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Dissertations / Theses on the topic 'DNA selectivity'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Hayes, Amy M. "Sequence Selectivity and Cytotoxicity of a Series of Azinomycin “Top-Half” Partial Structures." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218639687.

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2

Woodward, Robert L. "Azinomycin A and B epoxyamide stereochemistry relevance to DNA sequence selectivity /." Connect to resource, 2006. http://hdl.handle.net/1811/6528.

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Thesis (Honors)--Ohio State University, 2006.<br>Title from first page of PDF file. Document formatted into pages: contains xi, 29 p.; also includes graphics. Includes bibliographical references (p. 27-29). Available online via Ohio State University's Knowledge Bank.

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3

Wong-Deyrup, Siu Wah. "DNA sequence selectivity and kinetic properties of de novo designed metalloprotein dimers." Diss., University of Iowa, 2007. http://ir.uiowa.edu/etd/185.

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4

Pickup, Michael Brennan. "New methodology in the determination of sequence-selectivity in small molecule-DNA binding." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286346.

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5

Yan, Wei. "Design of artificial 6-zinc finger peptides : linker alteration and DNA binding selectivity." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/137164.

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6

Boccongelli, Marina. "Etude expérimentale de la stabilité, sélectivité d'appariement et dynamique d'oligonucléotides DNA-DNA et LNA-DNA." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210549.

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Le traitement et le diagnostic de maladies d'origine génétique suscite un grand intérêt à l'heure actuelle. De par leur spécificité d'appariement avec les acides nucléiques, les oligonucléotides possèdent un grand potentiel dans ce domaine. Ils se heurtent toutefois à des limitations majeures, dont leur faible stabilité en milieu physiologique et la difficulté qu'ils ont à franchir les membranes biologiques. De nombreuses équipes de recherche s'intéressent, afin de pallier ces limitations, à la conception et à la synthèse d'oligonucléotides chimiquement modifiés. Parmi ceux-ci, les Locked Nucl

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Rathi, Preeti [Verfasser], Daniel [Akademischer Betreuer] Summerer, and Leif [Gutachter] Dehmelt. "Isolation of genomic DNA sequences with expanded nucleobase selectivity using Transcription Activator-Like Effector Proteins / Preeti Rathi ; Gutachter: Leif Dehmelt ; Betreuer: Daniel Summerer." Dortmund : Universitätsbibliothek Dortmund, 2017. http://d-nb.info/1160443246/34.

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8

Kurtovic, Sanela. "Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis." Doctoral thesis, Uppsala University, Department of Biochemistry and Organic Chemistry, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8718.

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<p>Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. Furthermore, altering enzyme function also affords insight into how enzymes work and how natural evolution operates. </p><p>Previous investigations have explored catalytic properties in the directed evolution of mutant libraries with high sequence variation. Before this study was initiated, funct

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9

Sunderland, Peter T. "Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528371.

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10

Musetti, Caterina Livia. "Heterocyclic Cations as Potential Anticancer Agents: An Approach that Targets G-quadruplex with Different Binding Modes." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/26.

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G-quadruplex structures are found in important regions of the eukaryotic genome, such as telomeres and regulatory sequences of genes, and are likely to play important roles in regulation of biological events. The significant structural differences with duplex DNA make quadruplex DNA a very attractive target for anticancer drug design. The purpose of this study is to explore conformational space in a series of heterocyclic cations to discover novel structural motifs that can selectively bind and stabilize specific G-quadruplex arrangements. A variety of biophysical techniques such as thermal me

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11

Éthève, Loic. "Étude de l’assemblage, de la mécanique et de la dynamique des complexes ADN-protéine impliquant le développement d’un modèle « gros grains »." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1242/document.

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Les interactions ADN-protéine sont fondamentales dans de nombreux processus biologiques tels que la régulation des gènes et la réparation de l'ADN. Cette thèse est centrée sur l'analyse des propriétés physiques et dynamiques des interfaces ADN-protéine. À partir de l'étude de quatre complexes ADN-protéine, nous avons montré que l'interface ADN-protéine est dynamique et que les ponts salins et liaisons hydrogène se forment et se rompent dans une échelle de temps de l'ordre de la centaine de picosecondes. L'oscillation des chaînes latérales des résidus est dans certains cas capable de moduler la

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12

Stephens, Matthew Jon Craig. "DNA aptamers that selectively label eukaryotic cells depending on the expression of the cell surface protein, P2X7." Thesis, University of Portsmouth, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618284.

