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Journal articles on the topic 'Doebner synthesis'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Peyrot, Cédric, Matthieu M. Mention, Robin Fournier, et al. "Expeditious and sustainable two-step synthesis of sinapoyl-l-malate and analogues: towards non-endocrine disruptive bio-based and water-soluble bioactive compounds." Green Chemistry 22, no. 19 (2020): 6510–18. http://dx.doi.org/10.1039/d0gc02763d.

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2

Zacuto, Michael J. "Synthesis of Acrylamides via the Doebner–Knoevenagel Condensation." Journal of Organic Chemistry 84, no. 10 (2019): 6465–74. http://dx.doi.org/10.1021/acs.joc.9b00450.

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3

Zhang, Z. P., L. M. V. Tillekeratne, and Richard A. Hudson. "An unusual product in a Doebner-von Miller quinoline synthesis." Tetrahedron Letters 39, no. 29 (1998): 5133–34. http://dx.doi.org/10.1016/s0040-4039(98)01008-9.

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4

Ghosh, Suman Kr, and Rajagopal Nagarajan. "Total synthesis of actinophenanthroline A via double Doebner–Miller reaction." Tetrahedron Letters 57, no. 36 (2016): 4009–11. http://dx.doi.org/10.1016/j.tetlet.2016.06.045.

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5

N., G. Salunkhe, V. Thakare N., A. Ladole C., and S. Aswar A. "Green synthesis of quinoline-4-carboxylic acid derivatives using silica sulfuric acid as an efficient catalyst." Journal of Indian Chemical Society Vol. 92, Aug 2015 (2015): 1295–98. https://doi.org/10.5281/zenodo.5599012.

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Department of Chemistry, Sant Gadge Baba Amravati University, Amravati-444 602, Maharashtra, India <em>E-mail</em> : aswaranand@gmail.com <em>Manuscript received online 22 October 2014, accepted 16 December 2014</em> Quinoline-4-caboxylic acid derivatives were synthesized in moderate to high yields via one-pot three components Doebner reaction of pyruvic acid, aldehydes and anilines in the presence of silica sulfuric acid as an efficient catalyst, under very mild conditions with excellent yields. The notable advantages of this protocol are work-up procedure is easy and the catalyst can be reco

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6

Halim, Ayu Mutmainnah, Antonius Herry Cahyana, and Rika Tri Yunarti. "One-Pot Synthesis of 2-Phenylquinoline-4-Carboxylic Acid: Iron(III) Trifluoromethanesulfonate Catalysed Doebner Reaction." Key Engineering Materials 907 (January 21, 2022): 97–102. http://dx.doi.org/10.4028/www.scientific.net/kem.907.97.

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Iron (III) trifluoromethanesulfonate [Fe (OTF)3] has been proven to be an effective catalyst in the synthesis of 2-phenylquinoline-4-carboxylic acid by the Doebner reaction using one-pot pyruvic acid, aniline, and benzaldehyde. This method shows attractive characteristics including concise one-pot conditions, high atom economy, very limited energy consumption, and the sequential catalytic process requires only a catalytic (15 mol%) amount of Fe (OTf)3 with short reaction periods (3 h) . Meanwhile, the catalyst was easily recovered from the reaction system and reused smoothly with only a little

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7

Denmark, Scott E., and Srikanth Venkatraman. "On the Mechanism of the Skraup−Doebner−Von Miller Quinoline Synthesis." Journal of Organic Chemistry 71, no. 4 (2006): 1668–76. http://dx.doi.org/10.1021/jo052410h.

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8

Matsugi, Masato, Fujio Tabusa, and Jun-ichi Minamikawa. "Doebner–Miller synthesis in a two-phase system: practical preparation of quinolines." Tetrahedron Letters 41, no. 44 (2000): 8523–25. http://dx.doi.org/10.1016/s0040-4039(00)01542-2.

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9

ZHANG, Z. P., L. M. V. TILLEKERATNE, and R. A. HUDSON. "ChemInform Abstract: An Unusual Product in a Doebner-von Miller Quinoline Synthesis." ChemInform 29, no. 40 (2010): no. http://dx.doi.org/10.1002/chin.199840112.

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10

Rioux, Benjamin, Cédric Peyrot, Matthieu M. Mention, Fanny Brunissen, and Florent Allais. "Sustainable Synthesis of p-Hydroxycinnamic Diacids through Proline-Mediated Knoevenagel Condensation in Ethanol: An Access to Potent Phenolic UV Filters and Radical Scavengers." Antioxidants 9, no. 4 (2020): 331. http://dx.doi.org/10.3390/antiox9040331.

