Academic literature on the topic 'DNA intercalators'

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Journal articles on the topic "DNA intercalators"

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Sugawara, Yuuki, Takanori Tamaki, and Takeo Yamaguchi. "DNA molecular recognition of intercalators affects aggregation of a thermoresponsive polymer." Polym. Chem. 5, no. 16 (2014): 4612–16. http://dx.doi.org/10.1039/c4py00600c.

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Wilson, W. David. "ChemInform Abstract: DNA Intercalators." ChemInform 32, no. 5 (2001): no. http://dx.doi.org/10.1002/chin.200105275.

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Gilad, Yocheved, and Hanoch Senderowitz. "Docking Studies on DNA Intercalators." Journal of Chemical Information and Modeling 54, no. 1 (2013): 96–107. http://dx.doi.org/10.1021/ci400352t.

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Liu, Hong-Ke, and Peter J. Sadler. "Metal Complexes as DNA Intercalators." Accounts of Chemical Research 44, no. 5 (2011): 349–59. http://dx.doi.org/10.1021/ar100140e.

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Cory, Michael, TerriA Fairley, StevenC Zimmerman, and CarolR Lamberson. "Studies on polyfunctional DNA intercalators." Journal of Molecular Graphics 7, no. 3 (1989): 173–74. http://dx.doi.org/10.1016/0263-7855(89)80030-x.

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Takagi, Makoto. "Threading intercalation to double-stranded DNA and the application to DNA sensing. Electrochemical array technique." Pure and Applied Chemistry 73, no. 10 (2001): 1573–77. http://dx.doi.org/10.1351/pac200173101573.

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Electrochemical labeling of double-stranded (ds) DNA is achieved by redox-active DNA intercalators. Threading intercalators derived from naphthalenediimide appended with ferrocene reporter group in the side arms are particularly useful for this purpose. This allows a sensitive electrochemical detection of DNA hybridization on an array, providing a great potential for low-cost, high-throughput, and quick DNA screening technique in post-genome study.
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Wink, Michael. "Potential of DNA Intercalating Alkaloids and Other Plant Secondary Metabolites against SARS-CoV-2 Causing COVID-19." Diversity 12, no. 5 (2020): 175. http://dx.doi.org/10.3390/d12050175.

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Many plants produce secondary metabolites (PSMs) with antiviral activities. Among the antiviral PSMs, lipophilic terpenoids in essential oils can disturb the lipid envelope of viruses. Phenols and polyphenols (flavonoids, rosmarinic acid and tannins) attack viral proteins present in the viral membrane or inside the virus particle. Both phenolics and essential oils are active against free viral particles but not—or to a lesser degree—after a virus has entered a host cell. Another group of PSMs is directed against DNA or RNA. These are DNA intercalators such as sanguinarine, berberine, emetine a
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Terbrueggen, Robert H., Timothy W. Johann, and Jacqueline K. Barton. "Functionalized Rhodium Intercalators for DNA Recognition." Inorganic Chemistry 37, no. 26 (1998): 6874–83. http://dx.doi.org/10.1021/ic980837j.

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Shade, Chad M., Robert D. Kennedy, Jessica L. Rouge, et al. "Duplex-Selective Ruthenium-Based DNA Intercalators." Chemistry - A European Journal 21, no. 31 (2015): 10983–87. http://dx.doi.org/10.1002/chem.201502095.

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Viglasky, Viktor, and Patrik Danko. "Intercalators: Contra cruciform extrusion in DNA." Analytical Biochemistry 360, no. 1 (2007): 7–13. http://dx.doi.org/10.1016/j.ab.2006.10.023.

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Dissertations / Theses on the topic "DNA intercalators"

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Paradis, Michel 1976. "The design and synthessis of platinum-based DNA intercalators /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31523.

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Over the past years, considerable attention has focused on the synthesis of small complexes that can bind and react at specific DNA sequences. This understanding of how to target DNA sites with specificity becomes important for nucleotide probing and novel chemotherapeutics.<br>Inert and stable transition-metal complexes are already being used for this purpose. Square planar platinum (II) complexes containing an aromatic heterocyclic ligand can insert and stack between the double helix base pairs. Two known ligands, DPPZ and phi, do intercalate DNA when chelating ruthenium, rhodium, or osmium.
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Maehigashi, Tatsuya. "Ultra-high resolution DNA crystallography." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29684.

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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Williams, Loren; Committee Member: Bottomley, Lawrence; Committee Member: Hud, Nicholas; Committee Member: Oyelere, Adegboyega; Committee Member: Wartell, Roger. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Derrat, Hanan S. "Organic and metal organic cationic DNA intercalators based on DPPZ analogues." Thesis, University of Sheffield, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574605.

