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Journal articles on the topic 'DMBA induced Carcinogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Schneider, Joanne, David Warshawsky, Kent Mitchell, et al. "Effects of DMBA Preparation on DMBA-Induced Rat Mammary Carcinogenesis." Polycyclic Aromatic Compounds 22, no. 3-4 (2002): 831–39. http://dx.doi.org/10.1080/10406630290103988.

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2

Modi, Badri G., Jason Neustadter, Elisa Binda, et al. "Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma." Science 335, no. 6064 (2012): 104–8. http://dx.doi.org/10.1126/science.1211600.

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Polyaromatic hydrocarbons (PAHs) are prevalent, potent carcinogens, and 7,12-dimethylbenz[a]anthracene (DMBA) is a model PAH widely used to study tumorigenesis. Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic cell (DC), are protected from cutaneous chemical carcinogenesis, independent of T cell immunity. Investigation of the underlying mechanism revealed that LC-deficient skin was relatively resistant to DMBA-induced DNA damage. LCs efficiently metabolized DMBA to DMBA-trans-3,4-diol, an intermediate proximal to oncogenic Hras mutation, and DMBA-treated LC-deficient skin c

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3

Anandhi Nallu, Suresh Kathiresan, Sivakumar Kathiresan, and Ilanchit chenni. "Tumour preventive potential of sclareol on 7, 12 dimethylbenz [a] anthracene (DMBA) induced hamster buccal pouch carcinogenesis." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 1182–91. http://dx.doi.org/10.26452/ijrps.v11i1.1956.

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Sclareol has demonstrated a broad variety of biological activities that belong to the antioxidant anti-inflammatory and anticancer activities that are used in traditional medicine. In the current study, we intended to explore the antitumor possible of sclareol along 7, 12-dimethylbenz (a) anthracene (DMBA) evoked golden Syrian hamster’s buccal pouch carcinogenesis. Lipid peroxidation and antioxidants were assessed by the buccal tissue, and plasma of DMBA evoked golden Syrian hamster buccal pouch carcinogenesis of observational animals. We observed 100% of tumor establishment and noted defects

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4

Rajasekaran, D., S. Manoharan, MM Prabhakar, and A. Manimaran. "Enicostemma littorale prevents tumor formation in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis." Human & Experimental Toxicology 34, no. 9 (2015): 911–21. http://dx.doi.org/10.1177/0960327114562033.

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Oral cancer is one of the most common malignancies worldwide, and India has recorded the highest annual incidence of oral cancer in comparison with other countries. Altered lipid peroxidation and antioxidant status along with defect in detoxification cascade have been implicated in the pathogenesis of several cancers including oral cancer. The aim of this study was to investigate the chemopreventive potential of ethanolic extract of Enicostemma littorale leaves (ElELet) in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumor was developed in the buccal

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5

Akrom, Akrom, Titiek Hidayati, Sagiran Sagiran та Indrayanti Indrayanti. "Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene". Indonesian Journal of Cancer Chemoprevention 10, № 3 (2019): 140. http://dx.doi.org/10.14499/indonesianjcanchemoprev10iss3pp140-148.

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Interferon-gamma (IFN-γ) is one of the central cytokines in the anti-carcinogenesis immune response. Black cumin seeds (BCS) have an active content of thymoquinone and unsaturated fatty acids with biological activity as immunomodulators. This study aimed to determine the effect of administration of BCS extract on IFN-γ secretion activity by DMBA-induced SD rat lymphocytes. In vivo experimental study on DMBA-induced SD rats, BCS extract was given with three doses for two weeks before being induced and five weeks during DMBA induction. IFN-γ levels in lymphocyte culture supernatants were determi

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6

Tsai, Ruei-Lan, Bing-Ying Ho, and Tzu-Ming Pan. "Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–8. http://dx.doi.org/10.1093/ecam/nep215.

