Log in

Relevant bibliographies by topics / DNA Transferase / Dissertations / Theses

To see the other types of publications on this topic, follow the link: DNA Transferase.

Dissertations / Theses on the topic 'DNA Transferase'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 September 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 41 dissertations / theses for your research on the topic 'DNA Transferase.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Khan, Zeenatul. "Adenosine diphosphoribosyl transferase in granulocyte-monocyte differentiation." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255772.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Jeffery, Jinny. "A study of the structure and function of a fragment of the Ada protein from E.coli B." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337062.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Lima, Monica Fernandes Rosa de. "Clonagem e caracterização parcial de cDNA de glândula salivar de Boophilus microplus (Acari:Ixodidae) similar a glutationa s-transferase." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2001. http://hdl.handle.net/10183/3089.

Full text

Abstract:

O carrapato Boophilus microplus é um ectoparasita hematófago de bovino que causa sérias perdas econômicas. Estudos para o desenvolvimento de formas alternativas de controle do carrapato tem sido realizados para diminuir ou substituir a aplicação de agentes químicos, que contaminam o ambiente, os derivados da carne, além dos problemas de resistência das gerações de carrapatos aos acaricidas. As vacinas são uma forma alternativa de controle do carrapato. As enzimas glutationa S-transferase (GSTs) são alvo potencial para intervenção imunológica contra alguns parasitas. Este trabalho teve como obj

APA, Harvard, Vancouver, ISO, and other styles

4

KOJIMA, KIYOHIDE, HIROMU NAKAMURA, and SHONEN YOSHIDA. "Occurrence of a Terminal Deoxynucleotidyl Transferase-Like Activity in N-2-Fluorenylacetamide-treated Rat Liver." Nagoya University School of Medicine, 1985. http://hdl.handle.net/2237/17476.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Becker, Eric Christian. "Recognition of oriT at the termination of conjugal transfer by MobA, the R1162 DNA strand transferase." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3077405.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Rusquet, Régine. "Expression de la dna ligase et de la terminal deoxynucleotidyl transferase dans les leucemies myeloides et lymphoides humaines." Rennes 1, 1986. http://www.theses.fr/1986REN10044.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Kurtovic, Sanela. "Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis." Doctoral thesis, Uppsala University, Department of Biochemistry and Organic Chemistry, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8718.

Full text

Abstract:

<p>Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. Furthermore, altering enzyme function also affords insight into how enzymes work and how natural evolution operates. </p><p>Previous investigations have explored catalytic properties in the directed evolution of mutant libraries with high sequence variation. Before this study was initiated, funct

APA, Harvard, Vancouver, ISO, and other styles

8

Barberino, Willian Marcel [UNESP]. "Polimorfismos GSTM1, GSTT1 e GSTP1 da enzima Glutationa S-transferase como fatores moduladores do fenótipo na anemia falciforme." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/122180.

Full text

Abstract:

Made available in DSpace on 2015-04-09T12:28:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-28Bitstream added on 2015-04-09T12:47:33Z : No. of bitstreams: 1 000811540.pdf: 772912 bytes, checksum: 9fe40489ccb3153a59c8440d6126a541 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A anemia falciforme (AF) é uma anemia hemolítica hereditária que acarreta ao portador manifestações clínicas complexas e diversificadas. Na AF o estresse oxidativo é um dos fatores que interferem no fenótipo do

APA, Harvard, Vancouver, ISO, and other styles

9

Barberino, Willian Marcel. "Polimorfismos GSTM1, GSTT1 e GSTP1 da enzima Glutationa S-transferase como fatores moduladores do fenótipo na anemia falciforme /." São José do Rio Preto, 2014. http://hdl.handle.net/11449/122180.

