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West, Robert J., and Roz Fryer. "Ratings of Suitability of Probe Tones as Tonics after Random Orderings of Notes of the Diatonic Scale." Music Perception 7, no. 3 (1990): 253–58. http://dx.doi.org/10.2307/40285463.
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Playing an ascending or descending diatonic scale establishes a "tonal hierarchy" in which the major-mode tonic is judged by listeners as being in a tonal sense more stable than other notes (Krumhansl, 1983). This article describes a study in which listeners were asked to rate probe tones for suitability as tonics after presentation of a variety of "random" orderings of all seven notes of a given scale. The results indicate that even musically trained listeners do not differentiate the major-mode tonic as uniquely suitable as the tonal center. In fact the major-mode tonic, the mediant, the dominant, and the subdominant were considered equally suitable as tonics and together were given higher ratings than other notes from the scale, including what would be the tonic for the natural minor mode. Nonmusicians showed the same profile of responses as musicians. The results indicate that the time-order of notes is important to the perception of tonal hierarchy.
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Swinkin, Jeffrey. "About a Key." Journal of Musicology 34, no. 4 (2017): 515–58. http://dx.doi.org/10.1525/jm.2017.34.4.515.
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In the sonata practice of the mid-eighteenth century, composers frequently asserted the minor dominant prior to the major dominant in the second part of the exposition. Beethoven dramatized this technique in two senses: first, he used it after it had largely fallen out of fashion, thus affording it considerable dramatic impact (e.g., Piano Sonatas Ops. 2, no. 2, and no. 3); second, he graduated from using the “wrong” mode to the more radical technique of using the “wrong” key. For instance, for the secondary key of the Piano Sonatas Ops. 31, no. 1, and 53 (“Waldstein”), he substitutes the major mediant for the dominant. These and similar cases result in the deferred arrival of the tonic in the secondary theme of the recapitulation. Consequently, when the tonic belatedly arrives, the listener is more cognizant of it. In this way Beethoven brings the resolution of large-scale tonal dissonance to the fore. I suggest that such a tactic is metamusical—that Beethoven was in a sense writing music about music, about the relationship between a particular piece and the tonal and formal conventions it relies on and also problematizes. After presenting a number of such metamusical instances, this article traces the stages by which Beethoven “progressed” from the mid-eighteenth-century approach to sonata expositions to his more radical one; it then offers a typology of key-problematizing techniques. It concludes by briefly considering the extent to which these procedures can be squared with Schenkerian theory and its ideal of structural hearing.
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Man-Ching, Yu. "Transformations of diatonic materials and tonal procedures in Ligeti's 'Etude No. 15 White on White'." New Sound, no. 42 (2013): 117–38. http://dx.doi.org/10.5937/newso1341117m.
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This essay examines interrelationships of various diatonic materials that arise in Ligeti's Etude No. 15 "White on White", focusing on transformational properties between different diatonic trichords. Ligeti's distinctive treatments of diatonic materials reflect the utilization of triadic intervallic structures in transformational procedures. In particular, ic5 dominates in abundance, contributing to the consonant tonal property between various pitch-class transformations among trichords, and that some are smoothly interconnected by common tones for preserving diatonic coherent sound. Additionally, some transformations are analogous to tonal procedures - harmonies progress from tonic to dominant or subdominant and vice versa - that manifests Ligeti's pronounced reference to the context of the traditional common practice as three pitch-classes among the same types of trichords map onto each other solely by ic5. Along with the coherent diatonic sound that Ligeti forges, tonal contrasts are achieved through simultaneous tonal occurrences being established by transformed pitch-classes, forming tonal pairings in third relationship with ics 3 and 4 that illuminate the traditionalistic tonic and mediant linkage prevailing in the nineteenth century.
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Jagad, Karishma B., and Bhavesh H. Jagad. "Comparison of Median Motor Nerve Conduction Velocity in Dominant and Non-Dominant Hand of Normal Individual." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 7, no. 2 (2013): 21. http://dx.doi.org/10.5958/j.0973-5674.7.2.005.
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Anchieta, David C., and John R. Buck. "Improving the dominant mode rejection beamformer with median filtering." Journal of the Acoustical Society of America 146, no. 4 (October 2019): 3057. http://dx.doi.org/10.1121/1.5137606.
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Tsukahara, Masato, Isabel Fernandez, Yoshitsugu Sugio, and Kohei Shiota. "Median nodule of the upper lip: An autosomal dominant trait." American Journal of Medical Genetics 51, no. 1 (May 15, 1994): 13–15. http://dx.doi.org/10.1002/ajmg.1320510104.
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Simões, Cristina, Flamine Alary, Nina Forss, and Riitta Hari. "Left-Hemisphere-Dominant SII Activation after Bilateral Median Nerve Stimulation." NeuroImage 15, no. 3 (March 2002): 686–90. http://dx.doi.org/10.1006/nimg.2001.1007.
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Vaquero-Cristóbal, Raquel, Ignacio Martínez González-Moro, Fernando Alacid, and Esperanza Ros. "Efectos de la lateralidad sobre la flexibilidad, la fuerza-resistencia y el equilibrio en mujeres mayores activas (Effects of laterality on flexibility, strength-endurance and balance in active older women)." Retos, no. 27 (March 5, 2015): 127–30. http://dx.doi.org/10.47197/retos.v0i27.34362.
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Los componentes de las cualidades físicas de las personas mayores han sido evaluadas mediante numerosos test. No obstante, no se ha estudiado la influencia de la lateralidad sobre estas cualidades. El objetivo del presente trabajo fue analizar las diferencias en la extensibilidad, la fuerza-resistencia y el equilibrio asociadas a la lateralidad en un grupo de mujeres mayores activas. Sesenta y siete mujeres (media de edad: 66.61 ± 6.63 años) realizaron con ambas extremidades los test de flexión del tronco en silla, juntar las manos tras la espalda, flexión completa de brazo y flamenco. Se encontraron diferencias significativas (p<.001) en los test de flexión del tronco en silla y de juntar las manos tras la espalda, siendo mayores los valores cuando la pierna extendida era la no dominante (-2.35±.83 cm con la pierna dominante y -.15±.83 cm con la no dominante) y cuando el brazo situado arriba era el dominante (-10.49±1.26 cm con el brazo dominante frente a -16.74±1.16 cm con el no dominante), respectivamente. En los test de flexión completa de brazo (brazo dominante y no dominante: 23.25 ± .53 y 23.71 ± .51 repeticiones, respectivamente) y flamenco (pierna dominante y no dominante: 23.83 ± 2.63 y 23.10 ± 2.78 seg, respectivamente) no se encontraron diferencias significativas entre las ambas extremidades. En conclusión, en mujeres mayores activas hay una relación directa entre la lateralidad y la extensibilidad de las extremidades superiores e inferiores; pero no entre la lateralidad y la fuerza-resistencia o el equilibrio.Palabras clave. Condición física, capacidad física, dominancia, adulto mayor, gerontogimnasia.Abstract. Older people’ physical abilities have been evaluated with a lot of tests. However, it has not been studied the influence of laterality on these qualities. The aim of this study was to analyse flexibility, strength-endurance and balance differences based on laterality in a group of active women elderly. Sixty-seven women (mean age: 66.61 ± 6.63 years) did chair-sit and reach, back scratch, arm curl and flamenco tests with both extremities. It was found significant differences (p<.001) in chair-sit and reach and back scratch tests. The values were higher with the non-dominant leg (dominant and non-dominant leg: -2.35±.83 and -.15±.83 cm, respectively) and the dominant arm, (dominant arm: -10.49±1.26 cm; non-dominant arm: -16.74±1.16 cm) respectively. It was not found significant differences in the arm curl (dominant and non-dominant arm: 23.25 ± .53 and 23.71 ± .51 repetitions, respectively) and flamenco tests (dominant and non-dominant leg: 23.83 ± 2.63 and 23.10 ± 2.78 seg, respectively). In conclusion, there is a direct relation between the laterality and the upper and lower extremities extensibility in active women elderly; but there is not it between the laterality and the strength-endurance or balance.Keywords. Physical condition, physical ability, dominance, elderly, senior fitness.
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Özcan, Ayşe, Mehtap Malkoç Ozdirenç, and Fatma Akln. "Light Touch and Pain Sensation Differences between Dominant and Non-Dominant Hands of Healthy Subjects." British Journal of Hand Therapy 10, no. 3-4 (September 2005): 76–79. http://dx.doi.org/10.1177/1758998305010003-401.
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The aim of this study was to identify and document light touch and pressure pain threshold differences between the dominant and non-dominant hands of healthy subjects. Pressure pain threshold (dolorimeter) and light touch threshold (Semmes-Weinstein Monofilaments) in the median, ulnar and radial nerve distributions were tested on the dominant and non-dominant hands of 131 healthy subjects. Pressure pain testing showed significantly higher thresholds in the dominant hands than in the non-dominant hands. There were no statistically significant differences between dominant and non-dominant hands for light touch threshold.
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Gholampour, Vahid. "Exchange Rates and Dominant Macro Fundamental." International Journal of Financial Research 12, no. 4 (June 9, 2021): 250. http://dx.doi.org/10.5430/ijfr.v12n4p250.