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The prevalence of oral tumor has exponentially increased in recent years; however, the effective therapies or prevention strategies are not sufficient. Red mold rice is a traditional Chinese food, and several reports have demonstrated that red mold rice had an anti-tumor effect. However, the possible anti-tumor mechanisms of the red mold rice are unclear. In this study, we examined the anti-tumor effect of red mold rice on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced oral tumor in hamster. The ethanol extract of red mold rice (RMRE) treatment significantly decreases the levels of DMBA-in

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7

KONDO, Masanori, Kohzo TSUCHIKAWA, and Joji KATO. "Two-phase carcinogenesis on the DMBA induced carcinoma." Japanese Journal of Oral & Maxillofacial Surgery 34, no. 12 (1988): 2537–43. http://dx.doi.org/10.5794/jjoms.34.2537.

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8

Davis, Leemol, and Girija Kuttan. "Effect of Withania somnifera on DMBA induced carcinogenesis." Journal of Ethnopharmacology 75, no. 2-3 (2001): 165–68. http://dx.doi.org/10.1016/s0378-8741(00)00404-9.

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9

Hudson, Tamaro S., Bradley A. Carlson, Mark J. Hoeneroff, et al. "Selenoproteins reduce susceptibility to DMBA-induced mammary carcinogenesis." Carcinogenesis 33, no. 6 (2012): 1225–30. http://dx.doi.org/10.1093/carcin/bgs129.

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10

Anindyajati, Anindyajati, Andita Pra Darma, Ika Nurjizah, Dita Brenna Septhea, and Agung Endro Nugroho. "Ficus septica Burm. f. Leaves Ethanolic Extract Triggered Apoptosis on 7,12-Dimethylbenz[a]anthracene-Induced Rat Mammary Carcinogenesis Qualitatively." Indonesian Journal of Cancer Chemoprevention 3, no. 1 (2012): 334. http://dx.doi.org/10.14499/indonesianjcanchemoprev3iss1pp334-338.

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Ficus septica Burm. f. ethanolic extract (FEE) shows cytotoxic effects on several cancer cell lines. Our research aimed to investigate the effect of FEE on apoptosis induction and p53 expression against carcinogenesis of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced rat mammary.The research was conducted by comparing both apoptosis induction and p53 expression in DMBA-induced rats that were treated with FEE against control groups. Cells that undergo apoptosis were visualized by Double Staining method with acridine orange and ethidium bromide, while p53 expression was detected by IHC staining.

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11

Wendt, Luiz Roberto, Alessandro Bersch Osvaldt, Vivian Pierre Bersch, Rita de Cássia Schumacher, Maria Isabel Albano Edelweiss, and Luiz Rohde. "Pancreatic intraepithelial neoplasia and ductal adenocarcinoma induced by DMBA in mice: effects of alcohol and caffeine." Acta Cirurgica Brasileira 22, no. 3 (2007): 202–9. http://dx.doi.org/10.1590/s0102-86502007000300008.

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PURPOSE: To evaluate the effects of alcohol and caffeine in a pancreatic carcinogenesis mouse model induced by 7,12-dimethylbenzantracene (DMBA), according to the PanIN classification system. METHODS: 120 male, Mus musculus, CF-1 mice were divided into four groups. Animals received either water or caffeine or alcohol or alcohol + caffeine in their drinking water. In all animals, 1 mg of DMBA was implanted into the head of the pancreas. After 30 days, euthanasia was performed; excised pancreata were then fixed in formalin, stained with hematoxylin-eosin and categorized as follows: normal ducts,

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12

Naruse, Mie, Ryoichi Masui, Masako Ochiai, Yoshiaki Maru, Yoshitaka Hippo, and Toshio Imai. "An organoid-based carcinogenesis model induced by in vitro chemical treatment." Carcinogenesis 41, no. 10 (2020): 1444–53. http://dx.doi.org/10.1093/carcin/bgaa011.

