Dissertations / Theses on the topic 'Dog breeds'
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Barroso, Maria Cristina Tenreiro Pereira Rodrigues. "Detection of the MDR1 mutation in Portuguese dog breeds." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/19292.
Full textP-glycoprotein is an ATP-driven drug efflux carrier, encoded by the multidrug resistance gene MDR1, also been referred as ABCB1, that is responsible for the transport of a broad variety of compounds, including drugs commonly used in veterinary medicine, out of the cell against the concentration gradient. The influence of P-gp on drug disposition has been demonstrated in Collies and in other herding dog breeds since a severe intoxication in response to treatment with the antiparasitic drug ivermectin and other avermectins has been reported in a subpopulation of these breeds. This adverse reaction is related to a 4-bp deletion in the ABCB1 gene. To our knowledge, no study was conducted in portuguese dog breeds to detect this gene mutation and there is no available information for the clinicians about this fact and consequently, about the safety of the administration of drugs that are P-gp substrates. Thus, it is important to know the status about the presence of MDR1 in dog breeds in Portugal. The main objective of this project was to implement the genetic test to identify the gene mutation on MDR1 gene and to perform this analysis in several animals from dog breeds in Portugal to obtain their MDR1 genotype. For that, we performed biological samples of saliva in animals from the dog breeds belonging to Group 1 and from the ones already identified as affected. The diagnosis technique used was adapted from the ones utilized by other authors, namely Mealy and collaborators. We analyzed 105 animals, 21.9% of which are Barbado da Terceira, 9.5% are Cão da Serra d’Aires, 52.4% belonging to breeds known to carry the mutation and 16.2% to other breeds. With this study we were able to establish the analysis in our laboratory, we identified the mutation in dogs of breeds already signalized as having the mutation and we evidenced that the mutation already is in Barbado da Terceira - carriers.
RESUMO - DETEÇÃO DA MUTAÇÃO MDR1 NAS RAÇAS CANINAS PORTUGUESAS - A glicoproteína P é um transportador dependente de ATP, codificado pelo gene de resistência a fármacos MDR1, também conhecido como ABCB1, que é responsável pelo transporte contra o gradiente de concentração (para o espaço extracelular) de vários substratos, incluindo fármacos comummente utlizados em Medicina Veterinária. A influencia deste transportador na reação a fármacos foi demonstrada em Collies e outras raças pastoras devido ao desenvolvimento de sinais neurológicos, de intoxicação grave, após o tratamento destes animais com antiparasitários do grupo das avermectinas, nomeadamente, a ivermectina. Esta reação está relacionada com a deleção de 4 pares de base no gene canino ABCB1, descoberta em 2001, em cães com fenótipo sensível à ivermectina. Até à data, não temos conhecimento de nenhum estudo feito em Portugal para detetar esta mutação genética e não existe informação disponível para os clínicos sobre este facto e, consequentemente, sobre a segurança de administração de medicamentos que sejam substratos da gp-P. É, por isso, importante saber-se o estatuto MDR1 em raças caninas em Portugal. O principal objetivo deste trabalho foi implementar o teste genético para identificação da mutação genética no gene MDR1 e realizar esta análise em vários exemplares de raças caninas em Portugal para obter o seu genótipo MDR1. Para o efeito foram realizadas colheitas de amostras biológicas de saliva em exemplares das raças caninas pertencentes ao grupo I e das raças já identificadas como afetadas. A técnica de diagnóstico utilizada foi adaptada das técnicas utilizadas por outros autores, nomeadamente Mealey e colaboradores. Foram analisados 105 animais, 21.9% dos quais são Barbados da Terceira, 9.5% são Cão da Serra d’Aires, 52.4% pertence a raças já identificadas como portadoras da mutação e 16.2% a outras raças. Com a realização deste estudo, conseguimos estabelecer a técnica no nosso laboratório, identificámos a mutação em cães de raças já sinalizadas como tendo a mutação e detetámos evidências que a mutação também circula na raça Barbado da Terceira - portadores.
