Academic literature on the topic 'DLBC'
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Journal articles on the topic "DLBC"
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Ogilvie, C., K. Lund, P. McKay, and M. Leach. "19 Extranodal or primary CNS DLBC lymphoma?" European Journal of Cancer Supplements 8, no. 4 (2010): 13. http://dx.doi.org/10.1016/s1359-6349(10)70690-x.
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Weyl Ben Arush, M., A. Hersalis Eldar, G. Abrahami, et al. "Burkitt lymphoma in children: The Israel Society of Pediatric Hematology Oncology retrospective study." Journal of Clinical Oncology 27, no. 15_suppl (2009): 10051. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10051.
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10051 Background: From 2000 to 2005, the Israel Society of Pediatric Hematology Oncology studied the results of the FAB-LMB 96 protocol in children with B cell lymphoma. Methods: Eighty eight patients (pts) were eligible, 63 boys, 25 girls, median age was 8.9 years. Fifty patients (57%) were classified as burkitt lymphoma, 5 (5.7%) as burkitt-like lymphoma, 22 (25%) as diffuse large B cell (DLBC), 9 (10.2%) as burkitt leukemia. Initial disease sites included the abdomen in 43%, head and neck in 45%, mediastinum in 7%. Stage I: 9.1%, Stage II in 28.4%, stage III in 45.5%, stage IV in 17%. Five pts had bone marrow involvement (BM) alone, 5 pts CNS alone and 4 both CNS and BM. Five children were treated according to group A, 69 pts group B and 14 pts group C. Results: At a median follow up of 3 years, Kaplan Meier for EFS and OS for all pts was respectively 88.6%, 90.9%, group A, 100%,100%, group B: 90%, 93%, group C 79%, 79%. In group A: there were neither events nor deaths in this group, 6 patients relapsed in group B, among them 4 patients had died, tumor lysis syndrome in 3 patients, death of toxicity in 1 patient. In group C, 3 patients had relapsed and died, no death of toxicity. EFS for LDH less then twice was 96.4%, EFS for LDH more than twice was 73.3% (p = 0.002). OS according to primary site: bone and ovary (100%), head and neck (95%), abdomen (92%) and mediastinum (50%) (p = 0.003). All of the mediastinal tumors were of DLBC origin, but when comparing the DLBC to other histologies, no significant difference in outcome were found.(DLBC: 81.8%, other B line: 90.9%). The OS for Arab ethnic origin is 79.2%, OS for Jewish is 95.3% (p = 0.02). Conclusions: In nonresected mature B cell lymphoma of childhood and adolescence with no BM or CNS involvement, a 93% cure rate was achieved. Patients with primary DLBC mediastinal mass had a significantly reduced overall survival, indicating the need for a different therapeutic approach. No significant financial relationships to disclose.
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Amorim, José M., Santiago Rosati, Ronit Agid, Vítor Mendes Pereira, and Timo Krings. "Treatment of an internal carotid artery aneurysm with a flow diverter through a double lumen balloon catheter." Interventional Neuroradiology 23, no. 3 (2017): 255–59. http://dx.doi.org/10.1177/1591019917691238.
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Background Double lumen balloon catheters (DLBCs) are currently used in the treatment of intracranial aneurysms, especially when involving balloon or stent-assisted coiling. The existing DLBCs allow the delivery of self-expandable stents but do not offer the possibility to deploy flow-diverters. Despite the increasing use and success of flow-diverters, there have been numerous reports of procedural complications such as early in-stent thrombosis or delayed distal embolization. It seems that these complications can be avoided by correct stent positioning and adequate wall apposition, achieved either by manoeuvres with the microguidewire and/or microcatheter or by performing balloon angioplasty following an exchange guidewire manoeuvre. Objective Report the use of a new DLBC able to deliver a flow-diverter. Methods A 41-year-old woman presented to our hospital with binocular horizontal diplopia for two weeks and reduced visual acuity. A left internal carotid artery aneurysm involving the cavernous and ophthalmic segments was found, with a maximum height of 19 mm and a broad 8 mm neck. It presented extra- and intra-dural components and the parent vessel was significantly narrowed. A decision was made to perform endovascular treatment of the aneurysm with placement of a flow diverter through a DLBC. Results Patency and adequate expansion of the flow diverter with evident intra-aneurysmal contrast stasis was observed in the final angiogram. No peri-procedural complications were observed. Conclusion This is a technical note demonstrating the feasibility of a new device to deploy a flow diverter, aiming to improve wall apposition and stent configuration without the need of additional devices or exchange manoeuvres.
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Vanazzi, Anna, Pier Francesco Ferrucci, Chiara Maria Grana, et al. "Efficacy of 90 Y - Ibritumomab Tiuxetan in Relapsed or Refractory Primary Gastric Non Hodgkin Lymphoma." Blood 112, no. 11 (2008): 3063. http://dx.doi.org/10.1182/blood.v112.11.3063.3063.
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Abstract BACKGROUND: A prospective, single arm, open-label, phase II trial was performed to evaluate efficacy of 90Y-Ibritumomab Tiuxetan at conventional activity of 0,4 mCi/kg in Primary Gastric Non Hodgkin Lymphoma (NHL). PATIENTS AND METHODS: From May 2004 to May 2008, 13 patients affected by Primary Gastric NHL - either Mucosa Associated Lymphoid Tissue (MALT) or Diffuse Large B Cell (DLBC) NHL, relapsed/refractory disease - were enrolled to receive 90Y-Ibritumomab Tiuxetan at the activity of 0,4 mCi/kg. Median age was 57 ys (range 36–83), 6 female and 7 male. Nine out of 13 patients had gastric MALT NHL, the remaining 4 patients had DLBC NHL. At time of treatment 11 out of 13 patients had stage I/II, 2 patients had stage III/IV disease. Helicobacter Pylori was negative in all patients except one at time of treatment and positive at diagnosis in 5 of them. Median number of previous therapies received was 1 (1–4): all patients except 3 had received prior CT, 7 patients prior Rituximab, no one had received prior RT. RESULTS: Toxicities were primarily haematological and reversible. All patients had serial testing for HAMA and none developed antibodies to date. MALT-1 gene rearrangement was detected in 3 of the 9 cases analyzed, while none of the cases showed bcl-10 gene rearrangement. All patients are now evaluable for response: 10 out of 13 patients experienced a complete response (CR) (9 MALT, 1 DLBC); progressive disease (PD) was observed in 2 out of 13 patients, both DLBC NHL; finally another patient affected by DLBC NHL did not respond. After a median follow up of 24 months (range 3–50 months) 9 out of 10 CRs are disease free and 5 of them can be considered long term responders at 50, 43, 40, 32 and 31 months, respectively, following radioimmunotherapy (RIT). At the time of the analysis only 1 relapse occurred 17 months after RIT (MALT). Two patients - both DLBC - died due to disease progression. There was no statistically significant associations between response to RIT and the occurrence of the MALT-1 translocation. CONCLUSIONS: 90Y-Ibritumomab Tiuxetan seems to be very active in patients with primary gastric NHL relapsed or refractory to conventional systemic treatment, especially in gastric MALT NHL. Despite the relative short median follow-up (24 months), we observed durable long-term responses at least in 5 patients. High response rate and durable remissions could be related to the low tumor burden and consequently to higher absorbed doses to tumor, confirming the possible relationship between absorbed doses to tumor, efficacy and duration of response. If preliminary results can be confirmed in larger series, RIT could be offered as valid alternative approach in this setting because of its efficacy and low rate of side effects. These preliminary results warrant further studies.
