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Relevant bibliographies by topics / DNA-compatible reactions

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Journal articles

Academic literature on the topic 'DNA-compatible reactions'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "DNA-compatible reactions"

1

Shi, Ying, Yan-ran Wu, Jian-qiang Yu, Wan-nian Zhang, and Chun-lin Zhuang. "DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output." RSC Advances 11, no. 4 (2021): 2359–76. http://dx.doi.org/10.1039/d0ra09889b.

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We summarize a series of novel DNA-compatible chemistry reactions for DNA-encoded chemical library (DEL) building blocks and analyse the druggability of screened hit molecules via DELs in the past five years.

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2

Fan, Zhoulong, Shuai Zhao, Tao Liu, et al. "Merging C(sp3)–H activation with DNA-encoding." Chemical Science 11, no. 45 (2020): 12282–88. http://dx.doi.org/10.1039/d0sc03935g.

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3

Tran-Hoang, Nam, та Thomas Kodadek. "Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions". ACS Combinatorial Science 20, № 2 (2018): 55–60. http://dx.doi.org/10.1021/acscombsci.7b00151.

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4

Shu, Keitou, та Thomas Kodadek. "Solid-Phase Synthesis of β-Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions". ACS Combinatorial Science 20, № 5 (2018): 277–81. http://dx.doi.org/10.1021/acscombsci.8b00001.

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5

Favalli, Nicholas, Gabriele Bassi, Tania Zanetti, Jörg Scheuermann, and Dario Neri. "Screening of Three Transition Metal‐Mediated Reactions Compatible with DNA‐Encoded Chemical Libraries." Helvetica Chimica Acta 102, no. 4 (2019): e1900033. http://dx.doi.org/10.1002/hlca.201900033.

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6

Liu, Wentao, Wei Huang, Qian Lin, et al. "Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide." Bioorganic & Medicinal Chemistry 38 (May 2021): 116118. http://dx.doi.org/10.1016/j.bmc.2021.116118.

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7

Wang, Jie, Helena Lundberg, Shota Asai, et al. "Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA." Proceedings of the National Academy of Sciences 115, no. 28 (2018): E6404—E6410. http://dx.doi.org/10.1073/pnas.1806900115.

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DNA-encoded libraries (DEL)-based discovery platforms have recently been widely adopted in the pharmaceutical industry, mainly due to their powerful diversity and incredible number of molecules. In the two decades since their disclosure, great strides have been made to expand the toolbox of reaction modes that are compatible with the idiosyncratic aqueous, dilute, and DNA-sensitive parameters of this system. However, construction of highly important C(sp3)−C(sp3) linkages on DNA through cross-coupling remains unexplored. In this article, we describe a systematic approach to translating standar

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8

Kundu, Nandini, Brian E. Young, and Jonathan T. Sczepanski. "Kinetics of heterochiral strand displacement from PNA–DNA heteroduplexes." Nucleic Acids Research 49, no. 11 (2021): 6114–27. http://dx.doi.org/10.1093/nar/gkab499.

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Abstract Dynamic DNA nanodevices represent powerful tools for the interrogation and manipulation of biological systems. Yet, implementation remains challenging due to nuclease degradation and other cellular factors. Use of l-DNA, the nuclease resistant enantiomer of native d-DNA, provides a promising solution. On this basis, we recently developed a strand displacement methodology, referred to as ‘heterochiral’ strand displacement, that enables robust l-DNA nanodevices to be sequence-specifically interfaced with endogenous d-nucleic acids. However, the underlying reaction – strand displacement

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9

Qu, Yi, Huanan Wen, Rui Ge, et al. "Copper-Mediated DNA-Compatible One-Pot Click Reactions of Alkynes with Aryl Borates and TMS-N3." Organic Letters 22, no. 11 (2020): 4146–50. http://dx.doi.org/10.1021/acs.orglett.0c01219.

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10

Whang, I., J. Lee, and M. Jayaram. "Active-site assembly and mode of DNA cleavage by Flp recombinase during full-site recombination." Molecular and Cellular Biology 14, no. 11 (1994): 7492–98. http://dx.doi.org/10.1128/mcb.14.11.7492.

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A combination of half-site substrates and step arrest mutants of Flp, a site-specific recombinase of the integrase family, had earlier revealed the following features of the half-site recombination reaction. (i) The Flp active site is assembled by sharing of catalytic residues from at least two monomers of the protein. (ii) A Flp monomer does not cleave the half site to which it is bound (DNA cleavage in cis); rather, it cleaves a half site bound by a second Flp monomer (DNA cleavage in trans). For the lambda integrase (Int protein), the prototype member of the Int family, catalytic complement

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