Journal articles on the topic 'Dogon Architecture'

In investigating the influence of religious thoughts on architecture, much attention has been given to divine world-wide religions by the researchers, while indigenous religions have to a great extent been neglected. Ancient tribes in different parts of the world, have, on the basis of their cosmology, shaped beliefs which reflect on their architecture, especially on their sacred buildings. Regarding the Dogons-a well-known and a dominant tribe in West Africa- their Gods, cosmology and beliefs have led to the formation of settlements comprising houses, temples and other types of buildings in accordance with their religious thoughts while also being in harmony with nature. Up on the expansion of Islam throughout Africa, especially West Africa, vernacular mosques are shaped gradually beside shrines making a typology of Islamic architecture which has traces of both Dogon and Islamic architecture within it; While the influence of natural materials and indigenous building techniques should not be neglected. Taking a descriptive-deductive analysis approach, this paper will search for the architectural creolization process and will eventually conclude that West African vernacular mosques inherit their formal and spatial features mostly from Dogon house and pioneer mosques in Medina and their physical features, elements and exterior decorations from Dogon temples.

The article examines the phenomenon of the penetration of elements of pre-Islamic decor into the architecture of mosques in the Dogon Country (Mali). In the case of Dogon architecture, one can observe a very peculiar version of the interaction of traditional culture with Islam. In itself, the use of forms and types of architectural structures traditional for the given territory is well known - it is enough to recall the Ottoman mosques. With the Dogon, the situation is different: the architecture of mosques reproduces not just the decor of a building directly related to traditional religion, but precisely those details of it that are associated with the worship of "idols", or fetishes. Similar incidents were recorded in other areas of Dogon modern traditional culture. A typical example is the prophet Amabir (Amabirɛ, “Creation of the Lord”, abbreviated as Abirɛ) Goro (Goro), who owns the prophecy that some day or other the Dogon will return to the Mande Country. The Dogon consider Amabire, and not Muhammad, the "last prophet" and connect the legend about him with the history of Islam in Mali. These cases indicate the penetration of pagan elements into Muslim architecture, as well as the penetration of Islam into pagan folklore and a clear desire to link them with each other. So this is evidence of the synthesis of Islam and traditional culture: pagan elements of Dogon heritage are no longer recognized as such, and Islamic elements are not identified by the Dogon only with religion.

To the field of professional architecture in Europe in the aftermath of World War II, the deserts of Western Africa were a margin that was viewed as an exterior to the modern metropolis and as a realm of escapism. However, to the ethnographic practices that had developed since the late 1800s, the notion of a desert hinterland supposed a primordial land, reflected in forms of habitation. For architects Herman Haan (1914–96) and Aldo van Eyck (1918–99), the desert was a tense geography that moved between being outside and at home. Revisiting the diaries from Haan and van Eyck’s journeys and their mediation of ethnographic methodologies alongside their engagement with modernist design, this article proposes that Haan’s impressions connect two seemingly opposite contexts: the Dogon lands on the Niger River, and Rotterdam. I argue that, in the architectural and ethnographic amateurism of Haan, the modernist metropolis and its exteriors were not delimited, distinct realms, but were rather engaged in a fluctuating relationship reflective of the contemporary fascination with post-Eurocentric landscapes in the discipline of architecture. I assert that this process of immersion was in fact a process of internalization of spatial experience.

Building Information Modelling (BIM) is a process for managing construction project information in such a way as to provide a basis for enhanced decision-making and for collaboration in a construction supply chain. One impediment to the uptake of BIM is the limited interoperability of different BIM systems. To overcome this problem, a set of Industry Foundation Classes (IFC) has been proposed as a standard for the construction industry. Building on IFC, the ifcOWL ontology was developed in order to facilitate representation of building data in a consistent fashion across the Web by using the Web Ontology Language (OWL). This study presents a critical analysis of the ifcOWL ontology and of the associated interoperability issues. It shows how these issues can be resolved by using Basic Formal Ontology (ISO/IEC 21838-2) as top-level architecture. A set of competency questions is used as the basis for comparison of the original ifcOWL with the enhanced ontology, and the latter is used to align with a second ontology – the ontology for building intelligent environments (DOGONT) – in order to demonstrate the added value derived from BFO by showing how querying the enhanced ifcOWL yields useful additional information.

