Dissertations / Theses on the topic 'Domain expert'
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Pierre, Mattias. "Combining assembles of domain expert markings." Thesis, Umeå University, Department of Computing Science, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34405.
Full textBreast cancer is diagnosed in more than 6300 Swedish women every year. Mammograms, which are X-ray images of breasts, are taken as part of a nationwide screening process and are analyzed for anomalies by radiologists. This analysis process could be made more efficient by using computer-aided image analysis to assist quality control of the mammograms. However, the development of such image analysis methods requires what is called a “ground truth”. The ground truth is used as a key in algorithm development and represents the true information in the depicted object. Mammograms are 2D projections of deformed 3D objects, and in these cases the ground truth is almost impossible to procure. Instead a surrogate ground truth is constructed. ALGSII, a novel method for ranking shapes within a given set, was recently developed for measuring the level of agreement among ensembles of markings produced by experts of glandular tissue in mammograms. It was hypothesized in this thesis that the ALGSII measure could be used to construct a surrogate truth based on the markings from domain experts.Markings from segmentations of glandular tissue, performed by 5 different field experts on 162 mammograms, comprised the working data for this thesis project. An algorithm was developed that, given a fixed set of markings, takes an initial shape and modifies it iteratively until it becomes the “optimal shape” - the shape with the highest level of agreement in the group of markings according to the ALGSII measure. The algorithm was optimized with egard to rate of accepted shape changes and computational complexity.The developed algorithm was successful in producing an optimal shape according to the definition of maximizing the ALGSII measure in 100% of the cases tested. The algorithm showed stability for the given data set, and its performance was significantly increased by the implemented optimizations.
Wouters, Laurent. "Multi-domain expert-user modeling infrastructure." Paris 6, 2013. http://www.theses.fr/2013PA066200.
Full textThis work has been realized in an industrial context at the European Aeronautics Defense and Space Company (EADS). EADS is researching new ways to assess the safety of the overall human-machine system, i. E. , the aircraft, pilots and operating procedures as a whole. These safety assessments are conducted throughout the design cycle of the product, from the preliminary design to the detailed design and up to the certification phase. EADS is trying to perform these thorough safety assessments much earlier in the development cycle, when only models are available, thus, phasing-in a model-driven approach of the problem. An issue is then how to enable the collaboration of experts from multiple domains (cockpit, procedures, and cognitive psychology) for them to build a common model artifact that can be leveraged in the safety assessment of the overallhuman-machine system. This work considers that experts in each domain must be provided a domain-specific modeling environment, giving them access to a common model artifact, but through a domain-specific notation. This thesis identifies and considers three issues in this regard. First, the domain-specific modeling languages need to be semantically aligned so that the common model artifact can be consistently expressed. Second, multiple domain-specific visual notations need to be produced for the same underlying common model artifact. Third, domain experts modeling activities need to be supported at best and thus the provided domain-specific notations need to be as close as possible to the existing practices in the domains. This thesis then proposes the xOWL Infrastructure as an integrated solution to the three issues
Chronister, Julie Anne. "A domain-independent framework for structuring knowledge in the OFMspert architecture." Thesis, Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/25752.
Full textNasir, M. L. "Combining domain expert knowledge with neural networks for predicting corporate bankruptcies." Thesis, De Montfort University, 2000. http://hdl.handle.net/2086/10715.
Full textGoswami, Madan Gopal. "An approach towards the development of an expert system for paediatric problem domain." Thesis, University of North Bengal, 1999. http://hdl.handle.net/123456789/1039.
Full textNasuti, Frank W. "Knowledge Acquisition using Multiple Domain Experts in the Design and Development of an Expert System for Disaster Recovery Planning." NSUWorks, 2000. http://nsuworks.nova.edu/gscis_etd/746.
Full textSánchez, David. "Domain ontology learning from the web an unsupervised, automatic and domain independent approach." Saarbrücken VDM Verlag Dr. Müller, 2007. http://d-nb.info/991459016/04.