Full text

Abstract:

Orientador: Claudia Regina Bonini Domingos<br>Banca: Gustavo Orlando Bonilla Rodriguez<br>Banca: Nicola Amanda Conran Zorzetto<br>Resumo: A anemia falciforme (AF) é uma anemia hemolítica hereditária que acarreta ao portador manifestações clínicas complexas e diversificadas. Na AF o estresse oxidativo é um dos fatores que interferem no fenótipo do portador, uma vez que influencia nos processos de vaso-oclusão aumentando as propriedades adesivas dos eritrócitos, leucócitos e plaquetas ao endotélio. Durante a transformação do eritrócito discóide com hemoglobina (Hb) S em eritrócito afoiçado, dent

APA, Harvard, Vancouver, ISO, and other styles

10

Melzer, Susanne, Christian Sonnendecker, Christina Föllner, and Wolfgang Zimmermann. "Stepwise error-prone PCR and DNA shuffling changed the pH activity range and product specificity of the cyclodextrin glucanotransferase from an alkaliphilic Bacillus sp." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-172353.

Full text

Abstract:

Cyclodextrin glucanotransferase (EC 2.4.1.19) from the alkaliphilic Bacillus sp. G-825-6 converts starch mainly to c-cyclodextrin (CD8). A combination of error-prone PCR and DNA shuffling was used to obtain variants of this enzyme with higher product specificity for CD8 and a broad pH activity range. The variant S54 with seven amino acid substitutions showed a 1.2-fold increase in CD8-synthesizing activity and the product ratio of CD7:CD8 was shifted to 1:7 compared to 1:3 of the wild-type enzyme. Nine amino acid substitutions of the cyclodextrin glucanotransferase were performed to generate t

APA, Harvard, Vancouver, ISO, and other styles

11

Mousseau, Mireille. "Étude des mécanismes moléculaires de chimiorésistance intrinsèque des tumeurs cérébrales humaines." Grenoble 1, 1992. http://www.theses.fr/1992GRE10186.

Full text

Abstract:

La chimiothérapie a une faible efficacité sur les tumeurs cérébrales humaines (taux de réponse objective allant de 13 a 33%). Nous avons étudié les mécanismes moléculaires de chimiorésistance intrinsèque sur une série de 66 tumeurs cérébrales humaines comportant 31 gliomes (1 gangliogliome grade 1, 9 astrocytomes grade 2 et 10 grade 3, 11 gliomes grade 4), 18 méningiomes, 12 métastases cérébrales (de 2 cancers bronchiques épidermoïdes; de 8 adénocarcinomes du sein (3 cas), du poumon (2 cas), d'origine indéterminée (2 cas) et du colon (1 cas); d'1 sarcome d'Ewing; d'1 cancer bronchique peu diff

APA, Harvard, Vancouver, ISO, and other styles

12

Moreno, Daniel Antunes. "Estudo da Expressão dos Genes DNMT1, DNMT3A, DNMT3B, MGMT e Efeitos da Zebularina em Glioblastoma." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-102215/.

Full text

Abstract:

Os gliomas são tumores que surgem a partir de células da glia e são considerados os mais comuns do sistema nervoso central. São subdivididos em quatro grupos: astrocitoma pilocítico (grau I), astrocitoma difuso (grau II), astrocitoma anaplásico (grau III) e glioblastoma (grau IV ou GBM). Entre esses, o GBM é o tumor mais agressivo e mais freqüente. Apesar de ser encontrado em qualquer faixa etária, esse tumor é raro em crianças. Atualmente a cirurgia seguida de radioterapia e quimioterapia com temozolomida (TMZ) tem sido utilizado como protocolo de tratamento padrão para a maioria dos p

APA, Harvard, Vancouver, ISO, and other styles

13

Modén, Olof. "Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity." Doctoral thesis, Uppsala universitet, Biokemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167332.

Full text

Abstract:

Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. By screening a DNA shuffling library, five recombined segments were identified that were conserved among the most active mutants. Mutational analysis confirmed the importance of these short segments as their insertion into low-active GSTs introduced higher azathioprine activity. Besides, H-site mutagenesis led to decreased azathioprine activity when the targeted po

APA, Harvard, Vancouver, ISO, and other styles

14

Sundberg, Kathrin. "Carcinogenic polycyclic aromatic hydrocarbons : role of human glutathione transferases in conjugate formation and DNA protection /." Stockholm : [Karolinska Univ. Press], 2001. http://diss.kib.ki.se/2001/91-7349-046-6/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Bauer, Theresa [Verfasser], and Peter [Akademischer Betreuer] Graumann. "Investigation of pLS20 mediated conjugative DNA transfer in the Gram positive bacterium Bacillus subtilis = Untersuchung des pLS20 vermittelten, konjugativen DNA-Transfers in Bacillus subtilis." Freiburg : Universität, 2011. http://d-nb.info/1123459010/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Saidi, Selma. "Optimisation des transferts de données sur systèmes multiprocesseurs sur puce." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00875582.

