Academic literature on the topic 'Domenico La Bruna'

The documents relating to Giordano Bruno's eight-year long trial for heresy at the hands of first the Venetian and then the Roman Inquisition, and to his execution in the Campo dei Fiori in Rome on 17 February 1600, have been gradually coming to light since Bruno's first Italian biographer, Domenico Berti, started to publish them in 1876. They were finally gathered together over a number of years in the second half of the twentieth century, and expertly edited, by one of Italy's most prestigious historians, Luigi Firpo, who did not live to see the results of his work in print.

Background:Secukinumab (SEC) is the first interleukin-17A inhibitor showing efficacy in both ankylosing spondylitis (AS) and psoriatic arthritis (PsA) in randomised trials, but real-life data are lacking.Objectives:In this prospective observational study, we evaluated the effectiveness and safety of SEC in patients with AS and PsA in a real-life setting.Methods:From September 2018 to September 2019, data were collected from 168 consecutive outpatients at baseline (T0) and at 6 (T6) and 12 months (T12) after starting SEC (39 AS, 23%; 129 PsA, 77%).Results:Significant improvement was seen at T6 and T12 for all clinical variables, including TJC, SJC, ESR, CRP, DAPSA, ASDAS-CRP, and BASDAI, as well as in patient-reported outcomes such as VAS-pain. By multivariable regression analysis, in AS patients high BASDAI at T0 correlated with diagnostic delay (R2=0.4; p=0.009) and peripheral joint involvement (R2=0.4; p=0.04). During follow-up, reduction of BASDAI positively correlated with high ESR (R2=0.65; p=0.04). ASDAS-CRP at T0 positively correlated with high ESR (R2=0.34; p=0.004). Reduction of ASDAS-CRP from T0 to T6 correlated with current smoking status (R2=0.42; p=0.0005). In PsA patients, reduction of DAPSA score from T0 to T12 negatively correlated with the presence of metabolic syndrome (R2=0.41; p= 0.0025). Retention rate showed good drug survival and an influence of female sex (Figure 1) in the survival curve in only AS patients, but no differences based on BMI, gender and lines of treatment were observed (Figure 2). SEC was well tolerated: Eleven patients discontinued treatment for non-severe adverse events.Conclusion:We demonstrated the effectiveness and safety of SEC in patients with AS and PsA in a real-life setting for the first time. No gender differences were observed; however, less clinical improvement was seen in smokers and in patients with metabolic syndromeReferences:No references.Disclosure of Interests:Maria Sole Chimenti: None declared, giulia lavinia fonti: None declared, Paola Conigliaro: None declared, flavia sunzini: None declared, Rossana Scrivo: None declared, luca navarini: None declared, paola triggianese: None declared, giusy peluso: None declared, Palma Scolieri: None declared, rosalba caccavale: None declared, Andrea Picchianti-Diamanti: None declared, erica de martino: None declared, simonetta salemi: None declared, domenico birra: None declared, Alessio Altobelli: None declared, marino paroli: None declared, Vincenzo Bruzzese: None declared, Bruno Laganà: None declared, Elisa Gremese Speakers bureau: Abbvie, BMS, Celgene, Jannsen, Lilly, MSD, Novartis, Pfizer, Sandoz, UCB, fabrizio conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi, Antonella Afeltra: None declared, Roberto Perricone: None declared

Este trabajo propone una aproximación a la historiografía urbana en Toscana durante la Baja Edad Media. Su cronística se interpreta como resultado de dos fenómenos: la consolidación de Florencia como autoridad política hegemónica en la región y como principal foco cultural del humanismo italiano. Cada epígrafe está dedicado a las historias realizadas sobre una ciudad concreta, interpretándose el contexto de su elaboración, la relación existente entre el autor y los hechos narrados, las características literarias de la obra, su contenido, y las posibilidades y límites que ofrecen para el conocimiento histórico. El catálogo de autores y obras incluye una tipología de las mismas en función de la cronología