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1

Barroso, Maria Cristina Tenreiro Pereira Rodrigues. "Detection of the MDR1 mutation in Portuguese dog breeds." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/19292.

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Dissertação de Mestrado Integrado em Medicina Veterinária
P-glycoprotein is an ATP-driven drug efflux carrier, encoded by the multidrug resistance gene MDR1, also been referred as ABCB1, that is responsible for the transport of a broad variety of compounds, including drugs commonly used in veterinary medicine, out of the cell against the concentration gradient. The influence of P-gp on drug disposition has been demonstrated in Collies and in other herding dog breeds since a severe intoxication in response to treatment with the antiparasitic drug ivermectin and other avermectins has been reported in a subpopulation of these breeds. This adverse reaction is related to a 4-bp deletion in the ABCB1 gene. To our knowledge, no study was conducted in portuguese dog breeds to detect this gene mutation and there is no available information for the clinicians about this fact and consequently, about the safety of the administration of drugs that are P-gp substrates. Thus, it is important to know the status about the presence of MDR1 in dog breeds in Portugal. The main objective of this project was to implement the genetic test to identify the gene mutation on MDR1 gene and to perform this analysis in several animals from dog breeds in Portugal to obtain their MDR1 genotype. For that, we performed biological samples of saliva in animals from the dog breeds belonging to Group 1 and from the ones already identified as affected. The diagnosis technique used was adapted from the ones utilized by other authors, namely Mealy and collaborators. We analyzed 105 animals, 21.9% of which are Barbado da Terceira, 9.5% are Cão da Serra d’Aires, 52.4% belonging to breeds known to carry the mutation and 16.2% to other breeds. With this study we were able to establish the analysis in our laboratory, we identified the mutation in dogs of breeds already signalized as having the mutation and we evidenced that the mutation already is in Barbado da Terceira - carriers.
RESUMO - DETEÇÃO DA MUTAÇÃO MDR1 NAS RAÇAS CANINAS PORTUGUESAS - A glicoproteína P é um transportador dependente de ATP, codificado pelo gene de resistência a fármacos MDR1, também conhecido como ABCB1, que é responsável pelo transporte contra o gradiente de concentração (para o espaço extracelular) de vários substratos, incluindo fármacos comummente utlizados em Medicina Veterinária. A influencia deste transportador na reação a fármacos foi demonstrada em Collies e outras raças pastoras devido ao desenvolvimento de sinais neurológicos, de intoxicação grave, após o tratamento destes animais com antiparasitários do grupo das avermectinas, nomeadamente, a ivermectina. Esta reação está relacionada com a deleção de 4 pares de base no gene canino ABCB1, descoberta em 2001, em cães com fenótipo sensível à ivermectina. Até à data, não temos conhecimento de nenhum estudo feito em Portugal para detetar esta mutação genética e não existe informação disponível para os clínicos sobre este facto e, consequentemente, sobre a segurança de administração de medicamentos que sejam substratos da gp-P. É, por isso, importante saber-se o estatuto MDR1 em raças caninas em Portugal. O principal objetivo deste trabalho foi implementar o teste genético para identificação da mutação genética no gene MDR1 e realizar esta análise em vários exemplares de raças caninas em Portugal para obter o seu genótipo MDR1. Para o efeito foram realizadas colheitas de amostras biológicas de saliva em exemplares das raças caninas pertencentes ao grupo I e das raças já identificadas como afetadas. A técnica de diagnóstico utilizada foi adaptada das técnicas utilizadas por outros autores, nomeadamente Mealey e colaboradores. Foram analisados 105 animais, 21.9% dos quais são Barbados da Terceira, 9.5% são Cão da Serra d’Aires, 52.4% pertence a raças já identificadas como portadoras da mutação e 16.2% a outras raças. Com a realização deste estudo, conseguimos estabelecer a técnica no nosso laboratório, identificámos a mutação em cães de raças já sinalizadas como tendo a mutação e detetámos evidências que a mutação também circula na raça Barbado da Terceira - portadores.
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2

Packer, Rowena M. A. "Quantitative investigation of healthy conformational limits in domestic dog breeds." Thesis, Royal Veterinary College (University of London), 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618296.

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There are increasing concerns that some pedigree breeding practices compromise canine welfare; with many breeds affected by inherited disorders likely due to adherence to breed standards that encourage exaggerated conformations. Consequently, calls for quantitative limits to be included in breed standards have been advocated to safeguard against conformations that are detrimental to canine welfare. This thesis explores the relationships between extreme conformation and disease-risk, to identify the most at-risk conformations currently being selected for, and recommend healthy 'limits'. Three conformation-related disorders of high welfare importance were investigated; brachycephalic obstructive airway syndrome (BOAS), intervertebral disc extrusion (IVDE) and corneal ulceration. Seven hundred dogs entering the RVe's small animal referral hospital were recruited over 14-months; their conformations quantified using established protocols and disease-status assessed. Generalised linear mixed-model analyses demonstrated for the first time that: (1) relatively shorter muzzles and relatively thicker necks increased the risk of BOAS; (2) relatively longer backs, miniaturisation and being overweight increased the risk of IVDE; and (3) the presence of nasal folds, relatively short muzzles, relatively larger eyelid openings and the presence of exposed sclera increased the risk of corneal ulcers. To test the risk estimates generated from this population, a second study of BOAS was carried out in a non-referral population. Short muzzles and thick necks were confirmed to be risk factors for BOAS, with two further lifestyle risk factors identified: obesity and neutering. A questionnaire-based study discovered an owner-perception of BOAS being 'normal for the breed' that may hamper efforts to reduce its prevalence in the future. As such, educational interventions to change attitudes may be required. The results of these studies are hoped to instigate and inform future breed standard revisions, and influence those within the breeding community to change current breeding practices to improve canine welfare by selecting for more moderate, lower-risk morphologies.
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Doyle, Don Richard Lau Tin-Man. "Canine design creating the modern dog park /." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Spring/master's/DOYLE_DON_7.pdf.

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4

Brodd, Louise. "Behavioural differences between and within retriever breeds." Thesis, Linköpings universitet, Biologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133200.

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The retriever breeds have the same origin and have long been used as a gundog for hunting of game, mostly birds. However, recently the retriever breeds have become a popular pet and show dog. This have affected the breeding of the dogs as the same traits are not bred for a gundog and a pet or show dog. Breeds as the Labrador retriever consists of a field- and common-type. The aim of this study is to investigate any differences between and within five of the retriever breeds in behaviours as retrieving, search and game reaction. 64 dogs undergoing the field trial Description of Function- Retriever was video recorded and scores from 430 dogs that have undergone field trials was obtained. Both differences between and within breeds were found when analysing both the videos and scores. In the video analysis, the Flatcoated retriever showed the most retrieving behaviours and was the most passive. The Nova scotia duck tolling retriever was in both the video and score analyses the most active breed. The Labrador retriever scored high in game reaction. The field- and mixed-types had almost always higher scores in behaviours linked to hunting, compared to the common-type. This supports findings that recent selection in breeding have a larger effect on behaviour than the origin uses of the dogs.
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Huitson, Niki Rae. "An exploratory analysis of the emergence and implications of Breed Specific Legislation: knee-jerk reaction or warranted response? /." Burnaby B.C. : Simon Fraser University, 2005. http://ir.lib.sfu.ca/handle/1892/2361.

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6

Alcaraz, Rodríguez Patricia [Verfasser]. "Molecular genetic analysis of haemophilia A and B in several dog breeds / Patricia Alcaraz Rodríguez." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1029606641/34.

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7

Knowler, S. P. "Characterisation of chiari-like malformation and secondary syringomyelia in selected toy dog breeds using magnetic resonance imaging." Thesis, University of Surrey, 2017. http://epubs.surrey.ac.uk/844721/.

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Chiari-like Malformation (CM) and secondary Syringomyelia (SM) is a complex, debilitating abnormality which compromises the normal cerebrospinal fluid movement of the central nervous system culminating in the development of fluid-containing cavities within the spinal cord and associated with behavioural signs of pain and neurological deficits. The prevalence of asymptomatic CM dogs suggest that cerebellar indentation and impaction may be normal anatomical variations and unsuitable as a definition of CM. Magnetic Resonance Imaging (MRI) remains the definitive means of diagnosing CM/SM and a morphometric technique of quantifying CM and SM on mid-sagittal MRI has been successfully applied and validated in previous studies to a cohort of Griffon Bruxellois (GB) dogs with and without CM and a mixed breed GB family crossed with a mesaticephalic breed (Australian Terrier). Using a refined technique which took account of recent research findings, morphometries using a triangulation of circles, lines and angles were used to ‘map’ MRIs of the whole brain and cervical region in order to quantify the severity of the CM and SM phenotype in the Cavalier King Charles (CKCS). A further morphometric analysis was undertaken to explore brachycephaly and miniaturization as risk factors for CM and SM by comparing their impact in the CKCS, Affenpinscher and Chihuahua breeds. The collective framework of lines and angles generated a unique ‘signature’ for the dog, characterised by “concertina” type flexures demonstrating the combined nature of segregated traits towards the severity in the phenotype. Compared to controls, CKCS with CM pain are characterised by increased brachycephaly and airorhynchy, while significant traits for SM in the three dog breeds included those reported for the GB, suggesting a common aetiology. The characterisation of the CM phenotype provides the possibility of a diagnostic tool for veterinarians and means to assist breeders with mate selection to reduce symptomatic prevalence of CM/SM.
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Moioli, M. "APPEARANCE OF OSSIFICATION CENTERS OF THE LIMBS AND SKELETAL DEVELOPMENT IN NEWBORN TOY-DOG BREEDS: RADIOGRAPHIC, MORPHOMETRIC AND HISTOLOGICAL ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/233994.