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Abstract Animal carcinogenesis models induced by environmental chemicals have been widely used for basic and applied cancer research. However, establishment of in vitro or ex vivo models is essential for molecular mechanistic elucidation of early events in carcinogenesis, leading to clarification of the total mode of action. In the present study, to establish an organoid-based chemical carcinogenesis model, mouse organoids were treated in vitro with 4 genotoxic chemicals, e.g. ethyl methanesulfonate (EMS), acrylamide (AA), diethylnitrosamine (DEN) and 7,12-dimethylbenz[a]anthracene (DMBA) to e

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13

Rao, Ramesha, M. G. Das, and P. Das. "Inhibitory Action of Aminoglutethimide on DMBA-Induced Mammary Carcinogenesis." Oncology 42, no. 2 (1985): 119–21. http://dx.doi.org/10.1159/000226013.

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14

Singletary, Keith W., Minnie Q. McNary, Angela M. Odoms, Joan Nelshoppen, and Matthew A. Wallig. "Ethanol consumption and DMBA‐induced mammary carcinogenesis in rats." Nutrition and Cancer 16, no. 1 (1991): 13–23. http://dx.doi.org/10.1080/01635589109514136.

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15

Veluchamy, Vaithiyanathan, and Mirunalini Sankaran. "Impact of Whole Plant Extract of Pergularia daemia on Glycoproteins in Dimethylbenz(A)Anthracene Induced Hamster Buccal Pouch Carcinogenesis." Avicenna Journal of Medical Biochemistry 6, no. 1 (2018): 15–20. http://dx.doi.org/10.15171/ajmb.2018.04.

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Background: Oral squamous cell carcinoma is a major component of a diverse group of neoplasms often referred to as ‘head and neck cancer’. Frequent smoking and/or alcohol consumption are two major risk factors for oral cancer. Objectives: The present study was aimed to investigate the protective role of Pergularia daemia ethyl acetate and methanolic extracts (PDEAE and PDME, respectively) on glycoproteins in dimethylbenz(a) anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Materials and Methods: Male golden Syrian hamsters were used and divided into six groups. Group 2 carried 0.5

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16

Koul, Ashwani, Mohinder Pal Bansal, Aniqa Aniqa, Harsh Chaudhary, and Neha Arora Chugh. "Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice." International Journal for Vitamin and Nutrition Research 90, no. 5-6 (2020): 493–513. http://dx.doi.org/10.1024/0300-9831/a000597.

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Abstract. The present study revealed the effects of Lycopene enriched tomato extract (LycT) on chemically induced skin cancer in mice. Skin tumors were induced by topical application of 7,12-Dimethylbenz(a)anthracene (DMBA) [500 nmol/100 ul of acetone, twice a week for two weeks] and 12-O-tetradecanoyl phorbol-13-acetate (TPA) [1.7 nmol/100 ul of acetone, twice a week for eighteen weeks] and LycT (5 mg/kg b.w.) was administered orally. Male Balb/c mice were divided into four groups (n = 15 per group): control, DMBA/TPA, LycT and LycT + DMBA/TPA. The chemopreventive response of LycT to skin tum

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17

Arroyo-Acevedo, J., R. J. Chávez-Asmat, A. Anampa-Guzmán, R. Donaires, and Josέ Ráez-Gonzáles. "Protective Effect of Piper aduncum Capsule on DMBA-induced Breast Cancer in Rats." Breast Cancer: Basic and Clinical Research 9 (January 2015): BCBCR.S24420. http://dx.doi.org/10.4137/bcbcr.s24420.

