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Dissertations / Theses on the topic 'DnaB helicase'

Author: Grafiati

Published: 4 March 2024

Last updated: 31 July 2025

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1

Atkinson, John David. "Regulation of the E. coli Replicative Helicase DnaB by the Helicase Loader DnaC." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485809.

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The helicase proteins directly ~esponsible for unwinding chromosomal DNA during DNA replication in bacteria, archaea and eukaryotes adopt a ring-shaped conformation for rapid displacement ofthe parental DNA duplex. As the DNA substrate is engulfed by the helicase during t~slocation, accessory proteins are required for placement ofthe helicase onto the DNA substrate either by breaking the ringed complex, thus allowing DNA to pass into the central channel, or by assembling the helicase around the DNA. In E. coli, the replicative helicase is a hexameric complex of six DnaB monomers, whilst the ac

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2

Arribas, Bosacoma Raquel. "Resolució de l'estructura tridimensional de l'helicasa hexamètrica DnaB." Doctoral thesis, Universitat de Girona, 2009. http://hdl.handle.net/10803/7639.

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Es presenta el model atòmic a 4.5 Å de DnaB, la principal helicasa replicativa bacteriana, d'Aquifex aeolicus. És un anell hexamèric de 100 Å d'amplada i 80 Å d'alçada amb dues capes de simetria diferenciada, la dels dominis N-terminals en C3 i la dels C-terminals propera a C6. El diàmetre central és de 25 Å al llarg d'ambdues capes, principal diferència amb les estructures prèvies, on era 25 Å més estret a la capa N-terminal. L'estretament s'origina pel trencament d'una de les dues superfícies d'interacció entre monòmers N-terminals, cosa que augmenta la flexibilitat del subdomini implicat. N

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3

Lo, Allen Tak Yiu. "Protein dynamics on the lagging strand during DNA synthesis." Thesis, School of Chemistry, 2012. https://ro.uow.edu.au/theses/3684.

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DNA replication is one of the vital processes in the cell; it duplicates chromosomal DNA before a cell divides. In all organisms, DNA synthesis on the leading-strand template occurs continuously, whereas on the lagging strand a different mechanism is required. Due to the anti-parallel structure of double-stranded DNA, lagging-strand synthesis requires repeated RNA priming by a specialist primase and synthesis of short Okazaki fragments. How proteins carry out this dynamic process is still unknown. For Escherichia coli DNA replication, a lagging-strand three-point switch was proposed in 1999 to

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4

Weigelt, Johan. "Development of new NMR techniques and the structure of the N-terminal domain of Escherichia coli DnaB helicase /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3414-2.

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5

McRobbie, Anne-Marie M. "Splitting, joining and cutting : mechanistic studies of enzymes that manipulate DNA." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/951.

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DNA is a reactive and dynamic molecule that is continually damaged by both exogenous and endogenous agents. Various DNA repair pathways have evolved to ensure the faithful replication of the genome. One such pathway, nucleotide excision repair (NER), involves the concerted action of several proteins to repair helix-distorting lesions that arise following exposure to UV light. Mutation of NER proteins is associated with several genetic diseases, including xeroderma pigmentosum that can arise upon mutation of the DNA helicase, XPD. The consequences of introducing human mutations into the gene en

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6

Song, Daqing. "Homologous Strand Exchange and DNA Helicase Activities in Plant Mitochondria." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd931.pdf.

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7

Rudolf, Jana. "Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase." Thesis, St Andrews, 2007. http://hdl.handle.net/10023/159.

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8

Leah, Labib. "Helicase Purification for DNA Sequencing." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31341.

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BACKGROUND: A method to increase accuracy and ease-of-use, while decreasing time and cost in deoxyribonucleic acid (DNA) sequence identification, is sought after. Helicase, which unwinds DNA, and avidin, which strongly attracts biotin for potential attraction of biotinylated DNA segments, were investigated for use in a novel DNA sequencing method. AIM: This study aimed to (1) purify bacteriophage T7 gene product 4 helicase and helicase-avidin fusion protein in a bacterial host and (2) characterize their functionality. METHODS: Helicase and helicase-avidin were cloned for purification from bact

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9

Korhonen, Jenny. "Functional and structural characterization of the human mitochondrial helicase /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-102-2/.

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10

Johnson, Vinu. "Structural and Biophysical Studies of Single-Stranded DNA Binding Proteins and dnaB Helicases, Proteins Involved in DNA Replication and Repair." University of Toledo / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1198939056.

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11

Tasleem, Arsala. "Helicase Attachment to Carbon Nanotubes for DNA Sensor." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37392.

