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Dissertations / Theses on the topic 'DNA nanotechnology'

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1

Benn, Florence. "Functional DNA nanotechnology." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1ed7a9d7-acf2-46ee-97d1-b28084b3d4cc.

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This thesis sets out to further the field of functional DNA nanotechnology through the design of novel functional DNA scaffolds, and investigates their applications and efficacy. The work presented here comprises two parts: The design of a chiral DNA nanotube that acts as a scaffold for motor motion and for an enzyme cascade; and the design of two different tetrahedral scaffolds for selection of a combination of three ligands, which together have a greater binding effect than the sum of the individual components. It begins by proposing the design of a DNA origami nanotube which distinguishes b
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2

Pechstedt, Katrin. "A nanotechnology approach to DNA analysis." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/340250/.

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This thesis describes the investigation of quantum dots and nano-structured metallic films for use in single genomic DNA analysis. The fluorescence of continuously illuminated core/shell CdSe/ZnS quantum dots (QDs) under various atmospheric conditions is investigated experimentally. Initial enhancement in fluorescence intensity is observed followed by degradation; both are highly dependent on the atmospheric conditions. Following a series of studies theories are put forward to explain these observations. Solution mixtures of DNA strands and QDs are imaged with Atomic Force Microscopy and Fluor
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Dannenberg, Frits Gerrit Willem. "Modelling and verification for DNA nanotechnology." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a0b5343b-dcee-44ff-964b-bdf5a6f8a819.

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DNA nanotechnology is a rapidly developing field that creates nanoscale devices from DNA, which enables novel interfaces with biological material. Their therapeutic use is envisioned and applications in other areas of basic science have already been found. These devices function at physiological conditions and, owing to their molecular scale, are subject to thermal fluctuations during both preparation and operation of the device. Troubleshooting a failed device is often difficult and we develop models to characterise two separate devices: DNA walkers and DNA origami. Our framework is that of c
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4

Ishihara, Yoshihiro. "DNA-inspired materials for 'bottom-up' nanotechnology." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112640.

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DNA is a remarkable material that is both an inspiration for polymer nanotechnology and a versatile building block for assembling well-defined nanostructures. To create polymeric materials that would be useful in nanotechnology, we synthesized block copolymers containing thymine and diamidopyridine side chains. These DNA-mimetic polymers self-assembled into spherical aggregates in solution, held together by hydrogen bonding interactions. We have reported the first example of a block copolymer micellar aggregate that is capable of selective recognition of small-molecule guests, with concomitant
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5

Goodman, Brian Kruzick. "Investigating Cytoskeletal Motor Mechanisms using DNA Nanotechnology." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11222.

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The microtubule cytoskeleton plays a vital role in the spatial-temporal organization of subcellular cargo required to maintain homeostasis and direct cell division. Cytoplasmic dynein and kinesin are opposite-polarity, microtubule-based motors that transport a wide variety of cargo throughout eukaryotic cells. While much is known about the stepping mechanism of kinesin from decades of study, cytoplasmic dynein's size and complexity has limited our understanding of its underlying motor mechanism. Here, a minimal, artificially-dimerized dynein motor was observed with two-color, near-simultane
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6

Šlikas, Justinas. "Assembly and operation of a single stranded DNA catenane." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25796.

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The creation of molecular machines has been one of the goals of modern nanotechnology for a few decades. Such machines can be assembled from small molecules, as well as DNA. Of particular interest are mechanically interlocked nanoconstructs – catenanes and rotaxanes. These structures offer developments such as nanoswitches and rotational motors. DNA nanotechnology has produced numerous systems that consist of catenanes that could perform programmable switching and stimuli-responsive behaviour, as well as switching between stations in a semi-autonomous, rotary, motor-like behaviour. Energy tran
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7

Cheng, Jie. "Achieving new developments in DNA nanotechnology by means of DNA self-assembly /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CENG%202008%20CHENG.

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8

Kopatsch, Jens. "New motifs in DNA nanotechnology and their applications." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972379592.

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9

Nguyen, ThaoNguyen. "Porphyrin-DNA as scaffold for nanoarchitecture and nanotechnology." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/193139/.

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Porphyrins, a substance class that can be found in diverse materials including green leaves and red blood cells, have been studied extensively over many years due to their potential industrial applications, e.g. in making optical electronic devices, in artificial photosynthesis or in sensors. In contrast, DNA has only recently been found to be a good scaffold for the construction of functional molecules. Combining the chemical properties of porphyrins and DNA could open the door to the production of multiporphyrin arrays using DNA as a scaffold; such materials could have multiple applications,
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10

Briggs, Emily N. "Scaffolded DNA Origami Nanotechnology for Receptor Ligand Studies." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374169534.

