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Dissertations / Theses on the topic 'DNA variation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Pandya, Arpita. "Human Y-chromosomal DNA variation." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298658.

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2

Bromham, Lindell. "Rate variation in DNA sequence evolution." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339362.

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3

Adur, Ashwin. "DNA copy number variation in autism." Connect to resource, 2009. http://hdl.handle.net/1811/37275.

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4

Hill, Catherine E. "Mitochondrial DNA variation in Island Southeast Asia." Thesis, University of Huddersfield, 2005. http://eprints.hud.ac.uk/id/eprint/22331/.

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It is known that Island Southeast Asia was colonised relatively early in the history of modem humans; however, it is still a matter of some debate as to whether the modem inhabitants of Island Southeast Asia are descended from these original inhabitants or are the result of some later migration. Currently, the prevailing theory in both archaeology and linguistics is that the modem inhabitants of Island Southeast Asia are largely descended from an agricultural people who originated in China and Taiwan around 6,000 years ago. From there they are thought to have migrated through the Philippines a

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5

Meng, Anming. "DNA fingerprinting and minisatellite variation of swans." Thesis, University of Nottingham, 1990. http://eprints.nottingham.ac.uk/13889/.

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Genetic variation in natural populations of four species of swans (Cygnus bewickii, Cygnus olor, Cygnus buccinator and Cygnus cygnus) has been investigated by examining minisatellite loci using human DNA fingerprinting probes pSPT19.6 and pSPT18.15. It has been found that swan minisatellites are highly variable. However, the degree of variation depends on the population structure and species. Bewick's Swans at Slimbridge have the highest degree of minisatellite variation, Whooper Swans at Caerlaverock come second, and then Mute Swans, and Trumpeter Swans in Montana. Comparative study of DNA fi

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6

Saunders, Nigel John. "Bacterial phase variation associated with repetitive DNA." Thesis, Open University, 1999. http://oro.open.ac.uk/57999/.

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Phase variation is mechanism of phenotypic switching used by many pathogenic bacterial species. This thesis describes work on three aspects of phase variation. Mathematical models are described which can be used to determine the rate of phase variation and subsequently the influence of variation rate and fitness differences associated with the altered phenotype on population structure. An approach to whole genome analysis has been developed which has been used to identify putative phase variable contingency genes in H. pylori, T. pallidum and N. meningitidis. This has identified many new conti

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7

Hide, Geoffrey. "Variation in repetitive DNA in African Trypanosomes." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/12083.

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8

Lundmark, Per Erik. "Genetic and Genomic Analysis of DNA Sequence Variation." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158486.

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The studies in this thesis describe the application of genotyping and allele specific expression analysis to genetic studies. The role of the gene NPC1 in Triglyceride metabolism was explored in mouse models and in humans on the population level in study I. NPC1 was found to affect hepatic triglyceride metabolism, and to be relevant for controlling serum triglyceride levels in mice and potentially in humans. In study II the utility of the HapMap CEU samples was investigated for tagSNP selection in six European populations. The HapMap CEU was found to be representative for tagSNP selection in a

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9

Crompton, Tom. "Mobile DNA and genetic variation in Drosophila melanogaster." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30330.

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Whilst it is commonly accepted that transposable elements can generate genetic variation, the significance of this for the maintenance and dissemination of such elements is controversial. Here long-term laboratory populations of Drosophila melanogaster, maintained at two discrete temperatures, are screened by Southern blotting for the patterns of insertion of several transposable elements (copia, mdg-2, mdg-4 and P). Consistent with a temperature-specific adaptive role for some insertions, several are apparently found at higher frequency in lines at one temperature. Further characterisation of

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10

Eng, Ken Khong. "Complete mitochondrial DNA genome variation in Peninsular Malaysia." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/7872/.