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Various exchange rates are driven by different macro variables. This paper uses a measure of exchange rate informativeness about future macro fundamentals to identify the dominant macroeconomic fundamental of 120 currencies. Exchange rate informativeness is defined as the share of future fundamental shocks in the variance of exchange rate changes. The distribution of exchange rate informativeness shows that the median exchange rate informativeness about the dominant macro fundamental is 0.11. Moreover, the exchange rate of most high-inflation countries is driven by expectations of the price differential. Expectations of the relative output drive the currency of countries with high export concentration.
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Anchieta, David C., and John R. Buck. "Performance of the median dominant mode rejection beamformer against array element perturbations." Journal of the Acoustical Society of America 148, no. 4 (October 2020): 2477. http://dx.doi.org/10.1121/1.5146864.
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Schroeder, C. E., S. Seto, and P. E. Garraghty. "Emergence of Radial Nerve Dominance in Median Nerve Cortex After Median Nerve Transection in an Adult Squirrel Monkey." Journal of Neurophysiology 77, no. 1 (January 1, 1997): 522–26. http://dx.doi.org/10.1152/jn.1997.77.1.522.
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Schroeder, C. E., S. Seto, and P. E. Garraghty. Emergence of radial nerve dominance in median nerve cortex after median nerve transection in an adult squirrel monkey. J. Neurophysiol. 77: 522–526, 1997. Throughout the glabrous representation in Area 3b, electrical stimulation of the dominant (median or ulnar) input produces robust, short-latency excitation, evident as a net extracellular “sink” in the Lamina 4 current source density (CSD) accompanied by action potentials. Stimulation of the collocated nondominant (radial nerve) input produces a subtle short-latency response in the Lamina 4 CSD unaccompanied by action potentials and followed by a clear excitatory response 12–15 ms later. Laminar response profiles for both inputs have a “feedforward” pattern, with initial activation in Lamina 4, followed by extragranular laminae. Such corepresentation of nondominant radial nerve inputs with the dominant (median or ulnar nerve) inputs in the glabrous hand surface representation provides a likely mechanism for reorganization after median nerve section in adult primates. To investigate this, we conducted repeated recordings using an implanted linear multi-electrode array straddling the cortical laminae at a site in “median nerve cortex” (i.e., at a site with a cutaneous receptive field on the volar surface of D2 and thus with its dominant afferent input conveyed by the median nerve) in an adult squirrel monkey. We characterized the baseline responses to median, radial, and ulnar nerve stimulation. We then cut the median nerve and semi-chronically monitored radial nerve, ulnar nerve and median nerve (proximal stump) evoked responses. The radial nerve response in median nerve cortex changed progressively during the weeks after median nerve transection, ultimately assuming the characteristics of the dominant nerve profile. During this time, median, and ulnar nerve profiles displayed little or no change.
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Hongaiah, Deepak, Dinesh Kumar Sathanantham, and Spurthi Sanganbhonia. "Angry young man syndrome: anger based dominant hand injuries." International Surgery Journal 5, no. 12 (November 28, 2018): 3986. http://dx.doi.org/10.18203/2349-2902.isj20185031.
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Background: The incidence of self-inflicted anger related upper extremity injuries due to punching glass, involving dominant hand has increased in recent years even in our rural population of less than 1.5 million in District of Kolar, Karnataka, India. Although hospital stay is short, these patients require long term follow up, physiotherapy and occupational rehabilitation.Methods: This study is a case series involving a a retrospective analysis from June 1, 2015, to July 31, 2017. Our study involved only glass cut injury following an angry intention.Results: This study included 9 eligible patients who were all young male aged between 18 to 28 years (median age: 23.4 years) who had triggering factor before punching the glass pane. All patients had tendon injuries, flexors (n=4), extensor (n=3), both (n=2), muscle injuries (n=1), median nerve (n=2), radial artery (n=3). All injuries required operative intervention. Mean hospital stay was 5.2 days. Mean rehabilitation period was 5.2 months.Conclusions: These types of injuries can be prevented by regular counseling for stress/anger management as a part of rehabilitation to prevent further recurrences.
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Inukai, Yumi, Maiko Takeuchi, and Nobuo Kawabata. "A Dominant Figure Viewed based on Perceptual Segmentation with Illusory Stratification in Silhouettes-Is a Good Figure Dominant-." Journal of The Institute of Image Information and Television Engineers 60, no. 8 (2006): 1307–11. http://dx.doi.org/10.3169/itej.60.1307.
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Gibbs, Richard A. "Proof without Words: The Mediant Property." Mathematics Magazine 63, no. 3 (June 1, 1990): 172. http://dx.doi.org/10.2307/2691137.
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Gibbs, Richard A. "Proof without Words: The Mediant Property." Mathematics Magazine 63, no. 3 (June 1990): 172. http://dx.doi.org/10.1080/0025570x.1990.11977511.
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Schmeisser, Lauren, Elisabeth Andrews, John A. Ogren, Patrick Sheridan, Anne Jefferson, Sangeeta Sharma, Jeong Eun Kim, et al. "Classifying aerosol type using in situ surface spectral aerosol optical properties." Atmospheric Chemistry and Physics 17, no. 19 (October 12, 2017): 12097–120. http://dx.doi.org/10.5194/acp-17-12097-2017.
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Abstract. Knowledge of aerosol size and composition is important for determining radiative forcing effects of aerosols, identifying aerosol sources and improving aerosol satellite retrieval algorithms. The ability to extrapolate aerosol size and composition, or type, from intensive aerosol optical properties can help expand the current knowledge of spatiotemporal variability in aerosol type globally, particularly where chemical composition measurements do not exist concurrently with optical property measurements. This study uses medians of the scattering Ångström exponent (SAE), absorption Ångström exponent (AAE) and single scattering albedo (SSA) from 24 stations within the NOAA/ESRL Federated Aerosol Monitoring Network to infer aerosol type using previously published aerosol classification schemes.Three methods are implemented to obtain a best estimate of dominant aerosol type at each station using aerosol optical properties. The first method plots station medians into an AAE vs. SAE plot space, so that a unique combination of intensive properties corresponds with an aerosol type. The second typing method expands on the first by introducing a multivariate cluster analysis, which aims to group stations with similar optical characteristics and thus similar dominant aerosol type. The third and final classification method pairs 3-day backward air mass trajectories with median aerosol optical properties to explore the relationship between trajectory origin (proxy for likely aerosol type) and aerosol intensive parameters, while allowing for multiple dominant aerosol types at each station.The three aerosol classification methods have some common, and thus robust, results. In general, estimating dominant aerosol type using optical properties is best suited for site locations with a stable and homogenous aerosol population, particularly continental polluted (carbonaceous aerosol), marine polluted (carbonaceous aerosol mixed with sea salt) and continental dust/biomass sites (dust and carbonaceous aerosol); however, current classification schemes perform poorly when predicting dominant aerosol type at remote marine and Arctic sites and at stations with more complex locations and topography where variable aerosol populations are not well represented by median optical properties. Although the aerosol classification methods presented here provide new ways to reduce ambiguity in typing schemes, there is more work needed to find aerosol typing methods that are useful for a larger range of geographic locations and aerosol populations.
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Alarcon, Renata Trigueirinho, Artur da Rocha Corrêa Fernandes, Ieda Maria Laurindo, Manoel Barros Bértolo, Geraldo Castelar Pinheiro, and Luís Eduardo Andrade. "Characterization of Cumulative Joint Damage Patterns in Patients with Rheumatoid Arthritis: A Clinical, Serological, and Gene Polymorphism Perspective." Journal of Rheumatology 42, no. 3 (February 1, 2015): 405–12. http://dx.doi.org/10.3899/jrheum.131177.
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Objective.To characterize cumulative joint damage (CJD) patterns in rheumatoid arthritis (RA) and determine their associations with demographic/clinical features and HLA-DRB1 gene polymorphism.Methods.Hand and foot radiographs were obtained from 404 patients with RA. CJD patterns were determined by 3 derivations from Sharp/van der Heijde scores, obtained by the mathematical division of scores for hands/feet (Sharp-h/f score), fingers/wrists (Sharp-f/w score), and erosion/space narrowing (Sharp-e/sn score), respectively. DNA and serum were obtained for determination of HLA-DRB1 polymorphism, rheumatoid factor (RF), and anticitrullinated protein antibodies (ACPA).Results.Patients with wrist-dominant CJD pattern were more likely to have severe RA than those with finger-dominant pattern (68.4% vs 46.0%; p = 0.036) as were those with foot-dominant vs hand-dominant CJD pattern (76.5% vs 56.4%; p = 0.044). HLA-DRB1 shared epitope (SE) alleles were associated with erosion-dominant CJD pattern (p = 0.021). Patients with erosion-dominant CJD pattern had higher levels of RF and ACPA than those with space-narrowing–dominant CJD pattern (median RF 71.35 U/ml vs 22.05 U/ml, respectively; p = 0.003; median ACPA 187.9 U/ml vs 143.2 U/ml, respectively; p < 0.001). The majority of triple-positive patients (SE+, RF+, ACPA+) had erosion-dominant CJD pattern (62.3%) while the majority of triple-negative patients (SE–, FR–, ACPA–) had space narrowing–dominant CJD pattern (75%; p = 0.017). ACPA was associated with HLA-DRB1 SE alleles (p < 0.05). Patients with foot-dominant CJD pattern were taller than those with hand-dominant CJD pattern (p = 0.002); those with erosion-dominant CJD pattern had higher weight and body mass index than those with space narrowing–dominant CJD pattern (p = 0.014, p = 0.001).Conclusion.CJD patterns were associated with disease severity, HLA-DRB1 SE status, presence and titer of ACPA and RF, and morphometric features.
