Log in

Relevant bibliographies by topics / DNA origami mechanisms and machines / Journal articles

To see the other types of publications on this topic, follow the link: DNA origami mechanisms and machines.

Journal articles on the topic 'DNA origami mechanisms and machines'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'DNA origami mechanisms and machines.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Su, Hai-Jun, and Carlos E. Castro. "The Rise of the DNA Nanorobots." Mechanical Engineering 138, no. 08 (2016): 44–49. http://dx.doi.org/10.1115/1.2016-aug-3.

Full text

Abstract:

This article is a study of various aspects of design of DNA nanorobots. When designed properly, DNA folds into tiny devices that move like macroscopic machines. Researchers have built a large and growing variety of complex DNA origami structures, including nanotubes; nanopores; and templates for proteins, nanoparticles, small molecules, and carbon nanotubes. In order to design the motion of a robotic arm or other macroscopic mechanism, engineers use the principles of kinematics; the same principles have been used to design DNA origami mechanisms. The design process for DNA origami mechanisms i

APA, Harvard, Vancouver, ISO, and other styles

2

Marras, Alexander E., Lifeng Zhou, Hai-Jun Su, and Carlos E. Castro. "Programmable motion of DNA origami mechanisms." Proceedings of the National Academy of Sciences 112, no. 3 (2015): 713–18. http://dx.doi.org/10.1073/pnas.1408869112.

Full text

Abstract:

DNA origami enables the precise fabrication of nanoscale geometries. We demonstrate an approach to engineer complex and reversible motion of nanoscale DNA origami machine elements. We first design, fabricate, and characterize the mechanical behavior of flexible DNA origami rotational and linear joints that integrate stiff double-stranded DNA components and flexible single-stranded DNA components to constrain motion along a single degree of freedom and demonstrate the ability to tune the flexibility and range of motion. Multiple joints with simple 1D motion were then integrated into higher orde

APA, Harvard, Vancouver, ISO, and other styles

3

Endo, Masayuki, and Hiroshi Sugiyama. "DNA Origami Nanomachines." Molecules 23, no. 7 (2018): 1766. http://dx.doi.org/10.3390/molecules23071766.

Full text

Abstract:

DNA can assemble various molecules and nanomaterials in a programmed fashion and is a powerful tool in the nanotechnology and biology research fields. DNA also allows the construction of desired nanoscale structures via the design of DNA sequences. Structural nanotechnology, especially DNA origami, is widely used to design and create functionalized nanostructures and devices. In addition, DNA molecular machines have been created and are operated by specific DNA strands and external stimuli to perform linear, rotational, and reciprocating movements. Furthermore, complicated molecular systems ha

APA, Harvard, Vancouver, ISO, and other styles

4

Marras, Alexander E. "Fabricating and Actuating DNA Origami Mechanisms." Biophysical Journal 112, no. 3 (2017): 301a. http://dx.doi.org/10.1016/j.bpj.2016.11.1629.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Felton, S., M. Tolley, E. Demaine, D. Rus, and R. Wood. "A method for building self-folding machines." Science 345, no. 6197 (2014): 644–46. http://dx.doi.org/10.1126/science.1252610.

Full text

Abstract:

Origami can turn a sheet of paper into complex three-dimensional shapes, and similar folding techniques can produce structures and mechanisms. To demonstrate the application of these techniques to the fabrication of machines, we developed a crawling robot that folds itself. The robot starts as a flat sheet with embedded electronics, and transforms autonomously into a functional machine. To accomplish this, we developed shape-memory composites that fold themselves along embedded hinges. We used these composites to recreate fundamental folded patterns, derived from computational origami, that ca

APA, Harvard, Vancouver, ISO, and other styles

6

Wang, Shuang, Zhaoyu Zhou, Ningning Ma, et al. "DNA Origami-Enabled Biosensors." Sensors 20, no. 23 (2020): 6899. http://dx.doi.org/10.3390/s20236899.

