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Journal articles on the topic 'DMPT'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Buyuktas, Birsen S., та Philip P. Power. "Synthesis and characterization of the monomeric molybdenum trithiolate Mo(η7-dmpt)(η1-dmpt)2 (dmpt = 2,6-dimesitylphenylthiolate)". Chemical Communications, № 16 (1998): 1689–90. http://dx.doi.org/10.1039/a803064b.

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Lucena, Débora Dias de, Renato de Marco, João Roberto de Sá, José Osmar Medina-Pestana, Maria Gerbase-DeLima, and Érika Bevilaqua Rangel. "ANTíGENOS HLA ESTÃO ASSOCIADOS A RISCO DE DIABETES MELLITUS PÓS-TRANSPLANTE?" Brazilian Journal of Transplantation 24, no. 1 (2021): 6–14. http://dx.doi.org/10.53855/bjt.v24i1.2.

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Introdução: Diabetes mellitus pós-transplante (DMPT) tem impacto na morbidade e na mortalidade em receptores de transplante renal, uma vez que aumenta o risco de complicações cardiovasculares e de perda do enxerto renal. Os fatores de risco para DMPT podem ser divididos em modificáveis e não modificáveis. Ainda há controversas sobre a influência do sistema de antígenos leucocitários humanos (Human Leukocyte Antigens ou HLA) no risco de DMPT. Objetivo: Verificar prevalência para DMPT e sua relação com fatores genéticos. Métodos: Foram avaliados 450 pacientes submetidos ao transplante renal e re

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3

Bastos Jr., Marco A. V., Marcus M. S. Oliveira, Simone H. de Castro, et al. "Fatores de risco para o desenvolvimento de diabetes mellitus pós-transplante renal." Arquivos Brasileiros de Endocrinologia & Metabologia 49, no. 2 (2005): 271–77. http://dx.doi.org/10.1590/s0004-27302005000200014.

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Avaliamos retrospectivamente os prontuários de 34 pacientes com diabetes pós-transplante renal (DMPT) (grupo 1) e 68 transplantados sem DMPT (grupo 0) com objetivo de determinar a prevalência de fatores de risco conhecidos para desenvolvimento da doença em pacientes acompanhados no Hospital Universitário Pedro Ernesto. Observamos uma prevalência de DMPT de 7,4%. O grupo 1 apresentou maior idade no momento da coleta dos dados (p<0,005), maior idade no transplante (p<0,005), maior freqüência de doador cadáver de rim (p= 0,023) e de hipercolesterolemia (p=0,006) e menor freqüência de hipert

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Dunnick, June K., B. Alex Merrick, Amy Brix, et al. "Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure." Toxicologic Pathology 44, no. 6 (2016): 835–47. http://dx.doi.org/10.1177/0192623316637708.

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N, N-dimethyl-p-toluidine (DMPT; Cas No. 99-97-8), an accelerant for methyl methacrylate monomers in medical devices, is a nasal cavity carcinogen according to a 2-yr cancer study of male and female F344/N rats, with the nasal tumors arising from the transitional cell epithelium. In this study, we exposed male F344/N rats for 5 days to DMPT (0, 1, 6, 20, 60, or 120 mg/kg [oral gavage]) to explore the early changes in the nasal cavity after short-term exposure. Lesions occurred in the nasal cavity including hyperplasia of transitional cell epithelium (60 and 120 mg/kg). Nasal tissue was rapidly

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Pinheiro, Isabelly De Oliveira, Daniel Duarte Gadelha, Manuela Montenegro Dias de Carvalho, Paulo Cruz de Queiroz, Virginia Oliveira Fernandes, and Renan Magalhães Montenegro Junior. "Diabetes Mellitus Pós-transplante (DMPT)." Revista de Medicina da UFC 59, no. 1 (2019): 77. http://dx.doi.org/10.20513/2447-6595.2019v59n1p77-78.

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6

Bottino, Rita. "Simposio 1: Diabetes secundaria a diferentes tipos de trasplante." Revista de la Sociedad Argentina de Diabetes 54, no. 3Sup (2020): 10. http://dx.doi.org/10.47196/diab.v54i3sup.277.

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Simposio 1: Cuando la diabetes no es autoinmune Diabetes secundaria a diferentes tipos de trasplanteLa diabetes mellitus postrasplante (DMPT) es una complicación ampliamente informada que ocurre después del trasplante de órganos. La incidencia de DMPT se estima entre el 10-20% en los receptores de riñón y entre el 30-40% en los receptores de órganos sólidos, aunque se ha informado una variabilidad significativa (1). Se ha señalado de forma variable que se asocia con una mayor morbilidad y mortalidad.La incidencia de DMPT está afectada por factores de riesgo asociados directa e indirectamente a

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Acosta González, Juan Daniel, Lourdes Carolina Vázquez Jiménez, Tomás Rodríguez Yánez, Rodrigo Daza Arnedo, Stephanie Ospina Lopera, and Jorge Rico Fontalvo. "Opciones terapéuticas en pacientes con diabetes mellitus post trasplante (dmpt)." Anales de la Facultad de Ciencias Médicas (Asunción) 57, no. 2 (2024): 82–89. http://dx.doi.org/10.18004/anales/2024.057.02.82.

