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Journal articles on the topic 'Donepezil HCl'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Sai Sreenidhi K and Anand Kumar Yegnoor. "Proniosomal gel mediated transdermal delivery of Donepezil HCl: Development and in vitro characterization." International Journal of Frontline Research in Pharma and Bio Sciences 2, no. 2 (2023): 017–23. http://dx.doi.org/10.56355/ijfrpbs.2023.2.2.0018.

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The aim of this research was to study the potential of proniosomal gel for transdermal delivery. Donepezil HCl loaded proniosomal gels were prepared by the coacervation phase separation method using different nonionic surfactants (spans and tweens). The prepared Donepezil HCl proniosomal gels were evaluated for various parameters such as particle size (PS), drug entrapment efficiency percentage (EE %), and in vitro drug release. Donepezil HCl loaded proniosomal gel was prepared successfully by coacervation phase separation method. The prepared proniosomal gel exhibited desired entrapment effic

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2

Chaudhari, Pallavi M. "Optimization and Evaluation of In situ Nasal Gel of Donepezil Hydrochloride." Asian Pacific Journal of Health Sciences 8, no. 2 (2021): 104–10. http://dx.doi.org/10.21276/apjhs.2021.8.2.20.

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Introduction: The nasal route has been explored as a route of administration, due to the benefits it offers. The formulation in the form of in situ gel has been utilized for the local and systemic effect. This type of formulation first exists in sol form, but once they are administered, it undergoes gelation to form gel, and this approach can be used for successful drug delivery system. Methods: Thus, in the present study, formulation of in situ gel for nasal administration for donepezil hydrochloride (HCL), by the use of 32 factorial designs, to improve its nasal bioavailability, was develope

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3

Tiseo, Rogers, and Friedhoff. "Pharmacokinetic and pharmacodynamic profile of donepezil HCl following evening administration." British Journal of Clinical Pharmacology 46, S1 (1998): 13–18. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1013.x.

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4

Dwiatmaka, Yohanes, Nunung Yuniarti, Endang Lukitaningsih, and Subagus Wahyuono. "Antioxidant Activity of Tempeh Ethanolic Extract on Male Swiss Mouse Brain." Majalah Obat Tradisional 28, no. 1 (2023): 10. http://dx.doi.org/10.22146/mot.79125.

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Tempeh is an Indonesian food made of soybean (Glycine max (L.) Merr.) by fermentation using Rhizopus spp mold. Soybean has a high content of protein, fatty acids, vitamins, and isoflavone glycosides. Isoflavone glycosides are poorly absorbed in the human intestine. Fermentation hydrolyzes isoflavone glycosides into isoflavone aglycones which are easily absorbed. Soybean has three main isoflavones, they are genistein, daidzein, and glycitein. They are good antioxidants and have estrogen-like activity. This research studies the antioxidant activity of tempeh ethanolic extract by determining the

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5

Yasir, Mohd, Udai V. Singh Sara, Iti Chauhan, Dheeraj Bisht, Dinesh Puri, and Jayendra Maurya. "Donepezil Base: Physicochemical Characterization, HPLC Method Development, Validation and its Application for the Determination of Shelf Life in Developed Solid Lipid Nanoparticles." Current Nanomedicine 10, no. 1 (2020): 48–62. http://dx.doi.org/10.2174/2468187309666190923111541.

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Background/Objectives: Donepezil (DPL) is available as the hydrochloride salt (DPL-HCL) which is highly water-soluble, prompting leakage of the drug into water phase during solid lipid nanoparticles (SLNs) preparation which leads to reduce the entrapment efficiency as well as drug content. So, the drug was converted into its base form i.e. donepezil base (DPL base). The main objective of the work was to study the physicochemical characterization and identification of DPL base and to compare it with parent DPL-HCL, to develop a High-Performance Liquid Chromatography (HPLC) method for the detect

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6

Nagy, Zs K., K. Nyul, I. Wagner, K. Molnar, and Gy Marosi. "Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl." Express Polymer Letters 4, no. 12 (2010): 763–72. http://dx.doi.org/10.3144/expresspolymlett.2010.92.

