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Dissertations / Theses on the topic 'DNA-Directed DNA Polymerase/genetics'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Burrows, Judith Ann. "DNA polymerase from Bacillus caldotenax." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359180.

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2

Burton, Sara Katherine. "DNA-binding proteins associated with DNA polymerase alpha in pea (Pisum sativum)." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357961.

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3

Talanian, Robert Vincent. "Development of Selective Inhibitors of DNA Polymerase Delta: A Thesis." eScholarship@UMMS, 1989. https://escholarship.umassmed.edu/gsbs_diss/66.

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This thesis is divided into three parts, united by the theme of the development of selective inhibitors of mammalian cell DNA polymerase delta (pol δ). The first part consists of an investigation of the cytotoxic mechanism(s) of certain 2-substituted adenine analogs, selected on the basis of their inhibitory properties towards DNA polymerase alpha (pol α) and mammalian cell DNA synthesis. The second is a direct search for inhibitors of isolated pol δ, and an investigation of inhibitory mechanisms. The third consists of measurement of the effects of a selective pol δ inhibitor on cellular DNA s

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4

Caird, Mandy Ruth. "Molecular cloning studies on DNA polymerase alpha." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292388.

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The DNA polymerase α assay systems and partial purification techniques already in use in the laboratory were improved by isolating better-activated DNA and freezing cells prior to sonication. The suitability of monoclonal antibodies against <i>Xenopus laevis</i> and human KB cell (Tanaka <i>et al</i>., 1982) DNA polymerase α was established as a prelude to screening expression libraries. All were found to inhibit polymerase activity by approximately 50%. Two out of three anti-<i>Xenopus laevis</i> DNA polymerase α antibodies and three out of four anti-human DNA polymerase α antibodies bound an

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5

Stenbak, Carolyn Rinke. "Foamy virus polymerase : enzymatic activities and assembly /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/11510.

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6

Stumpf, Jeffrey D. "Polyphosphate kinase regulates DNA polymerase IV in Escherichia coli." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3253637.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007.<br>Title from PDF t.p. (viewed Nov. 19, 2008). Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0748. Adviser: Patricia L. Foster.

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7

Singh, Shivani Shatrughana. "RNA polymerase-DNA interactions at complex gene regulatory regions." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4877/.

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RNA polymerase (RNAP) \(\sigma\) factor must recognise and bind to specific DNA elements, usually AT-rich, in order to initiate transcription. At AT-rich regulatory regions or with more than one \(\sigma\) factor binding site; RNAP has to distinguish between different targets to initiate transcription correctly. At two regulatory regions: i) cbpA regulatory DNA with overlapping binding sites for \(\sigma\)70 and 38 associated RNAP and ii) regulatory region for ehxCABD operon with AT content of 71 %, I examined how correct RNAP binding is ensured. For cbpA regulatory region it was found that t

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8

Tully, Gillian. "DNA profiling for forensic identification : evaluation of polymerase chain reaction methods." Thesis, Cardiff University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264882.

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9

Cloney, Ross. "Involvement of human DNA polymerase kappa in nucleotide excision repair." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/7200/.

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Nucleotide excision repair is one of the major repair pathways responsible for identifying and removing lesions in the DNA double helix. In higher eukaryotes, nucleotide excision repair is a coordinated response of over 30 proteins recruited in an ordered procession with distinct roles in the recognition, removal and repair of said lesions. A key step in the completion of the repair process is the resynthesis of the excised strand using the undamaged partner as a template. DNA polymerase kappa (polκ), a member of the Y-family, has been shown to have a role in nucleotide excision repair distinc

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10

Sikorsky, Jan A. "Effect of DNA base modification on polymerase chain reaction efficiency and fidelity." Huntington, WV : [Marshall University Libraries], 2005. http://www.marshall.edu/etd/descript.asp?ref=554.

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11

Whiting, Sam H. "Studies into the characteristics and mechanism of strand displacement synthesis by retroviral reverse transcriptase /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/11494.

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12

Nordvarg, Helena. "Functional Significance of Multiple Poly(A) Polymerases (PAPs)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5285-X/.

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13

Gardella, Thomas James. "A Genetic Analysis of RNA Polymerase-Promoter Interactions: A Thesis." eScholarship@UMMS, 1988. http://escholarship.umassmed.edu/gsbs_diss/200.