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La diabetes mellitus postrasplante (DMPT) es una complicación que se encuentra de forma frecuente y se sucede al trasplante de órganos. Existen factores predisponentes a esta complicación, son varios y pueden estar presentes en el pretrasplante, peritrasplante o ya en el pos trasplante; dentro de estos, se resaltan las terapias inmunosupresoras asociadas. La importancia clínica de DMPT radica en su impacto para la enfermedad cardiovascular (ECV) y enfermedad renal crónica (ERC). En el presente artículo hacemos una revisión de las intervenciones tradicionales y las nuevas terapias para el manej

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8

Zhang, Xiaoliang, Yangge Zhu, Zhiqiang Zhao, and Peilong Wang. "Study on the Reverse Flotation Separation of Smithsonite from Dolomite Using the Saponified 2-(4,4-Dimethylpentan-2-yl)-5,7,7-trimethyloctanoic Acid as a Collector." Minerals 13, no. 10 (2023): 1322. http://dx.doi.org/10.3390/min13101322.

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Dolomite, a prominent calcium-bearing gangue mineral found in carbonate-type zinc oxide ores, poses a significant challenge for effective flotation separation alongside smithsonite due to their highly similar surface properties. The present study explores the potential of 2-(4,4-dimethylpentan-2-yl)-5,7,7-trimethyloctanoic acid (2-DMPT) as a collector for the reverse flotation of smithsonite from dolomite. Micro-flotation experiments indicated that saponified 2-DMPT exhibited superior collecting ability and selectivity for dolomite over smithsonite under highly alkaline conditions. Specificall

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Denis, Aline B., Cristina A. Diagone, Ana M. G. Plepis, and Rommel B. Viana. "Kinetic Parameters during Bis-GMA and TEGDMA Monomer Polymerization by ATR-FTIR: The Influence of Photoinitiator and Light Curing Source." Journal of Spectroscopy 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/6524901.

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This study aimed to analyze the kinetic parameters of two monomers using attenuated total reflectance Fourier transform infrared (ATR-FTIR): 2,2-bis-[4-(2-hydroxy-3-methacryloxypropyl-1-oxy)-phenyl] propane (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA). The following were calculated to evaluate the kinetic parameters: maximum conversion rate (Rpmax), time at the maximum polymerization rate (tmax), conversion atRpmax, and total conversion recorded at the maximum conversion point after 300 s. Camphorquinone (CQ) and phenyl propanedione (PPD) were used in this study as photoinitiators,

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Xiong, Jin, Jinjie Chang, Jinxiong Cai, Ping Yin, and Siping Pang. "N-Functionalization of 5-Aminotetrazoles: Balancing Energetic Performance and Molecular Stability by Introducing ADNP." International Journal of Molecular Sciences 23, no. 24 (2022): 15841. http://dx.doi.org/10.3390/ijms232415841.

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5-aminotetrazole is one of the most marked high-nitrogen tetrazole compounds. However, the structural modification of 5-aminotetrazole with nitro groups often leads to dramatically decreased molecular stability, while the N-bridging functionalization does not efficiently improve the density and performance. In this paper, we report on a straightforward approach for improving the density of 5-aminotetrazole by introducing 4-amino-3,5-dinitropyrazole. The following experimental and calculated properties show that nitropyrazole functionalization competes well with energetic performance and mechan

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Sahu, Chandan, Deepanwita Ghosh, Kaushik Sen, and Abhijit K. Das. "Decomposition of O,S-dimethyl methylphosphonothiolate by ammonia on magnesium oxide: a theoretical study of catalytic detoxification of a chemical warfare agent." Physical Chemistry Chemical Physics 17, no. 31 (2015): 20231–49. http://dx.doi.org/10.1039/c5cp02442k.

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12

Crinson, M., and P. Nicholls. "Routes of electron transfer in beef heart cytochrome c oxidase: is there a unique pathway used by all reductants?" Biochemistry and Cell Biology 70, no. 5 (1992): 301–8. http://dx.doi.org/10.1139/o92-047.

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Cytochrome c oxidase oxidizes several hydrogen donors, including TMPD (N,N,N′,N′-tetramethyl-p-phenylenediamine) and DMPT (2-amino-6,7-dimethyl-5,6,7,8-tetrahydropterine), in the absence of the physiological substrate cytochrome c. Maximal enzyme turnovers with TMPD and DMPT alone are rather less than with cytochrome c, but much greater than previously reported if extrapolated to high reductant levels and (or) to 100% reduction of cytochrome a in the steady state. The presence of cytochrome c is, therefore, not necessary for substantial intramolecular electron transfer to occur in the oxidase.

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13

Vieira, Inês, Sofia Lopes, Carla Batista, et al. "DOES TIME TO DEVELOP POST- TRANSPLANTATION DIABETES PREDICT TIME TO GRAFT LOSS? AN ANALYSIS OF PATIENTS 20 YEARS POST-KIDNEY TRANSPLANT." Journal of the ASEAN Federation of Endocrine Societies 37, no. 2 (2022): 53. https://doi.org/10.15605/jafes.037.afes.84.

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INTRODUCTIONPost-transplantation diabetes (PTDM) is common after solid organ transplantation. There are data to suggest that this complication may influence the transplant outcomes, namely the risk of graft loss. To analyze whether there is a relationship between age at diagnosis and time to graft loss. METHODOLOGYRetrospective study with patients transplanted between 1989-2001 who developed PTDM. RESULTSWe included 41 patients who had transplantation 24.7 (± 2.4) years ago. Majority (68.3%) were males with a mean age at transplantation of 46.5 (± 11.3) years. The average (years) of diagnosis

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He, Yashu, Zhenyang Wang, Fengyu Wen, Igor S. Sirotin, Jianxin Mu, and Vyacheslav V. Kireev. "MMA-based fast-curing repair materials suitable for low-temperature application." Journal of Polymer Engineering 42, no. 4 (2022): 343–50. http://dx.doi.org/10.1515/polyeng-2021-0292.

