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Journal articles on the topic 'Dlomo'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Swanson, L., J. Arnedt, K. DuBuc, T. de Sibour, and H. Burgess. "0039 The Clinical Utility of Dim Light Melatonin Onset in Treatment of Delayed Sleep-Wake Phase Disorder: Preliminary Findings." Sleep 43, Supplement_1 (2020): A16. http://dx.doi.org/10.1093/sleep/zsaa056.038.

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Abstract Introduction Delayed sleep-wake phase disorder (DSWPD) is common, debilitating, and challenging to treat. In an ongoing randomized trial, we are comparing exogenous melatonin treatment outcomes in DSWPD participants for whom dim light melatonin onset (DLMO) is measured objectively vs. estimated. Methods Thus far, 13 participants (27±6 years old, 67% female) have completed a randomized, controlled, double-blind 4-week trial of 0.5 mg of exogenous melatonin timed to either 3 h before measured DLMO (M-DLMO, n = 6) or 3 h before DLMO estimated at 2 h before average sleep onset time based

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2

Grant, Dwight. "Thoughts on Calculating DLOMs." Business Valuation Review 33, no. 4 (2014): 102–12. http://dx.doi.org/10.5791/0882-2875-33.4.102.

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3

LaRosa, K. N., S. J. Crowley, D. Hancock, et al. "0994 Assessment Of Sleep-wake And Circadian Rhythm Disruption In Children And Adolescents Diagnosed With Craniopharyngioma." Sleep 43, Supplement_1 (2020): A377—A378. http://dx.doi.org/10.1093/sleep/zsaa056.990.

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Abstract Introduction Patients with craniopharyngioma are at increased risk for hypersomnia/narcolepsy and circadian rhythm disruption, secondary to hypothalamic-pituitary involvement of the tumor. We assessed youth with craniopharyngioma to determine presence of the dim light melatonin onset (DLMO) and concurrent sleep disturbance. Methods Fifty-two patients (7-21 years; 51% female) enrolled on our institutional protocol for craniopharyngioma that included surgery, proton therapy, or both. In-home salivary melatonin was collected after surgery and hourly beginning 3 h before to 1 h after habi

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4

Shoresh, Michal, Sara Orgad, Orit Shmueli, et al. "Overexpression Beadex Mutations and Loss-of-Function heldup-a Mutations in Drosophila Affect the 3′ Regulatory and Coding Components, Respectively, of the Dlmo Gene." Genetics 150, no. 1 (1998): 283–99. http://dx.doi.org/10.1093/genetics/150.1.283.

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Abstract LIM domains function as bridging modules between different members of multiprotein complexes. We report the cloning of a LIM-containing gene from Drosophila, termed Dlmo, which is highly homologous to the vertebrate LIM-only (LMO) genes. The 3′ untranslated (UTR) of Dlmo contains multiple motifs implicated in negative post-transcriptional regulation, including AT-rich elements and Brd-like boxes. Dlmo resides in polytene band 17C1-2, where Beadex (Bx) and heldup-a (hdp-a) mutations map. We demonstrate that Bx mutations disrupt the 3′UTR of Dlmo, and thereby abrogate the putative negat

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Reiter, Andrew M., Charli Sargent, and Gregory D. Roach. "Concordance of Chronotype Categorisations Based on Dim Light Melatonin Onset, the Morningness-Eveningness Questionnaire, and the Munich Chronotype Questionnaire." Clocks & Sleep 3, no. 2 (2021): 342–50. http://dx.doi.org/10.3390/clockssleep3020021.

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Chronotype reflects circadian timing and can be determined from biological markers (e.g., dim light melatonin onset; DLMO), or questionnaires (e.g., Morningness-Eveningness Questionnaire; MEQ, or Munich Chronotype Questionnaire; MCTQ). The study’s aim was to quantify concordance between chronotype categorisations based on these measures. A total of 72 (36f) young, healthy adults completed the MEQ and MCTQ and provided saliva samples hourly in dim light during the evening in a laboratory. The corrected midpoint of sleep on free days (MSFsc) was derived from MCTQ, and tertile splits were used to

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6

Crowley, S. J., K. Janevski, and C. I. Eastman. "0339 Where Does the Time Go? Reported Activities Around the DLMO in Older Adolescents." Sleep 43, Supplement_1 (2020): A128—A129. http://dx.doi.org/10.1093/sleep/zsaa056.336.