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Transcription initiation is a key step at which gene expression can be regulated. The sigma subunit of RNA polymerase provides the enzyme with the ability to recognize promoter sequences and initiate transcription at specific sites on the chromosome. The molecular basis of sigma function is not well known. It has been suggested that sigma factors confer promoter specificty by making direct contacts to the promoter DNA (Losick and Pero, 1981). To test this idea, suppressors of promoter down mutations were sought that affected the promoter recogniton properties of the σ70 subunit of E. coli RNA

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14

Van, Winkle Carolyn. "Forensic DNA Extraction Strategies for PCR Analysis." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc278269/.

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There is a transition nationwide on the analysis of forensic evidentiary stains containing biological material from traditional serology to Polymerase Chain Reaction (PCR) methodologies. The increased sensitivity of PCR, the limited number of alleles at each locus, and the necessity of producing unambiguous data for entry into the FBI's Combined DNA Index System make this study of extraction procedures of utmost importance. A "single tube" extraction procedure for blood stains collected onto FTA™ paper and a modified differential nonorganic extraction method from spermatozoa containing mixed

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15

Butler, Michelle Marie. "Probing the dNTP Binding Region of Bacillus subtilis: DNA Polymerase III with Site-Directed Inhibitors: A Dissertation." eScholarship@UMMS, 1992. https://escholarship.umassmed.edu/gsbs_diss/132.

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6-(p-Hydroxyphenylhydrazino) uracil (H2-HPUra) is a selective and potent inhibitor of the replication-specific DNA polymerase III (pol III) of Gram+ bacteria such as Bacillus subtilis. Although a pyrimidine, H2-HPUra derives its inhibitory activity from its specific capacity to mimic the purine nucleotide, dGTP. The project described in this thesis dissertation involves the use of H2-HPUra-like inhibitors to probe the structure and function of the pol III active site. It consists of two separate problems which are summarized below. Production of a potent bona fide dGTP form of inhibitor. A me

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16

Chan, Kara Y. "MECHANISMS OF TRINUCLEOTIDE REPEAT INSTABILITY DURING DNA SYNTHESIS." UKnowledge, 2019. https://uknowledge.uky.edu/toxicology_etds/29.

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Genomic instability, in the form of gene mutations, insertions/deletions, and gene amplifications, is one of the hallmarks in many types of cancers and other inheritable genetic disorders. Trinucleotide repeat (TNR) disorders, such as Huntington’s disease (HD) and Myotonic dystrophy (DM) can be inherited and repeats may be extended through subsequent generations. However, it is not clear how the CAG repeats expand through generations in HD. Two possible repeat expansion mechanisms include: 1) polymerase mediated repeat extension; 2) persistent TNR hairpin structure formation persisting in the

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17

Pessoa-Brandão, Luis. "Genetic and molecular studies of Saccharomyces cerevisiae Cdc7-Dbf4 kinase function in DNA damage-induced mutagenesis /." Connect to full text via ProQuest. IP filtered, 2005.

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18

Rudd, Sean G. "Cellular and biochemical characterisation of PrimPol, a novel eukaryotic primase-polymerase involved in DNA damage tolerance." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/45543/.

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Genome stability is of upmost importance to life. DNA polymerases are essential for the duplication and maintenance of the genome but they cannot themselves begin synthesis of a DNA chain, and require the activity of specialised RNA polymerases called primases. In eukaryotic cells distinct enzymes catalyse these two essential processes. This thesis contains the characterisation of coiled-coil domain containing protein (CCDC)111, a previously uncharacterised protein conserved in a broad range of unicellular and multicellular eukaryotes including humans. CCDC111 is a member of the archaeaoeukaro

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19

Bianchi, Julie. "Investigating the role of a novel primase-polymerase, PrimPol, in DNA damage tolerance in vertebrate cells." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/45544/.

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Genome duplication is an essential task our cells have to achieve prior to cell division, and requires a highly specialized replication machinery to ensure it is performed in an accurate and complete manner. DNA primase and polymerases are essential components of the replisome. Primases initiate DNA replication by synthesising short RNA primers that are then elongated by faithful and processive replicative DNA polymerases. However, both exogenous and endogenous agents can damage DNA and hinder progression of the replicative machinery. Translesion synthesis DNA polymerases assist in bypassing t

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20

Tan, Angela Y. C. "The development of an efficient method of mitochondrial DNA analysis." Monash University, Dept. of Forensic Medicine, 2003. http://arrow.monash.edu.au/hdl/1959.1/9525.

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21

Keen, Benjamin A. "Molecular dissection of PrimPol, a novel primase-polymerase involved in damage tolerance during DNA replication in eukaryotic cells." Thesis, University of Sussex, 2015. http://sro.sussex.ac.uk/id/eprint/54095/.

