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Dissertations / Theses on the topic 'DNA replication'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Carrington, James T. "Post-replicative resolution of under-replication." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/f0a89d2a-6ee2-4175-ba65-d58aaaee4e24.

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The evolutionary pressure to prevent re-replication by inactivating licensing during S phase leaves higher-eukaryotes with large genomes, such as human cells, vulnerable to replication stresses. Origins licensed in G1 must be sufficient to complete replication as new origins cannot be licensed in response to irreversible replication fork stalling. Interdisciplinary approaches between cellular biology and biophysics predict that replication of the genome is routinely incomplete in G2, even in the absence of external stressors. The frequency of converging replication forks that never terminate d

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2

Rytkönen, A. (Anna). "The role of human replicative DNA polymerases in DNA repair and replication." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514281381.

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Abstract The maintenance of integrity of the genome is essential for a cell. DNA repair and faithful DNA replication ensure the stability of the genome. DNA polymerases (pols) are the enzymes that synthesise DNA, a process important both in DNA replication and repair. In DNA replication DNA polymerases duplicate the genome during S phase prior to cell division. Pols α, δ, and ε are implicated in chromosomal DNA replication, but their exact function in replication is not yet completely clear. The mechanisms of different repair pathways and proteins involved are not yet completely characterised

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3

Chen, Shuhua. "Multiple mechanisms regulate the human replication factors : replication protein A and DNA polymerase alpha-during DNA replication and DNA repair /." [S.l. : s.n.], 2003.

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4

Anderson, Mary E. Ph D. (Mary Elizabeth)Massachusetts Institute of Technology. "Regulation of DNA replication and the replication initiator, DnaA, in Bacillus subtilis." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121876.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from PDF version of thesis. "February 2019."<br>Includes bibliographical references (pages 118-128).<br>DNA replication is a highly regulated process across all organisms. Improper regulation of DNA replication can be detrimental. I identified an overinitiating, conditional synthetic lethal mutant of Bacillus subtilis. I isolated suppressors of this mutant and uncovered novel genes associated with DNA replication. These suppressors acted both at the steps of initiation and elongation to overcome the

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5

Tavares, de Araujo Felipe. "DNA replication and methylation." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37847.

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One of the main questions of modern biology is how our cells interpret our genetic and epigenetic information. DNA methylation is a covalent modification of the genome that is essential for mammalian development and plays an important role in the control of gene expression, genomic imprinting and X-chromosome inactivation (Bird and Wolffe, 1999; Szyf et al., 2000). Furthermore, changes in DNA methylation and DNA methyltransferase 1 (DNMT1) activity have been widely documented in a number of human cancers (Szyf, 1998a; Szyf et al., 2000).<br>In Escherichia coli, timing and frequency of initiati

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6

Upton, Amy Louise. "Replication of damaged DNA." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/11332/.

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DNA is under constant attack from numerous damaging agents and our cells deal with thousands of lesions every day. With such constant damage it is inevitable that the template will not be completely cleared of lesions before the replication complex arrives. The consequences of the replisome meeting an obstacle will depend upon the nature of the obstacle. I have focussed upon replication in Escherichia coli and the effect of UV-induced lesions, which would block synthesis by the replicative polymerases. It is accepted that a UV lesion in the lagging strand template can be bypassed by the replis

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7

Borazjani, Gholami Farimah. "Role of replicative primase in lesion bypass during DNA replication." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68762/.

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Maintenance of genome integrity and stability is fundamental for any form of life. This is complicated as DNA is highly reactive and always under attack from a wide range of endogenous and exogenous sources which can lead to different damages in the DNA. To preserve the integrity of DNA replication, cells hav evolved a variety of DNA repair pathways. DNA damage tolerance mechanisms serve as the last line of defence to rescue the stalled replications forks. TLS, error-prone type of DNA damage tolerance, acts to bypass DNA lesions and allows continuation of DNA replication. Surprisingly majority

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8

Pearson, Christopher Edmund. "DNA cruciforms and mammalian origins of DNA replication." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28503.