Desde finales del siglo XIX algunos pintores, como el francés Paul Gauguin o el alemán Max Pechstein, habían sentido la necesidad de trasladarse físicamente a los lugares en que vivían pueblos primitivos, atraídos por la fuerza de su arte. No contentos con observar las producciones de estas culturas llamadas “primitivas” en los museos etnográficos, muchos artistas de las vanguardias europeas del siglo XX se lanzaron a un conocimiento directo de estas, emprendiendo largos viajes para compartir incluso su modo de vida. El primitivismo fue un ingrediente esencial en la formación de nuevo arte de vanguardia y en su defensa se pronunció de una manera inequívoca una figura tan relevante en la historiografía del arte como Wilhelm Worringer en 1911. En los años cuarenta, el escultor Jorge Oteiza viajó a los Andes colombianos en busca de una estatuaria original, el antropólogo Claude Lévi-Strauss publicó sus obras más importantes sobre las estructuras sociales de las culturas primitivas en los años sesenta y por esos mismos años el arquitecto Aldo van Eyck viajó y posteriormente escribió sobre el pueblo dogón. Todos estos autores se refieren a los mitos desarrollados en estas culturas, que se relacionan directamente con la tierra y con un eventual abatimiento del cielo sobre la tierra. Este escrito trata algunos de los modos en que se concreta esta relación entre lo que flota allá arriba y lo que sucede sobre la superficie del terreno, una relación de enorme importancia para la arquitectura y el arte de nuestro tiempo.

ABSTRACT Proper modulation of promoter chromatin architecture is crucial for gene regulation in order to precisely and efficiently orchestrate various cellular activities. Previous studies have identified the stimulatory effect of the histone-modifying complex NuA4 on the incorporation of the histone variant H2A.Z (Htz1) at the PHO5 promoter (A. Auger, L. Galarneau, M. Altaf, A. Nourani, Y. Doyon, R. T. Utley, D. Cronier, S. Allard, and J. Côté, Mol Cell Biol 28:2257–2270, 2008, http://dx.doi.org/10.1128/MCB.01755-07 ). In vitro studies with a reconstituted system also indicated an intriguing cross talk between NuA4 and the H2A.Z-loading complex, SWR-C (M. Altaf, A. Auger, J. Monnet-Saksouk, J. Brodeur, S. Piquet, M. Cramet, N. Bouchard, N. Lacoste, R. T. Utley, L. Gaudreau, J. Côté, J Biol Chem 285:15966–15977, 2010, http://dx.doi.org/10.1074/jbc.M110.117069 ). In this work, we investigated the role of the NuA4 scaffold subunit Eaf1 in global gene expression and genome-wide incorporation of Htz1. We found that loss of Eaf1 affects Htz1 levels mostly at the promoters that are normally highly enriched in the histone variant. Analysis of eaf1 mutant cells by expression array unveiled a relationship between NuA4 and the gene network implicated in the purine biosynthesis pathway, as EAF1 deletion cripples induction of several ADE genes. NuA4 directly interacts with Bas1 activation domain, a key transcription factor of adenine genes. Chromatin immunoprecipitation (ChIP) experiments demonstrate that nucleosomes on the inactive ADE17 promoter are acetylated already by NuA4 and enriched in Htz1. Upon derepression, these poised nucleosomes respond rapidly to activate ADE gene expression in a mechanism likely reminiscent of the PHO5 promoter, leading to nucleosome disassembly. These detailed molecular events depict a specific case of cross talk between NuA4-dependent acetylation and incorporation of histone variant Htz1, presetting the chromatin structure over ADE promoters for subsequent chromatin remodeling and activated transcription.

Abstract Tissue homeostasis depends on responses to environmental insults to restore cellular phenotype, microenvironment composition, and tissue architecture. Inflammation is essential to the disruption of homeostasis, and, in the pancreas, can destabilize the identity of terminally differentiated acinar cells. Herein we employ lineage-traced mouse models to delineate the chromatin dynamics that accompany the cycle of metaplasia and regeneration following pancreatitis, and unveil the presence of an epigenetic memory of inflammation in the pancreatic acinar cell compartment. We observe that despite histologic resolution of pancreatitis, acinar cells fail to return to their molecular baseline after several months, representing an incomplete cell fate decision. In vivo, this epigenetic memory controls lineage plasticity, with diminished metaplasia in response to a second inflammatory insult but increased tumorigenesis with an oncogenic Kras mutation. We demonstrate that both persistent chromatin and transcriptional changes constituting memory are recalled with oncogenic stress. Together, our findings define a capacity for an environmental insult to control future cell-fate decisions in a context-dependent manner. The ability of epigenetic memory to potentiate tumor initiation both broadens the relationship between inflammation and cancer and raises the possibility that inducing epigenetic ‘amnesia’ of an inflammatory insult could be leveraged as a novel cancer prevention strategy. Citation Format: David J. Falvo, Adrien Grimont, Paul Zumbo, Julie L. Yang, Alexa Osterhoudt, Grace Pan, Andre F. Rendeiro, John Erby Wilkinson, Friederike Dundar, Olivier Elemento, Rhonda K. Yantiss, Doron Betel, Richard Koche, Rohit Chandwani. An epigenetic memory of inflammation controls context-dependent lineage plasticity and KRAS-driven tumorigenesis in the pancreas. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Epigenomics; 2022 Oct 6-8; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2022;82(23 Suppl_2):Abstract nr PR008.