Full text

Abstract:

Biosensors are small but smart devices responding to the external stimulus, widely used in many fields including clinical diagnosis, healthcare and environment monitoring, etc. Moreover, there is still a pressing need to fabricate sensitive, stable, reliable sensors at present. DNA origami technology is able to not only construct arbitrary shapes in two/three dimension but also control the arrangement of molecules with different functionalities precisely. The functionalization of DNA origami nanostructure endows the sensing system potential of filling in weak spots in traditional DNA-based bio

APA, Harvard, Vancouver, ISO, and other styles

7

Ariga, Katsuhiko, Taizo Mori, Waka Nakanishi, and Jonathan P. Hill. "Solid surface vs. liquid surface: nanoarchitectonics, molecular machines, and DNA origami." Physical Chemistry Chemical Physics 19, no. 35 (2017): 23658–76. http://dx.doi.org/10.1039/c7cp02280h.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Halley, Patrick D., Christopher R. Lucas, Emily M. McWilliams, et al. "DNA Origami: Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model (Small 3/2016)." Small 12, no. 3 (2016): 307. http://dx.doi.org/10.1002/smll.201670014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Li, Ruixin, Haorong Chen, Hyeongwoon Lee, and Jong Hyun Choi. "Conformational Control of DNA Origami by DNA Oligomers, Intercalators and UV Light." Methods and Protocols 4, no. 2 (2021): 38. http://dx.doi.org/10.3390/mps4020038.

Full text

Abstract:

DNA origami has garnered great attention due to its excellent programmability and precision. It offers a powerful means to create complex nanostructures which may not be possible by other methods. The macromolecular structures may be used as static templates for arranging proteins and other molecules. They are also capable of undergoing structural transformation in response to external signals, which may be exploited for sensing and actuation at the nanoscale. Such on-demand reconfigurations are executed mostly by DNA oligomers through base-pairing and/or strand displacement, demonstrating dra

APA, Harvard, Vancouver, ISO, and other styles

10

Zhou, Lifeng, Alexander E. Marras, Hai-Jun Su, and Carlos E. Castro. "Direct Design of an Energy Landscape with Bistable DNA Origami Mechanisms." Nano Letters 15, no. 3 (2015): 1815–21. http://dx.doi.org/10.1021/nl5045633.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Linko, Veikko, Seppo-Tapio Paasonen, Anton Kuzyk, Päivi Törmä, and J. Jussi Toppari. "Characterization of the Conductance Mechanisms of DNA Origami by AC Impedance Spectroscopy." Small 5, no. 21 (2009): 2382–86. http://dx.doi.org/10.1002/smll.200900683.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Kim, Woongbae, Junghwan Byun, Jae-Kyeong Kim, et al. "Bioinspired dual-morphing stretchable origami." Science Robotics 4, no. 36 (2019): eaay3493. http://dx.doi.org/10.1126/scirobotics.aay3493.

Full text

Abstract:

Nature demonstrates adaptive and extreme shape morphing via unique patterns of movement. Many of them have been explained by monolithic shape-changing mechanisms, such as chemical swelling, skin stretching, origami/kirigami morphing, or geometric eversion, that were successfully mimicked in artificial analogs. However, there still remains an unexplored regime of natural morphing that cannot be reproduced in artificial systems by a “single-mode” morphing mechanism. One example is the “dual-mode” morphing of Eurypharynx pelecanoides (commonly known as the pelican eel), which first unfolds and th

APA, Harvard, Vancouver, ISO, and other styles

13

Roodhuizen, Job A. L., Philip J. T. M. Hendrikx, Peter A. J. Hilbers, Tom F. A. de Greef, and Albert J. Markvoort. "Counterion-Dependent Mechanisms of DNA Origami Nanostructure Stabilization Revealed by Atomistic Molecular Simulation." ACS Nano 13, no. 9 (2019): 10798–809. http://dx.doi.org/10.1021/acsnano.9b05650.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Halley, Patrick D., Christopher R. Lucas, Emily M. McWilliams, et al. "Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model." Small 12, no. 3 (2015): 308–20. http://dx.doi.org/10.1002/smll.201502118.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Attali, Ilan, Michael R. Botchan, and James M. Berger. "Structural Mechanisms for Replicating DNA in Eukaryotes." Annual Review of Biochemistry 90, no. 1 (2021): 77–106. http://dx.doi.org/10.1146/annurev-biochem-090120-125407.

Full text

Abstract:

The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein–nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.