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Abstract Introduction Older adolescents show heightened alertness in the evening close to the time of their Dim Light Melatonin Onset (DLMO), a time when the circadian system is most responsive to delaying light. We examined reported activities of adolescents around the time of their DLMO. Methods Forty-six adolescents (14.2-17.9 years; 24 females) who reported ≤7 h sleep on school nights and late bedtimes (school-night ≥ 23:00; non-school night ≥ midnight) slept at home on their usual school-year sleep schedule for 2 weeks. Participants reported their main activity via text message every hour

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7

Seki, Hiroyuki, Satoshi Oki, Yasunori Suda, et al. "Three-Dimensional Analysis of the First Metatarsal Bone in Minimally Invasive Distal Linear Metatarsal Osteotomy for Hallux Valgus." Foot & Ankle International 41, no. 1 (2019): 84–93. http://dx.doi.org/10.1177/1071100719875222.

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Background: Modified Bösch osteotomy (distal linear metatarsal osteotomy [DLMO]) is one of the minimally invasive correctional surgeries for hallux valgus. The 3-dimensional correctional angles and distances of the first metatarsal bone in DLMO have not been clarified. The purpose of this study was to analyze the 3-dimensional postoperative morphological changes of the first metatarsal bone in DLMO. Methods: Twenty patients (30 feet) who underwent DLMO were enrolled. Preoperative plain radiographs and computed tomography (CT) scans of the feet were examined. Postoperative radiographs and CT sc

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8

Cogswell, D., P. Bisesi, R. R. Markwald, et al. "Identification of a Preliminary Plasma Metabolome-based Biomarker for Circadian Phase in Humans." Journal of Biological Rhythms 36, no. 4 (2021): 369–83. http://dx.doi.org/10.1177/07487304211025402.

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Measuring individual circadian phase is important to diagnose and treat circadian rhythm sleep-wake disorders and circadian misalignment, inform chronotherapy, and advance circadian science. Initial findings using blood transcriptomics to predict the circadian phase marker dim-light melatonin onset (DLMO) show promise. Alternatively, there are limited attempts using metabolomics to predict DLMO and no known omics-based biomarkers predict dim-light melatonin offset (DLMOff). We analyzed the human plasma metabolome during adequate and insufficient sleep to predict DLMO and DLMOff using one blood

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9

Reiter, Andrew M., Charli Sargent, and Gregory D. Roach. "No Effect of Chronotype on Sleepiness, Alertness, and Sustained Attention during a Single Night Shift." Clocks & Sleep 3, no. 3 (2021): 377–86. http://dx.doi.org/10.3390/clockssleep3030024.

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The study’s aim was to examine the effect of chronotype on cognitive performance during a single night shift. Data were collected from 72 (36f) young, healthy adults in a laboratory study. Participants had a 9 h sleep period (03:00–12:00) followed by an 8 h night shift (23:00–07:00). During the night shift, participants completed five test sessions, which included measures of subjective sleepiness, subjective alertness, and sustained attention (i.e., psychomotor vigilance task; PVT). Dim light melatonin onset (DLMO) was derived from saliva samples taken during the evening preceding the night s

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10

Wan, Cheng, Andrew W. Mchill, Elizabeth B. Klerman, and Akane Sano. "Sensor-Based Estimation of Dim Light Melatonin Onset Using Features of Two Time Scales." ACM Transactions on Computing for Healthcare 2, no. 3 (2021): 1–15. http://dx.doi.org/10.1145/3447516.

