Academic literature on the topic 'DNA intercalating ligand'

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Journal articles on the topic "DNA intercalating ligand"

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Mamasakhlisov, A. Ye, and Ye Sh Mamasakhlisov. "THE CONDUCTIVITY OF THE MONOLAYER OF COMPLEXES OF DNA WITH QUANTUM DOTS IN THE PRESENCE OF INTERCALATING LIGANDS." Proceedings of the YSU A: Physical and Mathematical Sciences 53, no. 3 (250) (2019): 203–7. http://dx.doi.org/10.46991/pysu:a/2019.53.3.203.

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The noncompetitive DNA hybridization and conductivity in the presence of non-charged ligands have been investigated and the comparison is made with the ligand-free case. It has been shown that the intercalating ligands enhance the sensitivity of the DNA chips as compared with the ligand-free case at the high enough concentration of ligands.
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Sharma, Nitin Kumar, Rakesh Kumar Ameta, and Man Singh. "Biological Impact of Pd (II) Complexes: Synthesis, Spectral Characterization, In Vitro Anticancer, CT-DNA Binding, and Antioxidant Activities." International Journal of Medicinal Chemistry 2016 (February 16, 2016): 1–10. http://dx.doi.org/10.1155/2016/9245619.

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A new series of Pd (II) complexes of methyl substituted benzylamine ligands (BLs) has been synthesized and characterized via spectroscopic techniques such as UV/Vis. FTIR, LCMS, 1H, and 13C NMR. The UV/Vis study in DMSO, DMSO + water, and DMSO + PBS buffer (pH = 7.2) confirmed their molecular sustainability in liquids. Their in vitro anticancer activity against breast cancer cell lines such as MCF-7 and MDA-MB-231 makes them interesting for in vivo analysis. Their stronger DNA binding activity (DBA) compared with free ligand suggested them as a good DNA binder. DBA was further confirmed by phy
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Nardo, Luca, Maria Bondani, and Alessandra Andreoni. "Discrimination of the binding mode of DNA ligands by single-photon timing." Spectroscopy 23, no. 1 (2009): 11–28. http://dx.doi.org/10.1155/2009/605756.

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We perform time-correlated single-photon counting measurements with 30-ps resolution of the fluorescence emitted by the donor fluorophores of donor–acceptor pairs covalently labeling DNA synthetic oligonucleotides by using a non-commercial single-photon avalanche diode. The measurements allow us to precisely assess the fluorescence resonant energy transfer efficiency of the pairs in solutions containing the oligonucleotides and DNA–ligands, for different ratios of the DNA base-pair to ligand concentrations. A quantitative evaluation of the deformations of DNA double strands following the ligan
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Marverti, Gaetano, Gaia Gozzi, Angela Lauriola, et al. "The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cell Lines." International Journal of Molecular Sciences 20, no. 24 (2019): 6122. http://dx.doi.org/10.3390/ijms20246122.

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Ovarian cancer is the most lethal gynecological malignancy, often because of the frequent insurgence of chemoresistance to the drugs currently used. Thus, new therapeutical agents are needed. We tested the toxicity of 16 new DNA-intercalating agents to cisplatin (cDDP)-sensitive human ovarian carcinoma cell lines and their resistant counterparts. The compounds were the complexes of Pt(II) or Pd(II) with bipyridyl (bipy) and phenanthrolyl (phen) and with four different thiourea ancillary ligands. Within each of the four series of complexes characterized by the same thiourea ligand, the Pd(phen)
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Piestrzeniewicz, Mariola K., Dorota Wilmańska, Kazimierz Studzian, et al. "Inhibition of RNA Synthesis in vitro by Acridines - Relation between Structure and Activity." Zeitschrift für Naturforschung C 53, no. 5-6 (1998): 359–68. http://dx.doi.org/10.1515/znc-1998-5-610.

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Abstract The effects of acridine derivatives (proflavine and 2,7-dialkyl derivatives, diacridines and triacridines, 9-aminoacridine carboxamides, and 9-anilinoacridine, amsacrine and its congeners) on overall RNA synthesis in vitro, on synthesis of initiating oligonucleotides and the binding of the enzyme to DNA were studied. The primary mechanism of action is related to inhibition of the enzyme binding to DNA. The acridines (intercalating or non-intercalating and bis-intercalating ligands) assayed here differ in the properties of their complexes with DNA. Correlation is generally observed bet
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McFadyen, W. D., L. P. G. Wakelin, I. A. G. Roos, and B. L. Hillcoat. "Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent." Biochemical Journal 238, no. 3 (1986): 757–63. http://dx.doi.org/10.1042/bj2380757.

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A series of binuclear DNA-binding ligands was prepared by linking two (2,2′:6′,2″-terpyridine)platinum(II) moieties via alpha omega-dithiols of the type HS-[CH2]n-SH where n = 4-10. A monomeric analogue was also synthesized. Compounds were characterized by elemental analysis and electronic and n.m.r. spectroscopy. Viscometric measurements with sonicated rod-like DNA fragments and covalently closed circular DNA were performed to investigate the mode of binding of these agents. The ligands with n = 5 and 6 function as bis intercalators and form a single ‘base-pair sandwich’ in violation of neigh
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Sakthikumar, Karunganathan, Rajadurai Vijay Solomon, and Jeyaraj Dhaveethu Raja. "Spectro-electrochemical assessments of DNA/BSA interactions, cytotoxicity, radical scavenging and pharmacological implications of biosensitive and biologically active morpholine-based metal(ii) complexes: a combined experimental and computational investigation." RSC Advances 9, no. 25 (2019): 14220–41. http://dx.doi.org/10.1039/c8ra09218d.