abordada (periodizaciones acotadas, historias universales y sucesos concretos). Asimismo se precisa los métodos y técnicas de elaboración histórica empleados por los cronistas, y sus esfuerzos humanistas en el tratamiento de las fuentes y por conseguir un estilo literario de inspiración clásica.The aim of this article is to offer a closest view of the urban chronicles made in the Toscana during the transition from the Middle Ages to the Renaissance. The analysis is both historiographic and historic in order to achieve a better comprehension of these Works, taking into account the political evolution of the region and the cultural background that defines it. There for it must be kept in mind that during the Late Medieval Ages Florence gradually grows stronger as the govern authority within the region, as well as the main role in the Italian Humanism.Each one of the sections in this article studies one city. The first one studies the case of Florence, followed by the other cities in the Toscana: Arezzo, Pisa, Pistoia, Prat, San Miniato, Sienna (only city that stays away from the Florentine sovereignty, remaining as a republic) and Volterra. In each case it is studied the historic, institutional and cultural reality surrounding the redaction of the chronicles, the relation between the author and the facts he relates, the literary aspect of the chronicles, in addition its content is summarized, and finally the opportunities and boundaries that the chronicles can offer to the historic knowledge is valued.The chronicles are also classified attending to its characterization. A first differentiation appears when focusing into the way the chronicles deal with the information: some offer just statements that contain the news, with no explanatory recounting, in order to achieve objectivity (Annali Fiorentini, Annali Pisani, Annali Arretonirum); other are detailed essay containing the author’s most intimate feelings (Giovanni de Bonis, Baldasarre Boniaiuti, Antonio Ivani da Sarzana); and there are also Works that join together the explanatory narration with the transcription of public documents from the Comune (Giovanni Villani, Leonardo Bruni, Matteo Palmieri). In order to study this last type of chronicles its been followed the methodology by G. Arnaldi and M. Zabbia about the notary-chronicler, his academic education and notarial work, which leads them to act as attestor and to recount History based in reliable documentation.Another classification can be made according to the chronological period in each chronicle. The Universal Histories go back to the city founding during mythological era and ancient times; they have the most original historical conception, offering chronological frameworks, interpretations and purely humanistic styles (Ricordano Malispini, Baldasarre Bonaiuti, Giovanni Villano, Leonardo Bruni, Niccolò Machiavelli). On the other hand, the cronache cittadine focus in a very precise period and, mostly, contemporary to the writing (Bartolomeo di ser Gorello, Raniero Granchi, Gregorio Dati, Paolo di Tommaso Montauri, Domenico Buoninsegni, Sozomeno da Pistoia, Tommaso Fecini, Francesco Guicciardini). Finally, the ricordanze analyse a very specific and exceptional event (Alamanno Acciaioli, Luigi Guicciardini, Simone Peruzzi, Guccio Benvenuti, Antonio Ivani da Sarzana, Bastiano, Francesco Pezzati, Guasparri Spadari); belonging to this last group there are also some rhymed pieces (Carmen in victoriam Pisanorum, Ricordi di Firenze in 1459, Sacco di Prato de Stefano Guizzalotti). Besides all these chronicle types there are some others in the form of diaries and domestic chronicles (Ugolino di Niccolò Martelli, Matteo Castellani, Filippo Rinuccini).Finally the study focus in the methods and techniques used by the chroniclers in the elaboration of History. They make a record of what they see or know through probative testimonies (oral or written), valuing the document as a source for the elaboration of History. Besides the humanistic way in which the chroniclers handle the sources, they also make an effort to achieve a literary style of classic inspiration.