The Baroque style of architectural building, which had prevailed in much of Europe during the seventeenth and eighteenth centuries, emerged for the first time in the mid-eighteenth century in Istanbul. It was the Nuruosmaniye mosque in its Baroque tendencies that broke away from the traditional Anatolian and distinctive classical Sinan style of building. As Cerasi puts it, "It is no rough quotation or mere imitation of foreign styles, but a clever transposition of a foreign vocabulary into a perfectly dominated indigenous poesis." (Cerasi 1988: 98) This genius in reversing the roles and borrowing this foreign language of Baroque and applying it on a monument from Ottoman Turkey in a synthesis of two worlds is at the core of the Nuruosmaniye, which is considered one of the best representations of Baroque spirit in the Ottoman Empire. Moreover, what adds to this mystery is the little information regarding the architect and the direct origins that influenced the building of this mosque. This paper addresses the events that led to the building of the Nuruosmaniye and the penetration of Baroque influence into Turkey. While the character of the Nuruosmaniye retains a certain originality amongst the mosques of its time, true recognition of the Nuruosmaniye seems to have been suspended. With the exception of a few historians, the likes of Dogan Kuban and Aptullah Kuran, one may postulate that the Nuruosmaniye has been poorly represented in current historiography on Ottoman art—especially in contrast with previous Ottoman monuments, namely those of the Sinan period. While presenting a rich and rare evaluation of the Nuruosmaniye, this paper attempts to counterbalance the Nuruosmaniye's absence from literature dealing with Ottoman an history.

ABSTRACT The Middle East Geologic Time Scale (ME GTS) seeks to document and age-calibrate Arabian Plate transgressive-regressive (T-R) depositional sequences using: (1) Geological Time Scale of the International Commission on Stratigraphy (GTS), and (2) Arabian Orbital Stratigraphy time scale (AROS). AROS is based on an orbital-forcing glacio-eustatic model that offers three orbital clocks to date T-R sequences: (1) Stratons @ ca. 405 Ky; (2) Dozons @ ca. 4.86 My (12 stratons); and Orbitons @ ca. 14.58 My (36 stratons, three dozons). The Earth today is in Orbiton 0, which started ca. 1.5 Ma (SB 0); the ages of lower boundaries of orbitons can be estimated with the formula SB n = n × 14.58 + 1.5 Ma. This scheme was used to calibrate the Arabian Plate’s Mid-Permian to Early Triassic Khuff sequences, which contain one of the largest gas-bearing carbonate reservoirs in the World. The Khuff and equivalent formations have been interpreted by several authors in terms of six long-period sequences in outcrop belts and subsurface sections (Khuff sequences KS6 to KS1 in ascending order). Their type sections are briefly reviewed with emphasis on their boundaries, higher-order architecture and stage assignments. The age calibration starts at the basal Khuff Sequence Boundary (Khuff SB, Sub-Khuff Unconformity) defined in a type section in Al Huqf outcrop in Oman. Above the Khuff SB (ca. 268.9 Ma) the type sections of the oldest Khuff sequences KS6 (ca. 268.9–264.0 Ma) and KS5 (ca. 264.0–259.1 Ma) are defined in Oman and interpreted to each consist of twelve subsequences (stratons) with the predicted architecture of two consecutive dozons. By biostratigraphy they span the Mid-Permian (Guadalupian Epoch), Wordian and Capitanian stages. Type-Sequence KS4 (ca. 259.1–254.2 Ma) is defined in Iran and corresponds to the Wuchiapingian Stage. The Iranian type-Khuff Sequence KS3 (ca. 254.2–249.4 Ma) contains nine subsequences (stratons) grouped between two major exposure surfaces. By correlation to the Changhsingian Stage and Permian/Triassic Boundary (PTrB) type section in South China, it is interpreted as a dozon with three missing stratons. Khuff Sequence KS2 (ca. 249.4–247.8 Ma) contains the PTrB with an orbital age of ca. 249.0 Ma, compared to 251.0 ± 0.4 in GTS and 249.0–253.0 Ma by radiometric dating in its type section. Khuff sequences KS2 and KS1 contain 13 subsequences (stratons) between ca. 249.4–244.1 Ma spanning latest Permian and Early Triassic. The boundary of the Khuff with the overlying Sudair Formation, Sudair Sequence Boundary, is defined in Borehole SHD-1 (Central Saudi Arabia) and calibrated at ca. 244.1 Ma falling near the age of the Early/Mid-Triassic Boundary in GTS. The enclosed Chart shows a work-in-progress correlation of the six Khuff sequences across the Arabian Plate.