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Zhang, Weiguo, Chelsea J. Stephens, Jon D. Blumenfeld, Ashkan Heshmatzadeh Behzadi, Stephanie Donahue, Warren O. Bobb, Jeffrey H. Newhouse, Hanna Rennert, Yize Zhao, and Martin R. Prince. "Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease." Journal of Magnetic Resonance Imaging 49, no. 3 (September 19, 2018): 894–903. http://dx.doi.org/10.1002/jmri.26289.
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Christopher Porter, J. W., and Carey G. Mellow. "Anatomically aberrant forearm arteries: an absent radial artery with co-dominant median and ulnar arteries." British Journal of Plastic Surgery 54, no. 8 (December 2001): 727–28. http://dx.doi.org/10.1054/bjps.2001.3706.
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Zabihhosseinian, Mahboobeh, Ryan Gilley, Danielle Andrew, Bernadette Murphy, and Paul Yielder. "Differential Changes in Early Somatosensory Evoked Potentials between the Dominant and Non-Dominant Hand, Following a Novel Motor Tracing Task." Brain Sciences 10, no. 5 (May 14, 2020): 290. http://dx.doi.org/10.3390/brainsci10050290.
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During training in a novel dynamic environment, the non-dominant upper limb favors feedback control, whereas the dominant limb favors feedforward mechanisms. Early somatosensory evoked potentials (SEPs) offer a means to explore differences in cortical regions involved in sensorimotor integration (SMI). This study sought to compare differences in SMI between the right (Dom) and left (Non-Dom) hand in healthy right-handed participants. SEPs were recorded in response to median nerve stimulation, at baseline and post, a motor skill acquisition-tracing task. One group (n = 12) trained with their Dom hand and the other group (n = 12), with their Non-Dom hand. The Non-Dom hand was significantly more accurate at baseline (p < 0.0001) and both groups improved with time (p < 0.0001), for task accuracy, with no significant interaction effect between groups for both post-acquisition and retention. There were significant group interactions for the N24 (p < 0.001) and the N30 (p < 0.0001) SEP peaks. Post motor acquisition, the Dom hand had a 28.9% decrease in the N24 and a 23.8% increase in the N30, with opposite directional changes for the Non-Dom hand; 22.04% increase in N24 and 24% decrease in the N30. These SEP changes reveal differences in early SMI between Dom and Non-Dom hands in response to motor acquisition, providing objective, temporally sensitive measures of differences in neural mechanisms between the limbs.
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DEPUYDT, K. H., A. H. SCHUURMAN, and M. KON. "Reversed Palmaris Longus Muscle Causing Effort-Related Median Nerve Compression." Journal of Hand Surgery 23, no. 1 (February 1998): 117–19. http://dx.doi.org/10.1016/s0266-7681(98)80241-6.
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Two cases of effort-related distal median nerve compression in the dominant forearm caused by a reversed palmaris longus muscle are presented. Simple resection of the muscle belly was performed. Carpal tunnel release was done in one case, but in retrospect this was probably not necessary.
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Purtill, Duncan, Marissa N. Lubin, Doris M. Ponce, Sergio Giralt, Miguel-Angel Perales, Richard J. O'Reilly, Marcel Van Den Brink, et al. "Analysis of 129 Myeloablative Double-Unit Cord Blood Transplantation Recipients Demonstrates an Independent Association Between Non-Dominant Unit TNC Dose and Engraftment Suggesting a Facilitation Effect." Blood 124, no. 21 (December 6, 2014): 2459. http://dx.doi.org/10.1182/blood.v124.21.2459.2459.
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Abstract Introduction: Double-unit cord blood (CB) transplantation (dCBT) has been investigated to augment engraftment in patients without an adequately dosed single CB unit. However, only one unit engrafts in the majority of patients and the role, if any, of the non-dominant unit is not established. Methods: To investigate whether the non-engrafting unit facilitates engraftment of the dominant unit, we studied 129 patients (median age 34 years, 76% > 16 years) who underwent myeloablative dCBT for hematological malignancies at our center in 10/2005-8/2013. Chimerism testing at 21 and 28 days after dCBT was used to identify dominant and non-dominant CB units which could be assigned even in cases of clinical graft failure based on bone marrow chimerism. Results: The cumulative incidence of neutrophil engraftment at day 45 was 95% (95%CI: 90-98) and occurred at a median of 24 days (range 12-43). The dominant CB unit was the only unit detected in the peripheral blood by day 28 in 111 patients (86%) whereas both the dominant and non-dominant units were detected in the remaining 18 patients [median non-dominant unit contribution to chimerism 20% (range 6-48)]. Recipients of units that had close unit-unit HLA- allele match (7-9/10 vs 1-6/10) were more likely to have both CB units detected at day 28 (27% vs 9%, respectively, p = 0.018). However, there was no engraftment advantage associated with persistence of the non-dominant unit 21-28 days post-dCBT with a median neutrophil recovery of 27 days (range 14-34) in those co-engrafting with both units vs 24 days (range 12-43) in those engrafting with a single unit. In univariate analyses, dominant unit infused total nucleated cell (TNC) dose, infused viable CD34+ cell dose, infused viable CD3+ cell dose, infused viable CD3-56+16+ cell dose, and percentage of viable CD34+ cells post-thaw (CD34+ cell viability) were all significantly associated with neutrophil engraftment. However, the TNC (Figure) and CD3+ cell doses of the non-dominant unit were also associated with neutrophil engraftment on univariate analysis [hazard ratio (HR) 1.35, p < 0.001 and HR 1.16, p < 0.001, respectively] whereas non-dominant unit CD34+ cell and CD3-56+16+ cell doses were not (HR 1.18, p = 0.107 and HR 1.06, p = 0.159, respectively). Neither donor-recipient HLA-match of dominant or non-dominant units, nor unit-unit HLA-match, were associated with time to neutrophil engraftment. Notably, on multivariate analysis, the dominant unit infused viable CD34+ cell dose, dominant unit CD34+ cell viability, and the non-dominant unit infused TNC dose were each independently associated with the speed and success of neutrophil engraftment (Table). To further assess potential effects of the non-dominant unit TNC dose, we evaluated the subset of patients in whom haematopoiesis by day 28 was purely derived from the dominant unit. Among these 111 patients, non-dominant unit TNC dose remained independently associated with engraftment in multivariate analysis (HR 1.21, p = 0.026). Finally, we hypothesized that the non-dominant unit TNC dose effect may be seen primarily in patients whose dominant units had a relatively low infused viable CD34+ dose. Indeed, analysis revealed the non-dominant unit TNC effect was only evident in the two-thirds of patients (n = 86) whose dominant unit infused viable CD34+ cell dose was low (< 1.20 x 105/kg, HR 1.37, p = 0.006). There was no association in patients whose dominant unit had a higher infused viable CD34+ cell dose (HR 1.03, p = 0.799). Conclusions: While infused viable CD34+ cell dose of the dominant unit is critical, the non-dominant unit TNC dose was also independently associated with neutrophil engraftment after dCBT. Therefore, despite their lack of engraftment, non-dominant units may facilitate engraftment of the dominant units in myeloablative dCBT recipients. These data suggest dCBT is associated with interactions that foster engraftment of the dominant unit. This finding supports continued investigation of dCBT, especially in adults who are more likely to receive units with low CD34+ cell doses. Furthermore, the mechanisms that underlie this observation warrant investigation. Table Table (n = 129 dCBT recipients) Multivariate Analysis HR 95% CI p value Dominant unit viable CD34+ cell x 105/kg (continuous) 1.72 1.41-2.10 < 0.001 Dominant unit CD34+ cell viability (%) 1.03 1.00-1.05 0.026 Non-dominant unit TNC x 107/kg (continuous) 1.19 1.01-1.40 0.035 Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Heuts, Simon G., Samuel S. Bruce, Brad E. Zacharia, Zachary L. Hickman, Christopher P. Kellner, Eric S. Sussman, Michael M. McDowell, Rachel A. Bruce, and E. Sander Connolly. "Decompressive hemicraniectomy without clot evacuation in dominant-sided intracerebral hemorrhage with ICP crisis." Neurosurgical Focus 34, no. 5 (May 2013): E4. http://dx.doi.org/10.3171/2013.2.focus1326.
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Object Large intracerebral hemorrhage (ICH), compounded by perihematomal edema, can produce severe elevations of intracranial pressure (ICP). Decompressive hemicraniectomy (DHC) with or without clot evacuation has been considered a part of the armamentarium of treatment options for these patients. The authors sought to assess the preliminary utility of DHC without evacuation for ICH in patients with supratentorial, dominant-sided lesions. Methods From September 2009 to May 2012, patients with ICH who were admitted to the neurological ICU at Columbia University Medical Center were prospectively enrolled in that institution's ICH Outcomes Project (ICHOP). Five patients with spontaneous supratentorial dominant-sided ICH underwent DHC without clot evacuation for recalcitrant elevated ICP. Data pertaining to the patients' characteristics and outcomes of treatment were prospectively collected. Results The patients' median age was 43 years (range 30–55 years) and the ICH etiology was hypertension in 4 of 5 patients, and systemic lupus erythematosus vasculitis in 1 patient. On admission, the median Glasgow Coma Scale (GCS) score was 7 (range 5–9). The median ICH volume was 53 cm3 (range 28–79 cm3), and the median midline shift was 7.6 mm (range 3.0–11.3 mm). One day after surgery, the median decrease in midline shift was 2.7 mm (range 1.5–4.6 mm), and the median change in GCS score was +1 (range −3 to +5). At discharge, all patients were still alive, and the median GCS score was 10 (range 9–11), the median modified Rankin Scale (mRS) score was 5 (range 5–5), and the median NIHSS (National Institutes of Health Stroke Scale) score was 22 (range 17–27). Six months after hemorrhage, 1 patient had died, 2 were functionally dependent (mRS Score 4–5), and 2 were functionally independent (mRS Score 0–3). Outcomes for the patients treated with DHC were good compared with 1) outcomes for all patients with spontaneous supratentorial ICH admitted during the same period (n = 144) and 2) outcomes for matched patients (dominant ICH, GCS Score 5–9, ICH volume 28–79 cm3, age < 60 years) whose cases were managed nonoperatively (n = 5). Conclusions Decompressive hemicraniectomy without clot evacuation appears feasible in patients with large ICH and deserves further investigation, preferably in a randomized controlled setting.