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7

Rogers and Friedhoff. "Pharmacokinetic and pharmacodynamic profile of donepezil HCl following single oral doses." British Journal of Clinical Pharmacology 46, S1 (1998): 1–6. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1001.x.

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8

Rogers, Cooper, Sukovaty, Pederson, Lee, and Friedhoff. "Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses." British Journal of Clinical Pharmacology 46, S1 (1998): 7–12. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1007.x.

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9

Tiseo, Perdomo, and Friedhoff. "Concurrent administration of donepezil HCl and digoxin: assessment of pharmacokinetic changes." British Journal of Clinical Pharmacology 46, S1 (1998): 40–44. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1040.x.

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10

SENOL, Sebnem, and Emel AKYOL. "In-vitro evaluation of co-excipients for release of donepezil hydrochloride from Carbopol 974P based tablets." Revue Roumaine de Chimie 67, no. 10-12 (2023): 515–23. http://dx.doi.org/10.33224/rrch.2022.67.10-12.01.

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The prime aims of the present work at formulating and preparing matrix tablets using Carbopol 974P to sustain the release of donepezil HCl. Tablets were prepared by direct compression method and evaluated for the effects of ingredients on the in-vitro release behavior. Gelatin, α-cellulose, sodium alginate, hydroxyapatite, and natural zeolite (clinoptilolite) were used as co-excipients to modulate the formulations. The prepared tablets of the 10 formulations were characterized by using Fourier transform infrared spectroscopy (FT-IR), digital microscope and scanning electron microscopy (SEM) te

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11

Thete, Rohit, Ganesh Shevalkar, and Laxmikant Borse. "Development of Nanostructured Lipid Carriers for Donepezil Hydrochloride Effective Nose to Brain Delivery." Biosciences Biotechnology Research Asia 21, no. 3 (2024): 1145–56. http://dx.doi.org/10.13005/bbra/3293.

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ABSTRACT: This study focuses on the development and evaluation of nanostructured lipid carriers (NLCs) for the efficient intranasal delivery of donepezil hydrochloride. The NLCs were prepared using the microemulsion technique. Each excipient used in the formulation was thoroughly evaluated for stability, assessing factors such as color change, phase separation, precipitation, and texture. Characterization of the NLCs included the construction of a pure calibration curve, differential scanning calorimetry (DSC), infrared spectroscopy (IR), and the IR analysis of physical mixtures. The donepezil

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12

Gencturk, Asli, and A. Sezai Sarac. "Determination of Donepezil HCl Release from Electrospun Fiber by Electrochemical Impedance Spectroscopy." International Journal of Electrochemical Science 11, no. 1 (2016): 111–25. http://dx.doi.org/10.1016/s1452-3981(23)15830-5.

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13

Kiran, Reddy, and Anand Kumar Yegnoor. "Preparation and in vitro evaluation of donepezil hydrochloride orodispersible tablets." GSC Advanced Research and Reviews 15, no. 3 (2023): 128–39. https://doi.org/10.5281/zenodo.8269064.

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<strong>Objective</strong>: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural and synthetic superdisintegrants to increase patient compliance. <strong>Methods</strong>: Direct compression was adapted using crospovidone, croscarmellose sodium as synthetic and mucilage isolated from fruits of Abelmoschus esculentus as natural superdisintegrants at different concentrations along with microcrystalline cellulose and aerosil. The powder mixture were subjected for pre and post compression evaluation including FTIR spectroscopy, micromerit

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14

Barot, Tushar G., and P. K. Patel. "RP-HPLC Method for the Estimation of Donepezil Hydrochloride Dosage Form." E-Journal of Chemistry 6, no. 2 (2009): 594–600. http://dx.doi.org/10.1155/2009/532830.