Full text

Abstract:

Les systèmes multiprocesseurs sur puce, tel que le processeur CELL ou plus récemment Platform 2012, sont des architectures multicœurs hétérogènes constitués d'un processeur host et d'une fabric de calcul qui consiste en plusieurs petits cœurs dont le rôle est d'agir comme un accélérateur programmable. Les parties parallélisable d'une application, qui initialement est supposé etre executé par le host, et dont le calcul est intensif sont envoyés a la fabric multicœurs pour être exécutés. Ces applications sont en général des applications qui manipulent des tableaux trés larges de données, ces don

APA, Harvard, Vancouver, ISO, and other styles

17

McLay, David W. "Developmental regulation and molecular nature of an activity in murine oocytes that transfers histones onto sperm DNA." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38235.

Full text

Abstract:

At fertilization, the remodelling of the sperm nucleus into the male pronucleus is critical for normal development. Morphological and functional changes to the nucleus are underpinned by biochemical changes in the chromatin composition, most notably the removal of sperm specific protamines and assembly of histones onto the paternal DNA. This exchange is controlled by oocyte factors, as exemplified in Xenopus by nucleoplasmin. Though mammalian factors remain unidentified, a functional assay based on antibodies recognizing core histones has been developed to test the activity in oocytes that tra

APA, Harvard, Vancouver, ISO, and other styles

18

Roten, Conrad Ambros. "I. Zum Mechanismus der Threonin Dehydratase Reaktion : Versuche mit Cyclopropylglycin und Oxiranylglycinen : <> Der stereochemische Verlauf der C- und DNA-Methyl-Transferasen /." Zürich, 1995. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11138.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

BOUCHEZ, DAVID. "L'adn transfere du plasmide ri d'agrobacterium rhizogenes : aspects structuraux et fonctionnels de quelques genes portes par le tr-dna du plasmide a agropine pria4." Paris 11, 1990. http://www.theses.fr/1990PA112084.

Full text

Abstract:

Le plasmide ri a agropine d'agrobacterium rhizogenes souche a4 porte deux regions t distinctes, donnant naissance au tl- et tr-dna. J'ai etudie sur le tr-dna la region responsable de la synthese des mannityl-opines dans les racines de hairy root. Apres avoir localise cette region par hybridation avec des sondes de pti, des insertions de tn5 ont ete obtenues. Certaines de ces insertions inactivent la synthese d'agropine dans les racines. La sequence nucleotidique complete des trois genes impliques dans la synthese des mannitylopines a ete etablie et comparee avec celles des genes homologues de

APA, Harvard, Vancouver, ISO, and other styles

20

Martins, Raquel Reis [UNESP]. "Hemograma, proteinograma e enzima gama-glutamil transferase de cães neonatos, do 3º ao 45º dia de vida, sob a ação da idade e da suplementação com luteína." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/89308.

Full text

Abstract:

Made available in DSpace on 2014-06-11T19:24:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2005Bitstream added on 2014-06-13T18:20:04Z : No. of bitstreams: 1 martins_rr_me_botfmvz.pdf: 204527 bytes, checksum: 7f0d1db649e68d4039c491433d3ef914 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>No nascimento, os cães estão extremamente susceptíveis às doenças infecciosas. Esta vulnerabilidade poderá elevar a taxa de mortalidade. Deste modo, um aumento da resposta imunológica, nesta fase, seria conveniente a fim de tornar estes animais mais resistentes. O objetivo deste trabalho foi estab

APA, Harvard, Vancouver, ISO, and other styles

21

Martins, Raquel Reis. "Hemograma, proteinograma e enzima gama-glutamil transferase de cães neonatos, do 3º ao 45º dia de vida, sob a ação da idade e da suplementação com luteína /." Botucatu : [s.n.], 2005. http://hdl.handle.net/11449/89308.

