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1

Rathore, Bhumika, Anitha R. Sagarkar, and Pushpanjali Krishnappa. "Comparative performance assessment of composite indicators for DMFT, DMFS, FS-T and T-Health indices among a 35-44 year old urban population: A cross-sectional study." Journal of Global Oral Health 2 (September 25, 2019): 9–15. http://dx.doi.org/10.25259/jgoh_11_2018.

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Introduction: Several limitations of decayed, missing, and filled teeth (DMFT) (DMF surfaces [DMFS]) have been addressed with the introduction of new composite indicators such as filled and sound teeth (FS-T) and T-health. These indices not only reflect the determinants of oral health but also reveal the utilization of health services and help in planning health programs. Objectives: The objectives of this study were to assess the dentition status and extract DMFT, DMFS, FS-T, and T-health scores and to determine which of the four would represent the dentition status of a population. Basic Research Design: A cross-sectional study was planned to collect data through probability proportionate sampling. Participants: Two hundred and forty-one individuals aged between 35–44 years old residing in Bangalore city. Sociodemographic data were collected and oral examination of subjects was done to obtain the scores for DMFT, DMFS, FS-T, and T-health indices. Data obtained were analyzed using the SPSS version 19. Results: DMFS index showed maximum variance of 8.5% followed by T-health index which was 7.7%. FS-T showed the variance of 7.2%. Among the individual components, missing teeth component and sound functional teeth showed the maximum variance of 7.6% and 7.1%, respectively. Conclusion: DMFS as an indicator of dentition status is more sensitive than the other three compared indices in identifying sociodemographic factors, utilization of health services by a population, and perceptions about oral health as determinants of oral health.
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Marks, R. G., R. D'Agostino, J. E. Moorhead, A. J. Conti, and L. Cancro. "A Fluoride Dose-response Evaluation in an Anticaries Clinical Trial." Journal of Dental Research 71, no. 6 (June 1992): 1286–91. http://dx.doi.org/10.1177/00220345920710060401.

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This study evaluated the dose-response relationship between four increasing levels of fluoride from 1000 to 2500 ppm F as sodium monofluorophosphate (MFP) and three-year dental caries increments, as measured by DMFS, DMFT, and DFS-A on 4424 schoolchildren. The results indicated consistent linear decreases in all three dental indices as the dose level increased to 2500 ppm F MFP, with slopes (average reductions) of 0.32 in DMFS for an increase of 1000 ppm F, 0.13 in DMFT, and 0.17 in DFS-A when all children were evaluated, p < 0.03 for each index. For children 11 years and older at baseline, the slopes quadrupled, p < 0.01 for each index. Age and baseline DMFS were shown to be the most important covariates to control for in the statistical models. No differences in adverse reactions, or other safety problems, were observed at the different dose levels.
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Ivanisevic, Zrinka, Marko Matijevic, Zvonimir Uzarevic, Djordje Petrovic, Davor Jurlina, and Vjekoslav Jerolimov. "Prevalence of dental caries among children of SOS children's village in Croatia." Vojnosanitetski pregled 76, no. 2 (2019): 123–28. http://dx.doi.org/10.2298/vsp170117061i.

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Background/Aim. Oral health is an integral part of general health and an important factor in the overall quality of life. The purpose of this study was to investigate the prevalence of dental caries among the children from the SOS Children?s Village in Croatia. Methods. The dental examinations based on the World Health Organization criteria were performed on 88 children from SOS Children?s Village in Croatia. The teeth were clinically examined with standard dental instruments using the visual-tactile method under standard light. The clinical indexes of decayed, missed, and filled (dmft and DMFT, for primary and permantnt teeth, respectively) and decayed, missed, and filled surfaces (DMFS), as well as the significant caries index (SiC) were recorded. Results. Among the children from the SOS Children?s Village caries incidence were 57.94%. The mean dmft, DMFT and DMFS of all children was 1.82, 1.90 and 2.82, respectively. The highest mean dmft and DMFT score of 4.24 and 2.56 was found among 7?10 and 11?14 years old children, respectively. The highest mean DMFS score of 3.85 and 3.90 was found among 11?14 years old children and among the children from the SOS Children?s Village Lekenik, respectively. Among all children, the SiC index was 4.69. There was a significant difference between age groups and children?s place of residence in DMFT, DMFS and SiC. Conclusion. Prevalence of dental caries is low among the children from the SOS Children?s Village in Croatia compared to the children who lived with biological families.
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Zhu, Wan Chun, Jin Xiao, Yuan Liu, Jun Wu, and JiYao Li. "Caries Experience in Individuals with Cleft Lip and/or Palate in China." Cleft Palate-Craniofacial Journal 47, no. 1 (January 2010): 43–47. http://dx.doi.org/10.1597/07-076.1.

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Objective To determine the levels of dental caries in subjects with cleft lip and/or palate in China in comparison with controls. Design A total of 380 subjects with cleft lip and/or palate and 339 noncleft control subjects were examined for dental caries using the decayed-missing-filled-teeth (DMFT/dmft) and decayed-missing-filled-surfaces (DMFS/dmfs) index. A questionnaire was used to acquire subjects' living habits and family socioeconomic status. Setting West China Stomatology Hospital, Sichuan University. Subjects Individuals between 3 and 25 years of age. Results Caries prevalence and scores for dmft/DMFT and dmfs/DMFS were significantly higher in subjects with cleft palates when compared with the noncleft control group ( p < .05), except 3- to 5-year-old children ( p > .05). However, in the 3- to 5-year-old group, children with cleft lip and/or palate had significantly more caries than children of the same age with only a cleft lip with or without alveolus ( p < .05). Children whose clefts had been surgically repaired had a lower dmft and dmfs than those whose clefts had not been surgically repaired ( p < .05). Conclusion Individuals with oral cleft are at an increased risk for dental caries. The types of cleft and the surgical repair are two important factors for dental caries.
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Guo, ShuLing, Yong Chen, Sreekanth Kumar Mallineni, ShuYing Huang, BaiWang Liu, ShuYi Zhang, and Chang Lu. "Feasibility of oral health evaluation by intraoral digital photography: a pilot study." Journal of International Medical Research 49, no. 2 (February 2021): 030006052098284. http://dx.doi.org/10.1177/0300060520982841.

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Objectives This study investigated the accuracy and duration of intraoral digital photograph examination (IDPE) for evaluating oral health status and explored the feasibility of remote oral health assessment. Methods Thirty-one healthy college students underwent evaluations of oral health status via clinical examination (CE) combined with panoramic X-ray assessment at baseline, followed by IDPE 1 month later using photos taken at baseline. Methods for evaluation of gingival health included the Modified Gingival Index (MGI) and Plaque Index (PI). Examinations of caries status included the decayed, missing, and filled teeth and surfaces indexes (DMFT and DMFS indexes, respectively). The duration of each evaluation was also recorded. Results There were significant differences in MGI and PI between CE and IDPE. There were no significant differences in DMFT and DMFS indexes between CE and IDPE, and there were positive correlations between CE and IDPE for each of the two indexes (DMFT index: r=0.56; DMFS index: r=0.69). The IDPE duration was shorter than the CE duration. Conclusions The feasibility of caries status assessment via IDPE is promising. Digital oral health evaluation merits further clinical consideration. Trial registration Xiamen University Training Program of Innovation and Entrepreneurship for Undergraduates, project number: 2018X0583. Registered 1 April 2018; http://cxw.xmu.edu.cn/admin/Innovation/NewInnovationDetail?id=6ce0a415-6131-496b-891a-6a1ae44e556d
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Cahen, P. M., J. C. Turlot, R. M. Frank, and A. M. Obry-Musset. "National Survey of Caries Prevalence in 6-15-year-old Children in France." Journal of Dental Research 68, no. 1 (January 1989): 64–68. http://dx.doi.org/10.1177/00220345890680011001.

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The prevalence of dental caries in France is not known on a nationwide basis, despite the fact that a number of epidemiological studies have been conducted in various parts of the country. The aim of the present study was to provide a national baseline examination of the dental health of children in 1987 since, beginning in November, 1986, the sale of fluoridated salt began in France. A multi-stage probability sample of 19,366 children was selected as representative of the 6-to-15-year-old population. The sample covered all the 95 departments of France. Teams of well-calibrated examiners were constituted in each of the sixteen Faculties of Dental Surgery of France. The prevalence of caries for each age group was determined by means of DMFT, DMFS, dft, and dfs indices. Periodontal conditions were assessed by means of the Plaque Index (Silness and Löe, 1964), the Calculus Index (Marthaler, 1966), and the Gingival Index (Löe and Silness, 1963). Calculation of the mean DMFT index showed, respectively, 0.5 and 1.0 new carious teeth per year under and over the age of 11. The mean values of the DMFT index at ages 6, 12, and 15 were, respectively, 0.5, 4.2, and 6.9. Under the age of 11, the mean DMFS index increased by one between each successive age group and by nearly two over the age of 11. The mean values of the DMFS index at ages 6, 12, and 15 were, respectively, 0.8, 7.6, and 13.0. The percentage of caries-free children decreased from 32.2% at age 6 to 7.9% at age 15.
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7

Ivanisevic, Zrinka, Zvonimir Uzarevic, Stjepanka Lesic, Aleksandar Vcev, and Marko Matijevic. "Oral Health of Children from the SOS Children’s Village in Croatia." International Journal of Environmental Research and Public Health 18, no. 2 (January 13, 2021): 616. http://dx.doi.org/10.3390/ijerph18020616.