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Abstract In this study, the application of methyl methacrylate (MMA) resin as the binder and standard sand as the aggregate has been employed to prepare the repair materials that can be cured in the sub-zero temperature environment. For this purpose, the redox initiation system of benzoyl peroxide (BPO) and N,N-dimethyl-p-toluidine (DMPT) has been used. Subsequently, the influence of initiator and accelerator content on the compressive strength, flexural strength, curing time and other properties of the materials has been revealed. At an ambient temperature of 0 °C, with BPO = 4.5% and DMPT =

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15

Soliman, Saied M., Ayman El-Faham, Assem Barakat, Alexandra M. Z. Slawin, John Derek Woollins, and Morsy A. M. Abu-Youssef. "Synthesis, X-ray Structure and Hirshfeld Surface Analysis of Zn(II) and Cd(II) Complexes with s-Triazine Hydrazone Ligand." Crystals 13, no. 8 (2023): 1232. http://dx.doi.org/10.3390/cryst13081232.

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The two group IIB complexes [Cd(DMPT)Cl2] (6) and [Zn(DMPT)Cl2] (7) of the tridentate ligand (DMPT), 2,4-bis(morpholin-4-yl)-6-[(E)-2-[1-(pyridin-2-yl) ethylidene]hydrazin-1-yl]-1,3,5-triazine were synthesized, and their structural aspects were elucidated with the aid of X-ray crystallography. Both complexes crystallized in the monoclinic crystal system, with P21/n as a space group. The unit cell parameters for 6 are a = 14.1563(9) Å, b = 9.4389(6) Å, c = 16.5381(11) Å and β = 91.589(5)° while the respective values for 7 are 11.3735(14), 13.8707(13), 14.9956(16), and 111.646(2)°. The unit cell

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Catalano, Francesco, Laura Nasello, and Daniel Guterding. "Quantum Computing Approach to Realistic ESG-Friendly Stock Portfolios." Risks 12, no. 4 (2024): 66. http://dx.doi.org/10.3390/risks12040066.

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Finding an optimal balance between risk and returns in investment portfolios is a central challenge in quantitative finance, often addressed through Markowitz portfolio theory (MPT). While traditional portfolio optimization is carried out in a continuous fashion, as if stocks could be bought in fractional increments, practical implementations often resort to approximations, as fractional stocks are typically not tradeable. While these approximations are effective for large investment budgets, they deteriorate as budgets decrease. To alleviate this issue, a discrete Markowitz portfolio theory (

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Henkel, Thomas, Günter Mayer, Jörg Hampl, et al. "From Microtiter Plates to Droplets—There and Back Again." Micromachines 13, no. 7 (2022): 1022. http://dx.doi.org/10.3390/mi13071022.

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Droplet-based microfluidic screening techniques can benefit from interfacing established microtiter plate-based screening and sample management workflows. Interfacing tools are required both for loading preconfigured microtiter-plate (MTP)-based sample collections into droplets and for dispensing the used droplets samples back into MTPs for subsequent storage or further processing. Here, we present a collection of Digital Microfluidic Pipetting Tips (DMPTs) with integrated facilities for droplet generation and manipulation together with a robotic system for its operation. This combination serv

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Schwartz, Dirk, Nicolas Grammel, Eva Heinzelmann, Ullrich Keller, and Wolfgang Wohlleben. "Phosphinothricin Tripeptide Synthetases in Streptomyces viridochromogenes Tü494." Antimicrobial Agents and Chemotherapy 49, no. 11 (2005): 4598–607. http://dx.doi.org/10.1128/aac.49.11.4598-4607.2005.

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ABSTRACT The tripeptide backbone of phosphinothricin (PT) tripeptide (PTT), a compound with herbicidal activity from Streptomyces viridochromogenes, is assembled by three stand-alone peptide synthetase modules. The enzyme PhsA (66 kDa) recruits the PT-precursor N-acetyl-demethylphosphinothricin (N-Ac-DMPT), whereas the two alanine residues of PTT are assembled by the enzymes PhsB and PhsC (129 and 119 kDa, respectively). During or after assembly, the N-Ac-DMPT residue in the peptide is converted to PT by methylation and deacetylation. Both phsB and phsC appear to be cotranscribed together with

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19

B., K. Rai. "Synthesis and physicochemical studies of nitrogen-oxygen and sulphur donor Schiff base complexes of cobalt(II), nickel(II) and copper(II)." Journal of Indian Chemical Society Vol. 90, Jan 2013 (2013): 105–8. https://doi.org/10.5281/zenodo.5764216.