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Tomas-Roca, Laura, Marta Rodriguez, Ruth Alonso-Alonso, Socorro M. Rodriguez-Pinilla, and Miguel Angel Piris. "Diffuse Large B-Cell Lymphoma: Recognition of Markers for Targeted Therapy." Hemato 2, no. 2 (2021): 281–304. http://dx.doi.org/10.3390/hemato2020017.
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Diffuse large B-cell lymphomas (DLBCL)s, the most common type of Non-Hodgkin’s Lymphoma, constitute a heterogeneous group of disorders including different disease sites, strikingly diverse molecular features and a profound variability in the clinical behavior. Molecular studies and clinical trials have partially revealed the underlying causes for this variability and have made possible the recognition of some molecular variants susceptible of specific therapeutic approaches. The main histogenetic groups include the germinal center, activated B cells, thymic B cells and terminally differentiated B cells, a basic scheme where the large majority of DLBCL cases can be ascribed. The nodal/extranodal origin, specific mutational changes and microenvironment peculiarities provide additional layers of complexity. Here, we summarize the status of the knowledge and make some specific proposals for addressing the future development of targeted therapy for DLBC cases.
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Bishop, M. R., R. M. Dean, S. Steinberg, et al. "Reduced-intensity allogeneic stem cell transplantation for diffuse large B-cell lymphoma: Clinical evidence of a graft-versus-lymphoma effect." Journal of Clinical Oncology 24, no. 18_suppl (2006): 6546. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.6546.
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6546 Background: Despite being the most common non-Hodgkin’s lymphoma, there have been no specific reports on the use of reduced-intensity (RI) allogeneic stem cell transplantation (alloSCT) to treat patients (pts) with diffuse large B-cell lymphomas (DBCL). This may be due to a lack of definitive evidence for a therapeutic graft-versus-lymphoma (GVL) effect against DLBC. We undertook a retrospective analysis to assess clinical outcomes and evidence of a GVL effect in DLBC pts undergoing RI alloSCT. Methods: The analysis was limited to 18 pts with primary refractory (n = 6) or relapsed (n = 12) DLBC. The median age was 43 years (range: 31–61); median number of previous treatments was 3 (range: 2–9). Nine (50%) pts had undergone autologous transplantation. Three (16%) pts were determined to have chemo-sensitive disease to last treatment prior to RI alloSCT. All pts received a RI conditioning regimen consisting of fludarabine (30 mg/m2/d × 4d) and cyclophosphamide (1200 mg/m2/d × 4d) followed by a T-cell replete allograft from HLA-matched siblings. Results: Median potential follow-up from transplant is 43 months. Seven (39%) pts developed grade II-IV acute GVHD. Response at day +100 post-transplant was as follows: complete response (CR/CRu) = 5; partial response = 5; progressive disease = 8. Nine of 17 (53%) evaluable pts developed chronic GVHD. Median progression-free survival (PFS) was 4.8 months; however, PFS after 9 months post-transplant was 31% with 5 pts in continuous CR/CRu > 12 months post-transplant. Among 14 pts who were not in CR/CRu (n = 12) or progressed after achieving a CR/CRu (n = 2) at day +100 post-transplant, 8 (57%) subsequently achieved a CR/CRu after removal of immune suppression and/or donor lymphocyte infusion (DLI) ± chemotherapy. Seven of these 8 pts remain in continuous (median = 34 months; range: 6–55+) CR/CRu without further treatment. Median survival for all 18 pts was 19 months with survival probability of 40% plateauing at 25 months post-transplant. Conclusions: The clinical observations of sustained CR/CRu after withdrawal of immune suppression and DLI suggest that a GVL effect exists against DLBC. RI alloSCT should be considered as a treatment option for pts with primary refractory and relapsed DLBC. No significant financial relationships to disclose.
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Vanazzi, Anna, Pier F. Ferrucci, Chiara Grana, et al. "Efficacy of 90Y-Ibritumomab Tiuxetan (Zevalin) in Refractory or Relapsed MALT Gastric Non Hodgkin’s Lymphoma." Blood 108, no. 11 (2006): 2771. http://dx.doi.org/10.1182/blood.v108.11.2771.2771.
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Abstract Radio-immunotherapy (RIT) is an effective approach for patients with relapse-refractory NHL. The aim of RIT is to use the monoclonal antibody to target radiation to the tumor bulk while limiting exposure of normal tissues. Toxicity is prevalently hematologic, but transient and reversible. Zevalin in particular has demonstrated activity in follicular (FL) and diffuse large B-cell (DLBC) NHL, but data are still lacking in MALT NHL. In this setting of pts Zevalin could offer an alternative option to those pts who relapse or do not respond to conventional treatment. We report efficacy results of a pilot study of Zevalin delivered at conventional activity (0,4 mCi/kg) in gastric NHL pts resistant or refractory to conventional systemic treatment. From May 2004 to January 2006, 7 patients were enrolled. They all had gastric resistant-refractory CD-20 positive B-cell NHL: 2 DLBC and 5 MALT. Median age was 57 ys (range 36–64), 3 female and 4 male. At time of treatment 5 out of 7 patients had stage I/IIA (MALT), while 2 out of 7 pts had stage III/IV (DLBCL) of disease. Helicobacter Pylori was negative in all pts at time of treatment, positive at diagnosis in 3 out of 5 pts affected by MALT gastric NHL. Median number of previous therapies received was 2 (1–4): all of them had received prior CT, 3 prior Rituximab, no one had received prior RT. Toxicities were primarily haematological, as expected, and reversible. Response evaluation was performed two months after Zevalin administration by upper gastrointestinal endoscopy with multiple biopsy and endoscopic ultrasonography. All patients are now evaluable for response: 5 CR (all MALT), 2 PD (both DLBC NHL). All responders still maintain a CR at 27, 20, 16, 9 and 8 months after treatment. Conclusions: Zevalin seems to be very active in pts with MALT gastric NHL resistant or refractory to conventional systemic treatment. Its mechanism of action mimics conventional RT already known as valid option in MALT gastric NHL. If these preliminary results are confirmed in larger number of pts, one single administration of Zevalin delivered at conventional activity (0,4 mCi/kg) could be considered a possible alternative option in the treatment of such indolent disease.
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Abdulhaq, Haifaa, and Maher Albitar. "Using Targeted RNA Next Generation Sequencing and Differential Expression to Compare Primary Central Nervous System Lymphoma with CD+ DLBCL, Nodal DLBCL and EBV+ DLBCL." Blood 136, Supplement 1 (2020): 22. http://dx.doi.org/10.1182/blood-2020-142235.
