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Journal articles on the topic 'Domaine rifain'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Qi, Xiaofeng, Wei Lin, Miaolian Ma, et al. "Structural basis of rifampin inactivation by rifampin phosphotransferase." Proceedings of the National Academy of Sciences 113, no. 14 (2016): 3803–8. http://dx.doi.org/10.1073/pnas.1523614113.

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Rifampin (RIF) is a first-line drug used for the treatment of tuberculosis and other bacterial infections. Various RIF resistance mechanisms have been reported, and recently an RIF-inactivation enzyme, RIF phosphotransferase (RPH), was reported to phosphorylate RIF at its C21 hydroxyl at the cost of ATP. However, the underlying molecular mechanism remained unknown. Here, we solve the structures of RPH from Listeria monocytogenes (LmRPH) in different conformations. LmRPH comprises three domains: an ATP-binding domain (AD), an RIF-binding domain (RD), and a catalytic His-containing domain (HD).

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2

Kaur, Jasweer, and Rachna Hora. "‘2TM proteins’: an antigenically diverse superfamily with variable functions and export pathways." PeerJ 6 (May 11, 2018): e4757. http://dx.doi.org/10.7717/peerj.4757.

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Malaria is a disease that affects millions of people annually. An intracellular habitat and lack of protein synthesizing machinery in erythrocytes pose numerous difficulties for survival of the human pathogenPlasmodium falciparum. The parasite refurbishes the infected red blood cell (iRBC) by synthesis and export of several proteins in an attempt to suffice its metabolic needs and evade the host immune response. Immune evasion is largely mediated by surface display of highly polymorphic protein families known as variable surface antigens. These include the two trans-membrane (2TM) superfamily

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3

Pramitha, Devi. "KH. ACHMAD ZAMACHSYARI, LEADERSHIP, AND MODERNIZATION OF PESANTREN: Character Study in Al-Rifa’ie Modern Islamic Boarding School of Malang." ULUL ALBAB Jurnal Studi Islam 22, no. 1 (2021): 115–41. http://dx.doi.org/10.18860/ua.v22i1.11678.

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KH. Achmad Zamachsyari or Gus Mad became one of the initiators to make changes by establishing a modern Islamic boarding school in Malang. He leads, provides a vision to move toward improvement and change. He chose an area in Ketawang, Gondanglegi, Malang to begin his struggle to build a modern Islamic boarding school. This study aims at obtaining a complete description of Gus Mad's leadership behavior; his interaction patterns; and modernization concept of Islamic boarding school education. The research design is qualitative and it uses the character study method. Gus Mad was chosen as the ob

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4

Harrison, Thomas E., Adam J. Reid, Deirdre Cunningham, Jean Langhorne, and Matthew K. Higgins. "Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite." Proceedings of the National Academy of Sciences 117, no. 50 (2020): 32098–104. http://dx.doi.org/10.1073/pnas.2016775117.

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The deadly symptoms of malaria occur as Plasmodium parasites replicate within blood cells. Members of several variant surface protein families are expressed on infected blood cell surfaces. Of these, the largest and most ubiquitous are the Plasmodium-interspersed repeat (PIR) proteins, with more than 1,000 variants in some genomes. Their functions are mysterious, but differential pir gene expression associates with acute or chronic infection in a mouse malaria model. The membership of the PIR superfamily, and whether the family includes Plasmodium falciparum variant surface proteins, such as R

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5

Mouna, Khalid. "Les nouvelles figures du pouvoir dans le Rif central du Maroc." Hors-thème 35, no. 1-2 (2011): 229–46. http://dx.doi.org/10.7202/1006388ar.