Full textLyon, Bruce. "Teraphim : a domain-independent framework for constructing blackboard-based expert systems in Prolog /." Online version of thesis, 1987. http://hdl.handle.net/1850/8858.
Full textOkoli, Justin. "Expert knowledge elicitation in the firefighting domain and the implications for training novices." Thesis, Middlesex University, 2016. http://eprints.mdx.ac.uk/22940/.
Full textAlshayji, Sameera. "The development of a fuzzy expert system to help top decision makers in political and investment domains." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6977.
Full textPiat, Guilhem Xavier. "Incorporating expert knowledge in deep neural networks for domain adaptation in natural language processing." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASG087.
Full textCurrent state-of-the-art Language Models (LMs) are able to converse, summarize, translate, solve novel problems, reason, and use abstract concepts at a near-human level. However, to achieve such abilities, and in particular to acquire ``common sense'' and domain-specific knowledge, they require vast amounts of text, which are not available in all languages or domains. Additionally, their computational requirements are out of reach for most organizations, limiting their potential for specificity and their applicability in the context of sensitive data.Knowledge Graphs (KGs) are sources of structured knowledge which associate linguistic concepts through semantic relations. These graphs are sources of high quality knowledge which pre-exist in a variety of otherwise low-resource domains, and are denser in information than typical text. By allowing LMs to leverage these information structures, we could remove the burden of memorizing facts from LMs, reducing the amount of text and computation required to train them and allowing us to update their knowledge with little to no additional training by updating the KGs, therefore broadening their scope of applicability and making them more democratizable.Various approaches have succeeded in improving Transformer-based LMs using KGs. However, most of them unrealistically assume the problem of Entity Linking (EL), i.e. determining which KG concepts are present in the text, is solved upstream. This thesis covers the limitations of handling EL as an upstream task. It goes on to examine the possibility of learning EL jointly with language modeling, and finds that while this is a viable strategy, it does little to decrease the LM's reliance on in-domain text. Lastly, this thesis covers the strategy of using KGs to generate text in order to leverage LMs' linguistic abilities and finds that even naïve implementations of this approach can result in measurable improvements on in-domain language processing
Yoon, Changwoo. "Domain-specific knowledge-based informational retrieval model using knowledge reduction." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011560.
Full textRamiah, Sivanes Pari. "Exploring and supporting expert and novice reasoning in a complex and uncertain domain : resolving labour disputes." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590930.
Full textChueh, Henry C. "Integration of expert knowledge into computer-controlled databases in the medical domain : HEMAVID, a case study." Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/29202.
Full textIncludes bibliographical references (leaves [165]-[172]).
by Henry C. Chueh.
M.S.
Blazek, Rick. "Author-Statement Citation Analysis Applied as a Recommender System to Support Non-Domain-Expert Academic Research." NSUWorks, 2007. http://nsuworks.nova.edu/gscis_etd/416.
Full textZhao, Wang. "Domain knowledge transformation (DKT) for conceptual design of mechanical systems /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841351.
Full textFick, David. "A virtual machine framework for domain-specific languages." Diss., Pretoria : [S.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-10192007-163559/.
Full textCass, Kimberly Ann. "Assessing the usefulness of domain and methodological tutorials for novice users employing an expert system as an advice-giving tool." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184607.
Full textEseryel, Deniz. "Expert conceptualizations of the domain of instructional design an investigative study on the deep assessment methodology for complex problem-solving outcomes /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2006. http://proquest.umi.com/login?COPT=REJTPTU0NWQmSU5UPTAmVkVSPTI=&clientId=3739.
Full textBasole, Rahul C. "Modeling and Analysis of Complex Technology Adoption Decisions: An Investigation in the Domain of Mobile ICT." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-06162006-142751/.
Full textRouse, William, Committee Chair ; DeMillo, Richard, Committee Member ; Cross, Steve, Committee Member ; Cummins, Michael, Committee Member ; Vengazhiyil, Roshan, Committee Member.
