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Dissertations / Theses on the topic 'DNA hydrolysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Evans, Steven John. "Structure, function and mechanism of action of bovine pancreatic deoxyribonuclease I : role of amino acid residues involved in phosphate contacts." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321857.

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2

Przybylski, Jennifer L., and University of Lethbridge Faculty of Arts and Science. "Computational modeling of the hydrolysis of 2'-deoxyribonucleic acids." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, c2009, 2009. http://hdl.handle.net/10133/1292.

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The mechanism for the hydrolysis of 2′-deoxyribonucleosides is examined using computational chemistry techniques. Initially, a model capable of accurately predicting the mechanism and activation barrier for the uncatalyzed hydrolysis of 2′-deoxyuridine is designed. It is found that the smallest model includes both explicit and implicit solvation during the optimization step. Next, this hybrid solvation model is applied to four natural nucleosides, namely 2′-deoxyadenosine, 2′-deoxycytidine, 2′-deoxyguanosine and thymidine. The hybrid model correctly predicts the trend in activation Gibbs energ

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3

Eissa, Omaima Abdel-Latif Elkotb. "Cloning of a novel operon containing genes for 4-#alpha#-glucanotransferase, maltodextrin phosphorylase, and a regulatory protein from Clostridium butyricum." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296246.

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4

Marrone, April. "THE BIOCHEMICAL REACTIONS OF DRY STATE DNA." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3622.

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The biochemistry of dry state DNA is of interest to the fields of forensics, ancient DNA, and DNA storage. The exact chemical nature of the degradation of the DNA molecule in the dry state has not been studied prior. If determined what chemical changes the DNA molecule undergoes, to what degree and in what time frame then protocols can be implemented to bypass the impact of this damage or to repair it when necessary. It is suspected that similar reactions occur to the dry state DNA molecule as does to the hydrated molecule. It cannot be assumed, however that these types of chemical processes o

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5

Bhat, Anayat [Verfasser]. "Live Cell Fluorescence Imaging of Nucleotide Dynamics : ATP Hydrolysis and DNA Damage Response / Anayat Bhat." Konstanz : KOPS Universität Konstanz, 2021. http://d-nb.info/1229351094/34.

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6

Marin, Córdoba Roberto. "Chromium carcinogenesis characterization of DNA damaging intermediates by EPR ³¹P NMR, HPLC, ESI-MS and magnetic susceptibility /." Ohio : Ohio University, 2010. http://www.ohiolink.edu/etd/view.cgi?ohiou1261417590.

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7

Moysan-Le, Meur Annie. "Caracterisation de dosage des produits de photoaddition de psoralene dans l'adn "in vitro" et dans l'adn cellulaire." Paris 6, 1987. http://www.theses.fr/1987PA066021.

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8

Marin, Cordoba Roberto. "Chromium Carcinogenesis: Characterization of DNA damaging Intermediates by EPR ³¹P NMR, HPLC, ESI-MS and Magnetic Susceptibility." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1261417590.

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9

Taori, Vijay P. "Poly(glycoamidoamine)s: Understanding their Structure and Structure-Bioactivity Relationships." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77982.

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In order to achieve efficient therapeutic effect, it is important to understand the structure of biomaterials that are used in the therapeutic delivery system. This dissertation is dedicated towards understanding the hydrolysis pattern of plasmid DNA (pDNA) delivery vehicles comprised of poly(glycoamidoamine)s (PGAAs) under physiological conditions and effects of subtle changes in the chemical structure of the PGAAs on its biological performance. The unusual hydrolysis of the tartarate and galactarate based PGAAs was investigated by studying the hydrolysis of small model molecules which mimic

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10

Incardona, Marie-Françoise. "Mesure de lésions de type oxydatif de l'ADN dans les fluides biologiques et dans l'ADN isolé." Grenoble 1, 1994. http://www.theses.fr/1994GRE10162.

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Divers facteurs (stress oxydant, exposition a divers rayonnements) peuvent engendrer des modifications des bases de l'adn. La mise au point de methodes d'analyse suffisamment fiables et sensibles nous a permis de detecter et de doser plusieurs dommages oxydatifs dans un fluide biologique (urine humaine) et dans l'adn isole. Pour cela, deux techniques ont ete respectivement mises en uvre: la chromatographie gazeuse couplee a la spectrometrie de masse (cg/sm) et la chromatographie liquide a haute performance associee a une detection electrochimique (clhp/ec). La mise au point de methodes de dete

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11

Zhou, Rong. "Topoisomerase II and drug resistance in leukemic cells /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4738-4/.