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The peopling of Southeast Asia has been vigorously debated over the past few decades by archaeologists, linguists and anthropologists, as well as evolutionary and population geneticists. Several ethnic minorities in the region, the Orang Asli groups (the Semang, Senoi and Aboriginal Malays) from Peninsular Malaysia, are widely thought of as “relicts” of human diversity in the ancient Sunda continent. However, mitochondrial DNA (mtDNA analysis of these groups has hitherto been restricted to a small number of populations and largely based on the mtDNA control region hypervariable segment I (HVS-

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11

Ramsfield, Tod. "Variation in the mitochondrial DNA of Chondrostereum purpureum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24226.pdf.

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12

Ulbert, Sebastian. "DNA repair and antigenic variation in Trypanosoma brucei." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/68203.

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13

Bell, S. R. "Mitochondrial DNA length variation in the mussel Mytilus." Thesis, Swansea University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636073.

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Three types of mitochondrial DNA length variation in <I>Mytilus</I> were examined. For the purposes of this study, the three variations were termed "macro-length-variation", "micro-length-variation" and "<I>trossulus</I>-length variation". Macro-length-variation was observed at a frequency of 25% at the hybrid <I>M.galloprovincialis/M. edulis</I> population at Mevagissey on the south Cornish coast, southwest England, Mitochondrial DNA (mtDNA) was extracted and digested with a diagnostic enzyme, <I>Eco</I>RI. Positive results with F-genome specific PCR primers and probes indicate that the macro

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14

Monckton, Darren G. "DNA sequence variation within and around human minisatellites." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34450.

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Hypervariable minisatellites have found increasing use in a wide range of applications including linkage analysis, relationship testing and forensic medicine. Conventional length analysis via restriction digestion, agarose gel electrophoresis and Southern blot hybridization produces at best, less than 100 resolvable alleles and involves inherently error prone length estimations. Forensic analyses based on such a system have recently been heavily criticised and the population assumptions used to calculate match frequencies questioned. However, allele length is not the only criterion by which mi

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15

Rehner, Stephen Austin. "Systematics, mating compatibility, and ribosomal DNA variation in Agrocybe section Pediadeae /." Thesis, Connect to this title online; UW restricted, 1989. http://hdl.handle.net/1773/5122.

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16

Watson, Michael Robert. "Heritable epigenetic variation of DNA methylation targets in plants." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5898/.

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DNA methylation marks regulate gene expression and genome structure. Stability and dynamics of DNA methylation patterns are influenced by four major factors including de novo methylation, maintenance methylation, passive loss of methylation and active demethylation. Maintenance methylation functions are still well conserved among plants and animals, which separated more than 1.5 billion years ago. In contrast, demethylation mechanisms differ considerably among plants and mammals. Interfering with DNA methylation and demethylation systems could be a source of heritable epigenetic variation if D

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17

Whittaker, S. L. "Genetics of P. infestans - variation in DNA content and ploidy." Thesis, Bangor University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280024.

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18

Jones, Catherine S. "Mitochondrial DNA variation in British house mice (Mus domesticus, Rutty)." Thesis, University College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426183.

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Morphometric, karyological and historical evidence indicates that Caithness and Orkney House mice (Mus.domesticus Rutty) are genetically distinct from other British mice, suggesting they are descended from introductions. Mitochondrial DNA is a small, rapidly evolving, maternally inherited molecule; hence each mtDNA molecule carries in its sequence the history of its lineage uncomplicated by recombination. Thus, mtDNA RFLPs can be used for analysing possible patterns of colonisation and gene flow in these populations. Highly purified mtDNA was isolated from each mouse and mapped, using the high

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19

Akhtar, Mahmood. "The role of DNA methylation in genetic variation of Listeria." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267155.

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20

O'Sullivan, Helen Mary. "DNA transactions involved in pilin variation in Neisseria meningitidis C311." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333670.

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21

Gomaa, R. "Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis." Thesis, Nottingham Trent University, 2010. http://irep.ntu.ac.uk/id/eprint/357/.

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The genetic sequence of human mitochondrial DNA (mtDNA) is of particular interest to forensic investigations involving human identification, as well as population genetics. The current mtDNA database is lacking sufficient representatives of African mitochondrial DNA sequences compared to European and Asian sequences. The present study was concerned with the analysis of mtDNA in the Egyptian population. FTA cards were used for blood sample collection, storage, and shipment and DNA extraction. An optimised laboratory protocol for rapid PCR amplification of the mitochondrial hypervariable regions

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22

MacDonald, Catherine. "Intraspecific and interspecific molecular variation in the Coelopidae." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367108.

