Relevant bibliographies by topics / DNA bis-intercalating agents

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Academic literature on the topic 'DNA bis-intercalating agents'

Author: Grafiati
Published: 19 February 2023

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Journal articles on the topic "DNA bis-intercalating agents"

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Moloney, Gerard, David Kelly, and P. Mack. "Synthesis of Acridine-based DNA Bis-intercalating Agents." Molecules 6, no. 3 (February 28, 2001): 230–43. http://dx.doi.org/10.3390/60300230.

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Párkányi, Cyril, Hui Liang Yuan, and Meng-Kan Michael Tsai. "Potential DNA bis-intercalating agents. Bridged bis-(6-chloropurines) and related compounds." Journal of Heterocyclic Chemistry 28, no. 2 (February 1991): 465–67. http://dx.doi.org/10.1002/jhet.5570280249.

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Plsikova, Jana, Ladislav Janovec, Jan Koval, Jan Ungvarsky, Jaromir Mikes, Rastislav Jendzelovsky, Peter Fedorocko, et al. "3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents." European Journal of Medicinal Chemistry 57 (November 2012): 283–95. http://dx.doi.org/10.1016/j.ejmech.2012.09.020.

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PARKANYI, C., H. L. YUAN, and M. K. M. TSAI. "ChemInform Abstract: Potential DNA Bis-Intercalating Agents. Bridged Bis-(6-chloropurines) and Related Compounds." ChemInform 22, no. 30 (August 23, 2010): no. http://dx.doi.org/10.1002/chin.199130219.

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Jaycox, Gary D., Gordon W. Gribble, and Miles P. Hacker. "Potential DNA bis-intercalating agents: Synthesis and antitumor activity of novel, conformationally restricted bis(9-aminoacridines)." Journal of Heterocyclic Chemistry 24, no. 5 (September 1987): 1405–8. http://dx.doi.org/10.1002/jhet.5570240535.

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W. Gribble, Gordon, Michael D. Mosher, Gary D. Jaycox, Michael Cory, and Terri A. Fairley. "Potential DNA Bis-Intercalating Agents. Synthesis and Antitumor Activity of N,N'-(Methylenedi-4,1-cyclohexanediyl-bis(9-acridinamine) Isomers." HETEROCYCLES 88, no. 1 (2014): 535. http://dx.doi.org/10.3987/com-13-s(s)77.

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Párkányi, Cyril, Hui Liang Yuan, Martha C. Marín-Montes, and Hans T. Essoussi. "Synthesis of polymethylene chain-bridged 6-substituted 8-azapurines and related compounds." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2382–88. http://dx.doi.org/10.1135/cccc19912382.

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The synthesis of a series of polymethylene chain-bridged 8-azapurines as potential DNA intercalating agents is described. N,N’-Bis(5-amino-6-chloro-4-pyrimidyl)-1,3-diaminopropane (III), N,N”-bis(5-amino-6chloro-4-pyrimidyl)-1,8-diaminooctane (IV), and N,N’-bis(5-amino-6-chloro-4-pyrimidyl)-1,12-diaminododecane (V) were synthesized from 5-amino-4,6-dichloropyrimidine (I) and 1,3-diaminopropane (II, n = 3), 1,8-diaminooctane (II, n = 8), and 1,12-diaminododecane (II, n = 12), respectively, as the starting materials. 1,3-Bis(6-chloro-9-purinyl)propane (VI), 1,8-bis(6-chloro-9-purinyl)octane (VII), and 1,12-bis(6-chloro-9-purinyl)dodecane (VIII) were prepared by acid-catalyzed reaction of the corresponding pyrimidines III-V with triethyl orthoformate in N,N-dimethylacetamide. The polymethylene chain-bridged 6-hydroxy-8-azapurines XII-XIV were obtained via diazotization of the corresponding pyrimidines. The spectral data and other physical properties of the new compounds have been determined.
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Pitucha, Monika, Agnieszka Korga-Plewko, Pawel Kozyra, Magdalena Iwan, and Agnieszka A. Kaczor. "2,4-Dichlorophenoxyacetic Thiosemicarbazides as a New Class of Compounds against Stomach Cancer Potentially Intercalating with DNA." Biomolecules 10, no. 2 (February 13, 2020): 296. http://dx.doi.org/10.3390/biom10020296.