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The objective of the research in this thesis is to investigate, at the molecular level, the sequences and/or structures involved in the initiation of mammalian DNA replication and to investigate the protein interactions with DNA cruciforms which have been implicated in the process of replication initiation. Four plasmids containing monkey (CV-1) early replicating nascent origin enriched sequences (ors), which had been shown previously to replicate autonomously in transfected CV-1, COS-7 and HeLa cells, were used in the establishment of an in vitro DNA replication system that uses HeLa cell ext

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9

Schorr, Stephanie. "Replication of Bulky DNA Adducts." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-125267.

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10

Bennett, Ellen R. (Ellen Ruth). "Activation of papovavirus DNA replication." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70232.

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To define the viral target sites of cellular permissive factors, simian virus 40-polyomavirus hybrid origins for DNA replication were formed by joining the auxiliary domain of one viral origin to the origin core of the other, and vice versa. The replicative capacity of these constructs were assessed in a number of mouse and monkey cell lines which express the large T antigen of polyomavirus or SV40. The results of this analysis showed that the auxiliary domains of the viral replication origins could substitute for one another in DNA replication, provided that the viral origin core and its cogn

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11

Thomas, C. M. "Cauliflower mosaic virus DNA replication." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374828.

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12

King, Arusha. "Replication of wheat chloroplast DNA." Thesis, University of Hertfordshire, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314575.

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13

Fennessy, Ross. "Chromatin dynamics during DNA replication." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/7898ad5c-ea45-4ce5-a6b7-9b858615368e.

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The primary level of chromatin organisation consists of arrays of nucleosomes that are present across the genetic template. Advances in the post genomics era have made it possible to determine the positions of nucleosomes genome-wide where it has been observed that nucleosomes adopt a distinct organisation with respect to genetic and trans-binding elements. Amongst the best studied of these is the transcription start site where it has been observed that genic nucleosome locations are well maintained with respect to promoters. DNA and chromatin replication are coupled processes whereby chromati

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14

Monaghan, Alan. "Mechanisms of adenovirus DNA replication." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/13935.

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The development of a cell-free system in which adenovirus DNA synthesis can be initiated in vitro by using the viral genome or plasmids containing the origin of replication as template has led to the identification of the sequences important for origin function and the isolation and purification of the proteins required for viral DNA replication. In vitro studies on adenovirus types 2 and 5 have shown that their replication requires the formation of a large nucleoprotein complex. This is composed of three virally encoded proteins: adenovirus DNA polymerase, precursor terminal protein and DNA b

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15

Brümmer, Anneke. "Mathematical modelling of DNA replication." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16212.

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Bevor sich eine Zelle teilt muss sie ihr gesamtes genetisches Material verdoppeln. Eukaryotische Genome werden von einer Vielzahl von Replikationsstartpunkten, den sogenannten Origins, aus repliziert, die über das gesamte Genome verteilt sind. In dieser Arbeit wird der zugrundeliegende molekulare Mechanismus quantitativ analysiert, der für die nahezu simultane Initiierung der Origins exakt ein Mal pro Zellzyklus verantwortlich ist. Basierend auf umfangreichen experimentellen Studien, wird zunächst ein molekulares regulatorisches Netzwerk rekonstruiert, welches das Binden von Molekülen an die O

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16

Mackenney, Victoria Jane. "Human DNA ligase I in DNA replication and repair." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267515.

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17

Minchell, Nicola E. "DNA topological stress during DNA replication in Saccharomyces cerevisiae." Thesis, University of Sussex, 2019. http://sro.sussex.ac.uk/id/eprint/81222/.

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DNA topological stress impedes normal DNA replication. If topological stress is allowed to build up in front of the replication fork, the fork rotates to overcome the stress, leading to formation of DNA pre-catenanes. The formation of DNA pre-catenanes is therefore a marker of DNA topological stress. In this study, I have examined how transcription linked DNA topological stress impacts on fork rotation and on endogenous DNA damage. Transcription, similar to replication, affects the topology of the DNA; and collision between the two machineries is likely to lead to high levels of DNA topologica

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18

Isoz, Isabelle. "Role of yeast DNA polymerase epsilon during DNA replication." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1932.

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19

Tao, Liang 1960. "DNA replication in human transformed cells." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37846.