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A simple and accurate methods to determine donepezil, in tablet dosage form, were developed and validated using liquid chromatography (LC). The LC separation was achieved on a Inertsil C8-3, 25 cm x 4.6-mm, 5 µ in the isocratic mode using buffer : methanol : triethylamine (550:450:5)v/v, adjusted to pH 2.50±0.05 with orthophosphoric acid, as the mobile phase at a flow rate of 1.0 mL/min. The methods were performed at 271 nm. In LC method, quantification was achieved with PDA detection over the concentration range of 20-60 µg/mL with mean recovery of 100.18±0.75%. The method was validated by de

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15

Bulduk, İbrahim, and Beyza Sultan Aydın. "Simple high-performance liquid chromatographic method for determination of Donepezil HCl in pharmaceutical formulations." Journal of Chemical Metrology 14, no. 1 (2020): 69–76. http://dx.doi.org/10.25135/jcm.41.20.04.1622.

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16

Tiseo, Vargas, Perdomo, and Friedhoff. "An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function." British Journal of Clinical Pharmacology 46, S1 (1998): 51–55. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1051.x.

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17

Alsalamah, Abrar. "P4-212: An evidence-based review: Donepezil HCl in the treatment of Alzheimer's disease." Alzheimer's & Dementia 8, no. 4S_Part_19 (2012): P709. http://dx.doi.org/10.1016/j.jalz.2012.05.1917.

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18

Nagy, Christa F., Dinesh Kumar, Edward I. Cullen, et al. "Steady-state pharmacokinetics and safety of donepezil HCl in subjects with moderately impaired renal function." British Journal of Clinical Pharmacology 58, s1 (2004): 18–24. http://dx.doi.org/10.1111/j.1365-2125.2004.01803.x.

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19

Amirthalingam, Muthukumar, Udupa Nayanabhirama, and Srinivas Mutalik. "P1-418: SUSTAINED DELIVERY OF SURFACE MODIFIED DONEPEZIL HCL LOADED PCL NANOPARTICLES FOR ALZHEIMER'S DISEASE." Alzheimer's & Dementia 10 (July 2014): P467. http://dx.doi.org/10.1016/j.jalz.2014.05.661.

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20

Salloway, Stephen, Stephen Correia, and Sharon Richardson. "Key lessons learned from short-term treatment trials of cholinesterase inhibitors for amnestic MCI." International Psychogeriatrics 20, no. 1 (2008): 40–46. http://dx.doi.org/10.1017/s1041610207005650.

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ABSTRACTObjective: This paper reviews the key lessons learned from the first published short-term, placebo-controlled trial of a cholinesterase inhibitor for treatment of mild cognitive impairment (MCI).Methods: The study was a 24-week placebo-controlled trial designed to evaluate the efficacy and safety of donepezil HCl (donepezil) in the treatment of cognitive impairment in subjects with MCI. Primary outcome measures were the NYU Paragraphs Test and the ADCS Clinicians Global-Impression of Change in the intent-to-treat last-observation-carried-forward group.Results: There was no benefit of d

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21

Nagy, Christa F., Dinesh Kumar, Carlos A. Perdomo, Suman Wason, Edward I. Cullen, and Raymond D. Pratt. "Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses." British Journal of Clinical Pharmacology 58, s1 (2004): 25–33. http://dx.doi.org/10.1111/j.1365-2125.2004.01801.x.

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22

Mostafa, Gamal Abdel Hafiz, Mohamed Hefnawy, and Abdulrahman Al-Majed. "Membrane Sensors for the Selective Determination of Donepezil Hydrochloride." Journal of AOAC INTERNATIONAL 93, no. 2 (2010): 549–55. http://dx.doi.org/10.1093/jaoac/93.2.549.