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The possible protective effect of Piper aduncum capsule on DMBA (dimethylbenz[α]anthracene)-induced breast cancer in rats was assessed by monitoring the tumor and lung metastases incidence and recording hematological and biochemical parameters and frequency of micronuclei. Mammary carcinogenesis was induced in 36 female Holtzman rats by providing a single subcutaneous injection of DMBA. Oral administration of P. aduncum capsule lowered adenocarcinoma and lymph node metastases incidence. Pulmonary metastasis was significantly lowered ( P < 0.05). Hematological indicators showed that the trig

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18

Monikawati, Ameilinda, Sofa Farida, Laras Widawaty Putri, Yurista Gilang Ikhtiarsyah, and Edy Meiyanto. "Antiproliferative Activity of Ethanolic Extract of Ciplukan Herbs (Physalis angulata L.) on 7,12-Dimethylbenz[A]Nthracene-Induced Rat Mammary Carcinogenesis." Indonesian Journal of Cancer Chemoprevention 2, no. 2 (2011): 228. http://dx.doi.org/10.14499/indonesianjcanchemoprev2iss2pp228-233.

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Physalis angulata L. is an annual herb widely used as popular medicine for the treatment of cancer. Physalis angulata L. ethanolic extract (PEE) has been demonstrated to have strong cytotoxic activity against breast cancer, inhibited cancer cell’s proliferation and induced cell cycle arrest. The aim of our study is to investigate the effect of PEE as a cancer chemopreventive agent on 7,12-dimethylbenz[a]nthracene (DMBA)-induced rats mammary. The antiproliferative activity was characterized by monitoring the histopatology representation and expression of cell proliferation on DMBA-induced mamma

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19

Maeda, H., and Y. Kameyama. "Effect of excisional wounding on DMBA -induced hamster tongue carcinogenesis." Journal of Oral Pathology and Medicine 15, no. 1 (1986): 21–27. http://dx.doi.org/10.1111/j.1600-0714.1986.tb00559.x.

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20

Lin, L. M., Y. K. Chen, Y. L. Huang, R. Mostofi, and P. Toto. "Cytokeratins in hamster cheek pouch epithelium during DMBA-induced carcinogenesis." Journal of Oral Pathology and Medicine 18, no. 5 (1989): 287–90. http://dx.doi.org/10.1111/j.1600-0714.1989.tb00399.x.

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21

Li, Ning, Chi Han, and Junshi Chen. "Tea Preparations Protect Against DMBA-Induced Oral Carcinogenesis in Hamsters." Nutrition and Cancer 35, no. 1 (1999): 73–79. http://dx.doi.org/10.1207/s1532791473-79.

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22

Yang, Ya, Zeng Tong Zhou, and Jian Ping Ge. "Effect of genistein on DMBA-induced oral carcinogenesis in hamster." Carcinogenesis 27, no. 3 (2005): 578–83. http://dx.doi.org/10.1093/carcin/bgi234.

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23

Russo, IH, M. Koszalka, PA Gimotty, and J. Russo. "Protective effect of chorionic gonadotropin on DMBA-induced mammary carcinogenesis." British Journal of Cancer 62, no. 2 (1990): 243–47. http://dx.doi.org/10.1038/bjc.1990.268.

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24

Yamamoto, Hiroyuki, Joohyun Ryu, Eli Min, et al. "TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis." Journal of Investigative Dermatology 137, no. 6 (2017): 1322–32. http://dx.doi.org/10.1016/j.jid.2016.12.026.

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25

Sulfianti, Asri, Nur Hasanah, Agung Eru Wibowo, Kurnia Agustini, and I. Made Artika. "Potency of Curcuma aeruginosa as A Chemopreventive Candidate Agent on 7,12-Dimethylbenz[a]anthracene (DMBA)-Induced Rat Spleen." ANNALES BOGORIENSES 23, no. 2 (2020): 58. http://dx.doi.org/10.14203/ann.bogor.2019.v23.n2.58-65.

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Present investigation shows that the extract of C. aeruginosa attenuates DMBA-induced spleen carcinogenesis in Wistar rats. Three-week female Wistar rats were treated with three different C. aeruginosa extract doses (CA1: 40 mg/200 g body weight, BW; CA2: 80 mg/200 g BW; CA3: 160 mg/200 g BW) and were induced with DMBA after one-week administration of these doses. A commercial immunostimulant, and DMBA only were also given to each group as positive and negative control, respectively. The development of tumors was evaluated by investigating the incidence of tumor and tumor multiplicity during t

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26

Yusuf, Nabiha, Tahseen H. Nasti, Sreelatha Meleth, and Craig A. Elmets. "Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis." Molecular Carcinogenesis 48, no. 8 (2009): 713–23. http://dx.doi.org/10.1002/mc.20517.

