Academic literature on the topic '(donor) (Smith copy)'

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Journal articles on the topic "(donor) (Smith copy)"

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Landrith, Tyler, Samantha Smith, Jennifer Chan, et al. "Abstract 6162: High resolution detection of HER2 copy number variation in admixed breast cancer cell lines and HER2+ FFPE donor tissue using a digital PCR multigene reference panel." Cancer Research 83, no. 7_Supplement (2023): 6162. http://dx.doi.org/10.1158/1538-7445.am2023-6162.

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Abstract The measurement of HER2 (ERBB2) gene amplification guides both the prognosis and treatment of breast cancer, as amplification correlates with worse outcomes and the recommendation for anti-HER2 treatment. Digital PCR (dPCR) can serve as a useful tool for the direct quantification of copy number variants (CNV) in this gene, without the need for calibration standards as required for qPCR, or labor-intensive histological techniques such as FISH. Furthermore, increasing the number of available partitions in a digital PCR reaction can yield substantial gains in precision, thus offering the
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Leslie, Kimberly K., Lane E. Smith, Jamie Padilla, and Adrian Quintana. "Abstract B015: A novel Cluster 3 Endometrial Cancer PDX model to test hormone therapy regimens." Clinical Cancer Research 30, no. 5_Supplement (2024): B015. http://dx.doi.org/10.1158/1557-3265.endo24-b015.

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Abstract Endometrial cancer is the most commonly diagnosed gynecologic cancer and continues to rise in incidence and mortality rates worldwide. With the evaluation of large datasets including the TCGA, endometrial cancers have been subdivided into four different cluster groups based on molecular characteristics. The most common subtype of endometrial cancer is the Cluster 3 category, demarcated by the expression of estrogen receptors (ER) and progesterone receptors (PR) with the potential to respond to hormonal therapy. However, Cluster 3 tumors frequently lose hormone receptor expression over
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Giaglis, S., D. Kyburz, N. Venhoff, and U. Walker. "AB0026 mtDNA OXIDATIVE DAMAGE IS PROINTERFEROGENIC AND PRONETOTIC, AND RELATES TO ANTIPHOSPHOLIPID ANTIBODY POSITIVITY IN SLE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1192.2–1193. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6194.

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BackgroundMitochondria are essential eucaryotic cell organelles with several bacterial features such as a circular genome with hypomethylated CpG areas, and a double cardiolipin membrane [1]. A fundamental role of mitochondria in systemic lupus erythematosus (SLE) was recently shown; mitochondrial ROS participate in neutrophil extracellular traps (NETs) formation [2], while extrusion of cell-free mitochondria and highly oxidised interferogenic mitochondrial DNA (ox-mtDNA) causes disease in an SLE animal model [3, 4]. Moreover, plasma mtDNA is a sensitive biomarker for SLE diagnosis and the cli
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sprotocols. "A protocol for generation of transgenic mice by manipulating spermatogonial stem cells in vivo." January 11, 2015. https://doi.org/10.5281/zenodo.13876.

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Authors: Lalit Sehgal, Rahul Thorat, Nileema Khapare, Amitabha Mukhopadhaya, Mugdha Sawant & Sorab Dalal ### Abstract This protocol describes a technique for the generation of transgenic mice by in-vivo manipulation of spermatogonial stem cells (SSCs) with a high rate of success. In this study SSCs in pre-pubescent animals were infected in vivo with recombinant lentiviruses expressing EGFP-f and mated with normal females. All male pre-founder mice produced transgenic pups with an overall success rate of over 60%. The transgene was heritable and the pre-founder mice could be used in multipl
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Book chapters on the topic "(donor) (Smith copy)"

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Morash, Christopher. "Theatre and Print, 1550–1800." In The Irish Book in English 1550-1800. Oxford University PressOxford, 2006. http://dx.doi.org/10.1093/oso/9780199247059.003.0018.

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Abstract There is no way of reconstructing precisely the movements of Dublin bookseller William Smith on the afternoon and evening of Thursday, 28 July 1743. He may have spent the afternoon in his shop on the main thoroughfare of Dame Street—a familiar Dublin landmark with its sign of Hercules over the door. It is equally possible, however, that as a leading Irish seller of plays, he went to the theatre to see a production of Joseph Addison ‘s Cato. If so, on that particular afternoon he may have left the shop in the care of his son, also named William Smith, who had just been admitted to the
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