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p-Hydroxycinnamic diacids are reaction intermediates of the classical Knoevenagel–Doebner condensation between malonic acid and benzaldehydes. As they are generally obtained in low yields, they remain relatively under-studied and under-exploited. Herein, we developed and optimized a sustainable synthetic procedure allowing the production of these compounds in good to high yields (60–80%) using proline as the catalyst and ethanol as the solvent. Study of their antioxidant and anti-UV activities revealed that these p-hydroxycinnamic diacids were not only potent radical scavengers but also effici

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11

Ramann, Ginelle A., and Bryan J. Cowen. "Quinoline synthesis by improved Skraup–Doebner–Von Miller reactions utilizing acrolein diethyl acetal." Tetrahedron Letters 56, no. 46 (2015): 6436–39. http://dx.doi.org/10.1016/j.tetlet.2015.09.145.

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12

Loughlin, Wendy, Kristie Reynolds, and David Young. "Limitations of the ‘Two-Phase’ Doebner-Miller Reaction for the Synthesis of Quinolines." Synthesis 2010, no. 21 (2010): 3645–48. http://dx.doi.org/10.1055/s-0030-1258258.

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13

Hajalsiddig, Tawassl Tajelsir Hassan, and Ahmed Elsadig Mohammed Saeed. "Synthesis of new 6-substituent 2-phenyl and 2-(furan-2-yl)-3-phenyl-quinoline-4-carboxylic acid derivatives." European Journal of Chemistry 10, no. 1 (2019): 57–63. http://dx.doi.org/10.5155/eurjchem.10.1.57-63.1816.

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A synthesis of substituted quinolines has been achieved by the Doebner reaction which is a three component coupling of arylaldehyde, p-amino-acetophenone and phenyl pyruvic acid. The products of 2,3-diary-6-acetyl-quinoline-4-carboxylic acids were obtained by Claisen Schmidt condensation reaction with aldehydes in the presence of sodium hydroxide in order to give the corresponding α,β-unsaturated carbonyls. The substituted α,β-unsaturated carbonyls were condensed with urea, thiourea, hydrazine, phenyl hydrazine, semicarbazide hydrochloride and ethanolamine to synthesized 2-pyrimidinone, 2-pyri

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14

Matsugi, Masato, Fujio Tabusa, and Jun-ichi Minamikawa. "ChemInform Abstract: Doebner-Miller Synthesis in a Two-Phase System: Practical Preparation of Quinolines." ChemInform 32, no. 4 (2001): no. http://dx.doi.org/10.1002/chin.200104159.

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15

Khaligh, Nader Ghaffari, and Mohd Rafie Johan. "Recent Advances in the Nano-Catalytic Knoevenagel Condensation." Mini-Reviews in Organic Chemistry 17, no. 7 (2020): 828–42. http://dx.doi.org/10.2174/1570193x17666200102105440.

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&#945;,&#946;-Unsaturated acids are well-known and useful reagents, and they have been applied in different fields due to their fascinating properties. The catalytic Knoevenagel condensation reaction is one of the most remarkable methods for the formation of C=C bonds. The multi-substituted alkenes can be obtained from the reaction of carbonyl and active methylene compounds in the presence of base catalysts, Brönsted catalysts, Lewis acid catalysts, or ionic liquids. In terms of providing both desirable structural diversity and compound libraries, Doebner-Knoevenagel condensation is th

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16

Ramann, Ginelle A., and Bryan J. Cowen. "ChemInform Abstract: Quinoline Synthesis by Improved Skraup-Doebner-Von Miller Reactions Utilizing Acrolein Diethyl Acetal." ChemInform 47, no. 12 (2016): no. http://dx.doi.org/10.1002/chin.201612173.

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17

Gopaul, Kaalin, and Neil A. Koorbanally. "Synthesis and structure elucidation of a series of chloroquinoline-2-chalcones by the Doebner-Miller reaction." Magnetic Resonance in Chemistry 54, no. 8 (2016): 677–83. http://dx.doi.org/10.1002/mrc.4430.

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18

Wang, Li-Min, Liang Hu, Hong-Juan Chen, Yuan-Yuan Sui, and Wei Shen. "One-pot synthesis of quinoline-4-carboxylic acid derivatives in water: Ytterbium perfluorooctanoate catalyzed Doebner reaction." Journal of Fluorine Chemistry 130, no. 4 (2009): 406–9. http://dx.doi.org/10.1016/j.jfluchem.2009.01.002.