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Circadian rhythms influence multiple essential biological activities, including sleep, performance, and mood. The dim light melatonin onset (DLMO) is the gold standard for measuring human circadian phase (i.e., timing). The collection of DLMO is expensive and time consuming since multiple saliva or blood samples are required overnight in special conditions, and the samples must then be assayed for melatonin. Recently, several computational approaches have been designed for estimating DLMO. These methods collect daily sampled data (e.g., sleep onset/offset times) or frequently sampled data (e.g

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11

Lee, J., S. Kim, S. Lee, I. Suh, J. Jang, and J. Jhoo. "0047 The Change in Melatonin Rhythm Depending on Dementia Severity in Alzheimer’s Disease (AD) Patients." Sleep 43, Supplement_1 (2020): A19. http://dx.doi.org/10.1093/sleep/zsaa056.046.

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Abstract Introduction In Alzheimer’s disease (AD), both sleep and circadian dysfunctions are commonly reported and these are associated with neurodegenerative change. Actually, it has been reported that changes in circadian rhythms in AD were apparently discrete from those seen in normal aging. Previous studies reported the delayed phase in the activity or core body temperature rhythms in severe AD patients compared to normal controls. However, it is unknown whether similar changes in melatonin rhythms occur in AD patients who were not severely demented. We aimed to compare melatonin rhythms d

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12

Stockdale, John J. "A Test of DLOM Computational Models." Business Valuation Review 27, no. 3 (2008): 131–37. http://dx.doi.org/10.5791/0882-2875-27.3.131.

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13

Cogswell, D. T., P. J. Bisesi, R. R. Markwald, et al. "0050 Identification of a Plasma Metabolome-Based Biomarker for Dim-Light Melatonin Offset and Onset in Humans." Sleep 43, Supplement_1 (2020): A20—A21. http://dx.doi.org/10.1093/sleep/zsaa056.049.

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Abstract Introduction Easily measuring individual circadian timing is increasingly important to inform personalized chronotherapy, screen for circadian disorders and circadian misalignment, and advance circadian research. Findings from multiple studies show that transcriptomics is a viable method to estimate dim-light melatonin onset (DLMO), but no published omics-based findings have predicted dim-light melatonin offset (DLMOff), and only one known study has used metabolomics to predict DLMO. Here, we developed and tested a plasma metabolomics-based biomarker of circadian phase using DLMO and

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14

Rea, Mark S., Mariana G. Figueiro, Katherine M. Sharkey, and Mary A. Carskadon. "Relationship of Morning Cortisol to Circadian Phase and Rising Time in Young Adults with Delayed Sleep Times." International Journal of Endocrinology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/749460.

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The present study was aimed at further elucidating the relationship between circadian phase, rising time, and the morning cortisol awakening response (CAR). The results presented here are a secondary analysis of experimental data obtained from a study of advanced sleep-wake schedules and light exposures on circadian phase advances measured by dim-light melatonin onset (DLMO). The present results demonstrate that morning CAR is strongly related to rising time and more weakly related to DLMO phase.

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15

Comment, Robert. "Business Valuation, DLOM, andDaubert:The Issue of Redundancy." Business Valuation Review 29, no. 3 (2010): 83–96. http://dx.doi.org/10.5791/0897-1781-29.3.83.

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16

Weihe, Ulrich, Marco Milán, and Stephen M. Cohen. "Regulation of Apterous activity inDrosophilawing development." Development 128, no. 22 (2001): 4615–22. http://dx.doi.org/10.1242/dev.128.22.4615.

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Apterous is a LIM-homeodomain protein that confers dorsal compartment identity in Drosophila wing development. Apterous activity requires formation of a complex with a co-factor, Chip/dLDB. Apterous activity is regulated during wing development by dLMO, which competes with Apterous for complex formation. Here, we present evidence that complex formation between Apterous, Chip and DNA stabilizes Apterous protein in vivo. We also report that a difference in the ability of Chip to bind the LIM domains of Apterous and dLMO contributes to regulation of activity levels in vivo.

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17

Stone, Julia E., Elise M. McGlashan, Nina Quin, et al. "The Role of Light Sensitivity and Intrinsic Circadian Period in Predicting Individual Circadian Timing." Journal of Biological Rhythms 35, no. 6 (2020): 628–40. http://dx.doi.org/10.1177/0748730420962598.

