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Dissertations / Theses on the topic 'DNMT2'

Author: Grafiati
Published: 10 December 2022
Last updated: 31 July 2025

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1

Müller, Sara [Verfasser]. "Biologische Funktionsanalyse und Identifizierung neuer Substrate der Methyltransferase Dnmt2 / Sara Müller." Kassel : Universitätsbibliothek Kassel, 2012. http://d-nb.info/101926845X/34.

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2

Kiani, Jafar. "Hérédité épigénétique et méthylation des ARNs : rôle de la méthyltransférase Dnmt2." Nice, 2011. http://www.theses.fr/2011NICE4093.

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Epigenetics deals with heritable alterations in gene expression that is not based on changes n DNA sequence. It was thought that DNA methylation and chromatin-encoded epigenetic information were the only epigenetic marks transmitted to the following generations. Recently, our group described the role of RNA in hereditary epigenetic variation, paramutation in mice. The role of RNA was demonstrated by the establishment of a heritable phenotype following microinjection into one-cell embryos of Kit heterozygous sperm RNA. It was further confirmed by induction of hereditary phenotypes after microin
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3

Schuster, Isabelle [Verfasser]. "Strukturelle und funktionelle Charakterisierung des Dnmt2-Homologs DnmA von Dictyostelium discoideum / Isabelle Schuster." Kassel : Universitätsbibliothek Kassel, 2016. http://d-nb.info/1101616091/34.

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4

Hartmann, Mark [Verfasser], and Frank [Akademischer Betreuer] Lyko. "Centromeric tRNA and Dnmt2-mediated Methylation in Mitotic Chromosome Segregation / Mark Hartmann ; Betreuer: Frank Lyko." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177148862/34.

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5

Durdevic, Zeljko [Verfasser], and Frank [Akademischer Betreuer] Lyko. "Characterization of the Biological Function of Dnmt2 in Drosophila melanogaster / Zeljko Durdevic ; Betreuer: Frank Lyko." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177249774/34.

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6

Kaiser, Steffen [Verfasser]. "Investigations on DNA methylation by Dnmt2 and impact of tRNA modifications on TLR7 stimulation / Steffen Kaiser." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1080401431/34.

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7

Shanmugam, Raghuvaran [Verfasser], and Albert [Akademischer Betreuer] Jeltsch. "Biochemical characterisation of tRNA-Asp methyltransferase Dnmt2 and its physiological significance / Raghuvaran Shanmugam. Betreuer: Albert Jeltsch." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2014. http://d-nb.info/1049931661/34.

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8

Vieira, Gilberto Cavalheiro. "Modelagem molecular e imunodetecção de DNA Metiltransferases 2 de Drosofilídeos : uma abordagem evolutiva da enigmática DNMT2." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/117889.

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A metilação do DNA genômico é um dos principais mecanismos de regulação epigenética nos organismos. Dentre as diferentes classes de DNA MTase, as m5C-MTase são as que se distribuem amplamente de procariotos a eucariotos. Em vertebrados existem três diferentes famílias: DNMT1, DNMT2 e DNMT3a e 3b. A DNMT1 possui atividade junto ao DNA hemimetilado. As DNMT3a e 3b são responsáveis pela metilação de novo. Já a subfamília DNMT2 possui seus sítios catalíticos altamente conservados, desde procariotos até eucariotos, possuindo propriedades que permitem executar funções tanto de metilação de novo, ass
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Liebers, Reinhard Kai [Verfasser], and Frank [Akademischer Betreuer] Lyko. "Dnmt2 in RNA methylation, RNA inheritance, and environmental responses in the mouse / Reinhard Kai Liebers ; Betreuer: Frank Lyko." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180614186/34.

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10

Liebers, Reinhard [Verfasser], and Frank [Akademischer Betreuer] Lyko. "Dnmt2 in RNA methylation, RNA inheritance, and environmental responses in the mouse / Reinhard Kai Liebers ; Betreuer: Frank Lyko." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180614186/34.