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Department of Chemistry, L. N. T. College (B. R. A. Bihar University, Muzaffarpur), Muzaffarpur-842 002, Bihar, India <em>E-mail</em>: binodkr_rai@yahoo.co.in <em>Manuscript received 18 August 2009, revised 27 March 2012, accepted 11 April 2012</em> Hexacoordinated complexes of the general formula [M(DMPT)2X2], where M = cobalt(II), nickel(II) and copper(II); DMPT = 2,6-dimethyl-4-pyrone thiosemicarbazone (neutral bidentate Schiff base); X = Cl<sup>-</sup>, Br<sup>-</sup>, I<sup>-</sup>, NO<sub>3</sub><sup>- </sup>and ClO<sub>4</sub><sup>-</sup> have been synthesized. The complexes were charac

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Fathalla, Eman M., Morsy A. M. Abu-Youssef, Mona M. Sharaf, et al. "Synthesis, X-ray Structure of Two Hexa-Coordinated Ni(II) Complexes with s-Triazine Hydrazine Schiff Base Ligand." Inorganics 11, no. 5 (2023): 222. http://dx.doi.org/10.3390/inorganics11050222.

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The hydrazine s-triazine ligand (E)-4,4’-(6-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1,3,5-triazine-2,4-diyl)dimorpholine (DMPT) was used to synthesize two new Ni(II) complexes via a self-assembly technique. The two complexes were synthesized by a one-pot synthesis strategy and characterized by elemental analysis, FTIR and single-crystal X-ray diffraction analysis to be [Ni(DMPT)(H2O)3](NO3)2.3H2O (1) and [Ni(DMPT)(H2O)3](NO3)2.H2O (2). The structures of both complexes were very similar regarding the coordination sphere and counter anions, but differ only in the number of the crystal water m

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Padunglappisit, Chawal, Siwanath Posaya-anuwat, Varisara Sompoch, Poompat Piyawiwattanakoon, and Piyaphong Panpisut. "Effects of Different Amine Activators on the Monomer Conversion, Biaxial Flexural Strength, and Color Stability of Experimental Provisional Dental Restorations." European Journal of Dentistry 15, no. 03 (2021): 488–94. http://dx.doi.org/10.1055/s-0040-1721908.

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Abstract Objective The aim was to assess the effect of different amine activators including N, N-dimethyl-p-toluidine (DMPT) or Na-N-tolyglycine glycidyl methacrylate (NTGGMA) on chemical-activated monomer conversion, biaxial flexural strength (BFS), and color stability of composites for provisional dental restorations. Materials and Methods Two formulations of composites containing either DMPT (D-temp) or NTGGMA (N-temp) were prepared. The degree of monomer conversion was assessed. The BFS of the materials was tested using the ball-on-ring testing jig. The color difference (∆E00) of the mater

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Frings, Jannik, Tobias Dust, Jennifer Meyer, et al. "The Influence of Surgical Realignment Procedures on Dynamic Patellar Tracking: A Dynamic Magnetic Resonance Imaging-Controlled Feasibility Study." Diagnostics 12, no. 11 (2022): 2761. http://dx.doi.org/10.3390/diagnostics12112761.

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Persisting patellar maltracking following surgical realignment often remains unseen. The aim of this study was to analyze the effects of realignment procedures on patellofemoral kinematics in patients with patellofemoral instability (PFI) and patellofemoral maltracking (PM) by using dynamic magnetic resonance imaging (MRI). Patients planned for surgical patellar realignment due to PFI and a clinically and radiologically apparent PM between December 2019 and May 2022 were included. Patients without PM, limited range of motion, joint effusion, or concomitant injuries were excluded. Dynamic medio

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Fang, Tingting, Xiang Li, Jiting Wang, et al. "Effects of Three Compound Attractants in Plant Protein Diets on Growth, Immunity, and Intestinal Morphology of Yellow River Carp Cyprinus carpio var." Aquaculture Nutrition 2022 (May 13, 2022): 1–14. http://dx.doi.org/10.1155/2022/9510968.

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A feeding experiment was conducted to evaluate the effects of three compound attractants on the growth performance, immunity, and intestinal morphology of Yellow River (YR) carp. Five treatment groups were included in the feeding experiment. Group I consisted of a fishmeal-based diet (positive control), and group II was a plant protein diet (negative control). The compound attractants 1 ( 0.06 % dimethyl − beta − propiothetin DMPT + 0.22 % tangerine peel powder + 0.75 % yeast powder ), 2 ( 0.05 % garlic powder + 0.06 % DMPT + 0.75 % yeast powder ), and 3 ( 0.07 % sodium glutamate + 0.22 % tang

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Sumarno, Sumarno, Prida Novarita Trisanti, Bramantyo Airlangga, et al. "Setting Properties along Bone Cement Preparation and its Effect on Material Properties." Advanced Materials Research 1179 (January 31, 2024): 19–23. http://dx.doi.org/10.4028/p-mxmms2.

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Bone cement is a material used in many orthopedic surgeries. Polymethyl Methacrylate (PMMA) is one of the acrylic-based bone cement materials. PMMA will be mixed with an activator (N, N-Dimethyl-p-toluidine (DMPT)), initiator (Benzoyl Peroxide (BPO)), radiopacifier / filler (BaSO4), and Methyl Methacrylate monomer. Once the materials were mixed, the activator react with the initiator to form radicals and activate the bulk polymerization reaction between the MMA monomer and PMMA molecules. The bulk polymerization reaction occurs exothermically and increases the bulk temperature. Barium sulfate

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Siest, Gérard. "From DMDI “Drug Metabolism and Drug Interactions” to DMPT “Drug Metabolism and Personalized Therapy”." Drug Metabolism and Personalized Therapy 30, no. 1 (2015): 1. http://dx.doi.org/10.1515/dmdi-2015-0039.