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Chun-Rong Huang, Yun-Jung Chang, Zhi-Xiang Yang, and Yen-Yu Lin. "Video Saliency Map Detection by Dominant Camera Motion Removal." IEEE Transactions on Circuits and Systems for Video Technology 24, no. 8 (August 2014): 1336–49. http://dx.doi.org/10.1109/tcsvt.2014.2308652.
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Angulo-Espinoza, Helmuth. "Traducir para perpetuar la ideología dominante: la traducción de Χριστός, ἀναστάσεως y ἀνάμνησις en la Vulgata." LETRAS, no. 56 (July 28, 2014): 91–109. http://dx.doi.org/10.15359/rl.2-56.4.
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La Vulgata ha desempeñado un papel decisivo en la vida litúrgica, espiritual, teológica y doctrinal en las diferentes iglesias cristianas occidentales. Ello se debe a las circunstancias sociopolíticas e ideológicas en las que vio la luz. Mediante la aplicación de los conceptos profesional, patrocinador y poética dominante, de André Lefevere, y el recurso al concepto althusseriano de ideología, el presente análisis sobre la traducción de tres términos neotestamentarios (Χριστός - ἀναστάσεως - ἀνάμνησις) procura demostrar cómo estas circunstancias entran en juego y favorecen la perpetuación de la cosmovisión dominante de quienes están en el gobierno de las instituciones eclesiásticas del siglo v.
The Vulgate has played a decisive role in liturgical, spiritual, theological and doctrinal life in different Western Christian churches, due to sociopolitical and ideological circumstances where it arose. Applying concepts of professional, sponsor and dominant poetics, from André Lefevere, and the concept of ideology from Althusser, this analysis of the translation of three new-testament terms (Χριστός - ἀναστάσεως - ἀνάμνησις) shows how these circumstances interact and favor the perpetuation of the dominant cosmovision of those who are governing ecclesiastical institutions in the fifth century.
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Zhang, Minfang, Wenyan Zhou, Shaojun Liu, Liyin Zhang, Zhaohui Ni, and Chuanming Hao. "KM55 Monoclonal Antibody Staining in IgA-Dominant Infection-Related Glomerulonephritis." Nephron 145, no. 3 (2021): 225–37. http://dx.doi.org/10.1159/000513269.
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<b><i>Introduction:</i></b> IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN), due to overlapping clinical and pathological features. The key factor in the pathogenesis of IgAN is galactose-deficient IgA1 (Gd-IgA1). However, the mechanism of glomerular IgA deposition in patients with IgA-IRGN is unclear. Therefore, we evaluated whether Gd-IgA1 could be a useful biomarker to distinguish between these 2 diseases. <b><i>Methods:</i></b> A case-control study was conducted to analyze the clinical and pathological characteristics of 12 patients with IgA-IRGN. The intensity and distribution of glomerular Gd-IgA1 (KM55) staining in renal biopsies were assessed. The control group consisted of 15 patients diagnosed with IgAN and an additional 17 patients with glomerulopathy involving IgA deposition. <b><i>Results:</i></b> The main clinical manifestations of patients with IgA-IRGN were nephrotic-range proteinuria, hematuria, acute renal injury, and hypocomplementemia. Active lesions were the leading pathological feature, while focal segmental sclerosis was rare. Half of the patients exhibited hump-shaped subepithelial deposits. Glomerular KM55 staining was negative in 7 patients, trace in 4 patients, and 2+ in 1 patient. The median intensity of KM55 staining in IgA-IRGN patients was 0 (range 0∼2+), which was significantly lower than that of primary IgAN patients (median 2+, range 1+∼3+). The receiver operating characteristic analysis demonstrated that the optimal cutoff level to identify these 2 diseases was 0.5+. <b><i>Conclusions:</i></b> Glomerular KM55 staining intensity might be helpful to distinguish IgA-IRGN from primary IgAN. Weak or negative staining may favor IgA-IRGN. In addition, integrated analysis including clinical data, pathological findings, and prognostic information would further improve the differential diagnosis.
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Vinh, Donald C., Smita Y. Patel, Gulbu Uzel, Victoria L. Anderson, Alexandra F. Freeman, Kenneth N. Olivier, Christine Spalding, et al. "Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia." Blood 115, no. 8 (February 25, 2010): 1519–29. http://dx.doi.org/10.1182/blood-2009-03-208629.
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Abstract We identified 18 patients with the distinct clinical phenotype of susceptibility to disseminated nontuberculous mycobacterial infections, viral infections, especially with human papillomaviruses, and fungal infections, primarily histoplasmosis, and molds. This syndrome typically had its onset in adulthood (age range, 7-60 years; mean, 31.1 years; median, 32 years) and was characterized by profound circulating monocytopenia (mean, 13.3 cells/μL; median, 14.5 cells/μL), B lymphocytopenia (mean, 9.4 cells/μL; median, 4 cells/μL), and NK lymphocytopenia (mean, 16 cells/μL; median, 5.5 cells/μL). T lymphocytes were variably affected. Despite these peripheral cytopenias, all patients had macrophages and plasma cells at sites of inflammation and normal immunoglobulin levels. Ten of these patients developed 1 or more of the following malignancies: 9 myelodysplasia/leukemia, 1 vulvar carcinoma and metastatic melanoma, 1 cervical carcinoma, 1 Bowen disease of the vulva, and 1 multiple Epstein-Barr virus+ leiomyosarcoma. Five patients developed pulmonary alveolar proteinosis without mutations in the granulocyte-macrophage colony-stimulating factor receptor or anti–granulocyte-macrophage colony-stimulating factor autoantibodies. Among these 18 patients, 5 families had 2 generations affected, suggesting autosomal dominant transmission as well as sporadic cases. This novel clinical syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern.
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Polage, Christopher R., Jonathan Grein, Margie Morgan, Sarah B. Doernberg, Steve Miller, Raymond Chinn, Cathy Woerle, et al. "839. Effect of Clostridioides difficile (C. difficile) Toxin Test Reporting on Clinical Treatment and Outcomes of Toxin-Negative PCR-Positive Patients at Five California Hospitals." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S10—S11. http://dx.doi.org/10.1093/ofid/ofz359.024.
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Abstract Background Guidelines support the use of toxin tests after C. difficile antigen detection or nucleic acid amplification tests (e.g., PCR) to help clinicians distinguish colonization from infection and reduce overdiagnosis but the safety of toxin-based diagnostic approaches remains controversial. Methods Five California hospitals monitored hospitalized adults with C. difficile testing before and after operational changes to reduce test-related overdiagnosis (2016–2018). Four added a toxin test to an existing GDH antigen/PCR-based approach and/or changed reporting to encourage the use of toxin results for clinical decision-making (i.e.,“toxin-dominant reporting”). One used the same test (toxin only) and reporting strategy throughout. All used a standardized tool to document clinical outcomes and treatment four days after testing (i.e., Day 5). Results In total, 1,034 patients had a Day 5 assessment with PCR-dominant reporting (pre-operational changes); 2,511 patients had a Day 5 assessment with toxin-dominant reporting (post-operational changes and single facility with no test change). Fewer Toxin-negative/PCR-positive (Toxin−/PCR+) patients received treatment with toxin-dominant reporting (median change: −52.1% [interquartile range (IQR): −35.1%, −69.1%]; aggregate P < 0.001). Day 5 outcomes were similar or better with toxin-dominant reporting despite less treatment. Patient discharge rates and in hospital diarrheal recovery was greater in the subset of Toxin−/PCR+ patients during the toxin-dominant reporting period: median discharge rate change = 8.8% [IQR: 1.5%, 11.9%] (aggregate P = 0.04); median diarrheal recovery rate change = 11.8% [IQR: 8.8%, 18.2%] (aggregate P = 0.018). Conclusion In a 5-center study, toxin-dominant test result reporting decreased anti-C. difficile treatment and improved discharge rates and diarrheal recovery in Toxin−/PCR+ patients. More work is needed to determine the rate of C. difficile-related adverse events in Toxin−/PCR+ patients. Disclosures All Authors: No reported Disclosures.
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Takahashi, Ryunosuke, Kohei Inoue, Kenji Hara, and Toru Hiraoka. "Generating Pixel Art by Noniterative Dominant Color Decision Algorithm." Journal of The Institute of Image Information and Television Engineers 74, no. 3 (2020): 597–600. http://dx.doi.org/10.3169/itej.74.597.