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23

Coleman-Hulbert, Anna Luella. "Mitochondrial Inheritance and Natural Phenotypic Variation among Caenorhabditis briggsae Populations." PDXScholar, 2010. https://pdxscholar.library.pdx.edu/open_access_etds/340.

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Mutations affecting the mitochondrial electron transport chain cause numerous neurodegenerative disorders in humans and affect longevity in other organisms. A natural model system to study the relationship between mitochondrial function and aging within an evolutionary or population genetic context has been lacking. Natural populations of Caenorhabditis briggsae nematodes were recently found to harbor mitochondrial genetic variation with likely functional consequences for aging. Specifically, C. briggsae isolates containing high frequencies of a deletion mutation affecting the mitochondrial NA

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24

Adrian, Andrew B. "Fine scale recombination variation in Drosophila melanogaster." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2175.

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The study of natural variation is a principle component of biology. One process that affects levels of natural variation is meiotic recombination—the process by which homologous chromosomes break and interchange genetic information with one another during the formation of gametes. Surprisingly, this factor that shapes levels of natural variation across the genome itself presents with a great deal of variation. That variation manifests itself at many levels: within genomes, between individual organisms, across populations, and among species. The factors and mechanisms responsible for the non-ra

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25

Dunlop, Gordon. "Linking germination traits of oilseed rape (Brassica napus L.) to DNA markers." Thesis, Abertay University, 2000. https://rke.abertay.ac.uk/en/studentTheses/22973d1e-546d-4238-9ed8-32a4403f3a52.

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Oilseed rape has become an important weed in arable rotations and a feral plant of field margins, soil dumps and roadsides. Seed persistence in the soil following induced secondary dormancy is thought to perpetuate these weed and feral populations. Potential variation between cultivars has been suggested in previous work in the extent of secondary dormancy and other germination traits, and in underlying genetic heterogeneity. The aim of this work was to quantify in more detail inter- and intra- cultivar variation in germination traits for six oilseed rape cultivars, to confirm that variation w

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26

Smith, Melvin N. E. "Variation among native and alien populations of hoary mustard, Hirschfeldia incana (L.) Lagreze-Fossat, and the application of DNA melting analysis to investigate microsatellite (SSR) variation." Thesis, Swansea University, 2010. https://cronfa.swan.ac.uk/Record/cronfa42609.

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H. incana is a native species of the Mediterranean and Middle East. As a neophyte (alien) it has undergone a large range expansion in Northern Europe, the Americas, Asia and Australasia. Casual field observations suggested that within its native range, the dominant life strategy of H.incana was annual, whereas in the British flora it was predominantly perennial. Populations from native and alien ranges were studied in the field and in common garden experiments. Phenotypic differences in morphological and physiological characteristics were compared. Plants derived from neophyte British populati

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27

Modin, Helena. "Multiple sclerosis : linkage analysis and DNA variation in a complex trait /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-792-4/.

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28

Fredriksson, Mona. "Using Minisequencing Technology for Analysing Genetic Variation in DNA and RNA." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4789.

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<p>In this thesis, the four-color fluorescence tag-microarray minisequencing system pioneered by our group was further developed and applied for analysing genetic variation in human DNA and RNA. A SNP marker panel representing different chromosomal regions was established and used for identification of informative SNP markers for monitoring chimerism after stem cell transplantation (SCT). The success of SCT was monitored by measuring the allelic ratios of informative SNPs in follow-up samples from nine patients with leukaemia. The results agreed with data obtained using microsatellite markers.

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29

Angleby, Helen. "Analysis of domestic dog mitochondrial DNA sequence variation for forensic investigations." Licentiate thesis, Stockholm, Kungl. tekniska högskolan (KTH), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299.

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30

Bell, Joanna Sharlene. "Mismatch repair in DNA recombination and antigenic variation in Trypanosoma brucei." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394819.