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11

FILIP, Kamila Maria. "Effects of 5-Azacitidine on Dnmt2/Trdmt1 expression levels and endoplasmic reticulum stress in cellular models of insulinoma." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/514949.

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Diabetes mellitus affects people all over the world of all ages or social groups making it a worldwide healthcare challenge. Moreover, untreated or badly treated diabetes carries a risk of serious complications including premature death (IDF Diabetes Atlas 9th edition, 2019). The main symptom of diabetes is insulin secretion and/or action disorder leading to hyperglycemia what results in impaired carbohydrate, fat, and protein metabolism (“Diagnosis and Classification of Diabetes Mellitus,” 2013). Dnmt2/ Trdmt1 in its structure and sequence is similar to DNA methyltransferases, how
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12

Becker, Maria [Verfasser], Ann [Akademischer Betreuer] Ehrenhofer-Murray, and Bernhard [Akademischer Betreuer] Horsthemke. "Characterization of the Dnmt2 homolog Pmt1 in Schizosaccharomyces pombe / Maria Becker. Gutachter: Ann Ehrenhofer-Murray ; Bernhard Horsthemke. Betreuer: Ann Ehrenhofer-Murray." Duisburg, 2013. http://d-nb.info/1041831803/34.

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13

Windhof-Jaidhauser, Indra Maria [Verfasser]. "Zelluläre und biochemische Charakterisierung der bifunktionalen Methyltransferase Dnmt2 / Indra Maria Windhof-Jaidhauser. Kassel, Universität, FB 10, Mathematik und Naturwissenschaften, Institut für Biologie." Kassel : Universitätsbibliothek Kassel, 2014. http://d-nb.info/1058420232/34.

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14

Baudouy, Delphine. "Rôles des gènes PPARβ/δ, Wt1, Cyp51 et Dnmt2 dans l'angiogenèse et la fonction cardiaque chez la souris adulte saine et dans un modèle d'infarctus du myocarde". Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4148.

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La coronaropathie est une cause majeure de mortalité, motivant la recherche de stratégies limitant le remodelage cardiaque ou stimulant la néovascularisation après un infarctus du myocarde (IDM). Ce travail vise à étudier chez la souris adulte le rôle, sur la fonction cardiaque, de gènes régulant l'angiogenèse et le métabolisme cellulaire en modulant leur expression endothéliale en conditions basales ou en post-IDM (après ligature coronaire) : PPARβ/δ, Wt1, Cyp51 et Dnmt2. Les paramètres échocardiographiques ont été mesurés pré et post-IDM, des analyses histochimiques réalisées, et l’expressio
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Baudouy, Delphine. "Rôles des gènes PPARβ/δ, Wt1, Cyp51 et Dnmt2 dans l'angiogenèse et la fonction cardiaque chez la souris adulte saine et dans un modèle d'infarctus du myocarde". Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4148/document.

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La coronaropathie est une cause majeure de mortalité, motivant la recherche de stratégies limitant le remodelage cardiaque ou stimulant la néovascularisation après un infarctus du myocarde (IDM). Ce travail vise à étudier chez la souris adulte le rôle, sur la fonction cardiaque, de gènes régulant l'angiogenèse et le métabolisme cellulaire en modulant leur expression endothéliale en conditions basales ou en post-IDM (après ligature coronaire) : PPARβ/δ, Wt1, Cyp51 et Dnmt2. Les paramètres échocardiographiques ont été mesurés pré et post-IDM, des analyses histochimiques réalisées, et l’expressio
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16

Rosa, Cristiane de Santis Alves [UNESP]. "Análise funcional do papel da enzima DNA metiltransferase 2 (DNMT2) no desenvolvimento e resposta à estresses e identificação e caracterização de fragmentos derivados de tRNA (tRFs) em Arabidopsis thaliana." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/144083.