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The aim of this study was to determine the values of DMFT/DMFS and dft/dfs in the examined groups of children and the assessment of the mothers of the examined groups of children related to the oral health of their children. The research included children from the SOS Children’s Village in Croatia as well as children from biological families from rural and urban areas. The children were examined by the visual–tactile method according to the standardized World Health Organization criteria. dft/DMFT and dfs/DMFS indices were calculated. An analysis of completed questionnaires was made. The children from the SOS Children’s Village demonstrated the lowest mean values of the dft/dfs (2.42/3.31) and DMFT/DMFS (1.61/2.23) indices compared to children from rural and urban areas. The Kruskal–Wallis test showed a significant difference (p = 0.01) in SiC index values between the examined children. In the groups of children from the SOS Children’s Village and from the rural area compared to the children from the urban area, oral hygiene was singled out as the most important factor in the analysis of the main components. An equally significant factor for all the respondents is the assessment of oral health and eating habits. The least significant factor for the group of children from the SOS Children’s Village is socio-economic status, which is the most significant for the children from the urban area. The children from the SOS Children’s village have the lowest dft/DMFT, dfs/DMFS, and SiC indices. The most important factor influencing oral health in the group of children from the SOS Children’s Village that stands out is oral hygiene, and the least important is the socio-economic status. The assessment of oral health by the SOS mothers does not differ from the assessment of biological mothers of children from rural and urban areas.
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Rożniatowski, Piotr, Anna Piróg-Bednarska, Angelika Kobylińska, Dariusz Gozdowski, and Dorota Olczak-Kowalczyk. "Clinical consequences of untreated early childhood caries in urban population of children with high risk of caries in Poland." Journal of Stomatology 69, no. 6 (December 31, 2016): 620–30. http://dx.doi.org/10.5604/00114553.1230582.

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Background. The anatomy and low mineral content of primary teeth, especially soon after their eruption, predispose to acute progression of caries. Untreated early childhood caries (ECC) can rapidly lead to destruction of the crown and to pulpal involvement. It is, therefore, important to depict its clinical consequences in relation to caries intensity and age. Aim of the study. To assess the correlation of clinical consequences of ECC with its intensity and age in urban population of children with high risk of caries in Poland. Material and methods. In a group of high caries risk children from Warsaw aged below 6 years the following were evaluated: dental health (decayed, filled, missing teeth due to caries (dmft/dmfs), carious pulp exposure) and mucosal health (ulcerations caused by decayed teeth, fistulae, abscesses (pufa). Four age groups were distinguished: less than 3 years, 3-4 years, 4-5 years and 5-6 years. Statistical analysis: Kruskal-Wallis test (significance level p=0.05). Results. Among 223 children (mean age 4.30±1.154 years) dmft>0 was found in 80% (mean dmft=6.14±5.49, dmfs=11.60±12.92), restorative index was 0.23±0.33. Pufa >0 was observed in 26% (mean 0.853±1.839) with the highest value in the youngest age group (mean 1.20±2.222). Correlations between dmft, dmfs and pufa were observed. Statistically significant correlations were found between teeth missing due to caries and the clinical consequences of untreated caries. Conclusions. The younger the child affected by caries, the more severe the consequences of untreated caries. It has been observed that the rate of consequences increases with caries intensity.
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Cardoso, Luciana, Lisiane Christoff Corrêa de Barros, Paulo Floriani Kramer, Cassiano Kuchenbecker Rösing, and Carolina Covolo da Costa. "Comparative analisys of three different diagnostic methods to evaluate carious activity in a community basis." Journal of Applied Oral Science 13, no. 2 (June 2005): 171–75. http://dx.doi.org/10.1590/s1678-77572005000200015.

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The present research has made a comparison between three distinct methods to evaluate carious activity in a community basis. The studied method was based in a modified DMFS/dmfs index including non-cavitated lesions. Two factors were analyzed: the possible reproduction of the inclusion of carious activity criteria and the presence of bacterial plaque. Thus, the three study groups presented with plaque, after supervised self-performed plaque removal with dental toothbrush and without plaque after professional prophylaxis, which corresponded to three diagnostic methods. The three exams took place one week apart from each other. For this analysis, a modified DMFS/dmfs index was proposed with alterations in diagnostic criteria due to the inclusion of carious activity parameters. The study was performed in a group of 30 children aged 11 years old. According to the results, the diagnostic method for carious activity in the three situations was reproducible and can be considered a proper approach to perform caries diagnosis in a community basis.
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10

Zhang, Lu-Lu, Fei Xu, Wen-Ting He, Meng-Yao Huang, Di Song, Yi-Yang Li, Qi-Ling Deng, Yong-Shi Huang, Ting Wang, and Jian-Yong Shao. "Development and validation of a prognostic nomogram for the pre-treatment prediction of early metachronous metastasis in endemic nasopharyngeal carcinoma: a big-data intelligence platform-based analysis." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592097813. http://dx.doi.org/10.1177/1758835920978132.

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Background: Early failure of cancer treatment generally indicates a poor prognosis. Here, we aim to develop and validate a pre-treatment nomogram to predict early metachronous metastasis (EMM) in nasopharyngeal carcinoma (NPC). Methods: From 2009 to 2015, a total of 9461 patients with NPC (training cohort: n = 7096; validation cohort: n = 2365) were identified from an institutional big-data research platform. EMM was defined as time to metastasis within 2 years after treatment. Early metachronous distant metastasis-free survival (EM-DMFS) was the primary endpoint. A nomogram was established with the significant prognostic factors for EM-DMFS determined by multivariate Cox regression analyses in the training cohort. The Harrell Concordance Index (C-index), area under the receiver operator characteristic curve (AUC), and calibration curves were applied to evaluate this model. Results: EMM account for 73.5% of the total metachronous metastasis rate and is associated with poor long-term survival in NPC. The final nomogram, which included six clinical variables, achieved satisfactory discriminative performance and significantly outperformed the traditional tumor–node–metastasis (TNM) classification for predicting EM-DMFS: C-index: 0.721 versus 0.638, p < 0.001; AUC: 0.730 versus 0.644, p < 0.001. The calibration curves showed excellent agreement between the predicted and actual EM-DMFS. The nomogram can stratify patients into three risk groups with distinct EM-DMFS (2-year DMFS: 96.8% versus 90.1% versus 80.3%, p < 0.001). A validation cohort supported the results. The three identified risk groups are correlated with the efficacy of different treatment regimens. Conclusion: Our established nomogram can reliably predict EMM in patients with NPC and might aid in formulating risk-adapted treatment decisions and personalized patient follow-up strategies.
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Bolsson, Gabriela Bohrer, Jessica Klöckner Knorst, Marília Cunha Maroneze, Maísa Casarin, Patrícia Pasquali Dotto, and Bianca Zimmermann Santos. "Factors influencing the dental caries in pregnant women: a cross-sectional study." Research, Society and Development 10, no. 1 (February 11, 2021): e32810111226. http://dx.doi.org/10.33448/rsd-v10i1.12226.

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Objective: To assess factors associated with the average number of dental caries in pregnant women. Method: Basic research design: This cross-sectional study was performed between January 2017 and December 2018 in Santa Maria, Brazil. Clinical setting and participants: Multistage random sampling resulted in the recruitment of 256 pregnant women from public health centers across the city. Clinical exams and semi-structured questionnaires including demographic, socioeconomic and behavioral questions were performed by trained interviewers. Main outcome measure: The experience of dental caries was evaluated through the mean value of the Decay, Missing, and Filled Surface Index (DMFS) by 4 trained and calibrated examiners. Multilevel Poisson regression models were used to evaluate the influence of different variables on the average number of dental caries. Rate ratio (RR) and respective 95% confidence intervals were calculated (CI 95%). Results: The prevalence of untreated dental caries was 62.7% in the sample, while the mean DMFS index was 10.27 (± 10.92). Women who smoked during pregnancy had a higher mean DMFS (RR 1.41; 95% CI 1.25-1.57). Furthermore, pregnant women who had poor self-ratings of oral health had a higher average DMFS (RR 1.21; 95% CI 1.10-1.32). Conclusions: The results showed that older age, ethnicity, fewer years in education and the presence of dental plaque resulted in higher means of DMFS.
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Paul, Tahir, and Ron S. Brandt. "Oral and Dental Health Status of Children with Cleft Lip and/or Palate." Cleft Palate-Craniofacial Journal 35, no. 4 (July 1998): 329–32. http://dx.doi.org/10.1597/1545-1569_1998_035_0329_oadhso_2.3.co_2.

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Objective To ascertain the oral and dental health status of children with cleft lip and/or palate. Design Oral and dental examinations were carried out on 114 selected children with cleft lip and/or palate, using standard criteria and indices. Setting These children were examined at two cleft palate clinics in the United Kingdom. Patients All children examined were between the ages of 3 and 18 years. Results Sixty one (53.5%) of the subjects exhibited no evidence of previous caries experience, but as many as 20% exhibited active decay. The mean caries experience in the deciduous dentition (dmfs) was 2.3, and that in the permanent dentition (DMFS) was 0.9. Caries experience of the Caucasian children of the sample was lower (mean dmfs 1.9) than that of the Asian children (mean dmfs 5.5). The mean simplified debris index of the sample was 0.9, and the mean gingival bleeding index was 0.4. Children with cleft lip and palate had generally poorer oral and gingival health than those with isolated clefts of the lip or palate. Conclusion Twenty percent of the sample had active decay. These children had poor oral health in the surgically repaired anterior segment.
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Sharma, Suresh, Manjit Talwar, Amrit Tewari, Harpinder Singh Chawla, and Vinod Sachdev. "Relationship of Dental Caries with Fluoride Concentration in Unstimulated whole Saliva of 7 to 15-year-old Nonfluoride Users." International Journal of Experimental Dental Science 3, no. 2 (2014): 59–62. http://dx.doi.org/10.5005/jp-journals-10029-1072.

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ABSTRACT Objective The objective of the present study was to investigate the relationship between dental caries and fluoride concentration in unstimulated whole saliva of non-fluoride users. Study design Ninety subjects, aged 7 to 15 years who were non-fluoride users, participated in the study. Dental caries was recorded using modified Moller's index. Unstimulated whole saliva samples were collected early in the morning. Fluoride concentration in saliva was estimated using combination ion specific fluoride electrode (Orion). Water fluoride of the area ranged from 0.34 to 0.38 ppm. Results Salivary fluoride concentration (mean ± SE) in saliva (n = 90) was 0.03 ± 0.03 ppm with a range of 0.01 to 0.24 ppm. The DMFT ± SE was 3.26 ± 0.27 and DMFS 4.30 ± 0.42. Correlation of fluoride concentration in saliva was inverse and significant with DMFT (p < 0.01) and DMFS (p < 0.01) using the Spearman's rank correlation coefficient. Conclusion Fluoride concentration in saliva could be an indication of the individual's caries risk and help isolating high risk individuals requiring special chairside preventive strategies. How to cite this article Talwar M, Tewari A, Chawla HS, Sachdev V, Sharma S. Relationship of Dental Caries with Fluoride Concentration in Unstimulated whole Saliva of 7 to 15-year-old Nonfluoride Users. Int J Experiment Dent Sci 2014;3(2): 59-62.
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Liubarets, Svetlana, Irina Iliyenko, Tetiana Liubarets, Olena Lyaskivska, Nataliia Bidenko, Oleksandr Savychuk, and Dymytriy Bazyka. "FEATURES OF STOMATOLOGIC STATUS, TELOMERE LENGTHS AND PHENOTYPE OF IMMUNOCOMPETENT CELLS OF PERIPHERAL BLOOD IN CHILDREN – RESIDENTS OF UKRAINIAN TERRITORIES, CONTAMINATED WITH RADIONUCLIDES." EUREKA: Health Sciences 5 (September 29, 2017): 59–68. http://dx.doi.org/10.21303/2504-5679.2017.00438.