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The study aims to find out the chronological appearance of the ossification centers of appendicular skeleton of newborn toy-breed dogs during the first month of life and to correlate the data obtained with morphometric measures of the skeleton by radiological and anatomical approach. Data obtained were implemented with bone mineral density (BMD) analysis of the long bones and histological and histochemical analysis of limbs bone sections, to evaluate and quantify the trends of the ossification process and the architectural changes of ossification centers. The study was carried out in 37 newborn toy-breed dogs <28 days old, spontaneously died for unrelated reasons with this study, divided into 4 groups on the basis of age (first week, second week, third week and fourth week). The forelimbs and the hind limbs have been evaluated by radiological and histological analysis. Long bones, cranial and body measurements, both radiological and anatomical, were taken and the BMD of radius and ulna and of os femoris was calculated. The results have been correlated through statistical analysis and compared with standard charts proposed by Literature in order to assess significant differences with medium and large breed dogs. The appearance of most of the ossification centers reflects the timing of ossification of medium and large breed dogs, however the behavior of some ossification centers changes and therefore might be considered typical of toy-dog breeds. Femoral length could be taken into consideration as a parameter to assess the developmental rate and the age of toy-breed dogs during the growing period, particularly in the first 4 weeks of age. Increasing BMD is highly correlated with increasing long bones length and seems to confirm the space-time relationship between BMD in canine newborn skeleton and in long bones growth. The radiological, histological and bone mineral density analysis and the correlations between long-bones length, skull diameters, age and body mass, might be currently appropriate to determine the skeletal age in newborn toy-dog breeds.
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Serres, Armero Aitor 1992. "Understanding dog breed copy number differences in the framework of gray wolf copy number variation." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668662.

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L’estudi de la variació estructural complementa l’estudi de la variació de seqüència per revelar les complexitats de la variació fenotípica. Els gossos són l’espècie domesticada amb més variació fenotípica que existeix avui en dia, malgrat la seva baixa diversitat nucleotídica. Com a tal, estudiar sistemàticament la variació del nombre de còpies en un panell compost de més de 100 races de gossos, permet descobrir algunes de les bases d’aquesta diversitat fenotípica. En la recerca presentada en aquesta tesi, hem descrit un excés de variants estructurals en gossos si ho comparem amb el que s’esperaria segons la seva història genètica. Aquest fet podria explicar part de la seva variació morfomètrica, anatòmica i patològica. Per altra banda, l’estudi d’associació fenotípica que hem realitzat troba més de 90 variants de nombre de còpia associades a més de 10 fenotips, alguns dels quals desconeguts fins al moment. A més a més, hem trobat una correlació entre variants de nombre de còpia de baix efecte estadístic i altres variants genòmiques rellevants, com ara els patrons d’expressió d’ARN llargs no codificants o la presència de contactes de cromatina. El nostre estudi ha generat una gran quantitat d’hipòtesis que poden donar lloc a validacions funcionals posteriors.
The study of structural variation complements and synergizes with the study of sequence variation to unravel the intricacies of phenotypic variation. Dogs are the most phenotypically variable domesticated species existing today despite their remarkably low nucleotide diversity. As such, the systematized study of copy number variation in an extensive panel of over 100 dog breeds has the potential to unravel a fraction of the bases of phenotypic diversity which remain unexplored. This study finds an excess of structural variants in dogs compared to the expectation given their genetic history, which can potentially account for some of their morphometric, anatomical and pathological variance. Indeed, trait mapping finds over 90 copy number variants associated with more than 10 phenotypes, some of which were previously unknown or uncharacterized. Moreover, there is a correlation between low effect, associated copy number variants and other relevant genomic features such as the expression patterns of long non-coding RNA or the presence of long-range chromatin contacts. Our characterization of copy number variation in dogs has generated a wealth of hypotheses for further functional testing and validation.
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Comerford, Eithne Josephine. "Evaluation of extracellular matrix composition, metabolism, joint mechanics and joint conformation as potential predisposing factors of cranial cruciate ligament rupture in three dog breeds." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271882.

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Allaith, S. M. "Identifying of key proteoglycans in different anatomical regions of the canine cranial cruciate ligament from dog breeds at an altered risk to ligament disease and rupture." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3003228/.

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Cranial cruciate ligament disease and rupture (CCLD/ R) is a common orthopaedic condition in dogs. CCLD/ R can be due to trauma (least common) or to non-contact injury (most common). Once the cranial cruciate ligament (CCL) is damaged complications such as stifle osteoarthritis can occur. Different dog breeds are at an altered risk to CCLD/ R. Previous biochemical and ultrastructural studies have found that glycosaminoglycans (GAGs) were altered in high risk dog breeds when compared to CCLs from a dog breed at low risk of ligament rupture. We hypothesise that proteoglycans and GAGs may vary between different anatomical regions of the CCL, and between differentially predisposed dog breeds to CCLD/ R. Proteoglycans were determined by semi-quantitative Western blotting, quantitative RT-PCR (qRT-PCR), quantitative biochemistry, semi-objective histology scoring, and immunohistochemistry. Water and GAG content in the CCLs was also measured. Further qRT-PCR analysis was conducted to determine the expression of ECM proteases (ADAMTS -4 & -5) in the canine CCL. We showed with Western blot analysis that certain proteoglycans and GAGs were significantly different between anatomical regions of Staffordshire bull terrier CCLs. Data analysis between differentially predisposed dog breeds showed that the Staffordshire bull terrier CCLs (a moderate-high risk dog breed to CCLD/ R) had a significant increase in water content compared to greyhound CCLs (a low risk dog breed to CCLD/ R). Further, gene expression and Western blot analysis of fibromodulin, gene expression of aggrecan, and Western blot analysis of chondroitin-6 sulphate stubs were significantly increased in Staffordshire bull terrier CCLs compared to greyhounds. Decorin and ADAMTS-4 gene expression were significantly increased in greyhounds compared to Staffordshire bull terrier CCLs. Histology analysis showed that fibrocartilaginous regions were present in the CCL and were mainly observed in predisposed dog breeds to CCLD/ R. Furthermore, immunohistochemistry analysis showed that each proteoglycan had a different distribution throughout the CCL, which indicates that proteoglycans provide essential functionality to the CCL. The increase of certain proteoglycans and GAGs in CCLs of Staffordshire bull terriers might indicate increased fibrocartilage regions as a result of compressive loads. These changes in ECM content in the Staffordshire bull terrier indicate higher loading pressure on the CCL and could compromise the tissue, leading to increased incidence of disease and rupture. The increase of decorin in greyhounds could be essential for maintaining collagen fibril strength, whilst the increase of ADAMTS-4 could indicate a higher rate of turnover to regulate normal CCL homeostasis.
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Wagner, Franziska [Verfasser], Irina [Gutachter] Ruf, and Wolfgang [Gutachter] Oschmann. "Evolutionary transformations of the ethmoidal region in Canis lupus familiaris (Linné, 1758): effects of domestication on the turbinal skeleton in selected dog breeds / Franziska Wagner ; Gutachter: Irina Ruf, Wolfgang Oschmann." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2020. http://d-nb.info/1210555700/34.

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Grozelier, Anna. "Labrador and German shepherd breed differences in dog-human communication." Thesis, Linköpings universitet, Biologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119521.

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As our long-term companions, dogs’ communication with us is perhaps the most developed of all human- animal ones. This study was aimed to investigate breed differences of German Shepherds and Labradors in dog-human communication. This was obtained through two tests: a problem-solving task and a pointing test. These two tests target both directions of communication: how much dogs understand and respond to the pointing and how they communicate with humans when facing a problem. Additionally, hair cortisol was measured in the dogs and dog owners filled a behavioural questionnaire (C-BARQ). The main breed difference I found was that Labradors performed better in both tests. I also found that the latency of the dogs’ choices in the pointing test correlated with many factors, e.g. they chose quicker when: choosing correctly, when they had many physical contacts with the experimenter in the problem-solving task, when they were more intense, energetic dogs, when they had higher hair cortisol levels and when they had a confident body posture. This indicates that the latency of choice could depend on the confidence of the dog and on the trust in the experimenter as well as on energy level and focus ability. Overall, this study revealed a limited amount of breed differences, compared to a parallel study on Labrador types (hunting and show dogs), showing that intra-breed differences can be more important than inter-breed ones on a behavioural level.
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Bradshaw, Yolonda F. "The Impact of Breed Identification, Potential Adopter Perceptions and Demographics, and Dog Behavior on Shelter Dog Adoptability." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619162805127048.