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The ATP gated cation channel P2X7, is a cell surface protein whose function and activation is linked with several human diseases. The aim of this project was to raise DNA Aptamers targeting specifically the extracellular domain of the P2X7 protein with the hope to use these new ligands as a method for the study of the biological functions of the P2X7 protein and its potential as a therapeutic target. The strategy involved isolating Aptamers that would bind to human em~ryonic kidney cells transformed with a construct which forced the cells to express native mouse P2X7 on its cell surface (POSIT

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13

Gastl, Bastian. "Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19487.

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KRAS ist eines der am häufigsten mutierten Onkogene in Darmkrebspatienten. Dies macht es zu einem guten Ansatzpunkt für gezielte Krebstherapien. Trotz jahrzehntelanger Forschungsbemühungen hat sich jedoch keines der zur Inhibition des mutierten KRAS entwickelten Medikamente klinisch etablieren können. Um eventuelle Schwachstellen von KRAS mutierten Darmkrebszellen aufzudecken, wurde in der vorliegenden Studie ein shRNA basierter Screen in CaCo2 Zellen mit konditioneller KRAS(G12V) Expression ausgeführt. Die maßangefertigte shRNA-Bibliothek umfasste 121 ausgewählte Gene, die zuvor nach MEK Inh

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14

Boturyn, Didier. "Synthèse et étude de sondes fluorescentes pour le dosage des sites abasiques de l'ADN." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10152.

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Notre projet etait de mettre au point a des fins epidemiologiques une methode globale d'evaluation des dommages subis par l'adn par des genotoxiques provenant de l'environnement ou de traitements therapeutiques antitumoraux (risque de cancer secondaire). L'approche repose sur la possibilite de transformer bon nombre de dommages subis par l'adn (bases alkylees) en une entite chimique unique et reactive : le site abasique. Pour determiner quantitativement le taux de sites abasiques formes au sein de l'adn, nous avons synthetise des molecules sondes fluorescentes capables de se fixer de maniere c

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15

Casas, Godoy Leticia. "Lipase-catalyzed purification and functionalization of Omega-3 polyunsaturated fatty acids and production of structured lipids." Thesis, Toulouse, INSA, 2012. http://www.theses.fr/2012ISAT0057/document.

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Les lipases sont des enzymes présentant un grand intérêt industriel. L’intérêt de ces enzymes a conduit à caractériser ces enzymes, à mieux comprendre leur mécanisme réactionnel et leur cinétique, et à établir des méthodes efficaces de production en système d’expression homologue et hétérologue. Plus récemment, l’ingénierie enzymatique permet d’améliorer les caractéristiques des enzymes. Ce thèse s’est fixé deux objectifs principaux: premièrement, la purification et la fonctionnalisation d’acides gras poly-insaturés de type Omega-3 (PUFAs), et spécialement l’acide cis-4, 7, 10, 13, 16, 19-doco

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16

Chou, Yi-Meen, and 周義敏. "Tuning DNA Binding Selectivity by Electrostatic Interaction:Synthesis,Binding and Sequence Selectivity." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/41166342547795572836.

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17

Yang, Chi-Kai, and 楊智凱. "Sequence-selectivity and Energetic Aspects of DNA-ligand Interactions." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/11738596775342011537.

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博士<br>東海大學<br>化學系<br>102<br>The first part of this thesis reports the study of the energetic basis of complex DNA–peptide interactions relating to allosteric interactions. In common with other designed peptides, ten new conjugates incorporating the XPRK or XHypRK motif (Hyp = hydroxyproline) attached to a N-methylpyrrole (Py) tract with a basic tail have been found to display cooperative binding to DNA involving multiple monodentate as well as interstrand bidentate interactions. Quantitative DNase I footprinting show that allosteric communication via cooperative binding to multiple sites on co

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18

周雨駿. "Sequence selectivity study of ruthenium(II) complexes binding to DNA." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/76026762404011016382.

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19

Huynh, Hang T. "Cyanine Dyes Targeting G-quadruplex DNA: Significance in Sequence and Conformation Selectivity." 2015. http://scholarworks.gsu.edu/chemistry_theses/80.

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Small molecules interacting with DNA is an emerging theme in scientific research due to its specificity and minimal side-effect. Moreover, a large amount of research has been done on finding compounds that can stabilize G-quadruplex DNA, a non-canonical secondary DNA structure, to inhibit cancerous cell proliferation. G-quadruplex DNA is found in the guanine-rich region of the chromosome that has an important role in protecting chromosomes from unwinding, participate in gene expression, contribute in the control replication of cells and more. In this research, rationally designed, synthetic

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20

Rudinger, Nicolas Zackes [Verfasser]. "New insights into selectivity of DNA polymerases : a combinatorial approach / vorgelegt von Nicolas Zackes Rudinger." 2007. http://d-nb.info/984600841/34.