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Prieto Álvarez, Leticia. "Neurologic Music Therapy with a Habilitative Approach for Older Adults with Dementia: A Feasibility Study." Music Therapy Perspectives 40, no. 1 (2022): 76–83. http://dx.doi.org/10.1093/mtp/miab021.

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Abstract The incidence of dementia continues to increase in our aging population. Numerous cognitive, behavioral, and psychological symptoms accompany this diagnosis, and the need for non-pharmacological interventions that may alleviate them is of paramount importance. This feasibility study presents the results of a crossover randomized control trial that evaluated the effects of neurologic music therapy with a habilitative approach on the treatment acceptability, cognition, mood, and behavior of older adults with moderate to severe dementia. Twenty-nine residents living in an assisted living

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Chadeayne, Andrew R., Duyen N. K. Pham, James A. Golen, and David R. Manke. "Quaternary tryptammonium salts: N,N-dimethyl-N-n-propyltryptammonium (DMPT) iodide and N-allyl-N,N-dimethyltryptammonium (DMALT) iodide." Acta Crystallographica Section E Crystallographic Communications 76, no. 8 (2020): 1357–60. http://dx.doi.org/10.1107/s2056989020010014.

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The solid-state structures of two quaternary trytpammonium salts, namely, N,N-dimethyl-N-n-propyltryptammonium (DMPT) iodide [systematic name: 2-(1H-indol-3-yl)-N,N-dimethyl-N-propylazanium iodide], C15H23N2 +·I−, and N-allyl-N,N-dimethyltryptammonium (DMALT) iodide, [systematic name: 2-(1H-indol-3-yl)-N,N-dimethyl-N-(prop-2-en-1-yl)azanium iodide], C15H21N2 +·I−, are reported. Both salts possess a trialkyltryptammonium cation and an iodide anion in the asymmetric unit, which are joined together through N—H...I interactions. The DMALT structure was refined as an inversion twin, and the allyl g

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Ulber de Baluatti, Valentina, Carlos Orué, Ariel Herrera, María Teresa Gait, Elena Hilas, and Lila Cornejo. "Reconocimiento de Salud y registro de enfermedad en la promoción de la salud bucal." Revista de la Facultad de Ciencias Médicas de Córdoba 61, no. 2 (2004): 33–39. http://dx.doi.org/10.31053/1853.0605.v61.n2.33143.

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Background: At present, epidemiologic dentistry has nunterous indexes to measure illness such as DMPT, dnift ami S-OHI which are broadty used for illnessdiagnosis in clilferent population groups. Qn the other hand, the mdcx INSAO proposed cliffers from the approach focused on the disease itself. INSAO offers a paranieter to measure the degree of health of teeth and gums and thus provides the patient with the infornation about their health. Objetive: The aún of this study is to analyze the usefulness of the information provided by the traditional indexes and those recorded by INSAO, to the oral

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Crean, Colin D., Genglin Zhang, Karen E. Pollok, et al. "Dimethylaminoparthenolide (DMAPT) in Multiple Myeloma." Blood 112, no. 11 (2008): 3672. http://dx.doi.org/10.1182/blood.v112.11.3672.3672.

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Abstract Background: The nuclear factor kappa B (NFkB) signaling pathway is constitutively activated and central to the pathogenesis of multiple myeloma (MM). We previously published the antitumor activity of the NFkB inhibitor parthenolide in MM. Dimethylaminoparthenolide (DMAPT) is a water-soluble analog of parthenolide. The improved bioavailability of DMAPT makes its appealing for clinical development. Objectives: To validate the effects of DMAPT both in vitro and in vivo MM models and to develop a rational strategy for a combination of DMAPT with other anti-MM agents. Methods: The in vitro

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Hideharu, Shintani. "Body Fluid Extraction of Toxic Dental Materials Made From Methyl Methacrylate And HPLC Analysis Combined With Automated SPE." International Journal of Clinical Pharmacology & Toxicology 3, no. 4 (2014): 128–35. https://doi.org/10.19070/2167-910X-1400024.

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Methyl methacrylate polymer (PolyMMA) is widely used as the composite resin for the dental plate. During the preparation process of PolyMMA by the polymerization reaction, benzoylperoxide (BPO) and N,N’-dimethyl p-toluidine (DMPT) are added as the initiator and the stimulator, respectively. These compounds exhibit toxicity as well as a residue potential, their use raises concerns regarding human safety. The degree of elution into serum or saliva was determined to evaluate risk to the user. Analysis was done by HPLC combined with solid-phase extraction using a C-18 col

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Fernandez, David I., Marc-Antoine Sani, and Frances Separovic. "Interactions of the Antimicrobial Peptide Maculatin 1.1 and Analogues with Phospholipid Bilayers." Australian Journal of Chemistry 64, no. 6 (2011): 798. http://dx.doi.org/10.1071/ch11062.

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The interactions of the antimicrobial peptide, maculatin 1.1 (GLFGVLAKVAAHVVPAIAEHF-NH2) and two analogues, with model phospholipid membranes have been studied using solid-state NMR and circular dichroism spectroscopy. Maculatin 1.1 and the P15G and P15A analogues displayed minimal secondary structure in water, but with zwitterionic dimyristoylphosphatidylcholine (DMPC) vesicles displayed a significant increase in α-helical content. In mixed phospholipid vesicles of DMPC and anionic dimyristoylphosphatidylglycerol (DMPG), each peptide was highly structured with ~80% α-helical content. In DMPC

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Suwalsky, M., L. Gimenez, V. Saenger, and F. Neira. "X-Ray Studies on Phospholipid Bilayers. VIII. Interactions with Chlorpromazine · HCl." Zeitschrift für Naturforschung C 43, no. 9-10 (1988): 742–48. http://dx.doi.org/10.1515/znc-1988-9-1018.