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Doehring, Orlando. "Identification of breed contributions in crossbred dogs." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464461/.

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There has been a strong public interest recently in the interrogation of canine ancestries using direct-toconsumer (DTC) genetic ancestry inference tools. Our goal is to improve the accuracy of the associated computational tools, by developing superior algorithms for identifying the breed composition of mixedbreed dogs. Genetic test data has been provided by Mars Veterinary, using SNP markers. We approach this ancestry inference problem from two main directions. The first approach is optimized for datasets composed of a small number of ancestry informative markers (AIM). Firstly, we compute haplotype frequencies from purebred ancestral panels which characterize genetic variation within breeds and are utilized to predict breed compositions. Due to a large number of possible breed combinations in admixed dogs we approximately sample this search space with a Metropolis-Hastings algorithm. As proposal density we either uniformly sample new breeds for the lineage, or we bias the Markov Chain so that breeds in the lineage are more likely to be replaced by similar breeds. The second direction we explore is dominated by HMM approaches which view genotypes as realizations of latent variable sequences corresponding to breeds. In this approach an admixed canine sample is viewed as a linear combination of segments from dogs in the ancestral panel. Results were evaluated using two different performance measures. Firstly, we looked at a generalization of binary ROC-curves to multi-class classification problems. Secondly, to more accurately judge breed contribution approximations we computed the difference between expected and predicted breed contributions. Experimental results on a synthetic, admixed test dataset using AIMs showed that the MCMC approach successfully predicts breed proportions for a variety of lineage complexities. Furthermore, due to exploration in the MCMC algorithm true breed contributions are underestimated. The HMM approach performed less well which is presumably due to using less information of the dataset.
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van, Boom Kathryn. "Skeletal muscle composition in various breeds of domestic dogs: (A comparative study)." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31125.

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The rising rate of insulin resistance and type 2 diabetes in humans over the past two decades have been linked to increasing rates of obesity, aging and urbanisation. A similar pattern is occurring in domestic animals, specifically cats and dogs. Skeletal muscle is a vital organ in the regulation of blood glucose. Its composition in terms of muscle fibre type, metabolism and contractility can differ substantially between species, but is poorly studied in the domestic dog, in particular the various breeds. It was hypothesised that insulin resistance and type 2 diabetes may be associated with muscle fibre type, in particular, muscle with a low type I fibre content being a predisposing factor. Therefore, the aims of this study were to investigate the skeletal muscle fibre composition and metabolic profile in the Triceps brachii (TB) and Vastus lateralis (VL) of 16 breeds of domestic dogs (Canis lupus familiaris). A secondary aim was to correlate the skeletal muscle composition with breeds reported as having a high incidence of diabetes. Skeletal muscle samples were collected post mortem from the TB and VL of 38 dogs from different breeds, age and sex, and analysed for fibre type composition, fibre size, oxidative and glycolytic metabolic capacity (citrate synthase (CS), 3-hydroxyacetyl co A dehydrogenase (3-HAD), creatine kinase (CK) and lactate dehydrogenase (LDH) enzyme activities). There was no significant difference between the TB and VL in any of the measurements. Type IIA was the predominant fibre type for both muscle groups (TB: 43%; VL: 44%) followed by type I (TB: 33%; VL: 38%) and type IIX (TB: 24%; VL: 18%). The cross sectional area (CSA) of the fibres were all smaller compared to humans and other wild animals. Surprisingly, there was no difference in the CSA between the fibres types and muscle groups: Type I: TB: 1740 µm2 ; VL: 1712 µm2 , Type IIA: TB: 1690 µm2 ; VL: 1720 µm2 , Type IIX TB: 1726 µm2 ; VL: 1791 µm2 ). Metabolically, the muscle of the dog displayed a high oxidative capacity with high activities (all activities in µmol/min/g protein) for CS (TB: 61; VL: 49) and 3-HAD (TB: 53; VL: 46). Lower CK (TB: 6115; VL: 6279) and higher LDH (TB: 1550; VL: 1478) activities than humans indicated a lower and higher flux through the high energy phosphate and glycolytic pathway, respectively. These results indicate that the dog has a predominance of type IIA fibres along with a higher oxidative capacity. There appears to be no pattern in fibre type profile that could be associated with a predisposition of a specific breed to insulin resistance and diabetes, although many of the breeds with a known risk did not form part of the study sample. This is the first study to characterise the skeletal muscle composition of a large population of dogs (16 breeds), but the association of breed to diabetes was not found. Future studies should include younger and more animals, as well as a diabetic population of dogs.
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Kuhl, C. "An investigation of pedigree dog breeding and ownership in the UK : experiences and opinions of veterinary surgeons, pedigree dog breeders and dog owners." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/30548/.

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Pedigree dog welfare in the United Kingdom is a controversial subject. This PhD aimed to investigate small animal veterinary surgeons’ (VS), pedigree dog breeders’ (PDB) and owners’ perceptions surrounding canine health, their roles, information acquisition and the quality of online resources available to new dog owners. Via a mixed-methods approach VS and PDB were asked about their perceptions of pedigree dog welfare using online questionnaires. Focus groups were then used to explore these parties’ opinions on advising dog owners and buyers. Dog owners were administered an online questionnaire to explore drivers of dog acquisition and sourcing of information about canine health. A further sample of dog owners provided possible internet search terms they would use to find information on how to care for a new dog. These terms were used for a scoping review to examine the quality of available information. The VS and PDB exhibited varied perceptions relating to pedigree dog breeding, inherited disease and health screening programmes. Each group considered themselves the most knowledgeable on these topics and lacked clarity on how their roles interrelated. Focus groups showed conflicting views on advising dog owners and buyers. Dog owners varied in their drivers for ownership, from whom they obtained information and the internet search terms used when looking for information online. The scoping review identified a lot of easy to understand, poor quality information. VS and PDB need to better understand and appreciate each others’ roles, perspectives and knowledge to instigate effective collaboration and improve pedigree dog health. Owners are diverse and require a multifaceted educational approach to improve knowledge. The quality of online information for owners needs to be made clear and a coordinated approach involving all stakeholders is required to enable dissemination of practical, evidence-based information on pedigree dog health.
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Winnerhall, Louise. "The effect of breed selection on interpreting human directed cues in the domestic dog." Thesis, Linköpings universitet, Biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108847.

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During the course of time, artificial selection has given rise to a great diversity among today's dogs. Humans and dogs have evolved side by side and dogs have come to understand human body language relatively well. This study investigates whether selection pressure and domestication could reveal differences in dogs’ skill to interpret human directional cues, such as distal pointing. In this study, 46 pet dogs were tested from 27 breeds and 6 crossbreeds for performance in the two-way object choice task. Breeds that are selected to work with eye contact of humans were compared with breeds that are selected to work more independently. Dogs of different skull shape were also compared, as well as age, sex and previous training on similar tasks. No significant differences in performance were found between dogs of various age, sex or skull shape. There was a tendency for significant difference in performance if the dog had been previously trained on similar tasks. When dogs that made 100% one-sided choices were excluded, a tendency appeared for there to be a difference between the cooperative worker breeds compared to the other breeds for the time it took for dogs to make a choice. There is a correlation between the number of correct choices made and the latency for the dogs from being release to making a choice (choice latency). All groups of dogs, regardless of my categorization, performed above chance level, showing that dogs have a general ability to follow, and understand, human distal pointing.
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Wanner, Christine Helen. "'For the good of the breed' : care, ethics, and responsibility in pedigree dog breeding." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23431.

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This thesis examines how the ethics of caring for pedigree dogs differ in the contexts of dog showing and veterinary practice. By highlighting conflicts around the shared use of ‘ordinary language’, I show how tensions between show‐world and veterinary perspectives relate to divergent understandings of ‘health’. Canine bodies speak to vets and breeders in conceptually different ways, so much so that breed‐specific features can be considered ‘perfect’ in the show‐ring yet ‘pathological’ in the veterinary clinic. Developing the emergent anthropological perspective that care is both a moral and an embodied practice, I argue that the qualities of moral virtue and aesthetic virtu are inextricably linked in the care practices by which breeders aim to produce and sustain canine bodies in their idealised forms. Also fundamental to show‐world notions of care is the understanding that care for dog and care for breed are one and the same. In sharp contrast, veterinary practice attends to dogs as individuals rather than members of breeds. Here, I examine how breeders and vets respond to the multiple and conflicting demands of caring for pedigree dogs in the course of encounters often fraught with unresolved tension. Asking how seemingly irreconcilable notions of what counts as good health play out in these negotiations, I argue that care can depend on the ability to transcend – or at least overlook – different ethical orientations. In practice, I argue that negotiations between breeders and vets are often non‐verbal and based on a mutual understanding that the ability to work together in performing care relies not only on clear communication but, at times, on a knowing silence. Under ever‐increasing pressure to engage with veterinary notions of health, many show‐breeders now deem ignorance of veterinary knowledge – and silence in the face of disease – ethically virtuous. I therefore conclude that deliberate silence and selective ignorance enable breeders and vets to temporarily reconcile their different understandings of what is good, thus allowing both parties to meet their respective responsibilities of care.
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Bobic, Gavrilovic Bojana. "Reproductive patterns in the domestic dog : a retrospective study, with the Drever breed as model /." Uppsala : Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/10639782.pdf.