APA, Harvard, Vancouver, ISO, and other styles

16

Zhou, Lifeng, Hai-Jun Su, Alexander E. Marras, Chao-Min Huang, and Carlos E. Castro. "Projection kinematic analysis of DNA origami mechanisms based on a two-dimensional TEM image." Mechanism and Machine Theory 109 (March 2017): 22–38. http://dx.doi.org/10.1016/j.mechmachtheory.2016.11.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Sheheade, Breveruos, Miran Liber, Mary Popov, et al. "Self‐Assembly of DNA Origami Heterodimers in High Yields and Analysis of the Involved Mechanisms." Small 15, no. 51 (2019): 1902979. http://dx.doi.org/10.1002/smll.201902979.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Yu, Meng, Weimin Yang, Yuan Yu, Xiang Cheng, and Zhiwei Jiao. "A Crawling Soft Robot Driven by Pneumatic Foldable Actuators Based on Miura-Ori." Actuators 9, no. 2 (2020): 26. http://dx.doi.org/10.3390/act9020026.

Full text

Abstract:

Origami structures are highly demanded for engineering applications. Using origami folding to design and actuate mechanisms and machines offers attractive opportunities. In this paper, we design a crawling robot driven by pneumatic foldable actuators (PFAs) based on Miura-ori, according to the parallel foldable structure and different control patterns, which can perform different movements. The PFA inspired from Miura-ori is composed of a folding part, transition part, and sealing part, made by flexible materials and a paper skeleton. This actuator can obtain a large deformation by folding und

APA, Harvard, Vancouver, ISO, and other styles

19

Zechner, Ellen L., Silvia Lang, and Joel F. Schildbach. "Assembly and mechanisms of bacterial type IV secretion machines." Philosophical Transactions of the Royal Society B: Biological Sciences 367, no. 1592 (2012): 1073–87. http://dx.doi.org/10.1098/rstb.2011.0207.

Full text

Abstract:

Type IV secretion occurs across a wide range of prokaryotic cell envelopes: Gram-negative, Gram-positive, cell wall-less bacteria and some archaea. This diversity is reflected in the heterogeneity of components that constitute the secretion machines. Macromolecules are secreted in an ATP-dependent process using an envelope-spanning multi-protein channel. Similar to the type III systems, this apparatus extends beyond the cell surface as a pilus structure important for direct contact and penetration of the recipient cell surface. Type IV systems are remarkably versatile in that they mobilize a b

APA, Harvard, Vancouver, ISO, and other styles

20

Dillingham, Mark S. "Superfamily I helicases as modular components of DNA-processing machines." Biochemical Society Transactions 39, no. 2 (2011): 413–23. http://dx.doi.org/10.1042/bst0390413.

Full text

Abstract:

Helicases are a ubiquitous and abundant group of motor proteins that couple NTP binding and hydrolysis to processive unwinding of nucleic acids. By targeting this activity to a wide range of specific substrates, and by coupling it with other catalytic functionality, helicases fulfil diverse roles in virtually all aspects of nucleic acid metabolism. The present review takes a look back at our efforts to elucidate the molecular mechanisms of UvrD-like DNA helicases. Using these well-studied enzymes as examples, we also discuss how helicases are programmed by interactions with partner proteins to

APA, Harvard, Vancouver, ISO, and other styles

21

Ijäs, Heini, Boxuan Shen, Amelie Heuer-Jungemann, et al. "Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release." Nucleic Acids Research 49, no. 6 (2021): 3048–62. http://dx.doi.org/10.1093/nar/gkab097.

Full text

Abstract:

Abstract Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to thre

APA, Harvard, Vancouver, ISO, and other styles

22

Ketterer, Philip, Elena M. Willner, and Hendrik Dietz. "Nanoscale rotary apparatus formed from tight-fitting 3D DNA components." Science Advances 2, no. 2 (2016): e1501209. http://dx.doi.org/10.1126/sciadv.1501209.

Full text

Abstract:

We report a nanoscale rotary mechanism that reproduces some of the dynamic properties of biological rotary motors in the absence of an energy source, such as random walks on a circle with dwells at docking sites. Our mechanism is built modularly from tight-fitting components that were self-assembled using multilayer DNA origami. The apparatus has greater structural complexity than previous mechanically interlocked objects and features a well-defined angular degree of freedom without restricting the range of rotation. We studied the dynamics of our mechanism using single-particle experiments an

APA, Harvard, Vancouver, ISO, and other styles

23

Johnson, Cotteka N., Nicholas L. Adkins, and Philippe Georgel. "Chromatin remodeling complexes: ATP-dependent machines in action." Biochemistry and Cell Biology 83, no. 4 (2005): 405–17. http://dx.doi.org/10.1139/o05-115.