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Introduction:Primary central nervous system lymphoma (PCNSL) is a diffuse large B-cell lymphoma (DLBCL) with a tropism for the CNS microenvironment. Limited studies suggested differential expression of multiple extracellular matrix (ECM) and adhesions-related genes in PCNSL as compared to nodal DLBCL. We used next generation sequencing to evaluate expression profiles of 1408 genes and and performed differential expression profiling to compare PCNSL with nodal DLBCL, CD5+ DLBCL and EBV+ DLBCL. CD5+ DLBCL was selected because it is frequently ABC subtype. We also selected EBV+ DLBCL due to its poor outcome, similar to PCNSL. Methods:RNA was extracted from 30 formalin-fixed paraffin-embedded (FFPE) tissue samples from PCNSL patients and 23 FFPE tissue samples from cases with lymph node DLBCL-NOS, 8 samples CD5+DLBCL, 14 samples EBV+ DLBCL.. We sequenced the RNA using a 1408 gene panel (Illumina). Next Generation Sequencing was based on hybrid capture methodology. Total number of reads per sample must exceed 5 million to be accepted. RNA levels were quantified using FPKM. Levels of expression of each of the 1408 genes were compared between groups. The T-score is used to show differences. Considering the number of analyzed samples and to correct for multiple testing, only T-score less or greater than 3 was considered clinically significant. Results:PCNSL showed significant overexpression in 25 genes as compared with CD5+ DLBCL, while only 5 genes were highly expressed in PCNSL as compared with nodal DLBCL and 8 when compared with EBV+ DLBCL (Table below). Four genes were significantly less expressed in PCNSL as compared with CD5+ DLBCL, and only one gene when compared to nodal and EBV+ DLBCL. There was no significant difference in RNA expression of MYD88, CD79B, CARD11, KMT2D or SPP1 between PCNSL and DLBC-NOS, CD5+ DLBCL and EBV+ DLBCL . There was no significant difference between PCNSL and the other sub types in MYC, Ki67, BCL2, CD44, or CD274 (PD-L1) expression. Several genes emerged as highly expressed in PCNSL as compared with other subtypes of DLBCL (negative T-score). However, CLTC (Clathrin Heavy Chain) gene is uniquely highly overexpressed in PCNSL and not in any of the other 3 types of lymphoma. The CLTC gene is involved in anaplastic lymphoma as a partner gene for ALK (CLTC-ALK) in t(2,17) translocation. The SEPT2 (SEPTIN2) gene is uniquely highly expressed in PCNSL as compared with nodal and EBV DLBC lymphoma. SEPT2 gene plays significant role in Hodgkin lymphoma and in maintaining Reed-Stenberg cells . In contrast, VEGFC was significantly lower in PCNSL compared with nodal DLBCL. Conclusions:RNA molecular profiling suggests significant difference between PCNSL and CD5+ DLBCL and less difference when compared with nodal and EBV+ DLBCL. The strikingly high expression of CLTC gene in PCNSL suggests possible targeting of this gene might present a specific therapeutic approach for PCNSL. Figure Disclosures Abdulhaq: Novartis:Consultancy, Honoraria, Speakers Bureau;Astellas:Honoraria, Speakers Bureau;Amgen:Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau;Morphosys:Membership on an entity's Board of Directors or advisory committees, Research Funding;Oncopeptide:Research Funding.
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Laszlo, Daniele, Giancarlo Pruneri, Giovanna Andreola, et al. "Tissue Microarray (TMA) Study in DLBC Lymphomas (DLBCL): Could the Extranodal Origin Affect the Prognostic Impact of the Analysis?." Blood 108, no. 11 (2006): 2037. http://dx.doi.org/10.1182/blood.v108.11.2037.2037.
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Abstract DLBCL can be divided into two prognostically different subgroups, germinal center B-cell-like (GCB) and activated B-cell-like (ABC), according to twodifferent gene patterns identified with cDNA microarray technology. Though valuable, this technology is expensive and not generally available. However, the identification of individual antigens related to different stages of B-cell differentiation using immunohistochemistry, can be used to assess the two profiles yielding comparable results with respect to cDNA microarray technique. We have retrospectively investigated 105 patients (pts) diagnosed with de novo DLBCL and treated at our centre between November 2001 and June 2004; the only inclusion criteria was the availability of a tissue biopsy at diagnosis. Median age was 62 (19–85); stage at diagnosis was I–II in 49 pts (47%), III in 14 pts (13%) and IV in 42 pts (40%); according to IPI, 74 (70%) pts were defined as low (0–2) and 31 (30%) as high risk (3–5). Interestingly, the majority (53%) of our pts, had a primary extranodal lymphoma at diagnosis. TMA analysis was performed with antibodies to CD10, bcl-6 and MUM1 allowing the following classification: 50 pts (48%) were considered having CGB lymphoma and 55 pts (52%) having ABC disease. According to IPI risk score, 38 pts with CGB and 36 with ABC lymphoma were at low risk (0–2) whereas 10 with CGB and 16 with ABC lymphoma were at high risk (3–5). All pts received a median of 6 cycles of a CHOP-like, antracycline-based polychemotherapy. Observed ORR was 89% (94/105); 62 (59%) pts achieved a CR, 32 (30.5%) a PR while 11 (10.5%) failed to respond to treatment. Median follow-up of the surviving pts was 45 months ( 5–110). The 3-year OS for the entire group was 71% and the 3-year EFS was 54%. In terms of CR, PD and resistance to therapy, no difference was observed between the two TMA types of DLBCL. Pts obtaining a CR after 1st line treatment were equally distributed in both groups (28.6% in CGB vs 30.5% in ABC) as were those not responding to therapy (3.8% in CGB versus 6.7% in ABC). A separate analysis in pts with stage IV disease at diagnosis was also performed and showed similar results (40.5% of CR, 23.8% of NR; no difference was observed between the two TMA defined subgroups). Pts who experienced a PD at any time, were equally distributed between the 2 subgroups, either if they relapsed after first line therapy (6 pts in CGB group , 10 in the ABC one) or after any other subsequent treatment (12 in the CGB group, 18 in the ABC one). Furthermore, 39 of 56 (69%) patients with extranodal presentation at diagnosis showed a CR independently of their subgroup distribution (37.5% in the CGL group vs 32.1% in the ABC one), and pts experiencing a PR were equally distributed between the two groups. Our data do not support the use of TMA to predict outcome in DLBCL. However, previously published data supporting the prognostic impact of TMA, have not enrolled pts with lymphomas of primary extranodal origin which, instead, were the majority in our study. Indeed, the study by Colomo et al, which enrolled 39% of pts affected by extranodal lymphomas, also failed to demonstrate a role of TMA in predicting outcome in DLBCL pts. Furthermore, the use of a limited number of antigens to define different subtypes of DLBCL may not be sufficient to identify the same patterns as defined by cDNA microarray technology.