Perez-Torrents, Joël. "Gérer la collaboration entre l’expert métier et l’Intelligence Artificielle : Deux études de cas dans le système de soins." Electronic Thesis or Diss., Institut polytechnique de Paris, 2024. https://theses.hal.science/tel-04780193.
Full textArtificial Intelligence (AI) leverages machine learning methods to automate the creation of complex statistical models. These AI tools can perform tasks with expert-level proficiency, yet the precise way results are generated often remains opaque, posing challenges for their integration into organizations. This thesis explores the collaboration between domain experts and AI tools within the healthcare system.In the healthcare system, human-AI collaboration is particularly critical due to the professional and moral responsibilities inherent in medical decisions and their inherent uncertainty. While AI tools promise to address the tensions in this system by offering increased personalization of care at lower costs, they also raise concerns, and their real-world adoption remains to be fully realized.Our empirical approach includes two case studies, illustrating these dynamics. RADO focuses on the use of an AI tool by radiologists for mammographic analysis, aiming to enhance their activities. KOVAK, examines how a medical research team uses AI tools to analyze patient cohort data.A first analytical framework observes how experts leverage their knowledge to incorporate AI results, thereby demonstrating an engaged collaboration. A second one identifies the dual nature of the AI tool use, between a way to optimize an activity or generate learning. A third one, based on Peirce’s work on pragmatic inquiry, considers the AI tool as a partner in the knowledge construction process.We propose our collaboration model, EMC2 (Expert Machine Collaborative Community). It integrates various modes of managing expert-AI collaboration, thus facilitating better integration of this collaboration within organizations.This thesis contributes to the literature on human-AI collaboration models by defining management modes derived from an empirical approach. It also contributes to the literature on AI tool usage by specifying interrogative practices and by applying the concept of pragmatic inquiry
Selcuk, Dogan Gonca Hulya. "Expert Finding In Domains With Unclear Topics." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614259/index.pdf.
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Bangabash, Subhasish, and Srimanta Panda. "Machine Learning - Managerial Perspective : A Study to define concepts and highlight challenges in a product-based IT Organization." Thesis, Blekinge Tekniska Högskola, Institutionen för industriell ekonomi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-18835.
Full textInchamnan, Wilawan. "A framework for analysing creative activity within puzzle-game play experiences." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/82214/1/Wilawan_Inchamnan_Thesis.pdf.
Full textShah, Darsh J. (Darsh Jaidip). "Multi-source domain adaptation with mixture of experts." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121741.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (pages 35-37).
We propose a mixture-of-experts approach for unsupervised domain adaptation from multiple sources. The key idea is to explicitly capture the relationship between a target example and different source domains. This relationship, expressed by a point-to-set metric, determines how to combine predictors trained on various domains. The metric is learned in an unsupervised fashion using meta-training. Experimental results on sentiment analysis and part-of-speech tagging demonstrate that our approach consistently outperforms multiple baselines and can robustly handle negative transfer.
by Darsh J. Shah.
S.M.
S.M. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
Jayatilleke, Gaya Buddhinath, and buddhinath@gmail com. "A Model Driven Component Agent Framework for Domain Experts." RMIT University. Computer Science and Information Technology, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080222.162529.
Full textAlmeida, Reinaldo de Figueirêdo. "Análise de domínio na aquisição de conhecimentos: ontologias para sistemas computacionais." Faculdade de Educação, 2017. http://repositorio.ufba.br/ri/handle/ri/22595.
