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Dissertations / Theses on the topic 'DNA translocation'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Reimann, Peter, Andreas Meyer, Thomas Töws, and Sebastian Getfert. "Modeling DNA-translocation through nanopores." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-179409.

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2

Sivanathan, Viknesh. "Regulation of DNA translocation by FtsK." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670159.

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3

Guy, Andrew T. "Molecular dynamics studies of DNA translocation through nanopores." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/354556/.

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4

Reimann, Peter, Andreas Meyer, Thomas Töws, and Sebastian Getfert. "Modeling DNA-translocation through nanopores: two case studies." Diffusion fundamentals 20 (2013) 6, S. 1, 2013. https://ul.qucosa.de/id/qucosa%3A13527.

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5

Diallo, Amy. "The DNA translocation apparatus involved in Streptococcus Pneumoniae transformation." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066334/document.

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La transformation naturelle bactérienne permet aux micro-organismes d'échanger des informations génétiques pour promouvoir leurs réponses adaptatives pour faire face aux changements environnementaux. De l'ADN extracellulaire est incorporé et recombiné au génome de l'hôte. Ce processus augmente la plasticité des bactéries. Chez S. pneumoniae, un pathogène majeur chez l'Homme engendrant des infections pouvant être mortelles, la transformation bactérienne accentue la transmission de gènes de résistance aux antibiotiques. Chez les bactéries à Gram positif, l'opéron comF encode l'expression de deux
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6

Diallo, Amy. "The DNA translocation apparatus involved in Streptococcus Pneumoniae transformation." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066334.pdf.

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La transformation naturelle bactérienne permet aux micro-organismes d'échanger des informations génétiques pour promouvoir leurs réponses adaptatives pour faire face aux changements environnementaux. De l'ADN extracellulaire est incorporé et recombiné au génome de l'hôte. Ce processus augmente la plasticité des bactéries. Chez S. pneumoniae, un pathogène majeur chez l'Homme engendrant des infections pouvant être mortelles, la transformation bactérienne accentue la transmission de gènes de résistance aux antibiotiques. Chez les bactéries à Gram positif, l'opéron comF encode l'expression de deux
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7

Barder, Simen Eidsmo. "Molecular Dynamics Simulations of DNA Translocation through a biological Nanopore." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for konstruksjonsteknikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-19428.

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Experimental and simulation studies of nucleic acid transport through nanosized channels, both biological and synthetic, has become a rapidly growing research area over the last decade. While the utilization of the alpha-hemolysin channel as a sequencing device is soon to be realized, other biological nanochannels may hold advantages that are yet unknown. Motivated by this, the first reported molecular dynamics simulations of DNA translocation through a connexon 26 channel were accomplished, for single-strandeed DNA with a length of 24 nucleotides and with a sequence containing only adenine, c
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8

Gupta, Cherry. "DNA Translocation and Cell Electroporation in Micro and Nanofluidic Devices." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1448318827.

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9

Manara, Richard. "Free energy calculations of DNA translocation through protein nanopores and nanopore design for DNA sequencing." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/374791/.

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DNA sequencing has vastly opened up the world of molecular biology, leading to new areas of interest, especially in medical research. Unfortunately the methods of DNA sequencing have only ever seen gradual improvements, as Sanger sequencing is still very much the norm despite its high cost and slow speed. Nanopores present an exciting opportunity for DNA sequencing, however, despite the concept being presented in 1996 several problems have prevented the creation of a publicly available sequencing device. The two main focuses of research into nanopores so far have been improving the resolution
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10

Kesselheim, Stefan [Verfasser], and Christian [Akademischer Betreuer] Holm. "Simulations of DNA translocation through nanopores / Stefan Kesselheim. Betreuer: Christian Holm." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2015. http://d-nb.info/107487112X/34.

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11

Knust, Sebastian [Verfasser]. "Optical tweezers for DNA translocation and cell elasticity experiments / Sebastian Knust." Bielefeld : Universitätsbibliothek Bielefeld, 2020. http://d-nb.info/1213025605/34.

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12

Davies, Graham Peter. "Motifs in the HsdR subunit of EcoKI necessary for ATP-dependent DNA translocation and DNA cleavage." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/13586.