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Cell transformation and malignancy may modulate some regulatory parameters of DNA replication, resulting in altered features of initiation of DNA replication in these cells. The objectives of this research were to examine the possibility for tumor-specific DNA replication origins and activation of replication origins in human transformed cells.<br>Conventional PCR was used to detect chromosomal activities of several known and putative replication origins in four human cell lines (HeLa, NSF, WI38 and SK-MG-1). Quantitative comparison of origin activities demonstrates that origins associated wit

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20

Hameister, Heike. "Mathematical models for DNA replication machinery." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=186178.

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DNA replication and associated processes take place in all living organisms with the same constitutions. The knowledge of the duplication process, chromatin building and repair mechanisms has increased explosively over the last years, but the complex interplay of different proteins and their mechanisms are not conceived properly. During DNA replication, the DNA has to be unpacked, duplicated and finally repacked into chromatin. These steps require different proteins, e.g. new histone proteins on demand to secure an error-free and undelayed DNA replication. This thesis includes different mathem

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21

Hawkins, Michelle. "DNA replication origins in Haloferax volcanii." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10853/.

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DNA replication is fundamental to the proliferation of life. Sites of DNA replication initiation are called replication origins. Bacteria replicate from a single origin whereas eukaryotes utilise multiple origins for each chromosome. The archaeal domain includes species which replicate using multiple origins of replication in addition to those which use a single origin. Archaeal DNA replication proteins are similar to eukaryotic replication machinery. Most characterised archaeal origins are adjacent to an orc gene which encodes a homologue of the Orc1 subunit of the eukaryotic initiator protei

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22

Blow, J. J. "The control of eukaryotic DNA replication." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233674.

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One of the major limitations on research into the control of eukaryotic DNA replication has been the lack of any cell-free system that initiates DNA replication in vitro. The first part of the disseration describes the establishment of a eukaryotic system, derived from the activated eggs of the South African clawed toad, Xenopus laevis, that efficiently initiates and completes DNA replication in vitro. Using a variety of biochemical techniques I show that DNA added to the extract in the form of sperm nuclei is efficiently replicated over a period of 4 - 6 hours. Replication of nuclear DNA repr

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23

Bowmaker, Mark Richard. "Replication of the mouse mitochondrial DNA." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614689.

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24

Green, Brian M. "The consequences of DNA re-replication." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3251930.

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25

You, Zhongsheng. "Sensing and responding to DNA replication /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3055806.

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26

Cerutti, A. "ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234135.

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Oncogene Induced Senescence (OIS) is a tumor suppressive barrier that blocks cell cycle permanently. OIS results from a robust DNA damage response (DDR) activation due to oncogene-induced hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene activation, I discovered that oncogene activation alters DNA replication by increasing replication fork speed and fork stalling, while decreasing the frequency of replication initiation. This is accompanied by a prompt DDR activation. As cells approach senescence the frequency of initiation increases

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27

Muñoz, Castellano Casilda. "Understanding DNA replication of Plasmodium falciparum." Electronic Thesis or Diss., Université de Montpellier (2022-....), 2023. http://www.theses.fr/2023UMONT016.

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Le parasite Plasmodium falciparum, l’agent responsable du paludisme, a un cycle de vie complexe et emploie des stratégies de multiplication atypiques, adaptées à l'expansion rapide de la population pendant la colonisation de l'hôte et la transmission, qui ne sont pas entièrement comprises. Afin de comprendre l'initiation de la réplication de l'ADN de ce pathogène humain, mon projet s'est concentré sur deux aspects principaux de ce processus : l'identification et la caractérisation des origines de la réplication et de la machinerie de réplication.Dans la première partie de ce projet, j'ai combi

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28

Komori, Hirofumi. "Structural studies on DNA-binding proteins : DNA replication initiator and DNA photolyase." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150005.

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29

Brüning, Jan-Gert. "Underpinning replication of protein-bound DNA by the accessory replicative helicase Rep." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/8220/.