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A partir do alinhamento entre as Semióticas desenvolvidas pelos filósofos e pensadores, Charles Sanders Peirce, Gilles Deleuze e Félix Guattari, e da atualização teórica para a atividade de Análise de Domínio, baseada nos pressupostos defendidos pelos pesquisadores da Royal School of Library and Information Science, da Dinamarca, com destaque para Birger Hjørland e Torkild Thellefsen, esta Tese disserta sobre os aspectos de cognição a serem observados para determinar o significado num universo do discurso referente a fatos de um domínio, com o objetivo de aumentar o grau de aproximação entre as realidades, dos fatos, entendida e significada. Deste modo, é feito um aprofundamento no processo de aquisição do conhecimento, com a crítica à abordagem atomista e estruturalista, na qual, termos e relações do universo de discurso são especificados a partir de uma relação direta entre signo e significado, de uma concepção onde a expressão supera o conteúdo, e a dimensão espaço prevalece sobre a dimensão tempo no processo de significância. O ambiente de estudo usado é aquele referente às ontologias computacionais, bases de conhecimentos apoiadas sobre redes semânticas e semióticas de frames, concentrado nas fases que vão do entendimento da realidade de um domínio até aquela onde a significância dos termos e relações é tratada a fim de se obter os seus respectivos significados. A pesquisa, na sua fase experimental, dentro do referencial proposto, analisou as etapas de desenvolvimento da ontologia EDXL-RESCUER, contrapondo as hipóteses tratadas na Tese e o processo de desenvolvimento da ontologia, tendo como resultados, uma abordagem crítica e uma fundamentação teórica correspondente, complementada por uma metodologia para Análise de Domínio capaz de atuar numa dimensão pós-estruturalista. O método de pesquisa aplicado é qualitativo, exploratório, envolvendo atualização do estado da arte para os conceitos apresentados, a partir da análise de um projeto de construção de ontologia.
ABSTRACT From the alignment between the Semiotics developed by the philosophers, Charles Sanders Peirce, Gilles Deleuze and Felix Guattari, and the theoretical update for the Domain Analysis activity, based on the assumptions defended by the researchers of the Royal School of Library and Information Science, from Denmark, notably Birger Hjørland and Torkild Thellefsen, this thesis discusses the aspects of cognition to be observed to determine the signified in a universe of discourse concerning at facts of a domain, with the aim of increasing the degree of approximation between the realities, of the facts, understood and signified. In this way, a deepening of the process of knowledge acquisition is made, with the criticism at the atomist and structuralist approach, in which terms and relations of the universe of discourse are specified from a direct relation between sign and signified, a conception where the expression exceeds the content, and the space dimension prevails over the time dimension in the process of significance. The study environment used is that referring to computational ontologies, knowledge bases supported on semantic networks and semiotic frames, focused on the phases that go from the understanding of the reality of a domain to that where the significance of terms and relations is treated in order to obtain their respective signified. The research, in its experimental phase, within the proposed reference, analyzed the stages of development of the EDXL-RESCUER ontology, opposing the hypotheses treated in the thesis and the process of development of the ontology, resulting in a critical approach and a corresponding theoretical foundation, complemented by a methodology for Domain Analysis capable of acting in a post-structuralist dimension. The applied research method is qualitative, exploratory, involving updating the state of the art to the presented concepts, from the analysis of an ontology construction project
Ramdass, Dennis L. "Designing Bayesian networks for highly expert-involved problem diagnosis domains." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/53169.
Full textIncludes bibliographical references (leaves 55-56).
Systems for diagnosing problems in highly complicated problem domains have been traditionally very difficult to design. Such problem diagnosis systems have often been restricted to the use of primarily rule-based methods for problem diagnosis in cases where machine learning for probabilistic methods has been made difficult by limited available training data. The probabilistic diagnostic methods that do not require a substantial amount of available training data usually require considerable expert involvement in design. This thesis proposes a model which balances the amount of expert involvement needed and the complexity of design in cases where training data for machine learning is limited. This model aims to use a variety of techniques and methods to translate, and augment, experts' quantitative knowledge of their problem diagnosis domain into quantitative parameters for a Bayesian network model which can be used to design effective and efficient problem diagnosis systems.
by Dennis L. Ramdass.
M.Eng.
Lelebina, Olga. "La gestion des experts en entreprise : dynamique des collectifs de professionnels et offre de parcours." Thesis, Paris, ENMP, 2014. http://www.theses.fr/2014ENMP0027/document.