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The type I restriction enzyme <i>Eco</i>KI specifies DNA methyltransferase, ATPase, DNA translocase and endonuclease activities. One subunit (HsdR) of the oligomeric enzyme contributes to those activities essential for restriction. These activities are thought to involve ATP-dependent DNA translocation and DNA cleavage. Analyses of recently predicted amino acid sequences of known and putative type I restriction endonucleases indicates conservation of eight amino acid motifs in the HsdR subunit. Seven are characteristics of the DEAD-box family of proteins that comprise known, or putative, helic
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13

McClelland, Sarah Elizabeth. "Translocation on linear and circular DNA by the type I restriction enzymes." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274834.

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14

Yunnan, Jiang. "Testing the occurrence of forward hyper-translocation during the promoter escape transition / Jiang Yunnan." Connect to online version, 2009. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2009/381.pdf.

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15

Szuttor, Kai [Verfasser], and Christian [Akademischer Betreuer] Holm. "Modeling the translocation of DNA structures through nanopores / Kai Szuttor ; Betreuer: Christian Holm." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-117147.

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16

Sean-Fortin, David. "Highly Driven Polymer Translocation in the Presence of External Constraints: Simulations and Theory." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35803.

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DNA sequencing via nanopore translocation was a pipedream two decades ago. Today, biotech companies are releasing commercial devices. Yet many challenges still hover around the simple concept of threading a long DNA molecule through a small nanoscopic pore with the aim of extracting the DNA’s sequence along the process. In this thesis I use computer simulations to create what are in essence virtual pro- totypes for testing design ideas for the improvement of nanopore translocation devices. These ideas are based on the general concept of modifying the average shape of the initial DNA conformat
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17

Stephen, Susan. "mRNA, microtubules and motor proteins : investigations into mRNA translocation along nutritive tubes of an hemipteran insect." Thesis, University of Exeter, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312416.

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18

Zhekov, Ivailo. "Dissection of a functional interaction between the XerD recombinase and the DNA translocase FtsK." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572642.

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Successful bacterial circular chromosome segregation requires that any dimeric chromosomes, which arise by crossing over during homologous recombination, are converted to monomers. Resolution of dimers to monomers requires the action of the XerCD site-specific recombinase at dif in the chromosome replication terminus region. This reaction requires the DNA translocase, FtsK(C), which activates dimer resolution by catalysing an ATP hydrolysis-dependent switch in the catalytic state of the nucleoprotein recombination complex. We show that a 62-amino-acid fragment of FtsK(C) interacts directly wit
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19

Vlassarev, Dimitar. "DNA Characterization with Solid-State Nanopores and Combined Carbon Nanotube across Solid-State Nanopore Sensors." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10310.

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A DNA molecule passing through a nanopore in a liner and sequential fashion allows for unprecedented interrogation of the polymer. Adding transverse electrodes that are comparable in size and sensitive to the DNA molecule, can further the attempts to rapidly sequence DNA. Carbon nanotubes are comparable in size and interact strongly with the DNA molecule. This makes them an excellent choice for integration with nanopores. Only the section of the carbon nanotube in immediate proximity to the nanopore should be sensitive to the DNA molecules. Atomic layer deposition of metal-oxides passivates th
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20

Thakur, Shreyasi. "Développement des méthodes de molécule unique pour la détection simultanée des interactions protéine-ADN et leur application à l'étude du mécanisme de translocation de SpoIIIE." Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON1T008.

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Le transfert d'ADN chez les bactéries est un processus essentiel dans la ségrégation des chromosomes lors de la progression du cycle cellulaire et de nombreuses protéines sont impliquées dans ce processus. Parmi elles, on trouve la famille des protéines SpoIIIE / FtsK, et différentes fonctions leur ont été attribuées. SpoIIIE a été identifiée comme étant essentielle a la sporulation chez Bacillus subtilis. Au cours de la sporulation, un septum de division asymétrique se développe à proximité d'un pôle de la cellule et divise la cellule en deux compartiments : la préspore et la cellule mère. Sp
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21

Zeyl, Clifford. "Sex, parasitic DNA and adaptation in experimental populations of Saccharomyces cerevisiae and Chlamydomonas reinhardtii." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40475.

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The widespread occurrence among eukaryotes of sex and of mobile DNA sequences requires an evolutionary explanation, since both appear to reduce individual fitness. Both phenomena have been hypothesized to provide fitness advantages to populations, but such explanations require rather than explain the initial establishment of mobile elements and genes for sex. Genes encoding sexuality may invade asexual populations as molecular parasites, whose success then allows mobile elements to spread as parasites of sexual genomes. The prediction that mobile elements can invade only sexual populations was
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22

Noel, Pawan. "Discrete DNA integration events during Bridge-Induced Translocation generate partial chromosomal deletions and differential aneuploidy in Saccharomyces cerevisiae." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527456.