Full text

Abstract:

Since the initial characterization of chromatin remodeling as an ATP-dependent process, many studies have given us insight into how nucleosome-remodeling complexes can affect various nuclear functions. However, the multistep DNA-histone remodeling process has not been completely elucidated. Although new studies are published on a nearly weekly basis, the nature and roles of interactions of the individual SWI/SNF- and ISWI-based remodeling complexes and DNA, core histones, and other chromatin-associated proteins are not fully understood. In addition, the potential changes associated with ATP re

APA, Harvard, Vancouver, ISO, and other styles

24

Ho, P. Shing. "Structure of the Holliday junction: applications beyond recombination." Biochemical Society Transactions 45, no. 5 (2017): 1149–58. http://dx.doi.org/10.1042/bst20170048.

Full text

Abstract:

The Holliday junction (HJ) is an essential element in recombination and related mechanisms. The structure of this four-stranded DNA assembly, which is now well-defined alone and in complex with proteins, has led to its applications in areas well outside of molecular recombination, including nanotechnology and biophysics. This minireview explores some interesting recent research on the HJ, as it has been adapted to design regular two- or three-dimensional lattices for crystal engineering, and more complex systems through DNA origami. In addition, the sequence dependence of the structure is disc

APA, Harvard, Vancouver, ISO, and other styles

25

SHARMA, AJEET K., and DEBASHISH CHOWDHURY. "TEMPLATE-DIRECTED BIOPOLYMERIZATION: TAPE-COPYING TURING MACHINES." Biophysical Reviews and Letters 07, no. 03n04 (2012): 135–75. http://dx.doi.org/10.1142/s1793048012300083.

Full text

Abstract:

DNA, RNA and proteins are among the most important macromolecules in a living cell. These molecules are polymerized by molecular machines. These natural nano-machines polymerize such macromolecules, adding one monomer at a time, using another linear polymer as the corresponding template. The machine utilizes input chemical energy to move along the template which also serves as a track for the movements of the machine. In the Alan Turing year 2012, it is worth pointing out that these machines are "tape-copying Turing machines". We review the operational mechanisms of the polymerizer machines an

APA, Harvard, Vancouver, ISO, and other styles

26

Delagoutte, Emmanuelle, and Peter H. von Hippel. "Helicase mechanisms and the coupling of helicases within macromolecular machines Part II: Integration of helicases into cellular processes." Quarterly Reviews of Biophysics 36, no. 1 (2003): 1–69. http://dx.doi.org/10.1017/s0033583502003864.

Full text

Abstract:

1. Helicases as components of macromolecular machines 32. Helicases in replication 72.1 The loading of replicative helicases 72.1.1 Loading Rep helicase at the replication origin of bacteriophage ϕX174 72.1.2 How is a ssDNA strand passed through (and bound in?) the central channel of the hexameric replicative helicases? 82.1.3 Loading of E. coli DnaB helicase in the absence of an auxiliary protein-loading factor 82.1.4 The T7 gp4 primase-helicase is loaded by means of a facilitated ring-opening mechanism 102.1.5 Bacteriophage T4 gp61 primase can be viewed as a loading factor for the homologous

APA, Harvard, Vancouver, ISO, and other styles

27

Murray, Noreen E. "Type I Restriction Systems: Sophisticated Molecular Machines (a Legacy of Bertani and Weigle)." Microbiology and Molecular Biology Reviews 64, no. 2 (2000): 412–34. http://dx.doi.org/10.1128/mmbr.64.2.412-434.2000.

Full text

Abstract:

SUMMARY Restriction enzymes are well known as reagents widely used by molecular biologists for genetic manipulation and analysis, but these reagents represent only one class (type II) of a wider range of enzymes that recognize specific nucleotide sequences in DNA molecules and detect the provenance of the DNA on the basis of specific modifications to their target sequence. Type I restriction and modification (R-M) systems are complex; a single multifunctional enzyme can respond to the modification state of its target sequence with the alternative activities of modification or restriction. In t

APA, Harvard, Vancouver, ISO, and other styles

28

Ding, Tao, Ventsislav K. Valev, Andrew R. Salmon, et al. "Light-induced actuating nanotransducers." Proceedings of the National Academy of Sciences 113, no. 20 (2016): 5503–7. http://dx.doi.org/10.1073/pnas.1524209113.