Full textIn a business world characterized by increasing complexity of technologies associated with the globalization of markets, technical knowledge and innovation become crucial assets and primary condition for developing competitive advantage. These issues are often associated with a particular figure within organizations: that of the expert. Indeed, these people are usually considered as a source of technological excellence and innovative solutions. It becomes thus crucial, in order to retain these key people, to value their expertise and to propose adequate conditions for the development of their knowledge and their innovation potential. As a response to this challenge, the dual ladder model was developed and has been soon recognized as a primary solution for the management of experts in the technological and industrial companies. This model proposes an alternative career path (technical ladder) to that of traditional managerial path. However, this solution, while a reference model in the management of experts, has not often brought satisfaction neither for those in charge of its implementation, nor for targeted individuals. Inspired by this paradox of the dual ladder model and building on the results of a longitudinal intervention-research, this thesis proposes a new problematization of the issue of expert’ management in organisations. We argue that not only the recognition policies for current experts should be taken into consideration, but also the issues of anticipation of future needs in expertise as well as the creation of new expertise areas. This thesis thus proposes an analytical framework that incorporates three lines of action: recognition policies for experts, strategic renewal of expertise and creation of new expertise domains. Each line is supported by the associated management tool, which was tested and validated in our fieldwork
Melvin, David G. "An investigation of hybrid systems for reasoning in noisy domains." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296622.
Full textNassiet, Didier. "Contribution à la méthodologie de développement des systèmes experts : application au domaine du diagnostic technique." Valenciennes, 1987. https://ged.uphf.fr/nuxeo/site/esupversions/e69df552-6494-4941-97a3-31d5454a5860.
Full textSoon, Lisa. "Knowledge Renewal and Knowledge Creation in Export Trading." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367002.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith Business School
Griffith Business School
Full Text
Whitley, Edgar A. "Embedding expert systems in semi-formal domains : examining the boundaries of the knowledge base." Thesis, London School of Economics and Political Science (University of London), 1990. http://etheses.lse.ac.uk/1/.
Full textRABAJOIE, PIERRE. "Contribution a l'elaboration d'un systeme expert dans le domaine des desordres acido-basiques et hydro-electrolytiques." Rennes 1, 1994. http://www.theses.fr/1994REN1M048.
Full textLima, Helano Póvoas de. "Uma abordagem para construção de sistemas fuzzy baseados em regras integrando conhecimento de especialistas e extraído de dados." Universidade Federal de São Carlos, 2015. https://repositorio.ufscar.br/handle/ufscar/7224.
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Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Historically, since Mamdani proposed his model of fuzzy rule-based system, a lot has changed in the construction process of this type of models. For a long time, the research efforts were directed towards the automatic construction of accurate models starting from data, making fuzzy systems almost mere function approximators. Realizing that this approach escaped from the original concept of fuzzy theory, more recently, researchers attention focused on the automatic construction of more interpretable models. However, such models, although interpretable, might not make sense to the expert. This work proposes an interactive methodology for constructing fuzzy rule-based systems, which aims to integrate the knowledge extracted from experts and induced from data, hoping to contribute to the solution of the mentioned problem. The approach consists of six steps. Feature selection, fuzzy partitions definition, expert rule base definition, genetic learning of rule base, rule bases conciliation and genetic optimization of fuzzy partitions. The optimization and learning steps used multiobjective genetic algorithms with custom operators for each task. A software tool was implemented to support the application of the approach, offering graphical and command line interfaces and a software library. The efficiency of the approach was evaluated by a case study where a fuzzy rule-based system was constructed in order to offer support to the evaluation of reproductive fitness of Nelore bulls. The result was compared to fully manual and fully automatic construction methodologies, the accuracy was also compared to classical algorithms for classification.