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11

Wei, Diming. "The beauty of DNA architecture : the design and applications in DNA nanotechnology /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?CBME%202009%20WEI.

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12

Aldaye, Faisal A. 1979. "Supramolecular DNA nanotechnology : discrete nanoparticle organization, three-dimensional DNA construction, and molecule templated DNA assembly." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115668.

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The field of structural DNA nanotechnology utilizes DNA's powerful base-pairing molecular recognition criteria to help solve real challenges facing researchers in material science and nanotechnology, some of which include synthesis, sensing, catalysis, delivery, storage, optics, electronics, and scaffolding. In it, DNA is stripped away from any of its preconceived biological roles, and is treated as a powerful synthetic polymer. A subarea of research that our group has recently termed supramolecular DNA nanotechnology is emerging, and is proving to be a powerful complement to some of the alrea
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13

Nutiu, Razvan Li Yingfu. "Fluorescent functional DNA for bioanalysis, drug discovery and nanotechnology." *McMaster only, 2006.

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14

Huang, Da. "DNA nanotechnology and nanopatterning : biochips for single-molecule investigations." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/31799.

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The controlled organization of individual molecules and nanostructures with nanoscale accuracy is of great importance in the investigation of single-molecule events in biological and chemical assays, as well as for the fabrication of the next generation optoelectronic devices. In this regard, the precise patterning of individual molecules into hierarchical structures has attracted substantial research interest in recent years. DNA has been shown to be an ideal structural material for this purpose, due to the specificity of its programmability and outstanding chemical flexibility. DNA origami c
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15

Cail, Peter James. "DNA nanotechnology and supramolecular chemistry in biomedical therapy applications." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8424/.

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The overall aim of this thesis is to investigate the combination of supramolecular cylinders with DNA nanotechnology and assess any effects that can occur through binding and any applications this could have in biomedical therapy applications. From this base it is hoped that insight can be gained as to whether supramolecular chemistry can be used to create DNA nano-machines, capable of triggered release of cargo. The thesis begins with a review of DNA discovery, structure and binding by small molecules, followed by a review of the field of DNA nanotechnology. By expanding on the field of DNA n
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16

Kanatani, Keiichiro. "Artificial control of protein biosynthetic machinery and DNA nanotechnology." 京都大学 (Kyoto University), 2006. http://hdl.handle.net/2433/143989.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第12292号<br>工博第2621号<br>新制||工||1370(附属図書館)<br>24128<br>UT51-2006-J285<br>京都大学大学院工学研究科合成・生物化学専攻<br>(主査)教授 青山 安宏, 教授 木村 俊作, 教授 濵地 格<br>学位規則第4条第1項該当
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17

Huhle, Alexander. "Selbstassemblierende DNA-Netzwerke." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1237543784090-08609.

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DNA-Netzwerke können als formgebende Muster (Template) zur Funktionalisierung technischer Oberflächen für die bottom-up Materialsynthese Verwendung finden. Zum Aufbau solcher Netzwerke werden synthetisch hergestellte DNA-Oligonukleotide hybridisiert. Im ersten Teil der Arbeit wird ein Weg beschrieben, wie die zum gezielten Aufbau einer vorgegebenen Struktur notwendigen DNA-Oligonukleotide hergeleitet werden können. Dies geschieht über eine schrittweise Zerlegung der Struktur in Bausteine, welche wiederum in die Oligonukleotide zerlegt werden. Weiterhin werden verschiedene DNA-Strukturen und Ne
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18

Ouldridge, Thomas E. "Coarse-grained modelling of DNA and DNA self-assembly." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b2415bb2-7975-4f59-b5e2-8c022b4a3719.

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In this thesis I present a novel coarse-grained model of deoxyribonucleic acid (DNA). The model represents single-stranded DNA as a chain of rigid nucleotides, and includes potentials to represent chain connectivity, excluded volume, hydrogen-bonding and base stacking interactions. The parameterization of these interactions is justified by comparing the model's representation of a range of physical phenomena to experimental data. In particular, the geometrical structure and elastic moduli of duplex DNA, and the flexibility of single-stranded DNA, are shown to be physically reasonable. Addition
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19

Adendorff, Matthew Ralph. "A computational study of DNA four-way junctions and their significance to DNA nanotechnology." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103647.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2016.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 161-180).<br>The field of DNA nanotechnology has rapidly evolved over the past three decades, reaching a point where researchers can conceive of and implement both bioinspired and biomimetic devices using the programmed self-assembly of DNA molec
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20

Hudoba, Michael W. "Force Sensing Applications of DNA Origami Nanodevices." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471474143.

