Relevant bibliographies by topics / DNA-LEE Interactions

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  2. Dissertations / Theses

Academic literature on the topic 'DNA-LEE Interactions'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "DNA-LEE Interactions"

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Morgan, Jason K., Ronan K. Carroll, Carly M. Harro, Khoury W. Vendura, Lindsey N. Shaw, and James T. Riordan. "Global Regulator of Virulence A (GrvA) Coordinates Expression of Discrete Pathogenic Mechanisms in Enterohemorrhagic Escherichia coli through Interactions with GadW-GadE." Journal of Bacteriology 198, no. 3 (2015): 394–409. http://dx.doi.org/10.1128/jb.00556-15.

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ABSTRACTGlobal regulator of virulence A (GrvA) is a ToxR-family transcriptional regulator that activates locus of enterocyte effacement (LEE)-dependent adherence in enterohemorrhagicEscherichia coli(EHEC). LEE activation by GrvA requires the Rcs phosphorelay response regulator RcsB and is sensitive to physiologically relevant concentrations of bicarbonate, a known stimulant of virulence systems in intestinal pathogens. This study determines the genomic scale of GrvA-dependent regulation and uncovers details of the molecular mechanism underlying GrvA-dependent regulation of pathogenic mechanism
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Lee, Benhur. "Diversity, pathogenicity and pandemic potential of Henipavirus: an interview with Benhur Lee." Future Virology 14, no. 7 (2019): 449–51. http://dx.doi.org/10.2217/fvl-2019-0065.

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Biography Dr Benhur Lee is a Professor of Microbiology at the Icahn School of Medicine at Mount Sinai (ISMMS, NY, USA). He obtained his MD from Yale University School of Medicine (1995) and completed his clinical/postdoctoral training at the University of Pennsylvania (1995–2001). He was a Professor in the Department of Microbiology, Immunology & Molecular Genetics at the David Geffen School of Medicine at UCLA (2001–2013). Dr Lee is an appointed member of the NIH Novel and Exceptional Technology and Research Advisory Committee (NExTRAC), formerly known as the recombinant DNA Advisory comm
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Haack, Kenneth R., Christopher L. Robinson, Kristie J. Miller, Jonathan W. Fowlkes, and Jay L. Mellies. "Interaction of Ler at the LEE5 (tir) Operon of Enteropathogenic Escherichia coli." Infection and Immunity 71, no. 1 (2003): 384–92. http://dx.doi.org/10.1128/iai.71.1.384-392.2003.

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ABSTRACT The genome of enteropathogenic Escherichia coli (EPEC) encodes a global regulator, Ler (locus of enterocyte effacement [LEE]-encoded regulator), which activates expression of several polycistronic operons within the 35.6-kb LEE pathogenicity island, including the LEE2-LEE3 divergent operon pair containing overlapping −10 regions and the LEE5 (tir) operon. Ler is a predicted 15-kDa protein that exhibits amino acid similarity with the nucleoid protein H-NS. In order to study Ler-mediated activation of virulence operons in EPEC, we used a molecular approach to characterize the interactio
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El Gaafary, Menna, Tatiana Syrovets, Hany M. Mohamed, et al. "Synthesis, Cytotoxic Activity, Crystal Structure, DFT Studies and Molecular Docking of 3-Amino-1-(2,5-dichlorophenyl)-8-methoxy-1H-benzo[f]chromene-2-carbonitrile." Crystals 11, no. 2 (2021): 184. http://dx.doi.org/10.3390/cryst11020184.

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The target compound 3-amino-1-(2,5-d ichlorophenyl)-8-methoxy-1H-benzo[f]-chromene-2-carbonitrile (4) was synthesized via a reaction of 6-methoxynaphthalen-2-ol (1), 2,5-dichlorobenzaldehyde (2), and malononitrile (3) in ethanolic piperidine solution under microwave irradiation. The newly synthesized β-enaminonitrile was characterized by FT-IR, 1H NMR, 13C NMR, mass spectroscopy, elemental analysis and X-ray diffraction data. Its cytotoxic activity was evaluated against three different human cancer cell lines MDA-MB-231, A549, and MIA PaCa-2 in comparison to the positive controls etoposide and
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Abdullahi, Mustapha, and Shola Elijah Adeniji. "In-silico Molecular Docking and ADME/Pharmacokinetic Prediction Studies of Some Novel Carboxamide Derivatives as Anti-tubercular Agents." Chemistry Africa 3, no. 4 (2020): 989–1000. http://dx.doi.org/10.1007/s42250-020-00162-3.