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New metal complex derivatives of tppz containing cationic "diquat" sites have been synthesized and characterized. Their interaction with DNA has also been explored .. Water-soluble organic cationic derivatives of the dppz ligand with a variety of functional groups and number of aromatic rings in the phenazine region have also been synthesised and characterized. These systems were synthesized with the aim of modulating the energy of the internal charge transfer excited state of the parent cation. The interactions of the new organic diquaterary salts of dppz with ON A have been studied. Metal co
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Sprague, Robin M. "Molecular modeling of DNA with minor groove binding agents and intercalators." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/539.

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The molecular modeling of several drugs in complexes with deoxyribonucleic acid (DNA) was undet1aken. Selected bis-lexitropsins, based upon NMR and modeling studies of bis-distamycin A, were modeled with an oligonucleotide d(CGAACA TGTTCG)2 using MidasPlus and AMBER 4.0. Intercalators ethidium, ellipticinc. mitoxantrone, and bisantrene were modeled with an oligonucleotide d(CGCG)~ using SpartanPlus and DOCK 4.0. The binding site was prepared from an x-ray study of this oligonucleotide interacting with ditercalinium, a bis-intercalator. The purpost: of this study was to estimate the conformatio
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Deeyaa, Blessing D. "DNA Photocleavage by 9-Aminomethylanthracene Dyes at pH 7.0: Ionic Strength Effects." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_theses/39.

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DNA photosensitizers are compounds that are capable of binding in to DNA strands through groove binding, intercalation, or electrostatic interactions. Excitation of these agents by light generates reactive oxygen species which causes extensive photo-oxidative damage to genomic DNA. Physiological concentrations of NaCl and KCl are ~ 150 mM and 260 mM within the cell nucleus where DNA is contained. Unfortunately, the ability of most photosensitizers to bind to double-helical DNA is reduced and photocleavage yields are diminished as concentrations of salt increase. The aim of this project is t
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Fagenson, Alexander. "Gold (iii) macrocycles are dna intercalators that inhibit topoisomerase i and ii." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1536.

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Human Topoisomerase IB (TOP1) and Topoisomerase II? (TOP2?) are essential nuclear enzymes that control DNA topology during DNA replication, gene transcription and cell division. These enzymes carry out their catalytic function by making transient single-strand (type I) or double-strand (type II) breaks in the DNA. In vivo, these complexes are short-lived but can be exploited by anti-cancer drugs to mechanistically kill cancer cells. Two general classes of compounds can kill cancer cells through a topo-targeted mechanism. Interfacial Poisons (IFPs) act at the enzyme-DNA interface to inhibit the
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Liu, Tao Lewis Nathan Saul Barton Jacqueline K. "Electrochemical studies of electron transfer in DNA films with covalently tethered intercalators /." Diss., Pasadena, Calif. : California Institute of Technology, 2007. http://resolver.caltech.edu/CaltechETD:etd-08312006-131856.

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Rai, Saroj. "Viral inactivation using DNA intercalators and dyes for sterilization of blood products /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487779120908841.

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Sprague, Robin M. "Molecular modeling of DNA with minor groove binding agents and intercalators : a thesis." Scholarly Commons, 2001. https://scholarlycommons.pacific.edu/uop_etds/539.

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The molecular modeling of several drugs in complexes with deoxyribonucleic acid (DNA) was undet1aken. Selected bis-lexitropsins, based upon NMR and modeling studies of bis-distamycin A, were modeled with an oligonucleotide d(CGAACA TGTTCG)2 using MidasPlus and AMBER 4.0. Intercalators ethidium, ellipticinc. mitoxantrone, and bisantrene were modeled with an oligonucleotide d(CGCG)~ using SpartanPlus and DOCK 4.0. The binding site was prepared from an x-ray study of this oligonucleotide interacting with ditercalinium, a bis-intercalator. The purpost: of this study was to estimate the conformatio
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Teixeira, Susana Christina Marujo. "Crystallographic studies on a thermophile Xylanase and structural studies on anti-cancer DNA intercalators." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501318.

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This thesis describes structural studies on a Xylanase and on DNA intercalators with anticancer properties. The first chapter introduces the molecules under study while in the second chapter the methodology is described. The third chapter describes an anisotropic refinement of the structure of Thermoascus aurantiacus Xylanase I. This glycosyl hydrolase has been studied for it has promising practical applications and its specificity and mechanism of action are not yet fully understood. The important factors lie in structural details, some of which were revealed by the model refined to 1.14A res
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Books on the topic "DNA intercalators"

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Martin, Patrick N. Design, synthesis, kinetics and biological evaluation of acridine baseed DNA intercalators. University College Dublin, 1996.