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En s’appuyant sur un travail de terrain, cet article revient sur la question du pouvoir dans la société rifaine. L’émergence de l’économie du kif et de ses dérivés dans le Rif central a bouleversé les rapports socioéconomiques de cette société. Les valeurs du passé qui constituaient les fondements du pouvoir – l’honneur et la baraka comme capital symbolique qui se bâtissent autour de l’appropriation des terres et des femmes comme domaines de l’interdit – ont changé avec l’arrivée de l’économie du kif qui a permis l’ouverture du Rif vers le marché mondial. Cette ouverture n’est pas sans conséqu

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6

Villanueva, Maite, Ambre Jousselin, Kristoffer T. Baek, et al. "Rifampin ResistancerpoBAlleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulatorspxin Staphylococcus aureus." Journal of Bacteriology 198, no. 19 (2016): 2719–31. http://dx.doi.org/10.1128/jb.00261-16.

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ABSTRACTStaphylococcus aureusis capable of causing a remarkable spectrum of disease, ranging from mild skin eruptions to life-threatening infections. The survival and pathogenic potential ofS. aureusdepend partly on its ability to sense and respond to changes in its environment. Spx is a thiol/oxidative stress sensor that interacts with the C-terminal domain of the RNA polymerase RpoA subunit, leading to changes in gene expression that help sustain viability under various conditions. Using genetic and deep-sequencing methods, we show thatspxis essential inS. aureusand that a previously reporte

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7

McDermott, Patrick F., David G. White, Isabelle Podglajen, Michael N. Alekshun, and Stuart B. Levy. "Multidrug Resistance following Expression of the Escherichia coli marA Gene in Mycobacterium smegmatis." Journal of Bacteriology 180, no. 11 (1998): 2995–98. http://dx.doi.org/10.1128/jb.180.11.2995-2998.1998.

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ABSTRACT Expression of the Escherichia coli multiple antibiotic resistance marA gene cloned in Mycobacterium smegmatis produced increased resistance to multiple antimicrobial agents, including rifampin, isoniazid, ethambutol, tetracycline, and chloramphenicol. Cloned marR or marA cloned in the antisense direction had no effect. Resistance changes were lost with spontaneous loss of the plasmid bearing marA. A MarA mutant protein, having an insertional mutation within either of its two alpha-helices of the first putative helix-turn-helix domain, failed to produce the multiresistance phenotype in

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8

Stefan, Maxwell A., Fatima S. Ugur та George A. Garcia. "Source of the Fitness Defect in Rifamycin-ResistantMycobacterium tuberculosisRNA Polymerase and the Mechanism of Compensation by Mutations in the β′ Subunit". Antimicrobial Agents and Chemotherapy 62, № 6 (2018): e00164-18. http://dx.doi.org/10.1128/aac.00164-18.

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ABSTRACTMycobacterium tuberculosisis a critical threat to human health due to the increased prevalence of rifampin resistance (RMPr). Fitness defects have been observed in RMPrmutants with amino acid substitutions in the β subunit of RNA polymerase (RNAP). In clinical isolates, this fitness defect can be ameliorated by the presence of secondary mutations in the double-psi β-barrel (DPBB) domain of the β′ subunit of RNAP. To identify factors contributing to the fitness defects observedin vivo, severalin vitroRNA transcription assays were utilized to probe initiation, elongation, termination, an

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9

Zaghloul, Mohamed Najib, Angelida Di Staso, Rachid Hlila, Vincenzo Perrone, and Sonia Perrotta. "The Oued Dayr Formation: first evidence of a new Miocene late-orogenic cycle on the Ghomaride complex (Internal Domains of the Rifian Maghrebian Chain, Morocco)." Geodinamica Acta 23, no. 4 (2010): 185–94. http://dx.doi.org/10.3166/ga.23.185-194.

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10

Benzaggagh, Mohamed, Mohamed Oumhamed, Bruno Ferré, and Jean-Louis Latil. "Turonian cephalopods (ammonoids and a nautiloid) from the Wadi Daya Formation of the Talerzha Basin (South Riffian Ridges Domain, northern Morocco)." Cretaceous Research 74 (June 2017): 109–19. http://dx.doi.org/10.1016/j.cretres.2017.02.009.

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11

Winter, Gerhard, Satoru Kawai, Malin Haeggström, et al. "SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes." Journal of Experimental Medicine 201, no. 11 (2005): 1853–63. http://dx.doi.org/10.1084/jem.20041392.