Historicamente, desde que Mamdani propôs seu modelo de sistema fuzzy baseado em regras, muita coisa mudou no processo de construção deste tipo de modelo. Durante muito tempo, os esforços de pesquisa foram direcionados à construção automática de sistemas precisos partindo de dados, tornando os sistemas fuzzy quase que meros aproximadores de função. Percebendo que esta abordagem fugia do conceito original da teoria fuzzy, mais recentemente, as atenções dos pesquisadores foram voltadas para a construção automática de modelos mais interpretáveis. Entretanto, tais modelos, embora interpretáveis, podem ainda não fazer sentido para o especialista. Este trabalho propõe uma abordagem interativa para construção de sistemas fuzzy baseados em regras, que visa ser capaz de integrar o conhecimento extraído de especialistas e induzido de dados, esperando contribuir para a solução do problema mencionado. A abordagem é composta por seis etapas. Seleção de atributos, definição das partições fuzzy das variáveis, definição da base de regras do especialista, aprendizado genético da base de regras, conciliação da base de regras e otimização genética da base de dados. As etapas de aprendizado e otimização utilizaram algoritmos genéticos multiobjetivo com operadores customizados para cada tarefa. Uma ferramenta de software foi implementada para subsidiar a aplicação da abordagem, oferecendo interfaces gráfica e de linha de comando, bem como uma biblioteca de software. A eficiência da abordagem foi avaliada por meio de um estudo de caso, onde um sistema fuzzy baseado em regras foi construído visando oferecer suporte à avaliação da aptidão reprodutiva de touros Nelore. O resultado foi comparado às metodologias de construção inteiramente manual e inteiramente automática, bem como a acurácia foi comparada a de algoritmos clássicos para classificação.
Costa, Nilson Santos. "Modelagem e Construção de uma ferramenta de autoria para um Sistema Tutorial Inteligente." Universidade Federal do Maranhão, 2002. http://tedebc.ufma.br:8080/jspui/handle/tede/306.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
One of the difficullties when building an Intelligent Tutoring System (ITS) is the domain model definition. This must be the result of knowledge acquisition from an experts, usually a teacher. This thesis presents the definition, modelling and implementation of an authoring tool. This tool, named authoring, provides cognitive evaluations to organize a knowledge set within an intelligent tutoring system. Through this tool, the knowledge (domain) of an Expert will be available for Mathnet System. This happens due to the edition or creation of an Expert authoring into a specific domain (knowledge). By the measures, it is possible the automation of a good curricular choice to the next phase to be some proposed by the peer, simulating the teacher s experience, in order to minimize the learning process and provide the use of many pedagogical strategies. Thus, the modelling and implementation of the authoring tool acts as a mechanism of creation and test of knowledge (domain).
Uma das maiores dificuldades na construção de um Sistema Tutorial Inteligente (STI) é a construção do Modelo de Domínio. Este deve ser o resultado da aquisição de conhecimentos a partir dos especialistas, geralmente professores da área e de pedagogia. Este trabalho apresenta a definição, modelagem e implementação de uma ferramenta de autoria. Esta ferramenta, denominada de autoria, terá medidas cognitivas para ordenar um conjunto de conhecimento para um Sistema Tutor Inteligente (STI). Com esta ferramenta, será disponibilizado o conhecimento (domínio) de um especialista para o sistema Mathnet1. Isto ocorrerá mediante a edição ou criação de uma autoria do especialista em um domínio específico (conhecimento). Por meio destas medidas será possível a automação de uma boa escolha curricular para a próxima etapa a ser trabalhada com o aprendiz (aluno), simulando a experiência do professor, a fim de minimizar o tempo de aprendizado e possibilitar a utilização de diversas estratégias pedagógicas. Desta maneira, a modelagem e implementação da ferramenta de autoria servirão como mecanismo de criação e testes de conhecimento (domínio).
Herbert, Margaret E. "The perceived nature and function of planning by domain-related experts: Academic, business, lay, and teacher." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9867.
Full textMcKee, Courtney Holmes. "Characterization of the nuclear import and export signals of the E7 protein of human papillomavirus type 11." Thesis, Boston College, 2011. http://hdl.handle.net/2345/1957.