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GREENE, KENNETH F. "Opposition Party Strategy and Spatial Competition in Dominant Party Regimes." Comparative Political Studies 35, no. 7 (September 2002): 755–83. http://dx.doi.org/10.1177/0010414002035007001.
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This article provides a non-formal modification of the standard spatial model of party competition to make it more applicable to the study of opposition parties in dominant party systems in transition. Dominant parties' virtual monopoly over resources forces challengers to rely on activist-based strategies. Challengers then face the problem of balancing programmatically radical activists against the moderate preference of the median voter. The article shows that opposition parties' programmatic locations depend on the number of competing parties. Contrary to standard expectations, it finds that two-party competition between the incumbent and one challenger produces a center-fleeing strategy by the challenger, whereas three-party competition between the incumbent and two challengers yields center-seeking strategies by both challengers. The second half of the article applies this modified model to the case of Mexico. Data come from in-depth interviews, electoral returns, public opinion polls, and original sample surveys of national party leaders and activists.
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Felip, R. L., L. Barcelo, X. Binefa, and J. R. Kender. "Robust Dominant Motion Estimation Using MPEG Information in Sport Sequences." IEEE Transactions on Circuits and Systems for Video Technology 18, no. 1 (January 2008): 12–22. http://dx.doi.org/10.1109/tcsvt.2007.903804.
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Schroeder, C. E., S. Seto, J. C. Arezzo, and P. E. Garraghty. "Electrophysiological evidence for overlapping dominant and latent inputs to somatosensory cortex in squirrel monkeys." Journal of Neurophysiology 74, no. 2 (August 1, 1995): 722–32. http://dx.doi.org/10.1152/jn.1995.74.2.722.
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1. The pattern of reorganization in area 3b of adult primates after median or ulnar nerve section suggests that somatic afferents from the dorsum of the hand, carried by the radial nerve, have preferential access to the cortical territories normally expressing glabrous inputs carried by the median and ulnar nerves. A likely mechanism underlying preferential access is preexisting, but silent, radial nerve inputs to the glabrous region of cortex. 2. We tested this by comparing the effects of electrical stimulation of median or ulnar versus radial nerves, on responses in the hand representation of area 3b. Laminar current source density and multiunit activity profiles were sampled with the use of linear array multicontact electrodes spanning the laminae of area 3b. Data were obtained from three squirrel monkeys anesthetized during recording. 3. Compared with colocated median or ulnar nerve responses, the radial nerve response had 1) an initial short-latency response in the middle laminae that was subtle; there was a small transmembrane current flow component without a discernable multiunit activity correlate; and 2) a laminar sequence and distribution of activity that was similar to those of the median or ulnar nerve responses (i.e., initial activation of the middle, followed by upper and lower laminae), but the significant current flow and multiunit response to radial nerve stimulation occurs 12–15 ms later. 4. Normal corepresentation of nondominant dorsum hand (radial) inputs with the dominant (median or ulnar) inputs in the glabrous hand surface representation provides a clear vehicle for the biased patterns of reorganization occurring after peripheral nerve section. The initial, “subtle” activity phase in the nondominant response is believed to reflect intracortical inhibition, and the later “significant” response phase, a rebound excitation, possibly compounded by an indirect or extralemniscal input. The spatiotemporal pattern of nondominant input is proposed to play a role in normal somatosensory perception.
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Seeman, Tomáš, Magdaléna Fořtová, Bruno Sopko, Richard Průša, Michael Pohl, and Ulrike John. "Hypomagnesaemia is absent in children with autosomal dominant polycystic kidney disease." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 56, no. 1 (July 2, 2018): 90–94. http://dx.doi.org/10.1177/0004563218785190.
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Background Hypomagnesaemia is present in 40–50% of children with autosomal dominant renal cysts and diabetes syndrome (RCAD). On the contrary, the prevalence of hypomagnesaemia in children with autosomal dominant polycystic kidney disease (ADPKD) has never been examined. We aimed to investigate whether hypomagnesaemia is present in children with polycystic kidney diseases. Methods Children with cystic kidney diseases were investigated in a cross-sectional study. Serum concentrations of magnesium (S-Mg) and fractional excretion of magnesium (FE-Mg) were tested. Fifty-four children with ADPKD ( n = 26), autosomal recessive polycystic kidney disease (ARPKD) ( n = 16) and RCAD ( n = 12) with median age of 11.2 (0.6–18.6) years were investigated. Results Hypomagnesaemia (S-Mg < 0.7 mmol/L) was detected in none of the children with ADPKD/ARPKD and in eight children (67%) with RCAD. Median S-Mg in children with ADPKD/ARPKD was significantly higher than in children with RCAD (0.89 vs. 0.65 mmol/L, P < 0.01). The FE-Mg was increased in 23% of patients with ADPKD/ARPKD (all had chronic kidney disease stages 2–4) and in 63% of patients with RCAD, where it significantly correlated with estimated glomerular filtration rate (r = −0.87, P < 0.01). Conclusions Hypomagnesaemia is absent in children with ADPKD or ARPKD and could serve as a marker for differential diagnostics between ADPKD, ARPKD and RCAD in children with cystic kidney diseases of unknown origin where molecular genetic testing is lacking. However, while hypomagnesaemia, in the absence of diuretics, appears to rule out ADPKD and ARPKD, normomagnesaemia does not rule out RCAD at least in those aged <3 years.
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Boxer, Laurence A., Steven Stein, Danielle Buckley, Sandhya Subramanian, Audrey Anna Bolyard, Maynard V. Olson, and David C. Dale. "Unique Evidence for Autosomal Dominant Inheritance of Severe Congenital Neutropenia." Blood 104, no. 11 (November 16, 2004): 1457. http://dx.doi.org/10.1182/blood.v104.11.1457.1457.
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Abstract Severe congenital neutropenia was originally described as an autosomal recessive disorder characterized by severe neutropenia and recurrent bacterial infections from birth, but other reports indicate that autosomal dominant inheritance occurs. Several report now indicate that most, but not all, patients with severe congential neutropenia have heterozygous mutation in the gene for neutrophil elastase (NE or ELA2). We recently investigated an unusual series of cases of severe congenital neutropenia occurring when the same sperm donor was utilitized by four different families to impregnate mothers by either artificial insemination or in vitro fertilization. Three sets of twins were conceived and a single child in the four families. Collectively one set of twins and one child each from the other two families conceiving twins and the single child were all found to have severe congenital neutropenia. The mean for their median blood neutrophils (ANC) at diagnosis was 84 +/−32 x109/L (range 0–166 x 109 /L); and their other blood counts were remarkably similar. On treatment with G-CSF (mean dose 6.7+/− 1.3 SEM mcg/kg/day) the mean for the median ANC increased to 3290 +/−1410 x109/L( range 420–8600 x 109 /L ) To determine whether the sperm donor was responsible for transmitting severe congenital neutropenia, geonomic DNA from peripheral blood leukocytes was used to sequence the gene for neutrophil elastase in the affected children and their mothers using standard techniques. None of the mothers had a mutation in their NE gene but all five affected children had the same mutation effecting the fourth exon at site S97L. Since it was not possible to perform genetic analysis on biological samples from the donor, more detailed genetic linkage analysis was performed on the affected children and their mothers. Linkage mapping analysis of 22 microsatellite markers on chromosome 14 and 19 confirmed that all affected children possessed one of the two paternal alleles. For an 11 centiMorgan region immediately adjacent to the NE gene on chromosome 19, all affected children shared a single paternal allele, and 4 of 5 affected children shared a single paternal allele for a 20 centiMorgan region adjacent to the NE gene. The studies indicate that the father of the affected children provided consistent haplotypes that led to the expression of severe congenital neutropenia in all of the affected children. This investigation strongly implicates that autosomal dominant inheritance for severe congenital neutropenia. It also raises important questions for the evaluation of subjects in sperm donor programs.
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McMillan, HJ, MK Gillespie, KD Kernohan, R. Myer-Schuman, A. Antonellis, and KM Boycott. "P.070 Autosomal dominant MARS mutation linked to severe early onset CMT2U." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, s2 (June 2018): S34—S35. http://dx.doi.org/10.1017/cjn.2018.172.
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Background: Methionyl-tRNA synthetase (MARS) links methionine to its cognate tRNA required for translation. MARS mutations have been linked to adult-onset CMT2U. Methods: The proband had weakness in her first year of life, sitting at 11 months and walking at 20 months old. At 4 years old she was areflexic with distal > proximal weakness. Nerve conduction studies showed normal median and sural sensory responses with absent common peroneal, low median and tibial motor amplitudes. EMG noted denervation and quadriceps biopsy revealed neurogenic atrophy. Genetic testing for spinal muscular atrophy and sequencing of MNF2, RAB7A, LMNA, MPZ, HSPB1, NEFL, GADP1, TRPV4, HSPB8, GJB1 and PLEK8G5 were negative. She stopped walking at 9 years old and could not raise her arms above her head at 11 years old. Results: Exome sequencing identified MARS: c.1189G>A; p.Ala397Thr. To determine the functional consequences of p.A397T-MARS, yeast complementation assays were performed. Wild type or mutant MARS were cloned into yeast lacking the endogenous MARS ortholog. Wild-type MARS supported robust cellular growth, while the p.A397T-MARS insert did not support cellular growth confirming deleterious effect of this variant. Conclusions: Our patient’s phenotype was similar to children with motor-predominant GARS mutations. Functional data notes this MARS variant to be damaging and predictive of a severe, early-onset phenotype.