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Accurate DNA replication must occur prior to every cell division. However, replication forks often stall at sites of DNA damage and protein-DNA complexes. If not removed, these blocks can threaten the viability of both daughter cells by preventing the completion of genome duplication or by targeting of blocked forks by recombination enzymes that can result in gross chromosomal rearrangements and genome instability. The importance of minimising fork blockage has resulted in cells evolving repair systems to remove lesions from DNA whilst accessory replicative helicases can underpin replication f

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30

Martin, Eleyna. "Initiation of DNA replication in Bacillus subtilis : structural studies of the DnaA-DnaD interaction." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/53443/.

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Replication of genetic information is a vital process across all domains of life. Bacillus subtilis is considered the gram-positive model bacterium for studying DNA replication (Escherichia coli has been studied extensively as the gram-negative model) and is most representative of the ancestral phylum of prokaryotes. DNA replication has three distinct stages; initiation, elongation and termination. Replication initiation is the focus of this research and this process occurs at a single origin conserved throughout bacteria, termed oriC. B. subtilis primosomal machinery is formed of replication

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31

Feu, i. Coll Sònia. "Replication stress: mechanisms and molecules involved in DNA replication progression and reinitiation." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/669609.

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This thesis investigates the mechanisms that are activated in response to replication stress induced with hydroxyurea, an agent that causes deoxyribonucleotides depletion and arrest cells in S phase, in the non-transformed hTERT-RPE cells. The results obtained in the non- transformed cells are compared with the ones obtained with HCT116 colorectal cancer cells. Previous results indicated that, in response to an acute replication stress in hTERT-RPE, replication forks were able to restart without generating genomic instability, while in response to severe replication stress APC/CCdh1 was act

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32

Schorr, Stephanie [Verfasser]. "Replication of Bulky DNA Adducts / Stephanie Schorr." München : Verlag Dr. Hut, 2010. http://d-nb.info/100997274X/34.

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33

Brown, Stephanie Marie. "Replication of damaged DNA in mammalian cells." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445620.

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34

Beckman, Jeffrey William. "Studying DNA replication fidelity using nucleotide analogues." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3239428.

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35

Heichinger, Christian. "Characterisation of fission yeast DNA replication origins." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444737/.

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In many eukaryotic organisms the chromosomal origins of DNA replication (ORIs) are not characterised by a clearly defined consensus sequence. In this thesis using the fission yeast, for the first time I have carried out a genome-wide analysis to identify such ORIs during the mitotic and meiotic cell cycles. The data can be summarised as follows: a total of 401 ORIs were identified which were used 29 percent of the time during mitotic S-phase and were spaced every 31 kilobases (kb) on average. The same ORIs were used during pre-meiotic S-phase although with lower efficiency in most chromosomal

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36

Loveland, Anna Barbara. "Single-Molecule Studies of Eukaryotic DNA Replication." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10076.

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DNA replication is a fundamental cellular process. However, the structure and dynamics of the eukaryotic DNA replication machinery remain poorly understood. A soluble extract system prepared from Xenopus eggs recapitulates eukaryotic DNA replication outside of a cell on a variety of DNA templates. This system has been used to reveal many aspects of DNA replication using a variety of ensemble biochemical techniques. Single-molecule fluorescence imaging is a powerful tool to dissect biochemical mechanisms. By immobilizing or confining a substrate, its interaction with individual, soluble, fluore

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37

Trautinger, Brigitte W. "Interplay between DNA replication, transcription and repair." Thesis, University of Nottingham, 2002. http://eprints.nottingham.ac.uk/14281/.

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The Ruv ABC and RecBCD protein complexes together can collapse and repair arrested replication forks. With their help a fork structure can be re-established on which replication can be restarted. ruv and recB mutants are therefore quite sensitive to UV light. Their survival is greatly decreased in the absence of the signalling molecules (p)ppGpp and increased when excess (p)ppGpp is present. (p)ppGpp are the effector molecules of the stringent response, regulating adaptation to starvation and other stressful environmental changes. Absence of (p)ppGpp can be compensated for by mutations in RNA

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38

Smith, Colin. "DNA repair and replication in Streptomyces coelicolor." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329440.

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39

Wasson, Gillian Rachel. "Patterns of DNA replication in human cells." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.232846.