Background B-cell maturation antigen (BCMA) is a transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily involved in the regulation of B cell proliferation and survival as well as maturation/differentiation into plasma cells. In multiple myeloma cells, overexpression of BCMA has been shown to activate mitogen activated protein kinase pathways (AKT, ERK1/2, and NF-κB) and upregulates anti-apoptotic proteins (MCL1, BCL2, BCL-xL) resulting in cellular proliferation. Immunotherapeutic strategies targeting BCMA are showing great promise in heavily pre-treated refractory multiple myeloma. Light Chain Amyloidosis (AL) is a multisystem disorder of clonal plasma cells that results in the production of an abnormal light chain which misfolds and deposits in the organs leading to disruption of tissue architecture, cellular stress, dysfunction and eventually, death. The smaller burden and lower proliferative potential of the offending clonal plasma cells in amyloidosis may potentially lend itself favorably to immunotherapeutic strategies targeting BCMA. Given the efficacy of this approach in MM, the evaluation of BCMA expression on the surface of amyloidogenic plasma cells is warranted. Methods All patients diagnosed with Light chain Amyloidosis at Memorial Sloan Kettering Cancer Center, NY between January 1, 2012, and December 31, 2018, who had unstained bone marrow samples were identified. These unstained BM biopsy samples were prospectively stained for BCMA expression using Immunohistochemistry (IHC). We utilized a clinical-grade assay (clone D6; catalog sc-390147; company Santa-Cruz; monoclonal antibody; dilution 1:400) in a CLIA compliant setting. We scored the biopsies for BCMA expression, intensity, and site of staining. We also obtained their demographic details, staging, and cytogenetic information for the patients with available samples. Results During the queried period, 28 unstained samples were available for testing from the time of disease diagnosis. The median age of the population was 63 years (range 41-73). 64% of patients were male and consistent with the literature; a majority of patients (75%) had lambda-typic clonal plasma cells. Cytogenetic abnormalities using fluorescence in situ hybridization (FISH) were reviewed, t(11;14) was seen in 36% patients, and chromosome 1q and del 13q were each seen in 32% of patients. No patient had t(4;14) or del 17p. The median clonal PC burden in BM at diagnosis was 10% (range2-80%) and 36% had > 10% plasma cells. In clonal PCs, the median BCMA expression was 80% (range 20-100%). Only one patient had a staining intensity under 50% (20%). Membranous staining was noted in 82% of patients and a Golgi pattern in 11%. The median staining intensity was 2 (range 1-3). Of the patients with baseline diagnostic samples available for testing, six patients had additional unstained bone marrow samples for staining at the time of relapse. The majority of patients (83%) who relapsed had >10% plasma cells with a higher median plasma cell burden of 35% (range 10-80). The median BCMA expression was 65% (range 50-80) with no patient having <50% expression. The staining pattern was membranous in 50%, Golgi in 17%, and Golgi-membranous in 33%. At the time of relapse, the median clonal PC burden was 13% (range 5-30). BCMA expression continued to be present at the time of relapse with a median 75% (range 50-100) with predominantly membranous staining (83%). The median staining intensity in both diagnostic and relapsed tissue within the six samples studied was 1. Conclusions Our study represents the first description of BCMA expression on the surface of amyloidogenic plasma cells to our knowledge. BCMA is uniformly expressed by pathologic PCs in AL amyloidosis both at the time of diagnosis and relapse. Given the efficacy of BCMA directed therapy in multiple myeloma, further investigation of these agents in light-chain amyloidosis are warranted and may provide an effective therapeutic strategy in this devastating disease. Figure Disclosures Dogan: Corvus Pharmaceuticals: Consultancy; Celgene: Consultancy; Seattle Genetics: Consultancy; Novartis: Consultancy; Takeda: Consultancy; Roche: Consultancy, Research Funding. Giralt:Takeda: Consultancy, Research Funding; Johnson & Johnson: Consultancy, Research Funding; Kite: Consultancy; Novartis: Consultancy; Actinium: Consultancy, Research Funding; Jazz Pharmaceuticals: Consultancy; Celgene: Consultancy, Research Funding; Amgen: Consultancy, Research Funding; Miltenyi: Research Funding; Spectrum Pharmaceuticals: Consultancy. Hassoun:Novartis: Consultancy; Janssen: Research Funding; Celgene: Research Funding. Landau:Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Research Funding; Prothena: Membership on an entity's Board of Directors or advisory committees; Caelum: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; Karyopharm: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees.