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Abstract The construction and electrochemical response characteristics of polyvinylchloride (PVC) membrane sensors for donepezil HCl (DP) are described. The sensing membranes incorporated ion-association complexes of DP cation and sodium tetraphenyl borate (sensor 1), phosphomolybdic acid (sensor 2), or phosphotungstic acid (sensor 3) as electroactive materials. The sensors displayed a fast, stable, and near-Nernstian response over a relatively wide DP concentration range (1 102 to 1 106 M), with cationic slopes of 53.0, 54.0, and 51.0 mV/ concentration decade over a pH range of 4.0 to 8.0. Th

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23

Tiseo, Perdomo, and Friedhoff. "Concurrent administration of donepezil HCl and cimetidine: assessment of pharmacokinetic changes following single and multiple doses." British Journal of Clinical Pharmacology 46, S1 (1998): 25–29. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1025.x.

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24

Tiseo, Perdomo, and Friedhoff. "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." British Journal of Clinical Pharmacology 46, S1 (1998): 30–34. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1030.x.

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25

Tiseo, Foley, and Friedhoff. "The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin." British Journal of Clinical Pharmacology 46, S1 (1998): 45–50. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1045.x.

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26

Kiran Reddy and Yegnoor Anand Kumar. "Preparation and in vitro evaluation of donepezil hydrochloride orodispersible tablets." GSC Advanced Research and Reviews 15, no. 3 (2023): 128–39. http://dx.doi.org/10.30574/gscarr.2023.15.3.0153.

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Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural and synthetic superdisintegrants to increase patient compliance. Methods: Direct compression was adapted using crospovidone, croscarmellose sodium as synthetic and mucilage isolated from fruits of Abelmoschus esculentus as natural superdisintegrants at different concentrations along with microcrystalline cellulose and aerosil. The powder mixture were subjected for pre and post compression evaluation including FTIR spectroscopy, micromeritic properties, tablet weight varia

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27

Rojanasthien, Noppamas, Siriluk Aunmuang, Nutthiya Hanprasertpong, Sukit Roongapinun, and Supanimit Teekachunhatean. "Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers." ISRN Pharmacology 2012 (November 1, 2012): 1–4. http://dx.doi.org/10.5402/2012/527679.

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The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected over a period of 216 hours. Plasma donepezil concentrations were measured by high performance liquid chromatography with UV detection. Pharmacokinetic parameters were analyzed based on noncompartmental

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28

Ragab, G. H., and E. A. Bahgat. "Development of HPLC method coupled with fluorescence detection for simultaneous determination of donepezil HCl and trazodone HCl in spiked human plasma and tablets dosage forms." Annales Pharmaceutiques Françaises 77, no. 4 (2019): 286–94. http://dx.doi.org/10.1016/j.pharma.2019.02.003.

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29

Tiseo, Foley, and Friedhoff. "An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function." British Journal of Clinical Pharmacology 46, S1 (1998): 56–60. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1056.x.

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30

Knopman, David S. "Management of cognition and function: new results from the clinical trials programme of Aricept® (donepezil HCl)." International Journal of Neuropsychopharmacology 3, no. 7 (2000): 13–20. http://dx.doi.org/10.1017/s1461145700001929.

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31

Tiseo, Foley, and Friedhoff. "Concurrent administration of donepezil HCl and theophylline: assessment of pharmacokinetic changes following multiple-dose administration in healthy volunteers." British Journal of Clinical Pharmacology 46, S1 (1998): 35–39. http://dx.doi.org/10.1046/j.1365-2125.1998.0460s1035.x.

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32

Moaness, Mona, Sara A. M. El-Sayed, Hanan H. Beherei, and Mostafa Mabrouk. "Enhancing the Antifouling Properties of Alumina Nanoporous Membranes by GO/MOF Impregnated Polymer Coatings: In Vitro Studies." Journal of Functional Biomaterials 15, no. 3 (2024): 50. http://dx.doi.org/10.3390/jfb15030050.