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Abstract Chlorpromazine is a widely used phenothiazine tranquilizer known to alter the shape of normal erythrocytes and their osmotic fragility. In order to understand the nature of the interactions chlorpromazine · HCl (CPZ · HCl) was made to interact with phospholipid bilayers formed by dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC). This study was carried out by X-ray diffraction on crystalline powders of various molar mixtures of CPZ · HCl with DMPE and DMPC, with and without water. It was found that CPZ · HCl significatively affects the bilayer struct

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Diebold, A., N. Kyritsakas, J. Fischer, and R. Weiss. "A Bis(6-methyl-2-pyridylmethyl) Thioether (DMPT) Copper(II) Complex, [Cu(OSO2CF3)2(C14H16N2S)].CH2Cl2." Acta Crystallographica Section C Crystal Structure Communications 52, no. 3 (1996): 632–34. http://dx.doi.org/10.1107/s0108270195012649.

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Bessonov, Kyrylo, and George Harauz. "Molecular dynamics investigation of myelin basic protein stability on lipid membranes." SURG Journal 4, no. 1 (2010): 79–86. http://dx.doi.org/10.21083/surg.v4i1.1102.

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Simulation of proteins and membranes composed of synthetic lipids on computer clusters provides molecular information that complements experimental data. This paper describes molecular dynamics (MD) approaches to study the properties of biological membranes and proteins using the freely available GROMACS package on the C-terminal α-helical peptide of myelin basic protein (MBP). We simulated a mixed membrane – consisting of 2-dimyristoyl-sn-glycero-3-phosphocholine/1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPC/DMPE), and a pure DMPC membrane, composed of 188 and 248 lipids, respectivel

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Gambassi, Bruno Bavaresco, André Filipe Lopes de Siqueira, Jozimar Prazeres, et al. "Dynamic Muscle Power Training With Elastic Bands Improve Lower Extremity Function and Balance in Older Chronic Stroke Survivors?" Topics in Geriatric Rehabilitation 41, no. 1 (2025): 3–9. https://doi.org/10.1097/tgr.0000000000000443.

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The present study aims to accomplish 2 primary objectives: (1) to confirm the presence of physical function impairment among older individuals who are survivors of chronic stroke and (2) to investigate the effects of a 12-week regimen of dynamic muscle power training (DMPT) utilizing elastic bands on the physical function of lower limbs (PFLL) and dynamic balance (DB) within this population. The research sample encompassed 2 distinct groups: healthy older adults (HOAG; n = 13) and older chronic stroke survivors (OCSSG; n = 8). An evident divergence in physical function was discernible between

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Selvarajan, Sandhiya, Akila Srinivasan, Deepanjali Surendran, Jayanthi Mathaiyan, and Sadishkumar Kamalanathan. "Association of genetic polymorphisms in vitamin D receptor (ApaI, TaqI and FokI) with vitamin D and glycemic status in type 2 diabetes patients from Southern India." Drug Metabolism and Personalized Therapy 36, no. 3 (2021): 183–87. http://dx.doi.org/10.1515/dmpt-2020-0178.

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Abstract Objectives To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Methods In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India. Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA1c) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polym

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Ahmad, Izhar, Mohd Nayab, and Tanzeel Ahmad. "Effect of gliding cupping with Roghan-e-Surkh in low back ache (Waja-uz-Zahr): a case series study." Drug Metabolism and Personalized Therapy 36, no. 3 (2021): 247–50. http://dx.doi.org/10.1515/dmpt-2020-0177.

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Abstract Objectives Pain in joints is a major clinical problem since ancient times. Waja-uz-Zahr stands for low back pain which may arise from internal or external structures of lumbosacral region due to Su-e-Mizaj sada or maddi due to the surplus of Burudat or accumulation of Kham Balgham in lower back. Imala (diversion) and Taqiya-e-Mavad (Evacuation) are inevitable in case of maddi amraz. Hijama (cupping therapy) is a simple, safe, tolerable, and effective regimenal modality, helpful in the treatment of aches and pains. Gruner mentioned a special kind of cupping method in the canon of medic

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Kostyshyn, Nazar M., Mechyslav R. Gzhegotskyi, Liybov P. Kostyshyn, and Stepan I. Mudry. "Effect of zoledronic acid on bone nanocomposites organization and prevention of bone mineral density loss in ovariectomized rats." Drug Metabolism and Personalized Therapy 36, no. 3 (2021): 239–45. http://dx.doi.org/10.1515/dmpt-2020-0187.

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Abstract Objectives Osteoporosis often occurs in individuals of different age groups, frequently during menopause and after ovariectomy. It increases the risk of pathological fractures almost twice. The aim of our research was to assess bone metabolism, nanocomposite structure of the tibia under conditions of ovariectomy and zoledronic acid treatment. Methods X-ray diffraction has been performed for nanostructure analysis of mineral crystallites and crystal lattice of hydroxyapatite in the tibia samples of ovariectomized rats with additional application of bisphosphonate zoledronic acid (0.025

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Collins, Joseph M., and Danxin Wang. "Co-expression of drug metabolizing cytochrome P450 enzymes and estrogen receptor alpha (ESR1) in human liver: racial differences and the regulatory role of ESR1." Drug Metabolism and Personalized Therapy 36, no. 3 (2021): 205–14. http://dx.doi.org/10.1515/dmpt-2020-0160.