Full text

Abstract:

Nanoactuators and nanomachines have long been sought after, but key bottlenecks remain. Forces at submicrometer scales are weak and slow, control is hard to achieve, and power cannot be reliably supplied. Despite the increasing complexity of nanodevices such as DNA origami and molecular machines, rapid mechanical operations are not yet possible. Here, we bind temperature-responsive polymers to charged Au nanoparticles, storing elastic energy that can be rapidly released under light control for repeatable isotropic nanoactuation. Optically heating above a critical temperature Tc = 32 °C using p

APA, Harvard, Vancouver, ISO, and other styles

29

Morgan, Aaron, Sarah LeGresley, and Christopher Fischer. "Remodeler Catalyzed Nucleosome Repositioning: Influence of Structure and Stability." International Journal of Molecular Sciences 22, no. 1 (2020): 76. http://dx.doi.org/10.3390/ijms22010076.

Full text

Abstract:

The packaging of the eukaryotic genome into chromatin regulates the storage of genetic information, including the access of the cell’s DNA metabolism machinery. Indeed, since the processes of DNA replication, translation, and repair require access to the underlying DNA, several mechanisms, both active and passive, have evolved by which chromatin structure can be regulated and modified. One mechanism relies upon the function of chromatin remodeling enzymes which couple the free energy obtained from the binding and hydrolysis of ATP to the mechanical work of repositioning and rearranging nucleos

APA, Harvard, Vancouver, ISO, and other styles

30

Morris, Daniel L. "DNA-bound metal ions: recent developments." Biomolecular Concepts 5, no. 5 (2014): 397–407. http://dx.doi.org/10.1515/bmc-2014-0021.

Full text

Abstract:

AbstractThe affinity of metal ions for DNA is logical considering that the structure of DNA includes a phosphate backbone with a net-negative charge, a deoxyribose sugar with O atoms, and purine and pyrimidine bases that contain O and N atoms. DNA-metal ion interactions encompass a large area of research that ranges from the most fundamental characterization of DNA-metal ion binding to the role of DNA-bound metal ions in disease and human health. Alternative DNA base pairing mediated by metal binding is also being investigated and manipulated for applications in logic gates, molecular machines

APA, Harvard, Vancouver, ISO, and other styles

31

Ramm, Beatrice, Andriy Goychuk, Alena Khmelinskaia, et al. "A diffusiophoretic mechanism for ATP-driven transport without motor proteins." Nature Physics 17, no. 7 (2021): 850–58. http://dx.doi.org/10.1038/s41567-021-01213-3.

Full text

Abstract:

AbstractThe healthy growth and maintenance of a biological system depends on the precise spatial organization of molecules within the cell through the dissipation of energy. Reaction–diffusion mechanisms can facilitate this organization, as can directional cargo transport orchestrated by motor proteins, by relying on specific protein interactions. However, transport of material through the cell can also be achieved by active processes based on non-specific, purely physical mechanisms, a phenomenon that remains poorly explored. Here, using a combined experimental and theoretical approach, we di

APA, Harvard, Vancouver, ISO, and other styles

32

Delagoutte, Emmanuelle, and Peter H. von Hippel. "Helicase mechanisms and the coupling of helicases within macromolecular machines Part I: Structures and properties of isolated helicases." Quarterly Reviews of Biophysics 35, no. 4 (2002): 431–78. http://dx.doi.org/10.1017/s0033583502003852.

Full text

Abstract:

1. Mechanisms of nucleic acid (NA) unwinding by helicases 4322. Helicases may take advantage of ‘breathing’ fluctuations in dsNAs 4342.1 Stability and dynamics of dsNAs 4342.2 dsNAs ‘breathe’ in isolation 4352.3 Thermodynamics of terminal base pairs of dsNA 4382.4 Thermal fluctuations may be responsible for sequential base-pair opening at replication forks 4392.5 Helicases may capture single base-pair opening events sequentially 4403. Biochemical properties of helicases 4433.1 Binding of NAs 4433.2 Binding and hydrolysis of NTP 4453.3 Coordination between NA binding and NTP binding and hydroly

APA, Harvard, Vancouver, ISO, and other styles

33

Mirkin, Ekaterina V., and Sergei M. Mirkin. "Replication Fork Stalling at Natural Impediments." Microbiology and Molecular Biology Reviews 71, no. 1 (2007): 13–35. http://dx.doi.org/10.1128/mmbr.00030-06.

Full text

Abstract:

SUMMARY Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way. Such obstacles can be called natural impediments to DNA replication, as opposed to external and genetic factors. Natural impediments to DNA replication are particular DNA binding

APA, Harvard, Vancouver, ISO, and other styles

34

Mercier, Romain, Sarah Bautista, Maëlle Delannoy, et al. "The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility inMyxococcus xanthus." Proceedings of the National Academy of Sciences 117, no. 45 (2020): 28366–73. http://dx.doi.org/10.1073/pnas.2002783117.