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27

Barros, Alfredo Carlos S. D., Elisa Naomi K. Muranaka, Lincon Jo Mori, et al. "Induction of experimental mammary carcinogenesis in rats with 7,12-dimethylbenz(a)anthracene." Revista do Hospital das Clínicas 59, no. 5 (2004): 257–61. http://dx.doi.org/10.1590/s0041-87812004000500006.

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PURPOSE: To test an experimental model of chemical mammary carcinogenesis induction in rats. METHODS: Twenty young virgin Sprague-Dawley female rats, aged 47 days, received 20 mg of 7,12-dimethylbenz(a)anthracene (DMBA) intragastrically by gavage. Afterwards, at 8 and 13 weeks, their mammary glands were examined. At the end of the experiment, the animals were sacrificed, and the mammary tumors were measured and weighed. Tumor fragments were analyzed using light microscopy. RESULTS: Eight weeks after DMBA injection, 16 rats presented at least 1 breast tumor (80%). After 13 weeks, all of them (1

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28

Yee Chan, Ho, and Lai K. Leung. "A potential protective mechanism of soya isoflavones against 7,12-dimethylbenz[a]anthracene tumour initiation." British Journal of Nutrition 90, no. 2 (2003): 457–65. http://dx.doi.org/10.1079/bjn2003913.

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Epidemiological studies indicate that Asian women have a lower breast cancer incidence compared with their counterparts in the West, and the difference has been related to soya consumption. Animal studies have suggested that soya may prevent dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis in the breast. In the present study a cell culture model was developed to address the effect of soya isoflavones on the DMBA-induced DNA damage. DMBA is metabolized into a DNA-attacking moiety by two phase I cytochrome P450 (CYP) enzymes CYP1A1 and CYP1B1. DNA mutation caused by this genotoxic agent i

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29

Martínez B., Diana A., Paola Andrea Barato Gómez, Carlos Arturo Iregui Castro, and Jaiver E. Rosas Pérez. "DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition." BioMed Research International 2020 (February 14, 2020): 1–8. http://dx.doi.org/10.1155/2020/1470868.

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Objectives. To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters’ right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 4) were painted with mineral oil only. Two animals were sacrificed every three weeks to obtain histological samples and to evaluate pathological abnormalities. After 12 wee

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30

Rezazadeh, H., A. R. Nayebi, and M. Athar. "Role of iron–dextran on 7,12-dimethylbenz(a) anthracene-initiated and croton oil-promoted cutaneous tumorigenesis in normal and pregnant mice." Human & Experimental Toxicology 20, no. 9 (2001): 471–76. http://dx.doi.org/10.1191/096032701682693044.

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Skin chemical carcinogenesis has been divided into the process of initiation, promotion and progression. Earlier, we showed the role of iron overload in the promotion stage of skin carcinogenesis. In this communication, we report that iron overload does not augment croton oil-mediated tumor promotion in 7,12-dimethylbenz(a)anthracene (DMBA)-initiated pregnant mice skin tumorigenesis. Virgin female Swiss mice were given 1 mg iron/mouse/day parenterally for 2 weeks to induce iron overload. After the last injection, a group of mice was left with male mice for 10 days. These animals showed an incr

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Wang, Mian-Ying, Lin Peng, Gary Anderson, and Diane Nowicki. "Breast cancer prevention with Morinda citrifolia (noni) at the initiation stage." Functional Foods in Health and Disease 3, no. 6 (2013): 203. http://dx.doi.org/10.31989/ffhd.v3i6.53.