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12

Al-Sayed, Mahmoud Kassem. "Extraction, fractionnement et caractérisation des lipides polyinsaturés d'oeufs de la truite arc-en-ciel (Oncorhynchus mykiss)." Thesis, Vandoeuvre-les-Nancy, INPL, 2007. http://www.theses.fr/2007INPL087N/document.

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Parmi les œufs de poisson, qui sont une ressource aquatique nutritionnelle intéressante, ceux de la truite arc-en-ciel (Oncorhynchus mykiss) contiennent une quantité élevée de protéines et une huile riche en acides gras polyinsaturés (AGPI), avec une proportion très importante de phospholipides. Cependant, l’œuf de poisson présente une capacité élevée d’auto-protection contre les contraintes extérieures, qui limite la destructuration de son réseau protéique par attaque enzymatique. Ainsi, le degré d’hydrolyse des œufs de la truite l’Alcalase®, la Neutrase® et la Protamex® varie entre 3 et 7 %,

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13

Maester, Thais Carvalho. "Prospecção de sequências genômicas codificadoras de enzimas lipolíticas degradadoras de hidrocarbonetos de petróleo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-15092011-151851/.

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Enzimas lipolíticas possuem enorme potencial biotecnológico. O objetivo foi prospectar genes para a codificação de enzimas lipolíticas em biblioteca metagenômica com 4224 clones. A atividade lipolítica foi avaliada pela formação de halo ao redor das colônias através do cultivo dos clones em meio de cultura suplementado com tributirina, sendo positiva para 30 clones, e dois foram selecionados e tiveram o DNA sub-clonado. Os DNAs das sub-bibliotecas foram sequenciados, gerando um contig completo para o clone PL28.F10, que foi comparado com as sequências do banco NCBI. Uma ORF codificadora de est

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14

Sioud, Mouldy. "Etude des mecanismes moleculaires d'action des inhibiteurs des adn topoisomerases 2 chez les archaebacteries halophiles." Paris 7, 1988. http://www.theses.fr/1988PA077155.

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15

Pommier, Yves. "Les agents intercalants affectent le fonctionnement des adn topoisomerases deux eukaryotes." Paris 6, 1986. http://www.theses.fr/1986PA066570.

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Parmi les medicaments anticancereux les plus actifs, les agents intercalants de l'adn (anthracyclines, acridines) produisent des lesions sur l'adn de type soit cassure du dna, soit pontage adn-proteine. Ces alterations sont analysees par elution alcaline, sedimentation de nucleotide et sedimentation alcaline. Ces lesions sont reversibles apres suppression des intercalants (culture cellulaire, cellules leuconiques(l1210)). Les dna topoisomerase 2 (enzyme de replication, de transcription, d'organisation de chromatine) sont responsables des lesions provoquees par les agents intercalants du dna, c

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16

Volff, Jean-Nicolas. "Stimulation de l'instabilité génétique et des réarrangements génomiques chez streptomyces ambofaciens." Nancy 1, 1994. http://www.theses.fr/1994NAN10008.

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L’instabilité génétique de la bactérie streptomyces ambofaciens atcc23877 se manifeste par l'apparition de mutants dépigmentés à une fréquence voisine de 0,5%. Certains mutants sont pléiotropes. La majorité des mutants dépigmentés présentent des délétions et des amplifications de grandes séquences d’ADN. Deux mutants présentant une instabilité génétique augmentée ont été isoles. Les rayonnements ultraviolets, la mitomycine c et l'acide nitreux augmentent la fréquence des mutants dépigmentés. De plus, cinq antibiotiques inhibant l'ADN gyrase, la topoisomérase ii bactérienne, induisent de nombre

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17

Amir, Aslani Arsia. "Étude des propriétés structurales d'un site de coupure préférentiel de la topoisomerase II." Paris 6, 1996. http://www.theses.fr/1996PA066454.

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La grande variete des structures d'adn repertoriees, nous permet de penser que ce sont les proprietes conformationnelles de l'adn qui se trouvent a la base des evenements gouvernant la regulation genetique. A l'origine de celle-ci se trouvent les phenomenes de reconnaissance moleculaires : liaison d'un ligand, que ce soit une proteine ou un agent antitumoral, a un domaine particulier de l'adn. L'analyse des sequences au voisinage des principaux sites de clivage de l'adn de pbr322 par la topoisomerase ii de thymus de veau couplee a l'ellipticine a permis de mettre en evidence une sequence conse

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18

CELIA, HERVE. "Etudes structurales de la sous-unite b de la gyrase d'escherichia coli et de l'arn polymerase a de saccharomyces cerevisiae. Microscopie electronique et analyse d'images de cristaux bidimensionnels." Strasbourg 1, 1993. http://www.theses.fr/1993STR13175.