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19

Lüdtke, Carsten, Axel Haupt, Martin Wozniak, and Nora Kulak. "Synthesis of fluorine-containing 1,10-phenanthrolines using mild versions of Skraup and Doebner-von Miller reactions." Journal of Fluorine Chemistry 193 (January 2017): 98–105. http://dx.doi.org/10.1016/j.jfluchem.2016.11.016.

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20

Yang, Mingzhu, and Wenhua Ji. "Facile Synthesis of Quinolinecarboxylic Acid–Linked Covalent Organic Framework via One–Pot Reaction for Highly Efficient Removal of Water–Soluble Pollutants." Molecules 28, no. 9 (2023): 3752. http://dx.doi.org/10.3390/molecules28093752.

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To efficiently eliminate highly polar organic pollutants from water has always been a difficult issue, especially in the case of ultralow concentrations. Herein, we present the facile synthesis of quinolinecarboxylic acid-linked COF (QCA–COF) via the Doebner multicomponent reaction, possessing multifunction, high specific surface area, robust physicochemical stability, and excellent crystallinity. The marked feature lies in the quinolinyl and carboxyl functions incorporated simultaneously to QCA–COF in one step. The major cis–orientation of carboxyl arms in QCA–COF was speculated by powder X–r

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21

Shahi, Mahrzadi Noureen, Najma Perveen, Muhammad Naeem Khan, Samia Khakwani, and Misbahul Ain Khan. "Triazolopyrimidines: Synthesis of Aryl-1,2,4-triazolo[1,5-a]pyrimidines by Doebner-Miller Reaction and their Antibacterial Activity." Asian Journal of Chemistry 28, no. 12 (2016): 2665–69. http://dx.doi.org/10.14233/ajchem.2016.20058.

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22

Pan, Qian‐Wen, Jun‐Hu Wang, Qi Wang, Hui‐Jing Li та Yan‐Chao Wu. "Synthesis of 2‐Trifluoromethyl Quinolines from α,β‐Unsaturated Trifluoromethyl Ketones: Regiochemistry Reversal Comparing to the Standard Skraup‐Doebner‐Von Miller Synthesis". ChemistrySelect 5, № 13 (2020): 4099–103. http://dx.doi.org/10.1002/slct.202000895.

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23

Suresh, Dhruva Kumar, and Jagir S. Sandhu. "Bismuth(III) Chloride–Mediated, Efficient, Solvent-Free, MWI-Enhanced Doebner Condensation for the Synthesis of (E)-Cinnamic Acids." Synthetic Communications 40, no. 13 (2010): 1915–19. http://dx.doi.org/10.1080/00397910903162833.

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24

Kolb, Kenneth E., Kurt W. Field, and Paul F. Schatz. "A One-Step Synthesis of Cinnamic Acids Using Malonic Acid: The Verley-Doebner Modification of the Knoevenagel Condensation." Journal of Chemical Education 67, no. 12 (1990): A304. http://dx.doi.org/10.1021/ed067pa304.

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25

Yamashkin, S. A., and E. A. Oreshkina. "Traditional and modern approaches to the synthesis of quinoline systems by the Skraup and Doebner-Miller methods. (Review)." Chemistry of Heterocyclic Compounds 42, no. 6 (2006): 701–18. http://dx.doi.org/10.1007/s10593-006-0150-y.

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26

Sivaprasad, Ganesabaskaran, Rengasamy Rajesh, and Paramasivan T. Perumal. "Synthesis of quinaldines and lepidines by a Doebner–Miller reaction under thermal and microwave irradiation conditions using phosphotungstic acid." Tetrahedron Letters 47, no. 11 (2006): 1783–85. http://dx.doi.org/10.1016/j.tetlet.2006.01.034.

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27

Wu, Yan-Chao, Li Liu, Hui-Jing Li, Dong Wang та Yong-Jun Chen. "Skraup−Doebner−Von Miller Quinoline Synthesis Revisited: Reversal of the Regiochemistry for γ-Aryl-β,γ-unsaturated α-Ketoesters". Journal of Organic Chemistry 71, № 17 (2006): 6592–95. http://dx.doi.org/10.1021/jo060290n.