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40

Parkes, Vincent. "Replication of DNA by isolated wheat chloroplasts." Thesis, University of Hertfordshire, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329036.

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41

Jones, M. C. "Replication of DNA by isolated wheat chloroplasts." Thesis, University of Hertfordshire, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356358.

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42

Maloney, Michael F. (Michael Finnan). "Mechanism of Mcm10 function during DNA replication." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/119912.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2017.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>All life needs to replicate its genome completely and do so with limited errors. In eukaryotic cells, DNA replication is accomplished by a multi-stage process involving numerous protein assemblies. The core component of this process is the replicative DNA helicase

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43

Cluett, Tricia Joy. "The mechanism of mammalian mitochondrial DNA replication." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611167.

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44

Marsh, Victoria Louise. "DNA replication and chromatin in Sulfolobus solfataricus." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613746.

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45

Sarosh, Alvina. "DNA replication and segregation in Staphylococcus aureus." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16476.

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Antibiotic resistant strains of S. aureus are responsible for hospital-acquired infections around the world, and also cause serious infections in the wider community, thereby posing a serious threat to human health. Resistance genes may be chromosomally encoded and/or carried by one or more plasmids. Efficient partitioning of replicated chromosomes and plasmids ensures their faithful inheritance. The S. aureus chromosome carries a putative partitioning gene, parB, and predicted parS sites at which ParB might act. Analysis of a S. aureus parB mutant revealed an increased frequency of anucleate

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46

Wilson, Rosemary Helen Clare. "Organisation of the initiation of DNA replication." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/4802/.

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Multiple lines of evidence show that DNA replication and the proteins involved with its preparation reside at the nuclear matrix (NM). Some of these, such as cyclin E, are recruited to the NM during differentiation, implying that NM attachment may help to fix cell-type specific replication programmes, and potentially therefore restrict plasticity. However, our understanding of the interplay between the NM, the cell cycle and cell type is still limited. The aim of this PhD is to develop our understanding of the NM in relation to the preparation for DNA replication. The function of the replicati

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47

Stracker, Travis Hileman. "DNA virus interactions with host cell DNA replication and repair pathways /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3070999.

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48

Morley, Stewart Anthony. "Interactions Between the Organellar Pol1A, Pol1B, and Twinkle DNA Replication Proteins and Their Role in Plant Organelle DNA Replication." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8128.

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Plants maintain organelle genomes that are descended from ancient microbes. Ages ago, these ancient microbes were engulfed by larger cells, beginning a process of co-evolution we now call the endo-symbiotic theory. Over time, DNA from the engulfed microbe was transferred to the genome of the larger engulfing cell, eventually losing the ability to be free-living, and establishing a permanent residency in the larger cell. Similarly, the larger cell came to rely so much on the microbe it had engulfed, that it too lost its ability to survive without it. Thus, mitochondria and plastids were born. N

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49

Russell, Iain Alasdair, and n/a. "Involvement of p53 and Rad51 in adenovirus replication." University of Otago. Dunedin School of Medicine, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070521.094929.

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As an Adenovirus infects a host cell a multitude of molecular interactions occur, some driven by the virus and some driven by the cell it is infecting. Many of these areas of Adenovirus biology have been intensely studied over the last half century, however, many questions remain unanswered. The aim of this study was to investigate, more closely, a long studied molecular interaction, namely the role of the tumour suppressor p53 in the Adenovirus life cycle, and also to investigate the related, but much less studied, interaction between Adenoviruses and the host cell DNA repair machinery. Con

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50

Panciatici, Claire. "DNA replication in budding yeast : link between chromatin conformation and kinetics of replication." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS473/document.

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L’information génétique contenue dans le noyau de la cellule doit être dupliquée fidèlement afin d’être transmise aux cellules filles pendant la division cellulaire. Pour organiser leur division, les cellules suivent un cycle reproductible composé de quatre étapes appelé cycle cellulaire. La préparation et l’exécution du programme de réplication de l’ADN ont lieu pendant des phases spécifiques du cycle grâce à l’intervention de multiples partenaires protéiques et de régulateurs structuraux. En particulier, la réplication de l’ADN s’effectue sur une matrice complexe constituée d’ADN associé à d

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