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Packer, Rowena M. A. "Quantitative investigation of healthy conformational limits in domestic dog breeds." Thesis, Royal Veterinary College (University of London), 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618296.
Full textDoyle, Don Richard Lau Tin-Man. "Canine design creating the modern dog park /." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Spring/master's/DOYLE_DON_7.pdf.
Full textBrodd, Louise. "Behavioural differences between and within retriever breeds." Thesis, Linköpings universitet, Biologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133200.
Full textHuitson, Niki Rae. "An exploratory analysis of the emergence and implications of Breed Specific Legislation: knee-jerk reaction or warranted response? /." Burnaby B.C. : Simon Fraser University, 2005. http://ir.lib.sfu.ca/handle/1892/2361.
Full textAlcaraz, Rodríguez Patricia [Verfasser]. "Molecular genetic analysis of haemophilia A and B in several dog breeds / Patricia Alcaraz Rodríguez." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1029606641/34.
Full textKnowler, S. P. "Characterisation of chiari-like malformation and secondary syringomyelia in selected toy dog breeds using magnetic resonance imaging." Thesis, University of Surrey, 2017. http://epubs.surrey.ac.uk/844721/.
Full textMoioli, M. "APPEARANCE OF OSSIFICATION CENTERS OF THE LIMBS AND SKELETAL DEVELOPMENT IN NEWBORN TOY-DOG BREEDS: RADIOGRAPHIC, MORPHOMETRIC AND HISTOLOGICAL ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/233994.
Full textSerres, Armero Aitor 1992. "Understanding dog breed copy number differences in the framework of gray wolf copy number variation." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668662.
Full textThe study of structural variation complements and synergizes with the study of sequence variation to unravel the intricacies of phenotypic variation. Dogs are the most phenotypically variable domesticated species existing today despite their remarkably low nucleotide diversity. As such, the systematized study of copy number variation in an extensive panel of over 100 dog breeds has the potential to unravel a fraction of the bases of phenotypic diversity which remain unexplored. This study finds an excess of structural variants in dogs compared to the expectation given their genetic history, which can potentially account for some of their morphometric, anatomical and pathological variance. Indeed, trait mapping finds over 90 copy number variants associated with more than 10 phenotypes, some of which were previously unknown or uncharacterized. Moreover, there is a correlation between low effect, associated copy number variants and other relevant genomic features such as the expression patterns of long non-coding RNA or the presence of long-range chromatin contacts. Our characterization of copy number variation in dogs has generated a wealth of hypotheses for further functional testing and validation.
Comerford, Eithne Josephine. "Evaluation of extracellular matrix composition, metabolism, joint mechanics and joint conformation as potential predisposing factors of cranial cruciate ligament rupture in three dog breeds." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271882.
Full textAllaith, S. M. "Identifying of key proteoglycans in different anatomical regions of the canine cranial cruciate ligament from dog breeds at an altered risk to ligament disease and rupture." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3003228/.
Full textWagner, Franziska [Verfasser], Irina [Gutachter] Ruf, and Wolfgang [Gutachter] Oschmann. "Evolutionary transformations of the ethmoidal region in Canis lupus familiaris (Linné, 1758): effects of domestication on the turbinal skeleton in selected dog breeds / Franziska Wagner ; Gutachter: Irina Ruf, Wolfgang Oschmann." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1210555700/34.
Full textGrozelier, Anna. "Labrador and German shepherd breed differences in dog-human communication." Thesis, Linköpings universitet, Biologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119521.
Full textBradshaw, Yolonda F. "The Impact of Breed Identification, Potential Adopter Perceptions and Demographics, and Dog Behavior on Shelter Dog Adoptability." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619162805127048.
Full textDoehring, Orlando. "Identification of breed contributions in crossbred dogs." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464461/.
Full textvan, Boom Kathryn. "Skeletal muscle composition in various breeds of domestic dogs: (A comparative study)." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31125.
Full textKuhl, C. "An investigation of pedigree dog breeding and ownership in the UK : experiences and opinions of veterinary surgeons, pedigree dog breeders and dog owners." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/30548/.