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23

Auger, Thomas. "Translocation de biopolymères à travers des pores naturels ou artificiels." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC128/document.

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La translocation de biopolymères à travers un nanopore intervient dans de nombreux processus biologiques et technologiques, comme le transport nucléocytoplasmique dans le pore nucléaire des cellules eucaryotes, la sécrétion de protéines, le séquençage rapide de l’ADN ou l’électrophorèse capillaire.Nous proposons une technique optique en molécule unique originale pour l’étude de la translocation de biopolymères à travers un nanopore basée sur l’effet Zero-Mode Waveguide. Nous nous sommes intéressés au passage d’ADN double-brin de plusieurs tailles, d’ADN simple-brin et d’ARN, entraînés par un f
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24

McCartney, Daniel Lawrence. "Investigating genome-wide transcriptional and methylomic consequences of a balanced t(1;11) translocation linked to major mental illness." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28873.

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Schizophrenia, bipolar disorder and major depressive disorder are devastating psychiatric conditions with a complex, overlapping genetic and environmental architecture. Previously, a family has been reported where a balanced chromosomal translocation between chromosomes 1 and 11 [t(1;11)] shows significant linkage to these disorders. This translocation transects three genes: Disrupted in schizophrenia- 1 (DISC1) on chromosome 1, a non-coding RNA, Disrupted in schizophrenia-2 (DISC2) antisense to DISC1, and a non-coding transcript, DISC1 fusion partner-1 (DISC1FP1) on chromosome 11, all of whic
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25

Monfouilloux, Sylvaine. "Etude de la structure et de l'évolution d'une région de translocations sous télomériques chez l'homme." Rouen, 1997. http://www.theses.fr/1997ROUES065.

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Les extrémités des chromosomes comportent le télomère puis la région sous télomérique. Ces deux domaines se distinguent des autres régions chromosomiques car ils évoluent par des échanges entre les chromosomes hétérologues. Le télomère est une structure spécialisée constituant la fin des chromosomes et indispensable à leur stabilité. Il joue un rôle important dans l'organisation spatiale des chromosomes en particulier dans l'agglutination des extrémités chromosomiques en périphérie nucléaire. La région sous télomérique, adjacente au télomère est très redondante entre les chromosomes hétérologu
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26

Okyay, Çağla. "Experimental study and molecular dynamics (MD) modeling of a nucleic acid in nano-confinement." Electronic Thesis or Diss., université Paris-Saclay, 2024. https://www.biblio.univ-evry.fr/theses/2024/2024UPASF063.pdf.

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La technologie des nanopores s'est imposée comme un outil puissant pour étudier le transport biomoléculaire, en particulier pour la translocation et le dézippage des molécules d'ADN. Les études expérimentales ont montré la capacité des nanopores de l'α-hémolysine (αHL) à distinguer différentes séquences et orientations d'ADN. Cependant, les résultats expérimentaux fournissent principalement des informations sur le courant bloqué et le temps de translocation, laissant les détails au niveau moléculaire du processus de dézippage inexplorés. Bien que les simulations de dynamique moléculaire tout-a
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27

Heyns, I. C. "Mapping and restructuring of an Ae. kotschyi derived translocation segment in common wheat." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5172.

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Thesis (PhD (Genetics))--University of Stellenbosch, 2010.<br>Includes bibliography.<br>ENGLISH ABSTRACT: The wild relatives are an important source of new genes for the genetic improvement of wheat. At Stellenbosch University the leaf and stripe rust resistance genes Lr54 and Yr37 were transferred from Aegilops kotschyi to chromosome 2DL of wheat. In an attempt to reduce the size of the whole-arm translocation on which the resistance genes occur, homoeologous pairing was induced between the wheat and corresponding Ae. kotschyi chromatin. The purpose of this study was to: (i) Evaluate th
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28

Puthiyaveetil, Abdulkader Abdul Gafoor. "Altered Kinetics of Non-Homologous End Joining Mediated DNA Repair in Mouse Models of Aging and Leukemia." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77233.

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DNA encodes the genetic instructions for the development and function of organisms and hence maintaining genomic integrity is essential for the propagation of life. However, DNA molecules are under constant threat of metabolic and environmental insults resulting in DNA damages including DNA double strand breaks (DSB), which are considered as a serious threat to cell survival. The majority of these DSB are repaired by Non-homologous end joining (NHEJ). Unrepaired DSB can lead to genomic instability resulting in cell cycle arrest, apoptosis, and mutations. Thus, delineating this DNA repair proce
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29

Besprozvannaya, Marina. "From DNA sequence recognition to directional chromosome segregation: Information transfer in the translocase protein SpoIIIE." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11373.