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Abstract Objectives The function and expression of cytochrome P450 (CYP) drug metabolizing enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The expression of these enzymes is known to be controlled by many transcription factors (TFs), including ligand-free estrogen receptor alpha (ESR1, in the absence of estrogen). However, the relationship between the expression of ESR1, other TFs, and CYP enzymes in human liver is still unclear. Methods Using real-time PCR, we quantified the mRNA levels of 12 CYP enzymes and nine TFs in 246 human liver samples from Europ

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Olubodun-Obadun, Taiwo G., Ismail O. Ishola, and Olufunmilayo O. Adeyemi. "Potentials of autophagy enhancing natural products in the treatment of Parkinson disease." Drug Metabolism and Personalized Therapy 37, no. 2 (2021): 99–110. http://dx.doi.org/10.1515/dmpt-2021-0128.

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Abstract Parkinson disease (PD) is a progressive neurodegenerative movement disorder characterized by motor and non-motor symptoms due to loss of striatal dopaminergic neurons and disruption of degradation signaling leading to the formation of Lewy bodies (aggregation of α-synuclein). Presently, there are no disease modifying therapy for PD despite improvement in the understanding of the disease pathogenesis. However, the drugs currently used in PD management provide symptomatic relieve for motor symptoms without significant improvement in non-motor complications, thus, a public health burden

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Ansari, Shabnam, Mohammad Maaz, Iftekhar Ahmad, et al. "Quality control, HPTLC analysis, antioxidant and antimicrobial activity of hydroalcoholic extract of roots of qust (Saussurea lappa, C.B Clarke)." Drug Metabolism and Drug Interactions 36, no. 2 (2020): 145–53. http://dx.doi.org/10.1515/dmpt-2020-0159.

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Abstract Objectives Saussurea lappa, CB Clarke (S.lappa) is a perennial herb of the Compositae family. The root of S.lappa has been used for the treatment of various diseases such as hepatitis, jaundice, intestinal worms, bronchial asthma, and a variety of skin diseases. The aim of the study was to ensure quality control of S.lappa and its preparation HAESL (hydroalcoholic extract of S.lappa) along with assessment of HAESL antimicrobial and antioxidant activities in vitro. Methods HAESL was prepared with 50% ethanol, (v/v). Physiochemical analysis of the root of S.lappa, and phytochemical scre

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Taher, Muhammad, Noratika Tik, and Deny Susanti. "Drugs intervention study in COVID-19 management." Drug Metabolism and Drug Interactions 36, no. 2 (2021): 87–98. http://dx.doi.org/10.1515/dmpt-2020-0173.

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Abstract By 9 February 2021, the Coronavirus has killed 2,336,650 people worldwide and it has been predicted that this number continues to increase in year 2021. The study aimed to identify therapeutic approaches and drugs that can potentially be used as interventions in Coronavirus 2019 (COVID-19) management. A systematic scoping review was conducted. Articles reporting clinical evidence of therapeutic management of COVID-19 were selected from three different research databases (Google Scholar, PubMed, and Science Direct). From the database search, 31 articles were selected based on the study

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Ishola, Ismail O., Folashade O. Katola, and Olufunmilayo O. Adeyemi. "Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of Curcuma longa: its interaction with anxiolytic-hypnotics." Drug Metabolism and Drug Interactions 36, no. 2 (2020): 135–43. http://dx.doi.org/10.1515/dmpt-2020-0147.

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Abstract Objectives Concurrent use of herbs with drugs have become a major healthcare problem. Herb-drug interactions could lead to therapeutic failure or toxicity. Hence, this study seeks to evaluate the impact of combining Curcuma longa rhizome (CL) with selected anxiolytic and hypnotic drugs. Methods CL (100, 200 or 400 mg/kg, p.o.) was administered to mice 1 h before subjecting the animals to elevated plus maze (EPM), hole board test (HBT), open field test (OFT) and rotarod test for anxiolytic-like effect as well as hexobarbitone-induced sleeping time (HIST) for hypnotic activity. The invo

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Tomek, Aleš, Tereza Šrámková, Vojtěch Kaplan, et al. "Pharmacogenetic algorithm for predicting daily dose of warfarin in Caucasian patients of Czech origin." Drug Metabolism and Drug Interactions 36, no. 2 (2020): 123–28. http://dx.doi.org/10.1515/dmpt-2020-0171.

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Abstract Objectives Warfarin use is limited by a low therapeutic index and significant interindividual variability of the daily dose. The most important factor predicting daily warfarin dose is individual genotype, polymorphisms of genes CYP2C9 (warfarin metabolism) and VKORC1 (sensitivity for warfarin). Algorithms using clinical and genetic variables could predict the daily dose before the initiation of therapy. The aim of this study was to develop and validate an algorithm for the prediction of warfarin daily dose in Czech patients. Methods Detailed clinical data of patients with known and s

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Fatima, Sana, Nafis Haider, Md Anzar Alam, Mohd Abdul Gani, Rafeeque Ahmad, and Murtada Taha. "Herbal approach for the management of C0VID-19: an overview." Drug Metabolism and Drug Interactions 36, no. 1 (2020): 1–8. http://dx.doi.org/10.1515/dmpt-2020-0150.