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Zeier, M., S. Geberth, A. Gonzalo, D. Chauveau, J. P. Grünfeld, and E. Ritz. "The effect of uninephrectomy on progression of renal failure in autosomal dominant polycystic kidney disease." Journal of the American Society of Nephrology 3, no. 5 (November 1992): 1119–23. http://dx.doi.org/10.1681/asn.v351119.
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The evolution of renal failure was compared in 47 patients (21 male, 26 female) with autosomal dominant polycystic kidney disease (ADPKD) in Germany, France, Spain, and Portugal who had undergone uninephrectomy (UNX) (median age at uninephrectomy, 41 yr; range, 22 to 54) and 47 non-UNX matched controls. UNX was usually performed because of uncontrolled urinary tract infection (N = 30), stones (N = 8), trauma (N = 2), or hemorrhage (N = 7). Median serum creatinine at UNX was 2.1 mg/dL (0.9 to 4.3). Twenty-eight of the 47 uninephrectomized patients progressed to end-stage renal failure. When the age at renal death was evaluated by survival analysis, only minor and nonsignificant acceleration was seen in the uninephrectomized patients (median, 50 yr; p25 = 43.6 yr; p75 = 58.3 yr, where p is the percentile) compared with non-UNX patients matched for age, sex, and serum creatinine at the time of UNX in the propositus (51.2 yr; p25 = 48.6 yr; p75 = 56.1 yr). In addition, the median interval for serum creatinine to rise from 4 to 8 mg/dL was similar in UNX (21.3 months) versus nonuninephrectomized ADPKD patients (21.9 months). Renal survival differed in the two genders. In females, no significant difference of age at renal death was found between UNX (median age, 51.6 yr) and non-UNX ADPKD patients (53.7 yr). In male UNX patients, age at renal death was slightly (but not significantly) less than in non-UNX patients (median age, 47.3 versus 52.7 yr). All male patients reaching end-stage renal failure before age 44 were severely hypertensive.
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Kraaikamp, Cor, Hitoshi Nakada, and Thomas A. Schmidt. "Metric and arithmetic properties of mediant-Rosen maps." Acta Arithmetica 137, no. 4 (2009): 295–324. http://dx.doi.org/10.4064/aa137-4-1.
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Gkourogianni, Alexandra, Melissa Andrew, Leah Tyzinski, Melissa Crocker, Jessica Douglas, Nancy Dunbar, Jan Fairchild, et al. "Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations." Journal of Clinical Endocrinology & Metabolism 102, no. 2 (November 21, 2016): 460–69. http://dx.doi.org/10.1210/jc.2016-3313.
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Abstract Context: Heterozygous mutations in the aggrecan gene (ACAN) cause autosomal dominant short stature with accelerated skeletal maturation. Objective: We sought to characterize the phenotypic spectrum and response to growth-promoting therapies. Patients and Methods: One hundred three individuals (57 females, 46 males) from 20 families with autosomal dominant short stature and heterozygous ACAN mutations were identified and confirmed using whole-exome sequencing, targeted next-generation sequencing, and/or Sanger sequencing. Clinical information was collected from the medical records. Results: Identified ACAN variants showed perfect cosegregation with phenotype. Adult individuals had mildly disproportionate short stature [median height, −2.8 standard deviation score (SDS); range, −5.9 to −0.9] and a history of early growth cessation. The condition was frequently associated with early-onset osteoarthritis (12 families) and intervertebral disc disease (9 families). No apparent genotype–phenotype correlation was found between the type of ACAN mutation and the presence of joint complaints. Childhood height was less affected (median height, −2.0 SDS; range, −4.2 to −0.6). Most children with ACAN mutations had advanced bone age (bone age − chronologic age; median, +1.3 years; range, +0.0 to +3.7 years). Nineteen individuals had received growth hormone therapy with some evidence of increased growth velocity. Conclusions: Heterozygous ACAN mutations result in a phenotypic spectrum ranging from mild and proportionate short stature to a mild skeletal dysplasia with disproportionate short stature and brachydactyly. Many affected individuals developed early-onset osteoarthritis and degenerative disc disease, suggesting dysfunction of the articular cartilage and intervertebral disc cartilage. Additional studies are needed to determine the optimal treatment strategy for these patients.
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Sun, Zimin, Huilan Liu, Liangquan Geng, Xin Liu, Huizhi Yang, and Zuyi Wang. "Transplantation of Multiple Cord Blood Units for Patients with Hematologic Malignancy." Blood 110, no. 11 (November 16, 2007): 5082. http://dx.doi.org/10.1182/blood.v110.11.5082.5082.
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Abstract Limited number of umbilical cord blood (UCB) cells indeed compromises the result of adult UCB transplantation. Therefore, to augment graft cell dose, we evaluated the safety and effectiveness of the combined transplantation of multiple partially HLA-match UCB units which was scarcely performed in china. After myeloablative conditioning, six patients with high-risk hematologic malignancy (median age, 29 years; range, 10–37 years) received two or three UCB units with at least one 5/6 HLA-match unit (median infused dose, 3.77×107 nucleated cell [NC]/kg; range, 3.40–7.49×107 NC/kg). Patients’ characteristics and transplantation data are detailed in Table 1. Five patients were engrafted successfully at a median of 22 days (range, 16–29 days) except one patient developed early graft failure (GF). In one patient, engraftment was derived from both donors for six months until her death. The both units’ were 6/6 HLA-A-, HLA-B-, and HLA-DRB1- matched the recipient’s, and they had similar number of nucleated cells, CD34 positive cells and CD3 positive cells. In the remaining four patients, Sustained hamatopoiesis was derived from a single donor which predominated as early as the day of engraftment after hematopoietic stem cell transplantation (HSCT). Units with a higher number of total nucleated cells and CD34+ cells predominated in two and one of four patients, respectively, and units with higher numbers of CD3+ cells predominated in three of four patients. The degree of HLA mismatch is also important (Table 2). Acute GVHD grades I-II was observed in the five patients. Two of them died of invasive fungus infection, one died of serious hepatitis, the remaining two patients were both alive and one survived in continuous complete remission 6 months after HSCT. Therefore, transplantation of multiple partly HLA-matched UCB units is a promising procedure to overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents. Patient characteristics and transplantation data Patients No. 1 No. 2 No. 3 No. 4 No. 5 No. 6 Age(years)/sex 37/F 30/M 32/M 27/M 10/M 10/F Body weight 64kg 84kg 69.5kg 56kg 32kg Diagnosis ALL ALL(Ph+) ANLL(M0) ALL ALL(Ph+) ANLL(M2) Pre-CBT status CR2 CR2 CR1 CR1 CR1 CR1 Conditioning TBI12GY/Ara-c/CY TBI12GY/Ara-c/CY TBI12GY/Ara-c/CY TBI12GY/Ara-c/CY BU/CY BU/CY/ATG Nucleated cells 3.51×107/kg 3.40×107/kg 3.43×107/kg 4.03×107/kg 6.28×107/kg 7.49×107/kg CD34+ cells 2.37×107/kg 2.75×105/kg 4.28×105/kg 2.22×105/kg 3.40×105/kg 5.51×105/kg ANC>0.5×109/L 21d 27d 16d 29d No 22d Plt>20×109/L 30d No No 46d No 30d Over survive 6M 60d 94d 4M+ 2M+ 1M+ Outcomes Death(hepatitis) Death(IFI) Death(IFI) Live GF Live Characteristics of dominant and non-dominant cord blood units Patients No. 2 No. 3 No. 4 No. 6 Nucleated cells(×107/kg) Dominant unit 1.14 1.88 1.33 3.79 Non-dominant unit1 0.94 1.55 1.45 3.7 Non-dominant unit2 1.32 CD34+ cells(×105/kg) Dominant unit 0.81 1.56 1.45 1.86 Non-dominant unit1 0.76 2.72 0.77 3.29 Non-dominant unit2 1.18 CD3+ cells(×107/kg) Dominant unit 0.27 0.53 0.42 0.68 Non-dominant unit1 0.14 0.4 0.34 0.63 Non-dominant unit2 0.34 Seratype (HLA-A,-B) and low-resolusion genotype (HLA-DR) mismatch Dominant unit 1/6. 1/6. 1/6. 0/6. Non-dominant unit1 1/6. 1/6. 1/6. 1/6. Non-dominant unit2 1/6.
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Sun, Zimin, Huilan Liu, Xingbing Wang, Liangquan Geng, Miao Zhou, and Zuyi Wang. "Double Cord Blood Transplantation in Hematologic Malignancy." Blood 112, no. 11 (November 16, 2008): 4426. http://dx.doi.org/10.1182/blood.v112.11.4426.4426.