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Objective of research. To analyze features of stomatological status indexes, relative length of telomeres and phenotype of immunocompetent cells of peripheral blood in children with chronological enamel hypoplasia – residents of Ukrainian territories, contaminated with radionuclides after the Chornobyl NPP accident. Materials and methods. The object of research is chronological enamel hypoplasia (CEH) of permanent teeth, and lymphocytes of peripheral blood (PB). The subject of research is the state of oral cavity hygiene, caries intensity, gingivitis severity degree, relative telomere length (RTL), and phenotype of immunocompetent cells (ICC) of peripheral blood (PB). Methods of the research: stomatological, immunological (flow cytofluorometry), molecular genetic (fluorescence in situ hybridization-flow cytometry – flow-FISH), statistical. Results. Two types of the analysis of the stomatologic status, RTL and phenotype of PB ICC were carried out: the first is the comparison of indexes of the combined group of children with anamnesis complicated by radiation (group No. 1 with CEH + group No. 2 without CEH) comparing with the control group No. 3; the second is the analysis of indeces of the group No. 1 comparing with the same markers in children of the groups No. 2 and No. 3. The first stage of the analysis shows thesignificant worsening of oral hygien indices , high DMFTand DMFS in children with permanent dentition, higher degree of gums inflamation and moresignificant RTL shortening in children of the combined group (No. 1 + No. 2) comparing with the control. Changes of the same character, but more expressed observed during the another analysis concerning the children with anamnesis complicated by radiation and CEH comparing with the control. Reliable changes in the content of PB ICC subpopulations in the examined children of all groups were not identified. Conclusions. 1. Inchildren with CEH, complicated by ionizing radiation (IR) influence in low doses diapason the highest degree of stomatological status disorders comparing with the examined reference and control groups was determined: unsatisfactory and poor oral cavity hygiene according to OHI-S (1.76±0.41, р˂0.0001 and р˂0.0001, respectively) and Silness-Loe index (1.73±0.45, р˂0.0001 and р˂0.0001, respectively); very high intensity of dental caries ((DMFT=7.0±2.29, р=0.003and р˂0.0001; DMFS=8.74±2.58, р=0.0004 and р˂0.0001, respectively); mean degree of gingivitis severity (РМА 47.55±14.27 %, р˂0.0001 and р˂0.0001, respectively). 2. At CEH, which occurs due to the complex of negative factors during first years of life, including IR in residents of territories with effective doses more than 1.0 mSv/year, reliable shortening of relative telomeres length of PB lymphocytes comparing with the control group (15.17±3.20, р=0.0002) was found. Reliable differences in the content of peripheral blood immunocompetent cells when compared the examined groups were not identified. 3. Results of indices of the groups No. 1, No. 2 and No. 3 comparison are agreed with the data, obtained in result of dispersive analysis that allowed to separate the most informative indices concerning stomatological examination of children: OHI-S index (F=34.92; р˂0.001); Silness-Loe index (F=27.01; р˂0.001); dft+DMFT (F=82.23; р˂0.001); dfs+DMFS (F=49.41; р˂0.001); DMFT (F=13.94; р˂0.001); DMFS(F=19.41; р˂0.001); РМА (F=41.25; р˂0.001); RTL (F=7.53; р=0.001).
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Mitropoulos, Cynthia. "DMFS(e) index for selection of clinical trial subjects." Community Dentistry and Oral Epidemiology 13, no. 1 (February 1985): 30–32. http://dx.doi.org/10.1111/j.1600-0528.1985.tb00415.x.

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Sánchez-Pérez, Leonor, Laura Patricia Sáenz-Martínez, Nelly Molina-Frechero, María Esther Irigoyen-Camacho, Marco Zepeda-Zepeda, and Enrique Acosta-Gío. "Body Mass Index and Dental Caries, a Five-Year Follow-Up Study in Mexican Children." International Journal of Environmental Research and Public Health 18, no. 14 (July 11, 2021): 7417. http://dx.doi.org/10.3390/ijerph18147417.

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There are conflicting reports on a possible association between body mass index (BMI) and caries. Given the ongoing worldwide increase in obesity, we undertook a 5-year follow-up study on 201 Mexican schoolchildren to analyse their BMI and dental caries experience. The children’s weight and height were recorded, and their BMI was calculated using the WHO tables. Decayed, missing, and filled surfaces in both dentitions (dmf/DMFS) were assessed annually according to WHO criteria by two calibrated researchers (Kappa value 0.92 p < 0.001). The means, standard deviation, an ANOVA, and Student’s t-test were calculated to analyse the relationship between the variables. At baseline, the children had an average of 6.5 ± 0.5 years, a BMI of 17.2 ± 3.1 (CI95% 16.8–17.6). Their weight’s classifications were 61% normal, 19% obese, 17% overweight, and 3% showed thinness. At the end of the study, their BMI were 20.6 ± 4.4 (CI95% 19.8–21.5), 53% normal, 15% obese, 30% overweight, and 2% thin. The children’s dmfs decreased from 5.8 ± 9.2 to 1.8 ± 3.4 and the DMFS increased from 0.07 ± 05 to 1.4 ± 2.3. In this population based on a 5-year follow-up, caries prevalence and incidence were not significantly associated with the BMI. However, schoolchildren with malnutrition had the highest caries indexes.
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Peres, M. A., X. Ju, M. Mittinty, A. J. Spencer, and L. G. Do. "Modifiable Factors Explain Socioeconomic Inequalities in Children’s Dental Caries." Journal of Dental Research 98, no. 11 (August 3, 2019): 1211–18. http://dx.doi.org/10.1177/0022034519866628.

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The aim of this article was to quantify socioeconomic inequalities in dental caries experience among Australian children and to identify factors that explain area-level socioeconomic inequalities in children’s dental caries. We used data from the National Child Oral Health Survey conducted in Australia between 2012 and 2014 ( n = 24,664). Absolute and relative indices of socioeconomic inequalities in the dental caries experience in primary and permanent dentition (decayed, missing, and filled surfaces [dmfs] and DMFS, respectively) were estimated. In the first stage, we conducted multilevel negative binomial regressions to test the association between area-level Index of Relative Socioeconomic Advantage and Disadvantage (IRSAD) and dental caries experience (dmfs for 5- to 8-y-olds and DMFS for 9- to 14-y-olds) after adjustment for water fluoridation status, sociodemographics, oral health behaviors, pattern of dental visits, and sugar consumption. In the second stage, we performed Blinder-Oaxaca and Neumark decomposition analyses to identify factors that explain most of the area-level socioeconomic inequalities in dental caries. Children had a mean dmfs of 3.14 and a mean DMFS of 0.98 surfaces. Children living in the most disadvantaged and intermediately disadvantaged areas had 1.96 (95% confidence interval, 1.69–2.27) and 1.45 (1.26–1.68) times higher mean dmfs and 1.53 (1.36–1.72) and 1.43 (1.27–1.60) times higher mean DMFS than those living in the most advantaged areas, respectively. Water fluoridation status (33.6%), sugar consumption (22.1%), parental educational level (14.2%), and dental visit patterns (12.7%) were the main factors explaining area-level socioeconomic inequalities in dental caries in permanent dentition. Among all the factors considered, the factors that contributed most in explaining inequalities in primary dental caries were dental visits (30.3%), sugar consumption (20.7%), household income (20.0%), and water fluoridation status (15.9%). The inverse area-level socioeconomic inequality in dental caries was mainly explained by modifiable risk factors, such as lack of fluoridated water, high sugar consumption, and an unfavorable pattern of dental visits.
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Gerreth, Piotr, Karolina Gerreth, Mateusz Maciejczyk, Anna Zalewska, and Katarzyna Hojan. "Is an Oral Health Status a Predictor of Functional Improvement in Ischemic Stroke Patients Undergoing Comprehensive Rehabilitation Treatment?" Brain Sciences 11, no. 3 (March 7, 2021): 338. http://dx.doi.org/10.3390/brainsci11030338.

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The study’s aim was a clinical observation concerning the influence of oral health on functional status in stroke patients undergoing neurorehabilitation. This pilot cross-sectional clinical study was performed in 60 subacute phase stroke patients during 12 weeks of treatment. The program was patient-specific and consisted of neurodevelopmental treatment by a comprehensive rehabilitation team. The functional assessment was performed using the Barthel index (BI), Berg balance scale (BBS), functional independence measure (FIM), and Addenbrooke’s cognitive examination III (ACE III) scales. Oral health was assessed according to World Health Organization (WHO) criteria, and it was presented using DMFT, DMFS, gingival index (GI), and plaque index (PlI). Significant improvement in many functional scales was noticed. However, important differences in most dental parameters without relevant changes in GI and PlI after the study were not observed. Reverse interdependence (p < 0.05) was shown between physical functioning (BI, FIM, or BBS) with GI and PlI results, and most dental parameters correlated with ACE III. Using multivariate regression analysis, we showed that ACE III and BI are predictive variables for DMFT, just as FIM is for DS (p < 0.05). The present research revealed that poor oral health status in patients after stroke might be associated with inpatient rehabilitation results.
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Shi, Yujie, Yue Zhang, Yaling Niu, Yingjie Chen, and Changgui Kou. "Prognostic role of the prognostic nutritional index (PNI) in patients with head and neck neoplasms undergoing radiotherapy: A meta-analysis." PLOS ONE 16, no. 9 (September 14, 2021): e0257425. http://dx.doi.org/10.1371/journal.pone.0257425.