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The surfaces of the infected erythrocyte (IE) and the merozoite, two developmental stages of malaria parasites, expose antigenic determinants to the host immune system. We report on surface-associated interspersed genes (surf genes), which encode a novel polymorphic protein family, SURFINs, present on both IEs and merozoites. A SURFIN expressed in 3D7 parasites, SURFIN4.2, was identified by mass spectrometric analysis of peptides cleaved off the surface of live IEs with trypsin. SURFINs are encoded by a family of 10 surf genes, including three predicted pseudogenes, located within or close to

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12

Haider, Muhammad Salman, Savitha De Britto, Geetha Nagaraj, et al. "Genome-Wide Identification, Diversification, and Expression Analysis of Lectin Receptor-Like Kinase (LecRLK) Gene Family in Cucumber under Biotic Stress." International Journal of Molecular Sciences 22, no. 12 (2021): 6585. http://dx.doi.org/10.3390/ijms22126585.

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Members of the lectin receptor-like kinase (LecRLKs) family play a vital role in innate plant immunity. Few members of the LecRLKs family have been characterized in rice and Arabidopsis, respectively. However, little literature is available about LecRLKs and their role against fungal infection in cucumber. In this study, 60 putative cucumber LecRLK (CsLecRLK) proteins were identified using genome-wide analysis and further characterized into L-type LecRLKs (24) and G-type LecRLKs (36) based on domain composition and phylogenetic analysis. These proteins were allocated to seven cucumber chromoso

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13

Hyun, Jae-Kyung, Fasséli Coulibaly, Adrian P. Turner, Edward N. Baker, Andrew A. Mercer, and Alok K. Mitra. "The Structure of a Putative Scaffolding Protein of Immature Poxvirus Particles as Determined by Electron Microscopy Suggests Similarity with Capsid Proteins of Large Icosahedral DNA Viruses." Journal of Virology 81, no. 20 (2007): 11075–83. http://dx.doi.org/10.1128/jvi.00594-07.

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ABSTRACT Orf virus, the prototype parapoxvirus, is responsible for contagious ecthyma in sheep and goats. The central region of the viral genome codes for proteins highly conserved among vertebrate poxviruses and which are frequently essential for viral proliferation. Analysis of the recently published genome sequence of orf virus revealed that among such essential proteins, the protein orfv075 is an orthologue of D13, the rifampin resistance gene product critical for vaccinia virus morphogenesis. Previous studies showed that D13, arranged as “spicules,” is necessary for the formation of vacci

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14

Yang, Jenny, Thirunavukkarasu Annamalai, Bokun Cheng, Srikanth Banda, Rakhi Tyagi, and Yuk-Ching Tse-Dinh. "Antimicrobial Susceptibility and SOS-Dependent Increase in Mutation Frequency Are Impacted by Escherichia coli Topoisomerase I C-Terminal Point Mutation." Antimicrobial Agents and Chemotherapy 59, no. 10 (2015): 6195–202. http://dx.doi.org/10.1128/aac.00855-15.

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ABSTRACTTopoisomerase functions are required in all organisms for many vital cellular processes, including transcription elongation. The C terminus domains (CTD) ofEscherichia colitopoisomerase I interact directly with RNA polymerase to remove transcription-driven negative supercoiling behind the RNA polymerase complex. This interaction prevents inhibition of transcription elongation from hypernegative supercoiling and R-loop accumulation. The physiological function of bacterial topoisomerase I in transcription is especially important for a rapid network response to an antibiotic challenge. In

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15

Volkova, Violetta N., and Arina S. Kudriavtceva. "Models for management of innovative activities on industrial enterprise." Open Education 22, no. 4 (2018): 64–73. http://dx.doi.org/10.21686/1818-4243-2018-4-64-73.