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Made available in DSpace on 2016-09-27T13:40:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-08-07. Added 1 bitstream(s) on 2016-09-27T13:45:16Z : No. of bitstreams: 1 000868866.pdf: 3890512 bytes, checksum: 0cfe144754a164b6e99ae94352b6d9c8 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A metilação do DNA está relacionada à regulação gênica, memória celular, silenciamento de elementos transponíveis, imprinting genô
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Rosa, Cristiane de Santis Alves. "Análise funcional do papel da enzima DNA metiltransferase 2 (DNMT2) no desenvolvimento e resposta à estresses e identificação e caracterização de fragmentos derivados de tRNA (tRFs) em Arabidopsis thaliana." Botucatu, 2015. http://hdl.handle.net/11449/144083.

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Orientador: Fabio Tebaldi Silveira Nogueira<br>Banca:??<br>Resumo: A metilação do DNA está relacionada à regulação gênica, memória celular, silenciamento de elementos transponíveis, imprinting genômico e repressão de pseudoelementos provenientes de sequências duplicadas. Os padrões de metilação são estabelecidos, mantidos e traduzidos em estados funcionais apropriados da maquinaria de metilação do DNA, a qual inclui uma família classificada em três grupos de enzimas do tipo metiltransferases: DNMT1, DNMT3 e DNMT2. A DNA metiltransferase 2 (DNMT2) foi identificada na busca de novos candidatos à
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18

BAIAMONTE, Concetta. "Reactivation of SNURF-SNRPN gene by DNA Methyltransferase inhibitors in a Prader-Willi lymphoblastoid cell line." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91240.

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19

Unterberger, Alexander. "The role of DNMT1 regulation in cellular function." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92154.

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Disruption of the epigenome and its components is a hallmark of all forms of cancer. Typically observed in cancer is an alteration of the DNA methylation pattern, with silencing of tumour suppressor genes, as well as an increase in DNA methyltransferase 1 (activity or expression). However it has yet to be determined exactly how DNMT1 increases in cancer and how this increase might serve as therapeutic target. This thesis focuses on the regulation of DNMT1 in the cell cycle and the consequences of depleting DNMT1 in cancer cells.<br>During the cell cycle DNMT1 levels increase as the cell enters
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20

Balinang, Joyce. "The Regulation of Mitochondrial DNMT1 During Oxidative Stress." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2826.

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Epigenetics is the study of heritable gene expression due to alterations in the DNA structure other than the underlying DNA sequence. DNA methylation is one of the three types of epigenetic modifications found in the eukaryotic system. It involves the incorporation of a methyl group at the 5-position of cytosine residues in the DNA. DNA methylation is associated with several notorious disorders and diseases including Fragile X Syndrome, neurodegenerative disease (Parkinson’s, Alzhiemer, etc), diabetes and cancer. Cytosine methylation of mitochondrial DNA (mtDNA) was first demonstrated several
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21

Dunne, Philip D. "DNA damage response in MLH1-and DNMT1-depleted cells." Thesis, University of Ulster, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551590.

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Every day each cell in the body is under threat from DNA damaging agents that have the potential to disrupt the passing of intact genetic information from one generation to the next. The presence of a wide variety of threats has led to the evolution of numerous DNA damage response pathways in order to deal with the damage that they may cause. The mismatch repair system is primarily responsible for the removal of incorrect base insertions and deletions occurring during replication and its importance is highlighted by its conservation from bacteria to humans. MLHl is one of the main components o
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22

Horowitz, Evan Richard Kopp. "Dnmt1 Expression is Required for Lens Epithelial Cell Survival." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1438379221.

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23

Stabellini, Raquel. "Análise funcional dos genes Xist e DNMT1 na manutenção do processo de inativação do cromossomo X humano através do silenciamento gênico por RNAi." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-26082008-162745/.