Full textWinnerhall, Louise. "The effect of breed selection on interpreting human directed cues in the domestic dog." Thesis, Linköpings universitet, Biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108847.
Full textWanner, Christine Helen. "'For the good of the breed' : care, ethics, and responsibility in pedigree dog breeding." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23431.
Full textBobic, Gavrilovic Bojana. "Reproductive patterns in the domestic dog : a retrospective study, with the Drever breed as model /." Uppsala : Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/10639782.pdf.
Full textAngleby, Helen. "Analysis of domestic dog mitochondrial DNA sequence variation for forensic investigations." Licentiate thesis, Stockholm, Kungl. tekniska högskolan (KTH), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299.
Full textMazrier, Hamutal. "Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/12441.
Full textKristensen, Signe Frost. "Are mixed-breed dogs healthier than purebred dogs? A review of the current data on diseases and longevity in dogs." Thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-96779.
Full textI dagens värld har mer än 400 olika hundraser registrerats och antalet fortsätter att öka gradvis, eftersom människor kommer med nya sätt att avla hundar. Renrasiga hundar kan ha stora problem med ett flertal ärftliga störningar, inavelsdepression och en minskande gen pool. Å andra sidan sägs hundar med blandad ras vara mindre benägna för dessa problem, eftersom de har en högre genetisk variation. Denna översyn sammanfattar kunskap från de senaste 25 årens forskning inom området blandade hundar och renrasiga hundar för att se vad vi vet och vad vi fortfarande behöver undersöka ytterligare. Litteraturen är överens om att hundar med blandad ras har en ökad livslängd, även om andra faktorer avgör livslängder än rasen. De har också en minskad risk för några av de huvudsakliga sjukdomarna som organ defekter och cancer, dock kan de ha andra problem såsom brustet kranialkorsband, beteendeproblem som aggression, olyckor och diabetes, vilket påverkar livslängden. Framtida forskning måste ta hänsyn till det omvända förhållandet mellan kroppsmassa och livslängd vid mätning av livslängd mellan raser. Fler studier bör göras inom området cancer hos hundar, eftersom detta står för de flesta dödsfall totalt sett hos hundar.
Kopechek, Mary Elizabeth. "Variation in the Onset and Expression of Hazard Avoidance Behavior Across Three Breeds of Domestic dogs." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1268233077.
Full textTaylor, Robyn. "How does temperament and breed influence learned aversion training in domestic dogs." Thesis, Taylor, Robyn (2017) How does temperament and breed influence learned aversion training in domestic dogs. Honours thesis, Murdoch University, 2017. https://researchrepository.murdoch.edu.au/id/eprint/39794/.
Full textWickens, Stephen Michael. "Social relationships in the domestic dog (Canis familiaris) : the effect of learning and breed on behaviour within status relationships." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283381.
Full textKornberg, Krogh Linda. "When translators go barking up the wrong tree : A study of metaphor translation strategies in a dog breed book." Thesis, Linnéuniversitetet, Institutionen för språk (SPR), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-75906.
Full textBernardino, Filipa de Faria Pedro Verfasser], and Andrea [Akademischer Betreuer] [Fischer. "Investigation of an inherited cerebellar malformation in the Eurasier breed dog / Filipa de Faria Pedro Bernardino. Betreuer: Andrea Fischer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1078851875/34.
Full textBjörnerfeldt, Susanne. "Consequences of the Domestication of Man’s Best Friend, The Dog." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7799.
Full textSeefried, Franz Reinhold. "Genomic characterisation and polymorphism analysis of candidate genes for milk production traits and association studies in three cattle breeds." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/668346/668346.pdf.
Full textCandela, Andrade Mario [Verfasser]. "Patellar luxation and concomitant cranial cruciate ligament rupture in small breed dogs / Mario Candela Andrade." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/121092563X/34.
Full textBarjaktarevic, Cécile. "L'évaluation des actifs incorporels : le cas des marques et brevets." Paris 9, 1987. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=1987PA090071.