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Abstract Purpose: Cord blood transplantation (CBT) is a promising alternative means of allogeneic stem cell transplantation. However, the limited cell dose of single umbilical cord blood (UCB) unit has been a major barrier to its more widespread use. With the hypothesis that double CBT (dCBT) could circumvent the cell dose problem, we analyzed the early engraftment kinetics in 10 hematologic malignancy patients given 2 partially matched dCBT. Methods: Patients were eligible for dCBT when a single 4-6/6 HLAmatched UCB unit with adequate nucleated cell dose is unavailable. From November 2005 to June 2008, 10 patients (3 male and 7 female) with a median age of 22 years (range 10–37) and a median weight of 55kg (range 31–70 kg) were recruited, including 4 ALL, 3 AML, and 3 CML. All patients received myeloablative conditioning (Flu/Cy/TBI for 6 patients, BU/CY2 for 2 and BU/CY2/BCNU for one). Graft versus host disease (GVHD) prophylaxis was CSA+MMF. They received two units with at least one 5/6 HLA-match unit. The median combined graft nucleated cell (NC) dose was 3.98°Á107/kg (range 3.51–7.70°Á107 NC/kg), and the median CD34+ cell dose was 2.37°Á105/Kg (range, 0.94–5.23°Á105/kg). Results: Eight patients (80%) had sustained hematopoietiec recovery. The median time to an absolute neutrophils count > 500 was 18 days (14'C29) and the median time to a platelet count > 20,000 was 34 days (27–46). Among those patients, one displayed the engraftment derived from both donors for six months until her death. The both units were 6/6 HLA matched the recipient, and had similar number of nucleated cells, CD34+ cells and CD3+ cells. The sustained hematopoiesis was derived from a single dominant one in the remianing 7 pateints. By STR-PCR, the median values of the percentage of the dominant unit was 80%(30–100%)at post-transplantatiom day 7, and they all achieve complete donor chimerism at day 28. The median infused cell dose of the predominating unit was 2.6°Á107 NC/Kg (range 1.3–4.45 °Á107/kg), 1.56°Á105 CD34+/Kg, (range 0.47–4.00°Á105/kg), and 0.53°Á107CD3+/Kg (range 0.34–2.59°Á107/kg), in contrast to 1.46°Á107 NC/Kg (range 0.96–6.09°Á107/kg), 0.87°Á105CD34+/Kg (range 0.20–2.55°Á105/kg), and 0.52°Á107CD3+/Kg (range 0.12–1.69°Á107/kg) in the nonsustained unit. When analyzed separately, units with high numbers of total nucleated cells, CD34+ cells or CD3+ cells dominate the engraftments in 4 partially overlapping patients. Only 3 of the 7 patients with donor engraftment received 2 UCB units with different degrees of HLA disparity. Of these, the better HLA-matched unit to the recipient predominated in 1 patients, while lesser matched units engrafted over the better matched units in 2 patients. Acute GVHD grade = 1 \* ROMAN ICIII was scored in 3 patients (37.5%) (1 grade = 1 \* ROMAN I, 1 grade II and 1 grade III). No patients presented acute GVHD grade IV. Three patients died (2 fungal infection, 1 serious hepatitis). Conclusions: Two units CBT is a safe and effective alternative option for hematologic malignancy treatment. Generally, hematopoiesis will be dominated by only one unit in patient received dCBT and it may occur as early as 7days after transplantation. However, the mechanism to determine this dominancy remains elusive, as nucleated cell dose, CD34+ cell dose, CD3+ graft cell dose and HLA match all failed to predict the predominant unit. Table 1 Characteistics of dominant and non-dominant cord blood units patients No1 No2 No3 No4 No5 No6 No7 TNC (°Á107/Kg) Dominant unit 1.3 2.7 3.79 2.6 4.45 2.3 2.48 Non-dominant unit 2.3 1.3 3.7 1.3 6.09 0.96 1.46 CD34 (°Á105/Kg) Dominant unit 1.56 0.77 1.82 1.85 4 0.74 0.47 Non-dominant unit 1.16 1.45 2.55 0.25 0.87 0.2 0.83 CD3 (°Á107/Kg) Dominant unit 0.53 0.34 0.74 2.59 0.35 0.42 0.83 Non-dominant unit 0.4 0.12 0.56 1.69 0.52 0.49 0.96 HLA mismatch Dominant unit 1/6 1/6 0/6 1/6 1/6 1/6 1/6
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Sekine, Akinari, Junichi Hoshino, Takuya Fujimaru, Tatsuya Suwabe, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, et al. "Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease." American Journal of Nephrology 51, no. 9 (2020): 745–51. http://dx.doi.org/10.1159/000509817.
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Background: Tolvaptan is the only therapeutic drug for autosomal dominant polycystic kidney disease (ADPKD). The influence of mutations in polycystic kidney disease 1 and 2 genes (PKD1 and PKD2) on the treatment effects of tolvaptan is not well documented in the literature. Methods: We retrospectively evaluated the relationship between genotype and the efficacy of tolvaptan in 18 patients with ADPKD who had been treated at Toranomon Hospital and undergone genetic testing between April 2016 and February 2020. Results: The annual change in estimated glomerular filtration rate (ΔeGFR/y) from before to after tolvaptan was from a median of −5.5 to −2.5 mL/min/1.73 m2 in the PKD1 truncating group, −3.3 to −2.4 mL/min/1.73 m2 in the PKD1 non-truncating group, −3.1 to −1.6 mL/min/1.73 m2 in the PKD2 group, and −1.9 to −2.6 mL/min/1.73 m2 in the group with no PKD1/2 mutation. The median degrees of improvement of ΔeGFR/y were 2.5 (45%), 0.4 (10%), 0.6 (28%), and −0.7 (−37%) mL/min/1.73 m2, respectively. Compared with the group of patients with any PKD1/2 mutation, the group with no PKD1/2 mutation showed significantly less improvement in ΔeGFR/y with tolvaptan (0.6 vs. −0.7 mL/min/1.73 m2, respectively; p = 0.01) and significantly less improvement in the annual rate of increase in total kidney volume (TKV) with tolvaptan (−6.7 vs. −1.1%, respectively; p = 0.02). Conclusion: Patients with ADPKD and no PKD1/2 mutation showed less improvement in ΔeGFR/y and the annual rate of increase in TKV with tolvaptan. Detecting PKD1/2 mutations may be useful for predicting the effectiveness of tolvaptan.
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Sellgren, Fredrik, Anna Koman, Erik Nordenström, Per Hellman, Joakim Hennings, and Andreas Muth. "Outcomes After Surgery for Unilateral Dominant Primary Aldosteronism in Sweden." World Journal of Surgery 44, no. 2 (November 11, 2019): 561–69. http://dx.doi.org/10.1007/s00268-019-05265-8.
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Abstract Background Primary aldosteronism (PA) is the most common cause of secondary hypertension. Surgery is the mainstay of treatment for unilateral dominant PA, but reported cure rates varies. The aim of the present study was to investigate contemporary follow-up practices and cure rates after surgery for PA in Sweden. Methods Patients operated for PA and registered in the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery (SQRTPA) 2009–2015 were identified. Patient data were extracted, and follow-up data (1–24 months) was recorded. Doses of antihypertensive medication and potassium supplementation were calculated using defined daily doses (DDD), and the Primary Aldosteronism Surgical Outcome (PASO) criteria were used to evaluate outcomes. Results Of 190 registered patients, 171 (47% female, mean age 53 years, median follow-up 3.7 months) were available for analysis. In 75 patients (44%), missing data precluded evaluation of biochemical cure according to the PASO criteria. Minimal invasive approach was used in 168/171 patients (98%). Complication rate (Clavien-Dindo >3a) was 3%. No mortality was registered. Pre/postoperatively 98/66% used antihypertensives (mean DDD 3.7/1.5). 89/2% had potassium supplementation (mean DDD 2.0/0) before/after surgery. Complete/partial biochemical and clinical success according to the PASO criteria were achieved in 92/7% and 34/60%, respectively. Conclusion In this study, reflecting contemporary clinical practice in Sweden complete/partial biochemical and clinical success after surgery for PA was 92/7% and 34/60%. Evaluation of biochemical cure was hampered by lack of uniform reporting of relevant outcome measures. We suggest mandatory reporting of surgical outcomes using the PASO criteria for all units performing surgery for PA.
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Besiris, D., A. Makedonas, G. Economou, and S. Fotopoulos. "Combining graph connectivity & dominant set clustering for video summarization." Multimedia Tools and Applications 44, no. 2 (May 12, 2009): 161–86. http://dx.doi.org/10.1007/s11042-009-0277-9.
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Murthy, R., Y. Oh, A. Tam, S. Gupta, D. C. Madoff, and B. Glisson. "Yttrium-90 microsphere treatment for liver dominant hepatic metastases from lung cancer." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 17122. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.17122.
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17122 Background: Hepatic metastases are a common manifestation of primary lung malignancies; the primary and other extrahepatic sites are often less responsive to systemic therapy. A new method of regional therapy for hepatic metastases, called SIR-Spheres, a 32μ resin sphere incorporating a pure Beta emitter, Yttrium - 90, has advantages to older forms of regional hepatic therapy, used to treat colorectal liver metastases. The effectiveness and relatively response durability suggests a favorable alternative to chemotherapy for patients with liver-dominant metastatic lung cancers. We report our experience using SIR-Spheres in this setting. Methods: 6 patients (2 well differentiated carcinoid, 2 well & 1 poorly differentiated adenocarcinoma, 1 poorly differentiated small cell carcinoma) with unresectable hepatic metastases were treated with 8 infusions of SIR-Spheres after failing systemic chemotherapy, radiofrequency ablation or arterial embolization were included in the study. SIR-Spheres were administered as 2nd-6th line therapy. Median interval from diagnosis to SIR-Spheres treatment was 20.5 months (6–51 m). Results: Abdominal visceral arteriography demonstrated vasculature conducive for SIR-Spheres delivery in all patients. The median dose of 36.1 mCi (12.9–54 mCi) was delivered. SPECT - CT fusion Bremsstrahlung scans post therapy confirmed preferential deposition of SIR-Spheres within metastases. Responses to therapy included a decrease in the size of the hepatic metastases in one patient and stable disease in two patients. One patient had a mixed response and two patients had progression of disease. One Gr. III and one Gr. IV hepatic toxicity occurred. All patients experienced transient Gr. 1 or 2 fatigue. Time to progression of liver disease ranged from 3 to 9 months. Conclusion: SIR-Spheres is a feasible alternative to systemic therapy for patients with liver dominant metastases from lung cancers. Although serious hepatotoxicity was noted in patients with advanced liver metastases, the treatment was tolerated with only reversible fatigue in the majority of patients. When the treatment was effective, the duration of local disease control after one treatment equaled or exceeded what would be expected with chemotherapy. [Table: see text]
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Chandler, Jessica, Michael Beets, Pedro Saint-Maurice, Robert Weaver, Dylan Cliff, Clemens Drenowatz, Justin Moore, Mei Sui, and Keith Brazendale. "Wrist-Based Accelerometer Cut-Points to Identify Sedentary Time in 5–11-Year-Old Children." Children 5, no. 10 (September 26, 2018): 137. http://dx.doi.org/10.3390/children5100137.