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Nanoporous membranes (NPMBs) have been the focus of interest of many scientists in the last decade. However, the fouling phenomenon that takes place during the implantation period blocks pores and causes failure in the local implant. In this study, alumina NPMBs were developed using electrochemical anodization through two steps. Furthermore, graphene oxide (GO), free and impregnated with ZIF-8 MOF, was synthesized and loaded in a mixture of PVDF/PVP polymer matrix at different ratios, and was applied to the produced NPMBs using spin-coater. The NPMBs were characterized before and after coating

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33

Tripathi, Sandeep, Manisha Choudhary, Devesh K. Joshi, Abbas Ali Mahdi, Mahdi Hasan, and Kalyan Mitra. "ISDN2012_0195: Influence of age on aluminum induced neurobehavioral, neurochemical and ultrastructural changes in rat brain: Protective role of donepezil HCl." International Journal of Developmental Neuroscience 30, no. 8 (2012): 677. http://dx.doi.org/10.1016/j.ijdevneu.2012.10.020.

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34

Patel, Yesha K., M. N. Noolvi, Hasumati Raj, and Meghna P. Patel. "Development and validation of stability indicating reverse phase high performance liquid chromatographic method for estimation of Donepezil HCl from bulk drug." Asian Journal of Pharmaceutical Research 5, no. 2 (2015): 96. http://dx.doi.org/10.5958/2231-5691.2015.00014.3.

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35

Reyes, Josephine F., Sheldon H. Preskorn, Ahsan Khan, et al. "Concurrent administration of donepezil HCl and risperidone in patients with schizophrenia: assessment of pharmacokinetic changes and safety following multiple oral doses." British Journal of Clinical Pharmacology 58, s1 (2004): 50–57. http://dx.doi.org/10.1111/j.1365-2125.2004.01817.x.

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36

Patil, Rahul P., Devlya D. Pawara, Chetan S. Gudewar, and Avinash R. Tekade. "Nanostructured cubosomes in an in situ nasal gel system: an alternative approach for the controlled delivery of donepezil HCl to brain." Journal of Liposome Research 29, no. 3 (2019): 264–73. http://dx.doi.org/10.1080/08982104.2018.1552703.

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37

Bashyal, Santosh, Chang Yell Shin, Sang Min Hyun, Sun Woo Jang, and Sangkil Lee. "Preparation, Characterization, and In Vivo Pharmacokinetic Evaluation of Polyvinyl Alcohol and Polyvinyl Pyrrolidone Blended Hydrogels for Transdermal Delivery of Donepezil HCl." Pharmaceutics 12, no. 3 (2020): 270. http://dx.doi.org/10.3390/pharmaceutics12030270.

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Transdermal delivery systems are emerging platforms for the delivery of donepezil hydrochloride (DH) for treating Alzheimer’s disease. The primary aim of this study was to develop polyvinyl alcohol and polyvinyl pyrrolidone blended hydrogels and to evaluate their feasibility for delivering DH via a transdermal route. Physicochemical properties, such as gel fraction (%), swelling ratio (%), weight loss (%), mechanical strength, elongation at break, and Young’s modulus of the prepared hydrogels were evaluated. Furthermore, in vitro skin permeation and in vivo pharmacokinetic studies were perform

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38

Tune, Larry, Paul J. Tiseo, John Ieni, et al. "Donepezil HCl (E2020) Maintains Functional Brain Activity in Patients With Alzheimer Disease: Results of a 24-Week, Double-Blind, Placebo-Controlled Study." American Journal of Geriatric Psychiatry 11, no. 2 (2003): 169–77. http://dx.doi.org/10.1097/00019442-200303000-00007.

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39

Okereke, Chukwuemeka S., Louis Kirby, Dinesh Kumar, Edward I. Cullen, Raymond D. Pratt, and William A. Hahne. "Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses." British Journal of Clinical Pharmacology 58, s1 (2004): 41–49. http://dx.doi.org/10.1111/j.1365-2125.2004.01799.x.