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There is large interindividual variability in circadian timing, which is underestimated by mathematical models of the circadian clock. Interindividual differences in timing have traditionally been modeled by changing the intrinsic circadian period, but recent findings reveal an additional potential source of variability: large interindividual differences in light sensitivity. Using an established model of the human circadian clock with real-world light recordings, we investigated whether changes in light sensitivity parameters or intrinsic circadian period could capture variability in circadia

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18

Milan, M., and S. M. Cohen. "Temporal regulation of apterous activity during development of the Drosophila wing." Development 127, no. 14 (2000): 3069–78. http://dx.doi.org/10.1242/dev.127.14.3069.

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Dorsoventral axis formation in the Drosophila wing depends on the activity of the selector gene apterous. Although selector genes are usually thought of as binary developmental switches, we find that Apterous activity is negatively regulated during wing development by its target gene dLMO. Apterous-dependent expression of Serrate and fringe in dorsal cells leads to the restricted activation of Notch along the dorsoventral compartment boundary. We present evidence that the ability of cells to participate in this Apterous-dependent cell-interaction is under spatial and temporal control. Apterous

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Stone, J. E., E. M. McGlashan, S. W. Cain, and A. J. Phillips. "0433 Targeting Light Sensitivity Parameters to Optimize Circadian Phase Predictions." Sleep 43, Supplement_1 (2020): A166. http://dx.doi.org/10.1093/sleep/zsaa056.430.

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Abstract Introduction Existing models of the human circadian clock accurately predict phase at group-level but not at individual-level. Interindividual variability in light sensitivity is not currently accounted for in these models and may be a practical approach to improving individual-level predictions. Using the gold-standard predictive model, we (i) identified whether varying light sensitivity parameters produces meaningful changes in predicted phase in field conditions; and (ii) tested whether optimizing parameters can significantly improve accuracy of circadian phase prediction. Methods

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20

Silva, Ana, Diego Simón, Bruno Pannunzio, Cecilia Casaravilla, Álvaro Díaz, and Bettina Tassino. "Chronotype-Dependent Changes in Sleep Habits Associated with Dim Light Melatonin Onset in the Antarctic Summer." Clocks & Sleep 1, no. 3 (2019): 352–66. http://dx.doi.org/10.3390/clockssleep1030029.

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Dim light melatonin onset (DLMO) is the most reliable measure of human central circadian timing. Its modulation by light exposure and chronotype has been scarcely approached. We evaluated the impact of light changes on the interaction between melatonin, sleep, and chronotype in university students (n = 12) between the Antarctic summer (10 days) and the autumn equinox in Montevideo, Uruguay (10 days). Circadian preferences were tested by validated questionnaires. A Morningness–Eveningness Questionnaire average value (47 ± 8.01) was used to separate late and early participants. Daylight exposure

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21

Hasler, B. P., A. M. Soehner, W. Ngari, and D. B. Clark. "0068 Circadian Alignment Predicts Neural Response to Monetary Reward in Late Adolescent Drinkers." Sleep 43, Supplement_1 (2020): A27—A28. http://dx.doi.org/10.1093/sleep/zsaa056.066.

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Abstract Introduction Abundant evidence from animal models implicates the circadian system in modulating the brain’s reward circuitry, but evidence in humans has been more limited. In particular, published evidence has relied on self-report and/or behavioral proxies of circadian misalignment and cross-sectional designs. Here, we employed objective measures and a prospective design to assess whether circadian alignment predicts the neural response to reward in a sample of late adolescent drinkers. Methods Participants included 23 late adolescents (18–22 y/o; 14 females) reporting weekly alcohol

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22

Hisler, Garrett, David Dickinson, and Brant Hasler. "084 Does Alignment between the Timing of Sleep and Circadian Rhythm Predict Behavioral Decision Making?" Sleep 44, Supplement_2 (2021): A35—A36. http://dx.doi.org/10.1093/sleep/zsab072.083.