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A inativação do cromossomo X (ICX) é o fenômeno através do qual um dos cromossomos X das fêmeas de mamíferos é silenciado para atingir compensação de dose em relação aos machos. Ela envolve a expressão do gene XIST exclusivamente no X inativo, e a associação em cis de seu RNA nesse cromossomo. Isso inicia a imposição de várias marcas epigenéticas no cromossomo X inativo, que garantem a manutenção deste estado de silenciamento transcricional de maneira estável durante todas as mitoses num organismo. Uma dessas modificações epigenéticas é a metilação do DNA, desempenhada principalmente pela enz
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24

Halby, Ludovic. "Conception et synthèse de nouveaux inhibiteurs de DNMT." Paris 6, 2013. http://www.theses.fr/2013PA066823.

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25

Pechalrieu, Dany. "Des inhibiteurs de méthyltransférases de l'ADN au développement de sondes chimiques pour l'identification de modulateurs épigénétiques dérégulés dans les cancers." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30185.

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Les méthyltransférases de l'ADN (DNMT) catalysent la méthylation de l'ADN, l'une des marques épigénétiques les plus étudiées. Dans les cancers, on observe une hyperméthylation spécifique de promoteurs de gènes suppresseurs de tumeurs (GST) conduisant à leur extinction génique, ce qui participe au maintien et à la progression de tumeurs. A ce jour, les mécanismes responsables de cette hyperméthylation spécifique des promoteurs de GST dans les cancers sont indéterminés. Ces travaux de thèse sont consacrés à l'inhibition des DNMT dans les cancers afin de restaurer l'expression des GST mais égalem
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Ferro, Leonardo Borges. "Imuno-expressão da DNMT1, DNMT3a e DNMT3b nos tumores odontogênicos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-20022014-162146/.

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Os tumores odontogênicos são um grupo heterogéneo de lesões formadas a partir de tecidos que dão origem ao dente. A metilação do ADN, uma adição covalente de um grupo metilo na posição 5 de carbono de um nucleótideo de citosina, é considerado um importante regulador da expressão génica. A adição do radical metil é catalisada por ADN metiltransferases (DNMTs). Embora alguns estudos epigenéticos tenham sido realizados em tumores odontogênicos, um estudo com os três tipos de DNMTs em vários membros desse grupo está em falta. Este estudo analisa a expressão de DNMTs em tumores odontogênicos. Amost
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Kuch, David. "Synthese und Charakterisierung neuartiger Inhibitoren für die humane DNA Methyltransferase DNMT1 /." München : Dr. Hut Verlag, 2009. http://edoc.ub.uni-muenchen.de/9490/.

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Kuch, David. "Synthese und Charakterisierung neuartiger Inhibitoren für die humane DNA Methyltransferase DNMT1." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-94905.

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29

Zampieri, Michele. "Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation." Doctoral thesis, La Sapienza, 2007. http://hdl.handle.net/11573/916862.

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Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription regulators. Data here reported show that inhibition of PARP activity allows the diffuse insertion of methyl groups onto some CpG islands and in particular on the CpG island which is located in the promoter region of Dnmt1 gene. Hence, following inhibition of PARPs activity, this promoter loses its protection against methylation becoming silence
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30

Lau, Ho-Tak. "Transcriptional and post-transcriptional control of DNMT1 in oocytes and somatic cells." Thesis, University of Ulster, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554332.

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In mammals, the DNA methylation patterns are established by the de novo methyltransferases of the DNMT3 family and subsequently maintained DNMTl. The DNA methylation patterns of imprinted genes are established during gametogenesis. Many imprinted genes are found methylated on the maternal allele, and this modification is established during oocyte growth. My primary aim was to develop a simple in vitro system for culturing oocytes during the period of de novo methylation, which would allow us to access this critical developmental period and to manipulate the microenvironment by supplementing gr
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Rutledge, Charlotte Emily. "Investigating the transcriptional control of Dnmt3L and post-transcriptional control of Dnmt1." Thesis, University of Ulster, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589755.