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Faithful chromosome segregation is essential for all living organisms. Bacterial chromosome segregation utilizes highly conserved directional SpoIIIE/FtsK translocases to move large DNA molecules between spatially separated compartments. These translocases employ an accessory DNA-interacting domain (gamma) that dictates the direction of DNA transport by recognizing specific DNA sequences. To date it remains unclear how these translocases use DNA sequence information as a trigger to expend chemical energy (ATP turnover) and thereby power mechanical work (DNA movement). In this thesis, I underto
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30

Taylor, James Edward Nathan. "Biochemical and biophysical characterisation of the genetically engineered Type I restriction-modification system, EcoR124I NT." Thesis, University of Portsmouth, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424193.

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The EcoR124INT restriction-modification (R-M) system contains the genes HsdS3, HsdM and HsdR. S3 encodes the N-terminal domain of the wild-type S subunit and has been shown to dimerise in solution (Smith et al., 1998). Following purification of the subunits of the EcoR124INT R-M system, complexes of the methyltransferase S3/M and restriction endonuclease S3/M/R were formed and shown to have activity in vitro, methylating and hydrolysing a symmetrical DNA recognition sequence, respectively. The DNA mimic OCR (overcome classical restriction) protein inhibited the methyltransferase activity in vi
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31

Hayes, Janelle A. "The Mechanism and Regulation of Bacteriophage DNA Packaging Motors." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1049.

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Many double-stranded DNA viruses use a packaging motor during maturation to recognize and transport genetic material into the capsid. In terminase motors, the TerS complex recognizes DNA, while the TerL motor packages the DNA into the capsid shell. Although there are several models for DNA recognition and translocation, how the motor components assemble and power DNA translocation is unknown. Using the thermophilic P74-26 bacteriophage model system, we discover that TerL uses a trans-activated ATP hydrolysis mechanism. Additionally, we identify critical residues for TerL ATP hydrolysis and DNA
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32

Qiao, Le. "Theoretical Study of Voltage-driven Capture and Translocation Through a Nanopore : From Particles to Long Flexible Polymers." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42250.

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Voltage-driven translocation, the core concept of nanopore sensing for biomolecules, has been extensively studied in silico and in vitro over the past two decades. However, the theories of analyte capture are still not complete due to the complex dynamics resulting from the coupling of multiple physical processes such as di usion, electrophoresis, and electroosmotic flow. In this thesis, I build and design translocation simulations for analytes ranging from point-like particles to rod-like molecules and long flexible polymers. The primary goal is to test, clarify and complete the existing cap
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33

Lee, Se Il. "Statistical thermodynamics of virus assembly." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33900.

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Experiments show that MgSO4 salt has a non-monotonic effect as a function of MgSO4 concentration on the ejection of DNA from bacteriophage lambda. There is a concentration, N0, at which the minimum amount of DNA is ejected. At lower or higher concentrations, more DNA is ejected. We propose that this non-monotonic behavior is due to the overcharging of DNA at high concentration of Mg⁺² counterions. As the Mg⁺² concentration increases from zero, the net charge of ejected DNA changes its sign from negative to positive. N0 corresponds to the concentration at which DNA is neutral. Our theory fits
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34

Gelot, Camille. "Rôle du complexe de cohésion sur la ligature d'extrémités d'ADN non homologues et la stabilité du génome." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066300/document.

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Au cours de la réplication, la réparation des cassures double brin (CDB) par recombinaison homologue (RH), basée sur la synthèse d’ADN à partir de la chromatide sœur, permet le maintien de la stabilité du génome. La religature d’extrémités (EJ) éloignées de CDB peut quant à elle générer des réarrangements menaçant son intégrité. Nous avons étudié le mécanisme de réparation par EJ en fonction de la distance séparant deux cassures double brin. En utilisant des substrats intra-chromosomiques permettant la mesure de l’efficacité et de la fidélité du EJ après ligature d’extrémités éloignées ou prox
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35

Soto-Calderon, Ivan D. "Evolution of Nuclear Integrations of the Mitochondrial Genome in Great Apes and their Potential as Molecular Markers." ScholarWorks@UNO, 2012. http://scholarworks.uno.edu/td/1510.