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21

Morgan, Michael Andrew. "DNA-protein nanotechnology developing unique biological nanostructures and biological tools /." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2639.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.<br>Thesis research directed by: Biochemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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22

Sandén, Camilla. "Nanostructures on a Vector : Enzymatic Oligo Production for DNA Nanotechnology." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85985.

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The technique of DNA origami utilizes the specific and limited bonding properties of DNA to fold single stranded DNA sequences of various lengths to form a predesigned structure. One longer sequence is used as a scaffold and numerous shorter sequences called staples, which are all complementary to the scaffold sequence, are used to fold the scaffold into intricate shapes. The most commonly used scaffold is derived by extracting the genome of the M13 phage and the staples are usually chemically synthesized oligonucleotides. Longer single stranded sequences are difficult to synthesize with high
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23

FENG, YIHONG. "Controllable cell delivery and chromatin structure observation using DNA nanotechnology." Kyoto University, 2020. http://hdl.handle.net/2433/258987.

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24

Dai, Mingjie. "Nanoscale Organization and Optical Observation of Biomolecules With DNA Nanotechnology." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493324.

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Understanding biomolecular information at the single-molecule level requires tools for manipulating and observing individual biomolecules at the nanoscale. Programmable DNA nanotechnology provides an ideal interface to bridge engineering principles with biomolecular compatibility, especially with high-information-content, programmable molecular interactions. In my dissertation research, I have focused on two specific topics that both harness the programmable and high-information-content nature of complementary DNA interactions, to arrange and observe biomolecules at the single-molecule level,
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25

CORAL, LUCIA. "HIGH-RESOLUTION NUCLEIC ACID ANALYSIS WITH A DNA NANOTECHNOLOGY APPROACH." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908115.

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The goal of my research program is to develop a DNA-based nanosensor for nucleic acids analysis. I plan to use DNA Origami nanostructures that are formed by a-few-thousand-nucleotides-long, circular, single stranded (ss)DNA “scaffold” folded to form a specific shape by the action of a few hundreds of short (approx. 30 nucleotides) ssDNA “staples”, which hybridize over non-consecutive regions of the scaffold. Staples can be incorporated within the structure with well-defined stoichiometry and some of them can be designed to serve as highly-specific receptor for short nucleic acids sequences. I
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26

Sadowski, John Paul. "Design and synthesis of dynamically assembling DNA nanostructures." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11272.

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Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of base pairing, sophisticated spatial and temporal control have both been demonstrated in DNA self-assembly, but largely as separate pursuits. This dissertation extends a new approach, called developmental self-assembly, that integrates temporal with spatial control by using a prescriptive molecular pr
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27

Huhle, Alexander. "Selbstassemblierende DNA-Netzwerke." Doctoral thesis, Technische Universität Dresden, 2008. https://tud.qucosa.de/id/qucosa%3A23842.

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DNA-Netzwerke können als formgebende Muster (Template) zur Funktionalisierung technischer Oberflächen für die bottom-up Materialsynthese Verwendung finden. Zum Aufbau solcher Netzwerke werden synthetisch hergestellte DNA-Oligonukleotide hybridisiert. Im ersten Teil der Arbeit wird ein Weg beschrieben, wie die zum gezielten Aufbau einer vorgegebenen Struktur notwendigen DNA-Oligonukleotide hergeleitet werden können. Dies geschieht über eine schrittweise Zerlegung der Struktur in Bausteine, welche wiederum in die Oligonukleotide zerlegt werden. Weiterhin werden verschiedene DNA-Strukturen und Ne
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28

Hartzell, Brittany M. "DNA manipulation and characterization for nanoscale electronics." Ohio : Ohio University, 2004. http://www.ohiolink.edu/etd/view.cgi?ohiou1108051644.

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29

Huang, Chao-Min. "Robust Design Framework for Automating Multi-component DNA Origami Structures with Experimental and MD coarse-grained Model Validation." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu159051496861178.

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30

Hinkle, Kevin R. "Study of DNA Combing and Imprinting Automation and Microwell-Nanochannel Electrophoresis." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313675665.

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31

Derr, Nathan Dickson. "Coordination of Individual and Ensemble Cytoskeletal Motors Studied Using Tools from DNA Nanotechnology." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10889.