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PrimPol is a recently identified member of the archaeo-eukaryotic primase (AEP) family of proteins. It possesses both primase and polymerase activities and is involved in the replication of both nuclear and mitochondrial DNA. PrimPol is predicted to possess an AEP polymerase and a UL52-like zinc finger domain. This thesis establishes the roles of these domains in the context of PrimPol's catalytic activities. Although apparently dispensable for polymerase activity, the zinc finger is essential for maintaining primase activity and also appears to play an important role in regulating the process

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22

Kasu, Mohaimin. "Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system." University of the Western Cape, 2019. http://hdl.handle.net/11394/6760.

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Philosophiae Doctor - PhD<br>DNA profiling the male specific region on the Y-chromosome is fundamental to forensic practise. Its recognised as a powerful analytical tool for investigation of sexual assault when the DNA evidence is highly admixed. Standard practises for processing sexual assault evidence include physically separate the sperm cell from the female fraction using differential extraction followed by autosomal DNA profiling. However, under specific scenarios of assault physical separation may not be possible due to the nature of the evidence. The research presented in this thesis w

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23

Kelleher, Colleen Diane. "Characterization of polymerase and RNase H activities of Moloney murine leukemia virus reverse transcriptase in relation to models for retroviral plus-strand synthesis /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/11519.

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24

Pacheco, Ana Claudia. "Emprego de miniSTRs \"non-CODIS\" em amostras biológicas de DNA forense." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-01032011-181049/.

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Foram analisadas 80 amostras de casos forenses criminais do Laboratório de DNA do Instituto de Criminalística de São Paulo. O DNA foi extraído de materiais cadavéricos, vestígios de crimes sexuais e de locais de crimes. A quantificação se deu por PCR em tempo real e a amplificação por PCR, em 2 reações triplex, dos miniSTRs non-CODIS D10S1248, D14S1434 e D22S1045 (NCO01) e D1S1677, D2S441 e D4S2364 (NCO02), com posterior eletroforese capilar para detecção dos produtos fluorescentes. Avaliou-se o grau de conservação das amostras e a qualidade dos perfis genéticos obtidos. Houve concordância nas

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25

Palmer, Matthew T. "The influence of retroviral codon usage on the acquisition of the tRNA used to prime reverse transcription." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. https://www.mhsl.uab.edu/dt/2007r/palmer.pdf.

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26

Bedoya, Felipe. "Identification and Characterization of Mitochondrial Genome Concatemers in AIDS-Associated Lymphomas and Lymphoma Cell Lines." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003030.

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27

Ostler, Jeffery Brent Jr. "Characterization of Pol IV and Pol V-Dependent Non-Coding RNAs Derived from aGeminivirus Genome." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492698361649423.

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28

Borgiel, Björn. "En studie för att kontrollera känsligheten av primers för lake (Lota lota), lax (Salmo salar) och öring (Salmo trutta)." Thesis, Karlstads universitet, Institutionen för miljö- och livsvetenskaper (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-67611.

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eDNA is a fast and popular method to collect information about species presence in the environment. eDNA is DNA that is collected from environmental samples, such as water, from DNA that is expelled from organisms interacting with their environment. eDNA is an effective way to find species with small populations and alien species. There are two ways to analyze eDNA, with high-throughput DNA sequencing methods and DNA metabarcoding or use of species-specific primers and PCR. In this study, we focus on the latter, designing species-specific primers for Burbot, Brown trout, and Atlantic Salmon, t

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29

Vasale, Jessica J. "Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/481.

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The RNA interference (RNAi) pathway in Caenorhabditis elegans is a two-step, small RNA-mediated silencing pathway. Unlike in other organisms, Dicer processing of double-stranded RNA into small interfering (si) RNAs is not sufficient in worms to induce gene silencing. The activity of cellular RNA-dependent RNA polymerase (RdRP) is necessary to synthesize a secondary pool of siRNAs, which interact with a unique class of Argonaute proteins to form the functional effector complexes that mediate silencing. The aims of this thesis were to: 1) characterize the role of RdRP family members in endogenou

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30

Patel, Premal Harshad. "Evolution of DNA polymerase active site /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/6361.

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31

Gigli, Elena. "Evolutionary genetics of homo neanderthalensis :adaptive traits and methodological problems." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/77656.