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Innovations were the source of development of all spheres of life activities at all times. At present, the management of any organization is greatly influenced by the active development of innovative technologies of the third and fourth industrial revolutions. At the same time, innovative technologies can have both positive and negative effects. Therefore, when managing innovation activities of an enterprise, the requirements for thoroughness of their analysis are increased. It is necessary to make decisions about the expediency of choosing innovations for a particular enterprise (organization

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16

Kwon, Dong H., M. P. Dore, J. J. Kim та ін. "High-Level β-Lactam Resistance Associated with Acquired Multidrug Resistance in Helicobacter pylori". Antimicrobial Agents and Chemotherapy 47, № 7 (2003): 2169–78. http://dx.doi.org/10.1128/aac.47.7.2169-2178.2003.

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ABSTRACT Four clinical Helicobacter pylori isolates with high-level resistance to β-lactams exhibited low- to moderate-level resistance to the structurally and functionally unrelated antibiotics ciprofloxacin, chloramphenicol, metronidazole, rifampin, and tetracycline. This pattern of multidrug resistance was transferable to susceptible H. pylori by natural transformation using naked genomic DNA from a clinical multidrug-resistant isolate. Acquisition of the multidrug resistance was also associated with a change in the genotype of the transformed multidrug-resistant H. pylori. DNA sequence ana

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17

Chuang, Duen-yau, Yung-chei Chien, and Huang-Pin Wu. "Cloning and Expression of the Erwinia carotovora subsp. carotovora Gene Encoding the Low-Molecular-Weight Bacteriocin Carocin S1." Journal of Bacteriology 189, no. 2 (2006): 620–26. http://dx.doi.org/10.1128/jb.01090-06.

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ABSTRACT The purpose of this study was to clone the carocin S1 gene and express it in a non-carocin-producing strain of Erwinia carotovora. A mutant, TH22-10, which produced a high-molecular-weight bacteriocin but not a low-molecular-weight bacteriocin, was obtained by Tn5 insertional mutagenesis using H-rif-8-2 (a spontaneous rifampin-resistant mutant of Erwinia carotovora subsp. carotovora 89-H-4). Using thermal asymmetric interlaced PCR, the DNA sequence from the Tn5 insertion site and the DNA sequence of the contiguous 2,280-bp region were determined. Two complete open reading frames (ORF)

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18

Lindell, Debbie, Etana Padan, and Anton F. Post. "Regulation of ntcA Expression and Nitrite Uptake in the Marine Synechococcus sp. Strain WH 7803." Journal of Bacteriology 180, no. 7 (1998): 1878–86. http://dx.doi.org/10.1128/jb.180.7.1878-1886.1998.

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ABSTRACT NtcA is a transcriptional activator involved in global nitrogen control in cyanobacteria. In the absence of ammonium it regulates the transcription of a series of genes encoding proteins required for the uptake and assimilation of alternative nitrogen sources (I. Luque, E. Flores, and A. Herrero, EMBO J. 13:2862–2869, 1994). ntcA, present in a single copy in the marine Synechococcus sp. strain WH 7803, was cloned and sequenced. The putative amino acid sequence shows a high degree of identity to NtcA from freshwater cyanobacteria in two functional domains. The expression ofntcA was neg

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19

Meier, Petra, and Wilfried Wackernagel. "Impact of mutS Inactivation on Foreign DNA Acquisition by Natural Transformation in Pseudomonas stutzeri." Journal of Bacteriology 187, no. 1 (2005): 143–54. http://dx.doi.org/10.1128/jb.187.1.143-154.2005.

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ABSTRACT In prokaryotic mismatch repair the MutS protein and its homologs recognize the mismatches. The mutS gene of naturally transformable Pseudomonas stutzeri ATCC 17587 (genomovar 2) was identified and characterized. The deduced amino acid sequence (859 amino acids; 95.6 kDa) displayed protein domains I to IV and a mismatch-binding motif similar to those in MutS of Escherichia coli. A mutS::aac mutant showed 20- to 163-fold-greater spontaneous mutability. Transformation experiments with DNA fragments of rpoB containing single nucleotide changes (providing rifampin resistance) indicated tha

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20

Zhou, Albert E., Andrea A. Berry, Jason A. Bailey, et al. "Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure." mSphere 4, no. 2 (2019). http://dx.doi.org/10.1128/msphere.00097-19.