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Angleby, Helen. "Analysis of domestic dog mitochondrial DNA sequence variation for forensic investigations." Licentiate thesis, Stockholm, Kungl. tekniska högskolan (KTH), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299.

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Mazrier, Hamutal. "Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/12441.

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BREED RISK, IMMUNOPHENOTYPES AND GENOMIC STUDIES OF CANINE ATOPIC DERMATITIS Canine atopic dermatitis (AD) is a complex genetically-linked immunological hypersensitivity which has similar clinical signs and pathological features to human AD, and involves immune dysregulation and skin barrier impairment. This thesis examines genetic factors underpinning canine AD and focuses on breed prevalence and evaluation of changes in the blood. Sixteen breeds with increased relative risk (≥1.5) were identified and gender predisposition in two dog breeds was revealed. One clade of dog breeds is highly represented amongst AD patients worldwide, and with increased RR in Australia. A 19 cytokine/chemokine multiplex bio-assay measured significantly elevated CXCL8, IL-7 and IL-15 concentrations, and reduced Stem-cell factor (SCF) in plasma of canine AD patients (n=27) compared to controls (n=11). Microarray gene expression data from leukocytes of atopic dogs (n=6) and controls (n=6) revealed 603 differentially expressed (DE) genes. Amongst these, candidate immune-related genes were highlighted, including the most under-represented gene, IL-7 receptor alpha subunit (IL7R). Quantitative real time PCR confirmed reduced gene expression for genes of the IL-7/IL7R pathway. A significant enrichment cluster consisting of immune-related pathways was identified, including T-cell receptor and B-cell receptor pathways. Expression analysis of miRNA from leukocytes of AD dogs identified15 with differential patterns of expression. The miRNA cfa-miR-31 had low levels in atopic dogs, suggesting a potential immune impairment dysregulation. Integrating the data gathered in the array studies reported in this thesis together with the genetic structure of dog breeds provides a powerful model to enable better characterisation of Australian dog breed susceptibility to canine AD and breed-related phenotypes. The IL-7/IL7R pathway may play a key role in the immune response in canine AD, may provide biomarkers to assist with diagnoses, and is a potential target for therapeutic agents.
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Kristensen, Signe Frost. "Are mixed-breed dogs healthier than purebred dogs? A review of the current data on diseases and longevity in dogs." Thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-96779.

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In today’s world, more than 400 different dog breeds have been registered and the number continues to increase, as people come up with new ways of breeding dogs. Purebred dogs are prone to many inherited disorders, inbreeding depression and a decreasing gene pool. Mixed-breed dogs, on the other hand, are said to be less prone to these problems, as they have a higher genetic variation. This review combined knowledge from the last 25 years of research in the field of mixed-breed dogs and purebred dogs to see what we know and what we still need to examine further. The literature all in all agrees that mixed-breed dogs have an increased longevity, although other factors determine longevity other than breed. They also have a decreased risk of some of the major diseases such as organ disorders and cancer but are instead prone to other problems such as ruptured cranial cruciate ligament, behavioural problems such as aggression, accidents and diabetes. Future research needs to take the inverse relationship of body mass and longevity into account when measuring longevity between breeds and more studies should be made in the field of canine cancer, as this accounts for most deaths overall in dogs.
I dagens värld har mer än 400 olika hundraser registrerats och antalet fortsätter att öka gradvis, eftersom människor kommer med nya sätt att avla hundar. Renrasiga hundar kan ha stora problem med ett flertal ärftliga störningar, inavelsdepression och en minskande gen pool. Å andra sidan sägs hundar med blandad ras vara mindre benägna för dessa problem, eftersom de har en högre genetisk variation. Denna översyn sammanfattar kunskap från de senaste 25 årens forskning inom området blandade hundar och renrasiga hundar för att se vad vi vet och vad vi fortfarande behöver undersöka ytterligare. Litteraturen är överens om att hundar med blandad ras har en ökad livslängd, även om andra faktorer avgör livslängder än rasen. De har också en minskad risk för några av de huvudsakliga sjukdomarna som organ defekter och cancer, dock kan de ha andra problem såsom brustet kranialkorsband, beteendeproblem som aggression, olyckor och diabetes, vilket påverkar livslängden. Framtida forskning måste ta hänsyn till det omvända förhållandet mellan kroppsmassa och livslängd vid mätning av livslängd mellan raser. Fler studier bör göras inom området cancer hos hundar, eftersom detta står för de flesta dödsfall totalt sett hos hundar.
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Kopechek, Mary Elizabeth. "Variation in the Onset and Expression of Hazard Avoidance Behavior Across Three Breeds of Domestic dogs." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1268233077.

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Taylor, Robyn. "How does temperament and breed influence learned aversion training in domestic dogs." Thesis, Taylor, Robyn (2017) How does temperament and breed influence learned aversion training in domestic dogs. Honours thesis, Murdoch University, 2017. https://researchrepository.murdoch.edu.au/id/eprint/39794/.

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Accidental poisoning of domestic dogs is an unfortunate occurrence when using poison baits to control introduced pests such as feral cats, red foxes, and wild dogs. This study aimed to investigate how dog breed (i.e., toy, terrier, sporting, domestic working and working dogs) and temperament influence aversion methods. Using non-poisonous baits and a device which emits a small electrical correction, domestic dogs were trained to avoid commercially-available non-toxic FoxOff® baits. Fifty-six dogs were recruited through online media services (e.g., Facebook). Each dog underwent four sessions of ‘one-on-one’ learned aversion training, spread across 6 weeks where individual dogs were subjected to a small electrical correction after having touched a non-toxic bait that has been attached to the training device and earthing rod (this created an electrical charged bait). Each dog’s behaviour, temperament and level of trainability were monitored during each session, based on temperament and behavioural test guidelines and procedures. Dog breeds were categorised based on their level of trainability; easy (i.e., only one to two training sessions and one to two repetitions of electrified baits during those sessions were required), moderate (i.e., only two to three training sessions and two to three repetitions of electrified baits during those training sessions were required), and difficult (i.e., all four training sessions and three repetitions of electrified baits during those four training sessions were required). The results indicated that 50 dogs were successfully trained to avoid the bait and that temperament and breed significantly influenced their level of trainability. Moreover, specific temperaments of obedience, excitability, playfulness and boldness were significantly related to each of the dog breeds respectively. Terriers were classified as having a difficult level of trainability; sporting and domestic working dogs displayed a moderate level of trainability, and working and toy dogs presented with easy levels of trainability based on their behavioural responses during the four training sessions. Furthermore, the temperament traits boldness (negatively correlated with trainability), fearfulness and anxiousness (positively correlated with trainability) significantly influenced dog trainability. This study demonstrated that learned aversion training with domestic and working dogs of different breeds and temperaments has future potential in relation to the development and implementation of practices involving learned aversion training methods for dogs.
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Wickens, Stephen Michael. "Social relationships in the domestic dog (Canis familiaris) : the effect of learning and breed on behaviour within status relationships." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283381.

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Kornberg, Krogh Linda. "When translators go barking up the wrong tree : A study of metaphor translation strategies in a dog breed book." Thesis, Linnéuniversitetet, Institutionen för språk (SPR), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-75906.

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The translation of metaphors can cause problems for a translator since what is typical for a metaphor is that the intended meaning does not match its literal meaning, which can lead to misunderstandings. Apart from this, language differences and cultural differences can also cause problems. This essay deals with the translation of metaphors in a dog breed book from English to Swedish. The aim of the essay is to investigate which translation strategies that are used when translating metaphors and whether lexicalized and non-lexicalized source language metaphors require different translation strategies.  The source language metaphors were found by using the Metaphor Identification Procedure which in this study means determining the lexical units in the source text, deciding the meaning of each unit and then comparing with dictionaries to see whether the lexical unit has a more basic or contemporary meaning and if the meaning in this particular context can be understood based on the more basic or contemporary meaning. If so, the lexical unit was determined to be metaphorically used in this context. The source language metaphors were then classified according to whether they are lexicalized or non-lexicalized, based on Dickins (2005) classification. The study finds that the most common way of translating a source language metaphor is by paraphrasing it into a non-metaphorical expression followed by using the same or a similar target language metaphor. No clear indications of lexicalized and non-lexicalized metaphors requiring different translation strategies were found.
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Bernardino, Filipa de Faria Pedro Verfasser], and Andrea [Akademischer Betreuer] [Fischer. "Investigation of an inherited cerebellar malformation in the Eurasier breed dog / Filipa de Faria Pedro Bernardino. Betreuer: Andrea Fischer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1078851875/34.