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Rujirojindakul, Pairaya, Kumpol Aiempanakit, Kanita Kayasut, Arnuparp Lekhakula, and Hutcha Sriplung. "No Prognostic Impact of p53 and P-Glycoprotein Expression in Patients with Diffuse Large B-Cell Lymphoma." ISRN Oncology 2011 (December 22, 2011): 1–6. http://dx.doi.org/10.5402/2011/670358.
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The aim of this study was to determine the clinical significances of p53 and p-glycoprotein (P-gp) expression on outcome predictors for patients with DLBC. We assessed the immunohistochemical expression of p53 and P-gp using formalin-fixed, paraffin-embedded specimens in 108 patients diagnosed with de novo DLBC. A high expression of p53 was found in 53.7% of the patients. No expression of P-gp was demonstrated in any of the specimens. There were no significant differences in the complete remission (CR) rate (P=0.79), overall survival (OS) (P=0.73), or disease-free survival (DFS) (P=31) between the p53-positive and p53-negative groups. The final model from multivariate analysis that revealed poor performance status was significantly associated with CR (P<0.001) and OS (P<0.001). Moreover, the advanced stage was a significant predictor of DFS (P=0.03). This study demonstrated no impact of the expression of p53 on either response or survival rates.
Dissertations / Theses on the topic "DLBC"
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Costa, Josiane Moreira da. "Acesso a terapia medicamentosa na perspectiva de pacientes e profissionais de saúde." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/DLCC-8ZUGRF.
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Case study with qualitative approach based on comprehensive sociology aiming at understanding the access to medications during pre, intra and post-hospitalization, according to perspectives from users and health professionals of a teaching hospital. The studys scenario is a large general teaching hospital that is reference in trauma, urgent care and emergency located at the North of Belo Horizonte. Seven patients,nine companions and 14 health professionals, a total of 30 participants, were the subjects determined by data saturation. Data was collected through interviews based on a semi-structured script for each segment. The data was submitted to content analysis and organized in four categories: 1. From the medications that I take to the ones I dont know: in the hands of health professionals; subdivided into two subcategories Patients (in) activity vs. professional tecnicism and Hospital admission and discharge as landmarks to the caring transition; 2. (Des) continuity ofdrug therapy; 3. Information as medications access strategy; 4. Possibleaccessibility. Results show that medications earn greater or lesser projection in the patients care besides being one of the strategies of health care in hospitalization. Thus, access to drug therapy becomes heterogeneous and permeated by values, relations and subjectivities provoking feelings based on the understanding of the need to medication use, fear of re-hospitalization, non-availability of drug therapy in the Primary Health Care Unities and the users inability to buy medication. Despite programs which offer medication supplies, access to them in the pre and posthospitalization periods is fragile constituting one of the factors which strengthen the patients cyclical walk in the health care net. The access barriers regarding information present themselves as a complex issue which involves different work processes permeated by both patient-professional relationships and interprofessional ones. However, information is essential to guarantee access to drug therapy in order to avoid compromising medication supplies, prescription and availability. Early discharge preparation, referencing mechanisms implantation and patients subjectivities acknowledgement are some of the activities which contribute to guarantee medication access. As a conclusion, drug therapy is built from relationships and experiences lived by the actors involved and reveals itself an important technology to caring in every level of health care.<br>Estudo de caso de abordagem qualitativa fundamentada na sociologia compreensiva com o objetivo de compreender o acesso a medicamentos nos momentos pré, intra e pós-internação hospitalar, segundo perspectivas dos usuários e profissionais de saúde de um hospital de ensino. O cenário de estudo foi um hospital de ensinogeral, de grande porte e referência em trauma, urgência e emergência, localizado na região norte do município de Belo Horizonte. Os sujeitos foram sete pacientes, nove acompanhantes e 14 profissionais de saúde, em um total de 30 participantes, determinados por saturação de dados. A coleta de dados foi por meio de entrevistas a partir de um roteiro semiestruturado para cada segmento. Os dados foram submetidos à análise de conteúdo e organizados em quatro categorias: 1. Dos remédios que tomo aos que não sei: nas mãos dos profissionais de saúde; subdividida em duas subcategorias - A (in)atividade do paciente versus o tecnicismo profissional e A admissão e alta hospitalar como marcos na transição do cuidado; 2. A (des)continuidade da farmacoterapia; 3. Informação como estratégia de acesso aos medicamentos; 4. Acessibilidade possível. Os resultados mostram que os medicamentos ganham maior ou menor projeção nos cuidados ao paciente, além de serem uma das estratégias de atenção à saúde na hospitalização. Por isso, o acesso à farmacoterapia se torna heterogêneo, permeado de valores, relações e subjetividades, provocando sentimentos pautados no entendimento da necessidadedo uso dos medicamentos, do medo da reinternação, da indisponibilidade da farmacoterapia nas Unidades de Atenção Primária à Saúde e da incapacidade de compra de medicamentos pelo usuário. Apesar de programas que ofereçam abastecimento de medicamentos, o acesso a estes nos períodos pré e pós-internação se mostra fragilizado, constituindo-se um dos fatores fortalecedores do caminhar cíclico do paciente na rede de cuidados. As barreiras ao acesso referentes à informação se apresentam como um tema complexo, o que envolvediferentes processos de trabalhos permeados tanto pela relação profissional paciente como pelas interprofissionais. Entretanto, a informação é essencial para garantia do acesso à farmacoterapia, a fim de se evitarem comprometimentos de abastecimento, prescrição e disponibilidade dos medicamentos. Preparação da alta com antecedência, implantação de mecanismos de referenciamento ereconhecimento das subjetividades dos pacientes são algumas ações que contribuem para a garantia do acesso aos medicamentos. Conclui-se que a farmacoterapia é construída a partir das relações e vivências dos atores envolvidos e se revela importante tecnologia para o cuidado em todos os níveis de atenção à saúde.
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Wong, Chun-ming, and 黃俊銘. "Characterization of novel tumor suppressor genes, DLC-1 and DLC-2, in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27768533.
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Graupner, Karola. "Untersuchungen zur Hochrateabscheidung harter DLC-Schichten." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11679790.
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Salgueiredo, Ermelinda da Conceição Portela. "Filmes de DLC para aplicações biotribológicas." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/2248.
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Mestrado em Engenharia Biomédica - Biomateriais<br>Os filmes de carbono amorfo tipo diamante (DLC) actuam como lubrificantes
sólidos em muitas aplicações de desgaste incluindo os implantes articulares da
anca e joelho. Entre estes, os filmes de carbono não-hidrogenado podem ser
depositados pela técnica de deposição física em fase vapor (PVD) a baixas
temperaturas (<325ºC). Estes filmes protectores são quimicamente inertes,
possuem elevada dureza e baixo coeficiente de atrito contra polietileno de ultra
alto peso molecular (UHMWPE) e outros biomateriais, aumentando assim a
qualidade dos implantes articulares.