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Morpholine-based metal(ii) complexes exhibited more significant biological activities than the free ligand. Among investigations towards DNA/BSA, the copper complex revealed excellent intercalating efficacy, which suggests it may have potential as a novel anticancer agent.
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de Oliveira, Tiago Alves, Lucas Rolim Medaglia, Eduardo Habib Bechelane Maia, et al. "Evaluation of Docking Machine Learning and Molecular Dynamics Methodologies for DNA-Ligand Systems." Pharmaceuticals 15, no. 2 (2022): 132. http://dx.doi.org/10.3390/ph15020132.

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DNA is a molecular target for the treatment of several diseases, including cancer, but there are few docking methodologies exploring the interactions between nucleic acids with DNA intercalating agents. Different docking methodologies, such as AutoDock Vina, DOCK 6, and Consensus, implemented into Molecular Architect (MolAr), were evaluated for their ability to analyze those interactions, considering visual inspection, redocking, and ROC curve. Ligands were refined by Parametric Method 7 (PM7), and ligands and decoys were docked into the minor DNA groove (PDB code: 1VZK). As a result, the area
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Mamasakhlisov, Ye Sh, A. P. Antonyan, and A. A. Hakobyan. "EFFECT OF LIGAND BINDING ON FUNCTIONALITY OF DNA FIELD-EFFECT TRANSISTOR." Proceedings of the YSU A: Physical and Mathematical Sciences 51, no. 1 (242) (2017): 66–70. http://dx.doi.org/10.46991/pysu:a/2017.51.1.066.

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Motivated by the prospects of developing DNA field-effect transistors, as tools for a variety of application fields such as medical diagnostics, environmental pollutants monitoring, biological weapons defense, and taking into account that the efficiency of DNA-sensors depends on the precise prediction of experimental parameters responsible for thermostability of nucleic acids duplexes and specific times of formation of DNA duplexes, we analyze the factors influencing both the thermodynamics of hybridization and the stability of DNA–DNA and DNA–RNA duplexes. In this work the case of competition
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Petrosyan, Nara H. "STUDY OF ABSORPTION SPECTRA OF THE COMPLEXES OF BOVINE SERUM ALBUMIN WITH HOECHST 33258 AND METHYLENE BLUE." Proceedings of the YSU B: Chemical and Biological Sciences 55, no. 2 (255) (2021): 158–64. http://dx.doi.org/10.46991/pysu:b/2021.55.2.158.

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The study on the interaction of DNA-specific low-molecular compounds – groove binding material Hoechst 33258 and intercalating ligand methylene blue (MB) with serum albumin has been carried out. The absorption and differential absorption spectra of complexes of the mentioned ligands with protein were obtained. Changes of the absorption and differential absorption spectra indicate the binding of two ligands with albumin. The obtained results indicate that at the interaction with both ligands, the conformational state of the protein alters, though these changes are not similar, since in the case
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Dissertations / Theses on the topic "DNA intercalating ligand"

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Howerton, Shelley B. "Structural characterization of B-DNA and its interactions with cations and intercalating ligands." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/30557.

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Coppel, Yannick. "Études de la structure de complexes ADN-ligand par résonance magnétique nucléaire et modélisation nucléaire : sondes de chiralite de l'ADN, modèles d'AP-endonuclease." Université Joseph Fourier (Grenoble ; 1971-2015), 1996. http://www.theses.fr/1996GRE10079.

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Les avancees considerables realisees dans le domaine de la synthese de fragments d'adn et des methodes d'analyse de structures, notamment en resonance magnetique nucleaire (rmn) et en modelisation moleculaire, ont permis d'ameliorer nos connaissances des interactions adn-ligand. Notre travail s'inscrit dans cette problematique. Nous avons plus particulierement etudie deux classes de molecules qui ont respectivement des applications potentielles comme (1) sondes de chiralite de l'adn ou comme (2) nucleases artificielles interagissant specifiquement au niveau des lesions abasiques (ap-lyases). A
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Burya, Scott J. "The Photochemistry and DNA Binding of Dirhodium Complexes." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366294878.

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Books on the topic "DNA intercalating ligand"

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Aldrich-Wright, Janice. Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules. Springer-Verlag/Wien, 2011.

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Aldrich-Wright, Janice. Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules. Springer, 2011.

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Aldrich-Wright, Janice. Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules. Springer, 2014.

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Book chapters on the topic "DNA intercalating ligand"

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Hélène, Claude. "Specific Gene Regulation by Oligodeoxynucleotides Covalently Linked to Intercalating Agents." In DNA—Ligand Interactions. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5383-6_8.

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Miroshnychenko, Kateryna V., and Anna V. Shestopalova. "Molecular Docking of Biologically Active Substances to Double Helical Nucleic Acids." In Advances in Medical Technologies and Clinical Practice. IGI Global, 2016. http://dx.doi.org/10.4018/978-1-5225-0362-0.ch005.

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Molecular docking of ligands to DNA-targets is of great importance for the design of new anticancer drugs. Unfortunately, most docking programs were developed for protein-ligand docking which raises a question about their applicability for the DNA-ligand docking. In this study, the popular docking programs AutoDock Vina, AutoDock4 and AutoDock3 were compared for a test set of 50 DNA-ligand complexes taken from the Nucleic Acid Database. It was shown that the version 3.05 of the AutoDock program was the most successful in reproducing the structures of intercalation and minor-groove complexes. T
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Ihmels, Heiko, and Laura Thomas. "Intercalation of Organic Ligands as a Tool to Modify the Properties of DNA." In Materials Science of DNA. CRC Press, 2011. http://dx.doi.org/10.1201/b11290-4.

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"Intercalation of Organic Ligands as a Tool to Modify the Properties of DNA." In Materials Science of DNA. CRC Press, 2016. http://dx.doi.org/10.1201/b11290-7.

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