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Dissertations / Theses on the topic 'Docetaxel resistance'

Author: Grafiati

Published: 2 November 2024

Last updated: 31 July 2025

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1

Sangrithi-Wallace, Jay N. "An investigation of the molecular mechanisms of docetaxel resistance in breast cancer cells." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=56251.

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Kastl, Lena. "Molecular mechanisms of docetaxel resistance in breast cancer." Thesis, University of Aberdeen, 2007. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158488.

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Docetaxel is a chemotherapy drug used to treat breast cancer, however as with many chemotherapeutic drugs, resistance commonly occurs and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulatory mechanisms like DNA methylation, histone deacetylation and miRNA expression have been shown to play an important role in cancer drug resistance. This study investigated the role of these mechanisms in two in vitro breast cancer cell line models (MCF-7 and MDA-MB-231) of acquired docetaxel resistance. Using inhibitors to DNA methylation and histone deacetylation,

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McDonald, Sarah L. "Characterization of genetic events involved in docetaxel resistance in breast cancer." Thesis, University of Aberdeen, 2005. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU487906.

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A model of docetaxel resistance in breast tumours was established in two breast cancer cell lines MCF-7 and MDA-MB-231. This was the first description of docetaxel resistant breast cancer cell lines. As an initial global analysis of the genetic events involved in docetaxel resistance, comparative genomic hybridisation (CGH) was used on the DNA extracted from the resistant cell compared to the parental cells. This allowed a unique insight into the specific chromosomal regions that were modified as resistance to docetaxel developed. The resistant cells exhibited a variety of chromosomal modifica

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Darcansoy, Iseri Ozlem. "Investigation Of Docetaxel And Doxorubicin Resistance In Mcf-7 Breast Carcinoma Cell Line." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610422/index.pdf.

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Multidrug resistance phenotype of tumor cells describes resistance to wide range of structurally unrelated anticancer agents and is a serious limitation to effective chemotherapy. It is a multifactor yet not fully elucidated phenomenon by the involvement of diverse cellular pathways. Aim of this study was to investigate the resistance mechanisms developed against docetaxel and doxorubicin that are widely used in the treatment of breast cancer in model cell line MCF-7. Resistant sublines were developed by application of drugs in dose increments and effect of docetaxel and doxorubicin on drug

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5

Pruitt, Freddie Lee III. "Chemoresistance of prostate cancer cells to docetaxel is modified by extracellular matrix substratum." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 92 p, 2008. http://proquest.umi.com/pqdweb?did=1459903001&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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6

IPPOLITO, LUIGI. "OXPHOS - a metabolic switch driven by tumor microenvironment and resistance to therapy in prostate carcinoma." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1006820.

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Tumor cells exhibit metabolic reprogramming according to microenvironmental scenarios (i.e. stroma composition and/or anticancer drugs burden) to meet their demands for energy, rapid proliferation, metastasis and progression. In our experimental model, a vicious metabolic synergy between CAFs and prostate cancer (PCa) cells has been described as a pivotal engine allowing cancer cells to achieve aggressive features and evolve their malignancy. Such metabolic crosstalk is mainly based on the OXPHOS rewiring of PCa cells induced by highly glycolytic CAFs through the establishment of tumor:

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Al, Nakouzi Nader. "Etablissement d'un nouveau modèle pérclinique de cancer de la prostate et identification de biomarqueurs de résistance au docetaxel." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00739261.

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La mise au point de modèles de laboratoire est d'une importance cruciale pour comprendre la biologie du cancer de la prostate, ainsi que pour évaluer les nouveaux traitements. Le développement de tels modèles est particulièrement difficile et reste à ce jour insuffisant car la majorité de ces modèles est d'origine métastatique ou obtenu in vitro d'une façon artificielle. C'est pourquoi, nous avons entrepris au laboratoire, l'établissement de nouveaux modèles à partir d'un cancer primaire de prostate tumorale et obtenu la lignée IGR-CaP1. La lignée IGR-CaP1 constitue un modèle adapté pour étudi

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RIZZUTI, ILARIA FRANCESCA. "STRENGTHEN OF DPNS FEATURES FOR THERANOSTIC APPLICATIONS AND MECHANICAL-CONTROL OF CHEMOTHERAPEUTIC EFFICACY THROUGH MODULATION OF CELL PROLIFERATION." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1000310.