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40

Nabeel, Zaizafoon, Qassim Abdul-Hussein Jaber, and Nabeel Abed Abdul-Rida. "Novel Benzo[<i>f</i>]coumarin Derivatives as Probable Acetylcholinesterase Inhibitors: Synthesis, In Vitro, and In Silico Studies for Evaluation of Their Anti-AChE Activity." Indonesian Journal of Chemistry 22, no. 1 (2021): 35. http://dx.doi.org/10.22146/ijc.65663.

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Novel benzo[f]coumarin derivatives bearing pyrimidine unit were successfully synthesized. The target is to develop novel acetylcholinesterase inhibitors. The benzo[f]coumarin chalcone 4 was prepared via Claisen-Schmidt condensation between 3-acetyl-5,6-benzocoumarin and 4-hydroxybenzaldehyde in the alkaline medium. Then, the cyclocondensation of chalcone 4 with urea, thiourea, and guanidine HCl in the presence of glacial acetic acid led to the formation of various pyrimidines. Structures of the newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra, and elemental anal

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41

Bhupatiraju, Lakshmi, Krupavaram Bethala, Khang Wen Goh, et al. "Influence of Murraya koenigii extract on diabetes induced rat brain aging." Journal of Medicine and Life 16, no. 2 (2023): 307–16. http://dx.doi.org/10.25122/jml-2022-0151.

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Food supplements are used to improve cognitive functions in age-related dementia. This study was designed to determine the Murraya koenigii leaves’ effect on Alloxan-induced cognitive impairment in diabetic rats and the contents of oxidative stress biomarkers, catalase, reduced glutathione, and glutathione reductase in brain tissue homogenates. Wistar rats were divided into seven groups (six rats per group). Group I received saline water (1 ml, p.o.), Diabetes was induced in Groups II–VII with Alloxan (120 mg/kg/p.o). Group III was provided with Donepezil HCl (2.5 mg/kg/p.o.), Group IV, V, VI,

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42

Podsiedlik, Maria, Magdalena Markowicz-Piasecka, and Joanna Sikora. "The Influence of Selected Antipsychotic Drugs on Biochemical Aspects of Alzheimer’s Disease." International Journal of Molecular Sciences 23, no. 9 (2022): 4621. http://dx.doi.org/10.3390/ijms23094621.

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The aim of this study was to assess the potency of selected antipsychotic drugs (haloperidol (HAL), bromperidol (BRMP), benperidol (BNP), penfluridol (PNF), pimozide (PIM), quetiapine (QUET) and promazine (PROM)) on the main pathological hallmarks of Alzheimer’s disease (AD). Binary mixtures of donepezil and antipsychotics produce an anti-BuChE effect, which was greater than either compound alone. The combination of rivastigmine and antipsychotic drugs (apart from PNF) enhanced AChE inhibition. The tested antipsychotics (excluding HAL and PNF) significantly reduce the early stage of Aβ aggrega

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43

Illangasinghe, Jagath, Heethaka Krishantha Sameera de Zoysa, Neelamani Yapa, Thushara Chathuranga Bamunuarachchige, and Viduranga Yashasvi Waisundara. "Assessment of the health benefits of phytochemicals in Cynometra cauliflora based on an in silico study against Alzheimer’s disease." Exploration of Foods and Foodomics 2, no. 1 (2024): 1–29. http://dx.doi.org/10.37349/eff.2024.00023.

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Aim: Cynometra cauliflora (namnam) belongs to the family Fabaceae and is native to eastern Peninsular Malaysia. It grows well with an annual rainfall of 1,500–2,000 mm. Even though a considerable amount of research has been carried out with C. caulifora, there is a dearth of information about biomolecules that may pave the way for drug discoveries and food supplements, which is a gap addressed in this study. Methods: The study presented in this paper has identified several antimicrobial, antioxidant, and anti-inflammatory substances, and an in silico approach was used to understand the behavio

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44

"Donepezil-HCL generisch." MMW - Fortschritte der Medizin 154, no. 4 (2012): 77. http://dx.doi.org/10.1007/s15006-012-0264-3.