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Background This novel meta-analysis was conducted to systematically and comprehensively evaluate the prognostic role of the pretreatment PNI in patients with head and neck neoplasms (HNNs) undergoing radiotherapy. Methods Three databases, PubMed, Embase, and Web of Science, were used to retrieve desired literature. Hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted and pooled by fixed-effects or random-effects models to analyze the relationship between the PNI and survival outcomes: overall survival (OS), distant metastasis-free survival (DMFS), and progression-free survival (PFS). Results Ten eligible studies involving 3,458 HNN patients were included in our analysis. The robustness of the pooled results was ensured by heterogeneity tests (I2 = 22.6%, 0.0%, and 0.0% for OS, DMFS, and PFS, respectively). The fixed-effects model revealed a lower pretreatment PNI was significantly related to a worse OS (HR = 1.974; 95% CI: 1.642–2.373; P<0.001), DMFS (HR = 1.959; 95% CI: 1.599–2.401; P<0.001), and PFS (HR = 1.498; 95% CI: 1.219–1.842; P<0.001). The trim-and-fill method (HR = 1.877; 95% CI: 1.361–2.589) was also used to prove that the existing publication bias did not deteriorate the reliability of the relationship. Conclusion The pretreatment PNI is a promising indicator to evaluate and predict the long-term prognostic survival outcomes in HNN patients undergoing radiotherapy.
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Loyola-Rodriguez, Juan Pablo, Rita Elizabeth Martinez-Martinez, Blanca Irma Flores-Ferreyra, Nuria Patiño-Marin, Angel Gabriel Alpuche-Solis, and Juan Francisco Reyes-Macias. "Distribution of Streptococcus mutans and Streptococcus sobrinusin Saliva of Mexican Preschool Caries-free and Caries-active Children by Microbial and Molecular (PCR) Assays." Journal of Clinical Pediatric Dentistry 32, no. 2 (December 1, 2007): 121–26. http://dx.doi.org/10.17796/jcpd.32.2.cm00062530v856r4.

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The aim of the study was to investigate the distribution of mutans streptococci (MS) infection of caries-free(CF) and caries-active (CA) preschool Mexican children by microbial and molecular assays. Eighty preschool children were divided into two groups, 40 CF and 40 CA children. Saliva samples were inoculated onto MSB to identify CFU and DNA extractions were tested by PCR. Our results indicated that there was no statistical difference (p&gt;0.05) between groups either in age, weight, height or sex. S. sobrinus was detected by PCR twice as much in the CA group, the difference being statistically significant (p&lt;0.05). dmfs index was positive correlated with S. mutans (r=0.2941, p=0.0081), S. sobrinus (r=0.3384, p=0.0021) and S. mutans-S. sobrinus (r=0.3978, p=0.0003). ANCOVA revealed that dmfs index had a significant effect on the distribution of CFU of S. mutans (p=0.0118) and S. sobrinus (p=0.03). When MSB was compared with PCR to identify MS, there was no statistical difference (p&gt;0.05). We conclude that S. mutans and S. sobrinus were isolated in higher numbers from CA children and those harbouring both bacteria had higher dmfs scores. PCR is a useful tool in molecular epidemiology for dental caries studies; it was effective in detecting and identifying MS from saliva in children.
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Almaas, Jenan O., and Ban S. Diab. "The impact of caries experience on quality of life among dental students in Iraq." Journal of Baghdad College of Dentistry 32, no. 3 (September 15, 2020): 8–13. http://dx.doi.org/10.26477/jbcd.v32i3.2894.

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Background: Dental caries is generally given the highest priority in national oral health services for adult populations. Yet, there is no study which has explored the impact on quality of life specifically related to dental caries in samples of dental students. The purpose of the current study was to assess the impact of caries experience on quality of life among dental students in three governorates in Iraq. Materials and Methods: This observational study included 1364 dental students aged 18–22 years old, from three governorates. Information on quality of life was obtained from a structured, self-administered questionnaire from the students who were willing to participate in the study. The data was collected, summarized and statistically analyzed. Caries experience in the present study was determined by the Decayed- Missing Filled Surfaces (DMFS) indexed by WHO in 1997 in which all teeth were examined and all the third molars were included. Results: Regarding dental caries and the four Quality of Life domains, in each domain scores, DS component had the highest contribution to the DMFS followed by the MS component while FS components had the lowest contribution to the index. On the other hand, DMFS showed the lowest mean among the good scores of all domains and it had the highest mean among the poor type. Conclusion: The quality of life among dental students is associated with caries severity as the DMFS and its components affected different domains regarding quality of life.
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Hassan, Dr Dhuha M., and Dr Baydaa Hussien Hussien. "Oral health status in relation to nutritional status among kindergarten children aged (4-5) years old in Karbala city / Iraq." Mustansiria Dental Journal 14, no. 1 (January 4, 2019): 72. http://dx.doi.org/10.32828/mdj.v14i1.762.

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Back ground: Dental caries and periodontal disease were the most common andwidely spread diseases affecting children. The nutrition may be one of the factorsaffecting the severity of the oral diseases. The Aims of this study was theassessment of the following oral diseases (dental caries, gingivitis) in addition toassessment of oral hygiene among 4-5 years old children in Karbala city –Iraq.Furthermore, nutritional status was assessed in relation to oral diseases.Materials and methods: A sample of 658 children (350 males, 308 females) agedfour and five years old was selected randomly from the fourteenth kindergartensin Karbala city. Diagnosis and recording of dental caries was followed the criteriaof WHO 1987. Dental plaque was assessed using plaque index of Silness and Loe,1964. Gingival health condition was assessed using gingival index of Loe andSilness, 1963. The assessment of nutritional status was performed usinganthropometric measurement (height and weight) according to Body mass indexindicator with -2SD cutoff point.Results: Caries prevalence was found to be (83%) of the total sample the mean rankvalue of dmfs was higher among boys in comparison to girls with statistically nosignificant difference (P>0.05). The value of dmfs increased with age withstatistically highly significant difference (p<0.01).The mean rank values of dentalplaque and gingival indices for total boys were found to be higher than total girlswith statistically highly significant differences (P<0.01). Recording of this studydemonstrated that 100% of children had dental plaque and gingival inflammation.Positive highly significant correlations were recorded between dental caries withdental plaque and gingival indices. The prevalence of malnutrition described byBody mass index indicator was (3.2%). According to nutritional status indicatorBody mass index-for-age, it was found that the wasted children had higher valueof dmfs than well nourished children with statistically no significant differences(P>0.05). The plaque and gingival indices were higher among well nourishedchildren than among wasted children with statistically highly significantdifferences (P<0.01).The correlation coefficient between body mass index withdental caries, plaque index and gingival index were very weak and statistically notsignificant (p>0.05).Conclusions: High prevalence of dental caries and gingivitis was recorded indicatingthe need of public and preventive programs among kindergarten children.
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Rahiotis, Chris, Panagiotis Mitropoulos, and Afrodite Kakaboura. "Comparative Evaluation of Chair-Side Saliva Tests According to Current Dental Status in Adult Patient." Dentistry Journal 9, no. 1 (January 19, 2021): 10. http://dx.doi.org/10.3390/dj9010010.

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Background: this cross-sectional study evaluated the correlation of commercial chair-side saliva tests with caries status in adults. Methods: teeth in 87 adults (20–40 years old) were clinically examined for carious lesions according to International Caries Detection and Assessment System (ICDAS) criteria. The Decayed-Missing-Filling-Tooth (DMFT) and Decayed-Missing-Filling-Surface (DMFS) indexes at D1 (lesions 1–6 according to ICDAS criteria) and D3 (lesions 4–6 according to ICDAS criteria threshold and the number of active lesions, according to the Lesion Activity Assessment (LAA)) criteria were measured. The saliva parameters measured by chair-side tests were stimulated and non-stimulated saliva flow rate, saliva consistency, saliva pH, saliva buffer capacity, and lactic acid production. The statistical analyses performed were Student t-test and Mann–Whitney U test at a = 0.05 significant level. Results: the low resting saliva pH was related to a high value of DMFT (D1) index (p = 0.007). Conclusions: among the saliva parameters measured, the values of low resting pH are associated with increased DMFT at threshold D1. None of the chair-side available saliva tests evaluated can accurately underline the tooth carious status.
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Nirunsittirat, Areerat, Waranuch Pitiphat, Christy M. McKinney, Timothy A. DeRouen, Nusara Chansamak, Onauma Angwaravong, Piyachat Patcharanuchat, and Taksin Pimpak. "Breastfeeding Duration and Childhood Caries: A Cohort Study." Caries Research 50, no. 5 (2016): 498–507. http://dx.doi.org/10.1159/000448145.

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This cohort study was conducted in Khon Kaen, Thailand, to test the hypothesis that a longer breastfeeding duration increases the risk for dental caries in primary teeth. We collected information on infant feeding practices and potential confounders using a structured questionnaire to interview mothers or caregivers during the second trimester of pregnancy and after birth at 21 days and at 3, 12, 18, 24, and 36 months. Regardless of other liquids and foods, full breastfeeding was defined as feeding breast milk but not formula, while any breastfeeding was feeding breast milk with or without formula. Two calibrated dentists measured dental caries when the children were 3-4 years of age using the decayed, missing, and filled surfaces (dmfs) index following the World Health Organization criteria. Negative binomial regression with a generalized linear model was used to estimate relative risks (RRs) and 95% confidence intervals (CIs) using dmfs as an outcome. Log-binomial regression was performed to model the caries prevalence. Of 556 children, 88.1% had dental caries with a mean dmfs of 14.2. Full breastfeeding for 6-11 months was significantly associated with a lower dmfs (adjusted RR 0.77, 95% CI 0.63, 0.93) and a lower caries prevalence (adjusted RR 0.45, 95% CI 0.22, 0.90). The frequency of sleeping while breast- or bottle-feeding increased the caries risk in a dose-response manner. There was no association between duration of any breastfeeding and dental caries. In conclusion, full breastfeeding for 6-11 months may protect against dental caries in primary teeth. Prolonged breastfeeding was not associated with dental caries in this population.
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Ancuta, Codrina, Cristina Angela Ghiorghe, Rodica Chirieac, Alice Arina Ciocan Pendefunda, and Cristina Iordache. "Specific Sialochemical and Sialometric Changes and Cariogenic Risk in Patients with Primary Sjogren`s Syndrome." Revista de Chimie 68, no. 9 (October 15, 2017): 2135–38. http://dx.doi.org/10.37358/rc.17.9.5841.