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Abstract COVID-19 is the most recently discovered coronavirus infectious disease and leads to pandemic all over the world. The clinical continuum of COVID-19 varies from mild illness with non-specific signs and symptoms of acute respiratory disease to extreme respiratory pneumonia and septic shock. It can transmit from animal to human in the form of touch, through the air, water, utensils, fomite and feco-oral route blood. The pathogenesis and clinical features of COVID-19 be the same as the clinical manifestation associated epidemic Fever. In Unani medicine, various herbal drugs are described

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Ragia, Georgia, Evgenia Katsika, Charalampia Ioannou, and Vangelis G. Manolopoulos. "TCF7L2 rs7903146 C>T gene polymorphism is not associated with hypoglycemia in sulfonylurea-treated type 2 diabetic patients." Drug Metabolism and Drug Interactions 36, no. 2 (2020): 165–68. http://dx.doi.org/10.1515/dmpt-2020-0168.

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Abstract Objectives Hypoglycemia is the most common adverse effect of sulfonylureas (SUs) and a major concern when using these drugs. Transcription factor 7-like 2 (TCF7L2) rs7903146 C>T polymorphism is an established and well characterized genetic marker of type 2 diabetes (T2DM) risk. The aim of the present study was to analyze the potential association of TCF7L2 rs7903146 C>T polymorphism with SU-induced hypoglycemia in a well characterized cohort of SU-treated patients previously genotyped for cytochrome P450 2C9 (CYP2C9) and P450 oxidoreductase (POR). Methods The study group consist

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Salem Hareedy, Mohammad, Sonya Mohamed Rashad, Helal F. Hetta, Sara Mahmoud Hassanien, Hebatallah Abdellatif, and Manal Hassanien. "CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine." Drug Metabolism and Drug Interactions 36, no. 2 (2021): 99–111. http://dx.doi.org/10.1515/dmpt-2020-0164.

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Abstract Objectives Hydroxychloroquine (HCQ) has been used as an off label for the management of coronavirus disease (Covid-19) infection with other drugs. However, different genetic variants can affect the metabolism of HCQ leading to inter-individual differences in its efficacy. In this study, we investigated the effects of variants in CYP2D6, CYP3A4 and CYP3A5 on the risk of Covid-19 infection among patients receiving HCQ for controlling rheumatoid arthritis (RA). Methods A total of 60 patients were genotyped for CYP2D6*2XN, CYP2D6*4, CYP3A4*1B and CYP3A5*2. They were receiving HCQ for the

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Aremu, Peter A., Abayomi M. Ajayi, Benneth Ben-Azu, Olayinka T. Orewole, and Solomon Umukoro. "Spinal and general anesthesia produces differential effects on oxidative stress and inflammatory cytokines in orthopedic patients." Drug Metabolism and Drug Interactions 36, no. 1 (2020): 17–23. http://dx.doi.org/10.1515/dmpt-2020-0134.

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Abstract Objectives The contribution of anesthetic procedure to surgical stress and postoperative complications has been attributed to increased oxidative stress and release of inflammatory cytokines. Thus, the levels of oxidative stress biomarkers and inflammatory cytokines in patients with general anesthesia (GA) and spinal anesthesia (SA) that underwent open reduction and internal fixation (ORIF) in orthopedic surgery at Federal Teaching Hospital, Ido-Ekiti, Ekiti state, Nigeria were investigated. Methods Forty patients were randomly distributed into two groups (n = 20) namely GA and SA. Bl

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Atuadu, Vivian, Ben-Azu Benneth, John Oyem, et al. "Adansonia digitata L. leaf extract attenuates lead-induced cortical histoarchitectural changes and oxidative stress in the prefrontal cortex of adult male Wistar rats." Drug Metabolism and Drug Interactions 36, no. 1 (2020): 63–71. http://dx.doi.org/10.1515/dmpt-2020-0116.

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Abstract Objectives Adansonia digitata L. is popularly known for the management of various neurological diseases in ethno-medicine. Studies have shown that lead toxicity is a possible risk factor for early onset of neurodegenerative disease. Hence, this study was designed to evaluate the effect of A. digitata aqueous leaf extract (ADALE) against lead-induced oxidative stress and histo-architectural changes in the prefrontal cortex of adult Wistar rats. Methods Saline (10 mL/kg), ADALE (500 and 1000 mg/kg) and EDTA (55 mg/kg) were pretreated orally 30 min prior to lead acetate (LA) (120 mg/kg)

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Ahmad, Izhar, Tanzeel Ahmad, and Mohd Aleemuddin Quamri. "Clinical efficacy of Majoon Falasfa and Roghan-e-Surkh in post-stroke-disability: an open labeled, pre-post analysis." Drug Metabolism and Drug Interactions 36, no. 1 (2020): 41–46. http://dx.doi.org/10.1515/dmpt-2020-0144.

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Abstract Objectives Stroke is one of the leading causes of death and disability in India. The estimated adjusted prevalence rate of stroke range, 84–262/100,000 in rural and 334–424/100,000 in urban areas. A deficit in motor function affects mobility, daily activity of life. Rehabilitation is the most useful method to reduce deficit motor function. Hemiplegia (Falij), is one of the most common disability resulting from stroke has been described by Unani physicians, and they treat the disease effectively on the principle of Tanqia (evacuation) and Tadeel (alterative). Hence, a study contemplate

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