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Abstract Introduction Cognitive performance and decision making have been shown to suffer under conditions of misalignment between circadian preference and time-of-assessment; however, little is known about how misalignment between the timing of sleep and circadian rhythm impacts decision making. To this end, this study captured naturally occurring degrees of alignment between the timing of sleep and the circadian rhythm (i.e., alignment of sleep-wake timing with circadian phase) to examine if greater misalignment predicts worse behavioral decision making. Methods Over the course of two weeks,

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Hartstein, Lauren, Lameese Akacem, Cecilia Diniz Behn, Shelby Stowe, Kenneth Wright, and Monique LeBourgeois. "156 Evening Light-Induced Circadian Phase Shift in Preschool-Aged Children." Sleep 44, Supplement_2 (2021): A63—A64. http://dx.doi.org/10.1093/sleep/zsab072.155.

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Abstract Introduction In adults, exposure to light at night delays the timing of the circadian clock in a dose-dependent manner with intensity. Although children’s melatonin levels are highly suppressed by evening bright light, the sensitivity of young children’s circadian timing to evening light is unknown. This research aimed to establish an illuminance response curve for phase delay in preschool children as a result of exposure to varying light intensities in the hour before bedtime. Methods Healthy children (n=36, 3.0 – 4.9 years, 39% males), participated in a 10-day protocol. For 7 days,

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Katsanis, Marc Steven. "Stand Up and Shout—It Is Another DLOM Put Model!" Business Valuation Review 31, no. 1 (2012): 48–52. http://dx.doi.org/10.5791/bvr-d-12-00003.1.

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McHill, Andrew, Charles Czeisler, Andrew Phillips, et al. "Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults." Nutrients 11, no. 3 (2019): 587. http://dx.doi.org/10.3390/nu11030587.

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The timing of caloric intake is a risk factor for excess weight and disease. Growing evidence suggests, however, that the impact of caloric consumption on metabolic health depends on its circadian phase, not clock hour. The objective of the current study was to identify how individuals consume calories and macronutrients relative to circadian phase in real-world settings. Young adults (n = 106; aged 19 ± 1 years; 45 females) photographically recorded the timing and content of all calories for seven consecutive days using a smartphone application during a 30-day study. Circadian phase was deter

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Larcher, Sandra, Anne-Sophie Gauchez, Sandrine Lablanche, Jean-Louis Pépin, Pierre-Yves Benhamou, and Anne-Laure Borel. "Impact of sleep behavior on glycemic control in type 1 diabetes: the role of social jetlag." European Journal of Endocrinology 175, no. 5 (2016): 411–19. http://dx.doi.org/10.1530/eje-16-0188.

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BackgroundSleep behavior is changing toward shorter sleep duration and a later chronotype. It results in a sleep debt that is acquitted on work-free days, inducing a small but recurrent sleep misalignment each week, referred to as “social jetlag”. These sleep habits could affect health through misalignment with circadian rhythms.ObjectivesThe primary objective is to address the impact of sleep behavior on glycemic control, assessed by HbA1c, in patients with type 1 diabetes, independently of other lifestyle or sleep-related factors. The secondary objective is to address whether circadian phase

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27

Baehr, Erin K., Charmane I. Eastman, William Revelle, Susan H. Losee Olson, Lisa F. Wolfe, and Phyllis C. Zee. "Circadian phase-shifting effects of nocturnal exercise in older compared with young adults." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284, no. 6 (2003): R1542—R1550. http://dx.doi.org/10.1152/ajpregu.00761.2002.

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Exercise can phase shift the circadian rhythms of young adults if performed at the right time of day. Similar research has not been done in older adults. This study examined the circadian phase-delaying effects of a single 3-h bout of low-intensity nocturnal exercise in older ( n = 8; 55–73 yr old) vs. young ( n = 8; 20–32 yr old) adults. The exercise occurred at the beginning of each subject's habitual sleep time, and subjects sat in a chair in dim light during the corresponding time in the control condition. The dim-light melatonin onset (DLMO) was used as the circadian phase marker. The DLM

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Horowitz, Todd S., Brian E. Cade, Jeremy M. Wolfe, and Charles A. Czeisler. "Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work." American Journal of Physiology-Endocrinology and Metabolism 281, no. 2 (2001): E384—E391. http://dx.doi.org/10.1152/ajpendo.2001.281.2.e384.