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Des cristaux bidimensionnels de sous-unite b de la gyrase avaient ete obtenus par interaction specifique de la proteine avec un film de lipides greffes covalament a la novobiocine, un inhibiteur des fonctions atpasiques de l'enzyme. Nous avons calcule un modele tridimensionnel de la sous-unite b a partir d'images de cristaux de la proteine colores negativement. Ce modele montre a 2,5-3,0 nm de resolution deux bras allonges formant une structure en v, la base du v contenant le site de liaison a la novobiocine. L'analyse d'images effectuee sur les memes cristaux hydrates congeles a permis de det

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19

VILAREM, PUIG MARIE-JOSE. "Etude des mecanismes d'activite cytotoxique et moleculaire du bd-40, une aza-ellipticine douee de pouvoir antitumoral." Paris 6, 1987. http://www.theses.fr/1987PA066219.

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20

Charcosset, Jean-Yves. "Etude sur le mécanisme d'action de dérivés de l'ellipticine sur des cellules en culture sensibles et résistantes à la 9-hydroxyellipticine." Paris 6, 1986. http://www.theses.fr/1986PA066109.

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21

Fayet, Axel. "Détoxification d'hydolysats hémicellulosiques par dia-nanofiltration, étude de leur fermentescibilité et du mode d'action des inhibiteurs." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLA008/document.

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La biomasse lignocellulosique (BLC) est, à l’heure actuelle, la meilleure alternative au pétrole en ce qui concerne la production d’énergie et de molécules à haute valeur ajoutée. Seulement, son exploitation nécessite l’emploi de prétraitements dont les plus courants génèrent des composés inhibant la croissance des microorganismes (dérivés furaniques, acides aliphatiques, phenols).Le but de ces travaux de thèse est donc de répondre à la question suivante : “Est il possible d’utiliser la nanofiltration pour éliminer les composés inhibiteurs présents dans un hydrolysat hémicellulosique, afin de

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22

BEJAR, SAMIR. "Etudes de la region du terminus du chromosome d'escherichia coli k12 : replication et controle de la division cellulaire." Toulouse 3, 1986. http://www.theses.fr/1986TOU30190.

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23

Mousseau, Mireille. "Étude des mécanismes moléculaires de chimiorésistance intrinsèque des tumeurs cérébrales humaines." Grenoble 1, 1992. http://www.theses.fr/1992GRE10186.

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La chimiothérapie a une faible efficacité sur les tumeurs cérébrales humaines (taux de réponse objective allant de 13 a 33%). Nous avons étudié les mécanismes moléculaires de chimiorésistance intrinsèque sur une série de 66 tumeurs cérébrales humaines comportant 31 gliomes (1 gangliogliome grade 1, 9 astrocytomes grade 2 et 10 grade 3, 11 gliomes grade 4), 18 méningiomes, 12 métastases cérébrales (de 2 cancers bronchiques épidermoïdes; de 8 adénocarcinomes du sein (3 cas), du poumon (2 cas), d'origine indéterminée (2 cas) et du colon (1 cas); d'1 sarcome d'Ewing; d'1 cancer bronchique peu diff

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24

Gate, Laurent. "Influence du degré de méthylation de la daunosamine des anthracyclines dans l'apoptose, l'activité des topoisomérases et la modulation du phénotype de résistance multiple." Rouen, 2000. http://www.theses.fr/2000ROUES005.

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Nous avons étudié sur des cellules érythroleucémiques murines sensibles (FLC) et résistantes (DOX-RFLC) qui surexpriment la P-gp et présentent une diminution de l'expression des topoisomérases II, l'importance de la N-méthylation des anthracyclines dans la modulation de la résistance multidrogue. Ces travaux ont montré que l'augmentation de la N-méthylation de ces agents conduisait à une diminution de l'index de résistance et à une diminution des différences d'incorporation et d'extrusion de ces agents entre cellules DOX-RFLC et FLC. Il fut également observé que les trois molécules inhibaient

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25

Masson, Christophe. "Transfert de gênes cible vers les tumeurs : conception, synthèse et propriétés de nouveaux vecteurs chimiques de l'ADN pour le ciblage des cellules cancéreuses." Paris 6, 2001. http://www.theses.fr/2001PA066166.