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45

Reid, Joel W., and James A. Kaduk. "Crystal structure of donepezil hydrochloride form III, C24H29NO3⋅HCl." Powder Diffraction, July 6, 2021, 1–8. http://dx.doi.org/10.1017/s0885715621000415.

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The crystal structure of donepezil hydrochloride, form III, has been solved with FOX using laboratory powder diffraction data previously submitted to and published in the Powder Diffraction File. Rietveld refinement with GSAS yielded monoclinic lattice parameters of a = 14.3662(9) Å, b = 11.8384(6) Å, c = 13.5572(7) Å, and β = 107.7560(26)° (C24H30ClNO3, Z = 4, space group P21/c). The Rietveld-refined structure was compared to a density functional theory (DFT)-optimized structure, and the structures exhibit excellent agreement. Layers of donepezil molecules parallel to the (101) planes are mai

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46

Rajput, Amarjitsing, and Shital Butani. "Donepezil HCl Liposomes: Development, Characterization, Cytotoxicity, and Pharmacokinetic Study." AAPS PharmSciTech 23, no. 2 (2022). http://dx.doi.org/10.1208/s12249-022-02209-9.

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47

Avvadukkam, Jayashree, Arun Krishna Kodoth, Thency Monnikanda Subramani, et al. "Development of pH‐Responsive Hydrogel Excipient From Karaya Gum for Improved Oral Delivery of Donepezil Hydrochloride in Alzheimer's Disease Treatment." Journal of Applied Polymer Science, December 30, 2024. https://doi.org/10.1002/app.56630.

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ABSTRACTThe present study focused on fabricating an efficient excipient for donepezil HCl from karaya gum as the base material. The karaya gum was grafted and crosslinked with N‐isopropyl acrylamide and N,N′‐methylene(bis)acrylamide, respectively, using microwave. The successful fabrication of the resulting hydrogel was confirmed and characterized by FTIR, FESEM, and TGA analyses. Remarkably, the synthesized gel exhibited distinct swelling behavior in different pH mediums ranging from 1.2 to 13. As expected, the gel exhibited an impressive 96% release of donepezil, a widely used hydrophilic dr

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Surya Anusha, Venna R., Koppala RVS Chaitanya, Rajeswari Aleti, and Kolapalli Venkata Ramana Murthy. "Bio-analytical Method for the Pre-clinical Estimation of Donepezil Hydrochloride in Rabbit Plasma by RP-HPLC." Research Journal of Pharmacy and Technology, November 30, 2023, 5207–12. http://dx.doi.org/10.52711/0974-360x.2023.00844.

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A simple, reliable and sensitive RP-HPLC bioanalytical method with PDA as detector was developed for the estimation of donepezil HCl in the rabbit plasma and validated. The biological samples were extracted and analysed using loratadine as internal standard. The sample analysed with Inertsil ODS 150mm x 4.6mm, 5.0µm particle size column using 70:30 v/v of 0.1% trifluoroacetic acid and acetonitrile mobile phase at flow rate of 1mL/min. All the parameters validated were within the limits proposed in bioanalytical method validation guidelines. The linearity was observed in the range of 5-200ng/mL

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Topal, Gizem Rüya, Berrin Küçüktürkmen, Umut Can Öz, Erva Özkan, Filiz Bakar-Ates, and Asuman Bozkır. "Investigation on formulation parameters of donepezil HCl loaded solid lipid nanoparticles." Brazilian Journal of Pharmaceutical Sciences 59 (2023). http://dx.doi.org/10.1590/s2175-97902023e22330.

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R. Anudeep, Reddy, and Lakshmi Prof.Dr.P.K. "Stable Solid Dispersion Incorporated Sustained Release Oral Gel of 23 mg Donepezil Hcl." International Journal of pharma and Bio Sciences 11, no. 3 (2020). http://dx.doi.org/10.22376/ijpbs/lpr.2020.10.3.p36-42.

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