Full textThe E7 protein of low risk HPV11 has been shown to interact with multiple proteins, including pRb, in both the cytoplasm and the nucleus. High risk HPV16 E7 and low risk HPV11 E7 share a novel nuclear import pathway independent of karyopherins but dependent on the GTPase Ran (Angeline, et al., 2003; Knapp, et al., 2009; Piccioli, et al., 2010). We continued to analyze the nucleocytoplasmic transport of HPV11 E7 in vivo through transfection assays in HeLa cells with EGFP-HPV11 E7 wild type and mutant fusion constructs. We found that nuclear localization of HPV11 E7 is mediated by a nuclear localization signal located in the C-terminal domain which contains a unique zinc-binding domain. Mutations of cysteine residues that interfered with zinc-binding clearly disrupted the nuclear localization of the EGFP-11cE7 and EGFP-11E7 mutants. These data suggest that the integrity of the zinc-binding domain is essential for the nuclear localization of HPV11 E7. In addition, we discovered that HPV11 E7 has a leucine-rich C-terminal nuclear export signal (NES) (76IRQLQDLLL84) mediating the nuclear export of HPV11 E7 in a CRM1-dependent manner
Thesis (BS) — Boston College, 2011
Submitted to: Boston College. College of Arts and Sciences
Discipline: Biology Honors Program
Discipline: Biology
Larrechea, Michel. "Méthodologie de modélisation des connaissances dans le domaine du diagnostic technique." Bordeaux 1, 1995. http://www.theses.fr/1995BOR10651.
Full textBusque-Carrier, Mathieu. "Création d'un modèle de valeurs de travail avec items validés auprès d'experts du domaine de l'orientation." Mémoire, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6945.
Full textEmero, Michael F. "Using naturally occurring texts as a knowledge acquisition resource for knowledge base design : developing a knowledge base taxonomy on microprocessors /." Master's thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-02162010-020204/.
Full textBrena, Ramón Jacquet Paul Mossière Jacques Trilling Laurent Jorrand Philippe. "Synthèse de programmes connaissances et déduction dans les domaines d'application /." S.l. : Université Grenoble 1, 2008. http://tel.archives-ouvertes.fr/tel-00333349.
Full textBaerisch, Stefan [Verfasser]. "Model-driven test case construction by domain experts in the context of software system families / Stefan Bärisch." Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019865997/34.
Full textJani, Divyang. "Structure and function of Sus1, Cdc31 and the Sac3 CID domain in mRNA export and gene-gating." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611632.
Full textHellmann, Jonathon David. "DataSnap: Enabling Domain Experts and Introductory Programmers to Process Big Data in a Block-Based Programming Language." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/54544.
Full textMaster of Science
Messai, Nizar Napoli Amedeo. "Analyse de concepts formels guidée par des connaissances de domaine Application à la découverte de ressources génomiques sur le Web /." S. l. : Nancy 1, 2009. http://www.scd.uhp-nancy.fr/docnum/SCD_T_2009_0018_MESSAI.pdf.
Full textNassiet, Didier. "Contribution à la méthodologie de développement des systèmes experts application au domaine du diagnostic technique /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37608383n.
Full textAbd-el-Kader, Yann. "Conception et exploitation d'une base de métadonnées de traitemets informatiques, représentation opérationnelle des connaissances d'expert : application au domaine géographique." Caen, 2006. http://www.theses.fr/2006CAEN2038.