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The mitochondrial control region (MCR) has played an important role as a population genetic marker in many taxa but sequencing of complete eukaryotic genomes has revealed that nuclear integrations of mitochondrial DNA (numts) are abundant and widespread across many taxa. If left undetected, numts can inflate mitochondrial diversity and mislead interpretation of phylogenetic relationships. Comparative analyses of complete genomes in humans, orangutans and chimpanzees, and preliminary studies in gorillas have revealed high numt prevalence in great apes, but rigorous comparative analyses across t
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36

Britton, Sébastien. "Les protéines de jonction d'extrémités non homologues : nouvelles fonctions et connexions." Toulouse 3, 2009. http://www.theses.fr/2009TOU30143.

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Les Cassures Double-Brin de l'ADN (CDB) sont des lésions particulièrement toxiques dans les cellules humaines. Cette toxicité est exploitée pour tuer les cellules tumorales par radiothérapie. Chez l'homme, la voie majeure de réparation des CDB est la Jonction d'Extrémités Non-Homologues (NHEJ). Les protéines centrales de la NHEJ appartiennent à deux complexes : (i) le complexe DNA-PK qui assure la reconnaissance des CDB, composé de KU et de la sous-unité catalytique DNA-PKcs qui possède une activité sérine/thréonine kinase ; (ii) le complexe de ligature permettant la religature finale des deux
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37

Barrios, pérez María. "Design and computer simulations of 2D MeX2 solid-state nanopores for DNA and protein detection analysis." Thesis, Bourgogne Franche-Comté, 2020. http://www.theses.fr/2020UBFCK003.

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Les membranes nanoporeuses solides [en anglais, SSN (Solid State Nanopore)] sont devenues des dispositifs polyvalents pour l'analyse des biomolécules. L'une des applications les plus prometteuses des SSN est le séquençage de l'ADN et des protéines avec un coût réduit et une vitesse d’exécution plus rapide que les méthodes actuelles de séquençage. Le séquençage par SSN est basé sur la mesure des variations de courant ionique observées quand unebiomolécule, dans un milieu électrolytique, est forcée de traverser de manière séquentielle un nanopore sous l’action d’une différence de potentiel élect
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38

Malouf, Gabriel. "Décryptage des changements épigénétiques impliqués dans la transition épithélio-mésenchymateuse et le cancer." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T037.

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La transition épithélio-Mésenchymateuse (TEM) est un processus de plasticité cellulaire qui existe dans le développement embryonnaire et qui permet la formation des tissus et organes. Dans la cancérogénèse, ce processus est réactivé par des facteurs de transcription dont l’action implique très probablement un remodelage de la chromatine. La cartographie exacte de ces changements épigénétiques est peu connue à l’échelle du génome entier, même si il y a eu quelques études antérieures explorant les changements de quelques loci de façon bien ciblée. Ce mémoire traite du remodelage épigénétique méd
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39

Stover, Rachyl-anne. "Description of the dietary breadth and overlap of the translocated Shark Bay rufous hare-wallaby (Lagorchestes hirsutus) and banded hare-wallaby (Lagostrophus fasciatus) using scat DNA." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2025. https://ro.ecu.edu.au/theses/2922.

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Conservation translocations are increasingly used worldwide to prevent extinctions and support ecological restoration projects. These translocations involve a lot of uncertainty, particularly when species are introduced to ecosystems where they have not previously coexisted. Many historical translocations in Australia and globally have failed due to insufficient baseline data and inadequate post-translocation monitoring. Contemporary translocations can aim to improve translocation outcomes by increasing baseline data collection and developing robust post-release monitoring for translocated spe
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40

Waugh, Matthew. "Interfacing Solid-State Nanopores with Gel Media to Slow DNA Translocations." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32774.

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One of the most crucial steps towards nanopore-based nucleic acid analysis is extending the dwell time of DNA molecules within the sensing region of the nanopore. I address this issue by interfacing solid-state nanopores with gel media, which sterically hinders translocating DNA molecules, increasing dwell times. Specifically, my experimental results focus on two reptation regimes: when the DNA molecule is flexible on the length scale of the gel pore, and when the DNA molecule is inflexible on the length scale of the gel pore. The first regime is achieved through the use of agarose gel and 5 k
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41

Naiel, Abdulbasit. "Study of acute myeloid leukaemia with known chromosomal translocations." Thesis, Brunel University, 2014. http://bura.brunel.ac.uk/handle/2438/9303.