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The main aim of our study was to perform a biochemical analysis of the saliva and to assess potential impact on oral health, particularly cariogenic issues, in patients with salivary secretory dysfunction such as primary Sjogren�s syndrome (pSSj). Consecutive pSSj and healthy age-matched controls were prospectively assessed for (i) whole saliva flow rates (unstimulated, RFR, and stimulated, RFS), pH and composition; (ii) cariogenic scores - decayed, missing and filled tooth surfaces (DMFS index), Silnes and Loe bacterial plaque index (PI). Salivary flow rates were significantly lower in pSSj for both unstimulated and stimulated tests (p[0.05), with a drop in pH as compared to healthy controls (p[005). Abnormal inorganic and organic saliva composition was reported in all cases comprising higher sodium, lower potassium and chloride concentrations, higher amylase activity and lower total protein (p[0.05). Statistically significant higher cariogenic scores particularly DMFS, were demonstrated in all pSSj (p[0.05). In conclusion, patients with pSSj are at increased risk to develop cariogenic issues due to both quantitative and qualitative salivary changes.
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dos Santos Pinto, Gabriela, Luciana de Ávila Quevedo, Marcos Britto Correa, Marina Sousa Azevedo, Marília Leão Goettems, Ricardo Tavares Pinheiro, and Flávio Fernando Demarco. "Maternal Depression Increases Childhood Dental Caries: A Cohort Study in Brazil." Caries Research 51, no. 1 (November 30, 2016): 17–25. http://dx.doi.org/10.1159/000449040.

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Aim: To investigate the relationship between maternal depression and childhood caries in a cohort of adolescent mothers. Methods: This cross-sectional study nested in a cohort evaluated a sample of 538 mother/child dyads. When the children were 24-36 months of age, data regarding oral health from children and mothers were collected by clinical dental examination. A mother's major depressive disorder was assessed by using the Mini International Neuropsychiatric Interview (MINI [Plus]), at the current moment. Independent variables were obtained by using questionnaires. The outcome on dental caries experience was dichotomized by using 2 cut points: dmfs ≥1 and dmfs ≥3. Poisson regression analysis, using a hierarchical approach, was applied to assess the association between major depressive disorder in mothers with and those without caries experience and the outcome. Results: The prevalence of dental caries in children was 15.1% (n = 82). The mean dmfs index was 1.12 (SD = 3.72). The prevalence of major depressive disorder was 32.6% (n = 168). An interaction between caries status and depressive disorder was found, and after adjusted analysis, children from mothers with major depressive disorder with negative caries experience presented a higher caries prevalence (prevalence ratio 4.00, 95% confidence interval 1.29-12.41). Conclusion: Our findings suggest that maternal psychiatric disorders could have a negative impact on children's oral health.
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Topkan, Erkan, Yurday Ozdemir, Ahmet Kucuk, Ozan Cem Guler, Ahmet Sezer, Ali Ayberk Besen, Huseyin Mertsoylu, et al. "Low Advanced Lung Cancer Inflammation Index Predicts Poor Prognosis in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Definitive Concurrent Chemoradiotherapy." Journal of Oncology 2020 (October 6, 2020): 1–10. http://dx.doi.org/10.1155/2020/3127275.

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Purpose. We aimed to retrospectively investigate the prognostic worth of pretreatment advanced lung cancer inflammation index (ALI) in locally advanced nasopharyngeal carcinoma (LA-NPC) patients treated with concurrent chemoradiotherapy (C-CRT). Patients and Methods. A total of 164 LA-NPC patients treated with cisplatinum-based definitive C-CRT were included in this retrospective cohort analysis. The convenience of ideal pre-C-CRT ALI cut-offs affecting survival results was searched by employing the receiver operating characteristic (ROC) curve analyses. The primary endpoint was the link between the ALI groups and overall survival (OS), while cancer-specific survival (CSS), locoregional progression-free survival [LR(PFS)], distant metastasis-free survival (DMFS), and PFS comprised the secondary endpoints. Results. The ROC curve analyses distinguished a rounded ALI cut-off score of 24.2 that arranged the patients into two cohorts [ALI ≥ 24.2 (N = 94) versus < 24.2 (N = 70)] with significantly distinct CSS, OS, DMFS, and PFS outcomes, except for the LRPFS. At a median follow-up time of 79.2 months (range: 6–141), the comparative analyses showed that ALI < 24.2 cohort had significantly shorter median CSS, OS, DMFS, and PFS time than the ALI ≥ 24.2 cohort ( P < 0.001 for each), which retained significance at 5- ( P < 0.001 ) and 10-year ( P < 0.001 ) time points. In multivariate analyses, ALI < 24.2 was asserted to be an independent predictor of the worse prognosis for each endpoint ( P < 0.001 for each) in addition to the tumor stage (T-stage) ( P < 0.05 for all endpoints) and nodal stage (N-stage) ( P < 0.05 for all endpoints). Conclusion. As a novel prognostic index, the pretreatment ALI < 24.2 appeared to be strongly associated with significantly diminished survival outcomes in LA-NPC patients treated with C-CRT independent of the universally recognized T- and N-stages.
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Yao, Ji-Jin, Ya-Nan Jin, Zhi-Gang Liu, Qiao-Dan Liu, Xiao-Feng Pei, Huai-Li Zhou, Wang-Jian Zhang, et al. "Do all patients with advanced N-stage nasopharyngeal carcinoma benefit from the addition of induction chemotherapy to concurrent chemoradiotherapy?" Therapeutic Advances in Medical Oncology 11 (January 2019): 175883591983386. http://dx.doi.org/10.1177/1758835919833863.

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Background: The aim of this study was to evaluate the benefits from the addition of induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) in N2-3 nasopharyngeal carcinoma (NPC). Methods: A total of 3089 patients with nonmetastatic NPC, staged as N2-3 were retrospectively reviewed. IC contained cisplatin (80 mg/m2) with 5-fluorouracil (800 mg/m2/day over 120 h), or cisplatin (80 mg/m2) with docetaxel (80 mg/m2), or cisplatin (60 mg/m2) with 5-fluorouracil (600 mg/m2 over 120 h), and docetaxel (60 mg/m2) administered at 3-week intervals for two or three cycles. Concurrent chemotherapy consisted of cisplatin (80 or 100 mg/m2) given in weeks 1, 4, and 7 of radiotherapy, or cisplatin (40 mg/m2) given weekly during radiotherapy. Overall, three well-matched risk groups (low, intermediate, and high risk) were created using propensity score matching, and IC plus CCRT was compared with CCRT in each risk group. Our primary endpoint was distant metastasis-free survival (DMFS). Results: A nomogram for DMFS was established with good prognostic accuracy (C-index, 0.69; 95% confidence interval, 0.64–0.73). The survival curves for low, intermediate, and high-risk groups stratified by the nomogram were significantly different between all three risk groups, with corresponding 5-year DMFS rates of 90.7%, 79.4%, and 64.9%, respectively ( p < 0.001). IC plus CCRT was significantly associated with superior DMFS as compared with CCRT alone (69.5% versus 56.7%, p = 0.004) in the high-risk group. However, no significant difference between IC plus CCRT and CCRT was observed ( p = 0.831 and 0.608, respectively) in the intermediate and low-risk groups. Conclusions: Our findings can help accurately guide the treatment of individual patients with advanced N-stage NPC.
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Ngoenwiwatkul, Yaowaluk, and Niramon Leela-adisorn. "Effects of Dental Caries on Nutritional Status Among First-Grade Primary School Children." Asia Pacific Journal of Public Health 21, no. 2 (February 4, 2009): 177–83. http://dx.doi.org/10.1177/1010539509331787.

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The aim of this study was to explore association between caries prevalence and nutritional status among first-grade primary school children. A cross-sectional study of 212 students was conducted. All students were weighed and measured and then the body mass index (BMI) was calculated. Each student underwent dental examination and was interviewed. Overall, caries prevalence was 80.2% and the average decayed, missing, and filled surfaces (dmfs) were 12.4 ± 12.3. Although none of the students was in the underweight category, 45.8% were in low percentile (5th < BMI-for-age < 15th). Multiple logistic regression showed that each extra carious surface (dmfs) increased the odds of being at risk for underweight (5th < BMI-for-age < 15th) by 3.1% after adjusting for gender and dental visits. Our findings stressed that caries has significant implications on overall child health and health personnel should increase awareness of negative impacts and promote healthy nutritional choices for children.
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Lin, Chao, Xue-Song Sun, Sai-Lan Liu, Xiao-Yun Li, Nian Lu, Xin-Ling Li, Lin-Quan Tang, and Ling Guo. "Establishment and Validation of a Nomogram for Nasopharyngeal Carcinoma Patients Concerning the Prognostic Effect of Parotid Lymph Node Metastases." Cancer Research and Treatment 52, no. 3 (July 15, 2020): 855–66. http://dx.doi.org/10.4143/crt.2019.772.

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Purpose The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of PLN metastasis and develop a nomogram for estimating individual risk.Materials and MethodsClinical data of 7,084 non-metastatic NPC patients were retrospectively reviewed. Overall survival (OS) was the primary endpoint. A nomogram was established based on the Cox proportional hazards regression model. The accuracy and calibration ability of this nomogram was evaluated by C-index and calibration curves with bootstrap validation.ResultTotally, 164/7,084 NPC patients (2.3%) presented with PLNs. Multivariate analyses showed that PLN metastasis was a negative prognostic factor for OS, progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS). Patients with PLN metastasis had a worse prognosis than N3 disease. Five independent prognostic factors were included in the nomogram, which showed a C-index of 0.743. The calibration curves for probability of 3- and 5-year OS indicated satisfactory agreement between nomogram-based prediction and actual observation. All results were confirmed in the validation cohort.ConclusionNPC patient with PLN metastasis had poorer survival outcome (OS, PFS, DMFS, and LRFS) than N3 disease. We developed a nomogram to provide individual prediction of OS for patients with PLN metastasis.
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Zeng, Yinduo, Qian Li, Jiannan Wu, Heran Deng, Ying Wang, Wenjing Wu, Jianli Zhao, et al. "A novel approach for 21-genes testing associated with prognosis in Chinese patients with ER-positive/HER2-negative breast cancer: A real-world study." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e12528-e12528. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e12528.