Full textTrade-marks and patents are particular assets which economic importance is considerable for a firm. Therefore, we can be astonished by the little interest the french firms take in them, and especually in patents. As assets, these elements have a value we need to determine, only in the case of an assignment, providing that accounting admits their existence only if they have been bought by the firm, but not created by it. Most of the valuation methods refer to the costs and not to the trade-marks' and patents'exploitation earnings. The royalty method is the only one which has a yield approach, and therefore is justified economically wise. However, it is scarcely applied by experts. We may wonder why? Based on a sample of trade-marks' and patents' licence contracts. This research shows the pervasive influence that the results' level has on the royalties' level, and consequentely on the assets' value level, which, as any other asset, is valuated from actualised forecasted yields
Jonikienė, Svetlana. "Mažųjų šunų veislės Lietuvoje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080317_132242-41115.
Full textMore and more people choose small dogs breeds, because these dogs perfectly suit for the small apartments. Lonely people choose small dog breeds as well – as a company, rat – catchers, instead of “door – bell“, or very often as an accessory. Yorkshire Terrier recently is one of the most popular dogs breeds in Lithuania. From 1992 till 11th of November, 2007 in the dogs breeds’ book in Lithuanian Cynological Society there were registered: 1045 Yorkshire Terriers,10 Australian Silky Terriers, 343 Russian Toy dogs (175 shorthaired and 168 longhaired ones), 275 Chihuahua (53 shorthaired and 222 longhaired ones). There was this number of breeding grounds registered till 11th of November, 2007: 66 of Yorkshire Terriers, 1 of Australian Silky Terriers, 25 of Russian Toy dogs (14 shorthaired and 11 longhaired), 22 of Chihuahua (5 shorthaired and 17 longhaired). Selecting and mating pedigree dogs it is very important to pay attention to their relationship. Mating relative dogs can have positive results to the population as well as negative ones. It can increase the proportion of homozygote having a required feature. A negative side is a possible increase of recessive diseases – inbreeding increase the possibility of homozygotism, and at the same time increase the possibility of diseases. In the investigated cases in two Estonian breeding grounds for Australian Silky Terriers, no relationship mating was found in the pedigree documents. Pedigree documents investigation was made in three... [to full text]
da, Cunha Daise Nunes Queiroz. "Properties of flow through the ascending aorta in boxer dogs with mild aortic stenosis momentum, energy, Reynolds number, Womersley's, unsteadiness parameter, vortex shedding, and transfer function of oscillations from aorta to thoracic wall /." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1243910694.
Full textFischer, Ida. "Does Lifestyle Affect the Attachment between Dogs, Canis familiaris, and Their Owner?" Thesis, Linköpings universitet, Biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148778.
Full textMartin, Vaquero Paula. "Cervical Spondylomyelopathy in the Great Dane Breed: Anatomic, Diagnostic Imaging, Functional, and Biochemical Characterization." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397420434.
Full textHagman, Ragnvi. "New aspects of canine pyometra : studies on epidemiology and pathogenesis /." Uppsala : Dept. of Small Animal Clinical Sciences, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/v182.pdf.
Full textKoplitz, Shianne L. "Investigation and assessment of ejection murmurs and the left ventricular outflow tract in Boxer dogs." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1123596533.
Full textStarr, Alison Nicole. "Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese." Thesis, [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2516.
Full textSundqvist, Anna-Karin. "Conservation Genetics of Wolves and their Relationship with Dogs." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8401.
Full textScherenberg, Abello Alexandra. "La licence de droits de propriété intellectuelle, fondement d’une circulation organisée des biens." Paris 9, 2006. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=2006PA090079.