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Solid tumors are complex biological structures which are composed of cellular and matrix components, everything being perfused by blood vessels. During tumor development, modifications of both biochemical and mechanical parameters are observed and can feedback on one another. Cancer cells constantly interact with their mechanical environment and the whole tissue is mostly confined by its surrounding. Compressive mechanical stress develops in part from cell proliferation and could eventually result in the clamping of blood vessels leading to increased interstitial fluid pressure (hydrostatic pr

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9

Len, Kateryna. "Vitamin D effects on prostate cancer progression." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ028.

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Le cancer de la prostate (CaP) est l’un des cancers le plus mortel chez les hommes. Le CaP avancé est traité avec les inhibiteurs du récepteur des androgènes ou la chimiothérapie (chimiothérapie), mais la plupart des patients développent des résistances. Ainsi, des nouvelles stratégies thérapeutiques sont nécessaires pour améliorer la prise en charge du CaP. Les faibles niveaux circulants de la vitamine D ou de son récepteur VDR dans les cellules épithéliales prostatiques (PECs) sont corrélés avec la gravité du CaP, mais le mécanisme sous-jacent n'est pas décrit. Cette étu

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10

Hou, Pei-Shen, and 侯佩伸. "Molecular mechanisms of AMPK mediated docetaxel-resistance in human prostate cancer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/69158788833945408088.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>105<br>Docetaxel is the first-line chemotherapeutic agent for patients with castration resistant prostate cancer (CRPC). Unfortunately, clinical treatment with docetaxel often encounters a number of undesirable side effects, including drug resistance. AMP-activated protein kinase (AMPK) is the cellular energy sensor, which can regulate metabolism and maintain energy homeostasis involving glycolysis. Recently, we found AMPK was associated with the development of docetaxel resistance in PC. However, the mechanisms of AMPK-mediated docetaxel-resistance in PC were remai

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11

AlQutub, Alaa Waleed. "Bone microenvironment - mediated cancer cell dormancy, dissemination, and drug resistance." Thesis, 2018. https://hdl.handle.net/2144/31252.

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OBJECTIVE: To determine the effect of clinically used zoledronate (ZOL) and docetaxel on breast cancer cells and bone biology under both bone remodeling stages and the rate of tumor dissemination and state of dormancy. METHODS: The effect of clinically used zoledronate (ZOL) was examined on MDA-MB-231 and MDA-BO cells in a roller tube system under bone resorption and formation conditions. Three groups; calvaria alone, calvarial co-cultured with tumor cells, and calvaria with tumor cells treated with four repeat doses of 2 µM of ZOL were cultured for 8, 14 and 20 days. The formation groups wer

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12

Fonseca, Pedro Miguel Borges. "Prostate cancer exosomes as molecular predictors of response to therapy." Master's thesis, 2015. http://hdl.handle.net/10362/17910.

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Prostate cancer is the second most common cancer in men and acording to the Globocan report from 2012, there will be over 1.2 million new cases and over 300 000 deaths, worldwide. Organ-defined prostate cancer is a curable disease, but then it develops into metastatic castration resistant prostate cancer, and it is usually a matter of time until the patient develops resistance to chemotherapy and becomes an incurable disease. This evokes the need for biomarkers that can predict disease progression and response to therapy. This would allow for a better stratification of the patients to re

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13

Chung, Shu-Ju, and 莊淑茹. "Molecular mechanisms of human Docetaxel-resistant prostate cancer cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/96005963391172517892.

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碩士<br>高雄醫學大學<br>生物化學研究所<br>97<br>Clinically, for metastatic prostate cancer who received hormone therapy can improve symptoms, but most patients die in a few years after the recurrence of hormone-resistant prostate cancer, recent studies found that docetaxel-based therapy can significantly extend the survival time of patients, but the use of docetaxel treatment after a period of time often caused by drug-resistant.This study hopes to explore through the docetaxel-resistant prostate cancer have a mechanism with a view to identify the future policy of the treatment. First, we establishment of a

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14

Yu-Chen and 邱于禎. "Study the Alimta sensitivity in Docetaxel resistant lung cancer cell." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/24746739138607485720.

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碩士<br>中山醫學大學<br>醫學研究所<br>99<br>Lung cancer is the leading cause of death worldwide from all cancers, and chemotherapy is the common treatment for lung cancer patients. The development of drug resistance is the single most important cause of treatment failure in patients with chemotherapy. When patients become resistant to chemotheraputic drugs, it is commonly developed cross-resistance to other anti-cancer drugs. In previous experiments, we have used A549 cells to select docetaxel resistant cell lines and two sublines of A549/D16 and A549/D32 were established. We have found these two sublines

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15

Wu, Hong-Lin, and 吳竑麟. "Chemoresistant Role of Acetyl-tubulin in Docetaxel-Resistant Prostate Cancer Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/21810892613095378711.