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Background: It has been reported that noni has multiple health benefits for over 2000 years. In this study, the cancer preventive effects of Tahitian noni® juice (TNJ) at the initiation stage on DMBA-induced mammary tumorigenesis in female SD rats was investigated.Objective: We took advantage of the DMBA-induced mammary carcinogenic model to study the preventive effects of TNJ at the initiation stage of mammary carcinogenesis in female SD rats by using clinical observation, pathological examination, and 32P-postlabeling assay.Methods: One hundred and sixty female SD rats were divided into eigh

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Barroso, Poliana Ribeiro, Flaviana Dornela Verli, Ricardo Lopes Rocha, Nadia Lages Lima, Bethania Alves de Avelar, and Gustavo Eustaquio Brito Alvim de Melo. "Effect of crude latex from Euphorbia tirucalli on DMBA-induced carcinogenesis." Journal of Histology and Histopathology 4, no. 1 (2017): 3. http://dx.doi.org/10.7243/2055-091x-4-3.

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33

Nicol, C. J. "PPAR influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis." Carcinogenesis 25, no. 9 (2004): 1747–55. http://dx.doi.org/10.1093/carcin/bgh160.

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34

Hayashi, K., Y. Momoi, N. Tanuma, et al. "Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA." Oncogene 34, no. 35 (2014): 4647–55. http://dx.doi.org/10.1038/onc.2014.398.

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35

Masubuchi, Y., S. Fujita, and T. Suzuki. "A possible mechanism for Sudan III-induced prevention of DMBA carcinogenesis." Mutation Research/Environmental Mutagenesis and Related Subjects 182, no. 6 (1987): 365–66. http://dx.doi.org/10.1016/0165-1161(87)90099-9.

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36

Kiss, Alexi, Aaron Koppel, Emily Murphy та ін. "Cell Type-Specific p38δ Targeting Reveals a Context-, Stage-, and Sex-Dependent Regulation of Skin Carcinogenesis". International Journal of Molecular Sciences 20, № 7 (2019): 1532. http://dx.doi.org/10.3390/ijms20071532.

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Activation and/or upregulated expression of p38δ are demonstrated in human skin malignancies including cutaneous squamous cell carcinoma, suggesting a role for p38δ in skin carcinogenesis. We previously reported that mice with germline deletion of the p38δ gene are significantly protected from chemical skin carcinogenesis. Here, we investigated the effects of cell-selective targeted ablation of p38δ in keratinocytes and in immune (myeloid) cells on skin tumor development in a two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) chemical mouse skin carcinog

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Buddhan R, Manoharan S, and Muralinaidu R. "Myrtenal averts apoptotic evasion of cancer cells in 7,12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 2838–47. http://dx.doi.org/10.26452/ijrps.v11i3.2359.

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Apoptotic avoidance is one of the foremost characteristic features of tumour cells. Apoptotic induction in cancer cells could thus help to identify new anticancer agents from the natural products. The present study has taken an effort to investigate the apoptotic efficacy of myrtenal, a monoterpene, in 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinoma in male golden Syrian hamsters. The present study used the potent carcinogen, 7,12- dimethylbenz(a)anthracene, to develop oral tumours in the buccal pouches of the golden Syrian hamsters. Topical application of the above said carcinoge

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Ojeswi, BK, M. Khoobchandani, DK Hazra, and MM Srivastava. "Protective effect of Thuja occidentalis against DMBA-induced breast cancer with reference to oxidative stress." Human & Experimental Toxicology 29, no. 5 (2010): 369–75. http://dx.doi.org/10.1177/0960327110364150.