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We tested the hypothesis that circadian adaptation to night work is best achieved by combining bright light during the night shift and scheduled sleep in darkness. Fifty-four subjects participated in a shift work simulation of 4 day and 3 night shifts followed by a 38-h constant routine (CR). Subjects received 2,500 lux ( Bright Light) or 150 lux ( Room Light) during night shifts and were scheduled to sleep (at home in darkened bedrooms) from 0800 to 1600 ( Fixed Sleep) or ad libitum ( Free Sleep). Dim light melatonin onset (DLMO) was measured before and after the night shifts. Both Fixed Slee

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Finnerty, John D., and Rachael W. Park. "Collars, Prepaid Forwards, and the DLOM: Volatility Is the Missing Link." Business Valuation Review 34, no. 1 (2015): 24–30. http://dx.doi.org/10.5791/0882-2875-34.1.24.

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Culnan, Elizabeth, Kathryn J. Reid, Phyllis C. Zee, Stephanie J. Crowley, and Kelly G. Baron. "Meal timing relative to DLMO: Associations with BMI and body fat." Sleep Health 7, no. 3 (2021): 339–44. http://dx.doi.org/10.1016/j.sleh.2021.01.001.

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31

Ghotbi, Neda, Luísa K. Pilz, Eva C. Winnebeck, et al. "The µMCTQ: An Ultra-Short Version of the Munich ChronoType Questionnaire." Journal of Biological Rhythms 35, no. 1 (2019): 98–110. http://dx.doi.org/10.1177/0748730419886986.

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Individuals vary in how their circadian system synchronizes with the cyclic environment (zeitgeber). Assessing these differences in “phase of entrainment”—often referred to as chronotype—is an important procedure in laboratory experiments and epidemiological studies but is also increasingly applied in circadian medicine, both in diagnosis and therapy. While biochemical measurements (e.g., dim-light melatonin onset [DLMO]) of internal time are still the gold standard, they are laborious, expensive, and mostly rely on special conditions (e.g., dim light). Chronotype estimation in the form of que

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32

Krauchi, K., C. Cajochen, D. Mori, P. Graw, and A. Wirz-Justice. "Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 4 (1997): R1178—R1188. http://dx.doi.org/10.1152/ajpregu.1997.272.4.r1178.

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The phase-shifting capacity and thermoregulatory effects of a single oral administration at 18 h of melatonin (5 mg) or S-20098, a melatonin agonist (5 or 100 mg), was investigated in eight healthy young men in a double-blind placebo crossover design. The unmasking conditions of a shortened constant-routine protocol (mini-CR) were used to collect evening phase markers of physiological parameters. In comparison to placebo, all three drug administrations induced an earlier dim-light melatonin onset (DLMO), an earlier increase in distal skin temperature, and an earlier decrease in core body tempe

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Finnerty, John D. "Using Put Option–based DLOM Models to Estimate Discounts for Lack of Marketability." Business Valuation Review 31-32, no. 4, 1-3 (2013): 165–70. http://dx.doi.org/10.5791/13-00001.1.

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Sunde, Erlend, Jelena Mrdalj, Torhild Pedersen, et al. "Role of nocturnal light intensity on adaptation to three consecutive night shifts: a counterbalanced crossover study." Occupational and Environmental Medicine 77, no. 4 (2020): 249–55. http://dx.doi.org/10.1136/oemed-2019-106049.