Full text

Abstract:

Orientador: Raimundo Sousa Lopes<br>Resumo: No nascimento, os cães estão extremamente susceptíveis às doenças infecciosas. Esta vulnerabilidade poderá elevar a taxa de mortalidade. Deste modo, um aumento da resposta imunológica, nesta fase, seria conveniente a fim de tornar estes animais mais resistentes. O objetivo deste trabalho foi estabelecer valores de referência para o hemograma e proteinograma, de dois grupos experimentais de cães neonatos SRD. Os animais foram avaliados semanalmente, do 3º até seu 45º dia de vida. O grupo que não recebeu nenhum tipo de tratamento foi considerado contro

APA, Harvard, Vancouver, ISO, and other styles

22

Topsoy, Kolukisa Serap. "Biochemical, Cytotoxic And Genotoxic Effects Of Aescin On Human Lymphocytes And Hl-60 Promyeloid Leukemia Cell Line." Phd thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606341/index.pdf.

Full text

Abstract:

Aescin is a mixture of several acidic triterpenoid saponin glycosides found in the extracts of the horse chestnut tree. Horse chestnut, Aesculus Hipoocastanum, is one of the 25 domestic species of Aesculus that are mostly large, ornamental shade trees. Although known to be poisonous, the nuts of the horse chestnut are used by Amerindians, after detoxification. Horse chestnuts are said to have several traditional medicinal usages including even cancer. In this study the biochemical, genotoxic, and cytotoxic effects of aescin was studied using isolated lymphocytes, whole blood lymphocytes and

APA, Harvard, Vancouver, ISO, and other styles

23

Han, Yi. "Functional analysis of glutathione and autophagy in response to oxidative stress." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112392/document.

Full text

Abstract:

Le H2O2 est reconnu comme un signal dans l’activation des mécanismes de défense en réponse à divers stress, et son accumulation est donc régulée étroitement par le système antioxydant des plantes. Puisque la signalisation par le H2O2 peut être transmise par des processus thiol-dépendants, le statut du glutathion pourrait jouer un rôle important. Le rôle de ce composé en tant que molécule antioxydante est bien établi; cependant, son importance en tant que signal reste à élucider. Afin d’étudier cette question, ce travail a utilisé un mutant, cat2, ayant un défaut dans son métabolisme du H2O2 pe

APA, Harvard, Vancouver, ISO, and other styles

24

Loiseau, Vincent. "Etude de transferts horizontaux de matériel génétique entre virus et animaux Characterization of a new case of XMLV (Bxv1) contamination in the human cell line Hep2 (clone 2B) Wide spectrum and high frequency of genomicstructural variation, including transposableelements, in large double-stranded DNA viruses." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL018.

Full text

Abstract:

Les transferts horizontaux (TH) d’ADN sont de plus en plus reconnus comme un phénomène important dans l’évolution des métazoaires. La grande majorité des TH entre animaux implique des éléments transposables (ET), séquences génomiques égoïstes capables de se déplacer par transposition dans le génome et générer ainsi de multiples copies. Si ces TH d’ET semblent avoir un rôle prépondérant dans l’évolution des métazoaires, les mécanismes sous-tendant ces TH restent mal connus. Un des mécanismes possibles implique les virus qui pourraient être des vecteurs d’ADN entre les hôtes qu’ils infectent. Ce

APA, Harvard, Vancouver, ISO, and other styles

25

Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.

Full text

Abstract:

L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2

APA, Harvard, Vancouver, ISO, and other styles

26

Cheng, Yin Hua, and 鄭尹華. "Cloning, Expression and Activity Assay of Wolbachia DNA Methyl Transferase." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/08280957221687420890.