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21

McKee, Mireya Loreley 1978. "Synthesis and biological evaluation of 2-(2'-hydroxyphenyl) benzoxazole analogs of UK-1 and G-quadruplex selectivity of perylene diimide compounds: /." Thesis, 2007. http://hdl.handle.net/2152/3634.

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A great number of pharmaceutical drugs target nucleic acids. However, drug-DNA interactions can be region non-specific and lead to undesired side effects. Understanding the mechanisms that regulate drug-DNA binding can help in the design of potent and selective therapeutic agents with fewer deleterious side effects. The present investigation explores the metal-mediated DNA binding of a group of 2-(2-hydroxyphenyl)benzoxazole (HPB) ligands and the aggregation dependant G-quadruplex selectivity of a series of perylene tetracarboxylic acid diimides (PTCDI) compounds. HPB ligands are simplified an

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22

Noor, Muhammad Omair. "Development of a Continuous Density Gradient of Immobilized Probes for Controlling the Stringency of DNA Hybridization." Thesis, 2010. http://hdl.handle.net/1807/25878.

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A new format for microfluidic based DNA biosensors is presented in which the biorecognition element (single stranded DNA probes) is immobilized as a continuous density gradient of probes along the length of a microfluidic channel instead of a standard array format commonly used in microarray technologies or DNA based biosensors. The development of continuous density gradients of immobilized probe was achieved by electrokinetically subjecting probes that were terminated with an appropriate functional group for a surface coupling reaction to increasing convective velocity along the length of the

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23

Lim, Ying. "Surface Templating Using a Photolabile Terpolymer to Construct Mixed Films of Oligomers and Oligonucleotides for DNA Biosensor Development." Thesis, 2010. http://hdl.handle.net/1807/26289.

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A photolabile terpolymer containing 6-nitroveratyloxycarbonyl (NVOC) protected amine, epoxy and trimethoxysilyl functionality in 1:3:2 monomer ratio was synthesized to template glass surfaces for specific site directed coupling of non-probe oligomers and probe oligonucleotides. Non-probe oligomers were introduced to the surface to control the environment of the probes by reducing probe-to-probe and probe-to-surface interactions. The trimethoxysilyl group served as the anchoring site for the terpolymer to be covalently bound to glass and silicon wafers. Amine terminated non-probe oligomers were

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24

Jakubec, Dávid. "Interakční preference v komplexech protein - DNA." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-331788.

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Interaction preferences in protein - DNA complexes Dávid Jakubec Abstract Interactions of proteins with DNA lie at the basis of many fundamental bio- logical processes. Despite ongoing efforts, the rules governing the recognition of specific nucleic acid sequences have still not been universally elucidated. In this work, I attempt to explore the recognition process by splitting the intricate network of contacts at the protein - DNA interface into contribu- tions of individual amino acid - nucleotide pairs. These pairs are extracted from existing high-resolution structures of protein - DNA comp

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25

Wong, April Ka Yee. "A Mixed Biosensing Film Composed of Oligonucleotides and Poly (2-hydroxyethyl methacrylate) Brushes to Enhance Selectivity for Detection of Single Nucleotide Polymorphisms." Thesis, 2010. http://hdl.handle.net/1807/24914.

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This work has explored the capability of a mixed film composed of oligonucleotides and oligomers to improve the selectivity for the detection of fully complementary oligonucleotide targets in comparison to partially complementary targets which have one and three base-pair mismatched sites. The intention was to introduce a “matrix isolation” effect on oligonucleotide probe molecules by surrounding the probes with oligomers, thereby reducing oligonucleotide-to-oligonucleotide and/or oligonucleotide-to-surface interactions. This resulted in a more homogeneous environment for probes, thereby min

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26

Vinader, Victoria, Maria Sadiq, Mark H. Sutherland, et al. "Probing cytochrome P450-mediated activation with a truncated azinomycin analogue." 2014. http://hdl.handle.net/10454/9419.