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28

Suresh, Suresh, Dhruva Kumar, and Jagir S. Sandhu. "ChemInform Abstract: Bismuth(III) Chloride-Mediated, Efficient, Solvent-Free, MWI-Enhanced Doebner Condensation for the Synthesis of (E)-Cinnamic Acids." ChemInform 41, no. 47 (2010): no. http://dx.doi.org/10.1002/chin.201047079.

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29

Augustine, John Kallikat, Yanjerappa Arthoba Naik, Ashis Baran Mandal, Nagaraja Chowdappa та Vinuthan B. Praveen. "gem-Dibromomethylarenes: A Convenient Substitute for Noncommercial Aldehydes in the Knoevenagel−Doebner Reaction for the Synthesis of α,β-Unsaturated Carboxylic Acids". Journal of Organic Chemistry 72, № 25 (2007): 9854–56. http://dx.doi.org/10.1021/jo701888m.

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30

Li, Pengyu, Liwei Mi, Yuanyuan Liu, Wenqin Zhang та Xian-Lei Shi. "Synergistic catalysis of bifunctional polyacrylonitrile fiber for the synthesis of (E)-α,β-unsaturated esters from aldehydes by decarboxylative Doebner–Knoevenagel reaction". Journal of Industrial and Engineering Chemistry 81 (січень 2020): 323–31. http://dx.doi.org/10.1016/j.jiec.2019.09.021.

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31

Sidler, Eric, Roger Humair, and Leo A. Hardegger. "Toward a Scalable Synthesis and Process for EMA401, Part II: Development and Scale-Up of a Pyridine- and Piperidine-Free Knoevenagel–Doebner Condensation." Organic Process Research & Development 24, no. 9 (2020): 1756–62. http://dx.doi.org/10.1021/acs.oprd.0c00216.

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32

Sinha, Arun K., Anuj Sharma, and Bhupendra P. Joshi. "One-pot two-step synthesis of 4-vinylphenols from 4-hydroxy substituted benzaldehydes under microwave irradiation: a new perspective on the classical Knoevenagel–Doebner reaction." Tetrahedron 63, no. 4 (2007): 960–65. http://dx.doi.org/10.1016/j.tet.2006.11.023.

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33

Heravi, Majid, Shima Asadi, and Fatemeh Azarakhshi. "Recent Applications of Doebner, Doebner-von Miller and Knoevenagel-Doebner Reactions in Organic Syntheses." Current Organic Synthesis 11, no. 5 (2014): 701–31. http://dx.doi.org/10.2174/1570179411666140426003616.

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34

Fotopoulos, Ioannis, Eleni Pontiki, and Dimitra Hadjipavlou Litina. "Targeting Inflammation with Conjugated Cinnamic Amides, Ethers and Esters." Letters in Drug Design & Discovery 17, no. 1 (2019): 3–11. http://dx.doi.org/10.2174/1570180816666181129125511.

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Background: Cinnamic acid is a key intermediate in shikimate and phenylpropanoid pathways. It is found both in free form, and especially in the form of esters in various essential oils, resins and balsams which are very important intermediates in the biosynthetic pathway of several natural products. The cinnamic derivatives play a vital role in the formation of commercially important intermediate molecules which are necessary for the production of different bioactive compounds and drugs. Different substitutions on basic moiety lead to various biological activities. Furthermore, combination of

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35

Heravi, Majid M., Shima Asadi, and Fatemeh Azarakhshi. "ChemInform Abstract: Recent Applications of Doebner, Doebner-von Miller and Knoevenagel-Doebner Reactions in Organic Syntheses." ChemInform 46, no. 14 (2015): no. http://dx.doi.org/10.1002/chin.201514309.

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36

Fotie, Jean, Hilaire V. Kemami Wangun, Katelyn Dreux, Thomas Sommerfeld, and Jacob Pittman. "Unusual open chain quinolinyl peroxol and its alcohol counterpart obtained through a modified Skraup-Doebner-Von Miller quinoline synthesis: theoretical studies and complete 1H- and 13C-NMR assignments." Magnetic Resonance in Chemistry 50, no. 1 (2012): 68–73. http://dx.doi.org/10.1002/mrc.3791.

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37

Digafie, Zeleke, Yadessa Melaku, Zerihun Belay, and Rajalakshmanan Eswaramoorthy. "Synthesis, Antibacterial, Antioxidant, and Molecular Modeling Studies of Novel [2,3′-Biquinoline]-4-Carboxylic Acid and Quinoline-3-Carbaldehyde Analogs." Journal of Chemistry 2021 (April 30, 2021): 1–17. http://dx.doi.org/10.1155/2021/9939506.

