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Relevant bibliographies by topics / DNA aptamers

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Dissertations / Theses

Academic literature on the topic 'DNA aptamers'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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Dissertations / Theses on the topic "DNA aptamers"

1

Mejri, Nawel. "Development of biosensors based on DNA aptamers for direct mycotoxins detection." Thesis, Perpignan, 2016. http://www.theses.fr/2016PERP0010.

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Le travail réalisé au cours de cette thèse a porté sur le développement de biocapteurs électrochimiques d’affinité, sensibles et sélectifs, pour la détection de l’ochratoxine A (OTA) et l’aflatoxine M1 (AFM1). Les biocapteurs développés reposent sur l’association de différents nanomatériaux pour une meilleure performance analytique. Pour construire notre transducteur, nous avons associé le polypyrrole à des dendrimères poly(amido-amine) PAMAM, ce qui a permis d’avoir de très bon rendements grâce au propriétés électriques du polypyrrole et à l’augmentation de la surface active due à la structur

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2

Marquardt, Janice Dionne. "Force interaction characterization between thrombin and DNA aptamers." [Ames, Iowa : Iowa State University], 2008.

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3

Bayrac, Abdullah Tahir. "In Vitro Selection Of Dna Aptamers To Glioblastoma Multiforme." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613769/index.pdf.

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Aptamer probes for specific recognition of glioblastoma multiforme were generated using a repetitive and broad cell-SELEX-based procedure without negative selection. The 454 sequencing technology was used to monitor SELEX, and bioinformatics tools were used to identify aptamers from high throughput data. A group of aptamers were generated that can bind to target cells specifically with dissociation constants (K d ) in the nanomolar range. Selected aptamers showed high affinity to different types of glioblastoma cell lines, while showing little or

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4

Kärkkäinen, Riikka M. "Production of DNA aptamers with specificity for bacterial food pathogens." Thesis, University of Chester, 2012. http://hdl.handle.net/10034/620695.

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Aptamers are biomolecular ligands composed of nucleic acids. They can be selected to bind specifically to a range of target molecules and subsequently exploited in a fashion analogous to more traditional biomolecules such as antibodies. In this study a method for selecting new aptamers which specifically bind whole live bacterial cells is described. A non-pathogenic strain of Escherichia coli K12 was used to develop the method. A DNA library containing 100 bases long random nucleotide sequences was produced and the aptamer selection process was repeated nine times. An enzyme-linked technique w

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5

Joseph, Diego F., Jose A. Nakamoto, Ruiz Oscar Andree Garcia, et al. "DNA aptamers for the recognition of HMGB1 from Plasmodium falciparum." Public Library of Science, 2019. http://hdl.handle.net/10757/655484.

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Rapid Diagnostic Tests (RDTs) for malaria are restricted to a few biomarkers and antibody-mediated detection. However, the expression of commonly used biomarkers varies geographically and the sensibility of immunodetection can be affected by batch-to-batch differences or limited thermal stability. In this study we aimed to overcome these limitations by identifying a potential biomarker and by developing molecular sensors based on aptamer technology. Using gene expression databases, ribosome profiling analysis, and structural modeling, we find that the High Mobility Group Box 1 protein (HMGB1)

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6

Lu, Chenze. "Nano-assemblages d'ADN induites par des cibles - Détection de petites cibles par formation de réseaux d'ADN." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV066/document.

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La détection de petites molécules contribue au développement de nombreux domaines tels que la sécurité alimentaire, la sécurité intérieure, le diagnostic, le contrôle de l'environnement, etc. Cependant, la petite taille de ces cibles et leur faible concentration rendent difficile leur détection. Pour pallier à cela, des biocapteurs avec des sondes appropriées et des stratégies d'amplification du signal sont nécessaires. Parmi les éléments de reconnaissance couramment utilisés, les aptamères présentent l'avantage d'une synthèse aisée et de grandes possibilités de modification, ainsi qu'une déna

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7

Chumphukam, Orada. "Proximity dependent ligation selection : a new approach to generating DNA aptamers." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24836.

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Nucleic acid aptamers are a group of molecules which emerge from large random sequence pools through in vitro selection, a process called Systematic Evolution of Ligands by EXponential enrichment (SELEX). These recognition molecules are a potential alternative to antibodies and offer a greater thermal stability, robustness and chemical versatility. The first part of this thesis describes the selection of an aptamer against acetylcholinesterase (AChE) using conventional in vitro selection process. The pool enrichment was observed during 15 rounds of selection and a chosen aptamer, R15/19, was c

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8

Lin, Ying [Verfasser]. "Isolation and characterization of DNA aptamers for zinc finger proteins / Ying Lin." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023581051/34.

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9

Bunka, David Harry John. "Isolation and characterisation of RNA aptamers against DNA binding domains and amyloid." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275670.

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10

Shahidi, Hamedani Nasim [Verfasser]. "Functional Modulation of Activated Protein C using DNA-Aptamers / Nasim Shahidi Hamedani." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1130704696/34.

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