Full textThe subject leads to a wonder about the legitimity of intellectual property rights in comparison with the principle of circulation, defined as the potential transfer of objects, of which one aspect at least is protected by an intellectual property right. The licence is a mode of transfer of the goods; therefore it is a vector of circulation. But it is more than that, because what it emphasizes is the availability of the good and not it’s appropriation. It is thus the base of a conception of intellectual property rights based on circulation. Consequently, the licence appears as a mechanism of regulation allowing the circulation of the goods. The relationship created by the licence agreement contribute to this objective of circulation because the licence is not only the suitable mode of exploitation of intellectual property’s multiple character but also the means of satisfying the licensor and the licensee multiple interests
Gaučas, Tadas. "PROBIOTIKŲ ĮTAKA SKIRTINGO DYDŽIO ŠUNIMS ĮVERTINANT MAISTO MEDŽIAGŲ PASISAVINAMUMĄ ORGANIZME BEI JŲ SVEIKATOS BŪKLĘ." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_142311-40533.
Full text“Beneficial” and probiotic bacteria became popular during the last decades. As it thought, the first scientist started these researches in this area was Russian scientist E. Mečnikov. At the beginning of the twentieth century, he stated that sour milk goods are very useful for health for their antagonistic effect to pathogenic bacteria in the large intestine. Also he stated that intestine micro flora of people and animals help to fight with infectious agents which get into the digestive tract. The aim of this study – to set influence of used natural probiotic for nutrient intake in organism of large, medium and small breed dogs, evaluating their state of health. Trying to implement tasks it was made three scientific tests and during them during appropriate periods – digestibility tests. Exploratory group – small breed dogs consumed 60.3 g dry full-rate food or 3.5 percent less (p<0.001) during the day; medium breed – 200.3 g or 2.6 percent; large breed – 530.3 g or 2.8 percent less compared with consumed amount of food of control dog group. Addition of yogurt had influence for humidity amount in excrements of dogs: in the composition of excrements of small breed dogs set 35.2 percent or 1.6 percent more (p<0.001); medium breed – 26.2 percent or 1.4 percent more (p<0.001); large breed – 24.2 percent or 1.6 percent more (p<0.001) dry matters compared with excrements of dogs, which did not get natural probiotic. In the organism of small breed dogs extra probiotic did not... [to full text]
Kuraitė, Aura. "ŠUNŲ BABEZIOZĖS GENETINIAI ASPEKTAI." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_142456-38086.
Full textGoal: to find out a variety of factors influence the occurrence of canine babesiosis, development, according to dog sex, age and breed, using known literature and personal research. The data were collected from „Jakovo veterinary center“, small animal clinic „pas Filą“ and the blood tests were collected and conducted at Veterinaty and Diagnostic center. We collected 1195 disease cases according to sex, age and breed. Anamnesis were collected from 117 dogs, morphological studies of blood – 31. According to the studies, we found out, that there are certain breeds are more susceptible to babesiosis: mongrels, german shepherds, labrador retrievers and siberian huskies. Also found, that babesiosis more prone males than females. Dog babesiosis were usually diagnosed in young dogs, 1 to 2 years, but the hardest clinic gets puppies up to 1 year. The most frequent clinical manifestations in patients with babesiosis : apathy, anorexia, symptomatic anemia, change in body temperature, dark urine, vomiting, NS disorders, diarrhea, clinical jaundice. Morphological characteristics of the blood we found that in all cases, is characterized by thrombocytopenia, a decrease thrombocyte. The seasonal variation in the number of cases has been reported at all Veterinary clinics, with a higher incidence in the spring months (April, May) and peaking in autumn (September, November).
Rothman, Emma, and Jakob Erlandsson. "Potatisfibers inverkan på bröd : hur påverkas deg och bröd av potatisfiberns malningsgrad?" Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-19719.
Full textIntroduction: The potato fiber constitutes about 1 % of the weight of the potato and is a residual product in the manufacture of potato starch. Today, several well-known companies add potato fiber to their products. The main reason for this is because the fiber can bind liquid 7–12 times its own weight, which gives an economic advantage. Aim: The aim of this study is to investigate how the grind of potato fiber affects selected characteristics in dough and bread, with particularly focus on the storage stability of the bread. Method: Pilot tests Observations of dough characteristics Measure of water exchange and bread volume Instrumental color measurement with a colorimeter Sensory evaluation of storage stability Results: Pilot tests with both grinds of potato fiber showed that when comparing pre-treatments such as scalding, soaking and direct addition into the dough, a direct addition resulted with the most advantages, mainly regarding the softness of the dough. During the observations there was a visible difference in color between the potato fiber loaves and the reference loaf, which was not ensured in the instrumental color measurement. The volume and water retention in the bread was not affected by an addition of potato fiber. The sensory evaluation showed a perceived dryness for bread with added potato fiber (both grinds), when tested against a reference bread. The finely ground fiber affected the storage stability more than the coarse grounded fiber did. Conclusion: The grind gave no notable differences on the selected properties of dough and bread. The impact that grind had on dough characteristics and the finished bread were small.