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Björnerfeldt, Susanne. "Consequences of the Domestication of Man’s Best Friend, The Dog." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7799.

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The dog was the first animal to be domesticated and the process started at least 15 000 years ago. Today it is the most morphologically diverse mammal, with a huge variation in size and shape. Dogs have always been useful to humans in several ways, from being a food source, hunting companion, guard, social companion and lately also a model for scientific research. This thesis describes some of the changes that have occurred in the dog’s genome, both during the domestication process and later through breed creation. To give a more comprehensive view, three genetic systems were studied: maternally inherited mitochondrial DNA, paternally inherited Y chromosome and biparental autosomal chromosomes. I also sequenced complete mitochondrial genomes to view the effect new living conditions might have had on dogs’ genes after domestication. Finally, knowledge of the genetic structure in purebred dogs was used to test analytic methods usable in other species or in natural populations where little information is available. The domestication process appears to have caused a relaxation of the selective constraint in the mitochondrial genome, leading to a faster rate of accumulation of nonsynonymous changes in the mitochondrial genes. Later, the process of breed creation resulted in genetically separated breed groups. Breeds are a result from an unequal contribution of males and females with only a few popular sires contributing and a larger amount of dams. However, modern breeder preferences might lead to disruptive selective forces within breeds, which can result in additional fragmentation of breeds. The increase in linkage disequilibrium that this represents increases the value of purebred dogs as model organisms for the identification and mapping of diseases and traits. Purebred dogs’ potential for these kinds of studies will probably increase the more we know about the dog’s genome.
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30

Seefried, Franz Reinhold. "Genomic characterisation and polymorphism analysis of candidate genes for milk production traits and association studies in three cattle breeds." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/668346/668346.pdf.

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Candela, Andrade Mario [Verfasser]. "Patellar luxation and concomitant cranial cruciate ligament rupture in small breed dogs / Mario Candela Andrade." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/121092563X/34.

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32

Barjaktarevic, Cécile. "L'évaluation des actifs incorporels : le cas des marques et brevets." Paris 9, 1987. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=1987PA090071.

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Les marques et brevets sont des actifs particuliers dont l'importance économique est considérable pour une entreprise. On s'étonnera, des lors, du faible intérêt qu'y portent les firmes françaises, notamment en ce qui concerne les brevets. En tant qu'actifs, ces éléments ont une valeur qu'il convient de déterminer dans le seul cas d'un transfert de propriété, dans la mesure où la comptabilité ne reconnait leur existence que s'ils ont été acquis par l'entreprise et non créés par elle. La plupart des méthodes d'évaluation ainsi rencontrées, sont fondées sur les couts et non sur les revenus dégagés de l'exploitation des marques et brevets concernes. Seule la méthode des redevances a une approche par les rendements, et est donc justifiée d'un point de vue économique. Cependant, elle est assez peu utilisée par les praticiens, on ne peut que se demander pourquoi. Cette étude démontre, sur la base d'un échantillon de contrats de licence de marques et de brevets, l'influence prépondérante du niveau de résultat sur le niveau de redevances, et donc sur la valeur de l'actif, qui s'apprécie, comme tout autre immobilisation, à partir des rendements prévisionnels
Trade-marks and patents are particular assets which economic importance is considerable for a firm. Therefore, we can be astonished by the little interest the french firms take in them, and especually in patents. As assets, these elements have a value we need to determine, only in the case of an assignment, providing that accounting admits their existence only if they have been bought by the firm, but not created by it. Most of the valuation methods refer to the costs and not to the trade-marks' and patents'exploitation earnings. The royalty method is the only one which has a yield approach, and therefore is justified economically wise. However, it is scarcely applied by experts. We may wonder why? Based on a sample of trade-marks' and patents' licence contracts. This research shows the pervasive influence that the results' level has on the royalties' level, and consequentely on the assets' value level, which, as any other asset, is valuated from actualised forecasted yields
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Jonikienė, Svetlana. "Mažųjų šunų veislės Lietuvoje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080317_132242-41115.

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Vis daugiau žmonių renkasi mažų veislių šunelius, kurie puikiai tinka ankštuose butuose. Mažų veislių šunelius įsigyja vieniši žmonės – kompanijai, kiti kaip žiurkgaudžius, kai kurie vietoj „skambučio“, bet daugiausia įsigyja kaip aksesuarą. Jorkšyro terjerai šiuo metu yra viena populiariausių šunų veislių Lietuvoje. Nuo 1992 metų iki 2007 metų lapkričio 11 dienos Lietuvos kinologų draugijos šunų veislių knygoje užregistruota: Jorkšyro terjerų veislės šunų 1045; Australijos šilkinių terjerų 10; Rusų žaisliukų užregistruota 343 (iš jų trumpaplaukių 175, o ilgaplaukių 168); Čihuahua 275 (iš jų trumpaplaukių 53, o ilgaplaukių 222). Įregistruotų veislynų skaičius iki 2007 metų lapkričio 11 dienos: Jorkšyro terjerų veislės 66; Australijos šilkinių terjerų 1; Rusų žaisliukų užregistruota 25 (iš jų trumpaplaukių 14, o ilgaplaukių 11); Čihuahua 22 (iš jų trumpaplaukių 5, o ilgaplaukių 17). Parenkant ir poruojant veislinius šunis labai svarbu jų giminingumas. Giminingas veisimas gali turėti tiek teigiamų, tiek ir neigiamų pasekmių populiacijai. Gali padidinti proporciją homozigotų, turinčių reikalingą požymį. Kaip neigiama pasekmė yra tai, kad padidėja paveldimų recesyvinių ligų - inbrydingas padidina homozigotiškumo, tuo pačiu ir ligos, tikimybę. Iš nagrinėtų Estijos dviejų Australijos šilkinių terjerų veislynų „Magik šou“ ir „Volitans“ Australijos šilkinių terjerų kilmės dokumentų giminingo poravimo atvejų nerasta. Išnagrinėjus trijų Lietuvoje esančių Jorkšyrų terjerų veislynų... [toliau žr. visą tekstą]
More and more people choose small dogs breeds, because these dogs perfectly suit for the small apartments. Lonely people choose small dog breeds as well – as a company, rat – catchers, instead of “door – bell“, or very often as an accessory. Yorkshire Terrier recently is one of the most popular dogs breeds in Lithuania. From 1992 till 11th of November, 2007 in the dogs breeds’ book in Lithuanian Cynological Society there were registered: 1045 Yorkshire Terriers,10 Australian Silky Terriers, 343 Russian Toy dogs (175 shorthaired and 168 longhaired ones), 275 Chihuahua (53 shorthaired and 222 longhaired ones). There was this number of breeding grounds registered till 11th of November, 2007: 66 of Yorkshire Terriers, 1 of Australian Silky Terriers, 25 of Russian Toy dogs (14 shorthaired and 11 longhaired), 22 of Chihuahua (5 shorthaired and 17 longhaired). Selecting and mating pedigree dogs it is very important to pay attention to their relationship. Mating relative dogs can have positive results to the population as well as negative ones. It can increase the proportion of homozygote having a required feature. A negative side is a possible increase of recessive diseases – inbreeding increase the possibility of homozygotism, and at the same time increase the possibility of diseases. In the investigated cases in two Estonian breeding grounds for Australian Silky Terriers, no relationship mating was found in the pedigree documents. Pedigree documents investigation was made in three... [to full text]
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34

da, Cunha Daise Nunes Queiroz. "Properties of flow through the ascending aorta in boxer dogs with mild aortic stenosis momentum, energy, Reynolds number, Womersley's, unsteadiness parameter, vortex shedding, and transfer function of oscillations from aorta to thoracic wall /." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1243910694.

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35

Fischer, Ida. "Does Lifestyle Affect the Attachment between Dogs, Canis familiaris, and Their Owner?" Thesis, Linköpings universitet, Biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148778.

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The aim of this study was to investigate if the dog’s behaviour and the interactions between the dog and the owner   differ depending on lifestyle, breed or sex of the dog. For this we employed the Strange Situation Procedure, a test inspired from Mary Ainsworth´s study,   which investigated the attachment of human infants to their mothers. There were two breeds, Border collie and Shetland sheepdog and a total of 58 dogs that participated in this study. The two breeds were divided into two lifestyles, competition dogs and pet dogs. A PCA was used to find correlations between the behavioural variables and the factors were then analysed in a Mann Whitney U test to test the differences between breed, sex and lifestyle. In this study no differences in behaviour between the two lifestyles were shown. However, the results showed that there were some differences between the two breeds and between the two sexes in behavioural expressions. The differences between the breeds were quite expected because there are many different breeds today which are selected for various morphology and behavioural traits which could influence their behaviour. The difference in behaviour between the two sexes can be because of evolutionary heredity. Further studies on this subject should have bigger and more even sample size, longer separation time, a more balanced gender distribution of the owners and to also analyze the cortisol levels.
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36

Martin, Vaquero Paula. "Cervical Spondylomyelopathy in the Great Dane Breed: Anatomic, Diagnostic Imaging, Functional, and Biochemical Characterization." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397420434.