Full text

Abstract:

Type IV pili (Tfp) are highly conserved macromolecular structures that fulfill diverse cellular functions, such as adhesion to host cells, the import of extracellular DNA, kin recognition, and cell motility (twitching). Outstandingly, twitching motility enables a poorly understood process by which highly coordinated groups of hundreds of cells move in cooperative manner, providing a basis for multicellular behaviors, such as biofilm formation. In the social bacteriaMyxococcus xanthus, we know that twitching motility is under the dependence of the small GTPase MglA, but the underlying molecular

APA, Harvard, Vancouver, ISO, and other styles

35

Melnick, Ari M., Kerin Adelson, and Jonathan D. Licht. "The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put Into Practice?" Journal of Clinical Oncology 23, no. 17 (2005): 3957–70. http://dx.doi.org/10.1200/jco.2005.14.498.

Full text

Abstract:

Aberrant gene silencing is a frequent event in cancer and plays a critical role in the molecular pathogenesis of malignant transformation. The two major mechanisms of silencing in cancer include transcriptional repression by mutated or aberrantly expressed transcription factors, and aberrant epigenetic silencing by hypermethylation of tumor suppressor or DNA repair–related genes. Both of these mechanisms require the activities of multiprotein chromatin remodeling and modifying machines, several of which may be mutated in cancer. The end result is genetic reprogramming of cells to express combi

APA, Harvard, Vancouver, ISO, and other styles

36

Selvaraj, Chandrabose, and Sanjeev K. Singh. "Computational and Experimental Binding Mechanism of DNA-drug Interactions." Current Pharmaceutical Design 24, no. 32 (2019): 3739–57. http://dx.doi.org/10.2174/1381612824666181106101448.

Full text

Abstract:

Nucleic acid is the key unit and a predominant genetic material for interpreting the fundamental basis of genetic information in an organism and now it is used for the evolution of a novel group of therapeutics. To identify the potential impact on the biological science, it receives high recognition in therapeutic applications. Due to its selective recognition of molecular targets and pathways, DNA significantly imparts tremendous specificity of action. Examining the properties of DNA holds numerous advantages in assembly, interconnects, computational elements, along with potential application

APA, Harvard, Vancouver, ISO, and other styles

37

Ariga, Katsuhiko, Michio Matsumoto, Taizo Mori, and Lok Kumar Shrestha. "Materials nanoarchitectonics at two-dimensional liquid interfaces." Beilstein Journal of Nanotechnology 10 (July 30, 2019): 1559–87. http://dx.doi.org/10.3762/bjnano.10.153.

Full text

Abstract:

Much attention has been paid to the synthesis of low-dimensional materials from small units such as functional molecules. Bottom-up approaches to create new low-dimensional materials with various functional units can be realized with the emerging concept of nanoarchitectonics. In this review article, we overview recent research progresses on materials nanoarchitectonics at two-dimensional liquid interfaces, which are dimensionally restricted media with some freedoms of molecular motion. Specific characteristics of molecular interactions and functions at liquid interfaces are briefly explained

APA, Harvard, Vancouver, ISO, and other styles

38

Jones, Peter A. "Decoding the Chromatin Code." Blood 120, no. 21 (2012): SCI—4—SCI—4. http://dx.doi.org/10.1182/blood.v120.21.sci-4.sci-4.

Full text

Abstract:

Abstract Abstract SCI-4 Epigenetic processes are reinforced by interactions between covalent chromatin marks such as DNA methylation, histone modifications, and variants thereof. These marks ultimately specify the locations of nucleosomes, particularly with respect to transcriptional start sites and other regulatory regions. Understanding how the epigenome functions, therefore, requires a coordinated approach in order to reveal the mechanisms by which the chemical modifications interact with nucleosomal remodeling machines to ensure epigenetic inheritance and control of gene expression. We hav

APA, Harvard, Vancouver, ISO, and other styles

39

Iglesias, María Sanromán, and Marek Grzelczak. "Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy." Beilstein Journal of Nanotechnology 11 (January 31, 2020): 263–84. http://dx.doi.org/10.3762/bjnano.11.20.