Background:Golimumab showed trial efficacy in subjects with active rheumatoid arthritis (RA) previously treated with TNF-inhibitors (TNFi); no trial data are available for psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).Objectives:To assess the effectiveness of golimumab after TNFi failure in patients with RA, PsA, or axSpA in a real-world setting.Methods:GO-BEYOND-Italy is an ongoing, multicenter, prospective, observational study of RA, PsA, or axSpA patients starting golimumab after TNFi failure. Patients were enrolled between July 2017 and December 2019, and followed for 1 year, with evaluations at 3, 6, and 12 months. This interim analysis estimates the effectiveness after 3 months of golimumab therapy. Differences from baseline were tested by paired t-tests.Results:193 patients were enrolled: 38 (19.7%) with RA (median age 54 years; median disease duration 9.5 years), 91 (47.2%) with PsA (median age 53 years; median disease duration 9.0 years) and 64 (33.2%) with axSpA (median age 54 years; median disease duration 7.2 years). Majority of the RA (73.7%), PsA (51.6%) and axSpA (53.1%) were females. Previous TNFi treatment included etanercept (44.6% of patients), adalimumab (42.0%), infliximab (8.8%) and certolizumab (4.7%). The main reason for switching to golimumab was loss of efficacy of TNFi (78.9% in RA, 83.5% in PsA, 75% in axSpA). Comorbidities were highly prevalent (RA 65.8%, PsA 65.9%, axSpA 75%); hypertension (31.1%), dyslipidaemia (13.5%), fibromyalgia (10.4%) were the most common ones. DAS28-CRP significantly reduced in RA and PsA (p<0.01) after 3 months of treatment. In RA, rates of DAS28-CRP remission and low disease activity (LDA) were 29.6% and 22.2%, respectively, and 65.2% of patients achieved good/moderate EULAR response. As for PsA, good/moderate EULAR response was observed in 78.8% of patients and 28% of patients achieved minimal disease activity. In axSpA, ASDAS-CRP (p<0.01), BASDAI (p<0.01) and ASAS-HI (p=0.032) significantly reduced; rates of ASDAS-CRP inactive disease and LDA were 15.2% and 26.1%, respectively; 14% of patients had a ≥50% improvement in baseline BASDAI. After 3 months of golimumab treatment, there was a decrease in the prevalence of enthesitis (32.9% to 16.5%), nail (17.6% to 12.9%) and skin psoriasis (42.4% to 34.1%) in PsA patients; the frequency of extra articular manifestations tended to decrease also in axSpA patients.Conclusion:Preliminary results of the GO-BEYOND-Italy study showed a good short-term effectiveness of golimumab in RA, PsA and axSpA after TNFi failure.Table 1.Effectiveness of golimumab at 3 months in the GO-BEYOND-Italy studyRheumatoid arthritis (n=38)Psoriatic arthritis (n=91)Axial spondyloarthritis (n=64)DAS28-CRP, mean (SD)n=27DAS28-CRP, mean (SD)n=47ASDAS-CRP, mean (SD)n=44V0 / V14.05 (0.8) / 3.10* (1.0)V0 / V13.66 (1.0) / 2.79* (1.2)V0 / V12.86 (1.0) / 2.33* (1.0)V1: DAS28-CRP disease activity, n (%)n=27V1: EULAR response, n (%)n=33V1: ASDAS-CRP disease activity, n (%)n=46Remission8 (29.6)Good16 (48.5)Inactive disease7 (15.2)Low disease activity6 (22.2)Moderate10 (30.3)Low disease activity12 (26.1)Moderate disease activity13 (48.1)No response7 (21.2)High disease activity22 (47.8)Very high disease activity5 (10.9)V1: EULAR response, n (%)n=23V1: MDA, n (%)n=75Good7 (30.4)Yes21 (28.0)BASDAI, mean (SD)n=50Moderate8 (34.8)V0 / V15.99 (2.1) / 4.92 (2.3)*No response8 (34.8)V1: BASDAI50, n (%)7 (14.0)ASAS-HI, mean (SD)n=48V0 / V110.67 (3.8) / 9.68 (4.6)^*p value for the difference from V0 <0.01. ^ p for the difference from V0=0.032Abbreviations: ASDAS: Ankylosing Spondylitis Disease Activity Score; ASAS-HI: Assessment of SpondyloArthritis international society Health Index; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; CRP: C-reactive protein; DAS: disease activity score; EULAR: European League Against Rheumatism; MDA: Minimal Disease Activity; SD: standard deviation; V0: baseline; V1: 3 months evaluation.Disclosure of Interests:Salvatore D’Angelo Speakers bureau: AbbVie, BMS, Celgene, Eli