Full text

Abstract:

碩士<br>國立彰化師範大學<br>生物學系<br>99<br>Wolbachia is one kind of obligated cellular symbiont belongs to alpha Proteobacteria, Rickettsiales and is widely found in insect and arthropod.This intracellular symbiont can cause many reproductive variation of its host,that including male killing, feminization , parthenogenesisand cytoplasmic incompatibility. So far, the causes of these phenomena were not cleard. Wolbachia may be caused methylation by the leafhopper genome., and determined the infected male offspring of the leaf hopper will development female characteristics. This study use the Callosobruchus

APA, Harvard, Vancouver, ISO, and other styles

27

Naia, Maria Beatriz Rebelo Pinto Freitas da. "Genetic Variability of DNMT genes - Role in Chronic Lymphocytic Leukaemia predisposition and prognosis." Master's thesis, 2018. http://hdl.handle.net/10316/82173.

Full text

Abstract:

Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>Background e objetivos – A leucemia linfocítica crónica (LLC) é uma neoplasia hematológica que afeta as células B maduras e alterações no perfil de metilação do DNA têm vindo a ser associadas com o seu desenvolvimento. A metilação do DNA é catalisada por DNA metiltransferases (DNMTs). As DNMT3A e DNMT3B são responsáveis pela metilação de novo tendo maior afinidade por DNA não metilado. A DNMT1 é responsável pela manutenção do perfil de metilação apresentando maior afinidade por DNA hemi-metilado. Além diss

APA, Harvard, Vancouver, ISO, and other styles

28

Sung, Min Woo 1980. "Mechanisms of Microbial DNA Sensing by the AIM2 Inflammasome and Structural Study of Polynucleotydyl Transferase1 (pnt1) from Arabidopsis Thaliana." Thesis, 2012. http://hdl.handle.net/1969.1/148379.

Full text

Abstract:

AIM2 (absence in melanoma 2) can sense foreign cytosolic double-stranded DNA (dsDNA) through the dsDNA binding HIN-200 domain at the C-terminus. Once dsDNA is bound to HIN-200 domain, AIM2 can activate the AIM2 inflammasome, resulting in maturation of pro-interleukin-1β by activation of caspase-1. To investigate the mechanism of DNA binding, HIN-200 domain of mouse AIM2 bound to 15bp, 18bp, 20bp and 30bp dsDNAs were purified and crystallized. Diffraction data for four different crystals were collected to about 4Å resolution. Interestingly, all the crystals were in the same cubic space group I2

APA, Harvard, Vancouver, ISO, and other styles

29

Feng, Yen-Po, and 馮彥博. "Expression and regulation of O-GlcNAc transferase in tumor cells responding to DNA damage." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/57419252802906624386.

Full text

Abstract:

碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>103<br>O-GlcNAcylation, one of the post-translational modifications of proteins, participates in diverse cellular mechanisms. Abnormal cellular O-GlcNAc levels may result in diseases such as diabetes and cancer. It is known that O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) play important roles in maintaining cellular O-GlcNAcylation homeostasis. OGT catalyzes O-linked glycosylation of proteins by transferring the monosaccharide, N-acetylglucosamine, onto hydroxyl groups of serine/threonine residues, while OGA reverses this modification. OGT has been shown to b

APA, Harvard, Vancouver, ISO, and other styles

30

Madhusoodanan, U. K. "Functional Analysis Of Unique Motifs In Dimeric EcoP151 DNA Methyltransferase." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/992.

Full text

Abstract:

Restriction endonucleases occur ubiquitously among bacteria, archaea and in viruses of certain unicellular algae, and they are usually accompanied by a modification enzyme of identical specificity; together, the two activities form a restriction-modification (R-M) system- the prokaryotic equivalent of an immune system. More than 3,800 R-M enzymes have been characterized so far and they manifest 262 unique recognition specificities. These enzymes represent the largest family of functionally related enzymes. Based on the number and organization of subunits, cofactor requirements, catalytic mecha

APA, Harvard, Vancouver, ISO, and other styles

31

Madhusoodanan, U. K. "Functional Analysis Of Unique Motifs In Dimeric EcoP151 DNA Methyltransferase." Thesis, 2009. http://hdl.handle.net/2005/992.