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Thiosemicarbazide is a useful structural moiety that has the biological potential. Optimization of this structure can result in groundbreaking discovery of a new class of therapeutic agents. In the light of this, 1-(2,4-dichlorophenoxy)acetyl-4-(1-naphthyl)thiosemicarbazide (1) and 1,4-bis[(2,4-dichlorophenoxy)acetylthiosemicarbazide]phenyl (2) were synthesized and characterized by spectroscopic method. Cytotoxicity of obtained compounds was evaluated on MKN74 gastric cancer cell line and human skin fibroblast BJ based on methylthiazolyldiphenyl-tetrazolium bromide (MTT) test. The apoptosis/necrosis and cell cycle analysis were conducted using image cytometry. Additionally, in DNA of treated cells, abasic sites (AP) and double strands breaks (DSB) presence were measured. Intercalating properties of active compounds were evaluated using the UV–spectroscopic method. Among newly synthesized derivatives, compound 2 showed toxic effects on gastric cancer cells with simultaneous lack of toxicity to normal fibroblasts. Cell cycle analysis revealed that both compounds influence cell division mainly at the stage of replication. Simultaneously with DNA synthesis disorders, DNA damages like AP-sites and DSBs were observed. Spectroscopic studies revealed possible DNA intercalating properties of tested compounds. Obtained results indicate that the newly synthesized thiosemicarbazide derivatives are a promising group of compounds with potential anticancer activity resulted from interactions with DNA and cell cycle interrupt.
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Hegedus, Louis S., Marc M. Greenberg, Jory J. Wendling, and Joseph P. Bullock. "Synthesis of 5,12-Dioxocyclam Nickel (II) Complexes Having Quinoxaline Substituents at the 6 and 13 Positions as Potential DNA Bis-Intercalating and Cleaving Agents." Journal of Organic Chemistry 68, no. 11 (May 2003): 4179–88. http://dx.doi.org/10.1021/jo020708r.

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Dallocchio, Roberto, Alessandro Dessi, Vanna Sanna, Nicolino Pala, Ilaria Campesi, Giuseppe Paglietti, and Mario Sechi. "DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents." Letters in Drug Design & Discovery 6, no. 4 (June 1, 2009): 246–51. http://dx.doi.org/10.2174/157018009788452537.

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Dissertations / Theses on the topic "DNA bis-intercalating agents"

1

Léon, Pascale. "Etudes de relations structure-activite dans la serie des dimeres de 7h-pyridocarbazole, agents antitumoraux bis-intercalants de l'adn." Paris 6, 1987. http://www.theses.fr/1987PA066487.

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2

(9874484), PJP Foley. "DNA bis-intercalators: Design, synthesis and DNA binding properties of potential anti-cancer agents based on rigid polynorbornyl molecular scaffolds." Thesis, 2001. https://figshare.com/articles/thesis/DNA_bis-intercalators_Design_synthesis_and_DNA_binding_properties_of_potential_anti-cancer_agents_based_on_rigid_polynorbornyl_molecular_scaffolds/13423973.

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DNA bis-intercalating agents constitute an important class of compounds for cancer chemotherapy. The work presented in this dissertation deals with the synthesis of a new class of DNA bis-intercalating agents of type I containing rigid polynorbomyl molecular frameworks. The highly rigid molecular framework is designed to place and orient the two intercalating chromophores (the DNA-reactive entities) optimally for specific binding to a known nucleotide sequence. The chromophores are attached to the rigid framework via short flexible tethers, allowing some degree of conformational mobility while maintaining well-defined maximum and minimum inter-chromophore separations. A modular approach to synthesis has been adopted to prepare the bis-intercalators that involved initial preparation of a series of complementary A-BLOCKs II and B-BLOCKIII (Scheme I), each of which contains one intercalating chromophore. These BLOCKs contain different end-functionality (A-BLOCK: alkene; B-BLOCK: epoxide) which react with each other stereospecifically, but not with themselves to produce the desired product IV. The wide range of topologically well defined products generated by this approach show variations which include spacer length, chromophore type and nature of the tether joining the chromophores to the rigid molecular framework. In particular, the BLOCK approach has permitted the preparation of the most comprehensive range of asymmetrical bis-intercalators containing rigid spacers yet described. Representative products derived from this methodology, include the bisacridine V and the acridine-naphthalimide mixed derivative VI. In addition, significant advances have been made to control the hydrophilicity of these drugs, thereby enhancing the bio-compatibility of these novel molecules. DNA binding experiments have been performed on the bis-intercalators prepared in this study. Polynucleotide structural selectivity was observed and sequence-selectivity was associated with the binding of two of the compounds with the highest affinity for DNA. Some features that enhance binding selectivity and affinity have been identified so that the synthesis of more selective compounds for effective gene targeting in chemotherapy can proceed in the future. The results which have helped to define more clearly the parameters of drug-DNA interaction represent a good example of how organic chemistry can be a useful tool to help elucidate and understand biological phenomena. The ground work has been completed providing a solid foundation from which the preparation of novel synthetic targets of medicinal interest using the BLOCK coupling concept can now be approached with less trepidation.
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