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In vivo experiment has been conducted to observe the preventive role of Thuja occidentalis Linn (leaves) against 7, 12 dimethylbenz(a)anthracene (DMBA)-induced mammary cancer. Ethyl acetate (EtOAc) and methanolic (MeOH) extracts in two doses (5 and 10 mg/kg body weight) of the plant were tested for DMBA-induced Indian Cancer Research Centre (ICRC) mice mammary carcinoma in terms of tumor weight, volume, life span, histological variation and oxidative stress against the reference drug doxorubicin using standard animal protocol. EtOAc extract (10 mg/kg body weight) of the plant exhibits reductio

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Vijayalakshmi, Sankaran, Arokia Vijaya Anand Mariadoss, Vinayagam Ramachandran, et al. "Polydatin Encapsulated Poly [Lactic-co-glycolic acid] Nanoformulation Counteract the 7,12-Dimethylbenz[a] Anthracene Mediated Experimental Carcinogenesis through the Inhibition of Cell Proliferation." Antioxidants 8, no. 9 (2019): 375. http://dx.doi.org/10.3390/antiox8090375.

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In the present study, the authors have attempted to fabricate Polydatin encapsulated Poly [lactic-co-glycolic acid] (POL-PLGA-NPs) to counteract 7,12-dimethyl benzyl anthracene (DMBA) promoted buccal pouch carcinogenesis in experimental animals. The bio-formulated POL-PLGA-NPs were characterized by dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD) pattern analysis, and transmission electron microscope (TEM). In addition, the nano-chemopreventive potential of POL-PLGA-NPs was assessed by scrutinizing the neoplastic incidence and analy

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de Souza, Fernanda Lopes, Mariana Oliveira, Marianne Brochado Nunes, et al. "Sunitinib Improves Some Clinical Aspects and Reverts DMBA-Induced Hyperplasic Lesions in Hamster Buccal Pouch." ISRN Otolaryngology 2014 (February 13, 2014): 1–7. http://dx.doi.org/10.1155/2014/859621.

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Oral squamous cell carcinoma (OSCC) is a public health problem. The hamster buccal pouch model is ideal for analyzing the development of OSCC. This research analysed the effects of sunitinib (tyrosine kinase inhibitor) in precancerous lesions induced by 7,12-dimethylbenz(a)anthracene (DMBA) in this model. Thirty-four male hamsters, divided into six groups: control—C n=7, acetone—A n=12, carbamide peroxide—CP n=5, acetone and CP—A+CP n=8, 1% DMBA in acetone and CP—DA+CP n=6, and 1% DMBA in acetone and CP and 4-week treatment with sunitinib—DA+CP+S n=7. The aspects evaluated were anatomopatholog

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Chang, Soo, Chen, and Shyur. "Essential Oil of Mentha aquatica var. Kenting Water Mint Suppresses Two-Stage Skin Carcinogenesis Accelerated by BRAF Inhibitor Vemurafenib." Molecules 24, no. 12 (2019): 2344. http://dx.doi.org/10.3390/molecules24122344.

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The v-raf murine sarcoma viral homolog B1 (BRAF) inhibitor drug vemurafenib (PLX4032) is used to treat melanoma; however, epidemiological evidence reveals that it could cause cutaneous keratoacanthomas and squamous cell carcinoma in cancer patients with the most prevalent HRASQ61L mutation. In a two-stage skin carcinogenesis mouse model, the skin papillomas induced by 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) (DT) resemble the lesions in BRAF inhibitor-treated patients. In this study, we investigated the bioactivity of Mentha aquatica var. Kenting Water M

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Ebenezar, Jeyasingh, Prakasa Rao Aruna, and Singaravelu Ganesan. "Native fluorescence spectroscopic characterization of DMBA induced carcinogenesis in mice skin for the early detection of tissue transformation." Analyst 140, no. 12 (2015): 4170–81. http://dx.doi.org/10.1039/c4an00650j.

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The objective of the study is to characterize the endogenous porphyrin fluorescence in a dimethylbenz(a)anthracene (DMBA) induced mouse skin tumor model using native fluorescence emission and excitation spectroscopy.

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L'Abbé, Mary R., Peter W. F. Fischer, Keith D. Trick, and Eduardo R. Chavez. "Prospective study on selenium and antioxidant status during dmba-induced mammary carcinogenesis." Nutrition Research 10, no. 12 (1990): 1431–39. http://dx.doi.org/10.1016/s0271-5317(05)80135-6.