Junqueira, Vinícius Silva. "Genomic information for breed determination, multibreed evaluation, and estimation of variance components in large populations." Universidade Federal de Viçosa, 2018. http://www.locus.ufv.br/handle/123456789/21565.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
A disponibilidade de uso de informações genômicas trouxe grandes oportunidades de aumento do ganho genético em sistemas produtivos de gado de corte. Apesar dos benefícios já conhecidos, implementação em larga escala nas condições nacionais ainda é um grande desafio principalmente pelo relativo alto custo de genotipagem. Uma alternativa economicamente viável é o desenvolvimento de painéis de marcadores SNP customizados para objetivos de melhoramento estrategicamente estabelecidos para características de interesse. A implementação dessa proposta tem maior impacto para os animais jovens. O objetivo desse estudo foi identificar o menor número necessário de marcadores do tipo SNP para diferenciar animais das raças Hereford, Nelore, Brahman e Braford genotipados com o painel 777K chip HD para bovinos. Adicionalmente, comparou-se o impacto na predição da proporção racial utilizando-se diferentes painéis reduzidos de marcadores do tipo SNP. Para isso, foram utilizados quatro diferentes métodos para a seleção de marcadores altamente informativos para a diferenciação racial. O software Admixture foi utilizado para os cálculos de proporção racial utilizando os painéis customizados. Os resultados observados nesse estudo sugerem a possibilidade de definir indivíduos às respectivas raças utilizando um painel de 24 marcadores do tipo SNP (isto é, 8 marcadores por raça pura). Informações de pedigree são por natureza incompletas e comumente não são bem definidas porque varias das ligações genéticas existentes não são conhecidas. A genômica trouxe grandes oportunidades para o cálculo do parentesco entre os indivíduos de uma população. Um dos principais desafios em implementações genômicas é a correta definição da população referência para o uso simultâneo das informações de pedigree e genômica. O conceito de metafundadores é baseado na definição de pseudo-indivíduos que descrevem os relacionamentos entre e dentre os indivíduos da população base. O objetivo desse estudo foi avaliar os impactos do uso de metafundadores ao estimar valores genéticos e sua habilidade preditiva utilizando a metodologia single- step GBLUP (ssGBLUP) em uma população multirracial. Três diferentes cenários foram adotados nesse estudo para a estimação de componentes de variância e predição dos valores genéticos: BLUP tradicional, ssGBLUP e ssGBLUP com inclusão de metafundadores. Um total de 28 metafundadroes foram definidos no modelo ssGBLUP+metafundadores. De forma geral, os modelos genômicos apresentaram maior habilidade preditiva. Sendo o modelo com inclusão de metafundadores o que apresentou maior habilidade preditiva. O método da máxima verossimilhança restrita (REML) é um método comumente utilizado para a estimação de componentes de variância. Por ser implementado em modelos mistos, apresenta estimativas corrigidas para efeitos de seleção. De forma geral, todos os animais genotipados são utilizados nos cálculos para a predição dos valores genéticos. O objetivo desse estudo foi avaliar quantas gerações são necessárias para acurada estimação de componentes de variância com o algoritmo para animais provados e jovens (APY) em uma população simulada com restrições de seleção. O uso de menor número de gerações reduziu a habilidade do modelo BLUP em estimar a herdabilidade simulada (0.30). A redução na estimação da herdabilidade pelos modelos genomicos são menores do que os modelos baseados em informações de pedigree. Os modelos genômicos apresentaram em média maior correlação que os modelo BLUP. Os resultados desse estudo sugerem que não é necessário grande número de gerações para acurada estimação dos componentes de variância e dos valores genéticos. O algoritmo APY não afeta a estimação dos componentes de variância. Duas gerações extras de animais não genotipados são suficientes para acurado cálculo dos componentes de variância, valores genéticos e também acurácia de predição dos valores genéticos.