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Acute myeloid leukaemia (“AML”) is a clonal disease characterised by increased, uncontrolled abnormal white blood cells and the accumulation of leukaemia immature cells in the bone marrow and bloodstream. Chromosomal rearrangements have been detected in almost half of AML cases. It has been proven that the chromosomal rearrangements constitute a marker for the diagnosis and prognosis of AML and have therapeutic consequences. The discovery of these rearrangements has led to a new World Health Organization (“WHO”) classification system. However, small regions of cryptic chromosomal rearrangement
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42

Nwachuku, Julia Nonyelum Lucille. "An investigation of peptide-based translocating systems and their potential for gene therapy." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341147.

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43

Papucci, Chiara. "Study of position effect as a mechanism arising from chromosomal translocations in leukaemia." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11583.

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The chromosomal translocation of t(14;18)(14q32;18q21) is a characteristic aberration of follicular lymphoma and Diffuse Large B cells lymphoma. By PCR, it was proved that the rearrangement of chromosomes 14 and 18 leads to an overexpression of BCL2, an anti-apoptotic protein, which is one of the factors responsible for the maturation of the diseases. The translocation involves the promoter region of IGH gene and the transcriptional unit of BCL2 gene. Previous studies carried out in Dr Tosi’s lab showed a looping out of the BCL2 gene from its chromosome territory in 15% of the nuclei analysed.
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Bustamante, José. "Synchronous Optical and Electrical Measurements of Single DNA Molecules Translocating Through a Solid-State Nanopore." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/31903.

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Nanopore sensors are emerging as a promising technology for single molecule analysis and polymer sequencing. Traditionally, measurements are taken by monitoring the ionic current through the nanopore, which gives information (e.g. size, shape, charge) about a molecule of interest while it is in the confined geometry of the nanopore. The dynamics of the molecule before the arrival to the nanopore, such as the capture dynamics, or molecular conformation prior to translocation, as well as clogging mechanisms and features of anomalous translocation events, are not assessed by the electrical measur
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Arnaoty, Ahmed. "Etude de l'expression de recombinases néogéniques dans le cancer colorectal." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR4012.

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Le phénomène dit de domestication moléculaire qui a été rapporté pour certains transposons à ADN a abouti à la formation de néogènes qui codent des protéines potentiellement impliquées dans la stabilité du génome de part une activité recombinase. L’objectif de ce travail est d’étudier l’expression de 23 recombinases néogéniques d’intérêt dérivées de transpsons à ADN dans une série de cancers colorectaux. Nous avons fabriqué de nouveaux anticorps performants pour l’étude en western blot et en immunofluorescence de l’expression du gène SETMAR qui code pour la protéine Metnase dans des lignées ca
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Xie, Yinghong. "MD simulations of bio-nano-system : controllable translocation and selective separation of single-stranded DNAs through a polarized CNT membrane /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39559026.

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謝迎洪 and Yinghong Xie. "MD simulations of bio-nano-system: controllable translocation and selective separation of single-stranded DNAs through a polarized CNT membrane." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39559026.

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48

Di, Giovanni Francesca 1985. "The impact of chromosome positioning in nuclear functions." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/458452.

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Chromatin is not randomly organized inside the eukaryotic nucleus in interphase. In budding yeast gene expression of some specific loci is affected by their positioning in the nucleus. Replication firing of early origins is also correlated to the position of the respective ARSs (Autonomously Replicating Sequences) in the nucleus. However, the relationship between nuclear positioning and DNA processes is not yet fully understood. To study the importance of chromosome positioning in nuclear processes and cell physiology, we use budding yeast strains carrying fused chromosomes, which are
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Jakobczyk, Hélène. "Rôles de RUNX1 dan la pathogenèse des leucémies aiguës lymphoblastiques à réarrangement ETV6-RUNX1." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B033.

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Les leucémies aiguës lymphoblastiques de la lignée B (LAL-B) sont les cancers pédiatriques les plus fréquents. Dans ce type de leucémie, l'une des anomalies génétiques les plus fréquentes est la translocation t(12 ;21) aboutissant à la protéine de fusion ETV6-RUNX1. Cette pathologie est décrite comme un modèle à deux « hits ». Le premier, se produit in utero et génère la protéine de fusion. Le second, correspond à l’acquisition d’anomalies génétiques après la naissance. Ces réarrangements génomiques aberrants ont été décrits comme provenant d’une activité anormale de la recombinasse RAG. Notre
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顏培峻. "Gate effect on translocation of DNA through a SiO2 nanopore." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/06464082967204439112.

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