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31

Mowforth, Miriam A. G. "Variation in nuclear DNA amounts in flowering plants : an ecological anlaysis." Thesis, University of Sheffield, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326707.

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32

Smyth, Audra Jayne. "Sequence variation in Leishmania kinetoplast DNA minicircles and diagnosis of leishmaniasis." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386238.

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33

Hernandez, D. M. G. "Genetic variation and DNA methylation in the context of neurological disease." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1485836/.

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Understanding genetic control of biological processes is an important goal in the post-genome era. GWA studies have been successful in identifying loci linked to disease and recently in revealing disease risk alleles. However, pinpointing key genes and their alterations within associated loci remains a central challenge. Described is the completion of a large, international metaanalysis and replication study of existing PD GWA data, confirming 6 previously identified loci and identifying and confirming an additional 5 novel loci; thus, expanding our understanding of the genetic basis of PD. Fo

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34

Givens, Chandler Brooke. "Genetic Variation Among Geographically Disparate Yellow Perch Broodstock Populations." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1385.

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35

Kuhn, Kristen Leigh. "Patterns of Microsatellite and Mitochondrial DNA Variation Among Anadromous and Freshwater Alewife (Alosa pseudoharengus) Populations." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/KuhnKL2004.pdf.

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36

Mutun, Serap Borst David Wellington. "Intraspecific mitochondrial DNA variation in the lubber grasshopper, Romalea guttata (Orthoptera : Acrididae)." Normal, Ill. Illinois State University, 1999. http://wwwlib.umi.com/cr/ilstu/fullcit?p9942647.

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Thesis (Ph. D.)--Illinois State University, 1999.<br>Title from title page screen, viewed July 24, 2006. Dissertation Committee: David W. Borst (chair), Angelo P. Capparella, Sabine S. Loew, Edward L. Mockford, Carleton J. Phillips, Douglas W. Whitman. Includes bibliographical references (leaves 77-89) and abstract. Also available in print.

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37

Niemi, A. K. (Anna-Kaisa). "Mitochondrial DNA variation in extremely selected traits: longevity and elite athletic performance." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:951427699X.

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Abstract Mitochondria contain a maternally inherited 16,568bp genome (mtDNA) that encodes for 13 out of more than 70 subunits of complexes of the respiratory chain that produce ATP by oxidative phosphorylation (OXPHOS). As a byproduct of OXPHOS, reactive oxygen species (ROS) are formed, which may play a role in ageing. MtDNA has accumulated numerous polymorphisms during evolution, leading to haplogroups characterized by ancient polymorphisms and defined by letters. MtDNA polymorphisms are thought to be neutral, but some may be slightly deleterious or even advantageous and may influence phenoty

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38

Mastana, Sarabjit Singh. "Genetic variation and structure in selected human populations : serogenetic and DNA studies." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261150.

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39

Plaster, C. A. "Variation in Y chromosome, mitochondrial DNA and labels of identity on Ethiopia." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331901/.

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There is a paucity of genetic studies of Ethiopia. This thesis aims to establish the extent and distribution of variation in NRY and mtDNA genetic markers as well as ethnic and linguistic labels of identity 45 ethnic groups. A wide range of NRY and mtDNA haplogroups were observed, including both those typically observed in Africa and those more frequently observed outside Africa. Significant correlations were revealed between NRY and mtDNA diversity. Nearly all ethnic groups were significantly differentiated from each other, although the pattern of similarities indicates some recent gene flow

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40

Cosner, Mary Elizabeth. "Phylogenetic and molecular evolutionary studies of chloroplast DNA variation in the campanulaceae /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487847761306203.

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41

Elguzouli, Amna Eltayeb. "MITOCHONDRIAL DNA SEQUENCE VARIATION IN THE AFRICAN ARMYWORM SPODOPTERA EXEMPTA (LEPIDOPTERA: NOCTUIDAE)." OpenSIUC, 2013. https://opensiuc.lib.siu.edu/theses/1346.