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ObjectivesTo investigate how a standard ceiling mounted light-emitting diode (LED)-based bright light intervention affected alertness and neurobehavioural performance during three consecutive simulated night shifts, and timing of circadian rhythm after the shifts.MethodsTwenty seven participants (20 females, 21.4±2.1 years; mean±SD) worked three consecutive night shifts (23:00–07:00) under a full-spectrum (4000 K) bright light (900 lx) and a standard light (90 lx) condition in a counterbalanced crossover design (separated by 4 weeks). Subjective alertness (Karolinska Sleepiness Scale) and neur

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Danilenko, Konstantin V., Evgeniy G. Verevkin, Viktor S. Antyufeev, Anna Wirz-Justice, and Christian Cajochen. "The hockey-stick method to estimate evening dim light melatonin onset (DLMO) in humans." Chronobiology International 31, no. 3 (2013): 349–55. http://dx.doi.org/10.3109/07420528.2013.855226.

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Asmar, Joëlle, Inna Biryukova, and Pascal Heitzler. "Drosophila dLMO-PA isoform acts as an early activator of achaete/scute proneural expression." Developmental Biology 316, no. 2 (2008): 487–97. http://dx.doi.org/10.1016/j.ydbio.2008.01.040.

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Crowley, Stephanie J., and Charmane I. Eastman. "Human Adolescent Phase Response Curves to Bright White Light." Journal of Biological Rhythms 32, no. 4 (2017): 334–44. http://dx.doi.org/10.1177/0748730417713423.

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Older adolescents are particularly vulnerable to circadian misalignment and sleep restriction, primarily due to early school start times. Light can shift the circadian system and could help attenuate circadian misalignment; however, a phase response curve (PRC) to determine the optimal time for receiving light and avoiding light is not available for adolescents. We constructed light PRCs for late pubertal to postpubertal adolescents aged 14 to 17 years. Participants completed 2 counterbalanced 5-day laboratory sessions after 8 or 9 days of scheduled sleep at home. Each session included phase a

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Eastman, CI, VA Tomaka, and SJ Crowley. "0710 REPRODUCIBILITY OF CIRCADIAN VARIABLES (MEQ, MSF, DLMO, PHASE ANGLE, AND CIRCADIAN PERIOD) OVER MONTHS." Sleep 40, suppl_1 (2017): A263. http://dx.doi.org/10.1093/sleepj/zsx050.709.

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Hisler, G., S. Pedersen, D. Clark, S. Rothenberger, and B. Hasler. "0216 Is There a Daily Rhythm in Alcohol Craving and Does It Vary by Circadian Timing?" Sleep 43, Supplement_1 (2020): A84. http://dx.doi.org/10.1093/sleep/zsaa056.214.

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Abstract Introduction People with later circadian timing tend to consume more alcohol, potentially due to altered rhythms in when and how much they crave alcohol throughout the day. However, whether circadian factors play a role in alcohol craving has received scant attention. Here, we investigated if the daily rhythm of alcohol craving varied by circadian timing in two independent studies of late adolescent and young adult drinkers. Methods In Study 1, 32 participants (18–22 years of age; 61% female; 69% White) completed momentary reports of alcohol craving five times a day for 14 days. Parti

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Biryukova, Inna, Joëlle Asmar, Houari Abdesselem, and Pascal Heitzler. "Drosophila mir-9a regulates wing development via fine-tuning expression of the LIM only factor, dLMO." Developmental Biology 327, no. 2 (2009): 487–96. http://dx.doi.org/10.1016/j.ydbio.2008.12.036.

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Reiter, Andrew M., Charli Sargent, and Gregory D. Roach. "Finding DLMO: estimating dim light melatonin onset from sleep markers derived from questionnaires, diaries and actigraphy." Chronobiology International 37, no. 9-10 (2020): 1412–24. http://dx.doi.org/10.1080/07420528.2020.1809443.

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Pullman, Rebecca E., Stephanie E. Roepke, and Jeanne F. Duffy. "Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO)." Sleep Medicine 13, no. 6 (2012): 703–6. http://dx.doi.org/10.1016/j.sleep.2011.11.008.

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Crowley, Stephanie J., Christine Acebo, Gahan Fallone, and Mary A. Carskadon. "Estimating Dim Light Melatonin Onset (DLMO) Phase in Adolescents Using Summer or School-Year Sleep/Wake Schedules." Sleep 29, no. 12 (2006): 1632–41. http://dx.doi.org/10.1093/sleep/29.12.1632.