Full text

Abstract:

Restriction endonucleases occur ubiquitously among bacteria, archaea and in viruses of certain unicellular algae, and they are usually accompanied by a modification enzyme of identical specificity; together, the two activities form a restriction-modification (R-M) system- the prokaryotic equivalent of an immune system. More than 3,800 R-M enzymes have been characterized so far and they manifest 262 unique recognition specificities. These enzymes represent the largest family of functionally related enzymes. Based on the number and organization of subunits, cofactor requirements, catalytic mecha

APA, Harvard, Vancouver, ISO, and other styles

32

Huang, Mingqian. "Molecular and computational approaches to DNA evolution applied to the mammalian class mu glutathione transferase gene cluster /." 2003. http://wwwlib.umi.com/dissertations/fullcit/3062138.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Tjong, Vinalia. "On-chip Labeling via Surface Initiated Enzymatic Polymerization (SIEP) for Nucleic Acids Hybridization Detection." Diss., 2013. http://hdl.handle.net/10161/7152.

Full text

Abstract:

<p>Current techniques for nucleic acid analysis often involve extensive sample preparation that requires skilled personnel and multiple purification steps. In this dissertation, we introduce an on-chip, isothermal, post-hybridization labeling and signal amplification technique that can directly interrogate unmodified DNA and RNA samples on a microarray format, eliminating the need for microarray sample pre-processing. </p><p>We name this technique Surface Initiated Enzymatic Polymerization (SIEP), where we exploit the ability of a template independent DNA polymerase called Terminal Deoxynucleo

APA, Harvard, Vancouver, ISO, and other styles

34

Süße, Silke [Verfasser]. "Funktionelle Interaktionen zwischen Wildtyp-p53, Rad51 und Poly-ADP-Phosphoribosyl-Transferase bei der Kontrolle von DNA-Rekombinationsprozessen / vorgelegt von Silke Süße." 2004. http://d-nb.info/970153139/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Mao-Wen and 翁茂文. "Alleviation of benzo[a]pyrene diolepoxide-DNA damageand alternative splicing of MDM2 mRNA in human lung carcinoma by Glutathione S-transferase M2." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/39719478630855617963.

Full text

Abstract:

博士<br>中山醫學大學<br>醫學分子毒理學研究所<br>93<br>Cellular detoxification is important for the routine removal of environmental and dietary carcinogens. Glutathione S-transferases (GST) is major cellular phase II detoxification enzymes. In addition to full length MDM2 transcript, multiple spliced forms of MDM2 transcripts have been observed in human tumors and may contribute toward tumorigenesis. The collective results of Huei Lee, Ph.D and Jiunn-Liang Ko, Ph. D. have shown that the frequency of MDM2 splice variants in lung cancer patients (31 of 117; 26%) was significantly higher than that of nontumor pati

APA, Harvard, Vancouver, ISO, and other styles

36

Chia-Ying and 黃嘉瑩. "Study on expression of Glutathione S-transferase M2 gene in human lung cancer and alleviation of DNA damage exposed to benzo [a] pyrene." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/43679068660815575223.

Full text

Abstract:

碩士<br>中山醫學大學<br>醫學分子毒理學研究所<br>95<br>Glutathione S transferases(GSTs)are a family of phase II detoxification enzymes that catalyse the conjuation of glutatione(GSH)to a wide variety of endogenous and exogenous electrophilic compounds. In our previous studies, we found that the overexpression of GST M2 gene in H1355 cells prevented BPDE-mediated formation of DNA adducts. Furthermore, by using RT PCR and Real time-PCR, we found that the expression level of GST M2 was lower in lung cancer cells in comparison to normal lung cells. GST Pi expressed both in lung cancer cells and normal lung cells. Ho

APA, Harvard, Vancouver, ISO, and other styles

37

Wei-ChunCheng and 鄭維鈞. "The Roles of Cyclooxygenase-2 (COX-2) and DNA Methyl-transferase 3B (DNMT3B) Expression on the Index Colon Polyp to Correlate with High Risk Adenoma or Cancer Occurrence." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/6g9xw6.