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The cytoskeletal molecular motors kinesin-1 and cytoplasmic dynein drive many diverse functions within eukaryotic cells. They are responsible for numerous spatially and temporally dependent intracellular processes crucial for cellular activity, including cytokinesis, maintenance of sub-cellular organization and the transport of myriad cargos along microtubule tracks. Cytoplasmic dynein and kinesin-1 are processive, but opposite polarity, homodimeric motors; they each can take hundreds of thousands of consecutive steps, but do so in opposite directions along their microtubule tracks. These step
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32

Zhu, Jinhao. "Uniquimer 3D, a software system for structural DNA nanotechnology design, analysis and evaluation /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CSED%202008%20ZHU.

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33

Brady, Ryan. "Crystalline frameworks self-assembled from amphiphilic DNA nanostructures." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289706.

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Many emerging technologies would greatly benefit from reliable methods for the production of functional materials with well-defined 3D nanoscale structure. Conceptually, approaches to produce such architectures are divided into two broad classes; top down and bottom up manufacture. In the top down approach, nanoscale structure is created through the controlled removal of material from a bulk starting object. Top down methods have a proven record of reliability in the fabrication of extended two dimensional arrays with fine control over nanoscale features. However, such approaches become increa
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34

Daljit, Singh Jasleen Kaur. "Lipid-interacting switchable DNA origami nanostructures." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28197.

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DNA nanotechnology allows for the programmable self-assembly of nanostructures of arbitrary shapes and sizes. DNA nanostructures can be hydrophobically modified for integration with lipid bilayers. Lipid-integrated DNA nanotechnology can allow for the study of membrane proteins and other fundamental biological processes. In this thesis, switchable lipid-interacting DNA origami nanostructures are introduced. First, dimeric DNA origami nanostructures are successfully programmed to monomerise upon switching. The design space of switchable DNA origami nanostructures is explored using molecular
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35

Ji, Zhouxiang. "Nano-channel of Viral DNA Packaging Motor as Single Pore to Differentiate Peptides." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555016293008571.

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36

Entwistle, Ngai Mun Aiman. "Actuation of DNA cages and their potential biological applications." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:0983ed77-77f6-4d15-9187-52aff44299ec.

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DNA cages are polyhedra self-assembled from synthetic oligonucleotides in a one-pot process. The main system described in this thesis is a reconfigurable, wire-framed DNA tetrahedron in nanometre-scale. On one of its vertices this tetrahedron has an overhang that can hybridise with a specific sequence of nucleic acids and open the cage. We describe the design of a reconfigurable cage that remained closed under physiological conditions and only opened in the presence of an appropriate signal in solution. Fluorescence techniques were employed to distinguish the open and closed states of the cage
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37

Fahrenkopf, Nicholas M. "Probe immobilization strategies and device optimization for novel transistor-based DNA sensors." Thesis, State University of New York at Albany, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3558154.

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<p> The research presented herein exploits the terminal phosphate group on single stranded DNA molecules for direct immobilization to surfaces utilized in semiconductor device fabrication with the end goal of transistor based DNA sensors. As a demonstration of the feasibility of this immobilization strategy DNA immobilization to a variety of surfaces was evaluated for usefulness in biosensor applications. It was determined that DNA can be directly immobilized to a variety of semiconductor surfaces through the terminal phosphate group. Further, this immobilization allows for the hybridization o
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38

Boemo, Michael Austin. "Computation by origami-templated DNA walkers." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:bdea667e-a9aa-484a-9db0-a816339e5594.

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Interactions between DNA molecules can be used to perform computation. These DNA computing systems often use DNA molecules as freely diusing reactants in a well-mixed solution. We demonstrate how DNA walkers tethered to an origami-templated track can perform computation. A DNA walker can block a track that intersects with its own, preventing another walker from stepping down this blocked track. These blockages are primitive operations that can be used to perform computation. This thesis demonstrates how blocking interactions between DNA walkers can evaluate formulae posed in propositional logi
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39

Johnson, Joshua A. Dr. "Control of DNA Origami from Self-Assembly to Higher-Order Assembly." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1577996668813983.

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40

Yamamoto, Seigi. "Design and Evaluation of DNA Nano-devices Using DNA Origami Method and Fluorescent Nucleobase Analogues." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215338.

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Lucas, Alexandra. "Dynamic DNA motors and structures." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:5f0b0773-a7af-4edb-a6a2-790a0086553d.