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ABSTRACT The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure. Adult sera recognized and reacted with greater intensity

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21

Xu, Kai, Yiran Wang, Chen-Hsiang Shen, et al. "Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs." Nature Communications 12, no. 1 (2021). http://dx.doi.org/10.1038/s41467-021-24291-6.

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AbstractRIFIN, a large family of Plasmodium variant surface antigens, plays a crucial role in malaria pathogenesis by mediating immune suppression through activation of inhibitory receptors such as LAIR1, and antibodies with LAIR1 inserts have been identified that bind infected erythrocytes through RIFIN. However, details of RIFIN-mediated LAIR1 recognition and receptor activation have been unclear. Here, we use negative-stain EM to define the architecture of LAIR1-inserted antibodies and determine crystal structures of RIFIN-variable 2 (V2) domain in complex with a LAIR1 domain. These structu

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22

Maaté, Soufian, Francisco Javier Alcalá, Francesco Guerrera, et al. "The External Tanger Unit (Intrarif sub-Domain, External Rifian Zones, Morocco): an interdisciplinary study." Arabian Journal of Geosciences 10, no. 24 (2017). http://dx.doi.org/10.1007/s12517-017-3347-8.

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23

Cian, Melina B., Nicole P. Giordano, Revathi Masilamani, Keaton E. Minor, and Zachary D. Dalebroux. "Salmonella enterica Serovar Typhimurium Uses PbgA/YejM To Regulate Lipopolysaccharide Assembly during Bacteremia." Infection and Immunity 88, no. 1 (2019). http://dx.doi.org/10.1128/iai.00758-19.

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ABSTRACT Salmonella enterica serovar Typhimurium (S. Typhimurium) relies upon the inner membrane protein PbgA to enhance outer membrane (OM) integrity and promote virulence in mice. The PbgA transmembrane domain (residues 1 to 190) is essential for viability, while the periplasmic domain (residues 191 to 586) is dispensable. Residues within the basic region (residues 191 to 245) bind acidic phosphates on polar phospholipids, like for cardiolipins, and are necessary for salmonella OM integrity. S. Typhimurium bacteria increase their OM cardiolipin concentrations during activation of the PhoPQ r

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24

Kim, Juhyun, Angel Goñi-Moreno, and Víctor de Lorenzo. "Subcellular Architecture of the xyl Gene Expression Flow of the TOL Catabolic Plasmid of Pseudomonas putida mt-2." mBio 12, no. 1 (2021). http://dx.doi.org/10.1128/mbio.03685-20.

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ABSTRACT Despite intensive research on the biochemical and regulatory features of the archetypal catabolic TOL system borne by pWW0 of Pseudomonas putida strain mt-2, the physical arrangement and tridimensional logic of the xyl gene expression flow remains unknown. In this work, the spatial distribution of specific xyl mRNAs with respect to the host nucleoid, the TOL plasmid, and the ribosomal pool has been investigated. In situ hybridization of target transcripts with fluorescent oligonucleotide probes revealed that xyl mRNAs cluster in discrete foci, adjacent but clearly separated from the T

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25

Khil, Pavel P., Augusto Dulanto Chiang, Jonathan Ho, et al. "Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection." mBio 10, no. 5 (2019). http://dx.doi.org/10.1128/mbio.01822-19.

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ABSTRACT Strains of Pseudomonas aeruginosa with deficiencies in DNA mismatch repair have been studied in the context of chronic infection, where elevated mutational rates (“hypermutation”) may facilitate the acquisition of antimicrobial resistance. Whether P. aeruginosa hypermutation can also play an adaptive role in the more dynamic context of acute infection remains unclear. In this work, we demonstrate that evolved mismatch repair deficiencies may be exploited by P. aeruginosa to facilitate rapid acquisition of antimicrobial resistance in acute infection, and we directly document rapid clon

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