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37

Hagman, Ragnvi. "New aspects of canine pyometra : studies on epidemiology and pathogenesis /." Uppsala : Dept. of Small Animal Clinical Sciences, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/v182.pdf.

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Koplitz, Shianne L. "Investigation and assessment of ejection murmurs and the left ventricular outflow tract in Boxer dogs." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1123596533.

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Starr, Alison Nicole. "Genomic analyses of induced hypercholesterolemia and atherosclerosis in a mixed breed colony of dogs and developmental abnormalities in the Havanese." Thesis, [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2516.

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40

Sundqvist, Anna-Karin. "Conservation Genetics of Wolves and their Relationship with Dogs." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8401.

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41

Scherenberg, Abello Alexandra. "La licence de droits de propriété intellectuelle, fondement d’une circulation organisée des biens." Paris 9, 2006. https://portail.bu.dauphine.fr/fileviewer/index.php?doc=2006PA090079.

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Le sujet conduit à s’interroger sur la légitimité des droits de propriété intellectuelle au regard du principe de circulation, définit comme le transfert potentiel d’objets dont un aspect au moins est protégé par un droit de propriété intellectuelle. La licence est un mode de transfert des biens, donc elle est un vecteur de circulation. Mais elle est plus que cela car ce qu’elle met en valeur est la disponibilité du bien et non son appropriation. Elle est ainsi le fondement d’une conception de la propriété intellectuelle fondée sur la circulation. En conséquence, la licence apparait comme un mécanisme de régulation permettant la circulation des biens. Les rapports de droit mis en place par le contrat de licence vont également dans le sens de cet objectif de circulation car la licence est à la fois le mode idoine d’exploitation du caractère multiple de la propriété intellectuelle et le moyen de satisfaire les intérêts multiples du concédant et du bénéficiaire de la licence
The subject leads to a wonder about the legitimity of intellectual property rights in comparison with the principle of circulation, defined as the potential transfer of objects, of which one aspect at least is protected by an intellectual property right. The licence is a mode of transfer of the goods; therefore it is a vector of circulation. But it is more than that, because what it emphasizes is the availability of the good and not it’s appropriation. It is thus the base of a conception of intellectual property rights based on circulation. Consequently, the licence appears as a mechanism of regulation allowing the circulation of the goods. The relationship created by the licence agreement contribute to this objective of circulation because the licence is not only the suitable mode of exploitation of intellectual property’s multiple character but also the means of satisfying the licensor and the licensee multiple interests
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42

Gaučas, Tadas. "PROBIOTIKŲ ĮTAKA SKIRTINGO DYDŽIO ŠUNIMS ĮVERTINANT MAISTO MEDŽIAGŲ PASISAVINAMUMĄ ORGANIZME BEI JŲ SVEIKATOS BŪKLĘ." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_142311-40533.

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„Naudingosios“ ar probiotinės bakterijos ypač išpopuliarėjo per paskutinius dešimtmečius. Kaip manoma, pirmasis mokslininkas pradėjęs tyrimus šioje srityje buvo rusų mokslininkas mikrobiologas E. Mečnikovas. XX a. pradžioje jis teigė, kad rauginto pieno produktai yra naudingi sveikatai dėl savo antagonistinio poveikio patogeninėms bakterijoms storajame žarnyne. Taip pat teigė, kad žmonių ir gyvūnų žarnyno mikroflora padeda kovoti su infekciniais agentais patenkančiais į virškinamąjį traktą. Darbo tikslas – nustatyti natūralaus probiotiko panaudojimo įtaką maisto medžiagų pasisavinimumui didelių, vidutinių ir mažų veislių šunų organizme ir įvertinti jų sveikatingumo būklę. Uždaviniams įgyvendinti buvo atlikti trys moksliniai bandymai, o jų eigoje atitinkamais laikotarpiais  virškinamumo bandymai. Tiriamosios grupės mažų veislių šunys per parą suvartojo 60,3 g sauso visaverčio ėdalo, arba 3,5 proc. mažiau (p<0,001), vidutinių veislių  200,3 g, arba 2,6 proc. mažiau, didelių veislių  530,3 g, arba 2,8 proc. mažiau palyginti su ėdalo suvartojamu kiekiu šunų kontrolinės grupės. Jogurto priedas turėjo įtakos drėgnio kiekiui išmatose: mažų veislių šunų išmatų sudėtyje nustatyta 35,2 proc., arba 1,6 proc. daugiau (p<0,001), vidutinių veislių  26,2 proc., arba 1,4 proc. daugiau (p<0,001), didelių veislių  24,2 proc., arba 1,6 proc. daugiau (p<0,001) sausosios medžiagos palyginti su šunų išmatų konsistencija, kurie natūralaus probiotiko negavo. Mažų veislių šunų organizme maisto... [toliau žr. visą tekstą]
“Beneficial” and probiotic bacteria became popular during the last decades. As it thought, the first scientist started these researches in this area was Russian scientist E. Mečnikov. At the beginning of the twentieth century, he stated that sour milk goods are very useful for health for their antagonistic effect to pathogenic bacteria in the large intestine. Also he stated that intestine micro flora of people and animals help to fight with infectious agents which get into the digestive tract. The aim of this study – to set influence of used natural probiotic for nutrient intake in organism of large, medium and small breed dogs, evaluating their state of health. Trying to implement tasks it was made three scientific tests and during them during appropriate periods – digestibility tests. Exploratory group – small breed dogs consumed 60.3 g dry full-rate food or 3.5 percent less (p<0.001) during the day; medium breed – 200.3 g or 2.6 percent; large breed – 530.3 g or 2.8 percent less compared with consumed amount of food of control dog group. Addition of yogurt had influence for humidity amount in excrements of dogs: in the composition of excrements of small breed dogs set 35.2 percent or 1.6 percent more (p<0.001); medium breed – 26.2 percent or 1.4 percent more (p<0.001); large breed – 24.2 percent or 1.6 percent more (p<0.001) dry matters compared with excrements of dogs, which did not get natural probiotic. In the organism of small breed dogs extra probiotic did not... [to full text]
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Kuraitė, Aura. "ŠUNŲ BABEZIOZĖS GENETINIAI ASPEKTAI." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_142456-38086.

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Tikslas: išanalizuoti įvairių veiksnių įtaką šunų babeziozės pasireiškimui, plitimui, atsižvelgiant į šuns lytį, amžių ir veislę, naudojant literatūros šaltinius bei asmeninius tyrimus. Duomenys buvo surinkti iš " Jakovo veterinarijos centras", smulkių gyvūnų klinikos "Pas Filą " ir kraujo tyrimai buvo renkami ir atliekami Veterinarijos ir diagnostikos centre. Iš viso surinkome 1195 ligos atvejų, atsižvelgiant į lytį, amžių bei veislę. Anamnezė buvo surinkta iš 117 šunų, kraujo mėginiai buvo imami iš 31 sergančio šuns, kraujo morfologiniams tyrimams. Išanalizavus esamus duomenis, pastebėjome, kad dažniausiai babezioze serga tam tikros šunų veislės: mišrūnai, vokiečių aviganiai, labradoro retriveriai ir sibiro haskiai. Atsižvelgiant į lytį, tai daugiausiai babezioze sirgo patinai ir žymiai rečiau patelės. Babezeliozė dažniausiai buvo diagnozuojama jauniems šunims, 1 iki 2 metų, bet sunkiausia klinika buvo pasireiškusi šuniukams iki 1 metų. Dažniausiai pasireiškianti klinikinė simptomatika: apatija, anoreksija, kliniškai išreikšta anemija, pakitusi kūno temperatūra, tamsus šlapimas, vėmimas, NS sutrikimai, viduriavimas, kliniškai išreikšta gelta. Analizuojant morfologinius kraujo rodiklių pokyčius, nustatėmė, kad visais atvejais buvo pasireiškusi trombocitopenija, sumažėjęs trombokrito kiekis. Pastebėjome, kad ligai būdingas sezoniškumas. Stipriausias babeziozės bumas pasireiškia pavasarį – balandžio, gegužės, birželio mėnesiais ir kiek silpnesnis – rudenį (rugsėjį, spalį). ... [toliau žr. visą tekstą]
Goal: to find out a variety of factors influence the occurrence of canine babesiosis, development, according to dog sex, age and breed, using known literature and personal research. The data were collected from „Jakovo veterinary center“, small animal clinic „pas Filą“ and the blood tests were collected and conducted at Veterinaty and Diagnostic center. We collected 1195 disease cases according to sex, age and breed. Anamnesis were collected from 117 dogs, morphological studies of blood – 31. According to the studies, we found out, that there are certain breeds are more susceptible to babesiosis: mongrels, german shepherds, labrador retrievers and siberian huskies. Also found, that babesiosis more prone males than females. Dog babesiosis were usually diagnosed in young dogs, 1 to 2 years, but the hardest clinic gets puppies up to 1 year. The most frequent clinical manifestations in patients with babesiosis : apathy, anorexia, symptomatic anemia, change in body temperature, dark urine, vomiting, NS disorders, diarrhea, clinical jaundice. Morphological characteristics of the blood we found that in all cases, is characterized by thrombocytopenia, a decrease thrombocyte. The seasonal variation in the number of cases has been reported at all Veterinary clinics, with a higher incidence in the spring months (April, May) and peaking in autumn (September, November).
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44

Rothman, Emma, and Jakob Erlandsson. "Potatisfibers inverkan på bröd : hur påverkas deg och bröd av potatisfiberns malningsgrad?" Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-19719.