Filmes de DLC foram depositados por sputtering DC em substratos à base de
nitreto de silício (Si3N4 monolítico; compósitos Si3N4/TiN e Si3N4/bioglass)
visando elevados níveis de adesão. A nanoestrutura do DLC, confirmada pela
fraca intensidade da banda D do espectro Raman, combinada com o elevado
conteúdo de ligações sp3, comprovado pelo desvio da banda G, levou a um
valor de dureza de 16 GPa. Os filmes apresentam-se densos e homogéneos
com um valor extremamente baixo de rugosidade (RMS=2.6 nm).
Antes de ser implantado no corpo humano, um material tem de provar ser
biocompatível. Antes da deposição de DLC, os substratos foram recobertos
com uma camada de Si para promover a adesão. Após 35 dias de imersão em
SBF, a observação SEM demonstrou que não ocorreu formação de camada
apatítica na superfície. A análise química por ICP-AES mostrou que não houve
variação na concentração dos iões Ca e P, e que não foram libertados
elementos tóxicos na solução. A hidrofobicidade, tensão superficial e carga
superficial deste biomaterial foram também avaliadas. A superfície apresentou
um valor ligeiramente negativo de carga, como demonstrado pelo valor do
potencial zeta de -35.0 ± 1.3 mV para pH=7.4 ± 0.2. A tensão superficial foi de
45.7 mN/m, apresentando uma componente dispersiva predominante da
tensão superficial. Os resultados mostram que o revestimento de DLC é
tendencialmente hidrofóbico. Os estudos com a linha celular de osteoblastos
humanos MG63 não revelaram indícios de citotoxicidade. As células
apresentaram morfologia normal e maior crescimento celular, quando
comparadas com as placas standard de cultura, mostrando, no entanto, menor
adesão celular.
Para os ensaios biotribológicos, bolas e discos cerâmicos foram recobertos
com filmes de DLC numa primeira etapa para ensaios de deslizamento a seco
em movimento recíproco, com pares próprios. Um bias negativo foi aplicado ao
compósito condutor Si3N4/TiN, resultando em valores de coeficiente de atrito
extremamente baixos(μ=0.015). Numa segunda etapa, placas recobertas com
DLC foram testadas contra bolas de UHMWPE. Os testes foram efectuados a
seco e lubrificado (SBF). Os resultados preliminares mostram que o coeficiente
de atrito mantém-se constante ao longo do ensaio, sem delaminação do DLC.
Estes resultados favoráveis permitem recomendar o Si3N4 revestido com DLC
como adequado para aplicações em próteses articulares.
ABSTRACT: Diamond-like carbon (DLC) films act as solid-film lubricants in many wear
resistant applications including articulated implants as hip and knee joints.
Among these, non-hydrogenated amorphous carbon films can be grown by
Physical Vapour Deposition (PVD) technique at low deposition temperatures
(<325ºC). These protective coatings possess chemical inertness, high
hardness and low friction coefficient against Ultra High Molecular Weight
Polyethylene (UHMWPE) and other biomaterials, thereby improving the quality
of articulated implants.
In this study, the DLC films were deposited by DC magnetron sputtering over
silicon nitride based substrates (bulk Si3N4; Si3N4/TiN and Si3N4/bioglass
composites) aiming high adhesion levels. DLC nanostructure, confirmed by the
weak intensity of the Raman spectra D band position, combined with significant
sp3 content, as depicted by the G band downshift, lead to a hardness value of
about 16 GPa. Films are dense and homogeneous in all the deposited area
with an extremely low roughness of 2.6 nm (RMS).
Before implantation in the human body, a material must prove to be
biocompatible. Prior to the DLC deposition, the Si3N4 based ceramics were
coated with a Si interlayer to promote adhesion. After 35 days of immersion in
Simulated Body Fluid, SBF, the DLC surface showed no signs of apatite layer
formation, as observed by SEM. Also, ICP-AES analysis confirmed no variation
of the Ca and P ions concentration levels, and no toxic elements released into
solution were detected. Hydrophobicity, surface tension and surface charge
was also evaluated. The DLC surface is slightly negative charged, has shown
by the zeta potential value of -35.0 ± 1.3 mV at pH=7.4 ± 0.2. The surface
tension of the DLC coated samples was 45.7mN/m, presenting a dominant
dispersive component of the surface tension. Results showed that the DLC
coating is quite hydrophobic. Using the MG63 osteoblast-like cells, no evidence
of citotoxicity was observed. Cells showed normal morphology and higher cell
growth, compared to standard culture plates, although with low cell adhesion.
For biotribological assessment, in a first stage Si3N4 ceramic balls and discs
were coated with DLC films for self-mated reciprocating dry sliding tests. A
negative bias voltage applied to a conductive Si3N4/TiN composite showed a
remarkable improvement under the same tribological solicitation, presenting
very low friction coefficient values (μ=0.015) during the full duration of the test.
In a second stage, DLC-coated Si3N4 ceramics were tested against UHMWPE
spheres using a reciprocating ball-on-flat set-up. The sliding occurred under dry
and lubricated (SBF) conditions. Preliminary results showed that the friction
coefficient is almost constant during the running-in period without delamination
of the DLC coating.
Based in these favourable results, the DLC-coated Si3N4 biomaterial seems
adequate to be used for articular prosthesis development.
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Rudolf, Miroslav. "Depozice a analýza tenkých vrstev DLC." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2009. http://www.nusl.cz/ntk/nusl-228535.
Full textAbstract:
Diplomová práce nastiňuje problémy spojené s výrobou a analýzou tenkých vrstev DLC:H. Tyto vrstvy jsou ve středu zájmu mnoha vědeckých pracovníků již po několik desetiletí. V současné době existuje mnoho technik pro přípravu a analýzu. Příprava DLC vrstev má zásadní vliv na jejich vlastnosti a možnosti použití. Je zde mnoho kritérií jak vrstvy posuzovat. V této práci jsou studovány vlastnosti DLC:H vrstev připravených na substrát krystalického křemíku metodou RF-PECVD a následně jsou studovány mechanické, tribologické a optické vlastnosti. Jsou zde využity techniky jako XPS, Ramanova spektroskopie, reflektometrie, měření tvrdosti a adheze. Část práce se zabývá modelováním DLC z prvních principů. Pro tento účel je využito prvoprincipiálního programu Abinit který je šířen pod GPL. Je studována otázka přípravy vstupních dat s ohledem na konvergenci výsledků. Pozornost je také věnována výpočtu vibračních spekter ve středu Brillouinovy zóny ( bod) a celkové hustotě elektronových stavů clusteru DLC v supercele tvaru krychle. Tyto výsledky mohou být porovnány s experimentálně získanými daty z Ramanovy spektroskopie, respektive z XPS spektra valenčního pásu
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Marek, Mojmír. "Optimalizace distribučních cest - DLC Napajedla, a.s." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-2882.
Full textAbstract:
Práce má za úkol nastínit možné směry optimalizace rozvrhu distribučních cest. Nástrojem je vhodně konstruovaný model, který se stane součástí aplikace. Aplikace vychází z programů MS Excel a LINGO. Zadání a následné řešení práce má podobu projektu. Předmětem není pouze vytvořit statický model (aplikaci). Práce také vychází z připomínek a požadavků zadavatele.