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e12528 Background: We previously reported a Chinese version of 21-genes Recurrence Score (RS) provides reduction chemotherapy prescription in patients with ER-Positive/HER2-Negative node negative breast cancer, while Oncotype Dx was hardly to be reached. However, the impact on clinical outcome was not mentioned. Herein, we explored whether this 21-genes recurrence score (RS) impacted on prognosis in patients with this molecular subtype of breast cancer. Methods: From Jan 2013 to Aug 2018, 378 patients with ER-Positive/HER2-Negative early stage breast cancer were enrolled. All patients received a Chinese version of 21-genes RS test, which is a new method using RNA extracted from formalin-fixed paraffin-embedded tissue performed by SurExam Campany, Guangzhou, China. . The RS score for each patient was calculated based on expression level of 21-genes used in a prosperctively defined algorithm and calculate a recurrence score range from 0 to 100 and divided three risk groups according to TAILORs study.Distant metastases-free survival (DMFS) were correlated with the 21-genes RS by Kaplan-Meier (log-rank method), and Cox regression. Multivariable logistic regression was performed to determine factors correlated with RS testing and receipt of a high-risk RS. Results: Median patient age was 46 years (18 to 77 years). The Chinese version of 21-gene RS was generated for 378 patients: 61 (16.1%) low risk ( < 11), 241 (63.8%) intermediate risk (11 to 25), and 76 (20.1%) high risk (≥ 26). At a median follow-up of 40 months, the 4-year-rate of estimated DMFS was 100%, 98.7% and 92.9% in low risk, intermediate risk and high risk groups. Meanwhile, there was no difference in RFS among three risk groups. For all patients, 21-gene RS was associated with DMFS ( P = .021). In multivariable Cox regression models, 21-gene RS was independently prognostic factor of DMFS (hazard ratio, 5.375; 95% CI, 1.00 to 28.84; P = .05). Tumor size (>2cm vs ≤2cm, OR = 2.31, P = .005), high grade ( OR = 2.15, P = .013), ki67 index ( > 14% vs ≤14%, OR = 4.24, P = .002), progesterone receptor expression ( < 20% vs ≥20%, OR = 5.07, P < .001) were predictor of high risk of RS. Conclusions: The Chinese version of 21-genes RS is independently prognostic factor for DMFS patients with ER–positive/HER2-negative node negative breast cancer. Future study was needed to explore the impact of 21 gene RS on long-term prognosis.
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Gudkina, Jekaterina, Bennett T. Amaechi, Stephen H. Abrams, Anda Brinkmane, and Ieva Jelisejeva. "Caries Increment and Oral Hygiene Changes in 6- and 12-Year-Old Children in Riga, Latvia: A 3–Year Follow–Up Report Using ICDAS II and RADKE Criteria." European Journal of Dentistry 13, no. 03 (July 2019): 413–19. http://dx.doi.org/10.1055/s-0039-1700250.

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Abstract Objectives The purpose of this study was to investigate the caries increment and oral hygiene changes over a 3-year period and also compare the sensitivity and specificity of Radke’s caries assessment method to ICDAS II among 6- and 12-year-old children in Riga, Latvia. Materials and Methods Thirty-eight 6 and thirty-nine 12-year-old children were examined visually and with bitewing (BW) radiographs for dental caries at baseline and after a 3-year period. Decayed, missing, and filled surfaces (dmfs/DMFS) in all teeth were scored by one calibrated examiner using the Radke’s caries scoring criteria. Oral hygiene level was determined using Green-Vermillion index (G-V ind.) at baseline and after 3 years. ICDAS II was used to assess all children only at the 3rd-year time point. The parents of the 6- and 12-year-old children responded to a questionnaire on oral hygiene at baseline and at the 3-year mark. Statistical Analysis The data were analyzed using t-test, Chi-square test, Wilcoxon test (α= 0.05), and sensitivity and specificity tests. Results The mean (SD) values of G–V ind. and caries experience at baseline/3-year period in 6- versus 12-year-old children were as follows. G-V ind.: 1.14(0.80) /1.48(0.89) [p = 0.4768] versus 0.99(0.45)/1.45(1.22) [p = 0.0337]. DMFS: 0.72(1.02)/ 3.13(3.13) [p = 0.0000] versus 6.79(5.14)/14.79(9.86)[p = 0.0000]; dmfs: 11.26(8.71)/7.74 (4.86) [p = 0.0780] versus 3.57 (2.03)/1.5(0.71)[p = 0.3173].The sensitivity and specificity of Radke to ICDAS II of caries-affected surfaces was: in proximal surfaces–0.57 and 0.98, on occlusal surfaces–0.83 and 0.98, on buccal/lingual surfaces–0.43 and 0.99. Conclusions The result of the present study suggests that the increased caries experience over a 3-year period among the 6- and 12-year-old children in Riga may be due to the concurrent decreased level of oral hygiene, suggesting that ICDAS II instead of Radke’s criteria should be used to detect and monitor dental caries.
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Turska-Szybka, Anna, Urszula Kaczmarek, Dariusz Gozdowski, Jacek Tomczyk, and Dorota Olczak-Kowalczyk. "Trends in caries experience and background factors in 3-year-old children in Poland: evidence from epidemiological surveys during 2002-2017." Anthropological Review 82, no. 1 (March 1, 2019): 79–90. http://dx.doi.org/10.2478/anre-2019-0006.

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Abstract The prevalence of early childhood caries and its level varies. The present study was to establish the trends in dental caries and the impact of behavioural changes on the prevalence of caries in three-yearolds in Poland within a fifteen-year period. The results of a cross sectional survey carried out on 3439 three-year-olds in 2002, 2009, and 2017 using WHO criteria for dental caries (dmft, dmft=0, dmft≥4) and the results of a questionnaire filled by their parents with data on sociodemographics, oral hygiene and dietary habits, especially their sugar intake, were assessed. The dmft/dmfs index is applied to the primary dentition and is expressed as the total number of teeth/surfaces that are decayed, missing, or filled. The Cochran-Armitage test for trend was used to assess the fraction changes in time. The Pearson correlation coefficient was used to assess the changes in dmft trends and the correlations between behavioural changes, awareness levels, and the prevalence of caries. Within the fifteen-year period minimal changes in the prevalence of early childhood caries (15% down), dmft≥4 (11.4% down) and a lower dmft (36% down) were accompanied by a better parent awareness about the causes of caries and better oral hygiene routines. Sugary beverages were no longer drank at least once a day, however sweetened milk, cake, doughnuts, and sweet rolls were consumed more often. Being female, living in an urban area, having parents more aware about caries, consuming sugary beverages less frequently, brushing teeth twice a day, and using a fluoride toothpaste promoted lower early childhood caries. Gradually healthier teeth are linked to an increased awareness of the parents and healthier routines. A too frequent exposure to sugar promotes early childhood caries. Should the changes of dietary habits be insufficient, brushing teeth with fluoride toothpaste becomes crucial.
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Liu, Li-Ting, Yu-Jing Liang, Shan-Shan Guo, Hao-Yuan Mo, Ling Guo, Yue-Feng Wen, Hao-Jun Xie, et al. "Induction chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in the treatment of different risk locoregionally advanced nasopharyngeal carcinoma." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592092821. http://dx.doi.org/10.1177/1758835920928214.

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Background: This study aimed to investigate the efficiency and toxicities of concurrent chemoradiotherapy (CCRT) and induction chemotherapy (IC) followed by radiotherapy (RT) in different risk locoregionally advanced nasopharyngeal carcinoma (NPC). Methods: A total of 1814 eligible patients with stage II–IVB disease treated with CCRT or IC plus RT were included. The overall survival (OS), progression-free survival (PFS) and distant metastasis-free survival (DMFS) were calculated using the Kaplan–Meier method, and the differences were compared using the log-rank test. Results: Nomograms were developed to predict OS, PFS and DMFS (C-index: 0.71, 0.70 and 0.71, respectively). Patients were then divided into three different risk groups based on the scores calculated by the nomogram for OS. In the low and intermediate-risk group, no significant survival differences were observed between patients treated with IC plus RT alone and CCRT (5-year OS, 97.3% versus 95.6%, p = 0.642 and 87.6% versus 89.7%, p = 0.381, respectively; PFS, 95.9% versus 95.6%, p = 0.325 and 87.6% versus 89.0%, p = 0.160, respectively; DMFS, 97.2% versus 94.8%, p = 0.339 and 87.2% versus 89.3%, p = 0.628, respectively). However, in the high-risk group, IC plus RT displayed an unfavorable 5-year OS (71.0% versus 77.2%, p = 0.022) and PFS (69.4.0% versus 75.4%, p = 0.019) compared with CCRT. A significantly higher incidence of grade 3 and 4 adverse events was documented in patients treated with CCRT than in those treated with IC plus RT in all risk groups ( p = 0.040). Conclusion: IC followed by RT represents an alternative treatment strategy to CCRT for patients with low and intermediate-risk NPC, but it is not recommended for patients with high-risk NPC.
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Rouzier, Roman, Lajos Pusztai, Suzette Delaloge, Ana M. Gonzalez-Angulo, Fabrice Andre, Kenneth R. Hess, Aman U. Buzdar, et al. "Nomograms to Predict Pathologic Complete Response and Metastasis-Free Survival After Preoperative Chemotherapy for Breast Cancer." Journal of Clinical Oncology 23, no. 33 (November 20, 2005): 8331–39. http://dx.doi.org/10.1200/jco.2005.01.2898.

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Purpose To combine clinical variables associated with pathologic complete response (pCR) and distant metastasis–free survival (DMFS) after preoperative chemotherapy (PC) into a prediction nomogram. Patients and Methods Data from 496 patients treated with anthracycline PC at the Institut Gustave Roussy were used to develop and calibrate a nomogram for pCR based on multivariate logistic regression. This nomogram was tested on two independent cohorts of patients treated at the M.D. Anderson Cancer Center. The first cohort (n = 337) received anthracycline; the second cohort (n = 237) received a combination of paclitaxel and anthracycline PC. A separate nomogram to predict DMFS was developed using Cox proportional hazards regression model. Results The pCR nomogram based on clinical stage, estrogen receptor status, histologic grade, and number of preoperative chemotherapy cycles had good discrimination and calibration in the training and the anthracycline-treated validation sets (concordance indices, 0.77, 0.79). In the paclitaxel plus anthracycline group, when the predicted pCR rate was less than 14%, the observed rate was 7.5%; for a predicted rate of ≥ 38%, the actual rate was 85%. For a predicted rate between 14% to 38%, the observed rates were 50% with weekly and 27% with 3-weekly paclitaxel. This indicates that patients with intermediate chemotherapy sensitivity benefit the most from the optimized schedule of paclitaxel. Patients unlikely to achieve pCR to anthracylines remain at low probability for pCR, even after inclusion of paclitaxel. The nomogram for DMFS had a concordance index of 0.72 in the validation set and outperformed other prediction tools (P = .02). Conclusion Our nomograms predict pCR accurately and can serve as a basis to integrate future molecular markers into a clinical prediction model.
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Bagramian, R. A., S. Narendran, and M. Ward. "Relationship of Dental Caries and Fluorosis to Fluoride Supplement History in a Non-Fluoridated Sample of Schoolchildren." Advances in Dental Research 3, no. 2 (September 1989): 161–67. http://dx.doi.org/10.1177/08959374890030021501.