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Book chapters on the topic "DNA intercalators"

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Navarro, Maribel, Gonzalo Visbal, and Edgar Marchán. "DNA Metallo-Intercalators with Leishmanicidal Activity." In Programmed Cell Death in Protozoa. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-76717-8_6.

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Neidle, Stephen. "Computer-Aided Design of New DNA Intercalators." In Mechanisms of DNA Damage and Repair. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4615-9462-8_26.

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Ikeda, T., T. Takahashi, M. Mori, et al. "Chemically Switched DNA Intercalators Using Modified Cyclodextrin Complexes." In Proceedings of the Eighth International Symposium on Cyclodextrins. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_50.

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Lambert, Bernard, Evelyne Segal-Bendirdjian, Bernard P. Roques, and Jean-Bernard Le Pecq. "Induction of Futile DNA Repair Processes by Bifunctional Intercalators." In DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-1327-4_51.

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Sip, M., and M. Leng. "DNA, cis-Platinum and Intercalators: Catalytic Activity of the DNA Double Helix." In Nucleic Acids and Molecular Biology. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77950-3_1.

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Tavassoli, Manoochehr, and Sydney Shall. "Effect of DNA Intercalators on Poly(ADP-Ribose) Glycohydrolase Activity." In Proceedings in Life Sciences. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70589-2_21.

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Ikeda, T., A. Nakazato, M. Mori, A. Ueno, F. Toda, and H. J. Schneider. "Conformational Studies on Anthryl(Alkylamino)-β-Cyclodextrin Complexes and Their Abilities as DNA Intercalators." In Molecular Recognition and Inclusion. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5288-4_62.

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Smith, Amy Rhoden, and Brent Iverson. "Chapter 2. NDI as a DNA Intercalator." In Monographs in Supramolecular Chemistry. Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/9781782621386-00037.

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Bailly, Christian, and Jean-Pierre Hénichart. "Molecular Pharmacology of Intercalator-Groove Binder Hybrid Molecules." In Molecular Aspects of Anticancer Drug-DNA Interactions. Macmillan Education UK, 1994. http://dx.doi.org/10.1007/978-1-349-13330-7_4.

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Jing-de, Zhu, Sun Xiao-ping, and Wang Fan. "Effects of a DNA Intercalator, Ethidium Bromide on Chromatin Structure of Chicken Erythrocyte." In Nuclear Structure and Function. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0667-2_58.

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Conference papers on the topic "DNA intercalators"

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Backer, Adam S., Andreas S. Biebricher, Graeme A. King, Iddo Heller, Gijs J. L. Wuite, and Erwin J. G. Peterman. "DNA intercalators tilt, wobble, and twirl: elucidating DNA overstretching (Conference Presentation)." In Single Molecule Spectroscopy and Superresolution Imaging XII, edited by Ingo Gregor, Zygmunt K. Gryczynski, and Felix Koberling. SPIE, 2019. http://dx.doi.org/10.1117/12.2507066.

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Schurr, J. M., Pengguang Wu, and Bryant S. Fujimoto. "Dynamics of DNA/intercalator complexes." In OE/LASE '90, 14-19 Jan., Los Angeles, CA, edited by Joseph R. Lakowicz. SPIE, 1990. http://dx.doi.org/10.1117/12.17702.

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Sakata, Toshiya, Hidenori Otsuka, and Yuji Miyahara. "Detection of DNA Molecules Using Insulated Gate Field Effect Transistor and Intercalator." In 2003 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2003. http://dx.doi.org/10.7567/ssdm.2003.f-5-3.

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Lin, Clement, Raveendra I. Mathad, Neil Sidell, and Danzhou Yang. "Abstract 2445: DNA recognition by XR5944, a novel bis-intercalator and potent anticancer drug." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2445.

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Halid, Nurul Izni Abdullah, Siti Aishah Hasbullah, Haslina Ahmad, Lee Yook Heng, Nurul Huda Abd Karim, and Siti Norain Harun. "Electrochemical DNA biosensor for detection of porcine oligonucleotides using ruthenium(II) complex as intercalator label redox." In THE 2014 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2014 Postgraduate Colloquium. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4895214.

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Senderovich, Shai, David Jones, Alfred Ajami, and Fiona McLaughlin. "Abstract 3665: The novel DNA intercalator amonafide (AS1413), disrupts the cell cycle by mechanisms distinct from those of Topo II inhibitors daunorubicin and etoposide." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3665.

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