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Purpose: Current DNA detection techniques require complicated procedures, specialized training, expensive equipment, invasive samples and significant amount of sample collection and processing time. The purpose of this research was to develop a rapid, accurate, non-invasive and electronic method of DNA sensing that harnesses natural unwinding properties of DNA helicase by attaching it to Carbon Nanotubes. Methods: a. A literature review on methods of attaching proteins to carbon nanotubes was conducted b. A design of the biosensor was developed based on previously reported attachment metho

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12

Dillingham, Mark Simon. "Biochemical studies on DNA helicases." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312245.

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13

Mankouri, Hocine William. "DNA helicases and yeast ageing." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367550.

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14

Tognetti, Silvia. "Helicase activation mechanisms during initiation of DNA replication." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/40925.

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This thesis provides new insights into the recruitment mechanisms of factors to replicative origins that are important for helicase activation during initiation of DNA replication in budding yeast. DNA replication origins are recognised by the Origin Recognition Complex (ORC), which recruits, during late M-phase, Cdc6, Cdt1 and MCM2-7 to form a pre-replication complex (pre-RC). MCM2-7 represents the core of the eukaryotic replicative helicase, but it is inactive within the pre-RC. In early S-phase, the pre-RC is converted into the pre-initiation complex (pre-IC), leading to stable Cdc45/GINS/M

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15

Harrison, Ryan M. "Molecular biophysics of strong DNA bending and the RecQ DNA helicase." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f02fc167-b705-4275-a413-21d13b5d94c3.

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Molecular biophysics is a rapidly evolving field aimed at the physics-based investigation of the biomolecular processes that enable life. In this thesis, we explore two such processes: the thermodynamics of DNA bending, and the mechanism of the RecQ DNA helicase. A computational approach using a coarse-grained model of DNA is employed for the former; an experimental approach relying heavily on single-molecule fluorescence for the latter. There is much interest in understanding the physics of DNA bending, due to both its biological role in genome regulation and its relevance to nanotechnology.

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16

Ozdemir, Ahmet Yunus. "BIOCHEMICAL STUDIES OF DNA POLYMERASE THETA." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/560412.

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Biomedical Sciences<br>Ph.D.<br>POLQ is a unique multifunctional replication and repair gene that encodes a multidomain protein with a N-terminal superfamily 2 helicase and a C-terminal A-family polymerase. Although the function of the polymerase domain has been investigated, little is understood regarding the helicase domain. Multiple studies have reported that polymerase θ-helicase (Polθ-helicase) is unable to unwind DNA. However, it exhibits ATPase activity that is stimulated by single-stranded DNA, which presents a biochemical conundrum. In contrast to previous reports, we demonstrate that

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17

Cavanagh, David R. "DNA helicase II and exonuclease V of Escherichia coli." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293560.

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18

Huber, Michael D. "Structure-function analysis and substrate specific inhibition of RecQ helicases /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9253.

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19

McFarlane-Majeed, Laura. "A functional characterisation of the DNA helicase Ch1R1 in DNA replication and repair." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5919/.

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ChlR1 is a DNA helicase implicated in diverse cellular processes including sister chromatid cohesion and DNA replication and repair. However, the mechanism by which ChlR1 participates in these processes is unknown. Data presented in this thesis show that siRNA-mediated depletion of ChlR1 causes increased sensitivity to chemically-induced replication stress. Treatment of ChlR1-depleted cells with hydroxyurea results in increased mono-ubiquitination of PCNA and increased chromatin-associated RPA, indicating stalled DNA replication. Furthermore, ChlR1 is recruited to chromatin following hydroxyur

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20

Levin, Mikhail Konstantinovich. "DNA UNWINDING MECHANISM OF THE HELICASE FROM HEPATITIS C VIRUS." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1017851412.

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21

Jordan, Christian. "Helicase-SSB Interactions In Recombination-Dependent DNA Repair and Replication." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/270.

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Dda, one of three helicases encoded by bacteriophage T4, has been well- characterized biochemically but its biological role remains unclear. It is thought to be involved in origin-dependent replication, recombination-dependent replication, anti- recombination, recombination repair, as well as in replication fork progression past template-bound nucleosomes and RNA polymerase. One of the proteins that most strongly interacts with Dda, Gp32, is the only single-stranded DNA binding protein (SSB) encoded by T4, is essential for DNA replication, recombination, and repair. Previous studies have shown

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22

Sedman, Tiina. "Characterization of the yeast Saccharomyces Cerevisiae mitochondrial DNA helicase hmi1 /." Online version, 2005. http://dspace.utlib.ee/dspace/bitstream/10062/1332/5/sedman.pdf.

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23

Manhi, Hoida Ismail Abdel-Aziz. "Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences." Kyoto University, 2011. http://hdl.handle.net/2433/142044.