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Vengudusamy, Balasubramaniam. "Behaviour of lubricant additives on DLC coatings." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/11734.
Full textAbstract:
Non-ferrous surfaces such as diamond-like carbon (DLC) coatings are becoming potential candidates for automotive engine parts because of fuel economy gains that these surfaces offer by operating with very low friction. In recent years, a wide range of DLC coatings have been developed and it is important to understand their film-forming, friction reduction and wear resistance mechanisms under lubricated conditions. This aim of the work described in this thesis is to improve our understanding of the tribological behaviour of DLC coatings with different engine oil additives. The main focus of the thesis is to study a wide range of available DLC coating types with currently available and widely-used additives such as ZDDP, friction modifiers, MoDTC etc., in order to establish general rules of their tribological behaviour that will help lubricant manufacturers produce new oil formulations. The research shows that tribofilms are formed on all DLCs by most of the currently used additives and that the film thickness depends on various factors such as type of DLC coating, doping elements present in the coatings, concentration of hydrogen and tungsten present in the coatings and the counterpart. Hydrogen-free coatings (a-C and ta-C) give lower boundary friction compared to the other coatings whereas hydrogenated amorphous carbon (a-C:H) coatings give better wear resistance properties. Study of a-C:H:W coatings shows that the concentration of tungsten present in the coatings has a significant influence on wear resistance properties but negligible influence on the friction properties when additives are present. The steel/steel couple is known to form a thick ZDDP tribofilm. If one of the contact surfaces is coated with DLC, the tribofilm forming properties on the steel vary and, for some cases, the low boundary friction properties of DLCs are degraded.
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Silva, Cruz Ricardo Manuel Santos da. "TiBâ‚‚ ceramic and DLC multilayered PVD coatings." Thesis, Cranfield University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443347.
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Santos, da Silva Cruz Ricardo Manuel. "TiB2 ceramic and DLC multilayered PVD coatings." Thesis, Cranfield University, 2007. http://dspace.lib.cranfield.ac.uk/handle/1826/1863.
Full textAbstract:
Titanium diboride (TiB2) has been investigated as a potential candidate for several industrial applications, such as: cutting tools, electric devices, wear parts and many more fields of application. The main drawback of TiB2 is its brittle nature, which has limited its range of applications. Diamond-like Carbon (DLC) has been used in industrial applications, mainly for wear resistant parts. However, the application of DLC films has been limited by the level of internal stress accumulated during deposition. This thesis investigates the deposition of TiB2/DLC multilayer wear resistant coatings to overcome these limitations. The thesis focuses on the tribological effects caused by different deposition techniques on TiB2 ceramic used by the coatings industry today, in order to overcome the brittle nature of TiB2 and the lack of adhesion of DLC films. The multilayer coatings consisted of 25 bi-layers of TiB2/DLC. These TiB2/DLC coatings were fabricated, maintaining a constant composition wavelength (sum of two layers λ =200 nm) for an array of ceramic fractions ranging from 25% to 95% by volume using as substrates, tool steel AISI 1095 and powder metallurgy aluminium alloys, type 2618. The effect of the DLC content on the structure and performance (hardness, adhesion and wear) of the films was investigated. The bi-layer thickness influences the failure patterns observed in the scratch testing. These observations have been used to optimise the multilayered coating structure. Multilayer coatings have been manufactured to increase surface hardness and wear resistance as applied to a commercial powder metallurgy Al alloys (Al 2618) used in the automotive industry. Optimum coatings have found hardness values of 27.8 GPa, with a critical load of 20 N and a friction coefficient of 0.47. As a result of wear tests the multilayer with 10% of DLC was found to be best compromise between high hardness (23.8 GPa), good adhesion (critical load higher than 20 N), low friction and low wear rate.
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Rizzo, Vinícius Zacarias. "Estudo das propriedades ópticas e eletro-ópticas de filmes de carbono amorfo tipo diamante - DLC." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/3/3140/tde-10012011-143459/.
Full textAbstract:
Neste trabalho foram estudadas as características elétricas e ópticas de filmes de carbono tipo diamante (DLC Diamond-Like Carbon) depositados em um sistema de sputtering RF magnetron reativo em substratos de silício e vidro. Foram depositadas amostras em condições de processo distintas em cada tipo de substrato, sendo duas condições de pressão (5 mTorr e 10 mTorr) e para cada uma, quatro condições de potência de RF (100 W, 150 W, 200 W e 250 W). Os filmes depositados foram submetidos às seguintes técnicas de caracterização: perfilometria, para obtenção da espessura dos filmes e com isso a taxa de deposição; elipsometria, para obtenção do índice de refração; obtenção de curvas I-V, para obtenção da resistividade elétrica e cálculo do ganho de foto corrente, e da curva C-V de alta frequência, para cálculo da constante dielétrica dos filmes; transmitância óptica, para o cálculo do gap óptico através do método de Tauc; fotoluminescência, para determinar a emissão característica deste gap e espectroscopia de infravermelho por transformada de Fourier (FTIR), para se observar os tipos de ligações presentes no filme e calcular a relação entre hibridizações sp3 e sp2 entre átomos de carbono e hidrogênio no filme. As variações de algumas características dos filmes de DLC com os parâmetros de processo são apresentadas e comparadas. De acordo com as características dos filmes obtidos neste trabalho, com a variação dos parâmetros de processo, é possível sua aplicação como dielétrico de campo, por apresentarem baixa constante dielétrica, sendo o valor mais baixo obtido igual a 3,4; como material dielétrico de porta considerando os filmes com alta constante dielétrica, chegando a 6,7; como material para cobertura, devido à alta uniformidade (até 95%); e, o que foi mais explorado neste trabalho, para aplicações como sensores foto sensíveis, sendo que o maior ganho de foto corrente obtido foi 67 vezes. A possibilidade de produção de filmes de DLC com diferentes propriedades através da variação das condições de processo mostra sua versatilidade para uso em diferentes aplicações.<br>In this work it was studied electrical and optical characteristics of diamond-like carbon (DLC) films deposited in a reactive RF magnetron sputtering system on silicon and glass substrates. Samples were deposited at different process conditions in each type of substrate at two pressure conditions (5 mTorr and 10 mTorr) and four conditions of RF power (100 W, 150 W, 200 W and 250 W). The DLC films were characterized by the following techniques: high step meter analysis, to obtain the thickness of the films and thus the deposition rate; Ellipsometry to obtain the refractive index; electrical characterization by the I-V curve, to obtain the resistivity and calculate the photo current gain, and high-frequency C-V curve, to calculate the dielectric constant of the films; optical transmittance, to calculate the optical gap by the Tauc method; photoluminescence analysis, to determine the characteristic emission of this gap; Fourier transform infrared spectroscopy (FTIR), to observe the different carbon-hydrogen bonds and calculate its sp3/sp2 hybridizations ratio. The way some characteristics of DLC films vary with the process parameters are presented and compared in this work. According to the characteristics of the DLC films obtained in this work, with the variation of the process parameters it is possible their application as low k dielectric insulators, because of its low dielectric constant, being the lowest obtained value 3.4; as dielectric gate material, reaching 6.7 in the films deposited in this work, as coating material due to its high uniformity (95%), and which was further explored in this work, for applications like photo-sensitive sensors, since it was obtained samples with photo current gain up to 65. The possibility of producing DLC films with different properties by varying process parameters shows its versatility for using in different applications.