The knowledge on breed composition is of major importance under design of breeding schemes. With this respect, the estimation of such parameters must be as accurately as possible. Currently, most of genetic evaluation programs has been predicting breed composition based on pedigree datasets; but, such estimations only accounts for the expected (allele frequency) contributions across ancestors After the development and establishment of single nucleotide polymorphism (SNP) genotyping platforms on the last decade, an interest in genetic diversity studies has arisen and especially the study of individuals’ origin. The objective of the present study was to evaluate the minimum required number of ancestry informative markers necessary to differentiate Hereford, Nelore, Brahman and Braford breeds genotyped with 777 K Illumina Bovine HD Bead Chip. In addition, we also compared the effects of different panels size on breed composition inference under different AIMs methods. To that, it was used the high-density Illumina Bovine HD BeadChip with more than 777 K SNPs to elucidate the structure of Hereford, Nelore, Brahman and Braford populations. Three different ancestry informative marker methods were used to distinguish such populations. Additionally, random marker selection was considered. Admixture software was used to infer breed composition using very low-density SNP panels assembled with AIMs. Our results suggest that is possible to assign individuals to populations with high confidence using less than 8 SNP markers selected per breed. Although millions of SNP markers have been identified, only few of them are needed to accurately infer ancestry in a cost-effective manner. Pedigree information is by nature incomplete and commonly not well established simply because many of the true genetic ties existent between individuals are not a priori known or they can be even wrong. Genomic era brought new opportunities when calculating relationships between individuals. The challenge under genomic approaches is the correct definition of genetic base by the use of pedigree and genomic data. Genetic base may change as more individuals are included and are inadequately defined if populations are genetically structured. Metafounder concept relies on the definition of pseudo-individuals that describes some level of within and/or across genetic relationship between base population. The purpose of this study was to evaluate metafounder theory to estimate breeding values and the predictive ability under a single-step approach for a multibreed population. Three different scenarios were adopted to estimate variance components and to compute breeding values: pedigree-based model, single- step GBLUP and single-step GBLUP with addition of metafounders. A total of 28 different metafounders were included in the ssGBLUP+metafounder model. In general, it was possible to note that genomic models were able to greater ability to predict the future performance. Among genomic models, the inclusion of metafounder information could increment even more the predictive ability under cross-validation approach. Restricted maximum likelihood (REML) is a popular method for parameter estimation. Because it uses the mixed model equations, it is resistant to selection bias and efficient implementations are currently available. When genomic information is available, two versions of REML may be applicable. When only genotyped animals have phenotypes, genomic REML can be applied with a genomic relationship matrix. When only a fraction of animals is genotyped, a single-step REML is applicable. In general, it is of interest to include many genotyped animals in parameter estimation and into evaluations, to account for genomic selection or pre- selection. The aim of this study was to investigate to what extent generations truncation affects estimates for a simulated population under selection.The use of less generations reduced the ability of pedigree-based model in estimating the benchmark heritability (0.30). The decrease in heritabilities based on genomic information was less than using only pedigree relationships. Genomic models provided greater correlations than pedigree-based model; on average 25 points. Single-step genomic models do not require a deeper pedigree relationship to estimate reliable variance components and breeding values. The use of APY algorithm does not affect the estimation of variance components. An extra of 2 ungenotyped generations are sufficient to compute reliable variance components; as well as breeding values and accuracies.
Egenvall, Agneta. "Canine health, disease and death : data from a Swedish animal insurance database /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5433-6.pdf.
Full textTöllborn, Josefin. "Är olikheter i beteenden mellan hundraser urskiljbara redan i valpstadiet?" Thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-90021.
Full textFechner, Sophie Luisa. "Assessing dogs using a temperament test - will training affect the outcome? : a test-retest trial as a forensic tool." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/13120.