Full text

Abstract:

The possibility of detecting genetic mutations rapidly in physiological media through liquid biopsy has attracted the attention within the materials science community. The physical properties of nanoparticles combined with robust transduction methods ensure an improved sensitivity and specificity of a given assay and its implementation into point-of-care devices for common use. Covering the last twenty years, this review gives an overview of the state-of-the-art of the research on the use of gold nanoparticles in the development of colorimetric biosensors for the detection of single-nucleotide

APA, Harvard, Vancouver, ISO, and other styles

40

Harris, Sarah Anne. "Modelling the biomechanical properties of DNA using computer simulation." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 364, no. 1849 (2006): 3319–34. http://dx.doi.org/10.1098/rsta.2006.1906.

Full text

Abstract:

Duplex DNA must remain stable when not in use to protect the genetic material. However, the two strands must be separated whenever genes are copied or expressed to expose the coding strand for synthesis of complementary RNA or DNA bases. Therefore, the double stranded structure must be relatively easy to take apart when required. These conflicting biological requirements have important implications for the mechanical properties of duplex DNA. Considerable insight into the forces required to denature DNA has been provided by nanomanipulation experiments, which measure the mechanical properties

APA, Harvard, Vancouver, ISO, and other styles

41

Sundaramoorthy, Ramasubramanian. "Nucleosome remodelling: structural insights into ATP-dependent remodelling enzymes." Essays in Biochemistry 63, no. 1 (2019): 45–58. http://dx.doi.org/10.1042/ebc20180059.

Full text

Abstract:

Abstract ATP-dependent chromatin remodelling enzymes play a fundamental role in determining how nucleosomes are organised, and render DNA sequences accessible to interacting proteins, thereby enabling precise regulation of eukaryotic genes. Remodelers conserved from yeast to humans are classified into four families based on the domains and motifs present in their ATPase subunits. Insights into overall assembly and the mode of interaction to the nucleosome by these different families of remodelers remained limited due to the complexity of obtaining structural information on these challenging sa

APA, Harvard, Vancouver, ISO, and other styles

42

Putnam, Christopher D., Michal Hammel, Greg L. Hura, and John A. Tainer. "X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution." Quarterly Reviews of Biophysics 40, no. 3 (2007): 191–285. http://dx.doi.org/10.1017/s0033583507004635.

Full text

Abstract:

AbstractCrystallography supplies unparalleled detail on structural information critical for mechanistic analyses; however, it is restricted to describing low energy conformations of macromolecules within crystal lattices. Small angle X-ray scattering (SAXS) offers complementary information about macromolecular folding, unfolding, aggregation, extended conformations, flexibly linked domains, shape, conformation, and assembly state in solution, albeit at the lower resolution range of about 50 Å to 10 Å resolution, but without the size limitations inherent in NMR and electron microscopy studies.

APA, Harvard, Vancouver, ISO, and other styles

43

Vu, Martin, and Henning Fernau. "Adding Matrix Control: Insertion-Deletion Systems with Substitutions III." Algorithms 14, no. 5 (2021): 131. http://dx.doi.org/10.3390/a14050131.

Full text

Abstract:

Insertion-deletion systems have been introduced as a formalism to model operations that find their counterparts in ideas of bio-computing, more specifically, when using DNA or RNA strings and biological mechanisms that work on these strings. So-called matrix control has been introduced to insertion-deletion systems in order to enable writing short program fragments. We discuss substitutions as a further type of operation, added to matrix insertion-deletion systems. For such systems, we additionally discuss the effect of appearance checking. This way, we obtain new characterizations of the fami

APA, Harvard, Vancouver, ISO, and other styles

44

Sugiyama, Hiroshi. "2SI-06 Direct Observation of Single Molecular Event in DNA Origami Frame(2SI The art of energetic and functional efficiency in biomoiecular machines on the single molecule level,Symposium,The 50th Annual Meeting of the Biophysical Society of Japan)." Seibutsu Butsuri 52, supplement (2012): S18. http://dx.doi.org/10.2142/biophys.52.s18_2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Pi, Fengmei, Zhengyi Zhao, Venkata Chelikani, Kristine Yoder, Mamuka Kvaratskhelia, and Peixuan Guo. "Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism." Journal of Virology 90, no. 18 (2016): 8036–46. http://dx.doi.org/10.1128/jvi.00508-16.