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Currently, it has been common to see people being affected and dying from untreatable infections caused by multidrug-resistant (MDR) germs. To tackle this problem, developing new effective chemotropic agents is urgently needed. Hence, this project aims to design, synthesize, and evaluate their antibacterial and antioxidant activities of new series of [2,3′-biquinoline]-4-carboxylic acid and quinoline-3-carbaldehyde analogs. The molecular docking analysis of the compounds against E. coli DNA gyrase was computed to investigate the binding mode of the compounds within the active site of the enzym

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38

Rafique, Iqra, Tahir Maqbool, Floris P. J. T. Rutjes, Ali Irfan, and Yousef A. Bin Jardan. "Anti-Diabetic Activities and Molecular Docking Studies of Aryl-Substituted Pyrazolo[3,4-b]pyridine DerivativesSynthesized via Suzuki Cross-Coupling Reaction." Pharmaceuticals 17, no. 10 (2024): 1326. http://dx.doi.org/10.3390/ph17101326.

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Pyrazolo[3,4-b]pyridine scaffolds have been heavily exploited in the development of nitrogen-containing heterocycles with numerous therapeutic applications in the field of medicinal and pharmaceutical chemistry. The present work describes the synthesis of eighteen biaryl pyrazolo[3,4-b]pyridine ester (6a–i) and hydrazide (7a–i) derivatives via the Suzuki cross-coupling reaction. These derivatives were subsequently screened for their therapeutic potential to inhibit the diabetic α-amylase enzyme, which is a key facet of the development of anti-diabetic agents. Initially, the ethyl 4-(4-bromophe

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39

Javadi, Negar Moshref, та Javad Azizian. "One Pot Synthesis of 6-(4-carboxy-3-methyl-2-phenylquinolin-6-ylsulfonyl)-3-methyl-2-phenylquinoline-4-carboxylic Acids from Dapsone and α-ketobutyric Acid by a Doebner Reaction". Journal of Chemical Research 40, № 12 (2016): 715–17. http://dx.doi.org/10.3184/174751916x14785181796796.

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A series of new 6-(4-carboxy-3-methyl-2-phenylquinolin-6-ylsulfonyl)-3-methyl-2-phenylquinoline-4-carboxylic acids were synthesised by a one-pot reaction of dapsone, α-ketobutyric acid, and aromatic aldehydes in the presence of CuBr2 as a catalyst. Operational simplicity, mild reaction conditions, and eco-friendly procedure make this novel protocol a promising alternative for the preparation of quinoline-4-caboxylic acid derivatives. The structures of the products were established by elemental analyses and spectroscopic data. The biological activity of the new sulfone dimers was evaluated as h

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40

Fotie, Jean, Hilaire V. Kemami Wangun, Frank R. Fronczek, et al. "Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]quinolines from Skraup–Doebner–Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction." Journal of Organic Chemistry 77, no. 6 (2012): 2784–90. http://dx.doi.org/10.1021/jo202681r.

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41

Mitra, Alok Kumar, Aparna De, and Nilay Karchaudhuri. "Application of Microwave Irradiation Techniques for the Syntheses of Cinnamic Acids by Doebner Condensation." Synthetic Communications 29, no. 4 (1999): 573–81. http://dx.doi.org/10.1080/00397919908085805.

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42

Mitra, Alok Kumar, Aparna De, and Nilay Karchaudhuri. "ChemInform Abstract: Application of Microwave Irradiation Techniques for the Syntheses of Cinnamic Acids by Doebner Condensation." ChemInform 30, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199922091.

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43

Juristová, Nadežda, Eleonóra Štefanovová, Tatiana Ďurčeková, Naďa Prónayová, Anton Gatial, and Alžbeta Krutošíková. "Synthesis and reactions of [1]benzofuro[3,2-c]pyridine." Nova Biotechnologica et Chimica 7, no. 1 (2022): 107–14. http://dx.doi.org/10.36547/nbc.1366.