Full textTemperament Tests can be a forensic tool as they are often used to clarify legal cases in which dogs were allegedly involved in circumstances of aggression towards humans or other dogs. The test used in this study, the standardized temperament test of Lower Saxony, a battery type test of 36 situations scaled from 1-7 aims to identify those dogs that show disturbed or inadequate aggression at the point of the evaluation. To be able to use this test as a forensic decision making tool it is important to understand if aggressive behaviour shown in the test can be altered through training. The records of all Temperament Tests applied at the Hamburg Shelter since 2006 to 2016, a total of 264 were analysed. From these records, the dogs that were subject to two Temperament Tests were chosen: n= 28 dogs. These dogs had been subject to a first Temperament Test at the Shelter, were trained, and then took a re-test. The 36 situations comprising the test were bundled into 5 sub-groups of situations evaluating similar circumstances and the results of the first and the second temperament test were analysed applying a paired Wilcoxon signed rank test with continuity correction. The training the dogs had been subject to in the meantime was taken into consideration. The average values in two of the five bundles were lower in the second temperament test: in the bundle of situations where the dogs had to interact with threatening humans the average value went from 1.64 in the first test to 1.39 in the second test (P=0.03) and in the bundle of situations of dog-dog contact, the average value went from 1.98 in the first test to 1.53 in the second test (P=0.02). These results suggest that training does have an effect on the aggressive behaviour shown in some test situations. 23/28 dogs, 82,1%, passed the second Temperament Test after being trained at the shelter. Practical implications and future applicability of the test are discussed.
RESUMO - Testes de Temperamento podem ser uma ferramenta forense uma vez que são frequentemente utilizados para esclarecer casos legais nos quais cães alegadamente estiveram envolvidos em circunstâncias de agressão contra humanos ou outros cães. O teste utilizado neste estudo é o teste de temperamento estandardizado da Baixa Saxónia, na Alemanha. Este teste é constituído por uma bateria de subtestes, 36 situações avaliadas numa escala de 1-6 e pretende identificar aqueles cães que mostrem agressividade perturbada ou inadequada no momento da avaliação. Para poder utilizar este teste como ferramenta para tomar decisões forenses, é importante compreender se o comportamento agressivo mostrado no teste pode ser alterado através de treino. Foram analisados os resultados de todos os Testes de Temperamento aplicados no Abrigo de Hamburgo desde 2006 até 2016, um total de 264. Deste conjunto de dados foram selecionados todos aqueles cães que, por alguma razão, repetiram o Teste de Temperamento: n=28. Estes cães foram sujeitos a um primeiro Teste de Temperamento no abrigo, foram treinados e voltaram a ser testados. As 36 situações constituintes do teste foram agrupadas em cinco subgrupos de situações que avaliam circunstâncias similares e os resultados agregados do primeiro e segundo teste foram comparados utilizando um teste de Wilcoxon emparelhado e relacionados com o treino ministrado entretanto. O valor das médias de dois dos cinco subgrupos foram inferiores no segundo teste: no subgrupo de situações em que os cães tinham de interagir com humanos que agiam de forma ameaçadora o valor da média alterou-se de 1.64 no primeiro teste para 1.39 no segundo (P=0.03) e no subgrupo de interação cão-cão o valor médio alterou-se de 1.98 no primeiro teste para 1.53 no segundo (P=0.02). Estes resultados sugerem que o treino influencia o comportamento agressivo demonstrado em algumas situações do teste. Para além disso, 23/28 cães, 82,4%, passaram no segundo Teste de Temperamento. Foram discutidas implicações práticas e a aplicabilidade futura deste teste.
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Nødtvedt, Ane. "Epidemiology of canine atopic dermatitis /." Uppsala : Dept. of Clinical Sciences, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200747.pdf.
Full textDamsager, John. "Hundebid af mennesker : En analyse af behovet for et paradigmeskift i risikostyringen af hundebid." Thesis, Karlstads universitet, Institutionen för miljö- och livsvetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-56529.
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