Books on the topic "DLBC"
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Crawford, Richard I. Novel routes to DLC and related wear coatings. The Author], 1998.
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DLC-1,000+: Delicious low cholesterol-1,000 calories or more. ARCHWAY PUBLISHING, 2014.
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Miyoshi, Kazuhisa. CVD diamond, DLC, and c-BN coatings for solid film lubrication. National Aeronautics and Space Administration, Lewis Research Center, 1998.
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Miyoshi, Kazuhisa. CVD diamond, DLC, and c-BN coatings for solid film lubrication. National Aeronautics and Space Administration, Lewis Research Center, 1998.
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G, Isaac Martinez. Conductivity and hall effect in diamond-like carbon (DLC) thin films. National Library of Canada, 2003.
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Russia) Obshcherossiĭskiĭ seminar po diodnoĭ lazernoĭ spektroskopii im. A.M. Prokhorova (17th 2012 Moscow. 17-yĭ obshcherossiĭskiĭ seminar po diodnoĭ lazernoĭ spektroskopii im. A.M. Prokhorova (DLC-17), Moskva, 28 marta 2012 = The 17th A.M. Prokhorov All-Russian seminar on tunable diode laser spectroscopy (TDLS-17), Moscow, 28 March 2012. [publisher not identified], 2012.
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9
Erkol, Cimen Gunay, and Burcu Alkan. DLB 379: Turkish Novelist, Second Series. Gale Research Inc, 2016.
Find full textBook chapters on the topic "DLBC"
1
Metze, Dieter, Tam Nguyen, Birgit Haack, et al. "DLBD." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8337.
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Simola, Nicola, Micaela Morelli, Tooru Mizuno, et al. "DLB." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4206.
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Metze, Dieter, Tam Nguyen, Birgit Haack, et al. "DLB." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8340.
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Zhong, Hao, and Shimon Y. Nof. "The DLOC Model." In Automation, Collaboration, & E-Services. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-34463-4_3.
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Zhong, Hao, and Shimon Y. Nof. "The TIE/DLOC Tool." In Automation, Collaboration, & E-Services. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-34463-4_5.
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Tanaka, Mieko, Toshimitsu Musha, Yohei Kobayashi, Haruyasu Matsuzaki, and Yukio Kosugi. "Electroencephalography in DLB." In Dementia with Lewy Bodies. Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55948-1_14.
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Lo Bianco, Joseph. "Quo Vadis, DLC?" In Dominant Language Constellations. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52336-7_13.
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Mheidly, Kayane, Roch Houot, Michael Scordo, and Craig Moskowitz. "Standard of Care Relapsed DLBCL." In Künstliche Photosynthese. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-030-00362-3_6.
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Ivanov-Omskii, V. I. "Copper Nanoclusters in DLC." In Diamond Based Composites. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5592-2_13.
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Argus, Don, and Danny Samson. "Attachment 1: BHP DLC." In Strategic Leadership for Business Value Creation. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9430-4_18.
Full textConference papers on the topic "DLBC"
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Zhang, Chuanwei, Le Gu, and Dezhi Zheng. "Tribological Property Analyses of DLC Films on Ceramic Ball Surfaces With 3-D FEA Method and Experiments." In ASME/STLE 2012 International Joint Tribology Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/ijtc2012-61068.
Full textAbstract:
Diamond-like carbon (DLC) films are excellent candidates to improve tribological properties of silicon nitride (Si3N4) ceramic elements. Particular attentions have been paid to the preparation and analysis of DLC films on rings and discs. However, few researches on fabrication of DLC films on ball surfaces were carried out, especially on ceramic ball surfaces, because it is hard to achieve uniform coatings on ball surfaces. In this paper, DLC films on ceramic ball surfaces were studied with both experiment and FEA method. DLC films were deposited on Si3N4 ceramic ball and disc surfaces with plasma immersion ion implantation and deposition techniques (PIII-D). Surface topography of ceramic balls before and after coated with DLC films showed that DLC films on ceramic ball surfaces were uniform. Tribological tests under dry friction were conducted with a ceramic ball sliding against ceramic disc and, alternatively, one of the two surfaces was coated with DLC films. The tests demonstrated that DLC films on disc surfaces were worn, while ball surface films were partly flaked. 3-D FEA models of ceramic ball sliding against ceramic disc were built and the ceramic ball/disc was coated with DLC films alternatively. DLC films were supposed to be bonded with ceramic substrates. The FEA stress fields in DLC films and on film/substrate interface showed that DLC films had great effects on stress distribution due to the low frictional coefficient and material difference from substrates. The friction force caused an increment of the stress near surfaces during sliding process, and the material difference leaded to discontinuous stress distribution on film/substrate interface. The shear stress on film/substrate interface was very slightly different between DLC films coated on ceramic balls and discs. Under almost the same shear stress, the flakes and wear of DLC films were mainly determined on the adherence of DLC films to ceramic substrates.
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Chu, Chi-Min, Tai-Lang Jong, and Yue-Wei Huang. "Mitigating DLC Constraints of Air-conditioning Loads Using a group-DLC Method." In 2007 IEEE Power Engineering Society General Meeting. IEEE, 2007. http://dx.doi.org/10.1109/pes.2007.385626.
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Topolovec-Miklozic, Ksenija, T. Reg Forbus, Frances Lockwood, and Hugh Spikes. "Behaviour of Boundary Lubricating Additives on DLC Coatings." In ASME/STLE 2007 International Joint Tribology Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ijtc2007-44485.
Full textAbstract:
The friction properties of a range of boundary lubricating additives in DLC-DLC sliding-rolling, lubricated contact have been investigated. Two types of DLC have been studied, one hydrogenated diamond-like and the other a non-hydrogenated graphitic type. The graphitic-type DLC coating gave initially very low boundary friction with additive-free base oil but after a few minutes of rubbing in thin film conditions this rose to the higher value produced immediately by the diamond-like DLC. With the graphitic-type DLC, ZDDP formed a thin patchy film while MoDTC produced a marked reduction of friction. Lateral force microscopy showed that the latter resulted from the formation of low friction material on the asperity peaks. Some organic friction modifiers preserved the low friction of g-DLC during prolonged rubbing. MoDTC and ZDDP were also effective in reducing friction on diamond-like DLC.
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Narayan, R. J. "Novel Nanostructural Biomaterial Composites." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-39374.