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A random sample of 206 Michigan children, aged from 9 to 13, were examined for fluorosis from a larger group of 2038 children participating in a dental project. Clinical examinations included caries data (DMFS) and assessment of fluorosis by use of the Tooth Surface Index of Fluorosis (TSIF). Separate examiners were used for each index. The response rate of a questionnaire mailed to parents to gather information on residence histories, use of fluoride supplements, and antibiotics was 78%. The prevalence of fluorosis was about 20% among the respondents. Of the 4868 tooth surfaces examined, 9.2% were affected by fluorosis. In all cases, dental fluorosis was judged as mild, with most occurrences on the posterior teeth. No instances of moderate or severe fluorosis were found. The caries experience of respondents was 1.69 ± 2.73 DMFS. Caries experience does not appear to be significantly related to income, education, or fluoride supplement use. Approximately 52% of respondents were reported to have taken fluoride supplements with various degrees of consistency. Parents' education was positively related to both prevalence of fluorosis (odds ratio = 2.2) and use of fluoride supplements (odds ratio = 2.7). No significant relation was revealed with evidence of fluorosis and use of supplements. This study shows a relatively mild level of dental fluorosis in a sample of children from a non-fluoridated area. Dental fluorosis in this group does not appear to be related to use of fluoride supplements or differences in caries experience.
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Kadhum, Raghad I., and Alhan A. Qasim. "The impact of dental environment stress on caries experience, salivary flow rate and uric acid." Journal of Baghdad College of Dentistry 32, no. 1 (March 15, 2020): 35–41. http://dx.doi.org/10.26477/jbcd.v32i1.2756.

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Background: Several pathologies of the oral cavity have been associated with stress. Dental students need to gain assorted proficiencies as theoretical knowledge, clinical proficiencies, and interpersonal dexterity which is accompanied with high level of stress. Uric acid is the major antioxidant in saliva. The aim of this study is to assess the dental caries experience among dental students with different levels of dental environment stress in relation to physicochemical characteristics of whole unstimulated saliva. Materials and Methods: the total sample is composed of 300 dental students (73 males, 227 female) aged 22-23 years old, from collage of dentistry / university of Baghdad, from the 4th and 5th grade. The total sample was classified into three categories (mild stress, moderate stress and severe stress) according to Dental environment stress questionnaire (DESQ); Diagnosis and recording of dental caries were assessed according to Decay, Missed, Filled surface and teeth index (DMFS, DMFT) of WHO criteria in 1987. Unstimulated salivary samples were collected from the 95 dental students from the mild stress group (27 male, 28 female) and from the severe stress group (11 male, 29 female). Then, salivary flow rate was measured and chemically analyzed to determine salivary uric acid concentration. All data were analyzed using statistical package for social science (SPSS) version 21. Results: The mean value of the DMFT and DS fraction was higher among severe stress group of dental environment stress scale with no significant differences (P≥ 0.05), while DMFS, FS and MS fractions were higher among moderate stress group of dental environment stress scale with no significant differences (P≥ 0.05). The data from salivary analysis showed that the mean value of salivary flow rate was lower among severe dental environment stress category than mild dental environment stress category but the difference was statistically not significant, while the mean value of uric acid was higher among students with severe dental environment stress than students with mild dental environment stress with statistically significant difference. The flow rate was negatively correlated with caries experience among both mild and severe stress groups except for the DS was positively correlated with flow rate among students with mild stress. The correlation of uric acid with DMFT was negative among students with mild stress while among severe stress group was positive; however all these correlations were not statistically significant. Conclusion: Dental environment stress appears to affect oral health, shown by higher caries prevalence among dental students with moderate and severe dental environment stress level by affecting the normal level of salivary flow rate and uric acid. Keywords: Dental environment stress, stress, dental caries, flow rate, uric acid.
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Lawrence, Herenia P., James D. Beck, Ronald J. Hunt, and Gary G. Koch. "Adjustment of the M-component of the DMFS index for prevalence studies of older adults." Community Dentistry and Oral Epidemiology 24, no. 5 (October 1996): 322–31. http://dx.doi.org/10.1111/j.1600-0528.1996.tb00870.x.

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Surdacka, Anna, Krystyna Strzykała, and Anna Rydzewska. "Changeability of Oral Cavity Environment." European Journal of Dentistry 01, no. 01 (January 2007): 014–17. http://dx.doi.org/10.1055/s-0039-1698305.

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ABSTRACTObjectives: In dentistry, the results of in vivo studies on drugs, dental fillings or prostheses are routinely evaluated based on selected oral cavity environment parameters at specific time points. Such evaluation may be confounded by ongoing changes in the oral cavity environment induced by diet, drug use, stress and other factors. The study aimed to confirm oral cavity environment changeability.Methods: 24 healthy individuals aged 20–30 had their oral cavity environment prepared by having professional hygiene procedures performed and caries lesions filled. Baseline examination and the examination two years afterwards, evaluated clinical and laboratory parameters of oral cavity environment. Caries incidence was determined based on DMFT and DMFS values, oral cavity hygiene on Plaque Index (acc. Silness & Löe) and Hygiene Index (acc. O`Leary), and the gingival status on Gingival Index (acc. Löe & Silness) and Gingival Bleeding Index (acc. Ainamo & Bay). Saliva osmolarity, pH and concentrations of Ca2+, Pi, Na+, Cl-, total protein, albumins, F- and Sr2+ were determined.Results: The results confirmed ongoing changeability of the oral cavity environment. After 2 years of the study reduction in oral cavity hygiene parameters PLI and HI (P<0.1), and gingival indices as well as lower saliva concentration of Ca2+ (P<.001), Pi (P<.06), K+ (P<.04), Sr2+ (P<.03), Na+ (P<.1), against the baseline values, were observed. Total protein and albumin saliva concentrations were also significantly lower.Conclusion: Physiological oral cavity environment is subject to constant, individually different, changes which should be considered when analysing studies that employ oral cavity environment parameters. (Eur J Dent 2007;1:14-17)
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Al-Awadi, Dr Zahraa Ali, and Dr Baydaa Hussien Hussien. "Oral Health Status in Relation to Nutritional Status among 9 years old school Children in Dewanyiah City/Iraq." Mustansiria Dental Journal 14, no. 1 (January 4, 2019): 80. http://dx.doi.org/10.32828/mdj.v14i1.763.

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Background: Although they are not life threatening, dental caries and periodontaldisease are the most predominant and widely spread oral diseases throughout theworld. The aims of the study included the investigation of the prevalence andseverity of dental caries, gingivitis and dental plaque in relation to gender,furthermore, nutritional status was assessed in relation to oral health condition(dental caries).Materials and Methods: This oral health survey was conducted among primaryschool children aged 9 years old in Dewanyiah city in Iraq. The total samplecomposed of 600 child (320 males and 280 females) selected randomly fromdifferent school in Dewanyiah city. Diagnosis of dental caries was according tothe criteria described by WHO (1987). Plaque index of Silness and Loe (1964)was used for plaque assessment, gingival index of Loe and Silness (1963) wasfollowed for recording gingival health condition. Nutritional status was assessedaccording to body mass index (BMI) indicator using anthropometric measurement(height and weight).Results: Results showed that the prevalence of dental caries was 85% for 9 year-oldschool children. Regarding primary and permanent dentition, dental caries washigher among females compared to males with statistically significant difference(P<0.05) for primary dentition, on the other hand, males showed higher values offilled surfaces compared to females with statistically significant difference(P<0.05) for primary dentition and highly significant difference (P<0.01) forpermanent dentition. Finding of this study revealed that 100% of the children hadgingival inflammation. Furthermore, the values of plaque and gingival indiceswere higher among males compared to females with statistically highly significantdifferences (P<0.01). In current study, the prevalence of malnutrition described bythe BMI indicator was 5.3%. For total samples no significant difference wasrecorded in dmfs /DMFS values among wasting and well nourished children(P>0.05).Conclusion: A high prevalence of dental caries and gingivitis were recorded.Improvement in the prevention educational programs is needed among schoolchildren.
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Chitapanarux, Imjai, Wannapha Nobnop, Patumrat Sripan, Ausareeya Chumachote, Ekkasit Tharavichitkul, Somvilai Chakrabandhu, Pitchayaponne Klunklin, et al. "The outcome of the first 100 nasopharyngeal cancer patients in thailand treated by helical tomotherapy." Radiology and Oncology 51, no. 3 (April 21, 2017): 351–56. http://dx.doi.org/10.1515/raon-2017-0017.