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The evolutionary history of H. neanderthalensis, interwoven with that of H. sapiens, has always fascinated the scientific world. Recent adavncess in paleogenetics shedds new light on the phylogenetic relationship between Neandertals and modern humans. The studies developed in this thesis intend principally to control the contaminants through the development of an anti-contamination protocol for decreasing the human contamination in pre-laboratory phases. We designed a PCR-based method specific for reducing human contamination during the laboratory analysis, and we analyzed the fragmentation pa

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32

Nayak, Dhananjaya. "Conformational mechanisms in T7 RNA polymerase transcription a dissertation /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=44&CISOBOX=1&REC=11.

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33

Lamble, Sarah. "Directed evolution of Thermus aquaticus DNA polymerase by compartmentalised self-replication." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507743.

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The thermophilic enzyme, Thermus aquaticus (Taq) DNA polymerase, is an essential tool in molecular biology because of its ability to synthesis DNA in vitro and its inherent thermal stability. Taq DNA polymerase is widely used in the polymerase chain reaction (PCR), an essential technique in a broad range of different fields from academic research to clinical diagnostics. The use of PCR-based tests in diagnostic testing is ever increasing; however, many of the samples being tested contain substances that inhibit PCR and prevent target amplification. Many attempts have been made to engineer poly

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34

Loh, Ern. "Dissecting genetic and structural determinants of accurate DNA synthesis by DNA polymerase I /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5007.

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35

Tuusa, J. (Jussi). "Human DNA polymerase ε:expression, phosphorylation and protein-protein interactions". Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265815.

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Abstract DNA replication is a process in which a cell duplicates its genome before cell division, and must proceed accurately and in organized manner to guarantee maintenance of the integrity of the genetic information. DNA polymerases are enzymes that catalyse the synthesis of the new DNA strand by utilizing the parental strand as a template. In addition to chromosomal replication, DNA synthesis and therefore DNA polymerases are also needed in other processes like DNA repair and DNA recombination. The DNA polymerase is an essential DNA polymerase in eukaryotes and is required for chr

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36

Maisonneuve, Caroline. "Effets des analogues de la thymidine sur l'oxydation des acides gras chez la souris : implication dans la physiopathologie de la lipoatrophie." Paris 5, 2004. http://www.theses.fr/2004PA05N046.

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Les inhibiteurs nucléosidiques de la transcriptase inverse (INTIs) sont des médicaments anti-VIH pouvant induire des lipodystrophies. Le but de cette thèse a été d'évaluer les effets mitochondriaux et métaboliques des INTIs (AZT, d4T, ddC,ddI, 3TC chez la souris. Après deux semaines de traitement, seuls les analogues de la thymide (AZT et d4T) augmentaient l'oxydation hépatique des acides gras et les corps cétoniques plasmatiques, sans induire un dysfonctionnement mitochondrial profond. Ces effets étaient reproduits par l'acide β-aminoisobutyrique (BAIBA), un catabolite de la thymine. Après si

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37

Mann, Melissa. "Genetic and biochemical recombination studies of a vaccinia DNA polymerase mutant." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0002/MQ43184.pdf.

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38

Gerendasy, Dan Douglas. "The genomic organization and right early transcription of bacteriophage PRD1." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184884.

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The bacteriophage PRD1 is a lipid bearing phage that infects a wide variety of gram-negative bacteria, including Escherichia coli and Salmonella typhimurium when they harbor the appropriate plasmid. It contains a linear duplex DNA molecule that is covalently bound by its 5' ends to a terminal protein. Like adenovirus and the Bacillus phage φ29, PRD1 specifies its own DNA polymerase which is able to utilize the phage encoded terminal protein to prime DNA synthesis. In addition to these two proteins, PRD1 also specifies an additional replication protein (p12) of unknown function. We have sequenc

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39

Amiott, Elizabeth Anne. "A model for the carbon source regulation of yeast mitochondrial transcription /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 100-113). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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40

Feghoul, Linda. "Mécanismes d'action et de résistance des Adénovirus C au Brincidofovir." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC303/document.

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Les adénovirus humains (HAdV) sont responsables d’une importante morbidité et mortalité chez les patients receveurs de cellules souches hématopoïétiques (CSH), en particulier chez les enfants. Le brincidofovir (BCV) prodrogue du cidofovir est un analogue de la cytosine. Il inhibe l’activité de l’ADN polymérase (ADN pol) des HAdV par arrêt de l’élongation et compétition avec les nucléotides naturels. Les objectifs de ce travail sont d’étudier la diversité génétique de l’ADN pol des HAdV et de mettre en place des outils pour l’analyse de la sensibilité des HAdV C et de résistance aux BCV. Dans u

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41

Jackson, Constanza. "Synthesis of 2’ Modified Primers to Characterize Extension Events by Mutant Taq DNA Polymerases." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/592.