Full text

Abstract:

碩士<br>國立成功大學<br>臨床醫學研究所碩士在職專班<br>103<br>The colorectal cancer is the third leading cause of cancer death and the first incidence cancer in Taiwan. Under nationwide colorectal cancer screening, in addition to colorectal cancer patients identified, many cases with colon polyps or adenomas were revealed. To optimize surveillance strategy after complete polypectomy, we used molecular markers cyclooxygenase (COX-2), as an important marker in inflammation and cancerization process, and DNA methyltransferase 3B (DNMT3B), as an important enzyme influencing DNA methylation, to see whether their express

APA, Harvard, Vancouver, ISO, and other styles

38

Lin, Yu-chun, and 林育君. "Molecular Epidemiologic Study on Association with Arsenic-induced Skin Cancer for Genetic Polymorphisms of Glutathione S-transferase and DNA Repair Gene in the Endemic Area of Blackfoot Disease in Taiwan." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/54521114898289916803.

Full text

Abstract:

碩士<br>國立臺灣大學<br>流行病學研究所<br>88<br>Residents in the arseniasis-endenmic area in southwestern Taiwan has started to use tap water sine 1970, the cancer mortality of them remains higher than the general population in Taiwan. The high incidence of arsenic-induced skin cancer suggests the existence of the effects of genetic damage induced by arsenic exposure in early years. The prevalence of skin cancer in this area is about 5.9 per 1,000, the low prevalence suggests the individual variation in susceptibility to arsenic- induced cancer. The specific aim of this study is to examine the association wi

APA, Harvard, Vancouver, ISO, and other styles

39

Wheelhouse, Richard T., Michael C. Bibby, Anna Nicolaou, and Dimitrios Pletsas. "Polar, Functionalized Guanine-O6 Derivatives Resistant to Repair by O6-Alkylguanine-DNA Alkyltransferase: Implications for the Design of DNA-modifying Drugs." 2009. http://hdl.handle.net/10454/3168.

Full text

Abstract:

No<br>The protein O6-alkylguanine-DNA alkyltransferase (Atase) is responsible for the repair of DNA lesions generated by several clinically important anti-cancer drugs; this is manifest as active resistance in those cancer cell lines proficient in Atase expression. Novel O6-substituted guanine analogues have been synthesized, bearing acidic, basic and hydrogen bonding functional groups. In contrast to existing O6-modified purine analogues, such as methyl or benzyl, the new compounds were found to resist repair by Atase even when tested at concentrations much higher than O6-benzylguanine, a wel

APA, Harvard, Vancouver, ISO, and other styles

40

Silva, Catarina Milheiro Soares da. "Elucidating Gata2 transcription facto role during DNA replication and epigenetic inheritance." Master's thesis, 2019. http://hdl.handle.net/10316/88010.

Full text

Abstract:

Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>A informação genética e epigenética, associada à definição de um padrão de expressão génica e à estrutura da cromatina, são responsáveis pela determinação da identidade celular. A manutenção da identidade e da linhagem celulares ocorrem durante o ciclo celular, uma vez que a fiel restauração da identidade de uma célula ou a sua diferenciação num tipo celular diferente, estão dependentes da conservação de marcas epigenéticas e dos padrões de expressão génica. Durante a fase S, a replicação do ADN e as alte

APA, Harvard, Vancouver, ISO, and other styles

41

Saha, Ankita. "Potential role of histone deacetylases in the development of the chick and murine retina." Thesis, 2014. http://hdl.handle.net/1805/4980.

Full text

Abstract:

Indiana University-Purdue University Indianapolis (IUPUI)<br>The epigenetic state of any cell is, in part, regulated by the interaction of DNA with nuclear histones. Histone tails can be modified in a number of ways that impact on the availability of DNA to interact with transcriptional complexes, including methylation, acetylation, phosphorylation, ubiquituination, and sumoylation. Histones are acetylated by a large family of enzymes, histone acetyl transferases (HATs), and deacetylated by the histone deacetylases (HDACs). Acetylated histones are generally considered markers of genomic region

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!