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Les lipides cationiques sont parmi les agents chimiques les plus efficaces pour le transfert de gênes in vitro : ils forment avec l'ADN des particules appelées lipoplexes capables de transporter le gêne thérapeutique jusqu'au noyau des céllules. Malheureusement, ces systèmes interagissent non spécifiquement avec les milieux biologiques ce qui résulte en une faible sélectivite et une mauvaise efficacité in vivo. Cette thèse a pour objectif de concevoir des vecteurs chimiques induisant un transfert de gênes sélectif vers les tumeurs après injection intraveineuse. Les voies d'activation du polyet

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26

Tseng, Ta-Sheng Andrew. "Phosphodiester hydrolysis and DNA cleavage with copper (II) macrocycles /." 2002. http://www.library.wisc.edu/databases/connect/dissertations.html.

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27

Huang, Yan-Chen, and 黃彥程. "Study of DNA Hydrolysis by Three-Dimensional Metal Complexes Containing Triazaclyclononane." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/13022040536075978952.

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碩士<br>淡江大學<br>化學學系<br>91<br>DNA hydrolysis reagents developed with synthesis metal complexes have important implications in the field of bioengineering and biomedical science. The new trinuclear metal complex which formed by 1,1,1-tris(hrdroxy methyl)ethane with 3 di-isoTACN complexed with metal ions, can act as strong Lewis acid or strong metal hydroxide group to enhance intramolecular reaction and the hydrolysis of phosphate diester. Using UV spectroscopy to confirm that 3-TACN and lanthanide and transition metal ions can form metal complexes and to determine the interaction among them under

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28

Kim, Jong-Il. "The role of ATP hydrolysis in recA protein-mediated DNA strand exchange." 1993. http://catalog.hathitrust.org/api/volumes/oclc/29766146.html.

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29

Kuska, Michael S. "Structure and Stability of Oxygen-Linked DNA Adducts Derived from Phenolic Toxins." Thesis, 2013. http://hdl.handle.net/10214/6760.

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A significant focus of nucleic acids research is on the reactivity of electrophilic species with DNA to form addition products (adducts). Phenols are known to be able to form adducts at the C8 site of deoxyguanosine (dG). This dissertation studies the oxygen (O)-linked class of phenolic dG adducts for their hydrolytic stability as well as their structural impact on the DNA duplex. To determine the effect of C8 O-linked phenolic dG adducts on glycosidic bond stability spectrophotometric determination of hydrolysis kinetics was performed. The kinetics establish the adducts to be less stable than

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30

Williams, Dominique. "Cleavage of Lipids and DNA by Metal Ions and Complexes." 2014. http://scholarworks.gsu.edu/chemistry_diss/94.

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Metal ions and complexes utilized as cleavage agents have influenced many synthetic approaches of scientists to assist in the cleavage and transformation of biomolecules. These metal-based synthetic cleavage agents have potential applications in biotechnology or as molecular therapeutic agents. Herein, we have examined Ce(IV) metal ion and complexes as acidic hydrolytic agents in lipid hydrolysis reactions (Chapter 2 and 3), and a copper(II) complex that photo-oxidizes DNA upon exposure to ultraviolet light (Chapter 4). In Chapter 2 we examined the hydrolysis of sphingomyelin vesicles by Ce(

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31

"The Q motif is involved in DNA binding that affects ATP hydrolysis and unwinding in ChlR1 helicase." Thesis, 2016. http://hdl.handle.net/10388/ETD-2016-02-2413.

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Helicases are molecular motors that couple the energy of nucleoside triphosphate (NTP) hydrolysis to the unwinding and remodeling of structured DNA or RNA. The conversion of energy derived from NTP hydrolysis into unwinding of double-stranded nucleic acids is coordinated by seven sequence motifs (I, Ia, II, III, IV, V, and VI). The Q motif, consisting of an invariant glutamine (Q) residue, has been identified in some, but not all helicases. Compared with the seven well-recognized conserved helicase motifs, the role of the Q motif is not well known. Mutations in the human ChlR1 (DDX11) gene

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32

Schutte, Brian Charles. "Changes in ATP hydrolysis and DNA topology resulting from the formation of recA protein-generated paranemic complexes." 1988. http://catalog.hathitrust.org/api/volumes/oclc/19903905.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1988.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 187-193).

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33

Kuan, Pu-Yun, and 管佈雲. "Kinetic & Catalytic Activity Study of Lanthanide Complex of DO2A & K21DA in Phosphate Diester & DNA Hydrolysis." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/64199364745414106462.