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Background: The objective of this paper is to derive a wrist-placed cut-point threshold for distinguishing sedentary behaviors from light-intensity walking using the ActiGraph GT3X+ in children. Methods: This study employed a cross-sectional study design, typically used in measurement-related studies. A sample of 167 children, ages 5–11 years (mean ± SD: 8.0 ± 1.8 years), performed up to eight seated sedentary activities while wearing accelerometers on both wrists. Activities included: reading books, sorting cards, cutting and pasting, playing board games, eating snacks, playing with tablets, watching TV, and writing. Direct observation verified sedentary behavior from light activity. Receiver operator characteristic (ROC) analyses were used to determine optimal cut-point thresholds. Quantile regression models estimated differences between dominant and non-dominant placement. Results: The optimal cut-point threshold for the non-dominant wrist was 203 counts/5 s with sensitivity, specificity, and area under the curve (AUC) of 71.56, 70.83, and 0.72, respectively. A 10-fold cross-validation revealed an average AUC of 0.70. Statistically significant (p ≤ 0.05) differences in median counts ranging from 7 to 46 counts/5 s were found between dominant and non-dominant placement in five out of eight sedentary activities, with the dominant wrist eliciting higher counts/5 s. Conclusion: Results from this study support the recommendation to place accelerometers on the non-dominant wrist to minimize “noise” during seated sedentary behaviors.
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Zhang, L., I. Cheng, D. Muir, and J. P. Charland. "Scavenging ratio of polycyclic aromatic compounds in rain and snow at the Athabasca oil sands region." Atmospheric Chemistry and Physics Discussions 14, no. 13 (July 28, 2014): 19395–429. http://dx.doi.org/10.5194/acpd-14-19395-2014.
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Abstract. Athabasca oil sands industry in northern Alberta, Canada is a possible source of polycyclic aromatic compounds (PACs). Monitored PACs, including polycyclic aromatic hydrocarbons (PAHs), alkylated PAHs, and dibenzothiophenes, in precipitation and in air at three near-source sites in the Fort MacKay and Fort McMurray area during May 2011 to August 2012 were analyzed to generate a database of scavenging (or washout) ratios (Wt) for PACs scavenged by both snow and rain. Median precipitation and air concentrations of parent PAHs over the May 2011 to August 2012 period ranged from 0.3–184.9 (chrysene) ng L−1 and 0.01–3.9 (naphthalene) ng m−3, respectively, which were comparable to literature values. Higher concentrations in precipitation and air were observed for alkylated PAHs and dibenzothiophenes. The median precipitation and air concentrations were 11.3–646.7 (C3-fluoranthene/pyrene) ng L−1 and 0.21–16.9 (C3-naphthalene) ng m−3, respectively, for alkylated PAHs, and 8.5–530.5 (C4-dibenzothiophene) ng L−1 and 0.13–6.6 (C2-dibenzothiophene) ng m−3 for dibenzothiophenes and their alkylated derivatives. Median Wt over the measurement period were 6100–1.1 × 106 from snow scavenging and 350–2.3 × 105 from rain scavenging depending on the PAC species. Median Wt for parent PAHs were within the range of those observed at other urban and suburban locations. But Wt for acenaphthylene in snow samples was 2–7 times higher. Some individual snow and rain samples exceeded literature values by a factor of 10. Wt for benzo(a)pyrene, dibenz(a,h)anthracene, and benzo(g,h,i)perylene in snow samples had reached 107, which is the maximum for PAH snow scavenging ratios reported in literature. From the analysis of data subsets, Wt for particulate-phase dominant PACs were 14–20 times greater than gas-phase dominant PACs in snow samples and 7–20 times greater than gas-phase dominant PACs in rain samples. Wt from snow scavenging was ∼9 times greater than rain scavenging for particulate-phase dominant PACs and 4–9.6 times greater than rain scavenging for gas-phase dominant PACs. Gas-particle fractions of each PAC, particle size distributions of particulate-phase dominant PACs, and Henry's Law constant of gas-phase dominant PACs explained, to a large extent, the different Wt values among the different PACs and precipitation types. This study verified findings from a previous study of Wang et al. (2014) which suggested that snow scavenging is more efficient than rain scavenging of particles for equivalent precipitation amount, and also provided new knowledge on the scavenging of gas-phase PACs by snow and rain.
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Lin, Xinfu, Yaobin Zhu, Jiewei Luo, and Jianbin Huang. "Genetic analysis of three families with X-linked dominant hypophosphatemic rickets." Journal of Pediatric Endocrinology and Metabolism 31, no. 7 (July 26, 2018): 789–97. http://dx.doi.org/10.1515/jpem-2017-0451.
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Abstract Background Hypophosphatemic rickets, including familial hypophosphatemic vitamin D-resistant rickets, which commonly manifests in childhood, is generally hereditary. X-linked dominant hypophosphatemic rickets (XLH, MIM307800), caused by inactivating mutations in the PHEX gene, is the most common form. This study aimed to identify the gene mutations responsible for three cases of XLH and its clinical phenotype. Methods We conducted a genetic diagnosis and clinical phenotypic linkage analysis of three pedigrees with XLH. Three probands finally diagnosed as XLH were analyzed by next-generation sequencing (NGS). Sanger sequencing was used for mutation scanning in other family members. Results For the three patients with XLH, the age of onset ranged from 1.5 to 2 years and their heights were less than three standard deviations (SDs) below the median. The patients exhibited curved deformities in both lower limbs, hypophosphatemia, elevated serum FGF23 levels and elevated levels of blood alkaline phosphatase, with normal levels of blood parathyroid hormone (PTH) and calcium. X-ray analysis of the limbs and chest revealed characteristic rickets signs. Three candidate pathogenic mutations were identified in PHEX (NM_000444.5): c.433G>T (p.Glu145*, p.E145*) in exon 4, c.1735G>A (p.Gly579Arg, p.G579R) (rs875989883) in exon 17 and c.2245T>C (p.Trp749Arg, p.W749R) in exon 22. The nonsense mutation (p.E145*) in PHEX is novel and is predicted to cause a truncation of the encoded protein, resulting in loss of function. Conclusions The novel nonsense mutation (p.E145*) in PHEX is possibly involved in inherited XLH.
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Cao, Jianbing. "Asymptotic Property of Mediant for Lagrange’s Mean Value Theorem." Journal of Mathematical Sciences and Applications 5, no. 1 (August 26, 2017): 27–29. http://dx.doi.org/10.12691/jmsa-5-1-5.
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Kovrigina, I. V., E. V. Bolotova, and A. V. Kontsevaya. "Use of the Dominant Component Analysis for Improvement of Preventive Measures in Patients with Cardiovascular Risks." Doctor.Ru 20, no. 4 (2021): 7–14. http://dx.doi.org/10.31550/1727-2378-2021-20-4-7-14.
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Study Objective: To improve efficiency of cardiovascular disease (CVD) prevention in patients with health category IIIa in Krasnodar Territorial Outpatient Clinic using a factorial analysis (dominant component analysis) of stage 1 health assessment results for 2015 and 2018. Materials and Methods. The study includes subjects who underwent stage 1 health assessment: 2015 — 2,461 people, 2018 — 2,772 people. Patients with health category IIIa were assessed for modifiable risk factors (RF) of CVDs using the dominant component analysis. Study Results. In 2015, health category IIIа was assigned to 29.9% of patients; female patients accounted for 68.5% (median age: 62 years), males accounted for 31.5% (median age: 60 years). In 2018, health category IIIа was recorded for 41.5% of patients; female patients accounted for 64.3% (median age: 63 years), males accounted for 35.7% (median age: 62 years). Factorial analysis demonstrated that male patients have the following composition of modifiable CVD RFs: factor 1 — improper diet (ID) and physical inactivity (PIA); factor 2 — hypercholesterolemia (HCS), tobacco smoking and alcohol abuse (TSAA); factor 3 — arterial hypertension (AH) and ID; factor 4 — AH. Women demonstrated different compositions of CVD RFs: factor 1 — ID and PIA; factor 2 — AH and HCS; factor 3 — BMI > 25 kg/m2 and hyperglycemia; factor 4 — TSAA. Conclusion. Gender differences together with modifiable CVD RFs in patients with risk category IIIa revealed with the help of the dominant component analysis allow correcting RFs taking into account combinations, most contributing to unfavourable cardiovascular events. Keywords: health assessment, risk factor, circulatory diseases, prevention, outpatient clinic, factorial analysis.