Full text

Abstract:

The intracellular parasitic nature of viruses and the emergence of antiviral drug resistance necessitate the development of new potent antiviral drugs. Recently, a method for developing potent inhibitory drugs by targeting biological machines with high stoichiometry and a sequential-action mechanism was described. Inspired by this finding, we reviewed the development of antiviral drugs targeting viral DNA-packaging motors. Inhibiting multisubunit targets with sequential actions resembles breaking one bulb in a series of Christmas lights, which turns off the entire string. Indeed, studies on vi

APA, Harvard, Vancouver, ISO, and other styles

46

Datta, Asijit. "(DIS)ABLING BODY AND CONSCIOUSNESS: TECHNOLOGICAL AFTERNESS AND AFTER-HUMANS IN REALIVE AND UPGRADE." Trabalhos em Linguística Aplicada 58, no. 2 (2019): 704–18. http://dx.doi.org/10.1590/010318135360515822019.

Full text

Abstract:

ABSTRACT My paper talks about post-human spaces and technological afterness associated with the physiognomy of humans. Mechanical alteration in biological mechanisms is directly experienced in seizing of organic consciousness. The rupture in consciousness splits it into two distinct parts-one belonging to the disappearing human, the other to the emerging cybernetic. The new being is not another human, but (an)other human, an evolved different sameness. In the film Realive (2016) we encounter an extension of the self beyond death by re-placing it into another body. However, this enhancement dif

APA, Harvard, Vancouver, ISO, and other styles

47

Hood, David A. "Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscleThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process." Applied Physiology, Nutrition, and Metabolism 34, no. 3 (2009): 465–72. http://dx.doi.org/10.1139/h09-045.

Full text

Abstract:

Acute exercise initiates rapid cellular signals, leading to the subsequent activation of proteins that increase gene transcription. The result is a higher level of mRNA expression, often observed during the recovery period following exercise. These molecules are translated into precursor proteins for import into preexisting mitochondria. Once inside the organelle, the protein is processed to its mature form and either activates mitochondrial DNA gene expression, serves as a single subunit enzyme, or is incorporated into multi-subunit complexes of the respiratory chain devoted to electron trans

APA, Harvard, Vancouver, ISO, and other styles

48

Evans, S. K., and V. Lundblad. "A nuclear tale of two yeasts." Journal of Cell Science 114, no. 10 (2001): 1798–99. http://dx.doi.org/10.1242/jcs.114.10.1798.

Full text

Abstract:

The Yeast Nucleus edited by P. Fantes and J. Beggs Oxford University Press (2000) 338 pages. ISBN 0–19-963772-5?32.50 Without question, numerous studies in yeast and mammals have revealed a striking commonality of underlying mechanisms that govern basic biological operations. Perhaps the most famous example from recent years has been the recognition that genes required for maintaining the yeast genome play a critical role in preventing cancer in humans. However, examining the molecular differences - the variations on a common theme, so to speak - can also be useful for understanding core biolo

APA, Harvard, Vancouver, ISO, and other styles

49

García-Río, Luis. "Preface." Pure and Applied Chemistry 81, no. 4 (2009): iv. http://dx.doi.org/10.1351/pac20098104iv.

Full text

Abstract:

The 19th IUPAC Conference on Physical Organic Chemistry (ICPOC-19) was held at the University of Santiago de Compostela, Santiago, Spain, 13-18 July 2008 under the local auspices of the Universities of Santiago, A Coruña, and Vigo. About 400 delegates attended ICPOC-19 from 39 countries, to participate in a scientific program comprising 11 plenary lectures, 22 invited lectures, 102 oral communications, and 224 posters.Physical organic chemistry, the study of the interrelationships between structure and reactivity in organic molecules, is a relatively young subfield of organic chemistry. At the

APA, Harvard, Vancouver, ISO, and other styles

50

Louvard, D. "In vitro assays, semi-intact cells, intact cells: what's next for studies of membrane trafficking?" Journal of Cell Science 113, no. 2 (2000): 179–80. http://dx.doi.org/10.1242/jcs.113.2.179.

Full text

Abstract:

One of the last Nobel Prizes for Medicine and Physiology of this century was awarded to Gunther Blobel for his pioneering work on the mechanisms of secretion in eukaryotic and prokaryotic cells. This prize for molecular cell biology followed that awarded to George Palade, Christian DeDuve and Albert Claude in 1974 and demonstrated that the control of the subcellular localization of proteins is achieved by molecular machines that read ‘addresses’ that are embedded in the primary sequence of a protein. In the case of secretory proteins, these addresses are known as signal sequences. Sorting of p

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!