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Oligonucleotides enable many biotechnological applications; however they are easily degraded by nucleases. Many nucleotides modified at the 2’ position are degraded at decreased rates which improves oligonucleotide utility. Most applications of oligonucleotides rely on enzymatic synthesis. Unfortunately, native DNA polymerases do not recognize most useful modified nucleotide substrates. Directed evolution has been used to identify mutants of Taq DNA polymerase I (Taq) that recognize substrates with 2’ modifications. While mutant enzymes capable of modified nucleotide addition have been identif

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42

Dahl, Fredrik. "Selector Technology : For Multiplex DNA Analysis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5921.

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43

Nanassy, Oliver Zoltan. "Genetic and biochemical analysis of the Salmonella typhimurium Hin DNA recombinase /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/11525.

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44

Marsiglia, Júlia Daher Carneiro. "Estudo genético de pacientes portadores de cardiomiopatia hipertrófica." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-01112013-112638/.

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Introdução: A cardiomiopatia hipertrófica (CH) é uma doença genética cardíaca primária, caracterizada por hipertrofia do ventrículo esquerdo, sem dilatação, geralmente assimétrica e predominantemente septal, com prevalência estimada em 1:500. Atualmente já foram descobertos 20 genes associados à doença, mas os genes mais frequentemente relacionados são o da Cadeia Pesada da ?-miosina (MYH7), Proteína C de Ligação da Miosina (MYBPC3) e Troponina T (TNNT2). O diagnóstico molecular dos pacientes é importante e custo-efetivo do ponto de vista de saúde pública, além de recomendado pela Sociedade Eu

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45

Hsieh, Jui-Cheng. "Structure-function analysis of the bacteriophage PRD1 DNA terminal protein: Nucleotide sequence, overexpression, and site-directed mutagenesis of the terminal protein gene." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184974.

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The nucleotide sequence of the PRD1 terminal protein gene has been determined. The coding region for PRD1 terminal protein is 777 base pairs long and encodes 259 amino acid residues (29,326 daltons). The deduced amino acid sequence of PRD1 terminal protein reveals no overall homology with other known terminal proteins or related proteins. A closer examination revealed a highly conserved amino acid sequence, YSRLRT, exist among all identified DNA terminal proteins including PRD1, PZA, Nf, φ29 and adenovirus. This is the first conserved amino acid sequence that has been found in all identified D

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46

Boyko, Oleksandr, and University of Lethbridge Faculty of Arts and Science. "The versatile role of homologous recombination in plant cell : repair of DNA damage, stress-directed genome evolution and foreign DNA integration." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/724.

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Homologous recombination represents a DNA repair pathway. Its role in a plant cell is not limited to double strand break repair. It also extends to genome evolution via rearranging of DNA sequences, and has an important application in foreign DNA integration in the plant genome. Our study demonstrated that effects exerted by stress on homologous recombination and genome stability are not restricted to the exposed generation. The progeny of plants exposed to stress exhibited elevated spontaneous homologous recombination, changes in DNA methylation and higher tolerance to stress. These heritable

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47

Lee, Sally. "Architecture of RNA polymerase II and RNA polymerase III pre-initiation transcription complexes /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9213.

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48

Larkin, Robert M. "Analysis of nuclear DNA-dependent RNA polymerase subunits and tata-binding protein from plants /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821341.

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49

Roupioz, Yoann. "La lésion 2-désoxyribonolactone : étude de la réactivité et des conséquences biologiques de ce dommage de l'ADN." Grenoble 1, 2001. http://www.theses.fr/2001GRE10079.

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La lesion 2-desoxyribolactone est un site abasique de l'adn forme par des rayonnements ultra-violet ou des irradiations gamma, par action d'antibiotiques tels que la neocarzinostatine ou de certains complexes metalliques. Ce dommage a la particularite d'etre alcali-labile et de generer des coupures de brins d'adn. Un des buts du travail presente a ete la mise au point d'une voie de synthese generale et quantitative de cette lesion a partir d'un precurseur photoreactif incorpore dans des oligonucleotides de longueur variable. Les oligonucleotides synthetises constituent un outil de choix pour l

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Lancy, Edward Donald Jr. "Genetic requirements for growth of Salmonella typhimurium lacking the proofreading subunit of DNA polymerase III." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054846339.

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