Lilly, Janssen, Merck, Novartis, Pfizer, UCB, Consultant of: AbbVie, BMS, Celgene, Eli Lilly, Janssen, Merck, Novartis, Pfizer, UCB, Enrico Tirri Speakers bureau: AbbVie, Eli Lilly, Novartis, Pfizer, Angela Maria Giardino Employee of: MSD Italia, Marco Matucci-Cerinic Speakers bureau: BMS, Pfizer, Actelion, Consultant of: Eli-Lilly, Celgene, Chemomab, CSL Behring, Grant/research support from: BMS, Pfizer, Celgene, CSL Behring, Lorenzo Dagna Consultant of: Abbvie, Amgen, Biogen, Bristol-Myers Squibb, Celltrion, Novartis, Pfizer, Roche, Sanofi-Genzyme, and SOBI, Leonardo Santo: None declared., francesco ciccia: None declared., Bruno Frediani: None declared., Marcello Govoni: None declared., Francesca Bobbio Pallavicini: None declared., Rosa Daniela Grembiale: None declared., Andrea Delle Sedie: None declared., Stefania Cercone Employee of: MSD Italia, RITA MULE’: None declared., Francesco Paolo Cantatore Speakers bureau: Pfizer, Sanofi Genzyme and Roche, Consultant of: Pfizer, Sanofi Genzyme and Roche outside this work., Rosario Foti: None declared., Elisa Gremese: None declared., Roberto Perricone: None declared., Fausto Salaffi: None declared., Ombretta Viapiana Speakers bureau: Novartis, UCB, Abbvie, MSD, Fresenius kabi, Gilead, Biogen, Consultant of: Novartis, Abbvie, Fresenius kabi, Gilead, Biogen, Alberto Cauli Speakers bureau: Abbvie, Alfa-Sigma, BMS, Celgene, Galapagos, Glaxo, MSD, Novartis, Janssen, Pfizer, Sanofi, UCB, Consultant of: Abbvie, Alfa-Sigma, BMS, Celgene, Galapagos, Glaxo, MSD, Novartis, Janssen, Pfizer, Sanofi, UCB, Rorberto Giacomelli: None declared., Luisa Arcarese: None declared., Giuliana Guggino Speakers bureau: Novartis, Celgene, Abbvie, Sandoz, Eli Lilly, Pfizer, Jansen, ROMUALDO RUSSO: None declared., Domenico Capocotta: None declared., Francesca Nacci: None declared., Maria Grazia Anelli: None declared., valentina picerno: None declared., Florenzo Iannone Speakers bureau: Pfizer, AbbVie, Janssen, Celgene, Novartis, MSD, BMS, UCB, Roche, Consultant of: Pfizer, AbbVie, Janssen, Celgene, Novartis, MSD, BMS, UCB, Roche outside this work.

This work collects and analyzes a large corpus of Italian sources, both visual and literary, having as subject the black populations of colonial Africa. The research investigates specifically the sources of the fascist period (1922-1943). It examines various kinds of images, such as works of art, graphic works in illustrated magazines, commercial art and illustrations for children, as well as many articles taken by old Italian magazines and newspapers. The work wants to frame the various sources critically and to outline the evolution of some stereotypes related to the black colonial population and produced by an Eurocentric point of view. The first chapter presents the methodology which has been used to set the work; the second one, instead, is divided into two sections: the one contextualizes the European art with exotic subject and, specifically, the Orientalism trend and some of its Italian members; the other is devoted to the presentation of the artistic debate related to the Italian colonial artworks of the fascist period. The third chapter, which is the core of the work, is divided into various sections, which analyze the different male and female stereotypes emerged from the observation of images and texts. The study takes account of some historical situations, such as the Italo-Ethiopian wars of the late nineteenth century and of the 1935-36 biennium, which contributed to the spread of many clichés and iconographies about the black populations. The research also offers information about many of the Italian artists mentioned: these notes are useful for the comprehension of the fascist colonial art, of its exhibitions and its protagonists. The last part of the work presents the bibliography, a selection of the artistic and ethnographic articles found during the researches and used in the work, and the catalogue of the illustrations, which consists in a selection of over eight hundred images.