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Yes<br>A deactivated alkene precursor (IC50=81 mu M) to the azinomycin epoxide natural product can be bioactivated by several cytochromes P450 (CYP) to generate antiproliferative metabolites with increased potency (IC50=1-30 mu M) in CHOwt cells. CYP1A1 and 3A4 were shown to generate exclusively the unnatural and the natural-configured azinomycin epoxide diastereoisomer respectively, while CYP1B1 produced both epoxides in a 3:1 mixture. The antiproliferative activity is linked to DNA damage as demonstrated using the comet assay.

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27

Anuradha, Valiya Kambrath. "Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism." Thesis, 2015. http://hdl.handle.net/1805/7942.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The Cre/loxP system is a tool for targeted recombination of DNA. For applying Cre recombinase-mediated genome modifications, there is a requirement for reliable, high-fidelity, and specific transgenic expression of the Cre recombinase. This study focuses on the reliability of different bone cell specific Cre models in the Cre/loxP system. In this study, DMP1-Cre transgenic mouse which has a transgene driven by DMP1 promotor that allows Cre-expression only in late stage osteoblasts and osteocytes was used. Ctsk-Cre mouse with a driven

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28

Monteiro, Luís Pedro Gomes. "Development of new anticancer metallodrugs." Master's thesis, 2019. http://hdl.handle.net/10773/28462.

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The success of chemotherapy has been achieved with low molecular weight drugs that have been shown to destroy cancer cells or to control their proliferation. However, there are several side effects associated with the use of many of these drugs, mainly due to the fact that they do not have selectivity, acting on both tumor and non-tumor cells. The use of coordinating compounds (metallo-pharmaceuticals) for anticancer therapy began with the use of platinum compounds, which, despite their well-known severe limitations, are still widely used. These disadvantages led to the need to explore new met

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29

Walton, Joseph. "Spectroscopic Investigation into Minor Groove Binders Designed to Selectively Target DNA Sequences." 2015. http://scholarworks.gsu.edu/chemistry_theses/82.

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Recently, there has been increasing focus toward the development of small molecules designed to target a specific sequences of double stranded DNA for therapeutic purposes1. Minor groove binding compounds have been shown to be capable of selectivity target GC sites in AT tract DNA2. In this research, binding selectivity was investigated using absorption, fluorescence and circular dichroic properties of selected DB minor groove binders in the presence of two unique DNA sequences. Further insight was gained by comparing the electrostatic potential maps and optimized structures of the compounds o

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30

Chou, Yu-Ching, and 周育晴. "Development of Photoactivated Nitrogen Mustard Anticancer Prodrug Aiming to Selectively Alkylate DNA." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/pnk786.

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碩士<br>國立臺灣大學<br>化學研究所<br>106<br>Development of highly selective anticancer drugs toward tumor cells in order to resolve the severe side effects caused by chemotherapeutic drugs is a primary goal for many research groups. The thesis is aimed to develop a photoactived anticancer prodrug. Incorporation of the aniline mustard, a clinical DNA alkylator, as well as electrophilic pyridinium to the dithienylethene (DTE) core was achieved by multistep synthesis to afford Py-F6DTE-Mus-c and NAEPy-F6DTE-Mus-c. Development of highly selective anticancer drugs toward tumor cells in order to resolve the sev

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31

Feresin, Emiliano [Verfasser]. "Methods to selectively introduce radicals into DNA : an EPR spectroscopic study / von Emiliano Feresin." 2005. http://d-nb.info/974448834/34.

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32

Chen, Chien-Han, and 陳建漢. "Development of Credible Molecular Probes to Identify Pregnenolone-Binding Proteins and Site-Selectively Alkylate G-Quadruplex DNA." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/86330457034233765253.

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博士<br>國立臺灣大學<br>化學研究所<br>104<br>The work presented here consists of two parts: Section I describes that pregnenolone (P5) was equipped with benzophenone photoreactive group and biotin tag at C7 position in ether linkage to explore P5-binding proteins in the stage of embryonic development of the zebrafish. Various spacer lengths and orientations of P5-photoaffinity probes had been employed to investigate the influences on the activity of in vitro tubulin polymerization. With the preservation of the biological functions as P5, P5-NBPN was used to label P5-binding proteins from zebrafish embryo l

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33

Arambula, Jonathan. "A stacked intercalator approach to selectively target mismatches within CTG and CUG trinucleotide repeats : aromatic stacking of naphthoyl modified cytosines within PNA DNA duplexes /." 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3363126.

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Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.<br>Source: Dissertation Abstracts International, Volume: 70-06, Section: B, page: 3507. Adviser: Steven C. Zimmerman. Includes bibliographical references. Available on microfilm from Pro Quest Information and Learning.

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