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In this thesis I present an investigation into mechanisms which regulate the expression of the DNA methyltransferase family members DNMT3L (a co-factor for de novo methylation) and DNMTl (the maintenance methyltransferase). I present work demonstrating the involvement of DNA methylation in the regulation of expression of DNMT3L from one of its three promoters, and also show that DNMT3L itself is required for this methylation to occur in murine oocytes. Furthermore, the data demonstrates that DNMT3L is required not only for DNA methylation of imprinted sequences in murine oocytes, as was previo
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Jurkowska, Renata Zofia [Verfasser]. "Biochemical characterization of the mammalian Dnmt3 family of DNA methyltransferases / Renata Zofia Jurkowska." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2009. http://d-nb.info/1034984969/34.

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Wu, Bo-Kuan. "Intrinsic and extrinsic regulation of DNA methylation during malignant transformation." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1419.

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Cytosine methylation of CpG dinucleotides is an epigenetic modification that cells use to regulate gene expression, largely to promote transcriptional silencing. Focal hypermethylation of tumor suppressor genes (TSGs) accompanied by genomic hypomethylation are epigenetic hallmarks of malignancy. DNA methyltransferase 1 (DNMT1) is the principle vertebrate enzyme responsible for maintenance of DNA methylation and its dysregulation has been found to lead to aberrant methylation in cancer. In addition, recent findings demonstrated that the ten-eleven translocation 1 (TET1) protein functions as a 5
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34

Zepper, Matthias Lutz [Verfasser], and Frank [Akademischer Betreuer] Rosenbauer. "Epigenetic characterization of murine Dnmt1-deficient MLL-AF9 leukemia : DNA-methylation in large regions and at cis-regulatory elements dissected in the Dnmt1 -/chip mouse model / Matthias Lutz Zepper ; Betreuer: Frank Rosenbauer." Münster : Universitäts- und Landesbibliothek Münster, 2020. http://d-nb.info/1211670813/34.

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Rottach, Andrea. "Analysis of the cell cycle dependent dynamics of Dnmt1 and Np95 in living cells." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-110219.

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Höche, Alexander [Verfasser]. "Expressionsanalyse der DNA-Methyltransferasen DNMT1 und DNMT3b bei akuten Leukämien im Kindesalter / Alexander Höche." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/103038097X/34.

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Ulian, Benitez Suzana. "Function of Kek-6 and DNT2 in structural synaptic plasticity in Drosophila." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8440/.

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The Drosophila nervous system undergoes structural synaptic plasticity, however, the mechanisms that govern such event are little understood. Structural synaptic plasticity in mammals is regulated by the neurotrophin brain derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase full length (TrkB-FL). TrkB-FL has a tyrosine kinase domain (TyrK) intracellularly, that is required for its function in structural synaptic plasticity. Trk receptors have long been sought in Drosophila to verify mechanisms of structural synaptic plasticity, but they have not been found. Later,
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Viziteu, Elena. "RECQ1 Helicase Involvement in the Resistance to Replication Stress and Chemotherapy in Multiple Myeloma Myélome Multiple." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT008.

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Le myélome multiple (MM) est une néoplasie B caractérisée par l’accumulation d’un clone plasmocytaire dans la moelle osseuse. Des études ont démontré que les modifications épigénétiques comme la méthylation de l’ADN jouent un rôle dans la régulation d’expression de différents gènes associés au cancer. Dans une étude récente, nous avons pu décrire un score génique de méthylation de l’ADN permettant de prédire la sensibilité des cellules de MM aux inhibiteurs de DNMT (DNA methyltranfexrase) (Moreaux, et al 2012). Parmi les gènes dont l’expression est inhibée par les inhibiteurs de DNMT et associ
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Menon, Yoann. "Etude des effets pharmacologiques d'inhibiteurs non nucléosidiques de la méthylation de l'ADN." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30004/document.