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(E)-3-(1-Benzofuran-2-yl)propenoic acid (I) was prepared from 1-benzofuran-2-carbaldehyde under the Doebner’s conditions. The obtained acid was converted to the corresponding azide II, which was cyclized by heating in diphenyl ether to [1]benzofuro[3,2-c]pyridin-1(2H)-one (III). This compound was aromatized with phosphorus oxychloride to chloroderivative IV which was reduced with zinc and acetic acid to the title compound V. [1]Benzofuro[3,2-c]pyridin-2-oxide (VI) was synthesized by reaction of V with 3-chloroperoxybenzoic acid in dichloromethane. Treatment VI with benzoyl chloride and potassi

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44

Eisch, John J., and Tomasz Dluzniewski. "Mechanism of the Skraup and Doebner-von Miller quinoline syntheses. Cyclization of .alpha.,.beta.-unsaturated N-aryliminium salts via 1,3-diazetidinium ion intermediates." Journal of Organic Chemistry 54, no. 6 (1989): 1269–74. http://dx.doi.org/10.1021/jo00267a010.

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45

Gao, Su-Fan, Xiao Fu, Qian-Mao Zhang, Ren-Zhi Tang, Wenjuan Wan, and Li-Xin Wang. "New Axially Chiral Biaryl Quinoline Ligands Specifically with AgOTf Enabled an Enantioselective Aza-Friedel Crafts Reaction." Organic & Biomolecular Chemistry, 2025. https://doi.org/10.1039/d5ob00231a.

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A new class of axially chiral biaryl pyridine ligands have been rationally designed and concisely prepared in two steps by Skraup-Doebner-Miller synthesis. Their proof-of-concept application in an enantioselective aza-Friedel Crafts...

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46

Ridder, Jared, null null, null null, null null, null null, and null null. "Model Studies of the Doebner Modified Knoevenagel Condensation." John Heinrichs Scholarly & Creative Activities Day, 2017. http://dx.doi.org/10.58809/ivya6891.

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Previous worksup1-6/sup on an initial model system for the synthesis of polyaromatic dyes for potential use in solar energy collection used the Doebner modified Knoevenagel condensation. This project is continuing the work on this approach to establish its viability.

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47

Sakhno, Yana, Oleksandr Radchenko, Vyacheslav Saraev, et al. "Temperature Controlled Diastereoselective Doebner / Ugi Tandem Reaction." SynOpen, May 11, 2023. http://dx.doi.org/10.1055/a-2091-7934.

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Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi-type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 °C to 45 °C. In most cases, the new method allowed each diastereomer to be isolated separately.

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48

Nycz, Jacek E., Marcin Szala, Jan Grzegorz Małecki, Maria Książek, and Joachim Kusz. "The Metal-Free Regioselective Deuteration of 2-Methylquinolin-8-ol and 2,5-Dimethylquinolin-8-ol, Spectroscopic and Computational Studies." Current Green Chemistry 10 (October 19, 2022). http://dx.doi.org/10.2174/2213346110666221019142941.

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Aim and background: Introducing deuterium to a molecule is of interest for a wide variety of research, including investigation of reaction mechanisms or kinetics, analysis of drug metabolism, structural elucidation of molecules, and syntheses of isotopically labeled materials used for NMR spectroscopy and medicinal research. Objective: The transition-metal-free regioselective deuteration of 2-methylquinolin-8-ol (1a) and 2,5-dimethylquinolin-8-ol (2a) with ambient reaction conditions and low-cost reagents is described in the paper. Methods: Regioselective H/D isotope exchange has been presente

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49

Panjacharam, Paranimuthu, and Sabbasani Rajasekhara Reddy. "Sustainable Strategy to Access Fused Chromenoquinoline Analogues via Doebner–Von Miller‐Type Reaction and Mechanistic Insights." Asian Journal of Organic Chemistry, July 9, 2025. https://doi.org/10.1002/ajoc.70106.

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AbstractIn this study, we report a metal‐ and oxidant‐free synthesis of fused chromenoquinolines via an acetic acid‐promoted Doebner–Von Miller‐type reaction. This effective method allows substituted anilines to react with 4‐chloro‐2H‐chromene‐3‐carbaldehydes in an eco‐friendly way, facilitating the formation of new C─N and C─C bonds while building fused polycyclic heteroaromatic rings. This protocol is broadly applicable for the synthesis of diverse 6H‐chromeno[4,3‐b]quinolines, which serve as versatile scaffolds for the subsequent cross‐coupling reactions and C(sp3)─H oxidation.

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Ghosh, Suman Kr, and Rajagopal Nagarajan. "ChemInform Abstract: Total Synthesis of Actinophenanthroline A via Double Doebner-Miller Reaction." ChemInform 47, no. 52 (2016). http://dx.doi.org/10.1002/chin.201652405.

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