Full textAbstract:
Hydrogen-free diamondlike carbon (DLC), with hardness values close to that of diamond, possess many desirable biocompatible properties for a variety of biomedical applications. The DLC coatings can be applied to joints prostheses, heart valves, and other medical devices. Unfortunately, hydrogen-free DLC coatings have a large compressive stresses which result in poor adhesion and wear characteristics. In this paper, we present results on silver doping of DLC to alleviate internal stresses as well as create DLC-Ag nanocomposites where Ag is in the form of nanoparticles. The Ag nanoparticles are expected to impart antimicrobial properties by providing sources of electrons. In the second part of the paper, we have created DLC and nanotube composites where nanotubes grow normal to the surface. This novel architecture not only alleviates internal stresses, but DLC + Nanotube composites have enhanced hardness and unique antimicrobial properties. Finally, we discuss novel multilayer DLC and hydroxyapatite (HA) composite where HA and DLC films are deposited sequentially at room temperature. The HA films with composites close to that of bone is considered very desirable for biocompatibility and integration with base structures. We discuss novel processing, characterization, hardness and bioeompatible properties of all these composites in detail.
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Rezaei, V., and A. M. Shafei. "Determination of DLCC for Elastic Robotic Manipulators." In 2018 6th RSI International Conference on Robotics and Mechatronics (IcRoM). IEEE, 2018. http://dx.doi.org/10.1109/icrom.2018.8657526.
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McCord, Ron, Megan Field, Philip Jordan, Ewan Hunter, Alexandre Akoulitchev, and Kirsten E. Mundt. "Abstract 462: Chromatin signatures of DLBCL subtypes." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-462.
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Tani, Hiroshi, Renguo Lu, Shinji Koganezawa, and Norio Tagawa. "Investigation of Smear Formation Mechanism From DLC Film by Heating." In ASME 2020 29th Conference on Information Storage and Processing Systems. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/isps2020-1902.
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Abstract The formation of head smear from DLC films on magnetic disks was confirmed by a simulated heating experiment. DLC films of 100-nm thickness were prepared and heated on a hot plate in an environmental gas chamber. Smear on a silicon wafer placed 3 mm above the DLC surface was observed after heating of the DLC film. The smear amount was quantified using the carbon intensity of the smear measured by XPS. In air, the carbon concentration decreased with the heating temperature; however, the carbon concentration increased with temperature in nitrogen. The carbon concentration of the smear in the air environment was smaller than that of nitrogen. As the result of comparison of smears on DLCs with various hydrogen concentrations, more decomposed gas is generated from the DLC film as the amount of hydrogen contained in the DLC increases, and this value increases at lower temperatures. This result suggests that DLC films with low hydrogen concentrations generate a smaller amount of decomposition gas than those with high hydrogen concentrations during heating. In addition, Raman spectra suggest that the DLC degraded by heating and the hydrocarbon gas-like materials were generated from the DLC film because the DLC films include carbon and hydrogen. Because fragments of 250–500 atomic mass units were observed in the TOF-SIMS spectra of smears, the smear is estimated to consist of a hydrocarbon of relatively high molecular weight.
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Papke, B. L., and P. P. Parthasarathy. "Tribological Film Formation on Hydrogenated DLC/Steel Contacts From Fully Formulated Automotive Lubricants." In ASME/STLE 2009 International Joint Tribology Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/ijtc2009-15157.
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Tribological film formation from fully-formulated synthetic automotive lubricants on hydrogenated DLC/steel contacts was compared with that on steel/steel contacts. Four DLC coatings containing various metal dopants (W and Si) were evaluated. Lubricants formulated with organic friction modifiers performed better on DLC/steel than on steel/steel in both sliding and rolling/sliding contacts (lower friction and wear). In contrast, lubricants formulated with MoDTC friction modifiers had higher sliding contact friction on DLC/steel than on steel/steel. No evidence was observed for tribological film formation on the DLC surfaces.
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Choi, Jonghak, Kyoung-Su Park, Geonyup Lim, No-Cheol Park, and Young-Pil Park. "A Flying Stability of the Slider With Damaged DLC Layer by Confined Optical Energy in TAMR System." In ASME 2014 Conference on Information Storage and Processing Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/isps2014-6961.
Full textAbstract:
This research investigates to analyze the effect of laser of thermally assisted magnetic recording system on diamond like carbon (DLC) layer of slider. We investigated a damaged DLC layer of slider with laser spot-induced damage and analyze the effect of the damaged DLC layer in slider dynamics. The damaged DLC layer resulted in change of flying height and air bearing stiffness pressure.
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Maeda, Fukuo, and Yasunori Iwai. "Prediction Model of NOx for Gas Turbine Combustor With Diffusion and Lean Premixed Flames." In ASME 1995 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/95-gt-169.
Full textAbstract:
In order to predict the NOx concentration etc., it is necessary to carry out 3-D reacting flow analysis in the combustion zone. However, regardless of improved numerical scheme, and physics-based modeling of flow phenomena and combustion reaction, these techniques not yet reached to a level to be applied to practical combustor problem, because of vast computation time and consequently high computation costs, etc. To improve NOx characterization of new Dry Low NOx Combustor (DLNC) and optimum fuel scheduling for DLNC operations, a NOx prediction method to be applicable for practical combustor problems needs to be developed. In this paper has been proposed a simple semi-empirical model for predicting DLNC NOx emissions that formed from lean premixed combustion flames and diffusion flames. This model comprised of experimental coefficients for adjusting or incorporating effects of practical combustion liner configurations and effects of flow conditions in combustion zone, etc. Also, the present model is applied to newly designed and redesigned DLNC for estimating NOx emission levels and its variation with gas turbine operating conditions, which are compared with the experimental data of full pressure combustion with Natural Gas (NG) fuel.
Reports on the topic "DLBC"
1
Hamada, Takahiro, Yutaka Mabuchi, Makoto Kano, et al. Development of DLC Valve Lifter. SAE International, 2005. http://dx.doi.org/10.4271/2005-08-0003.
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Liu, Y., A. Erdemir, and E. I. Meletis. Influence of environmental parameters on the frictional behavior of DLC coatings. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/634091.
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Walter, K. C., H. Kung, and T. Levine. Characterization and performance of DLC films synthesized by plasma and ion beam techniques. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/10182138.
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Ando, Junji, Toshiyuki Saito, Naoyuki Sakai, et al. Development of Compact, High Capacity 4WD Coupling With DLC-Si-Coated Electromagnetic Clutch. SAE International, 2005. http://dx.doi.org/10.4271/2005-08-0033.
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Miles, Edward F., Luke Balsamo, David B. Turton, and William Graf. Recurrent PET FDG Uptake after Sequential Chemotherapy and Radiation Therapy for DLBCL of the Tibia: A Case Report and Review of the Literature. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada552075.
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Fountzoulas, Costas G., John D. Demaree, Louis C. Sengupta, James K. Hirvonen, and Dimitar Dimitrov. Wear and Tribological Properties of Silicon-Containing Diamond-Like Carbon (Si-DLC) Coatings Synthesized with Nitrogen, Argon Plus Nitrogen, and Argon Ion Beams. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada347548.
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