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AbstractMolecular docking simulation of thirty-five (35) molecules of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide (IPA) with Mycobacterium tuberculosis target (DNA gyrase) was carried out so as to evaluate their theoretical binding affinities. The chemical structure of the molecules was accurately drawn using ChemDraw Ultra software, then optimized at density functional theory (DFT) using Becke’s three-parameter Lee–Yang–Parr hybrid functional (B3LYP/6-311**) basis set in a vacuum of Spartan 14 software. Subsequently, the docking operation was carried out using PyRx virtual screeni
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Sivak, Jeremy M., Judith A. West-Mays, Amy Yee, Trevor Williams та M. Elizabeth Fini. "Transcription Factors Pax6 and AP-2α Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B". Molecular and Cellular Biology 24, № 1 (2004): 245–57. http://dx.doi.org/10.1128/mcb.24.1.245-257.2004.

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ABSTRACT Pax6 is a paired box containing transcription factor that resides at the top of a genetic hierarchy controlling eye development. It continues to be expressed in tissues of the adult eye, but its role in this capacity is unclear. Pax6 is present in the adult corneal epithelium, and we showed that the amount of Pax6 is increased at the migrating front as the epithelium resurfaces the cornea after injury (J. M. Sivak, R. Mohan, W. B. Rinehart, P. X. Xu, R. L. Maas, and M. E. Fini, Dev. Biol. 222:41-54, 2000). We also showed that Pax6 controls activity of the transcriptional promoter for
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ALFONSO-JAUME, Maria Alejandra, Rajeev MAHIMKAR, and David H. LOVETT. "Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells." Biochemical Journal 380, no. 3 (2004): 735–47. http://dx.doi.org/10.1042/bj20031281.

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The transition of normally quiescent glomerular MCs (mesangial cells) to a highly proliferative phenotype with characteristics of myofibroblasts is a process commonly observed in inflammatory diseases affecting the renal glomerulus, the ultimate result of which is glomerulosclerosis. Generation of proteolytically active MMP (matrix metalloproteinase)-2 by the membrane-associated membrane type 1 (MT1)-MMP is responsible for the transition of mesangial cells to the myofibroblast phenotype [Turck, Pollock, Lee, Marti and Lovett (1996) J. Biol. Chem. 271, 15074–15083]. In the present study, we sho
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Jiménez, Rafael, Sara B. Cruz-Migoni, Alejandro Huerta-Saquero, Víctor H. Bustamante, and José L. Puente. "Molecular Characterization of GrlA, a Specific Positive Regulator of ler Expression in Enteropathogenic Escherichia coli." Journal of Bacteriology 192, no. 18 (2010): 4627–42. http://dx.doi.org/10.1128/jb.00307-10.

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ABSTRACT Enteropathogenic Escherichia coli (EPEC) infections are characterized by the formation of attaching and effacing (A/E) lesions on the surfaces of infected epithelial cells. The genes required for the formation of A/E lesions are located within the locus of enterocyte effacement (LEE). Ler is the key regulatory factor controlling the expression of LEE genes. Expression of the ler gene is positively regulated by GrlA, which is encoded by the LEE. Here, we analyze the mechanism by which GrlA positively regulates ler expression and show that in the absence of H-NS, GrlA is no longer essen
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Abdelrehim, El-sayed M., and Doaa S. El-Sayed. "A New Synthesis of Poly Heterocyclic Compounds Containing [1,2,4]triazolo and [1,2,3,4]tetrazolo Moieties and their DFT Study as Expected Anti-cancer Reagents." Current Organic Synthesis 17, no. 3 (2020): 211–23. http://dx.doi.org/10.2174/1570179417666200226092516.

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Background: 2-amino-3-cyanopyridines are good starting reagents that have been used in synthesis of many heterocyclic compounds such as pyridopyrimidines, [1,2,4]triazolo and [1,2,3,4] tetrazolo derivatives which have biological activities as anti-microbial and cytotoxic activities. Meanwhile [1,2,4]triazolo and [1,2,3,4]tetrazolo derivatives are well known to possess many physiological activities, such as anticancer , antifungal, muscle relaxant, hypnotic, anti-inflammatory, diuretic and antihypertensive activities. A broad class of heterocyclic compounds has been studied to demonstrate their
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Ke, Weizhong, Dianfeng Zhou, Jianzhong Wu, and Kang Ji. "Surface-Enhanced Raman Spectra of Calf Thymus DNA Adsorbed on Concentrated Silver Colloid." Applied Spectroscopy 59, no. 4 (2005): 418–23. http://dx.doi.org/10.1366/0003702053641487.

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Raman and surface-enhanced Raman scattering (SERS) spectra of calf thymus DNA were investigated. We have carried out improvements to the silver colloid preparation method of Lee and Meisel in two respects. In one method, the silver sol was boiled with rapid stirring for over two hours. In the second method, the silver sol was concentrated by centrifugation before adding it to the DNA solution. The resulting hydrosol could be stored for 15 months because of its high stabilization. Structural information with respect to the phosphate backbone, deoxyribose, and four bases of DNA could be obtained
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Dissertations / Theses on the topic "DNA-LEE Interactions"

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Abdallah, Buthina A. "Independent Generation and Investigation of the C3'-deoxy-3'-thymidinyl Radical: A Proposed Intermediate in DNA-LEE Interactions." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1321646592.

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