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Leibenluft, Ellen, Susana Feldman-Naim, Erick H. Turner, Paul J. Schwartz, and Thomas A. Wehr. "Salivary and plasma measures of dim light melatonin onset (DLMO) in patients with rapid cycling bipolar disorder." Biological Psychiatry 40, no. 8 (1996): 731–35. http://dx.doi.org/10.1016/0006-3223(95)00488-2.

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Schaap, E., C. Sagong, A. S. Cuamatzi Castelan, et al. "0006 The Role of Stress in Sleep in Night Shift Workers: Going Beyond Circadian Misalignment." Sleep 43, Supplement_1 (2020): A2—A3. http://dx.doi.org/10.1093/sleep/zsaa056.005.

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Abstract Introduction Despite a growing need for nighttime work, few studies have characterized the causes of sleep disturbance in night shift workers beyond circadian misalignment. Recent research suggest that high sleep reactivity to stress (a predisposition for sleep disturbance due to stress) may also lead to sleep difficulties in shift workers. This study investigated if sleep reactivity is an independent predictor of daytime sleep disturbances after controlling for circadian phase. Methods Night shift workers (N= 48) completed an 8 hour polysomnography (PSG) during the daytime following

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Titone, M. K., B. McArthur, T. H. Ng, et al. "0364 Sex and Race Influence Objective and Self-Report Sleep and Circadian Measures in Emerging Adults at Risk for Bipolar Spectrum Disorder." Sleep 43, Supplement_1 (2020): A139. http://dx.doi.org/10.1093/sleep/zsaa056.361.

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Abstract Introduction There is a critical need to understand key factors that impact sleep and circadian rhythm function for emerging adults at risk for bipolar spectrum disorder (BSD). Sex and race are common demographic factors contributing to differences in health outcomes; however, the influence of these variables on sleep and circadian rhythm patterns for emerging adults at risk for BSD has not been characterized. Methods Multiple objective and self-report facets of sleep and circadian function, including dim light melatonin onset (DLMO), and measures derived from actigraphy and sleep dia

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Snitselaar, Mark A., Marcel G. Smits, Kristiaan B. van der Heijden, and Jan Spijker. "Sleep and Circadian Rhythmicity in Adult ADHD and the Effect of Stimulants." Journal of Attention Disorders 21, no. 1 (2016): 14–26. http://dx.doi.org/10.1177/1087054713479663.

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Objective: This review updates information on sleep and circadian rhythmicity in adult ADHD, especially circadian rhythmicity and the influence of stimulants. Method: Investigations into sleep, chronotype, and circadian rhythm in adult ADHD were searched in the Cochrane Library, Embase, Medline, and PsycInfo databases. Results: ADHD in adults is associated with longer objective sleep latency, irrespective of insomnia complaints. Sleep maintenance is disturbed and waking up time is delayed. Adult ADHD is associated with increased eveningness, delayed dim light melatonin onset (DLMO), and later

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Keijzer, Henry, Marcel G. Smits, Jeanne F. Duffy, and Leopold M. G. Curfs. "Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders." Sleep Medicine Reviews 18, no. 4 (2014): 333–39. http://dx.doi.org/10.1016/j.smrv.2013.12.001.

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Pandi-Perumal, Seithikurippu R., Marcel Smits, Warren Spence, et al. "Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders." Progress in Neuro-Psychopharmacology and Biological Psychiatry 31, no. 1 (2007): 1–11. http://dx.doi.org/10.1016/j.pnpbp.2006.06.020.

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Paprocka, Justyna, Marek Kijonka, Piotr Wojcieszek, Marcin Pęcka, Ewa Emich-Widera, and Maria Sokół. "Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion." International Journal of Endocrinology 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/5853167.

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The main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome (n=9) and in children with (n=80) and without (n=40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian secretion. The characteristics describing the diurnal hormone secretion such as minimum melatonin concentration, release amplitude, phase shift of melatonin release, and sleep duration as well as the dim light melatonin onset (DLMO) of melatonin secretion and theγshape parameter allow analyzing the

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