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Abstract BackgroundThe aim of the study was to analyse of two-year loco-regional failure free survival (LRFFS), distant metastasis free survival (DMFS), overall survival (OS), and toxicity outcomes of the first 100 nasopharyngeal carcinoma patients in Thailand treated by helical tomotherapy. Patients and methods Between March 2012 and December 2015, 100 patients with non-metastatic nasopharyngeal carcinoma were treated by helical tomotherapy. All patients were treated by platinum-based concurrent chemoradiotherapy and adjuvant or neo-adjuvant chemotherapy. ResultsThe median age was 51 years (interquartile ranges [IQR]: 42.5–57.0). The mean ± SD of D95% of planning target volume (PTV) 70, 59.4 and 54 were 70.2 ± 0.5, 59.8 ± 0.6, and 54.3 ± 0.8 Gy, respectively. The mean ± SD of conformity index, and homogeneity index were 0.89 ± 0.13 and 0.06 ± 0.07. Mean ± SD of D2 % of spinal cord and brainstem were 34.1 ± 4.4 and 53.3 ±6.3 Gy. Mean ± SD of D50 of contralateral and ipsilateral parotid gland were 28.4 ± 6.7 and 38.5 ± 11.2 Gy. At a median follow-up of 33 months (IQR: 25–41), the 2-year LRFFS, DMFS, OS were 94% (95%CI: 87–98%), 96% (95% CI: 89–98%), and 99% (95% CI: 93–100%), respectively. Acute grade 3 dermatitis, pharyngoesophagitis, and mucositis occurred in 5%, 51%, and 37%, respectively. Late pharyngoesophagitis grade 0 and 1 were found in 98% and 2% of patients. Late xerostomia grade 0, 1 and 2 were found in 17%, 78% and 5%, respectively. ConclusionsHelical tomotherapy offers good dosimetric performance and achieves excellent treatment outcome in nasopharyngeal carcinoma patients.
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Tantradi, Praveena, V. Sreenivasan, and Harish Kadaganche. "Role of bitewing in enhancing the assessment of DMFS index in a group of Indian adolescents." Indian Journal of Dental Research 21, no. 2 (2010): 266. http://dx.doi.org/10.4103/0970-9290.66653.

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43

Frencken, J. E., W. H. Palenstein Helderman, and J. Mulder. "Correction factor for the M-component in DMFS-index in child and adolescent population in Tanzania." Community Dentistry and Oral Epidemiology 18, no. 3 (June 1990): 159–60. http://dx.doi.org/10.1111/j.1600-0528.1990.tb00043.x.

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44

Chang, Po-Sen, Chun-Jui Huang, Chia-Lan Hsiang, Hongmin Lai, and Aileen I. Tsai. "Prevalence of Dental Caries and Periodontal Disease of High School Students Aged 15 to 18 Years in Taiwan." International Journal of Environmental Research and Public Health 18, no. 19 (September 22, 2021): 9967. http://dx.doi.org/10.3390/ijerph18199967.

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The purpose of this study was to assess the prevalence and distribution of dental caries and periodontal disease in Taiwanese high school students aged 15–18. A total of 1069 Taiwanese students participated in a cross-sectional nationwide dental survey. By using a stratified method based on the National Health Insurance administration regions, 24 high schools were randomly sampled in different areas of Taiwan. The participants were examined with dental mirrors and community periodontal index (CPI) probes without using radiographs, to measure dental caries and periodontal status. Demographic information and other relevant risk indicators for the two diseases were gathered via a self-report questionnaire. In this study population, the weighted mean decayed, missing and filled teeth (DMFT) scores for ages 15 to 18 were 5.2, 6.1, 6.1, and 5.7. The weighted mean decayed, missing and filled surfaces (DMFS) scores were 9.0, 12.0, 13.1, and 11.2 at ages 15, 16, 17, and 18, respectively. Additionally, 88.2% of the subjects had periodontal disease, with calculus as the most prevalent type. Moreover, 5.2% of these students showed loss of attachment. There was no significant association between dental caries and periodontal disease. Dental caries and periodontal disease were prevalent among Taiwanese high school students in this national dental survey.
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Jameel, Sara A., and Nadia A. Al rawi. "Assessment of caries experience, enamel defects and selected salivary biomarkers in children with nutritional rickets." Journal of Baghdad College of Dentistry 31, no. 1 (March 15, 2019): 37–41. http://dx.doi.org/10.26477/jbcd.v31i1.2576.

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Background: Nutritional Rickets is a condition produced by an absence of Vitamin D, calcium or phosphate. It clues to relaxing and fading of the bones. Dental expression of children with rickets contains enamel hypoplasia and delayed tooth eruption. This study was conducted in order to assess caries experience (dmfs) and enamel defects among study and control groups, and to evaluate and compare the levels of selected salivary biomarkers between children with nutritional rickets and apparently healthy children. Material and methods: Assessment of caries according to WHO in 1987, and assessment of enamel defects according to enamel defect index EDI of WHO in 1997. In addition a stimulated saliva samples were collected according to Palone et al from 30 children diagnosed with nutritional rickets and 30 control children as control group. Salivary vitamin D, calcium, phosphate and alkaline phosphtase were analyzed. Results: Caries experience represented by dmfs was significantly higher among control group compared to study group, while enamel hypoplasia was higher in study group than control group. Salivary inorganic component (Ca, PO4 ALP) revealed obvious variations between study and control group. Salivary vitamin D concentration was lower in study group compared with control group. Conclusion: Based on the results, it can be concluded that nutritional rickets impact on certain salivary biomarkers which can be considered for evaluating the diagnosis and prognosis of caries experience and enamel defects in nutritional rickets children
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Poorterman, J. H. G., I. H. A. Aartman, J. A. Kieft, and H. Kalsbeek. "Value of Bite–Wing Radiographs in a Clinical Epidemiological Study and Their Effect on the DMFS Index." Caries Research 34, no. 2 (2000): 159–63. http://dx.doi.org/10.1159/000016584.

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47

Kingman, A., and R. H. Selwitz. "Proposed methods for improving the efficiency of the DMFS index in assessing initiation and progression of dental caries." Community Dentistry and Oral Epidemiology 25, no. 1 (February 1997): 60–68. http://dx.doi.org/10.1111/j.1600-0528.1997.tb00900.x.

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48

Munjal, Vaibhav, Puneet Singh Talwar, Jagjit Singh, Mandeep Kumar, and Ramandeep Gambhir. "Dental caries and its association with present day dietary patterns: a cross-sectional study." International Journal Of Community Medicine And Public Health 5, no. 5 (April 24, 2018): 2138. http://dx.doi.org/10.18203/2394-6040.ijcmph20181737.

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Background: Dental caries is a multifactorial disease with diet being one of the contributing factors. The influence of vegetarianism on the development of caries has scarcely been investigated in the past. Therefore, this study was done to evaluate the association of dental caries with frequency of sugar exposures and vegetarian / mixed diet.Methods: The present cross-sectional study was conducted among 2500 school children of 12 and 15 years age groups selected on the basis of simple random sampling from different schools of the city. Dental caries was recorded using Decayed, Missing and Filled teeth index (WHO modification, 1997) and correlated with the different dietary variables. Subjects were also segregated on the basis of diet: vegetarian and mixed. Statistical analysis was done using Student t-test and Pearson’s Correlation Coefficient.Results: The prevalence of dental caries in the 12 and 15 year age group of subjects consuming mixed diet was 83.36% and 86.47% respectively. It was lower in case of subjects on vegetarian diet. The correlation between DMFS and TSE, FSE and AMSE was found to be statistically significant (p<0.05) in the 12 year age-group. In the 15 year age-group the correlation of DMFS with TSE and LSE was also found to be statistically significant (p<0.05).Conclusions: There was no statistically significant difference in dental caries status among subjects in both the groups (vegetarian and mixed). However, there was significant association between sugar exposures and dental caries among subjects of both the age-groups.
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Hung, Ha Van, Vo Truong Nhu Ngoc, Hue Vu Thi, and Dinh-Toi Chu. "Early Childhood Caries in Obese Children: The Status and Associated Factors in the Suburban Areas in Hanoi, Vietnam." International Journal of Environmental Research and Public Health 18, no. 16 (August 22, 2021): 8844. http://dx.doi.org/10.3390/ijerph18168844.

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Obesity and early childhood caries are two prominent health problems affecting the majority of children worldwide. Thus, early childhood caries in obese children must be studied. This study was conducted to investigate the status of early childhood caries in obese children in Hanoi, Vietnam, and its associated factors. A cross-sectional study was conducted on 234 obese children, 234 normal children (non-obese) aged 36 to 71 months, and their mothers at some kindergartens in Hanoi. Study subjects were randomly selected with similarities in age, gender, and study location. Decayed tooth of children was detected by clinical examination and Diagnodent Kavo 2190 machine of Germany. In addition, a questionnaire for their mothers was used to find out related factors. We found that, in the Obese Group, the rate of early childhood caries (ECC), severe-early childhood caries (S-ECC), dmft index (the number of decayed teeth, teeth lost due to cavities, filled decayed teeth or filled cavity), and dmfs index (the number of surfaces of the teeth decay, surfaces of teeth were lost due to cavities, surfaces of filled decayed teeth) were 82.91%, 59.83%, 6.84 ± 4.92, and 9.10 ± 7.48, respectively. In the Normal Group, these rates were smaller than in the Obese Group, but the difference was not statistically significant. Regarding related factors, the hobby of drinking soft drinks, the habits and frequency of drinking milk at night and eating sweet marshmallows were associated with ECC in the Obese Group with p < 0.05. In conclusion, the higher rates of ECC were seen in obese children, with eating hobbies and habits being the related factors. Therefore, it is necessary to have appropriate policies and effective communication strategies to minimize ECC in the future.
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Kuppan, Anuradha, Steven Rodrigues, Victor Samuel, Mahesh Ramakrishnan, Hassan S. Halawany, Nimmi B. Abraham, Vimal Jacob, and Sukumaran Anil. "Prevalence and Heritability of Early Childhood Caries Among Monozygotic and Dizygotic Twins." Twin Research and Human Genetics 20, no. 1 (January 20, 2017): 43–52. http://dx.doi.org/10.1017/thg.2016.96.

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Deciphering the relative importance of genetic and environmental factors, which play a major role in the prevalence of early childhood caries (ECC), can help clinicians with planning a long-term preventive treatment. The objective of the study was to determine the prevalence and heritability of ECC among monozygotic (MZ) and dizygotic (DZ) twins in Chennai, India, in the year 2013. A cross-sectional study was designed to estimate the prevalence of ECC among twins. Zygosity classification for the survey framework was adapted from a highly accurate parental report questionnaire pertaining to the physical similarity between twins. The associated heritability index was estimated. The Decayed, Missing, Filled Surface (DMFS) Index was used as the diagnostic criterion for dental caries. The prevalence of ECC was estimated at 18.7%. The correlation coefficient between the twin pair showed significant correlation. The heritability index for ECC was estimated at 15% higher prevalence of ECC found among children in the age group 25–36 months. The heritability estimate indicated a relatively low genetic influence for early childhood caries among twins. There was no significant difference detected in the concordance rate for the MZ and DZ twins. Further research could be directed toward the prevalence of ECC among higher age group children to explore the role of genetic and environmental factors.
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