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Les modifications épigénétiques participent au contrôle de l'expression génique. Il a été montré que la méthylation des désoxycytidines (dC) de l'ADN joue un rôle clé dans la régulation épigénétique chez les mammifères. Cette modification correspond à la marque épigénétique la plus stable. Elle a lieu sur des résidus CpG regroupés en ilôts, essentiellement situés au niveau des séquences promotrices, des séquences répétées et des séquences encadrants les ilôtsCpG. L'hyperméthylation des promoteurs induit une inhibition de l'expression des gènes, tandis qu'une hypométhylation est associée à une
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De, Vos Mike. "Interaction fonctionnelle de la Poly(ADP-Ribose) polymérase-1 (PARP1) avec des protéines de l'hétérochromatine : impact sur la fonction de l'hétérochromatine et la réparation de l'ADN." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ001.

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Nous avons identifié une association poly(ADP-ribose) (PAR)-dépendante entre PARP1 et UHRF1. UHRF1 est PARylé par PARP1 et lie le PAR de façon non covalente. L’absence de PARP1 (i) perturbe l’association de UHRF1 et DNMT1, (ii) induit une ubiquitination excessive de DNMT1 par UHRF1 favorisant sa dégradation au cours du cycle, (iii) favorise la transcription des régions de l’hétérochromatine péricentrique (pHC) (iv) et perturbe la localisation de la marque répressive H4K20me3 au niveau des foyers de l’pHC. Dans un deuxième temps, nous avons étudié le rôle de l’association KAP1-HP1 dans la répon
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41

Shock, Lisa. "Functional consequences of cytosine methylation in mitochondrial DNA catalyzed by DNA methyltransferase 1." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/271.

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Cytosine methylation of mitochondrial DNA (mtDNA) was first described several decades ago, but neither the mechanism generating this modification nor its functional significance was known. Because mitochondrial dysfunction is a hallmark characteristic of numerous human diseases, including neurological and cardiovascular disease, aging and cancer, this dissertation addressed whether epigenetic modification of mtDNA regulates mitochondrial function. We show that mtDNA contains not only 5-methylcytosine (5mC), but also 5-hydroxymethylcytosine (5hmC), suggesting that previous reports likely undere
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Maciel, Izaque de Sousa. "Envolvimento do óxido nítrico na metilação do DNA induzida por estresse." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-25072018-094208/.

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A exposição ao estresse induz um aumento dos níveis de óxido nítrico (NO) e glutamato em estruturas do cérebro de ratos, as quais estão relacionadas com o transtorno de depressão maior (DM) em humanos. Ademais, o estresse está diretamente relacionado com o aumento da metilação do DNA, uma alteração epigenética repressiva, no hipocampo de animais. Estudos anteriores demonstraram o efeito tipo antidepressivo dos inibidores da enzima óxido nítrico sintase (NOS) em animais submetidos ao estresse. Porém não se sabe se há uma relação entre o aumento do NO e glutamato induzido pelo estresse e alteraç
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43

Aguirre-Arteta, Ana Maria. "Regulation of DNA methylation during development." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2000. http://dx.doi.org/10.18452/14509.

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Die DNA Methyltransferasen sind verantwortlich für die spezifische Methylierung von DNA-Basen. Mehrere DNA Methyltransferasen sind bekannt, wobei die Dnmt1 das hauptsächlich vorkommende Enzym ist. Bei Säugetieren korreliert die DNA-Methylierung mit der Genaktivität und ist essentiell für die Embryonalentwicklung. Eine beeinträchtigte Funktion oder Verfügbarkeit des Enzyms kann zu pathologisch veränderten Zuständen führen. Die Regulation der Dnmt1 und die damit verbundene Bedeutung bei der Entstehung von Krankheiten ist bisher nur unvollständig untersucht. In der Frühphase der Embryonalentwickl
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44

Dudley, Kevin. "The role of DNMT1 inhibition in the identification of epigenetically silenced genes in pituitary tumours." Thesis, Keele University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493649.