Il presente lavoro è dedicato alla raccolta e all'€™analisi di un nutrito corpus di fonti visive e letterarie italiane, aventi come soggetto le popolazioni nere dell'€™Africa durante il periodo coloniale; l'arco cronologico indagato è, nello specifico, quello del Ventennio fascista (1922-1943). La ricerca prende in esame svariate tipologie di veicoli delle immagini, quali opere d'arte, riviste illustrate e grafica per l'infanzia, nonché numerosi articoli d'epoca tratti da riviste e quotidiani. Lo scopo del lavoro è quello di indagare le diverse modalità  di rappresentazione dell'alterità nera, al fine di mettere in luce i pregiudizi e gli stereotipi generati dalla visione eurocentrica. Prima di passare alla disamina dei diversi clichés emersi dall'insieme delle immagini reperite, il lavoro propone un capitolo introduttivo, dedicato a presentare la metodologia con la quale è stata impostata la ricerca. Il secondo capitolo è suddiviso in due sezioni, l'una rivolta alla contestualizzazione dell'€™arte a soggetto esotico, della corrente ottocentesca dell'€™Orientalismo e di alcuni suoi esponenti italiani, l'altra riservata alla presentazione del dibattito in merito all'arte a soggetto coloniale nell'ambito della critica d'€™arte del Ventennio. Il terzo capitolo, suddiviso anch'€™esso in diverse sezioni, analizza gli stereotipi maschili e femminili emersi dall'osservazione delle immagini e dalla lettura dei testi d'epoca, tenendo conto di alcuni particolari frangenti storici, quali le guerre italo-etiopiche del tardo Ottocento e del biennio 1935-36, che hanno contribuito alla diffusione di determinati soggetti e iconografie. Il lavoro propone, oltre all'analisi delle immagini, notizie in merito a molti degli artisti citati, utili per comprendere l'arte coloniale del periodo fascista e le vicende dei suoi protagonisti. Concludono il lavoro l'apparato bibliografico, una parte dello spoglio degli articoli d'epoca rintracciati, divisi in fonti a tema artistico e fonti a soggetto etnografico, e il catalogo delle illustrazioni, consistente in una selezione di oltre ottocento elementi.

Although Abstract Art dominated the scene following the Second World War, four artists Bruno Goller, Domenico Gnoli, Konrad Klapheck and Peter Klasen concentrated, quite independently of one another, on the representational. Indeed their contributions may be classified as part of a wave appearing during the twentieth century, “Magical Monumentalism”. Objects from everyday life were taken and then isolated, enlarged, reduced, abstracted and defamiliarized, while still remaining recognisable in their own right. They each selected certain things, which were then variegated within their range of works. Visual moments and shop window scenes in the case of Goller, the gigantically magnified details of everyday life items with Gnoli, Klapheck’s personified machines and Klasen’s closed and impersonal objects. There exists basic criteria unifying the four artists: man defines himself through his own created works. Goller, Gnoli, Klapheck and Klasen negate man for the most part, or make him anonymous as an individual. They employ everyday objects at a time where Abstract Art dominates the scene, thereby monumentalizing them on differing degrees of scale. Yet in spite of the down to earth, rational appearance and superiority, the items used are magical in the sense of the magic of things. The definition of the objects is one of precise, perfect, while simultaneously showing them as open and rational. By means of picture analysis and interpretation, these features are highlighted. Definitions and historical background are also part and parcel of this. An approach to the theme of man, monumentality and the relevance to the present day situation, always bearing in mind the magical aspects of the work, is an integral part of the thesis. Until now these artists were never brought together in such detail.