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24

Zhong, Yichen. "Mechanistic Studies of Human Chromodomain-Helicase-DNA-Binding Protein 4." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23473.

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In eukaryotic cells, genomic DNA is organized into small units called nucleosomes, each of which generally consists of a histone octamer and DNA wrapping around this histone core, so that the whole genome can be efficiently packed into a small nucleus. On the other hand, the presence of nucleosome remodelers ensures the genetic information still remains accessible to regulatory factors. Although it was known for a long time that these remodellers can weaken the interaction between the DNA and histones in an ATP-dependent manner to expose part of the DNA sequence, the underlying mechanisms have

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25

Tokonzaba, Etienne. "Molecular mechanism of SV40 large tumor antigen helicase /." Connect to abstract via ProQuest. Full text is not available online, 2007.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 82-92; 128-134). Online version available via ProQuest Digital Dissertations.

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26

Ali, Yusuf I. "Design, synthesis and characterisation of tool inhibitors targeting BLM helicase." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/80487/.

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27

Richards, Jodi Dominique. "Helicases and DNA dependent ATPases of Sulfolobus solfataricus /." St Andrews, 2008. http://hdl.handle.net/10023/474.

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28

Richards, Jodi D. "Helicases and DNA dependent ATPases of Sulfolobus solfataricus." Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/474.

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DNA is susceptible to various types of damage as a result of normal cellular metabolism or from environmental sources. In order to maintain genome stability a number of different, partially overlapping DNA repair pathways have evolved to tackle specific lesions or distortions in the DNA. Nucleotide excision repair (NER) is highly conserved throughout eukarya, bacteria and archaea and predominantly targets lesions that result from exposure to UV light, for example cyclobutane pyrimidine dimers and 6-4 photoproducts. The majority of archaea possess homologous of the eukaryotic repair genes and t

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29

Ochem, Alexander. "Properties of two DNA helicases of human cells." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299015.

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30

Syed, Salahuddin. "Nonreplicative DNA Helicases Involved in Maintaining Genome Stability." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6408.

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Double-strand breaks and stalled forks arise when the replication machinery encounters damage from exogenous sources like DNA damaging agents or ionizing radiation, and require specific DNA helicases to resolve these structures. Sgs1 of Saccharomyces cerevisiae is a member of the RecQ family of DNA helicases and has a role in DNA repair and recombination. The RecQ family includes human genes BLM, WRN, RECQL4, RECQL1, and RECQL5. Mutations in BLM, WRN, and RECQL4 result in genetic disorders characterized by developmental abnormalities and a predisposition to cancer. All RecQ helicases have comm

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31

Markham, Jonathan Edward. "Biotin-containing enzymes from Brassica napus and Arabidopsis thaliana." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/1648/.

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32

Chilton, Scott S. "A mutational analysis of the Bacillus subtilis competence helicase ComFA." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11560.

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Genetic competence is a developmental process in bacteria that allows natural transformation. Competent Gram positive bacteria such as Bacillus subtilis carry a cytosolic helicase which is required for efficient transformation. In this work ComFA is confirmed as a DEAD-box helicase. I also describe a new accessory motif in ComFA that contributes to transformation independently of the helicase activity in ComFA. The newly discovered metal-binding motif consists of four cysteines which are required for transformation and zinc binding. While the zinc finger is required for full function, it i

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33

Cassidy, Sarah Anne. "Stabilisation of DNA triple helices." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242535.

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34

Novoa, Carolina. "RecQ-like helicase SGS1 counteracts DNA : RNA hybrid induced genome instability." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60964.

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Dividing cells are constantly under threat from both endogenous and exogenous DNA damaging stresses that can lead to mutations and structural variations in DNA. One contributor to genome instability is three-stranded DNA:RNA hybrid structures called R-loops. Though R-loops are known to induce DNA damage and DNA replication stress, it is unclear whether they are recognized and processed by an established DNA repair pathway prior to inducing DNA breaks. Canonically, DNA repair proteins work downstream of R-loop-induced DNA damage to stimulate repair and suppress genome instability. Recently, the

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35

ROSSI, SILVIA EMMA. "INTERPLAY BETWEEN THE DNA HELICASES PIF1 AND RRM3, THE NUCLEASE DNA2 AND THE CHECKPOINT PATHWAYS IN THE MAINTENANCE OF THE DNA REPLICATION FORK INTEGRITY." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/471797.