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Kaufmann, Yihong, Paul Spring, and V. Suzanne Klimberg. "Oral glutamine prevents DMBA-induced mammary carcinogenesis via upregulation of glutathione production." Nutrition 24, no. 5 (2008): 462–69. http://dx.doi.org/10.1016/j.nut.2008.01.003.

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Chang, Jia‐Ming, Wu‐Chaw Chen, Dajis Hong, and Jen‐Kun Lin. "The inhibition of DMBA‐induced carcinogenesis by neoxanthin in hamster buccal pouch." Nutrition and Cancer 24, no. 3 (1995): 325–33. http://dx.doi.org/10.1080/01635589509514421.

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Karthikeyan, K., P. Ravichandran, and S. Govindasamy. "Chemopreventive effect of Ocimum sanctum on DMBA-induced hamster buccal pouch carcinogenesis." Oral Oncology 35, no. 1 (1999): 112–19. http://dx.doi.org/10.1016/s1368-8375(98)00035-9.

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Lin, Ming-Hsun, Su-Ching Hsieh, Shuan Yow Li, et al. "Sequential cytogenetic alterations in hamster oral keratinocytes during DMBA-induced oral carcinogenesis." European Journal of Cancer Part B: Oral Oncology 30, no. 4 (1994): 252–64. http://dx.doi.org/10.1016/0964-1955(94)90007-8.

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Goodwin, W. Jarrard, Gerard D. Bordash, Jun Wu Xue, Frans Huijing, and Norman Altman. "Selenium Inhibition of Chemical Carcinogenesis in the Upper Aerodigestive Tract of Hamsters." Otolaryngology–Head and Neck Surgery 93, no. 3 (1985): 373–79. http://dx.doi.org/10.1177/019459988509300316.

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Evidence suggests that ingestion of selenium compounds may inhibit carcinogenesis. We studied this in hamsters in which squamous cell carcinoma of the tongue was induced with 0.5% dimethylbenzanthracene (DMBA). Forty-five hamsters, divided into three groups of 15 each, were fed a low-selenium diet and the left lateral border of the tongue was painted with DMBA three times a week. Control animals were given deionized water, while water for animals in groups 1 and 2 contained 3 and 6 ppm selenium, respectively. All sufficiently long-lived animals developed leukoplakia of the tongue and floor of

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Ali, Huma, and Savita Dixit. "Extraction Optimization ofTinospora cordifoliaand Assessment of the Anticancer Activity of Its Alkaloid Palmatine." Scientific World Journal 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/376216.

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Objective. To optimize the conditions for the extraction of alkaloid palmatine fromTinospora cordifoliaby using response surface methodology (RSM) and study its anticancerous property against 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice.Methods. The effect of three independent variables, namely, extraction temperature, time, and cycles was investigated by using central composite design. A single topical application of DMBA (100 μg/100 μL of acetone), followed 2 weeks later by repeated application of croton oil (1% in acetone three times a week) for 16

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Chan, Ho Yee, Huan Wang, and Lai K. Leung. "The red clover (Trifolium pratense) isoflavone biochanin A modulates the biotransformation pathways of 7, 12-dimethylbenz[a]anthracene." British Journal of Nutrition 90, no. 1 (2003): 87–92. http://dx.doi.org/10.1079/bjn2003868.

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Several flavonoids have shown their anti-carcinogenic effects in various models. The soyabean isoflavone genistein was demonstrated earlier in our laboratory to be an effective inhibitor of dimethylbenz[a]anthracene (DMBA)-induced DNA damage in MCF-7 cells by curbing cytochrome P450 (CYP) 1 enzymes. The red clover (Trifolium pratense) isoflavone biochanin A is a methylated derivative of genistein, and its anti-mutagenic effect in bacterial cells has been shown previously. Because of its protection against chemical carcinogenesis in an animal model, biochanin A was selected for testing in our e

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