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碩士<br>高雄醫學大學<br>生物化學研究所<br>99<br>Docetaxel-based chemotherapy has generally been considered as one of the effective treatments for prostate cancer. Unfortunately, clinical treatment with docetaxel often encounters a number of undesirable side effects, including drug resistance. Therefore, it has become essential to identify molecular events that may be associated with the development of docetaxel resistance. Tubulin isoforms have been previously examined for their resistant ability to docetaxel in many cancers, but the real mechanisms remained unclear. In this study, we evaluated the feasibili

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16

Liao, Chih-Kang, and 廖致綱. "Chemoresistant Mechanism of Interleukin-8 in Docetaxel-Resistant Prostate Cancer Cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/05821397661199501597.

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碩士<br>高雄醫學大學<br>生物化學研究所<br>101<br>Hormone therapy for hormone-sensitive prostate cancer patients slows down the growth of the cancer for few years but it will finally turn into castration-resistant prostate cancer (CRPC). The chemotherapeutic agent docetaxel has been used as a prostate chemotherapy drug for years. Significant outcome has been observed in CRPC patients, but for the most part them will ultimately get docetaxel resistant cancer. Without any widely-used or promoted clinical drug for docetaxel resistant patients, to find the mechanism behind the drug resistance has become imperativ

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17

Lin, Zih-Yao, and 林子堯. "Investigation of the mechanism of Pemetrexed sensitivity in Docetaxel-resistant lung cancer cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/30996058529106438952.

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碩士<br>中山醫學大學<br>醫學研究所<br>103<br>Chemotherapy is the common treatment for lung cancer patients. The development of drug resistance is the most important cause of treatment failure. When cancer resistant to chemotheraputic drugs, it is commonly developed cross-resistance to other anti-cancer drugs. In previous experiments, we have used docetaxel to select A549 cells and two sublines of A549/D16 and A549/D32 have been established. We have found these two sublines were more sensitive to Alimta than the parental A549 cells. Therefore, we plan to further characterize the mechanism of Alimta sensitiv

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18

Chang, Hsi-Wen, and 張喜雯. "Molecular role of EGFR and interleukin-8 related migration in docetaxel-resistant prostate cancer cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/41113753848072293683.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>105<br>In clinical, docetaxel is used in the first-line treatment for patients with castration‑resistant prostate cancer （CRPC）, significantly extended overall survival of patients. However, the treatment is usually limited when gradual development of docetaxel-resistance. It has become imperative and important to find the mechanism of the docetaxel-resistance in prostate cancer. In previous studies have suggested that epidermal growth factor receptor （EGFR） and Interleukin-8 （IL-8） are required for prostate cancer progression and drug resistance. The molecular mec

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19

Fu, Yu-Ke, and 傅榆格. "Suppressive effect of Caffeic Acid Phenethyl Ester on proliferation and survival of docetaxel-resistant prostate cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/t294qm.

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20

Rodrigues, Catarina Isabel Dantas de Brito. "Metastatic castration - resistant prostate cancer patients - predictive factors of response to rechallenge with docetaxel / Artigo de investigação médica." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/81702.

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21

Rodrigues, Catarina Isabel Dantas de Brito. "Metastatic castration - resistant prostate cancer patients - predictive factors of response to rechallenge with docetaxel / Artigo de investigação médica." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/81702.

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22

Chen, Yi-Pei, and 陳羿霈. "A Novel Quinoline Derivative Induced Intrinsic Apoptotic Pathway and Intra-S Phase Arrest in Docetaxel-Resistant Prostate Cancer Cell." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/37413220049484433257.

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碩士<br>高雄醫學大學<br>香粧品學系碩士班<br>105<br>In this study, BV001 is a new synthetic quinoline derivative with the cytotoxic effects in prostate cancer(PCa) cells. BV001 has been found to have the anti-proliferation in PCa cell lines(PC3 and PC/DX25) by arresting cell cycle in intra-S phase. Nowadays, the docetaxel-base therapies are used as a first-line chemotherapy for castration-resistant prostate cancer(CRPC) patients. However, almost all patients died from docetaxel-resistant CRPC during three to five months. Hence, the development of effective chemotherapeutic agents for CRPC patients has become i

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23

Lahcene, Halima. "Cancer de la prostate résistant à la castration métastatique : utilisation des nouveaux traitements dans un contexte réel au Québec." Thèse, 2017. http://hdl.handle.net/1866/19454.

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