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Epigenetic unmasking, either by pharmacological inhibition or direct gene targeting, has been utilised to identify novel tumour suppressor genes that are silenced in association with inappropriate CpG island (CGI) methylation in various types of cancer. In this study, an epigenetic unmasking strategy was developed to identify novel genes that are silenced in association with inappropriate, CGI methylation in pituitary tumours.
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45

Moreno, Daniel Antunes. "Estudo da Expressão dos Genes DNMT1, DNMT3A, DNMT3B, MGMT e Efeitos da Zebularina em Glioblastoma." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-102215/.

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Os gliomas são tumores que surgem a partir de células da glia e são considerados os mais comuns do sistema nervoso central. São subdivididos em quatro grupos: astrocitoma pilocítico (grau I), astrocitoma difuso (grau II), astrocitoma anaplásico (grau III) e glioblastoma (grau IV ou GBM). Entre esses, o GBM é o tumor mais agressivo e mais freqüente. Apesar de ser encontrado em qualquer faixa etária, esse tumor é raro em crianças. Atualmente a cirurgia seguida de radioterapia e quimioterapia com temozolomida (TMZ) tem sido utilizado como protocolo de tratamento padrão para a maioria dos p
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46

SONCINI, MATIAS CRISTOBAL. "Epigenetic therapies for acute myeloid leukemias : pre-clinical validation and study of molecular mechanisms." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/56628.

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Epigenetic therapies of cancer have been intensely studied, because of the high frequency of epigenetic alterations found in tumor cells. Epigenetic modulators, such as histone deacetylases (HDAC) and DNA methyltransferase (DNMT), can be targeted by specific drugs with the intent to revert the epigenetic alterations induced by tumor progression. Although a few DNMT inhibitors have been approved for the therapy of some specific hematopoietic diseases, most of the results of clinical trials on other types of cancer have given limited results. The need for a better understanding of the molecular
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47

Saidj, Djamel. "Alteration of p53 and NF-kB pathways by E7 protein from cutaneous Human Papillomavirus type 38." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10237/document.

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Les infections virales sont responsables de 15 à 20 % des cancers humains. L étude des mécanismes moléculaires avec lesquels les virus oncogènes induisent la transformation cellulaire est essentielle pour la compréhension des cancers qui en résultent. Cela permettra également la découverte de nouveaux mécanismes pouvant être impliqués dans le développement de cancers, qui peuvent être ciblés par des approches thérapeutiques. Les virus du papillome humain (HPV) sont des petit virus à ADN qui futs isolés de la peau de patients souffrants de Epidermodysplasia Verruciformis (EV) qui cause un risqu
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48

Sakamoto, Hiromasa. "Functional and genomic characterization of patient-derived xenograft model to study adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263350.

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49

BARRA, Viviana. "DNMT1 SILENCING ELICITS DIFFERENT CELL CYCLE RESPONSES IN PRIMARY VERSUS TUMOR CELLS AND IS ASSOCIATED WITH ANEUPLOIDY GENERATION." Doctoral thesis, Università degli studi di Palermo, 2011. http://hdl.handle.net/10447/95092.

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50

Dahlet, Thomas. "Méthylation de l'ADN : fonctions et ciblage au cours du développement chez la souris." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ075.

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La méthylation des cytosines est une modification épigénétique catalysée par la famille des ADN méthyltransférases (DNMTs). C’est une marque répressive lorsqu’elle est adressée sur les îlots CpG des promoteurs de gènes. Le développement embryonnaire murin est caractérisé par une reprogrammation de la méthylation de l’ADN qui est critique pour le développement de l’embryon. Cependant, la contribution des différentes DNMTs dans la méthylation du génome ainsi que les mécanismes qui ciblent la méthylation de l'ADN vers certains gènes durant le développement embryonnaires son
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