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碩士<br>國立交通大學<br>生物科技研究所<br>86<br>Deoxyribonucleic acid (DNA) at the natural state is very stable; its half-life is over 100,000,000 years. Therefore, how to promote the DNA's hydrolysis rate becomes a challenge for many biochemists. In the beginning of this thesis, we are using macrocyclic ligand 1,7-bis(carboxymethyl) 1,4,7,10-tetraazacyclododecane (DO2A) and acid-1,7- diaza-4,10,13-trioxacyclopentadecane N,N'-Diacetic (K21DA) and lanthanide ions La(III) and Eu(III) to form complexes, and

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34

Bosgard, Brett R. "The chemistry of coupling 1,4,7-triazacyclononanane to silica and DNA : preparation and study of materials to promote phosphate ester hydrolysis and preparation of compounds to study DNA bending /." 2002. http://www.library.wisc.edu/databases/connect/dissertations.html.

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35

Zhao-YiChang and 張兆毅. "para-Pyridinium Chromophore of Green Fluorescence Protein Analogue：Synthesis, Photo/Thermal Isomerization, Acidic Hydrolysis and Discussion the Mechanism of Intercalation with DNA." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/hsd7x2.

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36

Madeira, Catarina Alexandra Catanas. "Activity of the major autolysin of Staphylococcus aureus Atl in the presence of extracellular DNA." Master's thesis, 2018. http://hdl.handle.net/10362/53142.

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37

Starkuviene, Vytaute. "Identifizierung und Charakterisierung von thermostabilen Uracil Glykosylasen von Archaeon Methanobacterium thermoautotrophicum und Bakterium Thermus thermophilus." Doctoral thesis, 2001. http://hdl.handle.net/11858/00-1735-0000-0006-AC13-A.

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38

Lee, Crystal J. J. "Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis." Thesis, 2012. http://hdl.handle.net/1807/36210.

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The expanding therapeutic use of thalidomide (TD) remains limited by its species-specific teratogenicity in humans and rabbits, but not rodents. The R and S isomers of TD may be selectively responsible for its respective therapeutic and teratogenic effects, but rapid in vivo racemization makes this impossible to confirm. Fluorothalidomide (FTD), a fluorinated TD analogue with stable, non-racemizing isomers, may serve as a model compound for determining stereoselective effects. In vivo, FTD was undetectable in plasma, suggesting rapid breakdown, as confirmed in vitro, where FTD hydrolyzed u

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39

Ward, Ian M., S. P. Hill, P. G. Klein, J. Rose, De Oca H. Montez, and D. Farrar. "Dynamic mechanical studies of hydrolytic degradation in isotropic and oriented Maxon B." 2009. http://hdl.handle.net/10454/3171.

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No<br>Hydrolytic degradation studies have been undertaken on Maxon B, a bioresorbable block copolymer of polyglycolic acid (PGA) and polytrimethylene carbonate (TMC). Isotropic and oriented samples were studied by dynamic mechanical measurements over a wide range of temperatures. In addition to mechanical tests, water content and mass loss were also determined on the degraded samples. At early stages of degradation water content was the dominant factor and plasticisation lead to reductions in the glass transition temperatures of the PGA and TMC components. Orientation was shown to give signifi

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40

陳家翎. "Kinetics studies of lanthanide polyaza polycarboxylate macrocyclic complexes Ln(DO2A) and their applications in DNA/RNA hydrolytic scission." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/47863230735046783905.

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碩士<br>國立交通大學<br>生物科技研究所<br>88<br>ENGLISH ABSTRACT Since the first wholly synthetic artificial ribozyme was published in 1994, DNA and RNA whose half-life is very long can also be degradation in the short time. Therefore, it took scientists’ attention and researches, and is to promote the DNA’s or RNA’s hydrolysis rate became a challenge for many biochemists. Because the artificial restriction enzyme may be applied for gene engineering and probably provided a more effective and harmless cure. In the beginning of this thesis, we are using macrocyclic ligand 1,7-bis(carboxym

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41

Rankin, Katherine M. "Structure and Properties of C8-Aryl-2'-Deoxyguanosine Adducts: From Mutagenic Lesions to Conformational Probes in Duplex DNA." Thesis, 2012. http://hdl.handle.net/10214/4935.

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A significant focus of toxicological research is the identification of electrophiles that covalently modify DNA to form addition products (adducts). These products can be generated when aryl radical species react at the C8-site of 2'-deoxyguanosine (dG) to form C8-aryl-dG adducts, which are mutagenic lesions. While this form of DNA modification is detrimental, C8-aryl-dG adducts also possess intriguing properties that can be exploited for beneficial purposes. This thesis is an investigation of one mechanism believed to contribute to the mutagenicity of C8-aryl-dG adducts, as well as a study

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