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DNA nanotechnology uses the Watson-Crick base-pairing of DNA to self-assemble structures at the nanoscale. DNA nanomachines are active structures that take energy from the system to drive a programmed motion. In this thesis, a new design for a reversible DNA motor and an automatically regenerating track is presented. Ensemble fluorescence measurements observe motors walking along the same 42nm track three times. A second new motor was designed to allow motors on intersecting tracks to block each other, which can be used to perform logical computation. Multiple design approaches are discussed.
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42

Bader, Antoine. "DNA-based logic." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31065.

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DNA nanotechnology has been developed in order to construct nanostructures and nanomachines by virtue of the programmable self-assembly properties of DNA molecules. Although DNA nanotechnology initially focused on spatial arrangement of DNA strands, new horizons have been explored owing to the development of the toehold-mediated strand-displacement reaction, conferring new dynamic properties to previously static and rigid structures. A large variety of DNA reconfigurable nanostructures, stepped and autonomous nanomachines and circuits have been operated using the strand-displacement reaction.
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Quach, Ashley Dung. "Design and Development of Nanoconjugates for Nanotechnology." ScholarWorks@UNO, 2011. http://scholarworks.uno.edu/td/130.

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Nanotechnology builds devices from the bottom up with atomic accuracy. Among the basic nano-components to fabricate such devices, semiconductor nanoparticle quantum dots (QDs), metal nanocrystals, proteins, and nucleic acids have attracted most interests due to their potential in optical, biomedical, and electronic areas. The major objective of this research was to prepare nano-components in order to fabricate functional nano-scale devices. This research consisted of three projects. In the first two projects, we incorporated two desirable characteristics of QDs, which are their abilities to se
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44

Yata, Tomoya. "Development of efficient amplification method of DNA hydrogel and composite-type DNA hydrogel for photothermal immunotherapy." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215494.

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45

Dunn, Katherine Elizabeth. "DNA origami assembly." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:dff1bafd-e355-4df5-968b-b0deb7e6f44f.

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This thesis describes my investigations into the principles underlying self-assembly of DNA origami nanostructures and discusses how these principles may be applied. To study the origami folding process I designed, synthesized and characterized a polymorphic tile, which could adopt various shapes. The distribution of tile shapes provided new insights into assembly. The origami tiles I studied were based on scaffolds derived from customized plasmids, which I prepared using recombinant DNA technology. I developed a technique to monitor incorporation of individual staples in real time using fluor
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Haley, Natalie Emma Charnell. "Structures and mechanisms for synthetic DNA motors." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:7bcdd990-cb31-40f2-b85b-4a9a1630eafb.

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DNA provides an ideal substrate for nanoscale construction and programmable dynamic mechanisms. DNA mechanisms can be used to produce DNA motors which do mechanical work, e.g. transportation of a substrate along a track. I explore a method for control of a DNA mechanism ubiquitous in DNA motor designs, toehold-mediated strand displacement, by which one strand in a duplex can be swapped for another. My method uses a mismatch between a pair of nucleotides in the duplex, which is repaired by displacement. I find that displacement rate can be fine-tuned by adjusting the position of the mismatch in
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47

Becerril-Garcia, Hector Alejandro. "DNA-Templated Nanomaterials." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1823.pdf.

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48

Miller, Carl A. "Control of Dynamic DNA Origami Mechanisms Using Integrated Functional Components." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429812012.

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49

Bachem, Gunnar. "Investigation of Cooperativity between Statistical Rebinding and the Chelate Effect on DNA Scaffolded Multivalent Binders as a Method for Developing High Avidity Ligands to target the C-type Lectin Langerin." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22787.

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Abstract:
Aufgrund der Fähigkeit von Langerhans Zellen, welche den C-Typ Lektin (CTL) Rezeptor Langerin exprimieren, Antigene zu internalisieren und T-Zellen zu präsentieren, wurde Langerin als attraktives Ziel für neue Immunotherapien erkannt. Langerin kann Pathogene wie z.B. Viren erkennen, die zur Erhöhung der Avidität Kohlenhydratliganden multivalent präsentieren, da die monovalenten Kohlenhydratliganden nur niedrige Affinitäten für Langerin aufweisen. Die natürlichen monovalenten Kohlenhydratliganden besitzen nur niedrige Affinitäten für Langerin. Inspiriert durch die Natur stellt Multivalenz eine
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Zhou, Lifeng. "Design Modeling and Analysis of Compliant and Rigid-Body DNA Origami Mechanisms." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492793740662906.

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