Abstract Introduction: Treatment combinations involving CD38 targeted monoclonal antibodies have significantly prolonged the median duration and depth of response in myeloma (MM), reflected in minimal residual disease-negativity (MRD-) rates of over 70% in newly diagnosed patients (Landgren et al. JAMA Onc 2021). Key to improving our understanding of treatment failures is the combined use of single cell analysis of the microenvironment with genome wide assessment of tumor genetics to decipher the mechanisms of disease resistance. Methods: We isolated malignant plasma cells from bone marrow (BM) samples using CD138+magnetic or flow (CD38, CD138, and CD45) sorting from 60 newly diagnosed MM patients treated with KRd with daratumumab (D-KRd n=46; NCT03290950) and without daratumumab combination therapy (KRd, n=14; NCT01402284). Fifty-five baseline samples underwent whole genome sequencing (WGS), median coverage of 80x using somatic DNA as a normal comparator. The BM cellular content of 22 patients (44 samples-5 failed) treated with D-KRd (10 MRD+ and 12 MRD-) underwent 5'single cell RNA-sequencing with an additional capture of the TCR and surface protein markers (CITEseq) to interrogate the single cell composition of the immune microenvironment at baseline (T1, n=20) and at the end of induction (T2, n=19). Paired (T1/T2) single-cell data were obtained in 17 patients and paired WGS and single cell data (T1) were available in 15 patients. MRD-, sustained MRD- (defined as two MRD- results, the first at the end of the induction (T2) and the subsequent at the first year of follow-up (T3)) and progression/loss of MRD- were used as clinical endpoints for this study. Results: After a median follow up of 29 months, 36 (54%) patients achieved MRD-; 34 (51%) had sustained MRD- &gt;1 year after completion of combination therapy. Overall, 10 (15%) patients had clinical progression and two conversions from MRD- to MRD+. A comprehensive catalogue of MM-genomic events associated with these three clinical endpoints was defined. Deletion (del) 13, biallelic loss CYLD, del XBP1, del 20q13.12 (CD40), and 8q gains were associated with MRD+ and failure to achieve sustained MRD-. Presence of del RPL5 and multiple chromothripsis events significantly correlated with early progression and loss of MRD-. Interestingly, structural variants (SV) involving IKFZ3 were seen in all three negative clinical endpoints (p&lt;0.05) and also associated with early progression in the CoMMpass data set (p=0.01, n=12). Trisomy 21 emerged as a favorable subset (11/13 sustained MRD- cases p=0.02) and was also seen in CoMMpass (p=0.003). Overall, these data highlight potential novel genomic drivers associated with resistance to D-KRd. We interrogated the BM microenvironment at baseline and correlated its composition with the tumor genomic architecture. Across 15 evaluable patients, del XBP1 were associated with fewer memory B-cells (p=0.03), naïve B-cell (p=0.01) and dendritic cells (p=0.03) compared to the wild type. Also, low dendritic cell at baseline cases were observed in patients with del 20q13.12 (CD40) (p=0.03). Interestingly, low level of plasmacytoid dendritic cells at baseline was associated with failure to achieve MRD- and sustained MRD-. Patients with 6p24 amplification showed a reduced number of CD8 effectors 1 and 2 (p&lt;0.05). Overall, these data suggest that distinct genomic lesions are associated with distinct immune-microenvironment composition. When comparing baseline (T1) and end of induction (T2), significant differences were seen between sustained MRD+ and MRD-. We identified significantly depleted NK, and naïve and memory B-cell after D-KRd MRD- patients had significantly more CD14+ monocytes both at T1 and T2 than their MRD+ counterparts (Fig. 1). Differential expression suggests that inflammatory response genes including IL1B are upregulated in the absence of sustained MRD- whereas genes implicated in IL2, IL6, and IFNα response as well as adipocyte differentiation are associated with sustained MRD response. Conclusion: We show, for the first time, evidence of complex interplay between MM tumor genetics and the microenvironment in the context of D-KRd treated patients. Our results highlight the importance of genomic-based mechanisms in