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Relevant bibliographies by topics / DNA, G-quadruplex, structure

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Dissertations / Theses

Academic literature on the topic 'DNA, G-quadruplex, structure'

Author: Grafiati

Published: 9 March 2023

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Dissertations / Theses on the topic "DNA, G-quadruplex, structure"

1

Rangan, Anupama. "Structural studies of nucleic acids dynamics of RNA pseudoknots and G-quadruplex DNA-ligand interactions /." Access restricted to users with UT Austin EID, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3077362.

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2

Palumbo, SunMi Lee. "Characterization of Secondary DNA Structures Formed in the c-myb and hTERT Promoters and Their Potential Role in the Regulation of Transcription." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194266.

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In this dissertation, the formation of unusual G-quadruplexes in the critical regions of the c-myb and hTERT promoters for control of promoter activity was investigated.The c-myb promoter contains three copies of an almost perfect (GGA)4 sequence. We demonstrate that the each (GGA)4 repeat forms a tetrad:heptad G-quadruplex and any two of the three can intramolecularly dimerize to form T:H:H:T G-quadruplexes. The three T:H:H:T G-quadruplex combinations are of differing degrees of stability and can be further stabilized by G-quadruplex interactive compounds. We also demonstrate that the c-my

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3

Rigo, Riccardo. "The fine architecture of guanine-rich regions within oncogene promoters." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427311.

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Suppression of oncogenes transcription represents an ideal tool to integrate the currently available therapeutics to treat several cancer types and to overcome the potential occurrence of resistance. An experimentally validated mechanism of intervention is represented by the induction/stabilization of G-quadruplex structures in genes promoter by small molecules. G-quadruplexes are DNA non-canonical secondary structures consisting of stacked G-quartets, cyclic arrangements of four guanine residues held together by Hoogsteen hydrogen bonds and stabilized by a central cation. At the moment, none

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4

Lago, Sara. "Investigation of the Role of Dna G-Quadruplex Structures in Human Transcription, Cancer and Viral Infections." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425882.

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The present manuscript contains a report of the research activity conducted for the Ph.D. project regarding the study of DNA G-quadruplex structures in a rare type of human cancer (Liposarcoma) and in the genome of two world-wide spread viruses: HIV-1 and HSV-1.<br>Il manuscritto contiene una descrizione e discussione dei risultati ottenuti in ambito del progetto di ricerca di dottorato riguardante lo studio delle strutture G-quadruplex delDNA in un tumore umani raro (il liposarcoma) e nel genoma di due virus a diffusione mondiale, quali: HIV-1 e HSV-1.

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5

Dexheimer, Thomas Steven. "Defining the Role of DNA Secondary Structures and Transcriptional Factors in the Control of c-myc and bcl-2 Expression." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195655.

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In this dissertation, we explore the transcriptional regulatory roles of Gquadruplex- forming motifs and the involvement of specific transcriptional factors, which interact with the same elements, in the control of human c-myc and bcl-2 gene expression. The G-quadruplex structures within the NHE III1 region of the c-myc promoter and their ability to repress transcription has been well established. However, a longstanding unanswered question is how these stable DNA secondary structures are transformed to activate c-myc transcription. NDPK-B has been recognized as an activator of c-myc transcrip

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6

Qureshi, Mohammad Haroon. "Replication Protein A Mediated G-Quadruplex Unfolding - A Single Molecule FRET Study." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1385984615.

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7

Musetti, Caterina. "SELECTIVE TARGETING OF NUCLEIC ACIDS BY SMALL MOLECULES: A DNA STRUCTURE RECOGNITION APPROACH." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3422045.

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The discovery of new anticancer targets is the key factor for the development of more efficacious therapies. Sequence selective binding of double stranded DNA in the classical B form has been extensively employed to target small molecules to defined polynucleotide portions. More recently, ligand recognition of non canonical DNA foldings has been additionally considered a useful approach to selectively target distinct genomic regions. In this connection, G-quadruplexes represent an interesting system since they are believed to be physiologically significant arrangements. These non-canonical DNA

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8

Kerkour, Abdelaziz. "Study of DNA G-quadruplex structures by Nuclear Magnetic Resonance (NMR)." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0292/document.

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Les G-quadruplexes (G4) sont des structures d'acides nucléiques non-canoniques formées par des séquences riches en Guanines (G) principalement localisées dans les telomères et les régions promotrices des oncogènes. Elles sont constituées de l'empilement de plusieurs tétrades de G en présence de cations. En utilisant la spectroscopie par RMN, nous avons caractérisé l'interaction entre le ligand TAP et le G4 télomérique humain constituée de la séquence d(AG3(T2AG3)3). CD et RMN 1D 1H ont été utilisés pour suivre l'interaction entre les deux partenaires. RMN 2D a été utilisé pour attribuer sans a

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9

Morel, Elodie. "Conception d’outils chimiques pour la détection des structures d’ADN G-quadruplex." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS237.

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Des structures secondaires d’acides nucléiques atypiques, les structures G-quadruplex, peuvent se former autour d’un cation (K+ ou Na+) dans les régions riches en guanines, grâce à une association de type Hoogsteen. La formation de ces structures est impliquée dans de nombreux mécanismes biologiques, comme la réplication, la transcription ou l’épissage. Elles peuvent affecter l’architecture de l’ADN jusqu’au niveau de la chromatine et provoquer une instabilité importante, tant génétique qu’épigénétique. De nombreuses méthodes ont été développées afin de détecter ces structures in vivo et de co

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10

Ma, Yingfang. "Electronic Structure, Optical Properties and Long-Range-Interaction Driven Mesoscale Assembly." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1497049273517057.

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