Full textGeographical information is built, analyzed, transformed by computing programs. At the French National Mapping Agency (IGN), developers and users need assistance to seek, know and share these computing programs. The goal of our work is to provide this help, knowing that existing documentations are scattered, have heterogeneous formats and do not describe the data with all the desired smoothness. These documentations are also static : they cannot provide instructions adapted to the context of use (characteristics of the data, environment, user knowledge). However, since all the answers to the requests of the users cannot be stored in advance, it is necessary to implement mechanisms for derivate information. Facing this problem, we propose to exploit metadata with controlled structure and contents, in conformity with a model at the same time appropriate to the specificity of the geographical computing programs (precise description of the data’s properties before and after processing, illustrations) and designed for operational knowledge representation. We show the interest to follow a double approach. On one hand, we build a documentary Information System (IS) for metadata consultation and acquisition ; on the other hand, we build a Knowledge-Based System (KBS) dedicated to the simulation of the expert reasoning. The KBS is based on the standard languages of Semantic Web RDF, OWL and SWRL
Znaidi, Eya. "Contribution à l'analyse et l'évaluation des requêtes expertes : cas du domaine médical." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30054/document.
Full textThe research topic of this document deals with a particular setting of medical information retrieval (IR), referred to as expert based information retrieval. We were interested in information needs expressed by medical domain experts like praticians, physicians, etc. It is well known in information retrieval (IR) area that expressing queries that accurately reflect the information needs is a difficult task either in general domains or specialized ones and even for expert users. Thus, the identification of the users' intention hidden behind queries that they submit to a search engine is a challenging issue. Moreover, the increasing amount of health information available from various sources such as government agencies, non-profit and for-profit organizations, internet portals etc. presents oppor- tunities and issues to improve health care information delivery for medical professionals, patients and general public. One critical issue is the understanding of users search strategies and tactics for bridging the gap between their intention and the delivered information. In this thesis, we focus, more particularly, on two main aspects of medical information needs dealing with the expertise which consist of two parts, namely : - Understanding the users intents behind the queries is critically important to gain a better insight of how to select relevant results. While many studies investigated how users in general carry out exploratory health searches in digital environments, a few focused on how are the queries formulated, specifically by domain expert users. We address more specifically domain expert health search through the analysis of query attributes namely length, specificity and clarity using appropriate proposed measures built according to different sources of evidence. In this respect, we undertake an in-depth statistical analysis of queries issued from IR evalua- tion compaigns namely Text REtrieval Conference (TREC) and Conference and Labs of the Evaluation Forum (CLEF) devoted for different medical tasks within controlled evaluation settings. - We address the issue of answering PICO (Population, Intervention, Comparison and Outcome) clinical queries formulated within the Evidence Based Medicine framework. The contributions of this part include (1) a new algorithm for query elicitation based on the semantic mapping of each facet of the query to a reference terminology, and (2) a new document ranking model based on a prioritized aggregation operator. we tackle the issue related to the retrieval of the best evidence that fits with a PICO question, which is an underexplored research area. We propose a new document ranking algorithm that relies on semantic based query expansion leveraged by each question facet. The expansion is moreover bounded by the local search context to better discard irrelevant documents. The experimental evaluation carried out on the CLIREC dataset shows the benefit of our approaches
He, Xiong-wei. "Apport de l'analyse de raisonnement dans la conception d'un tutoriel intelligent indépendant du domaine d'expertise." Lyon, INSA, 1992. http://www.theses.fr/1992ISAL0037.
Full textThis thesis take into account the problem of using the knowledge base on an expert system for tutoring purposes. We have studied different aspects in the design of a domain-independent tutoring system capable to organize learning courses from a knowledge base (KB). Through a preliminary analysis of the knowledge base, we can obtain a set of reason trees which can be considered as a set of cases deducted from expert's knowledge. We have introduced the concept of reasoning path to represent expert's reasoning in a particular case. The set of reasoning paths of a KB can be used as the material for learning. In our tutoring system, named PEDASYS, three learning modes have been designed: 1) the Exploration mode give to learner the possibility to discover, in proper way, all the expert's knowledge of the KB. 2) the Query mode offer to learner with the possibility to ask Questions about subjects which are interesting for him. 3) the Training mode use the case-study method to organize a more systematic learning In PEDASYS, a student model is constructed and updated in different courses. This model is used to choose new cases to study. Pedagogical strategies come into work in this situation, for instance: find a counter-exemple, give to learner the chance to work on a particular rule to deal with one of his weak points, or choose the most interesting case for him, etc. .