the persistence of disease (IKZF3, XBP1) as well as heterogeneity in the composition of the BM microenvironment, with the monocytes pointing towards the importance of inflammation. Figure 1 Figure 1. Disclosures Maura: OncLive: Honoraria; Medscape: Consultancy, Honoraria. Hassoun: Celgene, Takeda, Janssen: Research Funding. Mailankody: Jansen Oncology: Research Funding; Allogene Therapeutics: Research Funding; Bristol Myers Squibb/Juno: Research Funding; Legend Biotech: Consultancy; Takeda Oncology: Research Funding; Fate Therapeutics: Research Funding; Physician Education Resource: Honoraria; Plexus Communications: Honoraria; Evicore: Consultancy. Hultcrantz: Intellisphere LLC: Consultancy; GlaxoSmithKline: Membership on an entity's Board of Directors or advisory committees, Research Funding; Curio Science LLC: Consultancy; Amgen: Research Funding; Daiichi Sankyo: Research Funding. Scordo: Omeros Corporation: Consultancy; i3 Health: Other: Speaker; Kite - A Gilead Company: Membership on an entity's Board of Directors or advisory committees; Angiocrine Bioscience: Consultancy, Research Funding; McKinsey & Company: Consultancy. Kazandjian: Arcellx: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees. Shah: Janssen Pharmaceutica: Research Funding; Amgen: Research Funding. Landau: Takeda, Janssen, Caelum Biosciences, Celgene, Pfizer, Genzyme: Membership on an entity's Board of Directors or advisory committees; Takeda: Research Funding; Genzyme: Honoraria. Giralt: SANOFI: Membership on an entity's Board of Directors or advisory committees; PFIZER: Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees; JAZZ: Membership on an entity's Board of Directors or advisory committees; JANSENN: Membership on an entity's Board of Directors or advisory committees; AMGEN: Membership on an entity's Board of Directors or advisory committees; Actinnum: Membership on an entity's Board of Directors or advisory committees; CELGENE: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees. Dogan: Physicians' Education Resource: Honoraria; Seattle Genetics: Consultancy; EUSA Pharma: Consultancy; Roche: Consultancy, Research Funding; Takeda: Consultancy, Research Funding; Peer View: Honoraria. Lesokhin: Behringer Ingelheim: Honoraria; pfizer: Consultancy, Research Funding; Janssen: Honoraria, Research Funding; Iteos: Consultancy; Genetech: Research Funding; bristol myers squibb: Research Funding; Trillium Therapeutics: Consultancy; Serametrix, Inc: Patents & Royalties. Davies: Janssen: Consultancy, Honoraria; BMS: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Roche: Consultancy, Honoraria. Korde: Amgen: Research Funding; Medimmune: Membership on an entity's Board of Directors or advisory committees. Morgan: BMS: Membership on an entity's Board of Directors or advisory committees; Jansen: Membership on an entity's Board of Directors or advisory committees; Karyopharm: Membership on an entity's Board of Directors or advisory committees; Oncopeptides: Membership on an entity's Board of Directors or advisory committees. Landgren: Janssen: Other: IDMC; Celgene: Research Funding; Amgen: Honoraria; Janssen: Research Funding; Janssen: Honoraria; Amgen: Research Funding; Takeda: Other: IDMC; GSK: Honoraria.

Situations in which conflicting constraints clash can potentially provide linguists with insights into the architecture of grammar. This paper deals with such a case. When predicative modifiers of morphologically rich languages head relative clauses, they are involved in two, sometimes conflicting, agreement relationships. Different languages adopt different strategies in order to resolve situations of conflicting constraints. This paper focuses on Standard Arabic and the hybrid agreement strategy which it employs. It argues that the HPSG theory of agreement, which distinguishes between morphosyntactic and semantic agreement, constitutes an appropriate framework for accounting for the phenomenon. In addition, it shows that contrary to claims made by Doron and Reintges (2005), a non-derivational framework such as HPSG is adequate for accounting for this non-trivial agreement pattern. Moreover, with a constructional approach, whereby constraints can target syntactic structures above the lexical level, better empirical coverage is achieved.