc is of low toxicity and low cost for treatment of Wilson disease, it has been limited to the adjunctive as a single maintenance drug or for asymptomatic patients. The use of zinc monotherapy in patients suffering from a severe liver disease was not well studie

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‘t Hart, Daan, Jinhua Li, Johan van der Vlag, and Tom Nijenhuis. "Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury." International Journal of Molecular Sciences 22, no. 22 (2021): 12485. http://dx.doi.org/10.3390/ijms222212485.

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Increased expression and activity of the Ca2+ channel transient receptor potential channel 6 (TRPC6) is associated with focal segmental glomerulosclerosis, but therapeutic strategies to target TRPC6 are currently lacking. Nitric oxide (NO) is crucial for normal glomerular function and plays a protective role in preventing glomerular diseases. We investigated if NO prevents podocyte injury by inhibiting injurious TRPC6-mediated signaling in a soluble guanylate cyclase (sGC)-dependent manner and studied the therapeutic potential of the sGC stimulator Riociguat. Experiments were performed using h

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Aleksandrowicz, Marta, Beata Dworakowska, Krzysztof Dolowy, and Ewa Kozniewska. "Restoration of the response of the middle cerebral artery of the rat to acidosis in hyposmotic hyponatremia by the opener of large-conductance calcium sensitive potassium channels (BKCa)." Journal of Cerebral Blood Flow & Metabolism 37, no. 9 (2017): 3219–30. http://dx.doi.org/10.1177/0271678x16685575.

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Hyposmotic hyponatremia (the decrease of extracellular concentration of sodium ions from 145 to 121 mM and the decrease of hyposmolality from 300 to 250 mOsm/kg H2O) impairs response of the middle cerebral artery (MCA) to acetylcholine and NO donor (S-nitroso-N-acetyl-DL-penicillamine). Since acidosis activates a similar intracellular signaling pathway, the present study was designed to verify the hypothesis that the response of the MCA to acidosis is impaired during acute hyposmotic hyponatremia due to abnormal NO-related signal transduction in vascular smooth muscle cells. Studies performed

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Holliday, L. S., A. D. Dean, R. H. Lin, J. E. Greenwald, and S. L. Gluck. "Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism." American Journal of Physiology-Renal Physiology 272, no. 3 (1997): F283—F291. http://dx.doi.org/10.1152/ajprenal.1997.272.3.f283.

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High concentrations of nitric oxide (NO) inhibit bone resorption by mature osteoclasts. We examined the effects of low NO concentrations on osteoclast formation in mouse bone marrow cultures. The NO releasers sodium nitroprusside (SNP) and S-nitroso-N-acetyl-DL-penicillamine inhibited the formation of multinucleated cells expressing tartrate-resistant acid phosphatase (a marker for osteoclasts) when administered during the last 3 days of 6-day cultures (differentiation stage) but not during the first 3 days (proliferation stage). SNP (1 microM) completely inhibited pit formation on dentine waf

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Harraz, Osama F., Suzanne E. Brett, and Donald G. Welsh. "Nitric oxide suppresses vascular voltage-gated T-type Ca2+ channels through cGMP/PKG signaling." American Journal of Physiology-Heart and Circulatory Physiology 306, no. 2 (2014): H279—H285. http://dx.doi.org/10.1152/ajpheart.00743.2013.

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Recent reports have noted that T-type Ca2+ channels (CaV3.x) are expressed in vascular smooth muscle and are potential targets of regulation. In this study, we examined whether and by what mechanism nitric oxide (NO), a key vasodilator, influences this conductance. Using patch-clamp electrophysiology and rat cerebral arterial smooth muscle cells, we monitored an inward Ba2+ current that was divisible into a nifedipine-sensitive and -insensitive component. The latter was abolished by T-type channel blocker and displayed classic T-type properties including faster activation and steady-state inac

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Ungvari, Zoltan, and Akos Koller. "Selected Contribution: NO released to flow reduces myogenic tone of skeletal muscle arterioles by decreasing smooth muscle Ca2+sensitivity." Journal of Applied Physiology 91, no. 1 (2001): 522–27. http://dx.doi.org/10.1152/jappl.2001.91.1.522.

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To clarify the contribution of intracellular Ca2+ concentration ([Ca2+]i)-dependent and -independent signaling mechanisms in arteriolar smooth muscle (aSM) to modulation of arteriolar myogenic tone by nitric oxide (NO), released in response to increases in intraluminal flow from the endothelium, changes in aSM [Ca2+]i and diameter of isolated rat gracilis muscle arterioles (pretreated with indomethacin) were studied by fluorescent videomicroscopy. At an intraluminal pressure of 80 mmHg, [Ca2+]i significantly increased and myogenic tone developed in response to elevations of extracellular Ca2+

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Ioannidis, I., and H. de Groot. "Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: evidence for co-operative action with hydrogen peroxide." Biochemical Journal 296, no. 2 (1993): 341–45. http://dx.doi.org/10.1042/bj2960341.

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The NO-releasing compounds 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), sodium nitroprusside (SNP) and S-nitroso-N-acetyl-DL-penicillamine (SNAP) mediated a rapid loss of viability of Fu5 rat hepatoma cells. SIN-1 in addition to NO also released the superoxide anion radical (O2-.). Its cytotoxicity, however, was not affected by superoxide dismutase. In contrast, the H2O2-converting enzyme catalase significantly, but not completely, diminished cell damage, indicating participation of H2O2 in the tumoricidal activity of SIN-1. Glucose oxidase (5 m-units/ml), producing similar amounts of H2O

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