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Introduktion: Potatisfibern utgör ca 1 % av potatisens vikt och är en restprodukt vid tillverkningen av potatisstärkelse. Idag tillsätter flera välkända livsmedelsföretag potatisfiber i sina produkter. Den främsta anledningen till detta är för att fibern kan binda vätska 7–12 gånger sin egen vikt vilket kan ge en ekonomisk fördel. Syfte: Syftet med studien är att jämföra hur grovmalen respektive finmalen potatisfiber påverkar utvalda egenskaper i degen och brödet med särskilt fokus på brödets lagringsstabilitet. Metod: Pilottester Observationer av degegenskaper Mätning av vätskeförlust och brödvolym Instrumentell färgmätning med en kolorimeter Sensorisk bedömning av lagringsstabilitet   Resultat: Pilottester av båda malningsgraderna av potatisfibern visade att vid en jämförelse av olika förbehandlingar så som skållning, blötläggning och tillsats direkt i degen, gav direkt tillsats av potatisfiber i degen flest fördelar, främst gällande mjukheten i degen. Vid observationen fanns en synlig färgskillnad mellan bröden med tillsatts potatisfiber och referensbrödet men detta säkerställdes inte vid den instrumentella färgmätningen. Brödens volym och vattenhållande förmåga påverkades inte av tillsats av potatisfiber. Den sensoriska bedömningen visade en upplevd torrhetskänsla för bröd med tillsatt potatisfiber (båda malningsgraderna) när det testades mot ett referensbröd. Den finmalda fibern påverkade lagringsstabiliteten mer än den grovmalda fibern gjorde.   Slutsats: Malningsgraden gav inga märkbara skillnader på de utvalda deg- och brödegenskaperna. Potatisfiber hade inte tillräckligt stor påverkan på deg eller bröd för att antas vara lönsam att tillsätta vid brödbakning.
Introduction: The potato fiber constitutes about 1 % of the weight of the potato and is a residual product in the manufacture of potato starch. Today, several well-known companies add potato fiber to their products. The main reason for this is because the fiber can bind liquid 7–12 times its own weight, which gives an economic advantage. Aim: The aim of this study is to investigate how the grind of potato fiber affects selected characteristics in dough and bread, with particularly focus on the storage stability of the bread. Method: Pilot tests Observations of dough characteristics Measure of water exchange and bread volume Instrumental color measurement with a colorimeter Sensory evaluation of storage stability   Results: Pilot tests with both grinds of potato fiber showed that when comparing pre-treatments such as scalding, soaking and direct addition into the dough, a direct addition resulted with the most advantages, mainly regarding the softness of the dough. During the observations there was a visible difference in color between the potato fiber loaves and the reference loaf, which was not ensured in the instrumental color measurement. The volume and water retention in the bread was not affected by an addition of potato fiber. The sensory evaluation showed a perceived dryness for bread with added potato fiber (both grinds), when tested against a reference bread. The finely ground fiber affected the storage stability more than the coarse grounded fiber did. Conclusion: The grind gave no notable differences on the selected properties of dough and bread. The impact that grind had on dough characteristics and the finished bread were small.
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45

Junqueira, Vinícius Silva. "Genomic information for breed determination, multibreed evaluation, and estimation of variance components in large populations." Universidade Federal de Viçosa, 2018. http://www.locus.ufv.br/handle/123456789/21565.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico
A disponibilidade de uso de informações genômicas trouxe grandes oportunidades de aumento do ganho genético em sistemas produtivos de gado de corte. Apesar dos benefícios já conhecidos, implementação em larga escala nas condições nacionais ainda é um grande desafio principalmente pelo relativo alto custo de genotipagem. Uma alternativa economicamente viável é o desenvolvimento de painéis de marcadores SNP customizados para objetivos de melhoramento estrategicamente estabelecidos para características de interesse. A implementação dessa proposta tem maior impacto para os animais jovens. O objetivo desse estudo foi identificar o menor número necessário de marcadores do tipo SNP para diferenciar animais das raças Hereford, Nelore, Brahman e Braford genotipados com o painel 777K chip HD para bovinos. Adicionalmente, comparou-se o impacto na predição da proporção racial utilizando-se diferentes painéis reduzidos de marcadores do tipo SNP. Para isso, foram utilizados quatro diferentes métodos para a seleção de marcadores altamente informativos para a diferenciação racial. O software Admixture foi utilizado para os cálculos de proporção racial utilizando os painéis customizados. Os resultados observados nesse estudo sugerem a possibilidade de definir indivíduos às respectivas raças utilizando um painel de 24 marcadores do tipo SNP (isto é, 8 marcadores por raça pura). Informações de pedigree são por natureza incompletas e comumente não são bem definidas porque varias das ligações genéticas existentes não são conhecidas. A genômica trouxe grandes oportunidades para o cálculo do parentesco entre os indivíduos de uma população. Um dos principais desafios em implementações genômicas é a correta definição da população referência para o uso simultâneo das informações de pedigree e genômica. O conceito de metafundadores é baseado na definição de pseudo-indivíduos que descrevem os relacionamentos entre e dentre os indivíduos da população base. O objetivo desse estudo foi avaliar os impactos do uso de metafundadores ao estimar valores genéticos e sua habilidade preditiva utilizando a metodologia single- step GBLUP (ssGBLUP) em uma população multirracial. Três diferentes cenários foram adotados nesse estudo para a estimação de componentes de variância e predição dos valores genéticos: BLUP tradicional, ssGBLUP e ssGBLUP com inclusão de metafundadores. Um total de 28 metafundadroes foram definidos no modelo ssGBLUP+metafundadores. De forma geral, os modelos genômicos apresentaram maior habilidade preditiva. Sendo o modelo com inclusão de metafundadores o que apresentou maior habilidade preditiva. O método da máxima verossimilhança restrita (REML) é um método comumente utilizado para a estimação de componentes de variância. Por ser implementado em modelos mistos, apresenta estimativas corrigidas para efeitos de seleção. De forma geral, todos os animais genotipados são utilizados nos cálculos para a predição dos valores genéticos. O objetivo desse estudo foi avaliar quantas gerações são necessárias para acurada estimação de componentes de variância com o algoritmo para animais provados e jovens (APY) em uma população simulada com restrições de seleção. O uso de menor número de gerações reduziu a habilidade do modelo BLUP em estimar a herdabilidade simulada (0.30). A redução na estimação da herdabilidade pelos modelos genomicos são menores do que os modelos baseados em informações de pedigree. Os modelos genômicos apresentaram em média maior correlação que os modelo BLUP. Os resultados desse estudo sugerem que não é necessário grande número de gerações para acurada estimação dos componentes de variância e dos valores genéticos. O algoritmo APY não afeta a estimação dos componentes de variância. Duas gerações extras de animais não genotipados são suficientes para acurado cálculo dos componentes de variância, valores genéticos e também acurácia de predição dos valores genéticos.
The knowledge on breed composition is of major importance under design of breeding schemes. With this respect, the estimation of such parameters must be as accurately as possible. Currently, most of genetic evaluation programs has been predicting breed composition based on pedigree datasets; but, such estimations only accounts for the expected (allele frequency) contributions across ancestors After the development and establishment of single nucleotide polymorphism (SNP) genotyping platforms on the last decade, an interest in genetic diversity studies has arisen and especially the study of individuals’ origin. The objective of the present study was to evaluate the minimum required number of ancestry informative markers necessary to differentiate Hereford, Nelore, Brahman and Braford breeds genotyped with 777 K Illumina Bovine HD Bead Chip. In addition, we also compared the effects of different panels size on breed composition inference under different AIMs methods. To that, it was used the high-density Illumina Bovine HD BeadChip with more than 777 K SNPs to elucidate the structure of Hereford, Nelore, Brahman and Braford populations. Three different ancestry informative marker methods were used to distinguish such populations. Additionally, random marker selection was considered. Admixture software was used to infer breed composition using very low-density SNP panels assembled with AIMs. Our results suggest that is possible to assign individuals to populations with high confidence using less than 8 SNP markers selected per breed. Although millions of SNP markers have been identified, only few of them are needed to accurately infer ancestry in a cost-effective manner. Pedigree information is by nature incomplete and commonly not well established simply because many of the true genetic ties existent between individuals are not a priori known or they can be even wrong. Genomic era brought new opportunities when calculating relationships between individuals. The challenge under genomic approaches is the correct definition of genetic base by the use of pedigree and genomic data. Genetic base may change as more individuals are included and are inadequately defined if populations are genetically structured. Metafounder concept relies on the definition of pseudo-individuals that describes some level of within and/or across genetic relationship between base population. The purpose of this study was to evaluate metafounder theory to estimate breeding values and the predictive ability under a single-step approach for a multibreed population. Three different scenarios were adopted to estimate variance components and to compute breeding values: pedigree-based model, single- step GBLUP and single-step GBLUP with addition of metafounders. A total of 28 different metafounders were included in the ssGBLUP+metafounder model. In general, it was possible to note that genomic models were able to greater ability to predict the future performance. Among genomic models, the inclusion of metafounder information could increment even more the predictive ability under cross-validation approach. Restricted maximum likelihood (REML) is a popular method for parameter estimation. Because it uses the mixed model equations, it is resistant to selection bias and efficient implementations are currently available. When genomic information is available, two versions of REML may be applicable. When only genotyped animals have phenotypes, genomic REML can be applied with a genomic relationship matrix. When only a fraction of animals is genotyped, a single-step REML is applicable. In general, it is of interest to include many genotyped animals in parameter estimation and into evaluations, to account for genomic selection or pre- selection. The aim of this study was to investigate to what extent generations truncation affects estimates for a simulated population under selection.The use of less generations reduced the ability of pedigree-based model in estimating the benchmark heritability (0.30). The decrease in heritabilities based on genomic information was less than using only pedigree relationships. Genomic models provided greater correlations than pedigree-based model; on average 25 points. Single-step genomic models do not require a deeper pedigree relationship to estimate reliable variance components and breeding values. The use of APY algorithm does not affect the estimation of variance components. An extra of 2 ungenotyped generations are sufficient to compute reliable variance components; as well as breeding values and accuracies.
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46