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AN ABSTRACT OF THE THESIS OF AMNA E. ELGUZOULI, for the Master of Science degree in ZOOLOGY, presented on May 8, 2012, at Southern Illinois University TITLE: Mitochondrial DNA sequence variation in the African Armyworm Spodoptera exempta (Lepidoptera: Noctuidae) MAJOR PROFESSOR: Kamal M. Ibrahim The African Armyworm remains problematic as a serious pest of cereals in sub-Sahara Africa. The population genetic structure of African armyworms was investigated to better understand the species' population dynamics and the extent to which the two major outbreak areas in East Africa and Southern Afric

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42

Elrod, Diana Adams. "Mitochondrial DNA Sequence Variation in Populations of the Nine-Banded Armadillo (Dasypus novemcinctus)." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2577/.

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Four populations of nine-banded armadillos, Dasypus novemcinctus, were investigated in the south-central United States in order to assess genetic variation in an isolated population (Electric Island, Lake Hamilton, Garland County, Arkansas); a semi-isolated population (Arkansas Post, Arkansas County, Arkansas), and two free ranging populations (southern Arkansas and central Texas). A 233 basepair sequence of the D-loop region of mitochondrial DNA was sequenced in individuals from each population. Individuals and populations were compared to assess relatedness among populations and individuals.

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43

Lindstedt, Elenor. "Genetic variation between and within populations of Leucorrhinia dubia in Sweden, Finland and Norway." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-30990.

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Genom att extrahera, amplifiera och sekvensera DNA från ben av trollsländeartenLeucorrhinia dubia ämnar jag få en inblick i hur arter invandrat till Skandinavien sedan densenaste istiden och en mindre inblick i den genetiska variationen av arten i Skandinavien. Fördetta valdes en mitokondrisk gen (cytochrome c oxidase subunit I, COI) och en nukleär (28sribosomal RNA subunit D7). Totalt blev det 112 sekvenser (55 av COI genen och 57 för D7genen) från 10 olika populationer i Sverige, Norge och Finland som delade upp sig i tvåseparata klader med lite variation mellan individerna i de fylogenetisk

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44

Labuschagne, Jeanine. "Molecular methods for genotyping selected detoxification and DNA repair enzymes / J. Labuschagne." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4599.

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The emerging field of personalized medicine and the prediction of side effects experienced due to pharmaceutical drugs is being studied intensively in the post genomic era. The molecular basis of inheritance and disease susceptibility is being unravelled, especially through the use of rapidly evolving new technologies. This in turn facilitates analyses of individual variations in the whole genome of both single subjects and large groups of subjects. Genetic variation is a common occurrence and although most genetic variations do not have any apparent effect on the gene product some do exhibit

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45

McGlashan, Dugald James. "Consequences of Dispersal, Stream Structure and Earth History on Patterns of Allozyme and Mitochondrial DNA Variation of Three Species of Australian Freshwater Fish." Thesis, Griffith University, 2000. http://hdl.handle.net/10072/366647.

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Freshwater systems offer important opportunities to investigate the consequences of intrinsic biological and extrinsic environmental factors on the distribution of genetic variation, and hence population genetic structure. Drainages serve to isolate populations and so preserve historical imprints of population processes. Nevertheless, dispersal between and within drainages is important if the biology of the species confers a good dispersal capability. Knowledge of the population genetic structure or phylogeographic patterns of Australia's freshwater fish fauna is generally depauperate, and the

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46

Peterson, Russ. "An examination of Crassostrea virginica nuclear DNA variation along the North Carolina coast /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/petersonr/russpeterson.pdf.

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47

Siemann, Liese Anne 1966. "Mitochondrial DNA sequence variation in North Atlantic long-finned pilot whales, Globicephala melas." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/11943.

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48

Bofkin, Lee Nathan Marc. "The causes and consequences of variation in evolutionary processes acting on DNA sequences." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613925.

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49

Beech, Robin Nicholas. "Insertion-deletion variation in the DNA of three natural populations of Drosophila melanogaster." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/10772.

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50

Henson, Brian Junior. "Evolution, Variation, and Excision of Developmentally Regulated DNA Elements in the Heterocystous Cyanobacteria." Miami University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=miami1132247140.

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