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Eukaryotic cells have evolved the ATR/hCHK1, MEC1/RAD53 kinase-mediated signal transduction pathway, known as replication checkpoint, to protect and stabilize stalled replication forks in human cells and budding yeasts, respectively. rad53 mutants, exposed to high doses of the DNA replication inhibitor hydroxyurea (HU), accumulate hemireplicated, gapped and reversed forks, while treatments with low HU doses induce massive chromosome fragmentation. The aim of my work was to better understand the molecular mechanisms through which Rad53 prevents unusual alterations of the architecture of the

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36

Klaue, Daniel. "DNA Unwinding by Helicases Investigated on the Single Molecule Level." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-97596.

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Each organism has to maintain the integrity of its genetic code, which is stored in its DNA. This is achieved by strongly controlled and regulated cellular processes such as DNA replication, -repair and -recombination. An essential element of these processes is the unwinding of the duplex strands of the DNA helix. This biochemical reaction is catalyzed by helicases that use the energy of nucleoside triphophate (NTP) hydrolysis. Although all helicases comprise highly conserved domains in their amino acid sequence, they exhibit large variations regarding for example their structure, their functi

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37

Bailey, Scott. "Structural investigations of the Bacillus subtilis SPP1 phage G39P helicase inhibitor loading protein." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246919.

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38

Langland, Gregory Todd. "Interaction Between the BLM Helicase and the DNA Mismatch Repair Protein, MLH1." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1052316756.

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39

Brüning, Jan-Gert. "Underpinning replication of protein-bound DNA by the accessory replicative helicase Rep." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/8220/.

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Accurate DNA replication must occur prior to every cell division. However, replication forks often stall at sites of DNA damage and protein-DNA complexes. If not removed, these blocks can threaten the viability of both daughter cells by preventing the completion of genome duplication or by targeting of blocked forks by recombination enzymes that can result in gross chromosomal rearrangements and genome instability. The importance of minimising fork blockage has resulted in cells evolving repair systems to remove lesions from DNA whilst accessory replicative helicases can underpin replication f

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40

Chou, Ta-Chung. "The molecular role of the Saccharomyces cerevisiae DNA helicase Srs2 during meiosis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/8446/.

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41

Lee, Myung Soo. "Studies on the DNA helicase activities of the Escherichia coli primosome : involved in DNA replication fork movement /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744115351&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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42

Bernard, Emmanuelle Alexa. "Cloning and characterisation of the Xenopus laevis bloom's protein." Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367351.

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43

Paes, Hazel Margaret. "The kinetics of DNA triple helices." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242691.

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44

Fletcher, Ryan James. "Structural and biochemical studies of mini-chromosomal maintenance proteins /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Biochemistry and Molecular Genetics) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 84-97). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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45

Meistermann, Isabelle. "DNA major groove recognition by supramolecular helicates." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246782.

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46

Yu, Jei-Hwa. "MAPKs regulate nuclear import of human papillomavirus type 11 replicative helicase E1." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/yu.pdf.

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47

Burrage, Joseph. "Analysis of the function of LSH in DNA damage repair." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/9416.

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DNA damage from both normal metabolic activities and environmental factors such as UV and radiation can cause as many as 1 million individual lesions to the DNA per cell per day (Lodish et al 2004). Cells respond to this continuous damage by employing many, highly efficient DNA repair mechanisms and undergo apoptosis when normal DNA repair fails. Of the many types of DNA damage that can occur, double strand breaks (DSBs) are the most toxic (Featherstone & Jackson 1999). A single unrepaired DSB is enough to induce cellular apoptosis and several mechanisms have developed to repair DSBs. The reco

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48

Zecevic, Alma. "Role of WRN helicase in repair of chromate induced DNA damage : final version." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318377.

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49

Hunt, Laura. "Investigating the role of the Srs2 DNA helicase during meiosis in S. cerevisiae." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19942/.

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During cell division, duplicated chromosomes must be segregated faithfully to prevent aneuploidy in daughter cells. In meiosis, there are two rounds of division following a single round of DNA replication. In the first meiotic division, crossovers formed between homologous chromosomes, via homologous recombination, ensure correct DNA segregation. Homologous recombination is intitated by DNA double-strand breaks (DSBs), which are processed to form single-stranded DNA that can invade donor duplexes to effect repair. In yeast, formation of nucleoprotein-filaments (NPFs) by RecA homologues Rad51 a

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50

Litman, Rachel. "Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/329.

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DNA damage response pathways are a complicated network of proteins that function to remove and/or reverse DNA damage. Following genetic insult, a signal cascade is generated, which alerts the cell to the presence of damaged DNA. Once recognized, the damage is either removed or the damaged region is excised, and the original genetic sequence is restored. However, when these pathways are defective the cell is unable to effectively mediate the DNA damage response and the damage persists unrepaired. Thus, the proteins that maintain the DNA damage response pathway are critical in preserving genomic

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