Egenvall, Agneta. "Canine health, disease and death : data from a Swedish animal insurance database /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5433-6.pdf.

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47

Töllborn, Josefin. "Är olikheter i beteenden mellan hundraser urskiljbara redan i valpstadiet?" Thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-90021.

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For about 14 000 years ago the domestication of the wolf, Canis lupus, began. This initiated the extensive work of breeding that resulted in man´s best friend, the dog. Its Latin name, Canis lupus familiaris, clearly shows how close they stand us people today. The Swedish Kennel Club has 343 registered breeds which are very different from each other in terms of the exterior, but also behaviourally. The behavioural differences in adult dogs of different breeds are commonly known. Something that is still in dispute is when these differences begin to manifest in the dog´s life. In this study two interview investigations were conducted with the aim to see whether distinct behavioural differences between breeds could be identified in the puppy stage. The breeds that were included in the study were American Staffordshire terrier, Border collie and Whippet. Two questionnaires were designed. One was sent to breeders because they were considered to have the most experience of the breeds in question. The other questionnaire was sent to veterinarians to get a more objective picture of the puppies’ behaviour. The results from the breeders showed that there was a statistically significant difference between the American Staffordshire terrier and Whippet puppies in their curiosity and the way they behaved socially. The outcome of the study is very interesting because it could mean that the breeding not only affects the behaviours of the adult dogs, but also the behavioural patterns of puppies. The results from the veterinarians showed that there was no difference between the breeds. The difference in results between the two groups could be due to the fact that different questions were asked, they have different preferences for the breeds, meet them in different environments, for different lengths of time or other sources of error. Further studies in this area are needed to investigate when the differences, which give dogs the title of the most varied species ethologically speaking, begin to appear.
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48

Fechner, Sophie Luisa. "Assessing dogs using a temperament test - will training affect the outcome? : a test-retest trial as a forensic tool." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/13120.

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Dissertação de Mestrado Integrado em Medicina Veterinária
Temperament Tests can be a forensic tool as they are often used to clarify legal cases in which dogs were allegedly involved in circumstances of aggression towards humans or other dogs. The test used in this study, the standardized temperament test of Lower Saxony, a battery type test of 36 situations scaled from 1-7 aims to identify those dogs that show disturbed or inadequate aggression at the point of the evaluation. To be able to use this test as a forensic decision making tool it is important to understand if aggressive behaviour shown in the test can be altered through training. The records of all Temperament Tests applied at the Hamburg Shelter since 2006 to 2016, a total of 264 were analysed. From these records, the dogs that were subject to two Temperament Tests were chosen: n= 28 dogs. These dogs had been subject to a first Temperament Test at the Shelter, were trained, and then took a re-test. The 36 situations comprising the test were bundled into 5 sub-groups of situations evaluating similar circumstances and the results of the first and the second temperament test were analysed applying a paired Wilcoxon signed rank test with continuity correction. The training the dogs had been subject to in the meantime was taken into consideration. The average values in two of the five bundles were lower in the second temperament test: in the bundle of situations where the dogs had to interact with threatening humans the average value went from 1.64 in the first test to 1.39 in the second test (P=0.03) and in the bundle of situations of dog-dog contact, the average value went from 1.98 in the first test to 1.53 in the second test (P=0.02). These results suggest that training does have an effect on the aggressive behaviour shown in some test situations. 23/28 dogs, 82,1%, passed the second Temperament Test after being trained at the shelter. Practical implications and future applicability of the test are discussed.
RESUMO - Testes de Temperamento podem ser uma ferramenta forense uma vez que são frequentemente utilizados para esclarecer casos legais nos quais cães alegadamente estiveram envolvidos em circunstâncias de agressão contra humanos ou outros cães. O teste utilizado neste estudo é o teste de temperamento estandardizado da Baixa Saxónia, na Alemanha. Este teste é constituído por uma bateria de subtestes, 36 situações avaliadas numa escala de 1-6 e pretende identificar aqueles cães que mostrem agressividade perturbada ou inadequada no momento da avaliação. Para poder utilizar este teste como ferramenta para tomar decisões forenses, é importante compreender se o comportamento agressivo mostrado no teste pode ser alterado através de treino. Foram analisados os resultados de todos os Testes de Temperamento aplicados no Abrigo de Hamburgo desde 2006 até 2016, um total de 264. Deste conjunto de dados foram selecionados todos aqueles cães que, por alguma razão, repetiram o Teste de Temperamento: n=28. Estes cães foram sujeitos a um primeiro Teste de Temperamento no abrigo, foram treinados e voltaram a ser testados. As 36 situações constituintes do teste foram agrupadas em cinco subgrupos de situações que avaliam circunstâncias similares e os resultados agregados do primeiro e segundo teste foram comparados utilizando um teste de Wilcoxon emparelhado e relacionados com o treino ministrado entretanto. O valor das médias de dois dos cinco subgrupos foram inferiores no segundo teste: no subgrupo de situações em que os cães tinham de interagir com humanos que agiam de forma ameaçadora o valor da média alterou-se de 1.64 no primeiro teste para 1.39 no segundo (P=0.03) e no subgrupo de interação cão-cão o valor médio alterou-se de 1.98 no primeiro teste para 1.53 no segundo (P=0.02). Estes resultados sugerem que o treino influencia o comportamento agressivo demonstrado em algumas situações do teste. Para além disso, 23/28 cães, 82,4%, passaram no segundo Teste de Temperamento. Foram discutidas implicações práticas e a aplicabilidade futura deste teste.
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49

Nødtvedt, Ane. "Epidemiology of canine atopic dermatitis /." Uppsala : Dept. of Clinical Sciences, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200747.pdf.

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50

Damsager, John. "Hundebid af mennesker : En analyse af behovet for et paradigmeskift i risikostyringen af hundebid." Thesis, Karlstads universitet, Institutionen för miljö- och livsvetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-56529.

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This Master thesis contains a risk assessment regarding the possibility for humans to be bitten by dogs in Denmark. As a part of this risk assessment the thesis contains an analysis of the effect of the introduction of legal bans of specific breeds in Denmark. Furthermore, the thesis contains an analysis of the societal context for the Danish legislation. This is done with back ground in models of risk management developed by James Reason and William Haddon Jr. The conclusion is that the Danish society continuously is vulnerable regarding the risk of humans being bitten by dogs – and that the ban of certain breeds have been without effect on the number of persons seeking hospital care for dog bites. The thesis demonstrates that the risk of human dog bites is highest in the private sphere and in the local area. The thesis reveal that the Danish state has failed to target the principal factors: context, situation and relation between man and dog in connection to situations where dog bites occur.

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